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<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1B0</accession>
    <name>A0A835G1B0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000687">
        <property type="protein sequence ID" value="KAF9405757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1B0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27460" checksum="1B72E085E9A91111" modified="2021-09-29" version="1">MSQVSEIISIHKNVQESLLKRMGDIEAQIQSAGPAKDTVARIAEEFRAFRELVFDMLKMLRAQVIECCRSIDDLEMRSRQKAAIFQGMPELDNEDCSGLILGVINTKLGLDLPVSAIKVCHRLGASNKDHHRPILVKFSSLDDKASVWKAKTRLRGTKISIREFLTKPRQEVFSKARHHFGMRSCWTRDGNIFLKTSDGNKHRVTCLEELSPLLIQYPRAPGASQPEARHGAGVNSSKLKDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1M0</accession>
    <name>A0A835G1M0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000949">
        <property type="protein sequence ID" value="KAF9404543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1M0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="163" mass="19106" checksum="D0D6DC6F76510ECC" modified="2021-09-29" version="1">MSERLKSEVENKQQEIDQLTMRLTSSSKSKERILALEEKVRKVEELRTQLEEQLLDERNKNLENEKQMRQQDLMKNQIAEVLMEAKEKAQQIIERATIEADRTVEVARHETKKAVSEASIELKMINQEAANYHTRILRLQNETSILMEDLLNKSSRLADQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1R0</accession>
    <name>A0A835G1R0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000643">
        <property type="protein sequence ID" value="KAF9406078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1R0"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000004">
        <property type="entry name" value="Trafficking protein particle complex 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16801" checksum="77EA2C23982EF3BD" modified="2021-09-29" version="1">MTIYNLYIFDRYGTLLYYGEWNRSKQSGMSREEEGKLMYGMLFSIKSFVAKISPLDPKEGFMHYKTSKYTLHCLETPSGLKFVMNTDNQAQGVRELLKKIYGEIYVKYAVRNPMCGIGEPITSELFKNKLDAFIKQSPIQYARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G318</accession>
    <name>A0A835G318_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000637">
        <property type="protein sequence ID" value="KAF9406130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G318"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="11178" checksum="CC95059298CA0F98" modified="2021-09-29" version="1">MGKRQHQKDKMYLTYTEWTTLYGGKRSGTSKEEDTTFKRLPFDHCCLCLQPFDDPYCDMDGNIFELQAVLEFVKKFKINPVTGKVSLVQNFDYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G431</accession>
    <name>A0A835G431_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000865">
        <property type="protein sequence ID" value="KAF9404864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G431"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="55875" checksum="528040E59EFF9F28" modified="2021-09-29" version="1">MRGTQQEQIELSAEGACSAFGSKISMFKIIDTVGDTQPPEIPSVSTEDHTSSSEVFEESQNSKPDNCDDGGSSEDYDDFEAHALYTSVDIAKDLRMWSLKHKIKHVALKDLLGILNKRTILRLPKDPRSLLHTPSGDLHITNIKGGQYWHYGFEVCIRDFFHDVKDDEEIYIKINIDGLPIFNSSKNEFWPIIFTIENLNPKPMIIGIYYGKGKPQDLGEFLSPLVAEFNTILKQGIKIGDYTIGVTLKCFVCDSPARSFIKGVANFNSQHGCHKCSIEGEYSHLSHTNYYPNKIYPKRTNDTFRNKEDEYHHKIDSPLLKLPINMIDAFPVADSLHLIDLGIVKRLLTGWRDGYFKNKMLKWPSKTTEELSSKMQSIKLPKELHRNIRGLDCLSFWKALEYRNFILYYGIVVLKGVLRIDVYEHFLILFCAVTICSTDNYKRFYDAATKLLNHFVHQYCKIYGEHYLTSNVHNLIHLTEDVINLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4A1</accession>
    <name>A0A835G4A1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013046</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000565">
        <property type="protein sequence ID" value="KAF9406651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4A1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF237">
        <property type="entry name" value="PICKPOCKET 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="258" mass="29980" checksum="25EADE1E1743244F" modified="2021-09-29" version="1" fragment="single">VIIDNAYNIPDLDSPVRMVNPSTELLIALSPERTYTTSGIRAFTPDQRQCYYSDEIKLGNFRQYSFHNCMAYKKVSMLKKHCNCIPLSFPKEESYRFCNFDDMDCLDQILNEAEDSNVTKELESKITCYPECEHYDYPLEVALGNLADSTYVNGLLFFDDVELKNRSLLNVFFNDLVSTRYRRDVYLNWQNILAAFGGLLSLMLGFTLISGFDLILFFTVRVAYDFCTTIARKPQTNKIYVNDFNSRKKWMDNTIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4W8</accession>
    <name>A0A835G4W8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional adapter 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TADA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000504">
        <property type="protein sequence ID" value="KAF9407121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4W8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22934">
        <property type="entry name" value="HFD_TADA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34145" checksum="CF7EBB2430EFC661" modified="2021-09-29" version="1">MSSDPLNIARRKLNDVLGEKSTKYFNHMKQWFRMKLTKEEFDAEARKLLSTDQVHYHNEFLLALLNKVEGLAEASISIAQEKASSHNRNSRRHKRSSRTSEKSNFEPVDLLEYLPPNSPPGAGSDGVKYAAQEIFLPDHALVVGRFMLAAWETGLEGADDDAADVIVVAVQHFLKNVITAVLSQRKGYKMRNKHFMYDVGGDVPNMWLRNSAKLYDPQRDGRVSVDEGMTDLLGPRCPPTIDEMEHSAAFEIACSANTEPNDDKLTIDEFYNTLLVHKNVISCHSVYAVNMERIASLLNHPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5E5</accession>
    <name>A0A835G5E5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000669">
        <property type="protein sequence ID" value="KAF9405866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5E5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="904" mass="104650" checksum="87761FE6FDF76D9A" modified="2021-09-29" version="1" fragment="single">MGRLIVRPLRLVLNGGSCTIGFDDNSTGLLLLREFLTKHTQSVDLFLFRCCDGMYLRLGDGERDRESDFFQFCLCISSILLLSFDISATSASVLDVEELEATSDIASVGSAVSMILSACSASFVRSVTSLMVNTVRTAADVYFSQLGKTLCFWSELPIDQHSRDCRFPRIPPVIIQMSSVFLRLSLDRVIYVDCSTRFKMAKPNKINRDELLAKKRAAEKARRDKIKLNPEAHAQYKDKERQRYKKRKEDKKLVQINDLTPRQQRNQRRKWKINSKNFREKQKQKTLLQKKLAESTPPDSDFDDEPSFNLAQSSNTPSNPAQFSLAASPSVVQNRVLTRRQLPNITQSSNPPSNPAQSSLPESPSVIQNRQLIRRQRYDMSKKIKFYKQQLNKIKKQNDMLRKRLIRSNNKLKKQYTNSPRTKADNLISDPNKKEEVKKALVFAEVMKKEKKVFKENIEPACKTLKNYKMLTKIIQPKLARKINLSRKLNETKYKVQEDIKLFFESDDNTRMAAGKKECITRKKEKKQKRYLQDTLKNLHKKFLETHEYIVSYSLFCQNKPSWVVTPTDKDMETCMCKLHENMTHRYNQTVIFATLVGCELTNFTILPHQHHKHHPQEHLFWEWDTAITAGIQSFTAEYIEDMFAVLKSDGANLDFANIAEMPDHIIYYWIGFSKEQFMSILSEVPQLTVLKRENVGLAAYLIKLRTGDSDERLSSLLCILRRTLEDLMTKEYFNVASHHLMTDFLCASALINKFHCLITDREDASEILNIIQQNMHLNNSLVDIVSENNLNRRRAQFQSIDANNNNLEDFPRLSVSEMSLICLGSYQIKQAKSYYGEHVRANGCYIIDVCREVDDSLPSGFINDNNMWLLRGRIQSRHVGRKIYFVYILINNNLAGREAISQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5F5</accession>
    <name>A0A835G5F5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000666">
        <property type="protein sequence ID" value="KAF9405889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5F5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13062" checksum="E91C7C8E92FB87CC" modified="2021-09-29" version="1">MSKGWILGHNEEDAAQNRVTLTKGETSDDYILFYQQTCDVPAIPYDFGRCDVVYRGEPNEKIYRFETSSSFLPSSIYTEGLGTNVGKVRLVSQRGEMLYAIVRMYGKIIEDNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5M1</accession>
    <name>A0A835G5M1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000652">
        <property type="protein sequence ID" value="KAF9406016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5M1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF18">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9406016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="757" mass="86692" checksum="E5E43992D44F2D55" modified="2021-09-29" version="1" fragment="single">MYVVVWNIGQLANALKPLLTSSQQVHMSHILKTLDTYCKNKILLTCLLTKSLNNHRYEIVITSISFAVRETFLMKIGLKEEQWGDEQLVEKLLDMMQQTGADFTATFRQLAELEPCEMVSEIKLGEKWSLKRLSSHASWGCWLDQYRERLVKEAGVLPVNSRDCTVTAVDASSSGMFEDERRRRMLSVNPVYVPRNWLLHEAIVDAEQDDYRKVRFLLEVLRNPFEVQPEAEKRGFSAQPPQWAYALKISCSTALRTEQKQSLLGNMVLKSNFKEWKFRSTPNYAALPIDENPEYNVPTAVKDAVFSKVPTEPLAGTLHLVCASDDALTDLLDLHPSVAESEEFINFVAGMEGTSLDIGQTSSEMAELIYSENIKGESWQPQLKGSGETPYSRFGDGRAVLRSSVREMVASEACYHLGIPTTRAAALVVSDDHKVWRDKTYSGRAKQERAAIVMRLADAWYRIGSLEILLKRREPHTLKLLTDFIIKHHFPEIENAEGDKYVNFYKEVAHRNLDMVATWQGLGFTHGVLNTDNISLLGVTIDYGPYGFIDHYYHHYVPNTSDDMGRYAFNKQPEILLWNLGKLAEAMAPILSAEQKQEIDNIEATLEDYVKTKVLKTYLHKLGLDEIKDGDEKFVQDLLEVEPQHLSDKTVLEAKWSLSKLSGVPAWDKWVNSYQDRLKKENVTEEERRRRMVAVNPVYIPRNWILEEAIKDAENNDFEKVRFLLKLFKNPYEVNEEAEKRGYSAQPPSWSYGLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6N0</accession>
    <name>A0A835G6N0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012412</name>
        <name evidence="2" type="ORF">HW555_012928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000544">
        <property type="protein sequence ID" value="KAF9406831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000451">
        <property type="protein sequence ID" value="KAF9407623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6N0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="75" mass="8580" checksum="295454E87D16D16D" modified="2021-09-29" version="1">MASQMQQRLGEVENNTLLCEATILDPRFKKSGFNNPRNFERAASEMKRRIGSDRTQFPQESAVEERVPPQPKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Q8</accession>
    <name>A0A835G6Q8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000397">
        <property type="protein sequence ID" value="KAF9408228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Q8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="315" mass="36363" checksum="D38CA63CC6580961" modified="2021-09-29" version="1">MSSINYTTRTEGQTKINTITWTVPNFIILLENKTNREFRTEKSKDPNGDLSESRFQLKMQFLGRDNDIIEIYYLSPTPVFLKSILTICLKRFEERSIVIKEYHTVQANKWQYLATLFKRDIASYDGRDIFLLSDGSLRLKFQFMVTNDIKVDRSNVPEAQLSNDFENLLNNGLFSDVTMKSAEDVEYKVHKAVLASRSAVLKAHFEHNTTECYTNVVESPLESEVLREVLTFIYSDKAPRVDEIPEKLLAAADYYQLSRLKNLCEEALHKKLTVENAIETLQLADLHSANALKQLTLEFIKDGQAKLITKTDWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6R9</accession>
    <name>A0A835G6R9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_012603</name>
        <name evidence="12" type="ORF">HW555_013469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000654">
        <property type="protein sequence ID" value="KAF9405992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000484">
        <property type="protein sequence ID" value="KAF9407323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6R9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="195"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9405992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9407323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="465" mass="53039" checksum="F6E16288C81D9938" modified="2021-09-29" version="1">MASNEEITGPISQEDVEAADKLKNEANEYFKKQSYNNAIELYTKAIEKNPKNAVFFANRSIANLRLENFGYALSDASKAIELDRSYTKAYYRRAAAYMSLGKYKLALKDFEYVTKVRPNDQDAKMKYTECNKIVKKIAFEKAISFDKKEVNIADSINLDAMTIEDEYVGPALEDGKVTLKFVTDLMEFYKKQNKLHKKYAYKILIDVKAYLQKQPSLVDIKVADDAKFTVCGDIHGQYYDLMNIFKLNGLPSETNPYLFNGDFVDRGSFSVECIFTLFSFKLLYPDHFFMSRGNHETLDMNRMYGFRGEVSSKYTSQMADLFTEVYNWLPLAHCINSRVLVMHGGIMCELLWSDPQPMLGRAPSKRGVGCQFGPDVTNTFLQRNGLDYVIRSHEVKNDGYEIAHDGKCITVFSAPNYCDTVGNLGAFITMNGKDLKPNFTTYEAVPHPDVKPMAYANSFFNMLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G769</accession>
    <name>A0A835G769_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Regulatory protein SIR2 homolog 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">SIR2-like protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_010499</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-decanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-decanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:17932"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:143222"/>
            <dbReference type="ChEBI" id="CHEBI:189688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70632"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-propanoyl-L-lysyl-[protein] + NAD(+) + H2O = 3''-O-propanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:23500"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13758"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138019"/>
            <dbReference type="ChEBI" id="CHEBI:145015"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23501"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47669"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G769"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097372">
        <property type="term" value="F:histone H3K18 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.200:FF:000002">
        <property type="entry name" value="NAD-dependent deacetylase sirtuin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF1">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="17">
        <location>
            <begin position="66"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="509"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9410373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="611" mass="67157" checksum="CD2FEAF9112E79AB" modified="2021-09-29" version="1">MSGDMSDRGGVRSSARLSGESGAAMAAPNAARTAPQGRGRPVSTTAAAAQRRARAAERAAEVEDSPRVLRDKCRRLARALRNAKHLVVYTGAGISTAADIPDYRGPHGVWTRLQRGETVGWVGARPGRPASRTARCRRVEVSRAQPTFTHMALTALWARGTLKFVVSQNCDGLHLRAGLPRRALAELHGDMFAELCAPCRRVYLRAFDTTERTARHAHGTRRLCHACGAELRDSIVHFGERGRAAWPLNWAGALRHAARADVVLCLGSSLKVLRRYPRLWRMQSAPRARPALYIVNLQWTPKDSVAALKINARCDAVMQQVARRLRLRVPRYRAALDPVLAHAEPLADAEAHTTRREPLQAPRDAPDARADHWEPSSPSASDSDEELPLRHLAARLRAEAAEPAPASAAEPAPSSASGPAPAAAAPPPAPPPNGQTDCFHSFQVSLHSGEATILLRAEHAEHGELAERVQPDLELLRARTRDLRRFRMQRAAPAHSRLRRLLEYEPRIQRDADDDKPGDVELRPKLEDETRVKDETRVKDETHVKDEPKEEAGTSEAAGSLAAAIIRRAVLLCRASLYPGLHTIIAPPERPAAECAWCARQFAARRCLWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7E1</accession>
    <name>A0A835G7E1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000251">
        <property type="protein sequence ID" value="KAF9410700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="590" mass="66140" checksum="DED14733A7630270" modified="2021-09-29" version="1">MNFATNRPDRRAVFSPTYSIANYSTETKKEMRHSFGEDLFLVPNNLHLIPDPLMKNLADTIITEEKMAPKSKLNSKIDVKTEEDMHIEPDYNPLSGITNFFAGVMNVITSAMFSKRKQADFVAPPVPQMAAPTMWHAAKVLDENKIVQDENCSGDKSSEFAAPEMTECKKAAAHCQSKLDQVRLLLGTKPVPCNSWARRRPKRVFVEASSVEDSFEDAFSPEDFENIANNSYLEYSSPVCFHDNVFHEVDAPKVKTEFAKAPESPKEPPKTTAVLPQICESTEIVKNVPEIETANEISLLNETKKELVASCEDKLSKLKALMQERKNKSKSPIQVPEPEPVKVTEHIDLPKPRTQSKVKDKRFKNPNRTCGKRTKSKMRKSILDDLQFANEICIDEIASPDNSPSVGSFEKYITTPTEPEKDYFDEVSGRFNPGSVPESEDSFQIVFNDGPKLRRTSDCESEDSFIVFEDSPDSCYTSNDVFGDSSDSEEYDSDSDDMSDSGCGNFSLAASQLSKSVNNLADDSLYVEESDGEDEVDCANVTMCDRADLGEHVEVENEKSSGLLLDERKKKLRRTLPAKKVSFFCISYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G845</accession>
    <name>A0A835G845_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000363">
        <property type="protein sequence ID" value="KAF9408752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G845"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="209" mass="23807" checksum="D0B4798D76272E13" modified="2021-09-29" version="1">MRELGGNMITEDGIKIEWMNHLPAQIRVVLSVNTDSSLDMLAAMADKMMEYSESSNIAAVSSSQPDSVAVNQQVMSAQIQVLSKQLEKLTLEISELRSRGRPHHRRYQRSRSRSKSTAKYQNDSNRYPDLLRPMSLKTPAKHNVVHHIETTGPPLFARARPLPPDKYKAAKEEFERVRKGTFLLDNRATLLSRDCHYFSPSDFVLKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G876</accession>
    <name>A0A835G876_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000359">
        <property type="protein sequence ID" value="KAF9408820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G876"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="111" mass="13377" checksum="25F2971CCD419E8C" modified="2021-09-29" version="1">MMMTRMLRRLRVMKLKVNNYCVSDLRMIIARQETLNDGEVQEKEEHVHVPVTTNERERSRERIQRAAARRRRHSRRGRTMRSTARGRSSQMLSLREIDEANGWTYVPRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8X8</accession>
    <name>A0A835G8X8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000209">
        <property type="protein sequence ID" value="KAF9411893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8X8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="24383" checksum="A0315FF361CDA7D5" modified="2021-09-29" version="1">MNFLSDEFDKLKQDNITYRNEIKQLKKENEMLHYDLSEVKGKFINLDQLSRASNIEIQCVPEYKSENVINIVKQIGRTVSVSINDNDIHYCARIAKLNADSTRPRSILTKFNSPRTRDSFLSAVLTYNKKNVQDKLNTHDLGFGSMQKSPVYVVENLSPDNKNLHAATRKRAKELKYKFVWVRGGRVYARKTETSDTVFIRNLDILHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G918</accession>
    <name>A0A835G918_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000343">
        <property type="protein sequence ID" value="KAF9409057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G918"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="64" mass="7138" checksum="01C12630CD310B40" modified="2021-09-29" version="1" fragment="single">SRRHEDDDAVTVSINGGATIKITLKSFKKPVTLRDLWKTCMTDMKMSVVNTKARSCSVIHGVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I0</accession>
    <name>A0A835G9I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">HW555_010634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000272">
        <property type="protein sequence ID" value="KAF9410240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF38">
        <property type="entry name" value="INNEXIN INX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="415" mass="48100" checksum="FFDE6406DBE635A6" modified="2021-09-29" version="1">MFAATLTNLLGPRFRIVLRKPIIENIAFKLHYKATCTLFLTAVILVCMRDYFGETIKCMADNGVPTPIIEKYCFFMATFTIVRHYNESLLQGGFLPHPGVGPMMESDETLHHTYYQWVPFVLFVQSIAFYMPHYIWKQKEGGRIKALVDGLQYASLALIKEDMKVGNMDLPSEETLSKRINIILRDIRLRLRITRTWSVWLVAMEVTNLVHVMFEIWIINEFLNGNFISLGPKILNMSEWGNIADPLETVFPKVTKCIFHKYGPSGSIQQHDALCVMALNIIHEKIYAVLWFWLLFLFIVSVIAVIWRIMSFFLYRRSPRFNMIMFQRATDAKFDPMNVIHIINGCQFADWLFLYYLAKNMQGAVFKELFNRLANELAKKEVAGYEDPIEKKGAAPELSNIVNYDDETLPLQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I9</accession>
    <name>A0A835G9I9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000258">
        <property type="protein sequence ID" value="KAF9410535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF58">
        <property type="entry name" value="AGAP000074-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="673" mass="76183" checksum="7E851FE62FDB8637" modified="2021-09-29" version="1" fragment="single">ESTSEKQSPRIFSLSKGEESGSATPIGDRASPMLYNGNLKNGDAKSLNSYRLYMPQSDMRGSATPRKRSVVTMDAQSIRSVETHAPPPTSPEDNKRLTTKYLTLIISCMYAVLLVTLGLVVYLGDSFVNESISDIYSIILCSIGFVYIFYLIFDITRYKSIAAKNHKIKSMHEEKIMEFFRKQEEQMGSVTPGDRTPESISTYRPPGMPPPVLIPHKHEYCFSQGRHSGSFYLKMGAAVLLLAVQIGQLVDENLDNDECVNILQVVLDVLFPVYCFVQLYFVFKYSNVIILKNQGVAHFAFMHLIGSSLCFWISAIVRETILGLTIYASSRERNGDYYSDYNASTLVPEYEKPLDERFLDVSNLYNPNCNNSAAINSIYEKISPYLYPFSVEFNILIVAIYYIIWSNIGNCDNEDGNSDANSTSDDTYHLCKIPTANEDNDFTSNIVIYADCHASNRGMFLGLIVMVIITGMLIIGFVFSSVGEEFMELGYLLNSCTKLGLHVLLLFAVVIAFNQLRQLDINEHPISLLDDVLLFICLPAFFMETVFSLVATISYANIVKSIDFIIMVIQVLIQTPLIMDGLRRCSNTKKLRRKKPGREILMFLLIANVAMWIFNTFSYKSPDSLDERYEFYGKVIWTILGHISLPLIMFYRFHSSVCFADIWDSAYKPGSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9J8</accession>
    <name>A0A835G9J8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_010399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000258">
        <property type="protein sequence ID" value="KAF9410550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9J8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="14">
        <location>
            <begin position="38"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9410550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="723" mass="81814" checksum="FB84FCAAE5549FF9" modified="2021-09-29" version="1">MSKRSQPSWSPPVKPGKKPVLKLYNSLTRQKEEFVCDNGNRINWYSCGPTVYDASHMGHARSYISFDILRRVMANYFGYDILYVMNITDIDDKIIKRARQHHLFEKYVEEKKSLNCIIDDATSVVNYYETIVKEATDPDKKNAMQKTLDCIASAVKSLKVAVEGNDDATITNAKCELLQSAKGPISEWLDNQYGATVTDNAIFTALPRYWENEFHKDMKALNVLPPDVLTRVSEYVPQIIKFIEKIIDNGLAYESNGSVYFSVSDFDKNDKHYYARLVPEAYGDTKSLQEGEGDLTDDTSEKRSPNDFALWKRSKAGEPSWSSPWGAGRPGWHIECSAMASDVFGSKLDIHTGGVDLKFPHHDNELAQSEAHFDQPGWVNYFLHTGHLTIAGCKMSKSLKNFVTISEALRRHTARQLRIGFLMHGWKETLDYSDNTMDMAIQMEKLFNEFFLTVKDALRSGYDEGSGGVWDEQEQQLSNKLTAVKDQVHAALCDNIDTRSALDALRELVGAAHVYLRQTTPRNSPLLAAAARYVTDILHVFGAVEGPRGGIGFPVSDGNNVCLEDTVMPYLEALSKFRSSVRDAARSAQAPAVLALCDKLRDHDLPELGVRLEDKPDRTVVKLVSKEEIMKEREEKARLEAEKQRKKQELLEAQRAKEELKKIPPGELFKRETDKYSKFDDKGLPTHDHEGKELSKGLVKKLQKLQQAQEKKYNEYLASINTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W7</accession>
    <name>A0A835G9W7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000313">
        <property type="protein sequence ID" value="KAF9409509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="35354" checksum="3C94F1BBC24F9263" modified="2021-09-29" version="1">MPRAPKEGYPPERTPLRNPLCDFMPSPPAVQGPVWPADGGENVLPYRMIHVSAQIGAPYRAMLFRCRRTVLGSRGGWRCRDPWKNTASVLCSATVSPRRETLLPPLNHPPKPSCSQLFHQKDSAVPQSIGNYECDICKIRTESLDKLVSHLKCHTNRYKCRECGLVRACRTTILDHFSAYHSEGVFHMCPYCSKTFKRQACLRKHVSGHRSRARVHCVHCQRSYKDADGLRAHMLLKHAKEISAREVSKKYVCQECGTAFKTPSHLKTHGLKHTDSRNYYCVECDKSFKSAATLKTHLQTTAKHTKYIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Y8</accession>
    <name>A0A835G9Y8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Y8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7964" checksum="4D56DD09352C25CC" modified="2021-09-29" version="1">MLCVQHVDLVADTVAAGRGRHHPVPLPVCVVPPLPPPPCYYSRHSNLLRYKYSGRVSSDDSHLRTMWLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAF6</accession>
    <name>A0A835GAF6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000270">
        <property type="protein sequence ID" value="KAF9410279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="243" mass="27905" checksum="6366C3AF2C4B34E4" modified="2021-09-29" version="1">MSLRAIKLVTFDVTNTLLQFKVPAWQYYAKVAKDYGFNGPDDQIKTRFKKSFNHMWEKHPNFGKKGIEWEEWWTQVVSMTLKDHLPSGTDVATVAHELIEEFRTDRCWQSASGGEKLMHHFKNLGIQIGVISNFDPRLNDILNNVSLKKYFDFIVTSYEIGYSKPDERIFKSAIGKCKVPVTPPEALHIGDDIVKDYQGARAAGWHAVLINPDLDKGSEPLQHHVFKSLEELSNVIMEKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAK8</accession>
    <name>A0A835GAK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAK8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="225" mass="26416" checksum="6477F6290CF38DE6" modified="2021-09-29" version="1">MGKGFNNYMCKKFFHPASRDNLKRVWMAEQKTEAYKKKQEELRVQYEKEQELHENKALLSKDSKDKLSLNFMYEPPPGVKKEREREDNEPEYKFEWQRKYNAPRESYCKGDNEIRDQPFGILVRNVRCIKCHKWGHINTDKECSMYSLSMSEARALQASTSAPEEEEEKPDVPTLMQQMRDTGLVMKPGALPLSATRIEDNDSTSITELDLISQLTKKQKKKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB79</accession>
    <name>A0A835GB79_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="31">PARP</shortName>
            <ecNumber evidence="31">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="38" type="ORF">HW555_009441</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="38">BAW_Kor-Di-RS1</strain>
            <tissue evidence="38">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:58225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-histidyl-[protein] + NAD(+) = N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72071"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:18085"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:191398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:72072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-seryl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-seryl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58232"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15091"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142556"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:58233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-tyrosyl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-tyrosyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:15092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142557"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:58237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="38">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="31"/>
    <dbReference type="EMBL" id="JACKWZ010000209">
        <property type="protein sequence ID" value="KAF9411906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08001">
        <property type="entry name" value="WGR_PARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038650">
        <property type="entry name" value="PADR1_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049296">
        <property type="entry name" value="PARP1-like_PADR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012982">
        <property type="entry name" value="PARP1-like_PADR1_Zn_ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF112">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21728">
        <property type="entry name" value="PADR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08063">
        <property type="entry name" value="Zn_ribbon_PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01335">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52007">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 31" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 31" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="21" id="KW-0804">Transcription</keyword>
    <keyword evidence="18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10 31" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="15 30" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="32">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="32">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="33">
        <location>
            <begin position="391"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="37">
        <location>
            <begin position="542"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="36">
        <location>
            <begin position="662"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="35">
        <location>
            <begin position="739"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="34">
        <location>
            <begin position="877"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00024159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="KAF9411906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1360" mass="154132" checksum="7403D833145213E0" modified="2021-09-29" version="1">MKLGLKESLLFLKRRDSVKDGITHPTNIMTDRDLSYIVEYAKSGRSGCKACNATIDQNAVRIAVLVQSSHFDGKEKRWHHENCFFKSNQPASTAEIGNFCNLKIDDQMRIKSKIEKSTGMVVPVVKPSNPQKRPTDPEAVSNAQALKKYNIQCCKSNKISCTHCGIKICKDEIRISKKVKKNNQKKPDLLSYHVNCFVKLRNELHFYAGGDSIPGFKTLKKKHKEMVLAEIKPLNDDEIPIKKIKKETSEEDHKKIVQQNELFHKYRKALSELSKQDMEKLLEANSQKLPHRSGPNERLDRLAECMAFGKLEPCEECKQGQLVLLTNKYKCTGNLTEWTKCSYVTQNPKRSPMVIPDEFAKTPIFENFTPCTDVRLFETALEPHATTATPVEIPPLKDLQFFFYGDFDNKEQIHKRILKLGGVVITKLVDTTAAVISTKANVEKMLYKMQEIRSKDIQVIEETFFDVIEKAGSCTVAQSLELIKENNIADWGSDPAARVSTKVSGENSSIMKILVRIKLKHPLSCPPGGSSVDPACKLNLSKVHVYVDSNNTKYTVVLSLTDIVAQKNSYYKLQVLEADDKQKYWLFTSWGRIGTPCGDFRTVPYESQEAAVEKFEYLFQEKTQNEWSKRGQFKKFPGKYYPLEMDHVTDFASNETLVVSDKCALDKTIQNLIITLFDVTTMNKTLTEFELDTGKMPLGKISKNQIIAGYNILTEVQALIDSGSTDKNKFIDATNRFFTLIPHNFGANNPPLLDNAEIIRSKTALLDNLLEIELAYSLFKKLIREGEDDRYTPFKKLHNRRLLWHGSRTTNFVGILSQGLRIAPPEAPVTGYMFGKGVYFADMVTKSANYCRKSFFDTVGFLLLCEVALGNIMSGDRKSSKAWQFFTDLNNNKAKCNFCQKEFSYKGGGAYNLIRHTKSKHPHVFVAIRECPLLESTASATEIQHPSTTTVSIARELNTLTASTSTASAACMPEKPDSLPATTAIFKAPATNTKLTQYFCKPLSAKKTDQLNKMLVKVFTKNYLAFHLVESPEFKDFMKELNPAYQLPSRKTLSNALLTNVILISNALKKNCVKFLSSSHPDCVLRMAQVLLNEISTRFSGIEDNNIFAESTILDPRFKKYGFENKYACDRACSNLKAMAGRIEVNSGQTGFEEPASSSPPPHKRKRSIWDEFDEQVEIIMKNTNPTAGGIIEVDKYLEEPLLPRSQDPAKWWFSKKDAYPRLYKLFLRRLCIVATSVPSERTFSKAGQVLTERRNRLSGNKVKLTAVFDYRHKVIRADRSPLPQGMHSRFGEGATMPNPCHNRVLDDGTIVPLGKPIRIKPDARDTLYYNEFIVYNEAQIKVHYLLQVKFNYLEKPITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBJ5</accession>
    <name>A0A835GBJ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBJ5"/>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="13867" checksum="27A6FFEAC0581281" modified="2021-09-29" version="1">MTLFDLDEFLDMPPVKRGRRGVSGDEDDEEYRRKRERNNEAVKKSRVKSKQQTQDTFSRVKRLKEENQQLEDTTKRLTKELELLKELFIATAANKSNPKFEGMDLEKLLEDTPEVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBW5</accession>
    <name>A0A835GBW5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBW5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="103" mass="11484" checksum="179D3652EAFBB759" modified="2021-09-29" version="1">MERTFLLLANNIPSVNCHIPSHVSTPSSKNDQFCLLSESCVHDTIRVCGVMGDKKRTFLDWCDLLEFACDTNQSKQDGRTGRQSRHLRTTPSDLATDGRAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC96</accession>
    <name>A0A835GC96_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000215">
        <property type="protein sequence ID" value="KAF9411721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="225"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="516" mass="56779" checksum="81E0FB8184FB2ECC" modified="2021-09-29" version="1">MISMEVGVQVVGIVLRLLNFFLAPLFWFRARDSRRLPPVTNPVLLKSAAELADSVRKGEISSEELVTVFINRVKEVNPYLNAVVEERYRAAIEDAKAIDRWIVETKKSGSFEELVKEKPLLGVPFTVKESCSLAGLSNSVGCLENAGRRATADGGVVSLVKKAGAIPLLVSNTPELCLGWETTNLLRGTTNNPYCLNRTPGGVAGQRCVSAERGVRHRGLYPPAAAFCGVFGHKPTPGVISIEGHIPTLSDEQFPKFLTVGPMTRRADDLPLLMQVMAGPDNTLNLDKPVDLREVKVHYMLEATDAMALLRVDRCILDAIRNAVRYLEKECGSTVCQEKFKDLEDSVEISVSVFFGMKDIPNLMQDPANPKRDKSLVVELIKYMFGGGSRSLQGLSFSLINRSHLFIPEARSGYYHARANKLREHMEKTLGDNGVLIYPVFIGQAHHHNQVFLKASGVMYTMVFNILGMPATTVPMGLYKGLPVGIQVIAAPHQDRLCLAVAKQLEIGFGGWKPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCJ4</accession>
    <name>A0A835GCJ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000194">
        <property type="protein sequence ID" value="KAF9412289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCJ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="74475" checksum="0099E7E36280CBA3" modified="2021-09-29" version="1">MLLNLALKRLDPAIIHLFEMHMRDVEIPTYTDFVEFIKSQVKILDSTVHTFVACENNQTCLYCNNKDHWKLYTCPKFQAISASSRLDFIKNKRGCVNCLSATHTASQCKSIHTCRTCNKKHHSLLHLEQSSQPRSTSADAVSSSAHSQQVALCACSRVGINIPRTTVLLSTAQVYVDNKYNQYVSVRCLIDNASQNNIITSACCKKLQLNIIPLSNSVIKGVGTSSRPIIGYVEITVTAKNKANSFKITALVIDCITDKLPSHVVDTSAVQHLFELPLADPLWHVPGEVELLLGAKLFPYLLLHNKILSPTAPSAVETVFGYILMGEIPSSLSNKNDIDLNTASYFSTALNIDDSHCFLSLDESLHKFWNIEEIPSKSFMSPADRECEQLYVSTVSRDSSGRYCAALPFCKNPELLGNSYAVAYRRLINLEKTKLRDPALRASYNEIIQEVAFGLKSSPFLAMRTVRQLSEDEKHRFPRASIVASQELYMDDLANSTPTVEEAKTLSAELIALFKAGGFDLTKWAILSQSYSFFLSNPTTIPQRVLDRSANEKRFRRSDTPRRQRYGREDEEVMGLKFCNEAIMSLAQIWPLHCNHDREPNSPLQNAVKSSFILSEHAILYRPTVLSKIFMEKVPPTISAKRATSNESSKSNLPDLKFQKQALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCZ7</accession>
    <name>A0A835GCZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Suppressor of hairless protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_008501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990433">
        <property type="term" value="C:CSL-Notch-Mastermind transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01176">
        <property type="entry name" value="IPT_RBP-Jkappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000001">
        <property type="entry name" value="Recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000003">
        <property type="entry name" value="recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000074">
        <property type="entry name" value="Recombining binding protein suppressor of hairless, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="12">
        <location>
            <begin position="48"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="13">
        <location>
            <begin position="181"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54652" checksum="5586E7EA7A55CDA9" modified="2021-09-29" version="1" fragment="single">ASPPAQHAALFPRYGGAAGPGAGAYRPEERRLTREAMERYLRDRSDMVVVILHAKVAQKSYGNEKRFFCPPPCIYLFGDGWRLRRERMLREGETEQAAQLCAFIGIGNSDQDMQQLDLNNGKQYCAAKTLYISDSDKRKHFMLSVKMFYGNGHDIGIFNSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVENGNFHASSTQWGAFTIHLLDDNESESEEFAVRDGYVHYGSTVKLVCSVTGMALPRLIIRKVDKQMALLEADDPVSQLHKCAFYMKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYEGMGPVRSPVTPVPLVHSLNLNGGGDVAMLELAGDNFTPSLQVWFGDVEAETMYRCAESMLCVVPDISQFRGQWLWVRQPTQVPVSLVRNDGIIYATGLTFTYTPEPGPRPVCAPVDDVMRPDTAPGWHHDHAAHRLPDNTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD10</accession>
    <name>A0A835GD10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25909" checksum="B8F06968DBC1CC13" modified="2021-09-29" version="1" fragment="single">YAQLEGLVEFLEQNPGIAKGLLRTTQAKLEIKRKWATLATSLNSLGGANKDGQGWAKYWAEKKCTLKKQCAQMSSSMRLTGGGTASNLPTLSALDQRLVAVMGGHEFGNRDSRLAVDPFPELTIPTSPIIEMPVIETPMIKDTSPVPGTSHDDTSQPICLIPPATPTPTPVHSHHTTTVTIPQPRRRRSLIPRQNQNADMEQFARIEERRVEAEIAEHMGTIGCALLEISRKMPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDG0</accession>
    <name>A0A835GDG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06707">
        <property type="entry name" value="PDZ_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000097">
        <property type="entry name" value="PDZ domain-containing protein GIPC1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF1">
        <property type="entry name" value="GH21964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="26827" checksum="F89B4603922137AE" modified="2021-09-29" version="1">MWILFCTLNTHKVDMKKLLGGQIGLEDFIFAHRKGRPKEIEIVKTEDALGLTITDNGAGYAFIKRIKEGSIVARIPHIEVGDHIEKLDGENMVGKRHYEVAKILKDIPKGTTFTIRLVEPLKSGFASIGPKTSGAKSGRKQNYGSGKETLRFKANGQATIENDHDERSKAGIEKINSLLESFMGINDSELASQMWDLAEGKTNSMQLAEAIDNSDLQEFGFTDEFIIELWGVITDARSGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDU8</accession>
    <name>A0A835GDU8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="26631" checksum="60906474325D1660" modified="2021-09-29" version="1">MMMGALNSNVKSDLHFIQTKSGHLQLIYEPYIFVTDSFIGMCTNSRLTLEFFGCGLILNGTGTGEAQVCYTVTRRGAPSLLVDGFGFVARKRRGPRVYWTCRSRAQGCPARALTTDGRLVARAGSHTHERHAPAIDEHARIEIEFVISNRGRRHMRLDGFSFYAEKVFPEKNKVRWRCTRRTCRAYAHTLHDRIFALSNVHSHEPPTGVQGDRERNSNRGFTNANFAAQAKAVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDZ6</accession>
    <name>A0A835GDZ6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_004533</name>
        <name evidence="2" type="ORF">HW555_007996</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000705">
        <property type="protein sequence ID" value="KAH9632518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDZ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9632518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17900" checksum="5E0A87F3CCF7CABE" modified="2021-09-29" version="1">MTSERAIPHLRDIFGLNQQYDGKTFDDNDDKTKKSRKKKEDYRTYPNGDVKTLERHLSMKKTIRKKIMRDLQQAFVEDPNEFKVENTSPEKLKAELSAEAVKIEKNVRKNDPTFLDILRGETRGEEAREEQPPAEKTSFWRRLTMKNKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF15</accession>
    <name>A0A835GF15_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000148">
        <property type="protein sequence ID" value="KAF9413892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF15"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12649">
        <property type="entry name" value="RRM1_SXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="149"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="407" mass="45045" checksum="9D2010C70E41DF9D" modified="2021-09-29" version="1">MCERYPGYLFGGTPVSSWDRSFNSLENQIQQQYRGRAGAGARCWGSMSEGGGVSAAGGDSCKTNLIVNYLPQTMTEKDLYAMFMTIGPIESCRVMKDFKTGYSYGFGFVNFTREEDAARAIDTFNGYQLRNKRLKVSYARPSGDDIKDTNLYVTNLPRAITEEQLETIFGKYGRIVQKHILRDKSNGTPRGVAFVRFDKREEAQEAIAALNNVIPEGGTEPLSVKIVDTDYSKSLHHRPAAMLCTDAACRVPTADCGSTVTQWCEPGLTSLGAHGRSSVSLTTLERQPCVSSRVAEEHGKQKAAYYAGWAAGFHHNRGDYAWTCGNCMMPDPWERFSSPPLPGSHPTTPRNGCRPGVCVNSRVYPPNYVGKGASRASRGRNLPWAPNYGAEERYKGQRCRNAPTPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGU1</accession>
    <name>A0A835GGU1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_008604</name>
        <name evidence="8" type="ORF">HW555_005236</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000066">
        <property type="protein sequence ID" value="KAF9417729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000862">
        <property type="protein sequence ID" value="KAH9629560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="7">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9629560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="20581" checksum="53EE9E1A71C8AA13" modified="2021-09-29" version="1">MSLLPYFFDEFGFQRPRRLLDQHFGLALTPDDILSVAAGPLMTREYYRPWRHLAAAVKDLGSSIKADSDKFQINLDVQHFAPEEISVKTADGYIVVEAKHEEKKDDHGFISRQFVRRYALPEGTTPETVESRLSSDGVLTITAPRKVPDAIKGERKVPIAQTGPVRKEIKDQSNGTEEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHA7</accession>
    <name>A0A835GHA7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">HW555_007347</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="36">BAW_Kor-Di-RS1</strain>
            <tissue evidence="36">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHA7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KAF9414878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="37051" checksum="C7118FB38A761333" modified="2021-09-29" version="1">MVKARKYVVVNEFKGWPKREDFQIEEYELPPLKDGEILVKTQWLSVDPYMRIYSSPQKYDQFGFNIGVVTETKAADYPVGTKVVSHKGWCDYVILDTNKFYDDFHPTGKVYKLPEMKGLPDSLAAGAVGMPGATAYFGFLEHCRPKPGDTVVVTGAAGAVGSLVGQIAKIKGCKVIGFAGSDEKVKWLESIGFDKAINYKTADNAAALREAAPQGVDCYYDNVGGELSSTIIYQMNHYGRVVVIGSISSYNEDPQNLPKVTLLQPAILLRRLSVRGYVVWESLEKFPEAFDQITKWIQSGKIVAKEHVTEGFENLYDALVGVLKGENIGKAVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHF9</accession>
    <name>A0A835GHF9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000066">
        <property type="protein sequence ID" value="KAF9417732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="326" mass="37303" checksum="AB0EF0DEB5553949" modified="2021-09-29" version="1">MVNYCCVYGCGRNSKTSKHLYYYGLPKERNRLLQWLEAIGRTDLLERDHKKLTHRVCSRHFTPSNIKNKHLCADAVPTLCLSNCKNEGSIEAESQTEHNNIVCNSCTKAIHGFRYKCITCPDYDLCSKCEMLEAHDQHYLLRIPKPVNFAVADDLIKKWRQFLKKENIKSGIKTDSDCSSDDDVPITKYVKNYDSGIELTEEEKSKIRNEVTRVLNIKQSSTEDSSKGKQKALKRKLPQKKRRDKEFKELVEICVGAEEMTSVTAVPEVFFADVNDIRVNQTLDVKEEITNTLTPLATETDSHIDNSIKLNDELSEFLIGVKYTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJC2</accession>
    <name>A0A835GJC2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJC2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF79">
        <property type="entry name" value="ASPARAGINE-RICH ZINC FINGER PROTEIN AZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="490" mass="57988" checksum="DAA0130E118DDD2F" modified="2021-09-29" version="1">MPLAKLVLKMEDKMHICSACLSTGRHLISLHNISDILEEISLLELKNSLHKVCWECWCIIKKFYKFKKKVRIAQNTLLQSKKKTKFKSLSTLTVTTNLNYNFEYIYNDDFLINNLQEQSSIKKEVHHQTDRNSHKTLGIDENIQNTKKSIENTHTDEFETKDNIASIKHFYESHLEPIVANDIDYKEEVLIENIYVETLDLKPDTKTLRESKRNHHNFKKIPFKCEMCVLGFTREENYNLHMQKKHAESIGAYQCDVCKIRFSTKLAANKHKRKHYVCYRCRCCRYKAHELWSALNHCRTKHLSDEPDKIHCSQCEVIVKTPQELEDHIQDVHSLHCNECGVKFKASSTLRRHMARIHSVIRDFICDICSKTFKTKTRLESHMVKHNASIAKKLAYCHTCDVQYKNIYVYRNHLKSSANHTERAYSCPECSKKFASKVYWTNHYNFYHLQKSQYKCDICNKRSYMCEDCGHTFKQRAALYTHTRLLHRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJH9</accession>
    <name>A0A835GJH9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJH9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032879241" evidence="1">
        <location>
            <begin position="26"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="301" mass="34529" checksum="A9BC159E67C271ED" modified="2021-09-29" version="1">MCNMRLSSLRLLSVLLGYLVAQAKAYPMQGWPMYPQTSREYPDDEYYYAPKVQYFYDAPAISVPEMHAQVPYPYFYDPYGHFIANEAPKRQEERLAALPIGQETWFESDTTPRWQSNDVDDVSAAFLDNLILTQMAQDAQRRRENARAAFPPVDYDEHDAEDEDVRELKALAGKPLYHVPKTVPRIDEDDYASDDGFINWNGNKRSVTTAAPQVTTEAAKAGDKEFVRPQPAANPFSRGHQNSQNKRSNAFYDTIVQYFADKNTNKKLQDTAKERRIEKRFIADDSDLVGELRGLKHRIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJX5</accession>
    <name>A0A835GJX5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="53188" checksum="67825D88F7515044" modified="2021-09-29" version="1">MLCKVPECESSPPEFEAGSWGTFALPDAGARCNRLVPLGEECVPSSFSANETKKCQSWVYENQNTIVPEFDLACQEWLRTLVGTIHVAGVFGSLPVTAYISDAYGRRTALVITAVSPAVVGVIRAFSNSYIMYICFEFLEAFVGAGVYSTAFILALEMVGLDKRVLGGNLISSTFALGQVVTAGVAWLVPYWRTYTLVLYAPSVLFISYYWLIEESVRWLLSKGRNKEAARIIFKAAKMNGKKLSPETIRTLTEEPEQKKSTQTDEPEEPVDKRSILLQVVRSRTLMFRLIVCSFWWITLTFVYYGLSINSVSLVGNSYVNYILTSLVEIPGYCLSVLTLDRFGRKSSTMTAFIICGVSLIAMPFVPESIPWLQTTLNLLGKLCISMAFSSIYIYTGELFPTQARHRLLGTCSMAGRIGALVAPQTPLLMAYVESLPYLIFGIMAGTSGLLMMLTPETLKANLPDTVAQAENMDKKKTTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKJ9</accession>
    <name>A0A835GKJ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ecdysone-inducible protein E75</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear receptor subfamily 1 group D member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004752</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKJ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018990">
        <property type="term" value="P:ecdysis, chitin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007553">
        <property type="term" value="P:regulation of ecdysteroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035075">
        <property type="term" value="P:response to ecdysone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000029">
        <property type="entry name" value="Ecdysone-induced protein 75B, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000013">
        <property type="entry name" value="Nuclear receptor subfamily 1 group D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="253"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="363"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="666"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="761"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="915" mass="100147" checksum="272EEFD01DA6D5F2" modified="2021-09-29" version="1" fragment="single">GWAGTVAFVPVSFGRRGKADRLAPRDKVPEVYGQREAGKEGDAAAGQSVTRRPTPRSPSISSISCSSSLAFHHQKYFRSVTQPAAATSHSNARLVSLSVPLSRDLGRGEPQGSGLRTRAGARAAGSGVVSPPIARRARETRTASSRSARGTRSVRRSSSSETHAARAAAISRDERPSSLDVPAARHGPCTPVLYSVLQRAGRFHVSSQRAPCVMSPDSSYGRYDAPTPADHNMMSPAHKEREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSSTSRANEQAAAAELDDAPRLLARVVRAHLDTCEFTRERVASMRARARDCPTYSQPTLSEKEFSQRFAHVIRGVIDFAGLIPGFQLLTQDDKFTLLKSGLFDALFVRLICMFDAPLNSIICLNGQVMKRDSIQSGANARFLVDSTFKFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNVELVERMHARLKACLQTVVAQNRPDRPGFLRELMDTLPDLRTLSTLHTEKLVVFRTEHKELLRQQMWTDEEGVMSWGDSGADESARSPIGSVSSSESGEAIGDCGTPLLAATLAGRRRLDSRGSVDEEALGVAHLAHNGLTVTPVRPPPRYRKLDSPTDSGIESGNEKHERIVGPGSGCSSPRSSLEEHSDDRRPPPSADDMPVLKRVLEAPPLYHTTSLMDEAYKPHKKFRAMRRDTGEAEARVVRPAPSAQPPQHPHPASPAHPAHSPRPLRASLSSTHSVLAKSLMEGPRMTPEQLKRTDIIQQYMRRGEAAAEGCPMRTGGLLTCYRGASPAPQPVMALQVDVSDADAPLNLSKKSPSPPRSFMPQMLEAKRECVAGAGRGEDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKX2</accession>
    <name>A0A835GKX2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000066">
        <property type="protein sequence ID" value="KAF9417740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKX2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033029300" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="68" mass="7873" checksum="86AFD75E995C427D" modified="2021-09-29" version="1">MNHTIALSLLSLIPILSFQPRPATNTSPPRIPHRRRSRRCVAWPSVLKVIRRGPHVDLPKKYQNLKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL31</accession>
    <name>A0A835GL31_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL31"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050435">
        <property type="term" value="P:amyloid-beta metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032834312" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9420004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="472" mass="52100" checksum="7D7C895F6CE98849" modified="2021-09-29" version="1">MSVTFIIFQISVVSLSYSFGEEINLYGDAGEAYAIEVNIGHPHQKFKLLVDTGSTTLALASYAREDSNIYFHADNSSSLFNSGTTIEAAYTQGTWTGLLASDFIQFPSLSIPEVRSDFALITKSHEFFTKASVWQGLLGLAYNPVGAWGKSGAVESWLDALDRHLNKPMSFQLKLCGPISTSNTTHYGYFKVIDNQTPQSNHNKTFRTPVLRKRWYEVGVIGVRVLSSLTSEAKNKTVGEIREPDKDMCVKLNTVKSIVDSGTTQIKLPEKLFREVVDELKNEFRKSQAACWLEPQVWTLPWLAIDLLSAEADNQYFTLEIPPQNYMLVVGVHNSSDTSGTVSTYCYKLGLETGYTETVLGYTAMEGLQVTFNRSAGWIGFQTSDCGANARITGPYNTSTSLKTTCELIKPVAEVATSIQAAQWALCGISIIAASVLLYLLAPCIKNLCLRRMPRSQQISLSQTALVEEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLB1</accession>
    <name>A0A835GLB1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09567">
        <property type="entry name" value="SAM_kazrin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037614">
        <property type="entry name" value="Kazrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059089">
        <property type="entry name" value="Kazrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037615">
        <property type="entry name" value="Kazrin_SAM_rpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF1">
        <property type="entry name" value="KAZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25986">
        <property type="entry name" value="Kazrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="603"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="693"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114461" checksum="B79DB99FA0F24A71" modified="2021-09-29" version="1">MALVRRILGDAQAKLRKMVDEQVSVGARVDADAEPEPADPLITPASSALERPELDRPVPPERRLLIGTLDKRNGGLGVDKEGTINRTTRLSVRNGKDNPFIDDDNKENQANGKLESPVKWSTQNGSDSGTYAEIGNGGNSHTSERNILDPADSSEEEVPLPDATSPGRSSDGPEPRADITATLEGDAASPGGRSDRSRQEEVPASPGMLTAAQVARRLRMENERLQAELTRVRRLLVAAAERGEAGSTLLERAKSDTQDAPQLDPQQLEKELLLAREAVNSLKADKKRLKAEKFDLLNQMKQLYATLEDKEKELRDFIRNYEQMRSRGGASSALGAERAERERERAALLRHARDEAERSLQLAAALSARDTQLRHAREQLFEARRQLQAAGCLSEGESVASLGMGPPMMLGGPSGLIGDRGSCSADSGVRGSSDGGATSVCGGNLSDSTAEGAPPTLDAYDTDAASLVSSAHHIYQLSTPRDCSPTLSPHNSASPFTRSIDAGSLSRSVEQLSSPGECEAALLGGVRGRSGAGSKGARGRGSAWGSISRVFARSRHRTKSGSAAISGHESEPIYSGTGSTRAWSPLGSEAALREAASLPLSRWRAPAIIAWLELALGMPQYAAAVADNVKSGKIRALNGQVLLELSDADLEVGLGISQPMHRKKLRLAIEERRRPDLVRNPSIGQLTHAWVAAEWLPDLGLSQYAESFLANLVDARMLDTISKKELEKYLGVTRKFHQASIVHGIHLLRIMKYDRQALAVRRHQCENVDADPLVWTNQRFMRWAHNIDLGEFADNLKGKVARSVFANVIRTRTDGHVADNLMTTDSGVHGGLVVLEPSFTGETMATALGIPPSKSIIRRHLVAEFDALVIPARNLFGHQIRMLGRPFSRSVATGLPGIDLSGDSRRHSLRGSITRALGVLKPKHERTSPSSSSESSSVLSLTQPYQISYSPPIAVRTLSQLSMTYAPPPTLQEYEPIYTPLSLYSQSSVSTRDSLTRLNDIKENSSITHRYGQKADQAHRVSSPLPAKSADDAIIKQKRHRRVKSIGDINACTKAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLF9</accession>
    <name>A0A835GLF9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="46"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="442" mass="49729" checksum="DA8598CD645118F4" modified="2021-09-29" version="1">MREIVHVQAGQCGNQIGSKFWEIISDEHGVDPNGIYKGESDLQLERIKVYYNEASTGKYVPRAVLVDLEPGTMDSVRSGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVMDVIRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEFPDRIMNTFSVVPSPKVSEVVLEPYNATLSVHQLVENTDMSFCIDNEALYNICFRTLRLASPSYGDLNHLISLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARNSFNFRAQSVPELMSQMFSSSNMMTAADPRHGRYLTVATIFRGRIYFVEWIPNNLKVAVCDIPPRGLKMSATFIGNSTAIQEIFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAASNMADLISEYQQYQEANIDDEDIFDEEEEQHEEYQAEPREVSNTMAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLG6</accession>
    <name>A0A835GLG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLOD1-3-like GT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057589">
        <property type="entry name" value="GT_PLOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25342">
        <property type="entry name" value="GT_PLOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032381396" description="PLOD1-3-like GT domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PLOD1-3-like GT" evidence="2">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="410" mass="46689" checksum="DF7C13E7916EF8CF" modified="2021-09-29" version="1">MHRTERIVMFLQALSFLLLLSGLVEGRDDVKVLTVATDENHGLERFLRSAKVYGIDVEVLGRGTKWTGGDMNLPGGGQKINLLKEKLEEMSKSGTKEKIILFTDSYDVLFLASIDDILKKFQSFPETRVLFAAEQFCWPDTKLASQYPNIEVANPYLNSGGFIGYLPEIHEIVNHKPVSDKDDDQLYYTKIYLDKNLRETLKIKLDHNSAIFQNLNGALSDVQLKSNTSTETWPYIENVVTKQRPLIVHGNGPSKLMLNHFGNYLAKAWSASEGCALCDEKRIKLEEDNLPTVMMAVFIEQPTPFLEEFLDQVLTTDYPKEKIHLLLRNNVEYHETEVDDFFQAHSKQYATAKRIKPSDFISESEARNIAKDRCINSACDYLFSIDSVARLEANTLRHLLSSGYDVVARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMC1</accession>
    <name>A0A835GMC1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13600" checksum="272CE99100921BE3" modified="2021-09-29" version="1">MIRLASDNRVLGADVVKPKRGTKFLKEICQHSVGVLCWVEIVANSDLLSVYNRPIGSNLRLKNPVTFVRHALGPVTACQLLAPTRPAGVDWFPKWKGMRKQGLNPGGCLTCDPHCIICTTEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMP8</accession>
    <name>A0A835GMP8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c1, heme protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Complex III subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Complex III subunit IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome b-c1 complex subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HW555_004028</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">BAW_Kor-Di-RS1</strain>
            <tissue evidence="26">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="21">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="25">
        <location>
            <begin position="106"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="21">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF9419380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="35421" checksum="B39E3B6ABE033673" modified="2021-09-29" version="1">MTRSCQWNQLSLRRFSIMASAVGRICGARLLKNYGLVAPQVCQLSTGAQGWTRNRKLWLSTVGVVGTGVGALLFALEQSVQASGSEAHPPHQPWSHDGWFKSLDHASVRRGYEVYKQVCRACHSLQYIAFRNLVNVTHTEEEAKAEAAEAMIKDGPDEEGNYYERPGKLSDYLPSPYPNENAARAANNGAYPPDLSLICSGRKGGEDYIFALLTGYMDAPAGVVLREGQNYNPYFPGGAISMAQAAEYSDGTPATASQLAKDVATFLRWCSEPELDDRRLMTIKAIGMFSMLAVVTYYFKRHKWSTLKSRKLAYKPVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN19</accession>
    <name>A0A835GN19_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN19"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="263" mass="29144" checksum="37546E083153EFE9" modified="2021-09-29" version="1">MPQLAEVLSAQKSLEECFMKKMNALEAQIQTAGPAKDTVAKVAEEFRAFRDLVIGMLGLLRRQIGECSRQLDDIETRSRRKALIIQGIAEAAGEDCTNVTLGVINTKLGLNYTKSSIKVCHRLGQANTNHHRPILVRFASIDARIEHRPEEVKLNVFIRDQVPSTPTHNVLQEEPLLSDMTLDQMMSVRDPVESILPDEGTQQGSRTITTTSVNFIAREPSPNDNSGSPSILTDNTHRLNIEKILNLPNVTFADISPLPRAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNS1</accession>
    <name>A0A835GNS1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNS1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="347" mass="40986" checksum="061EE94E6BF3AD57" modified="2021-09-29" version="1">MDSMYYHIVPPEVSPTAQNTLNFDNYTDPDDLPPKNDSLLFDTFVSLLIEVSTEQLKNVKSNIMNTYDLHRSDVADVKMAFKDIEDKYTDIITTKLKTMLDGKPINITDHFMIDFMDVSNYILEKVLRYHIKNVKGKIESPTKWYRETLKEKILRQQTKIAFNYVENSVCETLQVCRDRYYYSDYLADWLRTLMNVTPRDLKRFFIPITDVLERHKYFIKSNIKFRQTIKYIINADAIVKRDTLDFLDEILTNPDKVLKSVPHGLKPSVTLLRELFSIIDGVYDVNDQNIEQLENITEMLRDWIEGNSFDVHKVLNAIVDNIRVNLQIWPLDIQNKIYYVWSEILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP47</accession>
    <name>A0A835GP47_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_010005</name>
        <name evidence="8" type="ORF">HW555_004020</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000322">
        <property type="protein sequence ID" value="KAH9639598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP47"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9639598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24470" checksum="7DEC6164D4F8C18D" modified="2021-09-29" version="1">MAVGDVKTAQGLNELNNFLADKSYVSGYTPTQADFQVFQQVGKAPSASLPHALRWYNQIASYSAEERKSWAAGASPLTAGGKTTTAPAPAAKDDDDDDVDLFGSGDEEEDAEAARIREERLKAYADKKSKKPALIAKSSIILDVKPWDDETDMKEMENQVRTIEMDGLLWGASKLVPVGYGINKLQIMCVIEDDKVSVDLLTEKIQEFEDFVQSVDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ59</accession>
    <name>A0A835GQ59_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ59"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="90" mass="10001" checksum="72ED570EBD925F19" modified="2021-09-29" version="1">MRCSSTAKMTYDSESLTCLSRYNWLDLAEMNIRNSSDPRLVRNQSYTDSPPTNPGLVQPPKKLSCLWELSSTQVVNPVVPVIVSSSKPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQE6</accession>
    <name>A0A835GQE6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fasciculation and elongation protein zeta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9423005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29485" checksum="5E09890FDF0956A5" modified="2021-09-29" version="1">MWWTITGNFGNILPIDWTKSFSRKMHIPTLNLNDKKSSMTPDDEIHSSEDEAVASDLDMHALILGGLHQDHECPVKTADEVIQEIDDMMQDTPSSEGDIIEYNEALEKGKEVLSSPLYEDKLRTYSLAQLNEIFMELEVLIREFSETLIAELALRDELEYEKELKNTFISLLLAVQNKRRQYHIEKKKRPQPPRSPNLNGGHTESKYLTTVIPFHLDNGPPDNQSLQVLIKILKAINEDSPTVPTLLTDYILKVLCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQI1</accession>
    <name>A0A835GQI1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP phosphodiesterase delta subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9423969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQI1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000004">
        <property type="entry name" value="protein unc-119 homolog A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF1">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="5">
        <location>
            <begin position="46"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="214" mass="24523" checksum="939311BEFD9E4A47" modified="2021-09-29" version="1">MSLVGKKCESISMLETNKDDVIVSEITPEDVLRLDRITDTYMCSPEANVYDIDFTRFKIRDLESGTVLFEIAKPPTDFGVDSEGTEDAPEEPLDPNAGRFVRYQFTPQFLKLKTVGATVEFTVGARPVNHFRMIEKHFFRDTLLKTFDFEFGFCIPFSRNTCEHIYEFPTLPPDLVDEMIAAPFETCSDSFYFVDNRLVMHNKADYAYNGGINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQX5</accession>
    <name>A0A835GQX5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="74" mass="7873" checksum="1B4460AB6E5C61BF" modified="2021-09-29" version="1">MALSVFVAGEDANSVFQGAIKPLIAECAKEYKLSDEELLKNRANEKSVGDGDAGCERAVLVATCYLEHKTAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR75</accession>
    <name>A0A835GR75_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="480" mass="53113" checksum="2B572CB7B36E9594" modified="2021-09-29" version="1">MSAPVRLSTCAAGRRPAVSFGECERLVLATVTQTKGYEFTMEPPSRTKEPPTPYRDARFKRKPGKEISQEALDKKQTTNGIDGAEIPGQAPEELHTASAMEGKDNSQRPPDVVMTTSQIKDTEHPQKSPEEVIIESSITDKENLLAPPDIVMTGNEMRDRDNITQLPEISTRNEIQGSEKLLTTNEQQSTECIYRRPEITLPAFDIQVATTSKARPEICAATASPRIPKRSRDQRPTSTKKELSTRAKIASILKAWKRGQRRRRARERMTKNLVRKMLGPGFWRDITVSDRNEAGGPGMQRSTPTCTATTARPHPPQIRATEYPQAHCSTTMSTSAAATTSEAIGIRATTSHTEIATTANKPSTTSAFEPKQGSPSDVIILDDDDSSDSDTIPIEEAIKHSPLAEMAAEMDAKDKVEARRKARENQNYDLQRELEKNKRMHEQVMKEMQQHLKTPVQTLGAAGLCGVFATPLPSLMEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS12</accession>
    <name>A0A835GS12_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore membrane glycoprotein 210</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1536"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="4">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1626" mass="175027" checksum="50283DCA79562A3F" modified="2021-09-29" version="1">MRSVDWSISASENIMEFKKTAVFLSVLCLLGCTCNGAKINTPRVLLPWFEDLNINFTFEIIEGGCYTWSLSRDDIIDLEPLYDDATGHCSRAARVSVSKSCVPPGSVIILAEEVNSGEILRGDVDIDKIRSLKVMSTTWNLFLEEAPEAFEVVAYDDQGNKFSTLEGISFTWSIENLGSNVGEDPLVTLVRWRDTDYEAPRGVTELEARGLRSHSVLLYGQAMGESRVTVCLEDICTDFNLQVIASVVLMPAIASIVPGDSLRYKVVRARAGRLTVQDITETVYYLKVPDTSIALLEDSVSLVKGTDIGTTNVYLMSGATEVATATLTVAEAHSIRVTLRPSNLVIKGEPFVVHCIVLDDKGHALMAGDQILIRLTVEGEANVDLLQSTENGTLTDAVANNAGSLTITARLYSVAGRTVSQKVEGQVSAVAIEPLEIVPPHLFVSWTDTLQEVSLKHIGGGDEPVIWSEIENELAPDPLSLTSDGIVTIRGPGQIGVRVQLKKYPHVKAIGKVLSAPFEMLQVSSSGYARVGKPHYLHIALTATHPETGELYNFHTCNCGSFAVSLLEGPEPQNVTVANWMKPIEGEALVPQSQDSRVAELSVRDGPPPHRYPDVQLFTFKCRRKGESVVELVSTAAEERESVTLEGGCAPHVSRVRLEAPDTPGNCSNPHKIWLRPGQELSVKVTLLDAIGRELLDENGPKMSWDIEPYHAGLQYQATDRLFVETHPDFVPVPVPYKYYQVVLADDTAIGWTGALKASIPEATASIQARVVAPLKCDPLKVNLAWESETVTNIATITGGSGRYAVEAPKGVLAEVEDGSLSANVLGPGSYDLIVTDLCVQGEKQLIEVHIEEVLSVEVTTSHAVGVGACVPVSALVKGVSHRYLTVGKPPEWRTSGYISVKDGSLCGLQEGTGKVRALFGGVWSPEVEVQVFPALAVVPSRPRLPPGSRVQLRHVGGPPPHLAQLHYRPTHGLPHVEVTPSGSVLGLSIGTSRIKLVATDFNNVEMASAEAVVEVVPISSIRVKAATQSLLVGSPSPLSIEAGGLSAAALASLMPPPRVTWSIRDPATARIYTSHADDMLERSVAEGLSVRVVPLKPGVITIDVRVRNMGQAAETRSWDSTIEILGLSDIRTSVEGLSKEISSGDRLALAVSSVIKLKSLPRGTWKAYGDGAVTISPAGELNAVRPGHAVIVAQHKDERNNIFRETAARYSLRMPMSALLDHSSVHGPELVIPDLDATGAFMTFQGTVSGVTVKDEVLVTGTDVKADRVVATGGWGVCVEGSGWRGPGGVALYSGGGVSLAVLARPAPATHVLRRDRPHALYTLHQLQLDKMEFLPGEWASELVPLSFTASGLSSGPLLCTEEQRYALEGTPIELPYNCRTKAPHTAEPVIDVINGQMGCKIIPASTVTEPSEVELCADWGTYRACTKTLLLPQIRVSTTKVSLLNPPATFTVMGHSHALKLVRLTPSPGLKLETNTENGEIIVIVTNEASTCGHGWVTVRSKLTSQELRVDVQRECDVACGTVLGALFSLLKPYMSTIVTVAAAAAAYLYIQQRMQRKAPIRMPTDPNETILPPDQSTPILNRSRTWSRSPYASSGPTAPVYGDASMLPEQSFSPNSTRNSMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSF0</accession>
    <name>A0A835GSF0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_000316</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9424505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="500" mass="57869" checksum="18AE4D1CC53768CA" modified="2021-09-29" version="1">MITVISCVVLLFLFIWFLIKWRNVKKFWSERGVPHYIPHPILGSLTFLQRQNPAVWMRQVYNEFKSPYVGMWAFWRPGLVINCPDLARKVLVKDHEVFKNRFLSSGKTDPIGGLNLFTVNDPTWSFLRRRLTVLFTAARLRSLNSLLSAKSNDLVKRIREDMANEDPLNLRVLCSDFTTDVIGEAAFGLTSESVRTGDSLMRQITKEFVKFNLHRGLCWSSIFFFPEMVDVFRFSLFPKDSVEVLRHIFRTIIDQRGGYEKEVKECRDLLDALLKMKQEAEEDNEEISEDLLLAQAAIFLLGGFDTSGVTLTWTLYELAWNPLCQERLYQELLEAKQKNDGKELDASALAELTYINCVIKEALRKFPSMGWLDRIASQDYKIDENLTIPKGTVVYVNSVGMQQDPKYFPNPHIYNPDRFLPENERNITPYTFLPFGDGPRGCIGKRFGYQTVRCGLASVILNYEIRTLPNMPKPNECHIEKHGLFLGPDKKLSVEFRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSG4</accession>
    <name>A0A835GSG4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSG4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45262" checksum="35DE14C3D1A81A0F" modified="2021-09-29" version="1">MTSRRKDYIFEPFKVTEVKYRGFDNPRPRSGHRIACDDTNVYCFGGYNPSLPPLPDRVRENPTWTPAQPLFKELWSFSIASRKWKHHRVTENMPEELASNAMCMNGKYLMIFGGTGAPFGNKCNNDVIVWHTSNEDNKLHILEATGVRPPAQYGQAIMCHDGCFYAIGGTNGFVYNCDIYRLDLRTLVWELVYLGTGQEGEPLGRYRHEIAHVGNKLYIIGGGTGDQAFELMEIPMFDFDTKTWTILTPKADDSSKDTITPLPRKCHSTVQIDTEHGTQVFVAGGSDGQSVFEDIWRLNISDLQWTLMQKTVLPHPLYFHSSAVTSSGCMFVFGGIEPKEDATCRNNIMYKVWLCLPKLSEICWEALLHFHPNLDQVDSRTLLNIGIPSHFVRRLQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GST7</accession>
    <name>A0A835GST7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GST7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF6">
        <property type="entry name" value="HEAD-SPECIFIC GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="120"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38288" checksum="29D0847DB238EA88" modified="2021-09-29" version="1">MGLEIKGQMVFCSESDSLLFVGSPFLDGLEGLTGRGLFISDIPLHDATRDVILVGEQARAQDGLRRRMDKLKNSIEEASKAVDKERQKNVSLLHLIFPPHIAKRLWLGEKIEAKSHDDVTMLFSDIVGFTSICATATPMMVIAMLEDLYSVFDIFCEELDVYKVETIGDAYCVASGLHRKIDTHAPQIAWMALRMVETCAQHLTHEGNPIKMRIGLHTGTVLAGVVGKTMLKYCLFGHNVTLANKFESGSEPLKINVSPTTYEWLIKFPGFEMEPRDRSCLPNSFPKDIPGTCYFLHKYLHPGTDPSASQVKHIQDALKDFNIGQTKPDDIENDESSGATESQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSY5</accession>
    <name>A0A835GSY5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSY5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="243" mass="26823" checksum="4B78E4ACA4107E81" modified="2021-09-29" version="1">MSQLAEVLSAQKTLEESFIKKMNALEAQIQTAGPAKDTVAKVAEEFRAFRELVFGMLGLLRRQISECAQQIDEIETRSRRKALIVQGVAEAASEDCTKVTLDVLNSKLGLGLTASSLKVCHRLGQANTNHHRPILVKFASVEAKMKVWRAKTGLRGSKLALKEFLTKTRQSVFGKARQHFGMRSCWTLDGVIFIKAPDGSRHKVMSLDELGLLLGRYPRAQDTSTSADKRATEVLGGLKGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUG6</accession>
    <name>A0A835GUG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal protein NCU-G1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032453242" description="Lysosomal protein NCU-G1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9424523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44882" checksum="F054CA8F8BC3C10D" modified="2021-09-29" version="1">MIRMHLQTLLIVFILSFACGQDRRIIPKLNPGCDNCGTSTTLLYIRADGSQDTVHQLWDFTRGMPTIIYVISKLNTSLTINWRFNEPLEFKLSEKPLYSFAVTLDKLTEYNDIENNGYIDNRCPQRALSLRDLEWTRGSTVLDNKEAMLHMRGKFGEHNQHGVIDMKLDLLPFKDYAVDLPHLIHTANSTLVDVSLVNLTSSADYNASRFALHFTVVSTDPRNENMSYSMRKSLDDEHTPGVFEIFEIRTPKSSRSDDGGFIQFRPVSYTEQERSVSSSTNAYISNFTWTTIPKTSTLRVFYEQFDKDNLLVQDMFISFGLPGDGFYRQHNFTSWSFTIGYGIPPVESFSLFVIIIISIGLGVPILLALSGITFVIVRRCKQRNPPARFTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUR5</accession>
    <name>A0A835GUR5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUR5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032809339" evidence="2">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="219" mass="24336" checksum="97B89F98A5405B97" modified="2021-09-29" version="1">MKLIVTLFLIVALADLFHCTPTVLKGNDVANLNNDNPTEAKPVLNSNTETNENVEPKVEDNDATTIEPVITNTEVKGPVDAKEPSSNTENASSPKAPNPEPQQPNSVHSLPRFNPRQYPGFYPVQNPVPYPGLNSVQQAVLIPSQQPPQYQLPQAEQNLGQPPQLFPLYLQQQQPMIFGGQSPLQMPDPYALYPVPYPTLYQQQYSPNYDYPTFSVLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVE6</accession>
    <name>A0A835GVE6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiosis regulator and mRNA stability factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Limkain-b1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905762">
        <property type="term" value="F:CCR4-NOT complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034189">
        <property type="entry name" value="MARF1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11608">
        <property type="entry name" value="RRM_MARF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032395545" description="Meiosis regulator and mRNA stability factor 1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="300"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="13">
        <location>
            <begin position="727"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="13">
        <location>
            <begin position="803"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="13">
        <location>
            <begin position="884"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1230" mass="136345" checksum="FEF658C855FCCF25" modified="2021-09-29" version="1">MKILFFVVCKLVKILFGESEYFFVFFLQHMLDYFCSLQITRNKLFCTRTMIASVNCDNLGSNNSKGTRSHSAQGLASSVSSSAMKIPLPPRPWITDAEDDSSDEMDSVIIKDESLIAMERTRMRSRYRHHKQRQVNVPIGIFWDIENCQIPRGCSAIELVAAIRAKFVRDGRREADFVVVCDVRKETTTRLLELNDAQVSLIHVCRTQKNASDDKLRQCMRRFGDLHSSPAAILLISGDIDFAADLTDFRYRKNMEVILVHKQNTSAALIACASSHYCFDEIASTLPRKVSKSEEETPTCEVEVLNLPIHQPAELVSIRLRHLAKKCGGKVVSVTAPTAVLKFSTPDHASRALMRMDGEDVYGRKISTRYARSAVPPAYSSDEGYSTAPASYQAPAFVPPPAKVCSSPQEMASFNTPCISKEWAMALKQLPAPTPPPHDFCPPPAPKPRKIRGTHGDADSAVQLILTVWAAGEGPLATVVLRSEWDARLAIARIHKRRLDNQWTGRRLELSLGKPSPAPNLDVLRARLRAILLDQKNHTLPLLRLRDAYASRHCCALTTSDIAKLKDTVVIHEGFGRMVQLVDLTPVSSSEMEEAPWKCHIHASMSTGQEDGSRILQPVYMEISTLAKNVHILLESHGGILPLLSFVECYESRFDALVCDPRHGVALELLLRSVEGLDVRDAPSRHLTWKARPLALTPPLPQAANSESSRSSGERERPRTAPALEPMLALFERELIDLLRTAPRCSIPFSKLIPAFHHHFGRQCRVADYGFTKLPDLLAALGNAIVVLGSGSSRIITISAAAQSRRWTSDLVKVLKGQPGRAVQLHELPQLYHAVTGRPFSPVDYGVCTIAELMQRVNPQAVTVAADGTISLPRRLPTPEERARTREFAMQAVELLRHTANLRMEFSRFVPAYHAHFGRQLRVAHYGCVKLLELFELIPEAVAVSGAGAAERSVRLRGGVARALLARRLRALPALPLRDLPLHYAHHYGAPPQPDMLEADTLEGLVYAAGGCIENNVVVAPGGSPAWAGCLLTACAVLCGDRSVARGSTLEYFTAAYRRLRGAEPELRRLIAAGVITLSEQRLNVSPEWRVVWRLAQLLTDRATPASAEEIFIEFARRYEPVFPGVDPSAEGVADFLRHYMEIFTETETGRWTLCPGVVVPRCRELIPGPAHEDYSVHDTPPGQKGSRVFESPKNNIWCSPPASALPTPTAFLNLENRRRIRLAAHFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVE7</accession>
    <name>A0A835GVE7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="414"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="583" mass="66689" checksum="C2F0F2599E26CB8D" modified="2021-09-29" version="1">MIHDALLILWDCSHTTEGQKELVTYANHGDQEIFARITDIAKSHHKIQCFVEATGFYSRKSHIGLRLCGLYSQALSEGFTEVLQSYKKNLMEVEGLVIGNHNYTLSFVYSYVEKYRGLFNTLNKIITTIEHRKLIGCQILSLLHQYILNGSEKVREAILRIFSCVNKVFVNQLCTWLLYGELKDPYHEFFILNNQAQDASDTFLSSPSTTNTCDKSLVSTLQDTTLECGYALNTSMIPYFVPLSLAQEILFIGKTIILFGFDPKKALIPKLAHRAHDLVRARSRIPDVAVEEAQLIHELRLMKDFYLLGRGELFLELLRLTAHMLDKPTARTSTRDMNHAFQLAARAVFLSNSADIEKFSFELPYVKPNISANTTIDDDSATVADGWSSIILKYDFKWPLHLLFTPEVLARFQMCQLHNKLMFLMDNLQHYMQADVLETNFARLMDAVHKTNDFEKLKKAHANFLADVLSQSFLTVTSSGDSDSSDLADALNNPVFCNIMELLKLCHSFCGMNDTVDDKEAEDYYIKGYSDRKLVKQLMQLLVSLRDRPCGVYLARLLMRLDYNRWLSGEAQLTQSVTNMLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KW86</accession>
    <name>A0A835KW86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000904">
        <property type="protein sequence ID" value="KAF9404700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KW86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="445"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1024" mass="117184" checksum="A83739129D0B5DD6" modified="2021-09-29" version="1">MLSTSQPRYIVHGDLIKLPSVVALAECKGDAKLDISCCHNPRNLSVVNLYDDGVQGGILDLSEEGFRFEIENCVALNVDRGAKRPDVLGVEEIVPRALDHNVTVVGLTEEDFLNLFPVVGPVLAEKANMGRPTKRASRMRQRRLNETSEDHEKRLSQSRKTTAKAILNENSEKREKRLSQMRTYMKKVLDSENPKRRTYRLGLIQDRLSNETEEQRTHRLSLISDRLSNETQKQRAHRLGLIHDRLNNETEEQRTRRLGSMQDRLANETETTCPSLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLRLISDRLSNETEEHVHRLGLIHDRLSNETPEARLNRLNTMRQTSHIRRDITNEQSFQTAINVFADVSCDVCKKNIYPQQRFNLRPNMYNTLLPEELIALDKITTCSRCNNHIKKRKIPPTAYWNKMMPAEIPPELANLTSFEERFLCRIVPFLKIMKLNNRFSQNWCKGQVILFAKDVVEIADQLPLTPHQAGLILVVESLEDLSSSKEFVVDTQRLNKALTWLISNNHLYRDVQHILNLRQTLLQDGTEETSSNQYVIINDNKAILRGSFHQGDLRFNSSRGKQCTGIAAVACVAFTVLDPNNWSKSDIDYILIIGDKYYNDCIASRNNPAFGEMNPDYLAVTDLMPSLVYNRQNIAITVLEETNINGHLDNDNSSDGFPNLRNALRSFFTEYSSGILTTNAISVAVHYRTSYYYLFDSHARGAKGSSAPINGAACCMRFTDLDDLHTVLRRNLYVSPNKPSGGNLRDNLNVYSLTPLVVAVDNQMRSFRPISEQSAIEMMESPTFTPSLINLLQPPIQVIESVQKTLQSALAQGSEIQLPITANNSLNTIYIESTSMLQNIDDNVPNLESVVGVNTSLTDDTMRLAAITRKTAPPLNLERERRMEELCWYFIYPDGKNGFGEERENPVTPLDYFQNRIMNSFKQKQRISRNSKPLNHLKNVNKDMKELKQDNIKVKKKCQETENEIPSHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXK4</accession>
    <name>A0A835KXK4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000833">
        <property type="protein sequence ID" value="KAF9405029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032732785" description="Citrate transporter-like domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="192" mass="20817" checksum="996AE86B01D0E7CE" modified="2021-09-29" version="1" fragment="single">RVSLGWTALLGALLLLTLADREDLESVLHRVEWSTLLFFAALFVLMEALSKLGLIGYIGGWTEALILGVDESDRLAVALILMVWVSGITSAFVDNVPLTTMMVRVVTSLGTHPTLNLPIEPLIWALSFGVCLGGNGTLIGASSNVVCVGLAEQHGYKITFMQFFKIGFPVMIGHLVVATAYLLVCHCVFSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYA0</accession>
    <name>A0A835KYA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013822</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000741">
        <property type="protein sequence ID" value="KAF9405438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="235"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9405438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="436" mass="48310" checksum="0F94F3D4ED1FAABE" modified="2021-09-29" version="1">MVIMPAMAEQNDILKTILFSFNVFVHMLVGITMGVPMLYAVLQNFQTDAADSEAIMHHILICIPAYQVLAAQALLSLCPFNTWSSPLKKSNKIRAHWVLHLCAYTMGVIGSVIILSSKKKHFETTHGRLGLCCLTITPLTMLTGLLCLYAYPLRRFCPVKINKLIHVVIGMACFACSSAAVCFGFDKEAFRDWMNERVTNGFIAFTGIVTSILLFNPLITVFRLIYKILNRDCHSLNIICHTLIGIVVGVILTYAFNLPSGKTKDHIILCVLGYQLLMAQAILSLSPHNGWSAHLKLVDKKRAHWILQVVGSVLAIVGSFIKIIDKNIHWNTNHGIFALIALVFTTISLVNGLTSLYAYEFRRFLPSNLSKLTHICAGTIAFLAACISLSFGIDKGMFTGWAGSTLSNVLIGFNAFFTFVIIATPLINFFTKLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYK4</accession>
    <name>A0A835KYK4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000546">
        <property type="protein sequence ID" value="KAF9406803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="33847" checksum="8DEA87B1A2647A34" modified="2021-09-29" version="1">MSFCDEDCETLIELIRQHPPLYNAQLDSYRDENLKDNIWKSIAESINKTENTPSERQSCTSVEQEQQSSASVEKEVTNTSPGVEHADTPHEAADTSVHNTPSKELPGTSQSTQEKSNIPSNSSAKNTKRKRPKEDEYIKFMKDRQENRNRQLESLKSQESVDDISTFTKHIEMMLRKLSARSRAMAKSEIFNIVSKYEITDIESQTERPYTCSPYNSHFPTIAALSGPQAQSDSSRQLSYNSNSSYNSYSPISAASSEHQTQTGLIDLTSRQLPNISGEPFQSNYGEIDQNNFEELANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYM5</accession>
    <name>A0A835KYM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="28924" checksum="874AB9701662565C" modified="2021-09-29" version="1">MLRKSYSLHKFRNSLKPFLLVTSDGYIIDVLGPYPAVTSDANIMHNIMNQDDHLLHWLIHRGDVFILDRGFRDSIYDIQSLGYEARIPPSKDRNATQLTTEQANKSRLITICRWVVEAVNGKFKNRFKLLRQSYFNKALPNMFIDFRIAAAIINVCYRVATDSRLASEILNIIQAENNTPNLLRDYVEMKNLNRQRVTFTAMEAQMPNLKSFERLNEDDIILFALGSYHLKLAKSYCAEHFRNGLYIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYV7</accession>
    <name>A0A835KYV7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_014435</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="JACKWZ010001032">
        <property type="protein sequence ID" value="KAF9404258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="357"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9404258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="667" mass="71982" checksum="4FBF4CEDB80DADCB" modified="2021-09-29" version="1">MIFLFDNTDQLGVNTIRTLSIEAVQKANSGHPGLPMGAAPMAYALWTKHLKVNPKTSTNWADRDRFILSAGHGSAMLYSLLHLAGYNVTIDDLKSFRQWNSKTPGHPEVHHTDGVEATTGPLGQGIAMAVGMAMAEAHTAATYNRDSFPVIDHFTYALCGDGDLMEGVSQEASSMAGHMKLGKLIVLYDSNDISLDGPTSKAFTENVGARYEAYGWQHILVKDGNDLEAISAAIEKAKAETDKPTLIEVKTVIGYGAPKEGTSSVHGAPIGADGITAAKAVYGWEYPDFTVPEEVGVRFKESIVDEGEKAEDHWNKMFGNYEKEHPELAKQFKQAFADELPENWDAELPTYEVGTSAASRVTSKETIQAISKAVPSFWGGSADLSASNNTMVAAEKDFEPGQYEGRNIWFGVREFAMASAMNGIQLHGGSRIYGGTFFVFTDYLRPAVRLAAIQNTPVTYVLTHDSVAVGEDGPTHEPVEQLASVRCMPGVQVIRPADGNETVAAWKIAMTTKDAPTILVLSRQNLPVIEGTKEKATDFVQKGAYVISPQKGEKPAGILIATGSEVNLAIDAQKALAEQGKDVSVVSMPSFDLFEKQSAEYKESVLPKEITNRVAIEAASPFGWERYVGSAGSTVTINHFGASAPGDLVLKEFGFTVENVVATFNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZP8</accession>
    <name>A0A835KZP8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_011722</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZP8"/>
    <dbReference type="SMR" id="A0A835KZP8"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="175"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9408658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="295" mass="32188" checksum="E1EEC9F06EFC1014" modified="2021-09-29" version="1" fragment="single">VDMIFASFIRNGAALQEIRNILGEKGKNIKIISKIENHQGMVNLDEIITASDGIMVARGDLGIEIPPEKVFLAQKTMIARCNRVGKPVICATQMLESMVKKPRPTRAEISDVANAILDGADCVMLSGETAKGDYPLECVLTMANICKEAEAAIWHRQLFNDLVVEVKPPIEPAHSTAIAAVEASTKCLAAAIVVITTSGKSAYLLSKYRPRCPIIAVTRQAQTARQAHLYRGVLPIVYQEPTAQDWLKDVDNRVQSGLKFGRARGFIKTGDSVVVVTGWKQGSGFTNTMRVIQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L047</accession>
    <name>A0A835L047_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centromere protein J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000570">
        <property type="protein sequence ID" value="KAF9406617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L047"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009852">
        <property type="entry name" value="CENPJ_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026581">
        <property type="entry name" value="TCP10L/CENPJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058029">
        <property type="entry name" value="Tubulin-bd_CENPJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331:SF6">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10331">
        <property type="entry name" value="T COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07202">
        <property type="entry name" value="Tcp10_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25779">
        <property type="entry name" value="Tubulin-bind_CPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENPJ tubulin-binding region" evidence="5">
        <location>
            <begin position="176"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere protein J C-terminal" evidence="4">
        <location>
            <begin position="1144"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="837"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="603"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1217" mass="139063" checksum="D8CF91BE567049FD" modified="2021-09-29" version="1">MDETYSESDVSLSPSQILERLQVLRQLQLMQRGKLQKQRLEYKETSESSSSITEIVSHFSNTTSYNTFRSLLESSNDISNEGTPRVNGNEVSPKVQERDLIDGVSVLNLSQESECIVNSPLSGRSRASAPSRNVGEIPSEPSQNTSNKTSVNSSLNKNPHVKKQISLDEMPILSPKKDFEALLIEKLQSEKTAPKSKSPNKDNSVNTNNKRPFLRRGEGIARFGLRKNDFVIQNTKSLPWKRKSFQNKTESPLKSNLKKLKEKNNNASTETTNVQNKKSDNVQSGMKKLEKDDAVATSEPSLLVTEIQQAKLVRKNQTKPRISDTNNEPEATSKIAENKPTSMEPSTPINRNLPFNKPLPRAEFPKNKHPLIANKGKSWAAVLTQEQNDFLSQLKQSDYYKNFVSPSKSVISDASCDETMTKLRYDRETAEQKMFELLENKVTHDSFSLENSFFDRFLRSNLESSTESTPLMLQKCLAQNPKLINILPGLKGRIRNENSHSDAESCYSNCTDCSEACSSCCSCKNVDQSNYSANKSPCVEQNKNVKIIQPKSKAAKINEKEDESKECHDDTMTETDVMKANMAEMNAKLISTSELLKDRLCELEDEIATFKKENSNLAKLREEIDHDRQKFYEEKAAFEQKFNEEKVLSEYYLAEEKEKLNKQKQIYERYVREMRGRLNKKDKDEVVNLKKEINDLKEEIRIKDAKSTSTIARLRNQIKIMEKEKKDLQEEVEKLKKQNKRIQHSNEVTRRLTNIKYLEEINKKLTNMTNKDNRSEVSEDRDIKYKAYEIERQSRSRRVEPVGKSVIRPRAKSVPNLNVTSRYAKYFSQRDTLSQIEQNKLPNVERIDYSDDETEERDNDTISNESLDEDDRNNDSNNLEKIYTERFKSSSPKSSRSSGSSLNFELNLNEKPNLNDNARSFFLQKSNSGLSRTSKSPRRTISPCFNKNETVINRAKSPISILSNKSSKSPPSRNSMEYLSSRSGSNTTQNRSKSPGSSYNNSSMKSVTVIHNEQYRDKLMNLSPEPSISKTNLSKTSLNPTEVRKPDGSKELRFPNGNIKYISADGKYSKFVYYNGDVKENFYNEGRIKYFYAETKTYHTTHADGLEVLEFPDGQVEKRYKDGSSEIRLPNGSVRYFDPKNEHVREEWRFPDGAALTVSASGEQRIVFSNGQVERREFPDGTVKLVYSDGTSETRYASGRVRIKDKHGNLIMDSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L052</accession>
    <name>A0A835L052_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000568">
        <property type="protein sequence ID" value="KAF9406638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="507"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1356" mass="155480" checksum="1714D81ADD2838A9" modified="2021-09-29" version="1" fragment="single">RQSEIISSITTIKVNFNKDSDSRKNAEYIKKRLGALDALWEEFEQNHSRISDHASEADEYFRLNTYQVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQRTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKRELNRKISSTTHLEKVTPKLEIPTFSGNYSQWPTFYDLFSETIHNNNSITKAQKMQHLKGKLKGEAERLIYHLNVSSENYDTAWEILVHRYNNEQALFTHQIEIFLNQPNIQKQSSSEIKRLYDTTTECIHAIHNLGVNTNAWDPLLVHLLCKKLDTDTQTDYREARVEPRKLPKLDELMTFLEGKFTALEQITKYDKEPATSIKRTPNPKVQNNYYKYNNYKGFNHRNYQAQAIHISKCAVCNLNHNRNLFSCKKFINMTPDLQMRIVTQSNICKNCLFSHDGNECTSTKRCKSCQGNHHTILHEALDDEELLLTTLSINVRCSDGTYITLRALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQKALRLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLLDVSIYSQIIMDGLIKGPSQAPIAQQTALGWILSGNVRTFNCHIVTNNISDLSKYWEIEDGPKWIIHFDRNTLPVTSYQSPNIEIKKHCVNTALYKNNISVIQELLCNYSSLTRIVKIVAWISRFIKRSRGKHTGGTEFLTSAELHNALHLIIQNYQLYEFHEDIQFINQKGYVHPKNENQAIYFDRLSNLQYIKDEWRLVVYYNMTTYWKGLSDIKSYVNHIKTMCITHSSKQYQSIIVQLEQEISEIEHYDMLLKNTNEAPMRLRRGLVNGVGYIANSLFGVLDERFAEKYKSDIEQISHNEKHLQNLIKNQTSIMESEFNILRRNENVMNKQFSFINQRLQDLAREVYEVRLVNQDNNYITSSSLAASIILSNLRWIQQTLIGTVTDISHGRIDSHLLSPEQLSYQLSIISSQLNGKLTIPVDIKNIKDLYRLLKVSARVISNYLIIEIKIPLLSNEMFELNKIISISQKQGQHYYQFLTSVSFIAYNLHKDTAFLLSEEDLKSCTHIPSDILLCSLNMPIYDLKMKQSICDIKIINHAHLCKSVKSSCEERWIKLHRPNTWLYTCCPECQVRIICANGVTMTHLINNGIITLGQGCTLKGDTFSIYAHNNFFSNLNIHHHIEVPEVSMLNRIMKTSIPDNISMVEDHQVIWDQLRAQIDEVKEQSSTDLSIHDVHHYTVLYISVAAVIILGGVVVYLIRSRRAAARAAASPAPQGQEAAGAGPATVAPVDPAPVASHQARSVLKCSEVFTVSGVGIFYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L080</accession>
    <name>A0A835L080_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000378">
        <property type="protein sequence ID" value="KAF9408514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L080"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF142">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032603438" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="849"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122562" checksum="45DBF6BD761E6B4C" modified="2021-09-29" version="1">MRWSTITFILLPIIFASTTAEWSWGGKEDSKTADESQQNASPLLQGEQLPEAQEKNFESNSTVLDDIVDELVSSKQGRSLGGFDDVYSDPTIKEALDSGDDAEARNLIKGRLCTLGLIQCEDEDSQEKRTYLSPDEVIYAQPVDIKPIGKPIASIPVRGPPRAYGPPQPMSYRPRPQKIPPKRVGYGGNVRPGFSDKYGVAGGNFQFSQNSALYNAHESNFVTKSPIYATPGPYAYENTKPAYNKYPSHSDTKTDTVVQQHIHHHYVHEDNKDPKVIIKPVAIPVGSVGQLNTQSFGSQFSGSQSSDIISGGGDYSSITSGGFKPMSGGFNPDTKPIYESDTIYGSQYGHQSNKVGHNGNILTQGLPNQFNNNAFEDQKYGNGLGSYASQNNEFYKKELHVGSQNNIYNQGPSTFGQSNGYAENYHEAKAQNFDCVCVNYDQCPSQEVIGRRDDLYLPIDPRNKASEISALTEEQLDNLNKTDTAPTTAESTTNATETKKLSKRETKEETPSEAAKEAEPRSPRYPGFNEHTGHDQKHVEPTFGVSFALPQGPQTSNFHPLNPHLHPFSNAIMAGGINLGLAVVNPLLSLQVTKTVEGEKIYKPLLHFHVTPSQNKLRAITQIFDEKKQYLLNKHQHYHVHQPFPPVYPINPGPAYPPHYPPPRPHYPHPPPNYVPPHVHNGPPIYSPHYTDYKPYSYHGNSLPSGGYHDYEDDSDPNYDSEDYPQPYYRSLHYNDRLEKVTDVSDQATHVNRSSYSRSLNLPSTPPRANRGYQTIRFPETRRKREIDVGNMSVIIEERQGYFGRPPVQQCRPNQVCCRRPLQPQAANKGQCGIRHSQGINGRIKTPAYVDGESEFGEYPWQTAILKKDPKESVYVCGGTLIDGLHILTAAHCVKSYKGFELRVRLGEWDVNRDVEFYPYIERDIVSVHVHPLYYAGTLDNDLAILKMDHPVEWTKYPHISPACLPDKYTDYSGQRCWTTGWGKDAFGDYGKYQNILKEVDVPILSHGQCQQQLRQTRLGYNYELNPGFTCAGGEEGKDACKGDGGGPLVCERSGTWQIVGVVSWGIGCGQPGVPGVYVKVAHYLDWISQITGKFSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1E1</accession>
    <name>A0A835L1E1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032727867" evidence="2">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="204" mass="23755" checksum="386CF0A4AF0C5009" modified="2021-09-29" version="1" fragment="single">ARSAPELLANAHFARKLLIIINFIVVSWNPCYSQYESGTSKRILDKLINMIKEIFTDAIVKLEQIEVFKLEVEKHRAYKQGHLEYLVKDRYRRMLILYRHTDRLTQKNKDAQCINELVDMDNLYHDTMIFIEMMKMIEGVDNLAPIKPRFRSNTAQKEWREAADTAANDPAKLTKNPQSSETPSGKRSNGAWNYGQNSDDTLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1H3</accession>
    <name>A0A835L1H3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000227">
        <property type="protein sequence ID" value="KAF9411371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1H3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="173"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="757"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="665"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9411371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115598" checksum="4B0B97AAB67E1F4B" modified="2021-09-29" version="1">MGTTGQSITLANSIIGVGILAMPFCFQQCGVLLATSILVFMGLISRLCCYFLLKSALLARRRNFEFLAFHVFGQAGKIAVEVGIIGFLMGTCIAYFVVVGDLGPQIIAKMFNINQSDILRTSIMVIVSLVIFEAGFVMMSSDWASRVEMWRPAGCCNACQFSPWHSSVKRKQLFEIFESLPSLSLEKMNVVTKNAINICTAVYFTLGVFGYVAFASHDISGNILMSLSPTMASDVIKLGFVMSLAFSFPLIIFPCRASLYSFLYKKNSRQPISTSYSHERCFNEDTLRDIIKEELAAAVKSSFKDLLTDQLKNIQGEISAFKVSFGFFNEQFEEFKKRFEEKDAIINQLRSDNTKLQQNVIDLTTRLCIVEQNMRESNVEINGLPEDKSENLVETLKNIAKVHSSHHDHIINHSIPEATFRCITVGIIGVALFISLLIPNIELVLGLVGSTIGVLICVVFPAACFVNVTFKNTNERVLAKGVLVLGLVIMVLGTYANLQAAETSIERYDDKYTQEKIDKIVEDFFESRVKQDMYLNQPQNDLQKEVENNIVIDNGVRKDSEVQPPNPVPPESQSNEKIILSKNILKTEEKKPPPLPEPKEIIDKVSETHPRNLKNKLEQANGASNGEAKPKEVKTQSNEDKIDIMKQQQLIETIKQHGEEQKELIKEQKEILDEILKTKKELQQNKNEAEEAKAKKIAVESIKQIADIAIKSIGGVTEKPDVVQDDVKNERLEKMTNDAVQEIAKKAVETIEAIQEIKEKPEQPAQAVESKPAQDIAGNRPAQAVENNLPQKVNGEANPAQNGQPSQNKPQAPADPPVLNAIPPLVNGKVEQPIAAANDVPQVNKLVQNNGAAIPSNVAPVNQVKRDINEANNAQMANNIVDSKVQIPEAEAKHSHSPDEPQSYKQGEDTQGIAEKRIVQKLPPPIVNELAHNKIKIDRKPLAQVDNIKVMAAQSNGVNSKDEANGKPALVRAKREVVDCTKTISLKPEDRAICKAMAVSKESQEILKSVDMNEIALPKSLPEDANLLHHIRSLKSFEKDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L222</accession>
    <name>A0A835L222_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_002530</name>
        <name evidence="4" type="ORF">HW555_008067</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000150">
        <property type="protein sequence ID" value="KAF9413799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000859">
        <property type="protein sequence ID" value="KAH9629594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L222"/>
    <dbReference type="SMR" id="A0A835L222"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9629594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="73" mass="8580" checksum="0471BAD71AFED8F1" modified="2021-09-29" version="1">MLEVTCNDRLGKKVRVKCNPDDTVGDLKKLIAAQTGTRYDKIVLKKWYTVFKDHIKLSDYEIHDGMNLELYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2F1</accession>
    <name>A0A835L2F1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2F1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="415"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9412792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="488" mass="55185" checksum="6BC05AF7524C0849" modified="2021-09-29" version="1">MSESSKSKSSLNLNPSPTLQCKDLHEYLKSRSAQFLETLYNYPTICLAVYRELPELARHFVIRLLFVEQPVPQAVVTSWVSQTFAKEQAKACEALSELSVWQEAPIPGGMPGWMLAQSFKKNLKVALLGGGRAWSMSSSLEPDGKARDVAFLDAYALERWECVLHYMVGSAQTEGISADAVRILLHAGLMTRDAEDGSAVITRAGFQFLLLSTAKQVWLFLQHYLHTAEKRSLSAAECLAFLYQLSFSTLGKDYSTEGMSNNMLVFLQHLREFGLVYQRKRKAGRFYPTRLALNIAQVRGVGATPLAAPAQARGYIVVETNYRVYAYTQTNLQVALLGLFTELMYRFPNLVVGVLTRESVRQALRGGITAEQIIHYLEQHSHPQASCLIISQNYMLKSETGGIRTTSMLPPTVVDQIKLWETERNRFTYTEGVVYNQFLSQADFVVLRDYAKQQGVLTWQNERSRTMVVTRHGHDDVKKFWKRYSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3A6</accession>
    <name>A0A835L3A6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3A6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="241" mass="28244" checksum="7B844E937368C030" modified="2021-09-29" version="1" fragment="single">FNKTVFNQHQENFRETRTILKEVYHKLQDIEKLLRANEEVVITKQDSVVNRANSLFDTYSKRIKQYKLPEDFKRANRKSSSPTYLYCNEEIAKNTVAPPELHLRTEQDYYRQLEDYNEGYLVVFMMELARLVAVKDLADVRSILRHTDSILFETLKSGKLGSLGYPVTHVLLKFGVFVSDEPTAVVRMTRTSAEVCQSLVDSFFAPYRRLLRTGKRHILLDAINYMLKIRFPNRNQSLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3L9</accession>
    <name>A0A835L3L9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3L9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="13474" checksum="68F0D392B506AF03" modified="2021-09-29" version="1">MNEATRSLVSDRNSPKQVNSESYSSDVVISNRCFWCCVNATSHVSETMTMTVLTQYINQIYTFLDLFIYPFMNSRSCSMIWASLIDKMATQKENRGGFKSVYTCFVNCVRTSIPLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3T9</accession>
    <name>A0A835L3T9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000149">
        <property type="protein sequence ID" value="KAF9413856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3T9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000069">
        <property type="entry name" value="CUGBP Elav-like family member 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="172"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="27493" checksum="D2431FBC6C403E85" modified="2021-09-29" version="1">MAKGASSSLVVKFADTEKERQLRRMQQMAGNMSLLNPFVFNQFGAYSTYAQVITEQQQAALMVAATAQGYISPMTALASHALNGMSNTVVPPSSDNFSGLAIGTGAVPVTAQGLPNGEAAALQHAAYPGMQPFPGVAYPAVYGQFPQPIPPPMSTIAPAQREGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L477</accession>
    <name>A0A835L477_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L477"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF169">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-16-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032960918" description="Peptidase metallopeptidase domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="11">
        <location>
            <begin position="116"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="309"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="414" mass="47365" checksum="F04B1280377756C6" modified="2021-09-29" version="1">MIVRSVLCILSLLCCTCVTAKAVYYEEKPPTPEELTFLKKYGYLSAPDDLGVGDEADYAYTPHSISDALKKMQAFASLPETGTLDPETKQLFKKKRCGVKDIETSTASSRSRRYILQQAWNKKYITYRVVNGSSTMNKSRVEEWMEVGLGIWAPHGDLRFSRIEEGRADIQVSFVSGDHGDGFPFDGPGHVVAHAFPPPHGAMHFDDEETWGDNPEEEDEEVTDFFAVAVHEIGHALGLSHSNEKSSVMYPYYQVPVERLHMDDILGMQELYLKDQETSGESTEGPVSQTSLVPRFTKAGSEEDENYMPDLCLTNYDTLQVINDKIFVFEEEWVWVLRDRHEMEEGYPKRFHDVFRGLPLNVNIIKTIYQRQNGDVLIFSGKLTVDAKYFLFYYSFKVIVPTGSERQFFEWKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4V4</accession>
    <name>A0A835L4V4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4V4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF16">
        <property type="entry name" value="PROTEIN SPAETZLE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spaetzle" evidence="4">
        <location>
            <begin position="286"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="384" mass="43623" checksum="F4878A9D1C42E267" modified="2021-09-29" version="1">MKIAWLSIQSGDGYSCPYGQHCALEPAPPGKTPPCAQPGLTYCVHPEPYPEKIIRQLIEAGQYDISTLLSDETRDEFSLKKNDYPYDYGPNSLPHVDQISLVNDPHYQKNYKFHTRYNHDIFSQKTPLQPPTASDPTPYNINAYHASNFSKFGFHGYSPNGYWNPTRSFGDYDKKVLRQSAFNQNFFEPTNFYPNYESHEWFRPSSSGVSQYVSPSRSDVTIERSVTFPTRTATVRRRKRNAELVKAAEKRTLTGAEALRIALGLANEDFSAERRRRQAATPNTQTLCSVRTEFIPIRAALNNKGNWKYVVNMPDNMSQLVRAEICTSTTCSGICTVPPGYTSRCEQKYIQKRLVALQSSGQNLYTDLFWIPSCCQCTFTANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5F2</accession>
    <name>A0A835L5F2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5F2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001898">
        <property type="entry name" value="Ribosome biogenesis protein WDR12 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="41938" checksum="F83CDA4A2F667E46" modified="2021-09-29" version="1" fragment="single">LHRGQSSIVYHGPRLVKRQVSDTLSFHESTNMSAEVAEVQLQVRFITKQEQYAVPDSPYAIQSNVQVADLNTLINALILSGCYDNSIHIWSTKGQHKLAIPGHTSPVKAVSWVSLDADQAVFVSGSHDQSAMLWVWNVPRNSVDCVVTCRGHEKGIECLAVSADASRFATGSWDNNVNLWSTSLAEEENVPAKKKSKPEHGKAREPLTTLKGHREAVSGVQWMDYNTVLSSGWDHLLKLWDCELGGIKQEIAGNKAFFDADWSPLNNSIITASADRHIRLYDPRSTESIVKTTFTSHTGWVQSVRWSKTRDTLFLSAGYDGQVKLWETRSPRTPLYDLSGHEDKVLCCDWSNPSLLVSGSCDNTLRIFKAKHYQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5R7</accession>
    <name>A0A835L5R7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000003">
        <property type="entry name" value="Polymerase (DNA directed) iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="601" mass="67278" checksum="4C9B00468A639778" modified="2021-09-29" version="1">MESGCSHYNDVDSEHARCIIHIDVDCFYAQVEMVLNPELRSVPLGIQQKNIVVTSNYEARKYGVQKCMLVTEALKLCPNLKLVNGEDLHNYRTASNKIFAVLQCWKCPVEKLGMDENYIDVTNLVQEKMKSVNSSNVSHAGHVYSEPSIDCPCGCHTRLRITSQIASDMRKKIFDDLGFTTCAGIAHNKLLAKLICPQNKPNDQTIIFPEHGTSFMSTLQSIRSIPSIGSKTAEALISNNIITVSDLQEASLDMLKKHFSSDMAVRLKSLSIGEDNTPVKQTGKPQSIGLEDSFKIVSVRSEVEDKFTALLQRLLVLVREDGRIPVSLRVTLRKKDAKRLSSHRESRQSQISPSIFTLTSGTLTVTEAGQQKLMNIIMRLFNKLIDLTKPFHLTLVGLAFTKFQERMTGRGSIVNYLMNDISVQSVLNLQNECDTSATSMDYSAVSPSSSTTTDLSDAEVEPSPKKPKKVTWIAKRRCLAKEEVASPSKLKVGELRLNSKELEKVSELRLNSRDRSLTPRASPAKDNLSDTSDTMRDCEEKNCDDCPSYVDKEVFNALPNNMQKELKSMWKNPSSSEMPRSSPRTNKAKPNTIMKYFVPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L732</accession>
    <name>A0A835L732_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L732"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="96"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9416996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="304" mass="34942" checksum="8B43F0A768AF4612" modified="2021-09-29" version="1">MKFFKVKFFEVLDLVKMRKVYLSGGYAYIPHKDFISVLSAQYRTQLKQSLAVACHHLGEIEQDERLVSLLKGLHQSYSGNDYSDAKAVIPIETLDSLAVKSFPLCMRQLHDQLRAAHHLKHGGRLQYGLFLKGIGVTLEDSLRFWREEFTKIMELDKFEKQYAYNVRYNYGKEGSKRNYSPFSCLKIINNTVGPGDCHGCPYRHCDVGILKNRLQGYGFDAQAIGEIIDMTKKGHFQIACSKYFDAVHHCDVGLGINHPNQYFEESQKIAKGEIKVEIKKEVQKAQLKKEPIDELDEMDFDEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L786</accession>
    <name>A0A835L786_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L786"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="86"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="290" mass="33676" checksum="C9A1598F31560C26" modified="2021-09-29" version="1">MPPENSKTKFTRGEKCLFIHLIVTFSLLLLMIIIYFVHLCLVNHTKSDALKIYRRSYDKSLTDLPLSDYQSVGVMFLNTTPPIVVCNTLLLGKRWSLAPAQCTSMRDDPNMLDHLRQWKLKYKFDGKQTNTDVKRTLTHSQFSRGDYQNNIGLFEHVDPIERSSYYVAPKNFFIDDKTLQKYFEQMSIIDWDVHFSEKGDTSDSITNPVIPILSDKCEMYANTIVGKIRNYEFCVTFKNNSGLADHGAMFVMNAKIIGFFSWGDRRGKGMPLIILNILPFREWFESIIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7C8</accession>
    <name>A0A835L7C8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7C8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="79" mass="8353" checksum="D983F77581C6E480" modified="2021-09-29" version="1">MTDACQGDSGGPLLYGDVVVGVTSWGAGCALADYPGVYARVSSYTTWINNTINRFNGASSVSGIRITLLIPFFYIILIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L859</accession>
    <name>A0A835L859_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L859"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="146"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="423" mass="48236" checksum="CEADDD0EFAA0D365" modified="2021-09-29" version="1">MTATAGTDITSISTMVRLTLASVSKHLTEDVIDKVFKLKTNSEDSVQSIEVMRAAPAGEGLISAVYRIQVTGKNHTAKFIAKGLVHDPLMRKSLECHTYFKREALFFSTILPILCETQKASGAKERIQTNLPKCFGCHLDGKDDYILMEDLSEIECTSLPENATIYERNLVLKCLAHFHAVSFALRLKKPDTFAKLANRLNEVFYNDNNKSWYASYLQDGIDIDRKVIAEFEDPDSIYYKRFNALFDEDIYGQLIRIVNSRGDHPVFNHGDAWCPNFLCNKDKAVAIDFQLLRCTSPAADLSYFILMYQCRSKEEFMEAVEVYYKAMEYYLTDMGIDPSKAFPFETLLEELKKYGSYGMLASLTSFPLLANERCDTHQSFEIKDCGFDRIPLVELWPLTPIKHEQHKMRLVHAVRVAVDVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9T5</accession>
    <name>A0A835L9T5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="571" mass="65270" checksum="09BBC3DD9DC81A19" modified="2021-09-29" version="1">MRYNTEKEHCFGMLRMTSFKAVSSVETIVELTGSLTKSQNPNKVVAISRYLPIKFKTGSLLNESGLGKGLSSLDRLGFGEIHSFLRGVGTLYWMVINRGVGTLYWMVINREVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVINREVGTLYWMVINRGVGTLYWMVINREVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVIKRGVGTLCWMVINREVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVINREVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVIKRGVGTLCWMMVINRGVGTLYWMVINRGVGTLYWMVINRGVGTLYWMVIKRGVGTLYWMVIDRGVGNLYWMVINRGVGTLYWMVINRGVGTLYWMTEILQNVVRHCVDYVLVVQCHYERFDFQDLYFPLRPFSVNAYKHPCLFAVLAHEAAYLSLSLQSSLKPPHYVGTWVLVTKLRSPLAQKSQSVVSYKMNVPEAYFAIYDPFLVLAVPTASPVLYIPGLTPGSATGTVMSCGVACNVPLLSRARMYCTPPSPMTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9Y4</accession>
    <name>A0A835L9Y4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STING ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9Y4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061507">
        <property type="term" value="F:2',3'-cyclic GMP-AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12100">
        <property type="entry name" value="Stimulator of interferon genes protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029158">
        <property type="entry name" value="STING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038623">
        <property type="entry name" value="STING_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055432">
        <property type="entry name" value="STING_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339:SF1">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15009">
        <property type="entry name" value="STING_LBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="STING ligand-binding" evidence="2">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="STING ligand-binding" evidence="2">
        <location>
            <begin position="196"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="STING ligand-binding" evidence="2">
        <location>
            <begin position="424"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="629" mass="72095" checksum="607313A39EF94374" modified="2021-09-29" version="1">MFSIVRYVVYDLTIKCTKNLSTMGYDILHKKRRLNMQLVQNINAGQIIMFISSIAVLISNNEKIFSEDFLLLFIAYLTIQYSILGTTPLSSISYGVGMACNFYEGYLMHVIPSDGGNYGGFIQNVQAFEAREGIVVPVRKLFIVITKSMYSPPDLQMFNKENRSDISKLESCSVRIGDYSKGPLPSFAAIDDAVMFQSLEDRSRDVGGIKNRSYKNTAYKIHRQRGPPVYLVAECATPLYTLYRVMENKELYDDLAKVNIQDVCEDFCSTLMRLLDRSSECRDKVELVYYDDKDPEANLADVLLNRIQQLEPKLEELIRSLDFSNKQTLAINIARFVLYVLSVQGFCEACAVLYNCVCHQRLPEVKLLRRVHRHHVMMFLGAVVLLLTYEQPIIDERFFFILIATLIAKFPEIERKLDEKKTVNYGIGMACSYFEGYLIHVLPSDGSKFFGFLENIKIYESREGVVFPVKKLFVVVTKSLFSPPALEEFNKTGRDDLPKLEACSSLSEIEKDVAGIKNRIYRSTAYKIYRPNARPVCICTEGGTPLNTLHRVLKNSELSEELAGINREEIVLDFLTTLRKLIAKSPECRDKCEIVYFDDSNRDLNLADLLLDRIRELEPNFEEIIARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAQ7</accession>
    <name>A0A835LAQ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin glycylase 3A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAQ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000032">
        <property type="entry name" value="tubulin monoglycylase TTLL3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="98589" checksum="DA033CD467033A52" modified="2021-09-29" version="1">MAVTMELEESASDSKLHRDSTAKKELRPSSAVSFSKSEHGPECSSSNEQLKQYKSWVSTERWNELKKIADNAMREHKVFMIKGGGFPAVRRALLERGWIEKYESHKVLPNLPAVRHPPHVDPKKLHGKELSKVERMILYKFMEHHSVDFLWTTKRDKYDWLLSNKDVIISRFCRSVFTTKEGLTTSLTQMHWHTEPGVALTKFPRCYNIHNSDSLEEFIDDFRITACISVLKWLSIALQNNAEESLVTTNGKVPFSAIEFAISRLNEYIVFLTHKDIDDTDDQQHVWEHEWDQFLTHHYLLVHEKAKFMEDKNANVRQLERKGSKILATMAKYWPQIDIDGILNIWIVKPGNKCRGRGIQLMNNIKDIIGLINIPAQKTRYVVQKYIENPLVIYNTKFDIRQWFLITNCQPLTIWIYKDSYLRFSSQIFSLSNYHESVHLTNNAVQTKYKNTGERDKALPDENMWDCHTFKAYLRQIGKYELWEEKIYPGIKQSLIGAMLASQETMDKRQNSFELYGADFMLTEDFTPWLIEINSSPDLAPTTSVTARLCPQCLEDVIKVVLDRRYNLDADTGTFELAYRQVIPKAPAYLGLSLCINGKRVLKKCKERKHEIKSAHTPVPPRVPSGDAILSSDQDQPVPPEYSGPIITDFLTWLNPYDALPTNKDGIVLGPKDSLTVRQAITVVKSTITLKSAPKKRKSSLSFRIHRGRRERNTECKRRIVPHSCCRPEDGQFTNQTSKYRTESASKAEKTKVDRSVGNKRCYIDPVEWERETASILRSTISVQNKVVSKPEPATSLRHAKSSVVSSNRKSVDTINRRNSLDDSDPIKKLSAIGTNTISMDPFPTKSLLPSHAIDTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCK5</accession>
    <name>A0A835LCK5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1759"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1180"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1789" mass="201110" checksum="6A6C2931E5A16DEC" modified="2021-09-29" version="1">MRRGHPGIGGWRSENQRHFRPRGNGPHDLELLGTILYLKTPDSRHPTHVLAKEARILTQPMEDIQRTMVDKNTMKDINTEMAITKLIKERQTESSINGQDKPEACHVNSMGDIDHRLPPHGQQDTFNQSRIPQWTNPPPEYKKRTYEDRNQKPYRHDFSERNKVPVVDYTDYTGHRPPASDHYGSTSGPVSSTNNTSFSRSVDDTVDIIRKRLMNRNDPQTSQDESAPQGNTEQVVSENVIPQVQPEQTPKRRTPRQKPNVKSNCDKMKSHIVHQLFKMDKDKMHKLMDDPGSSSKFEYAISSLITESQNSLNRHLRSVAEKSLYSSSSEFIQNDKNTIYEDTFMKQMQCLLDPQDTVLLEDIKPIVMAELSKVLQISDFDQRYDTPEEQIPQQTADDQSNYLYGDNYNYDEYTQDRCYDQSQTSSINYDNLNRVDIVDGSSVNYDYNPQYEDVKPLFERRPSKRIDSIEDRRQSIENQRKNLRKSLENPVEEPFKGKEEPMPLFNSSDPISEDEDTFAELDRQYHVAVDHNFIENDDLSSKDTPTNFLPVQNETPQVNNEIQNQLQTIAQAPINLFPVSSTESFRDLAIKIKQEVTSCESRDENTPSRAQPAPKTPESSVHKMNMKIKQEHVPQAKDTDKETEKAGSSHTIKTPPSSSRKRSTDQKPSHRKEKRKKSNSSQPEPTKTDKPSSCSIPSTSSTSSKSTEKCNDAPKPYFSIFTNKDESSKESKDSKKADAADKIYSDKYVKRKEHPKKQKEKGSESSRKRHSSTSSQTILSPKDNQTPTKPDSSKNKLKTFDMFVEQPKKTVTIHQAHRNTATAVTPTKAPEDVLKVGTSTPARHKTPQTKHAGTQVIRRLIAKETQTNQIKSTGVHATKFTQTDRKKFVAKHVQTDPIIIKHAQDEAGGTSTALSNPEDVIDRMKEIDLEIQILLQEKFKLYSSLENKDACSSSMPTLGMTVLNVTTNDNDENKECDENDALSDNLINADSIVDDFTNIPVEELEQIAMETVQEDSSDSTKVGKRNLRPKVHQQERKHSESPTTSMTRRSQKTKTPNISLIEQIITDDRPLEDIISLDDLEEPQAKNKKKSQRPQPQSKKKMTRRTTNTKPLKYLNTSAFDLKDCSVVLIQTDVTKFIKEGSQIYLHSESSQNSHHSQSSQHSEHSESPPRSQATYSCEPSLHSQPPDQPQHLQQIQQSDEDSRCSDPSASPDLVEVYSIEETLDKAPTSQLEETVVNDLQFDMLDVSEDIVIGDNCEVKCIEDKDMERGTISEDVILDNSQSSADEAVAASMGHVENECRTYDYSTDEQLRRDSITVTGNADAVLAVECIENDFIAACLDGNVYHFSGDGHLLNTLRGSNLAVTCITIVKEKGGTTVYTGSLDSRIRYYDLETGLEKGPECNVLSPIQTMDRAWDTVFVGTRTGFVLQFECKVSISIESEHLEQKLLHPGAPCHEGGPRKVLLVASRSEDVTIKDAQSGLLLRTLSGPKMTVYTLLFEDGKVYCGTSSHQIHVFDYASGSHTGCHEGGKGAVCLRATGGLLFAGCYDGCVYVYREGETRPLAQLRGPSLMLLSLAIVGSKIIAGYKDRSFDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTVDLDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDCTDQDSFSNVKQWLEEIDRYACDNVNKLLVGNKCDLTTKKVVDYTTANQYAEQLGIPFLETSAKNSTNVEQAFMTMAAEIKTRVGPPSTGAAPVGGQVKIDQGHPIDTGKSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCY1</accession>
    <name>A0A835LCY1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_017945</name>
        <name evidence="1" type="ORF">HW555_003800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9627970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCY1"/>
    <dbReference type="OrthoDB" id="6624851at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9627970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="219" mass="24548" checksum="B5B6EC5C1E8E4C1B" modified="2021-09-29" version="1">MATNVAVPPPPKAKKPYEEISAIFNGNEVKIRVPKSTSKPPKLTPSQLKLQQSCTCEDDESVCSETCGMVRDGDDQCPGHRLDFQVPDDICESLTHRTNLNSELVYSKHHGNDTMCNICNVTPKDAPKGVQAQKVLHPDKDVFILKIGKQTDEPNRTGNIEVELVTPRAPAKPQPKTHHCMQIQCEEEDMPCCLPCRMCRGGMIMPRKRKLKRPRCCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFF9</accession>
    <name>A0A835LFF9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_008062</name>
        <name evidence="10" type="ORF">HW555_001454</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000297">
        <property type="protein sequence ID" value="KAH9639967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFF9"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="114"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="328"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9639967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="493" mass="55377" checksum="83ECF25D7AC41794" modified="2021-09-29" version="1">MSKLRPILNLSYCRYYSVKQAKKKLPIITCKRPEFNHYEGQSYSKFEGIPLASKGWMSKKSKNDYFIIYGNANKKEEKPVYKKSFEEIGVSPALIEVMSEQGFSLPTAIQTKAIPSILSGANTVVTAETGCGKTLAYLLPIFQHILEWKPSIKEEFNSPLAVVITPSRELATQVGEVAQNMAQRLNLNVTTLVGGRTKQKMLNPPIEYCDILVTTLGAYSKLVTTGIFKINNVHHLVLDEADTLLDDSFIDKVSHLLKKFPIQQKVQIQTPPVGCQITLVSATMPHELPTAVNSFVDPESLKTVTTSNIHRILPHVPHKFIRLGKAQKPIELLRLVQADMNQNRPVMIFSNQTSTCDFVSMFLNENNIECVNINGKMAVALKMGKFELYKSGKVNALSCTDIASRGLDTLRTQHIINYDFPLYTADYIHRCGRTGRIGSPKDCLITNFVAWPREIEQVQKIELSVRKHSELPSVNANIRRIIEDRVIKMAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>D9IPD1</accession>
    <name>D9IPD1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gallerimycin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007005</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2010-04" db="EMBL/GenBank/DDBJ databases">
            <title>Antifungal activity of gallerimycin encoded in the beet armyworm, Spodoptera exigua.</title>
            <authorList>
                <person name="Park J.A."/>
                <person name="Kim Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM161723">
        <property type="protein sequence ID" value="ADJ95798.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D9IPD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036280690" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADJ95798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="75" mass="8262" checksum="7EAB9533F2064588" modified="2010-10-05" version="1">MKACVVLALLLVAFAVATSDADLGHTEASYIAKRETIRGPEFPNRCVFYECSASCRRRGYRSGGYCTFNGCQCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G059</accession>
    <name>A0A835G059_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000893">
        <property type="protein sequence ID" value="KAF9404751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G059"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="140"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="504" mass="57416" checksum="E05F2C7086F25E40" modified="2021-09-29" version="1">MAAKQQAVRVTRNLKLTRSHKILALVPEKNACSEGSSSSDEETNVYIPPSPDTSDPPSLASSLEGLNLLDSSTESNKEQIDISVDAPLTPIFNEVFPSPTTSNYNILPTLNSIQSLPTPTVEQSSPQPGTSRQQLPLTRSKHRYFKIRPVMERIRQNFLKVEEEGKYSIDEMMIPYKGRKAGKRKQYVKMKPKKWGFKNFVRAGVSGIIYDFLLYGGDDTFRGLTFRDKEASIGLGGKVVIALCQTIRQKPAIIYADNFFMSLELTHILREEYGILSLGTIRTNRLRGCQELLPTDQQMKKKKRGSSAQVVCNKNKLAVVKWNDNKVVTLISSYIDSHPIETIKRYDKDEKKKVHVECPQIVKHYNKHMGGVDLADMLISLYRTPFKSHRWYLGIFSQLIDMCINNAWLLHKRDGKNIMLKDFRFQLFEGLTKSNKIVKGINATEDIGEDLKIHKPVSVRPTDSVRFDDKGHLPEAGDETMRCKYCKSGRTTIWHVFIDFDYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1H1</accession>
    <name>A0A835G1H1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylinositol-4-phosphate 3-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_013466</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000653">
        <property type="protein sequence ID" value="KAF9406002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04012">
        <property type="entry name" value="C2A_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08381">
        <property type="entry name" value="C2B_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1388"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1688"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="13">
        <location>
            <begin position="465"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="14">
        <location>
            <begin position="732"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="12">
        <location>
            <begin position="925"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="1323"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1560"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1543"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1543"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9406002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1760" mass="197480" checksum="E0DCBE8E2A10AF78" modified="2021-09-29" version="1" fragment="single">IHIEGSPIMSDYDLQFQADLEKAQALSLESLALDQFRRQKLLSTGTSPTRDETSDLISFSSPTSKHAPKEPHVKLKEYIDQITKLSQQTEELALNTSEQSGTMNNQHYNQRPGYYAPQYAYNYQPPYAPIPPYPTTPYGMPTPMPTPMPGPIPGAMPAPMPTPYPYYAPPPMANPSDMPPTFVHVNPMYSAPYTQTRMASPSPYAYPVPSAYNYSTTNMISRPPRPATIYPQLNQTHTYPPVPKNPVNNPVNNPANNNASVNNNNSVNQSPTPARTEPVKEKVENNSSRKASEASIASNETSDTLGSLPQSMNLIDFGRNTAQGSVRVSVLEAFDPLLTEKNITEHAAVSSECSSSVYEEYDPLDFLYGETEMRDAVYATINKKDPMLPSPPPKSIPSVPAVAMRSTTNKLYDCIVKSRTKNYDNEHKSFLKMVLDVRKRFVYSDEKTNPGYVIAARSGGKYPPNTSIKILVHHAHSDEPITFTSDVESTVEHVILTVVCSLDEDIREDMSEYMLRVRGAKEYLTPGSSLSEYDYIRECVRLEKDVSLCLAEGRDNVLARTERDDARDSHLTLDDLLPCHGTTAQLSFDNLSILLETLEGELSRAVGVTGAEGCCSPKAVFQAVKAICALAGGVETLHVTHTLNAFAQACTSQNLKNGVTPEIEADKGPYCSVSLRGATRREVVAAQCARVRDAVRALLALYGRTRLLDFHLTDTQYLTPNNTAKAVPAHTISEATLFCIEAVHCLPLCWNHDDYLFQAQIFYGTRPLKSLHVTQPSRIECGGFYPRIIFDTWLNLEDVPVNTLPRESRLVMTLYGRSQRTVDGHDSQAQDSEEIDMNIQYDLVELGWAAIQMFDFDGMLASGNYVLPLWPTYCDRRIGPAPHPMHSPTGTFPVVNIEIPLYAHNGVKWTNGEEGRQRKLKQEDLPKFDSLDGHTQSQLLALIEQGAYQRMPSECREIMWEKRQYLVQLAGALPLVLMAATNWYGEHREHLIALLNLWEKPSPLNAMHLLLPCFPDHAVRETATRLINEMSDDDLCRVMPQLVQALRHETYEASPVAELLLSRALSAPAVAHRLFWLLVHSLPNVPQAPNQEFLGISLEEGAQESAESDAGTAATWRYRLLLRALLATAGQSLHTTLLRQQLLVKTLSEVAQGVKDAKETGRARALTSGGERLAALLRAQPAALPLALHKYVHDVDVKSCMYFASNTLPLKINFIGNDNAVIPAMFKVGDDLRQDALVLQVIKVMDSLWLKAGLDLRMVTFQALPTSDKRGMIEIVSEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTDFGKFLGDAQMFGNFKRDRAPFVLTHDMVYVINGGERPTQRFQHFVELCCMAFNVVRAHHDHILDLFALMAMSGVSGVTSAAVGFTPINFFLHNLAQLRASGDQSSNTSELLSFMPRTYTMAQEGRLISVECLGYEKRYDPEKHYVYALRIFRQGQTTPFVLYRSLPSGLYVGRSNTRQVAERRFGDVQAFLTSLFSLADEIAHSDLVYTFFHPLLRDQQDVEPQRRRGETTEPENSGSGSLKLSVQYASGVLSVLILHAQSLALTPQGLPPNPYVKVYLVPDPTKETKRKTRVLKRNSHPSFMEMLEYRLPMEVVVQRSLQATVWNYDSLQENQFLGGVVIPLNTLPLRQETVAWYPLEYIPRKYIFLLRVLLILISMNSWLNRLLIIKLYNTFNSLSNNYILRLPVLHFIKLQYYSTVFYVALKGITKLIINFIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1K7</accession>
    <name>A0A835G1K7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000639">
        <property type="protein sequence ID" value="KAF9406106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1K7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="75111" checksum="F6740F4D5D1F6CC1" modified="2021-09-29" version="1">MAVKFSGISNGPIIFPQRIPVYMFTLNRYWDLSSRIKCGFSTCHSCKLCRILCAVLFGIPVSASIPRTEMLGFADTASKTSSRMNLRLRFHQRCARMRSEGCVCKEPIESLHLPRLGQHSSGGNGSAELDFCAYKTSEECVRGMCTRDVCEGCVEKDVLRGLRILYQPVHRRSLLEVEVREIDMDNWKKKILLYLTICDEEMEAEDTEFISSIILNNRRTHRSNFYELHNLIENIIKKEDTHYRECISTKEKLAYNIICKISRQQVPLLHGKLGSVFLVPGDAGCTASSWKDESIWPAILFVFLVPGDAGCTASSWKDESIWPAILFVFLVPGDAGCTASSWKDESIWPAILFVFLVPGDAGCTASSWKDESIWPAILFVFLVPGDAGCTASSWKDKSIWPAVLFSLKNNQVVQDPAEAANPSGLLYYLRWYQSLKNNQYFDYTTTAYRKKSVMSPEEVVLLCGAYIFLHKSISSKKKRKRWWVRNYLLRRQDVLSDLCMFDGSFINFLRMSKSDFEYLLQNVGPFIEKQDTNLRSAVTAETRLAITLRYLATGDSYSSLSYTFRVSKQLISRIIPEVCKNIIRVLKNYIQTFDFEDSDHNVIEGAWRREYTVEGTSILELERRPRNSARTATIIRDQFGEYFMSERGSLPWQNNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1N9</accession>
    <name>A0A835G1N9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000650">
        <property type="protein sequence ID" value="KAF9406027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1N9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="452" mass="52899" checksum="6DC8916FB381244F" modified="2021-09-29" version="1" fragment="single">RRGGKTLLRAGHKYIKRRENKNSSTWHCVNRRNSIKCSGYITIENTNNTIIKDYKHRDQCVPHFEDNEVQMAISECKKEVNSNYGSVQKIFEKHMGNLEDKRLHLTGNVPDYKKLKTVLYRHRNKSLNVPKTQFKNVEEIIILEEFNKYVLADYCNEDCNRIIIFSSTEVKEHIKCVTHYFGDGTFDGCPNPFEQVYVIHRDMGSTELSTNVAPLFYILLKNKEGKTYEKVFELIKQTLPEWRPSKFTFDYEIGVINAAANIFPDIKINGCNVHFQKNVIKKAKSLNLMEHEESSNHVKQCIGLAFLPKQDIEDGWLHIMENSFDDEAMTKFNDYFVTQWLEYPDLIWFCHNERHRTTNLAESWNGRVNKIIGKNPSLLLFLQTIGNDTCHFDIKQANFRLKISPINSRKRTSIEIDRQIQKLTKSYENKAISIGVFLINISKSIFRSEHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G209</accession>
    <name>A0A835G209_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FP protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_013263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000608">
        <property type="protein sequence ID" value="KAF9406328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G209"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008527">
        <property type="term" value="F:taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050916">
        <property type="term" value="P:sensory perception of sweet taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004941">
        <property type="entry name" value="FP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009318">
        <property type="entry name" value="Gustatory_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03258">
        <property type="entry name" value="Baculo_FP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06151">
        <property type="entry name" value="Trehalose_recp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="FP protein N-terminal" evidence="10">
        <location>
            <begin position="180"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9406328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="659" mass="75350" checksum="691FA30A3C511643" modified="2021-09-29" version="1">MVLSKCAVCKKNITKKAPGLECSRCNKTVHADSACAKLSNKQLNILRNSTGIEWSCEDCMLNLSRRSSFLVPDDEGEEDSDSDHVVNAKATFDPRKLAQDISRELKKTFREEISGLQSSLQFLSEQIDSMEKSVKHQDTRIKELENKNKDLHNKNKNLELRVAVLEQDIKQIEQNTLSLTLEVAGLPEISPPDVPGVLATVGTKLELDVQDIQFSYRIPGNKGKPCTIVAEMKSKNARNQWIAASKKKNLTVGQIFQDVAEDRAHKRIYVREALSKHFKTLLYNTKQQLHESFQFTFRSPYTVFYAISLFGQVLMFIMNFCWVVLNGISLANMTNSIFNTSSLVSVLILMHIGRSWPTLVAKVEALECKLPPFTRNVGAMMEHLLSIYYGLKVACACDINNVGESYFRFSMPWIFDYTPYAAWKGALIEIFNIQSTFVWSYNDLLIMIISIYLTEHLLVHNELLKKAVEQEHFPCQVFRSQYLKIVHLVRLINGQFGIYILTSFGSNLYWICTQLFYSLSRTQTGHFIACTFKEPEGANAEHVFDNHPICSWMLDDRRALNGLEHSIYFTYSFSFLLVRTLMVLLLAARIHSNSIAPLYVLYGIPSSRFHVEVERFIAQINNLKVAMSGLDFFYVTRTMILTLLGTIVTYELVLLQFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3B7</accession>
    <name>A0A835G3B7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000656">
        <property type="protein sequence ID" value="KAF9405963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119832" checksum="8AD8A1D13147A866" modified="2021-09-29" version="1" fragment="single">MRPRNTRARRYSETNVQCRDTVARDGSCAENEDHFKPTPIPLSDWPSDKQDVAGTLQEIIKTEAPQTAVPAHYWEDALRHSVYLTLVRDKIDQLIAQGDYISPTNKPENQMAKEIDDHDLWEKIKTARFERLKEEPIPSSDVALLSKGRLVEDQDGYKFIEDNVLWKNCSDSDCSKDVKAYWSVKRMRQTDGRSGKYSYELTFSVTSQTNKKVKKPYENPVRTFTIKENAPTERPQARHQEMGSHRYVGRPQRAIWVHRNINPALRRPQAYGRGLDRLFSSLFSDEDSYEDAPLFRHKAKTQKTYMPNVYPQHSKVGFLDDRDPYHQKKLPYPVPYRLGHAPVPPPPVSYMQHPYTDTGVNFPYVPPQTDNRFVPSNIVKTTRPAVLPTPITNHPLQKEPTIEFPVKTKFNATEYTTKVPDVATTYKIYSNPKPSPVKISYVTDHIRPPVYNAPPGVFVTMDKKPFKPMPPLKYNHSNKPQKHTLPDFRPSPQVLDTQFSELDLSADSAFRPINMNYTRIKDHDNGKKNDKNVFKSNAAKKPPKKHEHIKPGRLTTVSPDIITAQSMTMEDTSLEWANILGAFTKTTPMASQREKGTKENSEAITTTTPLSTTLTEESTEANDNSVEEVSPTTTTTTTTTTTTTPAPKPKKRTRPPPKFNKQEKTKKHKRITTTTTTTTTTTTATPTRTFPTKKPSDDLTPQASSAATSGANSIRDIKTHKAQSTTSTSSPTTTSTAPRTTTTVKLTSASVTTTSTTTASSTAVDTEQPVATTQPKSKNRFRQSTLMHKGTSVNHDKWSASTSFDKNRTNQSFLQNPARRKASKFQGYIPASTAKTPDFDKKKDDHKDYGFVNPKNLTEISSTTEQTEQDIEVKTKPTFTYEDQEYAHHAVDDSDNYTEQRELKDETEYIFSTTSMTKETKSDVGYQSTTTELTSVASPYSVSKNKTKCKKKKHNNLTTEALKSSSETVVTNSSEKLTMSTTPKSTEKTTTEDVLNELFGGFTMDDVTETSTTERLTTTQEEQKQSQSENHEQYVHLDDDLEEFLYSLEEKPRDITNSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4J0</accession>
    <name>A0A835G4J0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000590">
        <property type="protein sequence ID" value="KAF9406447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="68" mass="7509" checksum="9E6AABA61BC7E4C8" modified="2021-09-29" version="1">MGPVLDALSVTTLKLTCGHCNVMKRESKGCAAIQDEACETPQLLLERLKPKHMVIQQPSGCWHPVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4W3</accession>
    <name>A0A835G4W3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4W3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000004">
        <property type="entry name" value="RNA-binding motif protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="6">
        <location>
            <begin position="682"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="552"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="88318" checksum="CA500DF6F37E9E73" modified="2021-09-29" version="1">MSFPPRPPLVPYGIAPGVVTMQMPTHVMVGAYSASNAGSGRGALLPAPPPGKAVISRGPTRNANGAKDPEGPAVTVFIGNISSRAPDAMIRSLLGACGPVLSWKRVSTFGFSEFASPEAALRCVRLLNSRPVADKQLLAKTDGKMQALVDTYKTEQRSRLGQEEGAPGTEGEASYLDARQRALDEAAERRLQQIMRDYQDDINNYELLQKEEAISKTARVLEEADISEEKRDVIHREIGKFRESMKEEADVVVRRKRDNKDEPDRPRERDERRERDDRRDRPADRERERDKDRERDRERDRDKERDRDARDKDRRRRSTSRSRERSRGRSRSEADARKDKEQEDEAREKKRLEKKAREKEAAYQESRERRKAKEYEKERERERCREEEREKEAKRLKEFLEDYDDERDDHKYYKGKELQRRLGVRVREAEGDARERTREAEELEELRARVWGARAPDDPAARAAFDRARAALDAQYRPRLLIDARLRAARERERYLRLAASPSWEEEGGRRGLSNLHTKNDGVHSCMSVWRCKNADSFADHKVIRNRTVTSTGSSPITISFKNHHKLSPSANDTPNESGRVRRVHAAFAGDDDEPTGGSHGGPHGGHPPPHGGSHPPSHGTPTSGSHTHDQPRPKEKKDKSKKASGGGANAEAAAGDKENRSAEEKRKHIKSLIDKIPTQKDQLFQYKLDTAQIDNVLMEKKIRPWINKKIIEYIGEPEPTLVDFICSKVVAGSAPQGILDDVQMVLDEEAEVFVVKMWRLLIYELEAKRAGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G588</accession>
    <name>A0A835G588_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000449">
        <property type="protein sequence ID" value="KAF9407647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="750"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1407" mass="161378" checksum="80267114AA80873C" modified="2021-09-29" version="1" fragment="single">MAYLLMWDVRELVPVPVRVEPPSQLSVLITADKGYVSQAALHHQDLRLTGVSADHQGFVSSYQDQSTIQKLAINIKKDSPDRKTSDYFKRRLDTLNQYWSDYQYNHDRLLSEESRTHPYFIGRTYEKAKELYISTKALINQQHQGLLMKIKEAQQEGSTQEEQEVMSRQSPPVEVCSRGSSSKLDELLKKQASNFRALQRTVAGINLDVMSEKWELKDALRILQARWSIIDSLHWELDSELEGTNQEYEVSYTKQETIYNELKNAINKKLGSVVHKENWTPKIDIPFFNGNYQNWVSFKDLFIEAIHSNVSLSNAHKMQFLKSKVRGEAERLIQHLQISSDNYNVCWEILNNRYNNKWLIFTSHLDLVLNLPVMQQANALQIKKIHDTTLECLNSIRNLGVNIDSWDPFIVRILLLKLDADTHDHYLESLKKPRELPNLNEFLSFLESRFTALESSRKKNENSKPSTSKQNKSSSSYFKNKYSASKTSVNNFEVTCPLCKESHGIYYCNRFLNMTPNSKRQAITRLNLCKNCLYSHGDKECMSEKRCRECNGKHNTLLHQAFNNKSSCNTITENQVPAVLATQNQESQENHVSQQGNNVIETLLATAMIKVQASDGSYHKMRALIDQGSQASLITARATQQLALSRKYCKAVICGIGEKESNSKGVTNITCCSHFNDFTFKTDVVIMDTLIILNQVDELQRFWENEDISESSNLSAEDLQCIEFYKNTTTRHENGMYEVRLPFQENFETHQAHELTFHGGARVTSAFIRKNYWIIGGNRAVKKRIRTCITCRKHSPSKMTQLMAYGSYNVTQLKDNQGFYLDKIANMQLIRDDWKIVTYYDMKPFWQGTEACSKYLSYLEQLCNKFKETSHCDVIQVQLKQEFSELEYYNHLLLKYNILKRNGQAINKQHKMLNTLSIKLDKIENVLLNESERNRIMNDFSTSAIATSNVLRQLKTIQTSLLDTVTDVYHGRLNIHLLSPEQLKDTLNTISSHLSKDLTLPINNLQINFKNIYHLLTVKARMTEEFLIFELKLPLVSRDTFSIMKIIPIPQPVGNSSMVTLTPIAEHVAINLKKDSYLPMSLNDVQTCLRDDVDNYLCHIEKPIYHLKNNEKLCKVEPDSSKCKISITTCSNQWTALSKINNYAFFCCNQCEIRVLCDDNVSPGQLIKAGILGVEHDCLIKTESFTVYSRNEGFSTLDIKPSLKLPEIEPINHIINAGISTPLIENNTLLSSNEELDEIKKQLRILKASEKLPNQISYHDIHHYTAFYVMIGVVMVIGAGFMIRRLHHRRSASLEVARVAMASLQATQHVTSERAEAGASPSSSTVEYSVSARNQHDIPCVSDYSEISKVHKLDKCTVPMSLRVEPPSQLSVLITADKGYMNEYAEKKRINKLVGTIPFKVLILQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G740</accession>
    <name>A0A835G740_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G740"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033028604" description="Envelope protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58454" checksum="BD05A28ECD3C18EB" modified="2021-09-29" version="1">MMLLIAFTTLSSGRAAPLQHFKITPLTENQPVYFDPVGNMQLIHDEWKLLVYYNLTTFWQSTTRVEEFVNHLGQLCDTMPNEPCHSTLQQLKFEMNQLKEFQIMKTMNDVNAGALTASLLISVLRRNQEMLLSALTDIYRGHLDMKLLPPEQLSQQLNYIAGIIPKRLTLPIRDTNNSNIKNIYKIIYVKARLTEQYLLFELHIPLLSDDEYTLYRNIAIPRWETAAQCQVIQTVTQYIGVNFVKSTYIQMEEVDLQQCTTMSADNHICHASTTINNLHGATASCEAKILNQNVNNVTCDWVSQQCADQWIKLQRPNIWLYNCINECTIRIVCENRITTTSVTKAGLLALGQDCILQHKDNTIYSHNVFSSSTNIRINLEVPTIDSPNDMWSTLRNTKIVLPKLNLSNDHKLLDDQITAQKGRESLPDGLSVHDIGNYAISSVLVGGIVAAIIVWRIRRYLQARKQSATVANKAQERTEDIELKEMPAYAKLRGGRSENNRSQLPAIGTRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7F7</accession>
    <name>A0A835G7F7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000248">
        <property type="protein sequence ID" value="KAF9410748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7F7"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="59"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="310" mass="34992" checksum="19D149428C8FEA5D" modified="2021-09-29" version="1">MPLDYRRFNGPEDSIPYKRFTKDFVKSYDELFKELLDDKGVRKDGRALSEARSMCMFFARADMVSQAKGSAYVELRKTKVVCSVFDPREIPHQNEFSELGQIFCEVKFAPFSCPRRRRPHAPDAEEKALSVALRKALEPSVCRHMFPNYQVDVFIYILENDGACLSAAINAAGLALADAAVPMYDIITSCTVAVIGDKMFVDPTEAEEYLATTNPDTPINHGLLTLSTLSELKQISDFIQIGSMDVLSVTNAMEVLEKECERLVPLVQKVLVGNVLKCFDQRKRLEEEANEREKALNSKMEEWKKLLNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7Q2</accession>
    <name>A0A835G7Q2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007747</name>
        <name evidence="3" type="ORF">HW555_012079</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7Q2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63578" checksum="5DF54E6278301381" modified="2021-09-29" version="1">MTTYWKGLSDIKSYVNHIKTMCITHSSKQYQSIIVQLEQEISEIEHYDMLLKNTNEAPMRLRRGLVNGVGYIANSLFGVLDERFAEKYKSDIEQISHNEKHLQNLIKNQTSIMESEFNILRRNENVMNKQFSFINQRLQDLAREVYEVRLVNQDNNYITSSSLAASIILSNLRWIQQTLIGTVTDISHGRIDSHLLSPEQLSYQLSIISSQLNGKLTIPVDIKNIKDLYRLLKVSARVISNYLIIEIKIPLLSNEMFELNKIISISQKQGQHYYQFLTSVSFIAYNLHKDTAFLLSEEDLKSCTHIPSDILLCSLNMPIYDLKMKQSICDIKIINHAHLCKSVKSSCEERWIKLHRPNTWLYTCCPECQVRIICANGVTMTHLINNGIITLGQGCTLKGDTFSIYAHNNFFSNLNIHHHIEVPEVSMLNRIMKTSIPDNISMVEDHQVIWDQLRAQIDEVKEQSSTDLSIHDVHHYTVLYISVAAVIILGGVVVYLIRSRRAAARAAASPAPQGQEAAGAGPATVAPVDPAPVASHQARSVLKCSEVFTVSGVDKATSPESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G837</accession>
    <name>A0A835G837_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G837"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1072" mass="125267" checksum="7D86157C6B011109" modified="2021-09-29" version="1">MPKTLQLLNELDAVELKGYNTVAGNTFENMMPVLVGMNTEEIEMTCWKDPWTSLDHCPYIWERFKDVGYYTALVEDTAKLGMFNQWKSGFQGKPTDYYLHPFIHEAETLNQETKSESYVKYTKRSKVVSPCMGDKYYYEILLNYIQSLTKTLKKSRLFGLFWETTMTHDNLNDPALLDDAYVEFINKMDSTGYLNKTILIFLSDHGMDTGNILHTKQGQIEQRLPFVFMLMPPSFRKQYRLAYHNLKVNKERLTTPFDLHDTLVDLIDMSAITEKEILDRSREFYTHNRRISLFLSIPRNRTCDMAGIRAMWCACYNEVNVALNSPVLLDAVSYFTNEINEMLKQYPECVSLTADDIVMAKEMVPIYTRYDEWRDFDVIVRMAPGGSMLETTMRLYNDNWTIIDRVKRLNFLDVRTTMAQLAKGNNNRLRSIPTQFRFLFLFTMVFGSSFIIFSLINRTEIFLINNEQLKSSLDFDSEQETSFTIKTEGCTIPGLKAFDDAIKAFNRPPTKLKSCPNANYSLVQSNETHIWINEELLDNHDIPRNKNISCCYQSFYRPNSINDVYSSHVDDRAQYESCENFSHSIQVKHEFVKVTCYYNSNITYKQYFLFARKIHEHKKKQTNINKTQSYYNVIIMGMDSISRLNFYRTMPKTVAYLKYKGAIELLGYNKVDDNTFPNLTPMLLGIKEADLKRTCWPDTNANFDNCPFIWQWFKEAGFQTALGEDTAKLGTFNFLRNGFIKTPTDYYIRTFIYEAEKNVGNILDYNSYICMGNKYFYQVLLDYILDLTALLKNSKLFGFFWEVSMSHDYLTYPMVMDASYESFLKRLDSRNYLNKTVLILLSDHGMRWGSIRLTKQGRLEERLPFVHIMLPPTFKQNYNLAYENLKLNSKRLTTPYDIYATLSDLINLEEINDENILKRTESFYAHKKSISLFLPIPSNRTCSIADIDDQWCTCHKNIKISTSSFDAQEIAEELVEHLNGYLEEHKECAKLALSEVLHVTEMMVGTPRKDEVGWREFMAVVRTTPGDGVFEGTLRKHKDKWSLAGAISRLNLYGNQSHCVHHYQLKLYCYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8V1</accession>
    <name>A0A835G8V1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010788</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000283">
        <property type="protein sequence ID" value="KAF9410008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="260"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9410008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="422" mass="47747" checksum="5F3783EFF46FACA1" modified="2021-09-29" version="1">MSDNNMDHDSPLFKPYICLSTKNMYEHFWEIISEEHGIDPTGVYRGTSDLQLERISVYYNEASVATAENGGKYVPRAILLDLEPGTMDAVRSGAYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNAVLSIHQLVENTDETYCIDNEALYDICYRTLKVPNPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPPSKYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLSIQNKNSSFFVEWIPNNVKTARISEQFTAMFRRKAFLHWYTGEGMDEMEFNEAESNVNDLVSEYQQYQEATAEDDTEFDQEDMEELAQDEHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9T4</accession>
    <name>A0A835G9T4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="16">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_009002</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9T4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18015">
        <property type="entry name" value="DEXHc_RecQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000596">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001544">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="91"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="293"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="586"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9412533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="635" mass="71760" checksum="7491653804E739D1" modified="2021-09-29" version="1">MTTIEKLELELKDVDKEISKVNAELAKWKDRQRVLHEKKLSIKNSINKMKTDTLSSVDWAGTTYQWSEDVTRVLKDVYKIDSFRPKQLAAINSTLSGQHAIVVMPTGAGKSLCYQLPALVKPGLTVVVSPLISLMEDQIRSLTNRNIPAKLMSNTSTKEETSEALNTLKDKNTKIKLLYVTPERFAKSKRFMSNLQACYAAGRLQRIAIDEVHCCSQWGHDFRPDYKYLGILTQMFPNTPLLGLTATATASVLTDVQKILNIPGCLVIKSTFNRPNLFYKILEKPTSQEECLTILEKLLKGRYRGESGIIYTNSIKDAEDIAGGLRKRGLKVGCYHANLEAAVRSQVHTKWHEKYYQAIVATIAFGMGIDKPDVRFVIHHTISKSMENYYQESGRAGRDGLRAECVTLYRMQDIFKVSTMVFSSVGNLEHLYGMVKYCLNGSLCRRLIIAEHFDENWGSADCNKMCDVCSTSNTSEKNINVRLYCKTLGSIIENAEKQDVKLTAQKLLDAWFLKGPVNLRHKGKEPTISRGLGEDIIAFLLLGSYLVEDFHYTAYSTISYIKNGPNMDAVQDDSFELTMPVRKYTSFDLQTPPPNDYKPIVALEQVDESVDDSKSKKRKHDDNSKSKSKIRKTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W2</accession>
    <name>A0A835G9W2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000184">
        <property type="protein sequence ID" value="KAF9412591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="83" mass="9766" checksum="04E70CC995E3C9B4" modified="2021-09-29" version="1">MRDEALTCNVCDRSFPTRRQLADHQQKKRHFGCSACDSLFPSLMALEHHKEEFQHWSDSSYCSHSDSDDSDLETCHEDRHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA62</accession>
    <name>A0A835GA62_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA62"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="676" mass="72783" checksum="487ACB660F765856" modified="2021-09-29" version="1" fragment="single">MSQPKGPSQGQPKGPSQGQTKSRDASASETSRAPSAASLARGSDIVSDFSDNESILSGTTCGSTRQSRKRAFLRQDSRGSPDQTEKPAKRAVIQADLEERISSNEQRARTTRAKAGYGASSVLYADHSVEEMERMALEDQQEILEVASKSSNLKGTFQKALKCRAASLLGIVKELAQRTTSDETRQLQAKVDRLQKEVSALHARVAELMARPEGTSEGPASMPAPSNLEEIIRKVVMEERAFTRACFAGIEDRLLPEKRLRPPLAADKVSERTPSAPGPSTAPAQRESKGKGKGKGKKTTPAAPTAQTVPQDLPREDPLLPSTTPSNQPWVKVVSKKRKGKKKGARWGRPRAVFESAVYGSPRRVHRGDRGGKDRGLLLNPRSMGIVARFLSHGAGWRVDVRGSRGSSSVRKRPHDPALVGDGSVGLSSDEEGLLAPKLPTARRGRQASKGVTASRPRRDAQGRFLRSNTPAASEAESDMGVTTEDPGGESCASLGSSKAELNATRREQRKAVAADEDLRRQVAALSEQQQRRTSTDAAPVVAPAPAPRPAGARTDDEVERIVRLCLLQCGSMMNARIEAISRRLLRKSSLPMRGGGLRRRRDLRLARRSPRRVPEARGGNSPSDQPTTAGSKGETWATVVGRKKARKAAKAASAAARAPAEPQRRLLSLRGGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAH4</accession>
    <name>A0A835GAH4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAH4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="318" mass="34578" checksum="A07AC0D91E81D1EE" modified="2021-09-29" version="1">MKMSFAMDAEAEADALTAKIITMVCLFGISMITGCLPLLISLKWDWFKTGDANLRNSNQLVMGLLAFGGGILFATTFMHLLPEVDENIEHLQGFFMIYLIEELVHLYINSRENKKRNNSFAKPFKMRKSSLTSGRSIEAATTAAELSQIEANGKKEEQNHLPLQDHDSVAGALRGLLIVLALSIHELFEGLAVGLESSVANVWYMFAAVSAHKYIIAFCIGVELLASGTKKWLSIVYIFTFSFMSALGIGVGILLVGGAGAADAGVYSVVLQGLACGTLVYVVFFEVWKGCNGLMQFSCALFGFAVMVGLELIVELVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB12</accession>
    <name>A0A835GB12_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000166">
        <property type="protein sequence ID" value="KAF9413244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB12"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH2" evidence="3">
        <location>
            <begin position="87"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="18796" checksum="1C34417AA0833C1F" modified="2021-09-29" version="1">MAILDTLQLTNQVEKLAQVSRDLRRKHKQIQNQMRLVCEERSELTAIVQSQQRDIAALQQASAQNKKCPTCGVATPDGGDDDDQSSKPTFSVRELRAILHERNELKLKLSRAEEQLSALQADQQHDSGSDTSPSVSTAHPEEEEPPVQGPLPAEPDDAPWKRNSGIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB72</accession>
    <name>A0A835GB72_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB72"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14638" checksum="FB5847B50B32D4D4" modified="2021-09-29" version="1">MPKSQRNQAVPTKTSLLLTLRYLATGSYLRSAADFCGVSPPTASRIVKKVTEAIAQLRTVIIKFPDNLSTLQDGFYEIASFPRKLWDNYNSTDTQTLEEIAAQSPELNYDPRNRLVQEYFLPLLNNNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC92</accession>
    <name>A0A835GC92_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000212">
        <property type="protein sequence ID" value="KAF9411792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC92"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="177"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="391" mass="44003" checksum="FCC475E5995136B8" modified="2021-09-29" version="1">MATQKFGGPSPYKLPATYPKEDYFHTDYVNNVTTNHDVKPPNKPVVAAIFGLGRAGSIHLTSIINNPRIVLKYVVDDRKERFADLKKYWNFGNNVTLLTSNDAQRVYNDKEVNVVFIGSPTWTHHDIVVNSIANNKDVFCEKPIAENIEDTKKCYEAAKSKGRVLFSAFNRRFDPSYRALKNRVRNGEVGHVQILKVTARDSPLPSIDYLKTSGGVFHDCLVHDFDMACWVLGELPCRVQASASALIPEVKAIDDFDTIAFLLTYPSGTVVLGDNSRYSAYGYDQRLEVFGNKGMIKVENERPYHSTQAYIGHEGIKESPIYYSFPSRFREGYKNELEHFLDVVTRGVPMEVTDYQTLAISKIATAAEESARTGKSVELDWSKDGIPANYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCI3</accession>
    <name>A0A835GCI3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000223">
        <property type="protein sequence ID" value="KAF9411496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="3">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="754" mass="76850" checksum="A30BA603C954D155" modified="2021-09-29" version="1" fragment="single">KFTCPQDVLKIIENSFVKNRVVQNRHIILVLTISSYSISNGQKAIFSSTTSSSSTIPSTSIATTTSERPQADIASPCSSHMPGDVDSQTVDLIAVYRLDRRDTQGVTLVQGSQDLQRAYRIGLDVNLTLPLKEVFPAGLPPHFTVVGTFNARGQRRPWSLVRARSESSLQFALTMLPVTKKIVVFIGGSRVMFNSWDIFTPGWHKIHASITNNTVHVAVDCVDLMPEKITTGDFTNATSVTIVSNDDGSSAPIDLQWLSLSCDRYNLSRDTCEEIDKPQFIVATPSPKYDVDPALLADPNEGVACNTTCPAGPEGPRGPKGEQGPRGYTGIPGIRGVKGDTGIPGLPGLKGDRGDPGPPGPIVNASGPGYVGPPGEPGRRGLKGDKGDIGQKGEPGDVGLVGLAGVPGADGKDGLPGPPGPVGPPGARGLPGPPGPTSAINASLIHGAKGDKGAPGRDGRDGFIGPPGPPGHDGMRGTPGPQGFPGANGLPGNMGPPGQPGPTGKSGLDGLPGPIGPPGLPGPPGPPGRPGSADSTPMLPIPGPPGLMGPKGERGEQGFPGLPGPAGLDGLPGQRGPPGLPGIPAPPSIVREAPSISEAEIRNICEDVIKMRLNEFSSNQILVPATVVGKRGHPGRPGPPGPPGIPGLSGEPGPRGYPGETGDPGKPGSMGPSGQKGDKGERGPQGIGVQGPEGPRGQIGPVGPPGYPGRTGSRGDPGREGPIGPRGHPGLRGTCDCPMAYYAYSPQGLNKGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCU0</accession>
    <name>A0A835GCU0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000196">
        <property type="protein sequence ID" value="KAF9412229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033041328" evidence="2">
        <location>
            <begin position="32"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="458" mass="54763" checksum="85C186B7E3B6B65B" modified="2021-09-29" version="1">METRTVIPVSTMWHSKALLLWCGLLIRVVLPMEVQHDMEKHSEVNVESDSVRGRRGVIEEEKYYSMQSHRQDNNMNMNQPWIPGPLPPEDPTTKISITNEVKEVLPLYQTTERVTDKPTGRGARASNENWIKLPLPGHDDLQRDQRDQRDQREQRDQRDNILTPPQPSGDLINSRMPRVNFVTQNKALEASESRNDKESVQRSTRTDEIRTEFVRPDEDRDRNKYKPVFPRQAVYNPPIPEESRRFFYDDRYYPVPDDLYRRDPYYDMVDRRRYYPYYGPRVDRYDEPYDNMVPRKPKRIIYYAHLPEVVRTPPSVDLRYRYSVDPYRRFDDDVYARNGRYDYRFRSRYPYAPLRKDERNYRDLAGAGTVAKDKKIEDKVTPTPILPQKEDKFKTSSHMNVNRNLINSHQYHDSADSYNNEPISHKSYSDIVRPDTTYFRYDEPLLQGPVDEPYQRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDH5</accession>
    <name>A0A835GDH5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="103" mass="11511" checksum="DE1107FDF7B290A0" modified="2021-09-29" version="1">MEERECACAAVMPAPGVGNDSTVQYQLNAHYISIYRCTNNGVQFLKFKIEFPHSLQATKSRVVIITVLQKHQWTTPSDPELPVNHSARTNSNQTCANGHLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDL1</accession>
    <name>A0A835GDL1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_008636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9413022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="491" mass="56146" checksum="63D026E364A23979" modified="2021-09-29" version="1">MCQRNNKHLIEITIKQEYSQDSANLEENNDPKANSEDSYNVPSPTFSTDNSELLSLWGCSKCGEEFYVMSDYTNHINKCNAQPSQEPKPPEEVTKKKFLCDICGKTALSNASLLVHKATHENVFPYKCDVCPYQGRTMDLLKVHKRSHLADKPFKCTQCPKATTTSSNLAKHMRHVHSTTRPFKCSYCEKAFSYQHDMKRHVKDIHLRQGTVECDICCKKFNTKNGCRAELKINNNRYNVTNTYQIGDVHPTDAHYDVYGNLFYVESGLNDKGYYFNANVIKFNTTAPQKIQGLPKDVSYSIAVDKNEKKVYFGTGKGIFEYNYENHYATPISSSTFKLDMIFVDKYSNKYVTEINDGVEELYLLDREMIKKFRFSTLEALNELTIDDENNFYYIKDGKLYVLKSSLSAPICIDNVSYDGMAQIAVHNSNVFIASDDLMYFHENDTGGVKIVDNAPENVTAIAFDNAGDFILGVRGKLLKYKKHECYIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE75</accession>
    <name>A0A835GE75_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_007754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9414276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="206" mass="23678" checksum="3411935FF750926A" modified="2021-09-29" version="1">MDASICTFFFERAVDAISLEIFERCNRNKLWKDVKDRFKKKEIKIEKKPTSDLAPLLGNSVLLLLIRKKRAAVPCLRQDNSKPLVTQTQEKEPADNVQNSSSPAVKSRVVKLNLISEERFQIETSRRHGGLQQQNASSLRKELRPFLITRLKLHRVHFSGEYVDDHGQQDANRAANCDATTSHQPIHSRVFHILFTFEEAGPLKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEP3</accession>
    <name>A0A835GEP3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="77" mass="9001" checksum="2C5BD6538908E203" modified="2021-09-29" version="1">MRRLQKVYYAAHRPQVVTLWSFDPSGRSLFNFKPWSSEVPFKIVKGSAEHEASVAGVWRWVGLQQAAMLSRWWKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GES8</accession>
    <name>A0A835GES8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Outer dynein arm-docking complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GES8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="35077" checksum="ABA30FD6F5C4F3E8" modified="2021-09-29" version="1">MVYDKLFMDFDNAKAQARSILGPTKDAEFLQSFVRVGIGDEEEETPVQKASISKRAPHSAELEVEDEKQAVKERKESDRAAAVVMGSKDIKQSLNLKDKAERSSALQLPVEADAGTLLALARAEMMRERYRTAVLFVNKAIELAPDEKAAYVARSKCYLLLGEPRSALLDAEAALKLDPKDAKALLRKAEALYYCGEFEMSLVHYHRGLRARPDLNDFRLGVQKAQEAIENTIGAVKVVKKAPKKRSKSARPVLGQLNSDKIYLENLLKNPDLAIADKKNDVVMRQAEEAIRFLENREEFWRQQQTTTISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GET2</accession>
    <name>A0A835GET2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GET2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78847" checksum="1D582EF1DBB5B0EF" modified="2021-09-29" version="1">MSTPVNNESSEECCDTPREGLEDIIQLNMEVITHQEKGSIDCEDDGNLGRKRDREDDSSGSWTVVNGRGKKVAKRQTSIDEVRCSNEDEKVEICIYNNEKFPKQFALARLFKTNGIMGIIHVKYMNPYKLMVTFDNESNAEKMMNCKTFIDMGWRSQKSWEVAVSYGIIRDIELDLSIEEFLNNVSCDVKILSARRPNRRCNTNECSDKDSNANGWTASESLRICFKGAHVPSHVNIFGMRAKVDRYILPVTQCSKCWRFGHIAKMCKSTKVICPKCGGKHENCDTTSFVCVNCKANHLALDKQCPIYLKEKRLRQLMNEFNCTYRKALLLYVPPSPTPSSQVNNITLTEKHNDNISQESIRPVQVCNEKITYADITKSVVSLSTQKQSPTLHSNPQPKQKLAQHKKRKQSRPSATTAAGDMDCDSEASCTTSFTSEEQGISSLPDKPNKSSAHRRTPSDPDTTIAADSHIPQIIIPQHISSKFKPKAYWSPDLSKSVAVRRLALANFRRNPTPQNYTFLQEKIQESQRMTRKARGVSFRAFCSNIDSSTSASDMWRKMRWVKGRKSKYQHTDSSLAEKLLNDLTPDYVSPPQPCFQSYNCKLEASITIHELENSVKSKDTAPGCDEISFSMIKNLPDIDEEFADFHKVYTDGSKTKSGCGAAVWDPQMNMSVKLAIDSDISIMHTELIAIAEALSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF16</accession>
    <name>A0A835GF16_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein stoned-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_007294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Stoned B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000016">
        <property type="entry name" value="AP-1 complex subunit mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000022">
        <property type="entry name" value="AP-1 complex subunit mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000018">
        <property type="entry name" value="stonin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012320">
        <property type="entry name" value="SHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51070">
        <property type="entry name" value="SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SHD" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="891"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="940"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9414903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1823" mass="202290" checksum="DE74DA0393D97A86" modified="2021-09-29" version="1" fragment="single">LKKKKKGKKSKRKGEEELFTEEELEKYRREHQQQSTDSGEGTTKENEEWSKFKDLTTGIDTVLKKTQGDLDRIKSTSFFQRIPPKQAEPEKKVPPPRPVVEVTEADFPQLIQAQTDADEDRSEYGVTDDESEEEEQDDIFDTSYVEAVERGEVKLGYVPDSPEEFQDDDIFDTSHVDALIKGQEAKTSKGKKSLDIGIAVGVLTGRIDNVTVTSKRSKRVIPGDLLLDNTDTNDGRPSETITVDESIEKSILDLDTDVPITTPIDLSVSLHTSLIQQTKGDTEKANDFFSADQTQADEEIDEFTLLAAKSLEVNSDVAKLGETEIKAEPVLQESWSAFEADKNEFVFAESIIEDQIDVLDPYLDQDDPFDTSFADAVIPVNQFQANREAVILEDDDDFDPRSDENRVKLNNRRKSSVRIHLTDPSGVRESITSDDIIDKEDSHSVRDLLGGSTTDLTQLGDSPLDPVDINNCEIDPFDTTIVDSIVAPGKVELKLLEQELITSSSSTIYRVPSDPDFDPRADEPKKAERRASRPENLTVSKSVVFNVDSEESLGVDTKVKSNKPVTPYYTRELSITEDASEEAEAADIVPDTLTRTRSDEDLTPKVNYQNKRRHSEYSRTGDIKPSDLFNSAEVEVKTKVLTPSEPLRPSTIIDPFDTSFASNIVPCKTELKLLAKEFSCEEEDNSQDTKHDLLDPSDDIFQAKALTPEPSGSKLTNTNFDPFDTSFAGDLNPGKTEIKLLESDMNEPSAPVTTDVLNPFMIADTEPDAVTSENPFATSNPFSDFGSGYEPPAGDTVPVDIFSGIEPAGIGAKQYEEFSEKKSTPLDIFTSSPVDQDRLVKPTELDLVVATDDHPFSNEEEDQSHHLPARPLPPETQNLILTVTGQMEFTSSHLLDRIPPTRTPSPVSVRDIHSPSPTPEPEHFEEPISDNFDINRNKPTRPPPARPPPATRPPPPRPQPPRPPTATPLTQPVAPPPTQHSDDINLFDAPMPTTIKPTKEAILSLYTAPKKEEKPIDFLSDDLLDDVSTDVKHDISQHLAGEVATSVGALSGQTSFEPEELKSASVTISNVFSSTIDSKADTVAPMDCSEPQIEEASATCNTSPFGDALKDDFSAQSASIDVERNPFENTIDSVDVVAQLPEAVDIFGVKSDDVVMTSSNEVFNNAKENIFEISSISGTGEIPSDPFHSATNETNVMALNPSEALDRQAESAFDVSGMSPSATADWGAPTEVTMQDVFPSSQDAFDAFSAKFDATAANNLNTGAWGDDSSAEAAPSGFEAEAFDPSAGIQCSVLTTPLEDFPRTKYTGPGWEMHLRQPNKKKITGQRFWKKIFVRVALVGDNPVVQLYNSAADKEPFQELPLQACYSVSDIGAQQFDQFGKIFTVKLQYVFYKERPGVRPGQVTKAERITNKLSQFAAYAIQGDYQGVKEFGSDLRKLGLPVEHAPQVSQLFKLGSLVYEDVKQFSCCVEEALFRLAAHRDRALTYKMEEVQITAVDELYVEQDAEGSVLKQIARVRLFFLGFLSGMPDVELGVNDLRRQGKEVVGRHDIIPVVTEEWIRVEDAEFHACVQPEEFANTQIIKFKPPDACYIELMRFRVRPPKNRELPLQLKAVWCVTGNKVELRADVLVPGFASRKLGQVPCEDVAVRFPIPDCWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERFLGAVDTLQESLIEVTSGQAKYEHQHRAIVWRMPRLPKEGQGAYTTHNLVCRMALTSYDQVPAELASHAFVEFTMPATQVSHMTVRSVSLQDHDGDPPEKYVRYLARHEYIKIRSRSLRLYNRQAGAASTTVPPCSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFA1</accession>
    <name>A0A835GFA1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFA1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="17102" checksum="D67440462B4682E1" modified="2021-09-29" version="1">MGSGSVLLLAGGTEIRTKRMRLESMCTVFQAELLAIARATDLVVRGDFGCAAVLSDSRSSLDLIRNSETHHPLATHIRKNIRELEGRGKILQFFWVKAHVGIPGNERADELARLAAAQSRVAPAYDRCPVSYVKRRIRRERFIAGTRGTRRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFE9</accession>
    <name>A0A835GFE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="150" mass="17548" checksum="CF4554A91AA4D277" modified="2021-09-29" version="1">MAEVKNEPEEEEFLVYAEFEDTVNIEKYRTVHVLGVDGKNPIIQMDDTFFTGKYDNALGTYMFFEEDPDPKSEDPLFDKLPEKNLKYVCKTGKLLTMEHAYVTPKEGHDLQNMKLEVEDNIEPINFKTLQDAIEKFKQHFEEESITEVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFT7</accession>
    <name>A0A835GFT7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_007670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000134">
        <property type="protein sequence ID" value="KAF9414416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032753319" description="CUB domain-containing protein" evidence="13">
        <location>
            <begin position="43"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="73"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1225"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9414416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1278" mass="139244" checksum="AE8FB52FFEAA7C73" modified="2021-09-29" version="1">MVESLQMFLFLFKSKYRRKCSWFSPFLCSVLIVLLFCDGVLSKCEDHTCVNGVCKNDMCVCYEGWQGPECQYCGGKVNLTSPTGFITDGPGNYSVSTQCSWLLTPPRLGPTPPPLRVRLESFATECGWDHLYVYDGDSVRAEKLLAVFSGVLENGESSWTRQVIARSGSALLHFFSDDAYAMEGFNVTYAAYSCPSNDHRTNCSNHGECEDGSCRCEPEWTGVACDEPLCPEECNAAYGGGTCTRSGCACSALKRGIACARDAWRAGWAPPTHSGDTPPVAAHVLLPYGDDLLRIGGETFSHSHFLYRYKTAEQEWEVLPTYDSPAPRFAHSAVLYGHELIVYGGVVISDEPERGGGLAGLEGRAGEVTNEIWRVRLNSERPQWHNATPITCSPHRQPPLKHCGGLHVSGHTAVLVYLGVTKKPVMLVFFGHSPHYGYLHLVQEYYVDEGVWAVAATRGWAARAGFGHAAAWDPLSRRVYLHGGLVSESEATQAPSASLFEYDPELRLWRPLQSAPTPRYLHSATFITPGVMLVFGGNAHNDSAAALVASPAASKCYSAGALLYDVRCGVWWNAAGPRAGARAAHAAAPIHTKDRRAVLIHAGFDGRLRSDALIFEAGEGCARHTSEASCLTAAQHTAIACLEEVGWKESFDGTVKACLTEPRFGKDERRCSMAESCAACTAARCAWCGACYVSATYCIRHTHQMALSLEECGSDSESPREACARYHSCAACLAHQHHHTHGSEELSQRACFWDYDTIKCKPVNSSEDIRSVAAAGPCSAPCSTFQTCANCTAEEYGTSQRVHNVSATGTQYARSLGAAYSPAPAGPSGTTASCVRPDTGGTRSTGASASVSTRGEPYRAGCRYRGPGDHCQLCAPGHWGNPLNGGVCQREYTGEPYRAGCRYRGPGDHCQLCAPGHWGNPLNGGVCQREYTGEPYRAGCRYRGPGDHCQLCAPGHWGNPLNGGVCQPCECNAQAVACAPDTGRCYCSTKGLAGDRCDKCDNTNHYHADIYNKGACYYDLAVDYQFTFNLSKKEDRHLSAINFRNAPVKPDVDADFSITCSAHARMNLTVRTRSDPAERTLFAKSEHAFGVEDNVTLTTFFVYVYDFRPPLWIQISFSQYPKLNLQQFFITFSSCFLLLLLVAAALWKIKQKYDMYRRRQRLFVEMEQMASRPFSQVSVELEKGGAVRLHRRGRAGAGSAGAVPRGRAAVLRSLGGLAGPRVTLPTPRRAAPQRPATTTRNYTPYILPPLGGLAVASALVTLGHHAAPLPHHKRPRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFU3</accession>
    <name>A0A835GFU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="3">Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9414017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="507"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="828" mass="93987" checksum="4B6B831172214107" modified="2021-09-29" version="1">MSALLTADWFLLDTYYRKFDLYNMNWSMDDGLENMIVSGAQYAGPMAVVRDRKQFVRITGAAKPVITIYNGVGNVISKILWNSGELVHMGWSDTEQLLCVQQSGDVLVYDMFGAYQRTFNMGQEVRDTKVYKARIFPSPHGVGLAVITTTNRMFLISNVSDPKVRSVPDLPRANEAISSWCVIGSGIIVCRDKEIYKCQPGETRAILMRPDIKNPYTQILSIVPSQNGKHVALFTDSGILWTGSSDFKTTYSEIDTGYIKQPKELMWCGSQAVVGHWDDTLSIFGSTKGQSSQYPYDGPFHLIQEIECVRVVSEMTHELIQKVPFVVERIFRINSVAPESYLLEASRQFQNHSHRADEYIRLVKPNLSTAVQNCIEAAAFEFNPEVQKMLIRAAQFGKCFIMDPELTDLYVKTCRWLRVLNAVRDPKVGIPLTSVQMTNLGERVLLERLIRRRLHCLAVHIASYLQLKDGRTRVLSDWACYKVTQPHLDNESAAREIGDKLRNVPGISYTTIAMKAAEKGRKALAIKILEYETHSKLQVPLLLTLGEGPTALLKATASGDTDLIYIVLLHLKEKMGKREFELTIRSFSLAHALYIKYCANNNREALRQVYVQEDDFQGQAATHIRDAIEQTNPGSIEASLISARECYKKGKNDLGVSICEDGRKLCKQQSSLQETYGTSFVGLSLHDSVRTLLELGEIKLADKLRSEYRMPDRRYWWLRILTLADKDDWAELERFSKSKKSPVGYEPFVDACLKYCKQDEALKYLPRCSDDIKVKYYVKAGFYEEAAEVAFEQKDESALLFVQNKCPLNETTKHAKISSLLERLPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG39</accession>
    <name>A0A835GG39_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_006881</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG39"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="19">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="20">
        <location>
            <begin position="549"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9415459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="769" mass="86505" checksum="4A0B0E396498E07A" modified="2021-09-29" version="1">MTQTTTARQGNGSDKGIFSNTAGFSTLITVTVLSLAWLAGFASRLFAVIRFESIIHEFDPWFNYRSTAYMVQHGFYNFLNWFDERAWYPLGRIVGGTVYPGLMITSGTIHWILHSLNIPIHIRDICVFLAPVFSGLTAIATYLLTSELWSRGAGLFAACFIAIVPGYSSRSVAGSYDNEGIAIFALQFTYYLWLKSLKNGSVFWSICTALSYFYMVSAWGGYVFIINLIPLHVFLLLIMGRFSQRLFVSYTVFYIVGLLMSMQIPFVGFQPIRTSEHMAASGVFALLMAIGALKYLHSLNPKGQWKQLLILGGLAAAGTVFLAVVLLTYAGVIAPWSGRFYSLWDTTYAKIHIPIIASVSEHQPTTWSSFFFDLHVLVCTFPVGLWYCIKHINDERVFVALYALSAVYFAGVMVRLMLTLTPVVCVLAGIAFSILCDLVLREEELPTQQDETEESKSLYDKAGKLKKRTHEQPAPVDPGLGMNVRSVTLILIMILLMLFSVHCTWATSNAYSSPSIVLASYGNDGTRKILDDFREAYGWLSQNTAEDARVMSWWDYGYQIAGMGNRTTLVDNNTWNNSHIALVGKAMASNESAAYEIMTMLDVDYVLVIFGGAIGYSGDDINKFIWMVRIAEGEHPKDIHEADYFTERGEYRVDSEASKTMLNCLMYKLSYYRYDSGGSPPGYDRTRGALPGNRGFKLTYLEEAYTTEHWLVRIYRVKKPDEFNRPRLPLAKRTVPTSNTISKKTTKRRKGMLKNKPTIVKGKKVVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHW7</accession>
    <name>A0A835GHW7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_006842</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000109">
        <property type="protein sequence ID" value="KAF9415523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHW7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9415523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="524" mass="60777" checksum="0CDDB7FD68E6A2BF" modified="2021-09-29" version="1">MIALYLLLAIPLALYSIYLISKRKYQYWERKKVSHLPPKPILGNFSEYILQKKYFGRVEQEVCQTFPEEPYVGTYLGTEPTLIVQDPELIKAVMTKDYYYFSGREASNYSEKELITRNLFFSYGDKWKVQRQNLTPLFSSAKMKNMFHLIEKCARVFENLIDQEVQKSNDIEVRALIGKFTMDAIGNCAFGVETRTMVKTENNPFTKIGNVIFDTNWFRAFKLVARGIWPAIFYGLGYKSQPVDVDKFFTNLMTETFKGRDYKPTTRNDFVDLMLKLHNQKTVTGDSMSNMKGDSGKKLTLEIDDEFLISQCFLFFAAGFETSATTLSYTLFELVKNPAAQDLAFQDVENYLRRNDNVLKYECVTELPYVEACVNEALRLYPVLGVITREVIEDYTFPTGLKLEKGLRVHLPVYHMQHNPKYFPEPEQFRPERFLGDAKQEIRPYTYFPFGEGPRLCIGMRFAKMQITAGIITLLKKYRVELATGMSEKVQFEPRSVITAPIGGIRLKFIEREGWQQRVLKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIA7</accession>
    <name>A0A835GIA7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_006191</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with SYS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIA7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04160">
        <property type="entry name" value="Arfrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000509">
        <property type="entry name" value="ADP-ribosylation factor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="19">
        <location>
            <begin position="932"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="804"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="849"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9416430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116078" checksum="5DB69C01B740F251" modified="2021-09-29" version="1">MYTLLHGFYKYLVQKDEYCVLILGLDNAGKTTYLEATKTKFTKKYKAMNPNRITTTVGLNIGKIDVDGVRLNFWDLGGQQELQSLWDKYYAECHAVIYIVDSSDRDRISESKETFDRMIASEHLSGVPLLVLANKQDIPDCMGVHTVKPIFNQNAHLIGARDIMLMAISALNGFNPAFNIATIKQVVNEAIERVAPVSVRMPTPTRLRDLIRQIRAARTAAEERSVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYPAHFGQLECLKLIASPRFTDKRVGYLGAMLLLDERQDVHLLITNCLKNDLNSNTQFVVGLALCTLGAIASPEMARDLASEVERLIKSPNAYIKKKAALCAFRIIRRVPDLMEMFLPATRSLLTEKNHGVLITGVTLITEMCENSPDTLNHFKKIVPNLVRILKNLILAGYSPEHDVSGVSDPFLQVKILRLLRILGKNDAEASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIKSESSLRVLAINILGRFLLNNDKNIRYVALNTLLRTVHVDTSAVQRHRTTILECLKDPDVSIRRRAMELSFALINGQNIRSMMKELLTFLERSDAEFKAHCSSAMVLAAERYAPSNKWHLDTLFRVLLKAGNYLRDDTVSSTLQIVSSAAPERQAYAAMRLWTSLERSAVSGDATEKQPLVQVAAWTIGEYGDLLVSEASNAISMVDEDGVDDFVRPTEEYVIDIYQKLLWSTQLSINTKEYLLLSLAKLSTRFTTQPSQDKIRVIIDTFGSHIHIELQQRGVELSQLYRKYAHLRPALLERMPAMDAPGGHAPDDADNDALSDISPDHKPDHANNDALLDLIIGSDSLTNGDVEHKPSQPPASNNNSSSNDILDLLSGLDLTPTAPASVMNNNVPSPGLTSGLSPGLTSAAPPASLLLDGLFAAPVQTPTMQDLPTVTALEKNGLRIVFGVQRGGDSVTLTMRAQSSSPSTLTDFLFQAAVPRTFQLDMMSPSGTVLPPQGEITQVLKITNPSRSALRLRIRVSYNVDGVPVLEQAEVNSFPPDLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIT4</accession>
    <name>A0A835GIT4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="75" mass="8945" checksum="B2798CD48E0586A8" modified="2021-09-29" version="1">MTSGVTKRQVLSMYKLLMREAEKFPNYNFRSYALRRIRDGFKENKALTDLKQIKQQYEFATENLSIIKRQVIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ96</accession>
    <name>A0A835GJ96_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="233" mass="26433" checksum="2ABFC8F7F4719352" modified="2021-09-29" version="1">MNRHQAGDRCGAKSSSLKKEAPAGTLAPAAAGAAPEAWFSSRWARVALTSYSTYHVASILDLNLDNTIQFTNLENHENDTHDEKVNIFAAVILDFNLDSTIEFTTLENHETDPMMKKLIFFAAAILDLNLTSTIEFATLENHETHDGKKEYHTVNKEKENMLALKLLSSLERIMFRAKTFFLSVTKIFRKVRARSGRRLVKQQQSPCHGTVQRGIYSDEAKASCWMWMRELHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJA3</accession>
    <name>A0A835GJA3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJA3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="206" mass="24024" checksum="A7C2E87BE3DF9DB6" modified="2021-09-29" version="1">MAPVYQLKFFNFMGVAEPIRYLFAYGGISYKNVEVNKDADWPDVQKSVPFGKLPVLEVDKKVLYQSVAISRYLGKLVGLVPADDLEAAELDAIALSVYDFGTKVHEWYHESQKERKEYLRAELEDVWCPRYLRDFEDIVQKKGSYFGGQKISWADLYFVGIIESVEGMWGSKILEKQYPLLYRIYVHVHEIPAIDNYVSNRPHYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJF3</accession>
    <name>A0A835GJF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="181" mass="20685" checksum="B637A3D66E6D4D29" modified="2021-09-29" version="1" fragment="single">CGSNFVTRSKLQSHINRTHLGLKYNKNIVCEVCGKKCTSNATLKYHQRTHTGEKPYSCTSCSKHFVDSNQLRIHTRTHTGEKPYVCAACGKRFSQKPALNRHYRVHTGAKPYTCQYCSRTFSQSNSLKLHVKTVHLKQPANRKSKSKTTFETKIEKNAENHENTEELQIDGSLQAIRAFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKF6</accession>
    <name>A0A835GKF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="230" mass="27235" checksum="A8E0CC6E7CBAE100" modified="2021-09-29" version="1">MNILPKKRWHVRTKENIARVRKDEAEAAEKERQEKLRVEQADREARLSVLKYKSKQKLQDSGIVQSTTEPIQETVNEHINLFANLDDAVKTTNREHDNEIKEKKEEYEKKIGYLTYLGQDTNEALGKKNWYEVAPETSRFSRSSDIKDTYDKLVLKDVDGKPKVKEPDVKDGEKLREARLKREQQEKYRTELFLKGLHNSNETKEVEKETRVKPKYNLQFNPELARQNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKS1</accession>
    <name>A0A835GKS1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKS1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="327"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="590" mass="65953" checksum="10BB3F1A797F1169" modified="2021-09-29" version="1">MLRNTEFQCKDQSCIPSDGRCDGKYDCKDKSDETHGLCRQIKCRSNLFTCMYGACVDRDAACNGVDDCVDRSDELLPRCRNETRIKKNQFSCFDGTKIPSSDLCDGVMNCPDGSDETLHSCAGKKCRGNLFQCLYGACVDQDADCNGIQECADGSDEDKQLCSNNDTEPDINNRFNVDKPCILPPYPNHGSYEVADEKNASPNDVFSSVHLTVTCDEGYAVAGDPKIYCNNGNWSHRNIGSICVKHCTLTPEPSVTYYCLESNNVEGRRLCRNQEPEGTQVQPECKPNYYIRDVSSTKMICIDGIWSPKVTCVPECGRLTPKGSGLAIGGRYAIQAEISWHAGVYKKKESRYEQICGGSVINNNFIITAAHCFWDEQLYKVADPSLFAVAVAKYYRDWDHENDTDAQKSDVEQIHVPPLYEDMYGNFDRDIALVKLKTPIEYTVYLRPICLDFSEDFEEKQLKPNSLGKVAGWGYTTPEGDYPHALKVVDLPYVPPVQCRMVTPDNFRELLTSDKICAGFSNGTATLCKGDSGGVLAFPEKVRGVWRYYVRGITSSAPNPKEGAKCNRLAVITFTRISSYKKFIQKHILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKT5</accession>
    <name>A0A835GKT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="172"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="360"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="53209" checksum="1A08C63CB3CDE8D2" modified="2021-09-29" version="1">MDDFKKMDENKDLPIHRKVILGSLSRIISTTLLIPLDVVQMRYRFPDTWCAQMFRLMVKTKDYPGSYEMMTATKFRKRVYSTLRWGVYYCLYDRHQKNCRRYSRHPLSNSKYLLTRRPIVMQAIRHGNSTAVLDYTQEKKKMREHNVLSKFAKHIGSQIHSAISGIIVNKNTTLRWSLNAAFLTAVIASMLLHPLDVFKVRLQMYPEVWGISLLRNMLRCEGIRAPFTGLSASILRQTTYTATRLGTYYCMYEHQKRKYNRAPSFPEKLTIGMYAGLLGAFVGCPSEIVLVRMMADGPVDPFRRYRGLVDAFVKIWKSEGFNTFWRGGMLTMSRSVVISVAQIGTYAQARSYLVEQRKAHGFLLHIYTSMLASLVTAIVTLPLDTFKTRYQVATNESHRDVYQKFKQETGMLGLWRGFTPYYVRLTIHTLITFYLLEVLFKVHRKQRRLRKRAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKW6</accession>
    <name>A0A835GKW6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKW6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21080">
        <property type="entry name" value="DHD_Skor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000001">
        <property type="entry name" value="SKI family transcriptional corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000003">
        <property type="entry name" value="SKI family transcriptional corepressor 1 homolog-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF26">
        <property type="entry name" value="CORL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="345" mass="38510" checksum="105539F8F848B528" modified="2021-09-29" version="1" fragment="single">MEATNLALSPRESLKPRSEHKTLQLSGKPNQVGTVLLYGVPIVSLVIEGNERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPVSSRRCGMITRREAERLCKSFLGDNAPPRLPDDFAFAVHHECAWGCRGAFLPARYNSSRAKCIKCAYCGLFFSPNKFIFHSHRVGPGDKYIQPDAANFNSWRRHMKLSGTPPEEVVHAWEDVKAMFNGGTRKRMLSAARRVPFRRPESEGSSEAKRPAASPPSAHAPVPRLADYVWGARLPLPYALPWLKPTLWTPVLSSPLRSSHTRSPLRSPPPSSPARSPKSDRDSDESVDIETTEEDQPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL01</accession>
    <name>A0A835GL01_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL01"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20578" checksum="8115C8A7EB898DCF" modified="2021-09-29" version="1">MNIDNNGYLDAHDFHCLALRTCVLEGKGDCSAQRLQKYQHIMLSLWEEIAQLADFDKVPDYDGTITVDEFKQAVKNSCVGRRYEDFPQAMKAFIETNFRMIDINMDGVIGIEEYRYDCVQRMVLEDIKVIDDAFNSLLNDDDRRKGGLTLSRYQELFAQFLGDAGDDCQAKHLFGPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL30</accession>
    <name>A0A835GL30_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL30"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="18150" checksum="B2E2363911F91727" modified="2021-09-29" version="1">MASNRGIQIGSAWFQRKLNLRPQHRGVHLVTEEILKQVPELSQFAVGLCHIQIMHTSASLALNESWDPDVRDDMEMMLNKIVPEGLPYRHSCEGPDDMPAHVKACFLGSSLTIPITDGKLNLGTWQGVWLCEHRNHAGSRKVVVTLSGCPRDSPLSPVSAASCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL92</accession>
    <name>A0A835GL92_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein 131</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL92"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056311">
        <property type="entry name" value="TMEM131_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022113">
        <property type="entry name" value="TMEM131L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24495">
        <property type="entry name" value="Ig_TMEM131_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12371">
        <property type="entry name" value="TMEM131_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032809552" description="Transmembrane protein 131" evidence="2">
        <location>
            <begin position="27"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131 second Ig-like" evidence="4">
        <location>
            <begin position="174"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="37641" checksum="249AC293BEBB4D39" modified="2021-09-29" version="1" fragment="single">MYRKIVWCYIFVLTLLELSLNTKLTAQGKSHGVTVHDSLIEGITFQEWGKDSGAEGDGAGARGGRAVAAGALQLSPPALDFGRAALASAHALTVTLTNTANTTMHLASVAGTTPDFHASFFESKTLAPRGNTTFTVVYLGRREGPVAAHLYIHTSLGVHKYPVSAVGVASEWGLWPLLGLRVPQNASVEPLVVLHNPTDSEVQVSEVYSSAPWLRLALPGGGRAAPRAAWSVAPHSSRALVRLRVAPPGGGPATAYVRVRGAALPAGALLLPLQARAAPPGEYAAPPQLRLLPRGSRDAPDTLELRAANSAPTAVRLQPQLWAARCGPAPLDPPPPPDPPAAPAAPSAPAANGQTDKGTANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLA2</accession>
    <name>A0A835GLA2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein with SprT-like domain at the N terminus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_004784</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="17">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9418354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="650" mass="73024" checksum="D1B5430C6D0539B6" modified="2021-09-29" version="1">MKTMMNLGDPELELIDPTPNVHTLFIHFDKMFFWTKLASRAVVRWSKRMYSCAGICSYEGRGGLCDIALSEPLLKLRPRKDLIETLLHEMIHAFLFVTNRDQDRDGHGPNFQAHMHRINKSAGLNISIYHSFHDEVKLYQTHWWRCNGLCQTVRPHFGIVRRSMNRAPGPNDFWWEDHKRKCGGTFIKIKEPEKKARGKAAPVSKPNADITKYITSNIKTINNIPNTTNSNSSSKPVLKDSSNTKGHTNIRSNSSSTLVVSKKGVVFNPTSGKPPAKPVPPVPLFTGSGQTITGRSQTNDNVTETVRNIWANKQIPLKPNTSPILQKTTKVVDTGTSSNKDSNKVVDLNTKKHKADTNIEPPAKIKKISDHVNATSILKDLYGDDYKLTQSNDSKKLIAVNVKVDLVACPICNAKFSNEEINKHLDECLNKDIIEKLSKDEIEENKPSTSKTDSVPAKDLVKPESNNNDNNVIDLTWIHKETTSINVKGKRKTESQATLEIEKVNNRIVSKESSRRRSDSFITKERGDSLPSETKMKKVEEVIKIEPTAGPSAEKEFEQICPCCGMKFDKPVEQHLDECLTFFDNNSTIPDEGASTSYTNNSTVLIEDDEDDIFDETQILNATGTKTPCPCCMKMVEIEDMNAHLDFCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLS4</accession>
    <name>A0A835GLS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_003525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLS4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9420112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="176" mass="20699" checksum="AECB609C64035978" modified="2021-09-29" version="1">MDYLKTNFPSQPEDAIKYPDSLQPSLYQPIFEQEVNSSPGELIHPGYLPFFYDYRAVDRGLCEGREACDWEWGEWESHVVVKEESEEQARAFTEGTQSPAGSRKERTAFTKAQIRSLEAEFTRANYLTRLRRYEIAVALHLTERQVKVWFQNRRMKWKRTKGASKHQKKKEVNGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMZ3</accession>
    <name>A0A835GMZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein argonaute-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_018360</name>
        <name evidence="11" type="ORF">HW555_002658</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000928">
        <property type="protein sequence ID" value="KAH9628144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMZ3"/>
    <dbReference type="SMR" id="A0A835GMZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="277"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="10">
        <location>
            <begin position="569"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9628144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="912" mass="101589" checksum="3F5EB2B0A3AC74D1" modified="2021-09-29" version="1">MYPVGQAPAGDTNAGAVSVAGAVTAAASTTGAAPGVPSTAPATGATAPGAAGGAGAMSLVSPAAPLADLPTLTCPRRPNLGHEGRPIMLRANHFQISMPRGFVHHYDVNIQPDKCPRKVNREIVETMVHCYNKIFGALKPVFDGRNNLYTRDPLPIGNDKVELEVILPGEGKDRVFRVSIKWVAQVSLFALEEALEGRTRQIPYDAILALDVVMRHLPSMMYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRDINDQRKPLTDSQRVKFTKEIKGLKIEITHCGTMKRKYRVCNVTRRPSQMQSFPLQLDNGQTVECTVAKYFLDKYKMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVPGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVRRANFNTDLYVKEFGLTISNNMMEVRGRVLPPPKLQYGGRVSSLGGQQALPNQGVWDMRGKQFFMGVEIRVWAIACFAPQRTVREDALKNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFKYLKSTFVQLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSLRPKVFNEPVIFLGVDVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIVHEMSSMVQELLIMFYKSTGGFKPHRIIMYRDGISEGQFLHVLQHELTAVREACIKLEAEYKPGITFIVVQKRHHTRLFCADKKEQSGKSGNIPAGTTVDLGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFGSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSACSEDRTPIAMARAITVHAVTKKVMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN64</accession>
    <name>A0A835GN64_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN64"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="126" mass="13827" checksum="B56F2B8A80BFCCD5" modified="2021-09-29" version="1" fragment="single">MKHPLRSGLHRRNFISNHGDDSPIDTIRLVSPINRFAIFQGNFSHDDDDYPEKPYKLKTKIVLAALAVLVFISALSGYLIGSADYASRRAAEPPDPIAPLKPSASRLHVFQKAAVCTDAPQCSQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN67</accession>
    <name>A0A835GN67_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN67"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24569" checksum="9B4F70BE2A94837F" modified="2021-09-29" version="1" fragment="single">VFQIPSDIRIYVLVEVVHWSSETGSNKQAIKRESKSPTKEPRVCVGNTWKTVGKYRFWQRVACVQRRTDNATMGTTTDITDLLPSQEVGPPRNGTYDPNYGHEPYWADGGWVYDKFVPTKNGSKYMCGVRCALLFLEYGKICARDENYKLQTFESFCAMKSSDCSGKNGWTPLHKGECYRTLITHYTYDARGRAEKAILEVSKRHRNLEPYVGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNJ9</accession>
    <name>A0A835GNJ9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNJ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="35283" checksum="AC615C0CEEB7B8A4" modified="2021-09-29" version="1">MGKMASNNFRARKLVHMVVNTDVCHDNSVRNTELSTSTLTIEIEPEDTKKSEDEIFTDRQDIASSQDVVNADFSLNLSSAALGDIRVSDYSFSKDESFGLLCNETLTHSLMGSPVADFGTEDEPTTSQGLQEIENQRSNESCPDVDNAPTTSNNQILVTDSVMQNEDNEAANRLVCDALKGTTKKGTPRIRKLYTESTNTRKEAKKQKKIEKFCVKPACTTSCKKNVERNFQSQTTEHDGELREIGFLKMKHIKSHSIPDPIQNSSPRGITEARKSAIISTLTRTTRDNKKSFNRVFLETAKLQVLHLRLRRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNK0</accession>
    <name>A0A835GNK0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNK0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF46">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="27916" checksum="40F237F7979A01A0" modified="2021-09-29" version="1">MHVEVLNIFPPPTVYSPGCDVTKTRWRAYVTVPSARILGGPDLHVDMGSTINLTCLIQFSPEPPAYIFWYHEDEVSGRKVIILMDFLYLLYLVSHTVWLCEPPEQIYQCGCVVCEAGDIVRLIARRRVGRHGEGRGHHLVPAGAGRRARRLRPLLLLTLQRGGRVGARARAQWRAAGGHADGQRGAVQQLARDRGAAGAVRAARAAAARAARLQLIARASPRTCSAVYPDSNYSWTRTRNTSFFKFFIEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNP5</accession>
    <name>A0A835GNP5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan anchor biosynthesis class U protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNP5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1189" mass="134409" checksum="7BFB56D784085B47" modified="2021-09-29" version="1">MGVILKYVVAGLLRYWLINLDYWQTIANRVEIATPLNSWKRLIEGVYLYDHNINPYEGDSFHESPIMLVFFYHIMKKVPFILPVLFTFLDLLTAHLLYKTSKAFIRLLKESQEKQLAEVADESKPMLLDDAQLKESAEYVLSVYLFNPYSVLNCAGMTTTVIQNLLVATALWGASSGQRIVACVFIALATHQALYPVLLIVPIALILAEVNKGCTKCSYIRTLLVFVLSWGFLIYLSAYIMDGSYKYVYNTYGFILTVPDLKPNIGLFWYFFTEMFEHFRVLFVCAFQINALALYVVPLTLRFKKDPILLATVLIALSSIFRSYPCVGDVGFYLALLPMWKHLFTFMQQKFIVGCTFIITSALGPTVWHLWIYSGSANANFFFGVTLSFATAQIFLITDLLFAYIKREFTLKHGSSRQVDGKPAKLLHLMNVVQPQLKVSWAFIVNCATVPSIPNHLRDCYRSGIPDLPAPRRLDVFLSLLQKLELQSQLDMRLLSSGLLRSLRLDGIEQSSVNAVETEFLLPYRASSFQFHKFKILMDIFLPSQNLVQVDEILPIAEKCLMHKMLSSAVRQWERGDENLVCPLSAQLAQSNNNMETQSNSRVISRCPIEEGVIQTEWGTISPGTVIAAVAASLESQRVSVTDILNANIFNEDVAEPLMVSAKQEWVDDIETLTPAVNDTPILRRQSDVADIGNVWVATLAGDLAEVVVNQGPRVGSIAQNMVIGSNNRWNDTLLPRDHYLFPQNLTVADWQFTDAEILAGIDGLILAYHIPKWVEQRRTLRLSQVLDMYYSNEGVSFDPSIKACNRQNLFSNIVNKGDLLVETSRFSHVLSLRQITVYVPVEEMERMAVAAVNAFMDYAPTLLRRVHKPCDMLGGAPVIDLIVATDGSWKGYDVEQFMSWIGGSLEINMQRGSISLLHGNTGAWIAPPSYNLTTMFSYIKNFTDEWPNRLNLPTVMSTILQHSLNKSLAEIANNATGGPSTVVLIVSPSDRPSAPEMERTRELMTLLRANYFDVYFSYVAEDLSDFQNINNEYLDYSELFITTPSASVQDIVAAVDTFLVKSDIPQRLIGPQCPFNNTVFNQIEYEDFVLPNRPMLYRIHPFYLRLQTLVRVQFRNDGQGQLLVCMWRGAEASHNCQTIEQRGIHMFNLTQPCPSPDFCLPAYFTVTATSTDNLCASEKRKLVVTFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPI8</accession>
    <name>A0A835GPI8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_017950</name>
        <name evidence="1" type="ORF">HW555_003802</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9627975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPI8"/>
    <dbReference type="OrthoDB" id="7291444at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9627975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="250" mass="28796" checksum="DE8E69DAEC20F1D8" modified="2021-09-29" version="1">MSTYPQHGDILKSGHPYYPESNVAKYGGYDPDKYALADVSKTIATHESLKPGCAPHLTQYCIAKYLVPLSKSLTEVPARPTISELPDAVIDHMVTKDKAFWVDKPGLNDYTIHDAYNQYGIFPDVVRPIPQNVFPRSYQYDLDCVRYRRSTACDGLKDTDGKPKKPLSAHCRDCRKLHIPPLTPFQLAWAKDTGQKRWRYYPDLTATLTREEIRASMDNVGRPFQNEACNWYYKNYPPFKYECIVRKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPI9</accession>
    <name>A0A835GPI9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_002063</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPI9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF35">
        <property type="entry name" value="IONOTROPIC RECEPTOR 68A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9422254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="609" mass="69952" checksum="14D714258CABEB94" modified="2021-09-29" version="1">MTVVEDYEDLLSPNFVTLESLRAARKEGCNVYVILLANGLQASRLLRFGDRHRILDTRAKYIMLHDFRLFRSELHYIWRRIVNIIFVKYHKKILGVSKSRPWFELSTVPFPNPIKGVFVPRRVDIWKNENFYYKRPLFADKTSNLNGEVLNVVYLDHVPSVVVVKNNATTKIGGVEVEILHTLAEKMNFKPKPYQAINADLHKWGQKQPNGSFSGLLGEMVNGRADVALGNLQYTPYHLELTDLSIPYTSQCWTFLTPEALTDNSWKTLILPFKLYMWIAVLLVLLITGTIFYGLAKNHMNLQEYKKLRVTQTKHDEDNDAKPGLYLFGEIINSILYTYGMLLVVSLPRLPTGWSIRLLTGWYWLYCILLVVSYRASMTAILANPAPRVTIDTLRELVDSKVTCGGWGTQSKKFFQESLDDNTQKIGEKFETIDDPLKAANKVAEGVYAYYANSDFLKYISVVRKTALKGSNDNSTNTTEVTAKKDTQRNLHIMSDCVVNIPISIGFHKNSPLKPLADVYMWRVVEVGLVEKWLNDVMYPIHSLETNEDEVKALMNLKKLYGAFIALAIGYTLSALCLTGELIHWHFIVKRDPNFDKYALHLYYRKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPL9</accession>
    <name>A0A835GPL9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPL9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="339" mass="37135" checksum="5D95F8796E2F109F" modified="2021-09-29" version="1">MSHKPTPYSPNFPPSQGYAPPPDGKESYPLNPQVGYPGPPPPGPQLPPGAQPLPGMQPGFQPGFQPGFQPGYPHPQPGYPHPQPGYGPPGPVVQQPGPQVPPGGWMTVPQGLSNCPPGLEYLSMIDGLLVHQKVELLEAFVGFETNNKYTVKNSVGQKVYYAVEDNDCCTRNCCGPMRPFDMKIMDNFRNEVIHLHRPLACDSCWCPCWLQSMEVSAPPGTVIGSIEQEWSICKPCYVIKNAAGDVVLRIKGPLCTFSICGDVEFHVYSKDGETKVGKITKQWSGLAREAFTDSDYFGITFPMDLDVKIKAVLLGACFLIDFMFFEKSGNQESDRPGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPT1</accession>
    <name>A0A835GPT1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="56" mass="6073" checksum="919F662D80A2779B" modified="2021-09-29" version="1" fragment="single">MFKDVKNYRVICCGGDGTVGWVLETMDKVQMDTQPAVGVIPLGTGNDLARCLRWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPV5</accession>
    <name>A0A835GPV5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_012280</name>
        <name evidence="6" type="ORF">HW555_000792</name>
        <name evidence="5" type="ORF">HW555_002940</name>
        <name evidence="4" type="ORF">HW555_009372</name>
        <name evidence="3" type="ORF">HW555_012599</name>
        <name evidence="2" type="ORF">HW555_012671</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000493">
        <property type="protein sequence ID" value="KAF9407237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000480">
        <property type="protein sequence ID" value="KAF9407358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000542">
        <property type="protein sequence ID" value="KAH9635611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPV5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="253"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9635611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="435" mass="48640" checksum="B528D3A07F62673A" modified="2021-09-29" version="1">MTEAGFVKAQSDNLPKIDAFMMTAYFASNPDFTSAEIRGVKAARSTRESYGDSAVGYVQVKRDGDICVVKARITPEHNVRQKCYAVICTCNETEETILSVQCEDCAAHLGGCKHAIAFLAWLHRRSEDPSTTSIECYWKKSKLSSIGTSKKFIKAKEMYKTPKHELVPTSLNTESFLTVVKNNCTLVGDTKNHLMKFYRAPSTVEKLSIHHLLSTSKATNPLDFIEYCKLIMTADACKGAAIATLEQNDCPLWHELRYGRITASKAYDAAHCNTLDGTLTETILGASKLRDTEAMERGRLLESQVLKEVEKICKIKISKCGLKLNSTHPIMGASPDGENSVYSIEIKCPTSEKAMGRYVSSGNKVTAKYMAQVQLQMHFSNKAKALFCVADKDFEKTKKISILEVNYDQQLCENLLEKCDIFWNKAIFPKLNMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQJ7</accession>
    <name>A0A835GQJ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 120 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM120 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQJ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 120 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="39000" checksum="8C8E0629766BB057" modified="2021-09-29" version="1">MDVEECLKEWEDLVVDYKRLEVVNKDYVTKLEEVGELQAACMKEINHQKYRMSIIAAALKRLEKKGVTKDDRVANLEKEIMKRKAMLREINATLPKQNSLYLRIILGNVNVSILNKNDKFKYKDEYEKFKLILSAIAFVLAVANLYIDFRPLQLILLFLLVWYYCTLTIRESILKVNGSRIKGWWRLHHFISTVVAGILLIWPQNEPWNLFRHTFMWFIAYISVVQYMQFRYQSGVLYRLKALGARHNMDITIEGFHSWMWRGLSYLLPFLFGGYVFQLYIAYTLYSLSYHPEATWQIPALSLSFLTIGIGNCATTLIVIPQKLNEQVQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQY0</accession>
    <name>A0A835GQY0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032485313" evidence="2">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="449" mass="49644" checksum="E469B19F3553D268" modified="2021-09-29" version="1">MKLFWCCFCAVIITISGAALDVEKTVKQVQNILQSNQLLPRLTRDEIIQLLNDIRAEDAKSTSTSIESKEVKKETATTPYSTIENEINPQEPKLNPKVVDSKRNEKIPSPPTTIETTTKKAEPTLMVVLPYTPRDGSSLQELYTRPPRTEVVALPSTTPRPKTTQIKQKTAKPNLPEKLIDNFPEELQAFLDAHGLEGKPGQDHFLLPLEGFKPLPPPKVVDGTVQLPENILLTYDLIAPSSDSKTKNDGTYSLSPNNFLYEPLRPELPYELDTSSSETKEVSLPYDMPVRKTKSVHVSNYEPIDYESVKVIPLNKGINPINEEVNTNNDQSKRQAEEATTTTTEKVETTSAETTTTTTTEEPKTNAVSDSSVSADDSGASIADLEDSFGGAAPSVPGDSELPPPRKNGFYWMLDWNSFLEVGDGDTKVNIRFEPKLGDPQMFLPVTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRE5</accession>
    <name>A0A835GRE5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_015002</name>
        <name evidence="12" type="ORF">HW555_000842</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000547">
        <property type="protein sequence ID" value="KAH9635509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRE5"/>
    <dbReference type="SMR" id="A0A835GRE5"/>
    <dbReference type="OrthoDB" id="5952856at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9635509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41803" checksum="E3E72BBEE0B4846B" modified="2021-09-29" version="1">MCDDDAGALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNCPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRU6</accession>
    <name>A0A835GRU6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="429" mass="49575" checksum="24EDEDA305AD50B3" modified="2021-09-29" version="1">MPMKSSRARRILGLLAENSTPDCENTITSPDYELEYEKPNNSNMNSNNEVQNEHNIPTETEDKTIAESIEHFEKTNEVAIPKTHFQHLVPYSDSDISLSDHEDTRYTTTEAENKNEENTVRQSSSTSSSSSSSSSSSSDSDSSHSTNTRSLARTARHHVTVNETDDSEVIENTPPQHFENRRNEKNRHPRENSTSYYSSPIYTDESDIDLSDTDPTFTIMENRRKRNYIFYDSSSSSTSSSNSRITPKKGRKRSKKPSQWKQNKMKRLRNKGKTYISMSKTRKNVPARCLKEPCSEKCRLKCTTKINRDSRYELFRKFWDLGDLAKQRAFISASMIDVQPKYKYTNSERPRNNNKAFHFTVDNTMIRVCKTFYKATNKRKKMKALTEISLQQAYSKKLEISANKKKDLKELITKALIPSFYAGFYNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRY7</accession>
    <name>A0A835GRY7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_007336</name>
        <name evidence="14" type="ORF">HW555_001484</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000439">
        <property type="protein sequence ID" value="KAH9637622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRY7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06648">
        <property type="entry name" value="STKc_PAK_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="13">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="287"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9422941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9637622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="578" mass="64099" checksum="D632DEE4F26EA0CB" modified="2021-09-29" version="1">MFSKKKKKPLISPPSNFEHRVHTGFDKREGKFVGLPLQWASLVGNNQILKSTNRPLPLVDPSEITPTEILDLKTIVRGDHRTTSVSSIARPIPSSIPQQPVQNGVVLPKTSNVARSNSLRSTSPPRIRRDLRSQPNVPPSVPEESPPVPPAPQQYLSLRREHSNYTLNKPIAESPVEWSQHAHEATIRQVPEINDNHHPMTYQNIQNANVPYQHNHPPQPMTHGPHGLNGNNINMGDAYGVSRAQGAPGAAPHLPLAASKHELRLTHEQFRAALRLVVSEGDPRATLSGFSKIGEGSTGVVCAATDTRTRRRVAVKMMNLRKQQRRELLFNEVVIMRDYPHPNIVEMHASYLVGDELWVVMEYMAGGALTDIVTRARMDPEQIATVCKQCLKALAFLHSQGVIHRDIKSDSILMTADGRVKLSDFGFCAQVSEELPKRKSLVGTPYWMSPEVISRLPYGPEVDVWSLGIMLVEMVDGEPPFFNEPPLQAMRRIRDMPPPRPRGAARCPADLLSFVECALVRDPAQRQPASRLLQHPFLRRAGPPALLVPLMPPAHHHSAPNDPAANQSMSPGPPQSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSL4</accession>
    <name>A0A835GSL4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSL4"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF411">
        <property type="entry name" value="LD23667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="171"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="265" mass="30553" checksum="4B3D5A45175E0887" modified="2021-09-29" version="1">MESSYQGGVSFEDRDNNFQRLSQTIASNIKKISQNVSSMSKMVNQLQTPQDSQEHRNQLRQIQNYNQKLARDTSSLIMELMKLPTDQPAHKMTRERLRDEYMITLNSFQSTQRLAAQKTKEDVRKVKAQSASINIGDPFAMSGDSSNKELMEMGEPTLREQEQVMQTERSLVELEERERDIRQLESDIMDVNQIFKELGTMIHSQGEVVNSIESSVEYATVNVESGTQELREAANYKNKLRKKKVYLFLALIIVVSILLIIIFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSW1</accession>
    <name>A0A835GSW1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSW1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="310" mass="33926" checksum="B25DA2E32E942B4E" modified="2021-09-29" version="1">MPTFLTPGRHGYSVRFSRTRPDTLAVATSQYYGLAGGGTLFFLELAPDGSTIIEVQKLEWSDGLFDVTWSGTTESAAACGAGDGAIIVWRVGCSAPLRVLRAHTSEVCSVDWPRTHLLSASWDTTIKLWDPESEACLSTFVGHSQLVYTAAFSPHSPATFASVSGDGHLKLWTCTEPSRPAAVVKAHDAEVLSCDWSRTETHALATAGSDGLIRGWDLRRLTSPMFTLKGCECAVRRVQFSPHAPSILAAGSYDFTTRIWDLKRGCEPLETIRHHSEFTYGLDWNALRPHQIADCGWDSLVHVFTPRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT21</accession>
    <name>A0A835GT21_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT21"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054167">
        <property type="entry name" value="Tor_FN3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049336">
        <property type="entry name" value="Tor_FN3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054166">
        <property type="entry name" value="Tor_FN3_3nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF620">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TORSO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23008">
        <property type="entry name" value="FN3_Tor_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23006">
        <property type="entry name" value="Tor_FN3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21468">
        <property type="entry name" value="Tor_FN3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032478117" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="367"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="709" mass="82145" checksum="32AEDB423FC1731F" modified="2021-09-29" version="1">MYYKMFERYIALCLLKHITLTLYVSGKPTGGENSKIFTDFQLKDLALDVCTQLELFLNVTIDSCLESYWAPEQSMPQLSPHVRIRCWRNESIWFQIEPSENFQLVALVPDPNNASIYIKHSIIEPWSEFEEIAVTPQVNYTLWSTELKEGSPIMWRRGETFPRHDVVQVNKTYVIKKDFHPNEDPSVLDGRFTWNTNGDADLCFDVVNSCEKSHLVHKKVWPNSKEPYVVFDKLPVEDDCIIHVIGLYGTTKLTYQTPSCYQDNCVPPEIQPEMPDNITIAAIEDLFDSWEVHVSWAKPELLPDSYRDATETVFRNVTSNKKWGFFNVEIKSKLGNKTATTSREAQFLAGRQTVERRRHRCARSMERDRRPVGGAGRQARVTRSHWRRSIRCRTQGHARAALMLVAVKMLKDFPSLEEIRSFRSEMELMKSVGVHPHLVSLVGCCTGRRPLIIAEYCSRGDLLSYLRCTWDVMLSKRNAKYYNNNIDVSDYRNDLFKCKAQMESSKLVVNKLYELQEICDKELTALDLLSFCRQIAMGMEFLAANRVVHRDLAARNILVTADRTLKIADFGLSRDVYEENQYKQKGNGKMPIRWMALESLTRRIYTTQSDVYDIMLSCWRTHPRDRPTFADLHHRLDELLNSACANQYLSLEIDADDAPPTPKHHRYIKMLMRGKRAWSRGETYERPLKAPQSNHYTSPPDSFSTQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT47</accession>
    <name>A0A835GT47_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT47"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032870766" description="DUF4773 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="266" mass="28949" checksum="C8E3A904BAA76FB9" modified="2021-09-29" version="1">MSVKLTLSLVFAVLAVAHCANILDFLNLDEAKKLIEPAAPELREDLPSCKWKCKGPACACCIDKNVTAYDPEGAKCIHMRYLSKDEGFFVQISHGKKVDYEKIQPSNPEPLCLVLGVFFQMCATFNKMAVTADGLQGCVNLEPGTIFVSQRKIPLGCFKANESLMEMSDPPKETAVEAEAVEASTDDNTEDSEDVEFDPNKFFAGVYQTAQQSIALLSSLLETPISNSTSVKPASSTESSSAPPPENPTESSQRRGPKNLKHPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTJ5</accession>
    <name>A0A835GTJ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_001218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTJ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="696"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="209"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9423409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="742" mass="84496" checksum="2B0D3DDEBD5EF728" modified="2021-09-29" version="1">MILLNFTQIRLLTLGNYLKRMGRKNRQFNKFAQRKRERKEQEKNPQEKPAADTRKHYEDIVRENAAFEEYYKNQKVCPEEEWDTFMKTLKENLPTAFRITGSKCEAAALMKIVQSQYFSEILNMKLQVEGDGEQGEEIKPINLPWYPGGYAWQLRLSRTDIRRNEALYKLHNFLVAETAAGGVSRQETVSMIPPVVLDVQPHHKVLDMCAAPGSKTAQLIEFLHAEEDKMPTGFVMANDVDNSRCYMLVHQAKRLNSPCILITNHDSAVMPALEVTNEQNPGSTKPLKFDRILCDVPCSGDATLRKNPDIWLKWSTGNGNNLHGIQYRVLKRGCELLEIGGRLVYSTCSFNPVENEAVVHRVLQETAGTVQLVDVTNMLPGLKFHKGMTYWRPASKDMVFYEKYEDVPEKWQTVVRPQMFPPKPEDLPKYNLDRCIRILPHHQDTGGFFVAVFEKVSPLPWEKDIKPAESAEVKEEEKKEPPKKKRRMGGYREDPFVFFSGEEEDVYPSIKEFYDLKQDFNATCLLTRCHVGKKKNIYLVSPIVKDVVSLNEGKIKIINTGVKTFVRCDNKNMVCPFRLSQEGLQSITQFIGPKRRLRILKEDLILVLQNDNPSKPPDVKLFTPQTQELVKDFATGSCVLEYKEEGEDTNLELTLVGWRGVHSLRAYTATPDTVHYLRLLGADYSKYDVNKFKKASDVPDTDAEANDVTEATEATESTSAAADSSETNGAGADVEMVEQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTT1</accession>
    <name>A0A835GTT1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="112" mass="12491" checksum="A3E12E3BEA520F0A" modified="2021-09-29" version="1">MTFVILACALPQYKLWWPFFVVLFYVLSPIPTMIARRHTDSAGGNSPCMETAVFITMGFLVSSFALPIVLARAGVIELGACYLTLAGNVIVYLTILGFFTIFDMDDSDYTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU13</accession>
    <name>A0A835GU13_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU13"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18487">
        <property type="entry name" value="BACK_BTBD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18281">
        <property type="entry name" value="BTB_POZ_BTBD1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000037">
        <property type="entry name" value="BTB (POZ) domain containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="564"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="935" mass="103867" checksum="2187BEB7063B9476" modified="2021-09-29" version="1">MASGSKNDIVNRLLNIRLDDGGGGDEPPPQNMLPSNQQARQLVQIQEEENGEVSEPPASSAAIENPQPINNTGGRLHNWQATKTTVKDRLSYLFNNEILSDVHFIVGKDASQQVIPAHKFVLSMGSAVFDAMFNGVLATKSDEVELPDVEPAAFLHLLKFLYSDEVQIGPESVMTTLYTAKKYAVAALEEHCVDFLKSNLGTDNAFLLLTQARLFDEPQLAALCLEIIDKNTADALNAEGFTDIDQDTLNAVLERDTLRIREAKIFSAVIRWSEAECIRRQLPVTPSNQRMVLGRAFNAIRFPLMSVKEFAMGPAQSGLLDDREIVQLFLYFTVNPKPNVGFLDAPRCCMTGEELTVNRFPQTDSRWGYCGTTDRIRFTVDQRIFVVGFGLYGSYYGPTEYEVHLQIIHLATKKVCGSNTTTLCCDGTDDTFRAMFKEPVEILPNTSYIASAKLKGTDSYYGTKGLRWVTVDCNNGEKVVFQFSYAADEPPPPQNMLPSNQQARQLVQIQEEDNGEVNEPSSSSAAVENPQPINNTGGRLHNWQATKTTVKERLSFLFNNEILSDVHFIVGKDANQQVIPAHKFVLSVGSAVFDAMFNGVLATKSDEVELPDVEPAAFLHLLKFLYSDEVQIGPESVMTTLYTAKKYAVAALEEHCVDFLKSNLGMDNAFLLLTQARLFDEPQLASLCLEMIDKNTADALNAEGFTDIDQDTLNAVLERMVLGRAFNAIRFPLMSVEEFAMGPAQSGLLDDREIVQLFLYFTVNPKPNVGFLDTPRCCMTGKELTVNRFPQTESRWGYSGPTDRIRFTVDQRIFVVGFGLYGSYFGPTEYEVHLQIIHLATKKVCGSNTTTFCCDGTDDTFRAMFKEPVEILPNTSYIASAKLKGTDSYYGTKGLRRVTVDCNNGEKVVFQFSYAAGNNGTSVEDGQIPAIIFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVF8</accession>
    <name>A0A835GVF8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="9087" checksum="18F673CFABE16FED" modified="2021-09-29" version="1">MMFSQYSRGRGYRDWRTRGDPTLINSLWRSRQPLGIRKQLGNAEVYIILALLIGFVTVVVGCWLSDNCWSPEPEDVLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY35</accession>
    <name>A0A835KY35_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000806">
        <property type="protein sequence ID" value="KAF9405122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY35"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="198" mass="22355" checksum="E95F3A9598A8B08C" modified="2021-09-29" version="1">MRSKFKCGASTFTSCSVQRHLAVAGKVLSQYTVVGCCTSTSEHNVSIVDSQNYNQIAKLSRCVVENISQTDTHMYRLLLTLLSITLLNIAVEQVFTQGITKEHQGLQAYGGHLKSPVVGTITTPNFPNPFPVPVKCKWIIEHDIVNGTISIYFTQQYTTSRLTFTEYMYYDESYKLGERRALTLTDENITRIKWLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYM7</accession>
    <name>A0A835KYM7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_013458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000652">
        <property type="protein sequence ID" value="KAF9406011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF274">
        <property type="entry name" value="ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1232"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1269"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="558"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9406011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1605" mass="179797" checksum="168FB421FCFAE275" modified="2021-09-29" version="1">MAKWKCGEKEGDLDCVAIGSRLRGAMGTRRPAKFWPQLWATVVRNLLLKKRDTRKTLAFLNNMSSTPQEVLVPLYSLGVLIFLKMLVPNPNFPEVRKPGRLLRIHHDAFPENHSVAVVADWLNANGTMGFLEEINTLLAESHQHPIRWIKYNNNSELNDAYHNDARNFPIAVIFHTDPTSNIEPLRYTIRTNPSHIGTPSTRILTTSPAKCRERTASKDWSSDWSRGGQLIPLSEMHGEDTCPVLQYYYSGFLALQTLIDYIKIKFDTDAAIPPPRIDLRQFPKRQHTGDWLVIFRVIMPMYMVMTLSQFITYLLMFVVGEKEKKIREGMRIMGLKESVYWGSWFLIYAVFVTILSIVSTVLLFTLKVFQHSSYILIFLLMLLFGFTIITFAFMLTPFFDRARTAGILGSFAVNLMSGLYFIQVFVSNADSLAFWFVSLISSSCYALAMDKALVLDMAGVGVTWDNLWSGPGVPFGGSLIMMAIDTVLYGLAAYWLDAVIPSEYGIKQKPWFCLFPSFWFGSRRARVSAVHFHSNGEAAAHNKDIEPVPRELQDKEAIRIVGLQKSFRHCRKPEIKAIDNIDLSIYEGQITAVLGHNGAGKSTLFNILTGLTAPTNGTAYVYGLDVRDPNDMHEIRQMIGVCPQQDVLFDLLSVKEHLQFFGAVKGIPRKRLPEEIHKALSDVGLLDQMNVFAKHLSGGQKRKLSIAIAFIGDPKIIILDEPTAGVDPVSRRQTWRILQRARHGKVLLLTTHFMDEADILGDRKAVISKGRVRCAGTSLFLKNKFGIGYHLTLVLDGVCREHQITRLVRGHVPRAEKARRHGRELSYILPHYAVHLFPPLFNAIEQEVKEKTNRLGITSYGVSMTTLEEVFLSLEGENAEETEAVEGVSSVKLVRARALSRSLSLQSKTLSYQELNDKDGQKATSLPTPPASHALHSTTHGVEHVKVAPEVPISVDALGETVKTNPTCWRTFCALVYIRMVRMIRDPYKLWVMILMPIISCALGLYMKSRQIVFFRMQPLKLDPNAYLNKTPIAVYSEQDNIKEITDLRDSLESLGAFPIIDFDGNFSSLLSMENFGAFSLRDSLIPYGKIMAYYNSTYTHSLPIIVNLLDNSVYKVLMSASGLMESYKPIEVLTHPFQQTEQQEEFNLGNVVCAIFMGMIFALVPVTLAVDIVYDREIKAKNQLRVNGLSMSMYFLTYFTVLIFIMILTSVGVLVLVILNDIPSLTNGSAITMLSGLLLLYSPSAILFNTCLSYIFDKMDSAQSIMPNITTWVGVIPFILVAVLDTFKWGSDIAFYLHLTFSFLDVMYIPYAIIYYVDRVYLTCNLRDLCTTPPLSSYFTAEVWVLLVAMLFHVPLSGAALLAADRVKSGGRICPNLRKEYKVRGTGSGGSCWSQKEETSSRVKSRFVGLARLSLAVEGGEVFGLLGHNGAGKTTTMKIITAEERPTHGSVMLGSQNIDDSQTSAFMMLGYCPQHDALWKNVTIREHIECYAAIRGVSKADTPRIVDAYLNGLQIMEHANKNADECSGGTRRKLSFALAMVGSPRVVLLDEPSTGMDPRSKRFLWDTILASFQGKKGAILTTHSMEEADALCSRVGIMVKGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYR3</accession>
    <name>A0A835KYR3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="8">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KATNA1</name>
        <name evidence="12" type="ORF">HW555_011556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Microtubule organizing center</location>
            <location evidence="8">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle pole</location>
        </subcellularLocation>
        <text evidence="8">Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000353">
        <property type="protein sequence ID" value="KAF9408913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYR3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19522">
        <property type="entry name" value="RecA-like_KTNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000025">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048612">
        <property type="entry name" value="KTNA1_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="236"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="244"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="484" mass="54680" checksum="B0FC4A7E802F0A32" modified="2021-09-29" version="1">MMMIFYHQVQKQMAREYEQLKATVATLQMFQHEGEKAITPLAGNYEDLPTRDQMWAPAPHELDPDIWPPPPDRDPNAWPPPTSVEHKGPPAMKSARANPRTARNDNKKTTPANRNATSSQRKTSDVRNPKNATNKAHSAKTKDTSNKEHSNKDKQDRDNNNGDTDDEKHKEEERRFEPPSAADGDLVDMLERDIVQKNPNIRWDDIADLAEAKRLLEEAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDSLCSRRGSDSEHEASRRVKSELLVQMDGLGSATDEPAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPTQEGREALLAINLREVKLDPEVDLRAIAKKLEGYSGADITNVCRDASMMSMRRKIAGLKPEQIKQLAKEELDLPVTKQDFMEALAKCNKSVSKGDIQKYLSWMAEFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ03</accession>
    <name>A0A835KZ03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000955">
        <property type="protein sequence ID" value="KAF9404520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="888" mass="100949" checksum="766F48043D204311" modified="2021-09-29" version="1" fragment="single">RQSEIISSITTIKVNFNKDSDSRKNAEYIKKRLGALDALWEEFEQNHSRISDHASEADEYFRLNTYQVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQRTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKLHRYNNEQALFTHQIEIFLNQPNIQKQSSSEIKRLYDTTTECIHAIHNLGVNTNAWDPLLVHLLCKKLDTDTQTDYREARVEPRKLPKLDELMTFLEGFNHRNYQAQAIHISKCALHNQIFVKIAYSLTTEMNVLPPNVASLAKAIIIPYSMKRPNANHVAVDDEELLLTTLSINVRCSDGTYITLRALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQSKGLVSIDCQSIYGDYNFTTEALVLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLLDSIIVQLEQEISEIEHYDMLLKNTNEAPMRLRRGLVNGVGYIANSLFGVLDERFAEKYKSDIEQISHNEKHLQNLIKNQTSIMESEFNILRRNENVMNKQFSFINQRLQDLAREVYEVRLVNQDNNYITSSSLAASIILSNLRWIQQTLIGTVTDISHGRIDSHLLSPEQLSYQLSIISSQLNGKLTIPVDIKNIKDLYRLLKVSARKQGQHYYQFLTSVSFIAYNLHKDTAFLLSEEDLKSCTHIPSDILLCSLNMPIYDLKMKQSICDIKIINHAHLCNNLNIHHHIEVPEVSMLNRIMKTSIPDNISMVEDHQVIWDQLRAQIDEVKEQSSTDLSIHDVHHYTVLYISVAAVIILGGVVVYLIRSRRAAARAAASPAPRPGGCWAGPATVAPVDPAPVASHQARSVLKCSEVFTLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ93</accession>
    <name>A0A835KZ93_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="277" mass="31074" checksum="1A9F92D454954C96" modified="2021-09-29" version="1">MTSPQSACYGDDAVSYVQVKRDDCLASHGGCKHAIAFLMWAHRRSKERRASEPSCTLMEICLKGSPVPPGDSAVLKKFLDEARKRKIEDCQLLRYQPTCCPIETHALLLCINLYLNLKTKVWKKDETQGQSDSPLWFELRYGRVTASRAFDVSRCNTSDGTLISLILGGKIPDTLSMKRGRVLEDEVRKIVELKLRKRIIRKCGSYGNGAGGSQQRTRAPAAPARPKLVERAGGRRQQQCNAFGGAHDTSDCRFRRYVSRVCNKEGHLRRMCPNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZG2</accession>
    <name>A0A835KZG2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000733">
        <property type="protein sequence ID" value="KAF9405477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZG2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="18495" checksum="A0261B009EDFB2F6" modified="2021-09-29" version="1">MPPINTFVFFDFGTLRNQDLDTCDSVTDLCLQAIPRQQYLEPTNTNAPRNGKIYLKFPTHRIRIEDFNVINNFINKQEKPVCLFAHNGNRFDFAIMKRHFENINVSLADDVLVADSMYAFYDILEDRRQGEAVREIYFKGILHQLMHIHFMMSTGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZV6</accession>
    <name>A0A835KZV6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
        <name evidence="13" type="ORF">HW555_013362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000630">
        <property type="protein sequence ID" value="KAF9406179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZV6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9406179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="15142" checksum="35980187BF94552E" modified="2021-09-29" version="1">MLPLSLLRTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEVIDMVKSRSRSEVSKGRGGGQNMRTGRGGNRGAFGNRGRPAPLARGGGNQGRNPQQNKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZZ0</accession>
    <name>A0A835KZZ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000342">
        <property type="protein sequence ID" value="KAF9409073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="49"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="721" mass="82487" checksum="EBEC193C29C1E9A7" modified="2021-09-29" version="1">MEDYARNGHLGDMECGEGVQVVKLGEGERRYELDEEALRRVLLREDVRGLPVVVVSVAGAYRGGKSFILDFFLRYLNAPRSSQVNGEWLGSEDEPLKGFHWRGGGDRDTTGINLWSKPIISTLPNGEKVAVVLMDTQGTFDSETTIGQNSTIFALSTLISSVQIYNLSGNIKEDDLQHLQLFTEYGKLACAIDTESKPFQTLLFLVRDWPNAFEHPYGFHGGSTLLNKRLQTNTKQKTELREVREHIRSCFDKVICCLMPHPGLTVNNQFFAGCLRDLTPDFRRTLLELVPSLFEPTRLIPKMVTGQVIQCQDLFDYFQKYLNIFNSDDLPEAVTILKHMEARVRDGVSVSSATLTAWHEAARDLALKRFTEKKKLAAQADVDAHLDALKMELVACQSQHNRDNEFKVQDTMSLAKIAYEAAVSRVSAEHARLCLHPRDMDDLHAEGLRQALEIFDAARDVPQGEEDIKKTNLLENLEQLHENLSLINNRNNLNAVWEGRDVYVRRMKLDMDHTGVSSERLNSQHQDALKKAKTAFYSMRSLTALSMKTTCFLNVFYNFMDLDKANEYSNMVAMQAAENSYNNIITAAWGPQTCCFHPRALEDLHKQAVNDVMAQILAKRPERDTTEFKTAIFENRYKELKKINVYYNEQAVDYAVLTYESKRKYLNVPLFGFFNKLITKDEDAKRQAIKEFMNRRRGTDYNNDPFYDDLLRKIEKVNNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L162</accession>
    <name>A0A835L162_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010836</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000288">
        <property type="protein sequence ID" value="KAF9409945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L162"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9409945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="52329" checksum="12F268058EB441C9" modified="2021-09-29" version="1">MPKGRSTIPAGLLRHLWHFIKHINEVSFEHGGAIEFWLGAQRFYVLSDPEDCLTLANTCYSKPYIYDFAKDFLNNGLITAEAPVWKSHRKLLNPAFNQQVLNTFVDEMNKQARNLVSNLSNELGKKPFDIRHYLVNFTLSTVSRTSLGLTAKEQKIIDREYAEAIEDLLALYCDRAQKVWLHVGCVFKWSEMKRRQDRLTKTLKNIINPVILKRKSEMATKQETTRYEDAPGKFKPVLDHMLQMAHEQNVFSDEDIREHLDTLVAASYDTTSSAMTFMLLVIASYPEIQNRIYNEIQEVLQNKDDDFSKHDLQKLVYLDAVVKESMRVHTAVPFMARKVDVDVKLKNCTLRANSTCVIGAHALHRHPLWGPDAKEFKPERWLNPSTLPDNPVVFAAFGVGKRNCIGKLFSILMMKTALAHIVRQYHISGDIHNIECEFDVVVKPVTGHHIGLKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1I5</accession>
    <name>A0A835L1I5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000263">
        <property type="protein sequence ID" value="KAF9410435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1I5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="152"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="369" mass="41952" checksum="C9422BBF0C4CEA8A" modified="2021-09-29" version="1" fragment="single">RETSPAAGVGRGARAQVSLYCRLIHFSVQPRAQAATPRDTIIVQQPHNDYGRALKNPKLFIYNLPRLAEHPFHPILKPTNNLILTAASSQFYKLVCAIRDAVAGNRNEDDVVLPPFDPEKNDNGAENWCNNIDTVAKDRGWSSITTVSKAVTDRGTNFTSEPVRSFLRDMQINHHMIATGTPRSNGQAEKYVGTIINMLTTTVNDSSEWPSVLWKIQLSLNTTMQKSTGFSPTRLLIGCNGNIPPIQARLDEIQDNDYIQNNDSEADRDLARQNLRETAEKYKKRFDTTRRNNLVFKKGDIVYVNQNHRRHDKLSPKFKGPYEVIDILEHDRFSLKGLNTLRNIIVAKEKLKLWPGEWVEQNSSFEEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L213</accession>
    <name>A0A835L213_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L213"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033061440" description="phospholipase A2" evidence="9">
        <location>
            <begin position="29"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="10">
        <location>
            <begin position="414"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9411227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="471" mass="52565" checksum="57E34BDA1546C4EB" modified="2021-09-29" version="1">MYHRRRKKMRQFIISALLLLSWPAFSHTKSIISTQTPTKYGEDNIDNSIIDFDEEFSLKYNKKYGMIPWNSNEHFNKESHRYTIVKDFDKKVDSNRNRTETKLDATSTTDYSVIPLELLSTTENAFVSIFESTIEPDLTVIPLSTTRKTPKLIIEQTVTLPSSTPETESSTYYSDDETTTVTETPITERYTNKQEDSETTTPAYDTTTDITEQSTSYPYTNATEVNLETSTITVSNTTKSANLSRVDLSSEEEDSDVPIFTELDTEVQEEVPEDYYDSKDVVPTTVPKTDALSVIFGLAGSVVESVVESVAERVVPKGIVDLFRRMQRQSEMLEAERLRSREENGGIGQFGRGILKTISSGISKPLSQLMAGARDIGSLDNDRGFVSSLASGVTSVANVANSLVDSFKDRVQAIYPGTVWCGDGRSATARSSDLGLFFFTDTCCRQHDACKLYIKAGETKYGLTNTGLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2E0</accession>
    <name>A0A835L2E0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000669">
        <property type="protein sequence ID" value="KAF9405865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2E0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="369" mass="40917" checksum="E6381C39E362B54A" modified="2021-09-29" version="1" fragment="single">FPTVGLSSVLFPGALGNFKSSESSASIEQDRIPKCWRALVKTVCRVLVRNSFTEYVEPLKPALALQTEAFKSKLLNRTNELPAVLLLRLDKTLENKCLSSMPRLHVINPSGTLIYLASQQTNSRKERNSSATLATVSLAWPADCIWASTSFILLVTDSWTDSWILTRSLYSDIVLFVKCCMMSADMLAGGAQLMKKKVKSMQASMTPKFRSKDIQSKIKALNQASSPLKPSITSIKTIKKICTSESNINKVTRNILTEEEQSDNDIYVAPVASCSSSSSVHSLQLKSSFACSELVAAEKALINTIKKIENNPRLYLGVPNSCYFLIDLLKDDYGISPSNLSKIFIKNIPLIAKFLRPFVVELDKDMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2K1</accession>
    <name>A0A835L2K1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2K1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="8814" checksum="2D64572EA4A665EA" modified="2021-09-29" version="1">MSIFRDNHFGCALFVLTFIYAICAVSSFALETGSGRCGRNVRAASDERGERLLLLDHAAHSSLLSAAQLNKLNSGTRTHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2W7</accession>
    <name>A0A835L2W7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000155">
        <property type="protein sequence ID" value="KAF9413561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2W7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="138" mass="15513" checksum="64DD26EA71AD9148" modified="2021-09-29" version="1">MKYNKGISLTEAYSVKVSGKVELGSRLSKVFKDLYQQLVEEDVYPKDPNSDEGGSKIPAMSVGNIENSDSCEDSNSYVDEPKKIKKLKKQKHHNMHESHSAQDKTLKSGLEALHLYGYHKSPNKVDNDRGKPLNNVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L307</accession>
    <name>A0A835L307_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Large neutral amino acids transporter small subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_012977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000552">
        <property type="protein sequence ID" value="KAF9406756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L307"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9406756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="53234" checksum="7639CF5280B0D7DD" modified="2021-09-29" version="1">MPKLSPKSKEECETEALKSDVEGDPEAKEGGAGALEAKMSLMNGITVIVGSIIGSGIFVSPTGVLKYTGSVNASLLVWIASGVFSMVGAYCYAELGTMIRLSGADYAYIMETFGPFAAFIRLWIECMIVRPCSQAIVALTFSVYVLKPIFPECDPPEDATRLLAACCILLLTFVNCWSVRAATRVQDWFTYAKLLALFIIIAAGIYQLCRGEVQHFTFEGTTNDVTSIALSFYSGLFAYNGWNYLNFIIEELKDPVRNLPRAIAISCTLVTVVYTFTNVAFYTTLSPTEVLGSAAVAVTFAERLFGWFALSIPLFVAASTFGAVNGVLLTSSRLFYAGAAQGQMPEMLTMVSARATPAAAVLAVALLSLVYLTVSDIYALINYVGFATWLSIGAAVLCLPVLRYTQPNLERPIKVNLFFPVIYIICTILVVAFPAFASPAETGVGCLMILTAVPVYLLLLHPRTRIKCLGSITNVATVLVQKLTLSSRPKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L349</accession>
    <name>A0A835L349_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000147">
        <property type="protein sequence ID" value="KAF9413929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L349"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF61">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="818" mass="93726" checksum="E83FF842830FF436" modified="2021-09-29" version="1">MGAMFRSEEMVLCQLFVQPEAAYVSMYELGEAGIAQFRDLNPHVNDFQRRYVSEVRRCSEMERKLRWVAGELPEPPPPPKPERCSLSPREINILEERIDFIESEIQEITRNARNLKSDYLALIELRTLIEKMQTFFQDHSAQRKISASVQIYNNDAVLGHLGFISGVVTTARVPAFEKMLWRISHGNIFFKQAQIDEPLKDPITGHELQKTVFVVFFHGEQIKLRVKKVCHGFKATLYPCPATYKDQLDMLAGVGTRIKDLEMVLEQTENHRRLVLTNIARDISTWMVAVRKEKAIYHTLNMFSMDIVKKCLIAECWVPRKDLTAVQKALENGVKASGSPIPSILHYVPTNEIPPTFNRTNKFTRGFQNLIDSYGIASYREVNPALYTIITFPFLFAVMFGDVGHGIIMTAFAAILVIYEKRFLKIKTDNEIWNIFFGGRYIILLMGIFSIYTGLIYNDMFSKSLNIFGTSWRNVYEDGVLRNHTMLELDPKTAYTQTPYPFGLDPAWQFASNNIIFLNSFKMKLSIIFGVIHMAFGVTMSVVNFNFFRKPEMIFLQYIPQILFLLLLFWYLCLLMFMKWIMYSAVSEDPSLGTSCAPSVLIIFINMMLMKSSEDKPPCRAMMYAGQNEVQRTFLAIAFLCIPIMLFGKPIYKAFLAKKRKQYQQGVETGEVTEKEGHDGGLAEELITQCIHTIEYVLGAVSHTASYLRLWALSLAHAQLSAVLWQRVLVMGMGPPGVTSIKLYIIFAVWAFFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGQGYAFAPFSFTDILENEEDDHKPVMETNGGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3R7</accession>
    <name>A0A835L3R7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="137" mass="15546" checksum="03594657785186E4" modified="2021-09-29" version="1">MGQYCKMSQYRINESWIIQHLKKKDASPLDLVLVHHFHPHQHQCKACAARLELRNGGNFSKMDAALLGAGPLCNKIICRYNSMTAELVRTRLNNKAGPNLAAHVRDCTHVRVRESPSSRDESPKRGDWESESPKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6D7</accession>
    <name>A0A835L6D7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6D7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="23404" checksum="B559E5D01C462DA4" modified="2021-09-29" version="1">MYTMDSEIAAMDSGLSHITEKASRQEVKSNDAKPRCIWLRLRLVRETKVWMTKHSLETGTNFTPTDILVTKEQEEVMLGFRRIFGFKNVIGIHIDCTHIKIKKVGEEEYNKSHILTRNTIERCFGVWKQRFRCLLHGFSVSLENAKLYIVALAVLHNFATKMGEKLEIVENIPHVPRQPLQNMPEDRTGHTARQLFIRTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7T0</accession>
    <name>A0A835L7T0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7T0"/>
    <dbReference type="OrthoDB" id="7402155at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032401962" evidence="3">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="434" mass="50679" checksum="E206A864249EDED4" modified="2021-09-29" version="1">MLTLLIVLAAVISALHLRTLIMSTEDRHILNKQEVNGAVWGISKLWNSAMEQYGEPIAHYCVSVGYSIYLRLTFINVMIFLLKYVPTGFYMYKFIRDMYVTSRERIKQKQNEIEDIQLQIQIVNTKLCVRDAEFAERAEQLRRGAEKLRRVRARVREVIAADDTVRRAIDNAVIWDADNDLHMHCAPHEEDREFMMELLKELKYDHMVNPERQSEKKECGERAPTDPTTPDNSVYSSLSDADVRQDCRVKILKVTNVYKVAYLKHYIKQKRLRRATKQAMLKKKMESIKKLLEDWQKTLNMVINSKLTILNLDPHPMDVASQEAMGDYSKPHNSSDSDSDFRNSCTDVRYDEYSLSWAENPYKPYAYNYEDVAEANRDYYDTQDFGDVKPMFSCERGKMPNMMSIIEETNSQIAIEEIKSECGDDYECRDLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8A0</accession>
    <name>A0A835L8A0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="167"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="361" mass="41655" checksum="6F9B60B8DD886075" modified="2021-09-29" version="1">MESMDVAQEGTSAASTPAGENGPDKNVTAEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNAMYHNKHLFKGKTVLDIGCGTGILSMFAAKAGAAKVIAIECSNIVDHARKIIEANRLSDVIEIVKGKVEEVELPVEKVDIIISEWMGYCLFYESMLDTVLYARDKCTLFICGIEDRQYKDEKINWWDDVYGFDMSSIRKVAISEPLVDVVDAKQASLKLIKRSKSRIAGARVVTNSCLLKEIDLYTVKKEDLNFESKFHLQVRRNDFIQALVTFFNVEFTKSHKRLGFSTAPEAPYTHWKQTVFYFDDYMTVKKFEEITGTFSMHQNARNNRDLDFEIEIDFKGELCQVREKNHYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8B7</accession>
    <name>A0A835L8B7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="184" mass="21838" checksum="0BC5EF78F920CE54" modified="2021-09-29" version="1">MTVAVSGLCSCHNKHSSHGDNKVHNQHEVMHNHHGQLFNQYRPLYNPHGLMQNQHGQIHNQRGQMHNRHRPLYNQYGQGHYQYGLSHNQHGQARNQYGQKHNQHGHKPPHNPYANHRLGWLLKDMDHKPVHEDQDEGPSPLFQPRSFYRHSGYQHYDSRDSHDRYYAPINNTNSLMMPHHNLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L981</accession>
    <name>A0A835L981_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_016322</name>
        <name evidence="6" type="ORF">HW555_007144</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in calcium binding and microtubule stabilization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000117">
        <property type="protein sequence ID" value="KAF9415110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000650">
        <property type="protein sequence ID" value="KAH9633588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L981"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9633588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="172" mass="19766" checksum="1E8D818E92CE88A1" modified="2021-09-29" version="1">MRIYKDIITGDEMFSDTYKIKLVDEVIYEVTGKLVTRSQGDIKIEGFNPSAEEADEGTDAAVESGVDIVLNHRLVETYAFGDKKSYTLYLKDYMKKLVAKLEEKAPDQVDVFKTNMNKVMKDILGRFKELQFFTGESMDCDGMVAMMEYRDVDGTQVPIMMFFKHGLEEEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9D5</accession>
    <name>A0A835L9D5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9D5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000007">
        <property type="entry name" value="Peroxidase mlt-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF86">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="1021"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1273" mass="146625" checksum="655C423A74B60F5B" modified="2021-09-29" version="1">MSRRTCTKSWRGHLSGADSKQDICMHFAAFNMRAIASSRHLQIWTERQFSSLTKMDKLIILFLFVFICSVLGEATYYSSYYGLPLTASQVAAYTSNGTVANCTISVEACDETEARRIDGTCNNLNYPSYGGTRTPYYRILDASYHKKSSSEFEPRLSASGTELNLTRKIRTSIWAEGRVDDEVLTSIINHMAVFFATDITNTRDTTNYVTWRPYCCKSAGKNDYACTPNHVPKDDFVHRFSGIRCLNMTRPLTFQTSGCAPNTTTPLRIVDATPLVDLSPVYGNTIEKARRTNSGGKLVTVTVNDRINFPDTSSLNLLLGINFVGIILFWNNHNFIADKLAEVNPCWTDDQLFNTAREINIAYGVQMFYYELMATLMGKENLIADGILSEDEGFRDLYDDTKLPQIALEYPVVLRWMHSLQDGDLRMYYTNGTYKSTFPIVDLTSNTDFLKVNDTMDYVTQGFFRQPTANSNDYIADPDIVQRGLGRLQRSNDIMTNDLAKNRYFGFKGYTEYRNHCFGDSITSFDDLSDIIDVERVTQLKQLYKDVTDIDLLAGIWVEKKKENSHVPPTFYCLVKEQLERSIVSDRHWYERESRPNAFTADQLAQIRKVSLARMLCDIGPGVTEIQPNAYELPTTGNEIKNVKMLKILLLSTCMCVGISNAILYDCFTGKPINRTLLRVYEEKNNLGNCTVEIEPCDPNEWRKVDGSCINLKHPSRGTQRTPLYRVLPPVFSVDYEPRKAVSGASLPLPRRLRTELLLMGQTTDLKITQLFSYYILFMISDVLSSHDIINYLQNITTCCTPEGKNDYRCTPIEVPINDPVHRYSGVRCLNLTRPQSFQTYRCLDNGTTFERIVFQTPLFDLSHIYEYRPGFINQLRTFENGLMKIEEDDGELFPPSDPDSNYCYQNQLPRETRCHKYQVNNVLGSNLWIILLYRHHNQIARELYRLNPSWDDKRLFYTARDINIAISVQIYFYELLPIIFGKKNMIREGLIGRGGFRDLYDENVEPRMSDEYFYGMRWFHMIQKTNMKLYDKYGHYVRSFPMVNGTARTGFFAVDNNMQHIIQGSFRQLGGKPGRTIDYDMADRLLGGILFSSDAPTSDLKKGRYFGIQPYVNYKEFCTNRKYTSFADLKDSFRCEHLNRLKEVYQDPKDIELMAALWLEKPVKGGNIPETLYCLLTEQYKRTIKSDRHWYERPNRPHAFTKEQLKAIRKVKIAGVLCSIGDFVTEIQPHAFYAISNCNPLMKCNSSRIGKLDLTPWKESDYSKDTPLIIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC95</accession>
    <name>A0A835LC95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="108" mass="11796" checksum="51BD0CF9A8043118" modified="2021-09-29" version="1">MKELAARAREGKLQPQEFQGGTVTVSNLGMYGITMFNAIINPPQSLILACGGLQELVIPDKNEPQGFRLAKFVTFTASADHRVIDGAVGAQWMKAFKENMEDPANMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEK4</accession>
    <name>A0A835LEK4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="150" mass="16982" checksum="06F24E1BDE179E3B" modified="2021-09-29" version="1">MWRVLKTSDNNTPWEFISVLLSESTNFINAYIRINSSYCLVVLKLLISRQPTVSKGKLHAPSWKSDYSACALDTFRRNKTYVVYDSGVQTYLIGRSTMSMLRVALTYVCVSLSRTVKVVCLSYGIPMLPPPLRRLCGGRRVIEGKRSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGC6</accession>
    <name>A0A835LGC6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGC6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="40"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="33454" checksum="89864B03F2B79F81" modified="2021-09-29" version="1">MSRAVQRGRVPPTQPAGLALPGQYALANGDPSAGLNSHPYLSSYISLLLRAEPYPTSRYGQCVQPANVMGIDNICELAARLLFSAVEWARNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTGKILDSLFGEARLLLYRVAGAGGSVTNYGELLVLVRTHLDAYAEAARVQIQQPPAPAPSAASSGYYSTLDTSLGVNSSLSYGSFLSTPSRLPTNYTSSPRMPEASTSSPFKLWEGSGKLPRTDQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G135</accession>
    <name>A0A835G135_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001010">
        <property type="protein sequence ID" value="KAF9404345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G135"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008443">
        <property type="term" value="F:phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46566:SF1">
        <property type="entry name" value="1-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46566">
        <property type="entry name" value="1-PHOSPHOFRUCTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01134">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="485" mass="53090" checksum="C38C8622189F98E7" modified="2021-09-29" version="1">MLTEERHQAILRLLDQQSVVKSQELASLLNASESTIRRDLQELEDEKLLERIHGGAKRILNLGFEQDMIEKSSKNTQEKQLIGTLAAQYIQNGDVIYLDAGSTTLEMLPFLVKKDITVVTNSVHHAAKLGDLNIQTIILGGALKLSTKAITGSTGMDQLSHFRFNKVFMGMNGAHLEFGLTTPDPEEAALKRLAIAQAEEAYILVDQTKLNKVTFTKVTDLSDVTLLIDTCSPEIHAESTALGFLGGFTGDFISDWLKKEQIQTNFTPVREDTRINIKLKSETETEINGMGPAIRTKRNLSKISAGDIVILSGSTPATLRAGFYEELTQIIDDKQADFIIDTTGKDLFNALPKKPLLIKPNNHELAELFNVEFQTIEDILPFGKRLLADGAKHVIISMAGDGALLFTSEGIYRSNVLKRPLKNSVGAGDSMIAGFVGNFAKTSDPIEAFKWGVACGSATAFSDDLASAGLIEELIHEVKIEKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1T6</accession>
    <name>A0A835G1T6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000795">
        <property type="protein sequence ID" value="KAF9405173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1T6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="26385" checksum="84CE1E642AB699E3" modified="2021-09-29" version="1" fragment="single">VLCKRRPVTKGEGGKIVGGNDTTIQTYPYQAYLLLYDGRDYYQCGGSIISRYYIVTAAHCLASKIVFCRIQRIYVRIGSTNSNSGGLEYETAVFNSHPLYDDVTSDYDVGIVTVAQGMSLDGTNARTIDLVGYGSDVTDGETVVVTGWGATSEGGSTSETLMVTSVPAVERTRCNEILGGITTRMICAGFTEGGRDTCQGDSGGPAVTGNSLAGVTSFGYGCARPNSPGVYTRIGNVNVRFYIALMTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3G1</accession>
    <name>A0A835G3G1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Ribonuclease P protein subunit p29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_013309</name>
        <name evidence="11" type="ORF">HW555_013802</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000731">
        <property type="protein sequence ID" value="KAF9405488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000243">
        <property type="protein sequence ID" value="KAH9641327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3G1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9405488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9641327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="24244" checksum="7E5A7FC0E8BCE279" modified="2021-09-29" version="1">MSAEETFNKDAANAIVGFLKSNLSKSGQLTIESELKTDFVLAKKRSLSKKKKKPHKKRVRCLTRQEKKSIGFYIIPRNGVKYNDILPLHKIWLNYINDVLELDKHIPDRTSKSWETFTQTLFRADFHGSMLNVVRSKCPSYVGKCGICIMDTRNTFKIVSQDNVTTTIPKRECVFEIFLGKQKITIFGKNLCVRPAERSTKKIKGHIHPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3S6</accession>
    <name>A0A835G3S6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000430">
        <property type="protein sequence ID" value="KAF9407847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3S6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="8">
        <location>
            <begin position="107"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="672" mass="78520" checksum="FDA7073BE226DB12" modified="2021-09-29" version="1">MFHKTDSCFLQSRQRFFGNDDFQDELNNLFNKKFQFRFHNDWELPEKESWFSTPPWKVKQLEILKNRLNFHKSQLNDFNIEEWSSHTRRRNPAGEVCWKIRCLVNPEFLTQAWTKFYECACTYNIIPAEATLERKMVSLHLCEAPGAFITSLNHYLKSNHQNIEWKWVANTLNPYYEGNSPSNMISDDRFMFHTLNNWDFGVDNTGNLMDWENSQAIIRKAKSLGKVLLVTADGSIDCLQKPDAQEEVTSPLHYCEIITALQALSPGGTLIFKLFTLFEHSTVSLLYLVNHLFSEVNIYKPVTSRQGNSEVYAICLKYKGMASLEVYLPTLKSAYGTDVYGNFALFPLEAIPETFVKQVEECACYFCSIQCQVINNNLKAYLMQKNIALHRDIKKIRGIVATEFIWQYDLKPLDIEQEILKGILHEENKINMNPRYHRGSYTERQLYTKMSLREKLNNLNSFLQAEVLSNPLILINEQKINSSKFIFVPIFKLYQQILAEEEFKEIIFCKDGKNIDNDRDYGLEIHLRLMLPEYEHAESYHVFEKRCFKMLLQTLNKLAVGQTLLIQNISMLSHFNVSVMYIITKKCFEKIGFTSQNTIVLRNLMNKSALNYLEQVDSECDAVRGDGTKDVLNSLMVQTTNVGEFYNSIVFYNNTFYRNKCLEYLTKIEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G426</accession>
    <name>A0A835G426_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G426"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="245" mass="27862" checksum="93BB7DCDC6A516B7" modified="2021-09-29" version="1">MKAQVVAKSVEAKKLFEIYKYLAPKHSAQNSFSLAEPSTNPDEIPESMDCSMDVSDIVIHEDYEVFNQNIAFAPEMEICTSEPTITPEAIFEYQKENVPSDASVNNLDNILIKTTESEIPVSDLPYALSTTNDSSMDRTTKTLEVIFENQKENQPDEDASITPAYCIPSTSRQNVEFVGGEWVLVDITPNENLETQQIQTKLKDFLPIPKTPIKKHKQHVSKQNQTFVLTSKEWEDMELKKQQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G462</accession>
    <name>A0A835G462_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_014075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000845">
        <property type="protein sequence ID" value="KAF9404960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G462"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF1">
        <property type="entry name" value="NAD(P)H SULFUR OXIDOREDUCTASE (COA-DEPENDENT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9404960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="273" mass="30298" checksum="7E0ADEB1C7170DB7" modified="2021-09-29" version="1" fragment="single">MKENLMSKTKTVIVGANHAGIAAANTLLDTYPDQEVVMIDRNTNLSYLGCGTALWVGRQIESYEDLFYTNKEAFEAKGAQIYMETTVEKIDFNKKSVYCKKNNGEEFVETYDKLILATGSAPINPDIPGRNLKNVEFLKLFQDGQTVDAAMAKADVKTVAVIGAGYIGVEIAEAAKRRGKNVLLFDAAERCLPNYYDKWFTDDMDKVLSENGIELHYGELAKEYKGTDKVTAIITDKGEYTADLVINAIGFRPNNQLGKDHLTLFTNGAYLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4F1</accession>
    <name>A0A835G4F1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000605">
        <property type="protein sequence ID" value="KAF9406350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4F1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF3">
        <property type="entry name" value="LD12305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="31674" checksum="6884AA5360B39802" modified="2021-09-29" version="1">MARNTTLKQGKGARASVHPRADFLHIKRTLGANASVCDDSPRHTLLTKMKQLVLLALFAAAAQAQFLNGRILEPPVPSLCVQRTIHERYVDNKGYFFSWRDPALRGVEEDWLSARNYCRQRCMDLVSLETSDENEWIKARIVQDKQKYIWTSGRLCDFKGCNRPDLLPNEINGWFWTAELQKLAPTTNRQQNDWSEGGGIGKPQPDNRELIQGGAAEHCVAILNNFYNDGVHWHDVACHHRKPFVCEENDALLNTCDTPTPPSEFDPITTALHWYMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G558</accession>
    <name>A0A835G558_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000442">
        <property type="protein sequence ID" value="KAF9407722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G558"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF21">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9407722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="269" mass="32163" checksum="B65764CC5D139643" modified="2021-09-29" version="1">MGTLIRNITNYYHFVNDDLADPRTNSFPLVSNPLPIIIIMYLYHRFVRSWGPAYMAKREPYNLKNVIILYNIIQIGLSAYLTAQCLTRLYLSGYYSLWCQKIIYEDTPLERVVVSRVWLYYMIKVLDLLDTIFFVLRKKFNQVSFLHVYHHLGMCLLGFIGTKYVPGGHGIMLGFINSMVHAVMYSYYLISIVRPQWVRQWWKKYITQLQILQFIILILHFGHVLFEPSCEYPKWVSFMFLPHNIFILFLFSDFYIKEYILKKNKNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5N3</accession>
    <name>A0A835G5N3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear receptor corepressor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_012109</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000408">
        <property type="protein sequence ID" value="KAF9408087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5N3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031557">
        <property type="entry name" value="N-CoR_GPS2_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15784">
        <property type="entry name" value="GPS2_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="546"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="597"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="782"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="935"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9408087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139096" checksum="0FF0434276D9A508" modified="2021-09-29" version="1" fragment="single">VDREMALSESTLSKLKKKQEELEQTASKPARAEEPEETVPRHRSLAQCVYAENRKKISMDNKRQMQASSAHAVLSHLGPPVLYPLYNQPQDTEIYHENIRRHRTFRKRLAEHIRKLKLEAEKREDALAEAYSRRAADWLRRVERIEQGQKRKAKDARNREFFEKVFPELRKQREERERFNRLGARVKSEAELEEIADGLHEQEHEDKKMRSLTVVPPLLRDPSDTTPVYIDTNRRCMDMEAEHKELQLRNVWSQAERELFREKYLQHPKNFGQIASFLPRKSVRDCVRFYYLSKKAENYKQLLRKPRQRRSARNPPRAQPEPELPAGVTTRLQRSQAVSLGTTARTENKEQSMEESMPQVTDPVTCIPIPTAAPAQPPRSELTRTPPLPPSPPPASSAPTPVTSTPTPLSVAGSPAAAPTPPAVDVPLPPATTAEVTLTITPVSAVHYGLKEEAVGARVCEACHSRCVRSRYTRCPVPTCPGPKVSPKRLRHLPPRWHDLSLEQKRPLMEEFEIPSELSKCCFVCHKTITKRLEALVEGGSAPEPTEEEAARFRALLREHGTAWDRIAAVSGRTPASLKAFYFTYRRKLQLDTLVADRPASARCSSSEDSALSSADTDTASGGSPARAPPAQPAPAPRTDAVAPRRPRRDEYDSSATETADEENDAPSAKIVPPTSIPTAVSAATSCSPVTVVSSGTTTVPVVNRMTGAPQTVRDVVLNLIEISLTKDMPSQHPGIKHQIKVTSACASGREALATLSVVNSSHVGAAGAGGAASPQRAATITPVAHVAPSNDKDVYRNSTEYRPQQERESPNQYNSKPKTVGAPPRPQVKASPNPKGSITLGTPVETRFEPHRNPPEPKTGSITAGTPVHPHHLPDKRTLEFYKRRSPGGPGAYYAATSSQPRPQSPSFSPTGYTRNPYGPEQRQIIMADFITSQQMHSGARRDRERAASPQGARGIPAVPTTRCPISNTAPLPSTCLPTPASAAAARFMAQKFPLGSQFTLMMTVVFQQMMDRRVQSQPQYIERDRQLQMQRRDAIVFLLQQNLTNAADNYVVIKDIFLGILNECLVNFFLVDLLSNLHCLATFKNKFLINASYSVSSQDGERRMIQSVTYSTPGKPRAQTPHHIDRKDANRFTVGNSEGYVAGSAEEWKRRDAPKHAPYLEPVSPPDNHPANRNNSNRRYSCVGSSSVGVGVGVGSGVGGSGAGGGVLTAFDYVTNRIVEVMRSDADERAKPLAFPTTAYAYPYSALNVQAAGDGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5X3</accession>
    <name>A0A835G5X3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011152</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000314">
        <property type="protein sequence ID" value="KAF9409497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051460">
        <property type="term" value="P:negative regulation of corticotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="11">
        <location>
            <begin position="165"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="33575" checksum="87494017FC960749" modified="2021-09-29" version="1">MEKKSKDYGQRSSASALSRFSRIRRLSRPAHRIINPDEDCFLVTSEEGELFFKSPSNDPVVCGIYIIAEPDKRIEVIFNYLDVPCENGGLVAWVDGWELNGQVWPADSWDDDRVVESCDQRPSRKLVSRQNAALVQYRVPARGKGFAVTIRHLKNTKPCNVMLFGAEGVYTLRNHGETGNCSMLAVSPATVHVLDLNVGVTIKKGRVLEMETGTIHHCTKRGLSDYVDIGGANGLDHTKMEVQDSVCGLDSNEARRPAFIACEDTVVRLVSSGRYHNSVTLAFAPLPLEDIEHADLMCGLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G600</accession>
    <name>A0A835G600_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor eIF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein translation factor SUI1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_003313</name>
        <name evidence="8" type="ORF">HW555_011049</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000305">
        <property type="protein sequence ID" value="KAF9409652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000058">
        <property type="protein sequence ID" value="KAH9644983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G600"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000010">
        <property type="entry name" value="Protein translation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="7">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9644983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="110" mass="12452" checksum="9799C76115C38C8B" modified="2021-09-29" version="1">MSIQNLNTFDPFADAIKSLEDEVQDGLVHVRIQQRNGRKTLTTVQGLSAEYDLKKIVRACKKEFACNGTVVEHPEYGEVLQLQGDQRQNICEWLAKVGLVKPEQLKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G671</accession>
    <name>A0A835G671_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_010924</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JACKWZ010000297">
        <property type="protein sequence ID" value="KAF9409801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G671"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06370">
        <property type="entry name" value="PBP1_SAP_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000265">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000311">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032334630" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="529"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="901"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1090"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="838"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9409801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1259" mass="140197" checksum="9FC57C0022F8DAB4" modified="2021-09-29" version="1">MPLWHWCWGLLVLTVKYSYGEKFTLGYLTGSERRPGDYSYQRPGRVISGAISMAIDEVNEKLLGPMGHSLDFVVAETYGQEEVSIRQVAALWAANVSAFIGPQETCVHEGRMAAAFNLPMVSYYCRDVASSNKRVYSTFARTRPSDIDISRSVVAVLTHFNFMHVAFLYLKAPNHDFSRLANAIIAALREKQITVRPVQVYRQPYYYENRRENFSRNPFLDIVRETYKETRIYVSVGYYHDHIGLMLALDAMQLLDSGEYAAIGVDVEKYEAEEAIQYLSGPLQKEPGPRTLHAFRSYMAVAPSPSPSYLAFAREVNRRLQMPPFNFTNPLLALGGGKVIPVEAAWLHDAVWVYARALAEALASGEGPRDGRAIAARMRNTTYHSVMGYWVHMDEQGDAEGNYTLLSIDPSRPPGLYPLAVLHKSTPEVRFLREMEWPGGQVPLSEPPCGFRGEKCVSHIGAWALGASGGTLALLVLAALALYRGWRYEQELDSLLWKIDFRELHLPDEEQRANKMNSNAGGNVSSSTTAVGGEKNGGSTGGVRSSQVSLSSNPDLDFRYSAIFTEVALYRGRLLAVKRVRRHHIDINREIKKELKIMRDLQHDNVNGFVGACIEPPNVCALSEYCTRGSLKDILENEDIKLDNMFIASLVGDIIRGMIFIHESPLQYHGALRPSNCLVDARWVVKLADFGLKEFRKGELPPSESNALRSHVEGLAYLSPELLRSVGWGKETTNMTVELHDGSPQSDVYAFALVLYELHTRRGPFGGDALPVPSLLHRVASPDPVPYRPPLDALTGSFDCVRECCSECWAEEPTARPDFKAIRTRLRPLRKGMKPNIFDNMIAMMEKYANNLEALVDERTDQLQEEKKKTEALLEEMLPAPVAEQLKRGRRVMPESYDSVTIYFSDIVGFTAMSAESTPLQVVDFLNDLYTCFDSILENFDVYKVETIGDAYMVVSGLPIRNGILHAGEIASMALALLSATRAFRLRHRPDHRLMLRVGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRFESTGAPLKIHCSQACKTLLDQLGGYVLEERGIVSMKGKRDQVTYWLRGEEPTAAAARARRRLAARDNVQPPGSTDKRGQRSSLKTKNWKNQVGGLHRCCSLESPKKLRFASGNHLESHTDGVLHHRSDEYLMEVVGEGRLVPAQRCDLLEAPSLRQEYTSISCPIIEHTECIPAAPAAAADSPLLTKEAPPPACDAKQCDIKQCDIKLVINGCSYNERDGAGIPLLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6H4</accession>
    <name>A0A835G6H4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000503">
        <property type="protein sequence ID" value="KAF9407137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6H4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="204" mass="23088" checksum="E4199746C9BB85AE" modified="2021-09-29" version="1">MPEVVFYYFPVKALGESIRLLLAYGGQEFDDRRIPQSEWPAFKPKTPFGQMPVLVIDGKEYAQSLAISRYLGNKYGIAGASPEDALEIDQNVDLINDLRAKAAVVQYEPDEAVKEAKYADFVKNVFPDLLERLNAIFVKNNGHVALGKLTWGDFVFAGMFDYLKMMLRMPDLEKKYPVFQKIIDNVYSIPKVKAYADAAPPCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G737</accession>
    <name>A0A835G737_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000454">
        <property type="protein sequence ID" value="KAF9407609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G737"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1067" mass="114286" checksum="79014CD0491BD491" modified="2021-09-29" version="1" fragment="single">DDQTRLSTRSLMSRIMANRIFLLCLLVSCLTVNYIECRRGGGRSGGRSRGGSSHSSGHSWGSSHSSGHSWGSSHSSGSHWGSSSSSSHSYPSSSGLSGSGSHGYPSSSSGLSGYGSGSHSYPSSSSGLSGYGSNSHTYPSSSSGLSGYGSGSKYSSSSSGSTWHFGSSSYRPTSNHHYYHNNAPHSVPTYYSTPQYVYIQDYRSSNSRYGDLLTGLSLYNLGRSHSHYHNHYYYDDYYRHRYDSPSYGSTYTPQSKPQDEANCVLKVKENGREDALKIPCEIVSTFTQDSKKVTPPQQTQVNKTECTTTITKNTVPVTTTSTEKPSTTTTEKSSDILINYDKINFSDLSLDEMLSLANGKITIGPDGSMLIAVQSTPSPTIPSIYGMPTDAVRSPVPLYRARRSVTVPVTTETLSSVNGTVSYITKTVTSNATMVNVTVCITNSSFVDPLSVKGSPVDPNNMECAVEIQTKDAFLRTVVDCKTLVTYAKMPEPQPETGILPPREKLKSWLNSPPWWMSLFIAVGSSGRSGGGFSSSRSSGRSWGSSSSSGSHWGRSSTSSHSYPKSSSGLSGSSSHGYPSSSSGLSGYGSGSHSYPSSSSGLSGYGSNSHTYPSSSSGLSGYGSGSKYPSSSSGSSWNFGSSSYPSSSSGLSGSGSHGYPSSSSGLSGYGSGSHSYPSSSSGLSGYGSNSHTYPSSSSGLFGYGSGSKYPSSSSGSSWHFGSSSYPTSSSGISGSGSNYRPTSNHHYYHNNAPHSVPTYYSTPQYVYIQDYRSSNSRYGDLLTGLSLYNLGRSHSHYHNHYYYDDYYRHRYDSPSYGSTYTPQSKPQDEANCVLKVKENGREDALKIPCEIVSTFTQDSKKVTPPQQTQVNKTECKTTITNNTVPKPSTMSTNESNTKLVSMDTINFSALSLNELFTVAKGKMTMAPNGSMIVELPNSPPPSVNKTLPLNGTSSVTTQTSVNGTVSYITKTVTTNATTVNVTVCTTNSSFVDPLSVKGSPVDPNNMECAVEIQTRDAFLRTAIDCKTLMTYAKMPEPKRDTGMLPPREKLKSWLNNPPWWMSLFIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G762</accession>
    <name>A0A835G762_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000365">
        <property type="protein sequence ID" value="KAF9408724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G762"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="11">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="399" mass="42860" checksum="BE4EAE414136F167" modified="2021-09-29" version="1">MFTGKMGLPAGGGLSLFCPGGELGQPPPAHMGIPPPYQLDSKLAAGLARTPMYPFPGGTYPYPMLSPEMSQVAASWHTPTMYPISSAASGFRSPYPTSLPISSSSLSSELYRFSPTLGGGLGLGLGPALVPPPPSKSDLDSHHSRYARSLEKGSSSSSSDKPSDSSANSNNKEQNKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRRDKSDSSICSCILGGAPGTTTVTAPKRKSGKRTAVPQSWEWHALGREEQAKYYELARRERQLHMQLYPDWSSRANTQRGKKRKRKQETTDGGNNLKKCRARYGLDQQSQWCKPCSPESSSVMVSGGLGLLRPEPATSLPASSLVSPQEPTYAEEEVRSLHGSASGRVGDGTHADGDPAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7L9</accession>
    <name>A0A835G7L9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000309">
        <property type="protein sequence ID" value="KAF9409566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7L9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8332" checksum="838A4450162988B4" modified="2021-09-29" version="1">MRKTAMQRNPAFPSAMSSGYKSFYPSPCFGPPRNQCSAGSYAQPTHPFQPSNCFMTASAIRKMSNTTPPSGFGRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7V4</accession>
    <name>A0A835G7V4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7V4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="53583" checksum="4233F6F2292DC155" modified="2021-09-29" version="1" fragment="single">GISPSLNLTSSSNELAVFEKFVDEELIKTIIRYTNLYHCYFILNTDLRNHSRLLTWKDVTVPEMYIFLPITMLMTRNSRLTIEEHWSTNPLLNSPIYTTLMSRNQQKSSDSVGDNSLSDESFTSADNADDSTLVLDESENSDSSVASTSSVVKRLPARERNPPKRYGFTYISTASTSVNDSELSLEEALNGPEKEHWLRAVQAELQCFEDNKAWELADAPLDGTIVKLLLNVNIADMTLVVRHVVIWANRHAASAALPTSQTRSSIAALPGAVYCAQVSEVRDLGVIIDNKLTSSSHLNTAAKKEAQMLGFIKRNTKEFRLIRTNFFLYNSLVQSHLEFASEVWSPIYAVQSQRIESVQRAFTSHLAYISSGISHRVPFYQRLNYFRMNTLHNHSKIHDILILHKLLNGTADCSELSPCLARKLKSLGFDCMGILRTDRKFVPQALNSLTKRNMRQGQITGPPQGTRCHGMEKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Q2</accession>
    <name>A0A835G8Q2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000359">
        <property type="protein sequence ID" value="KAF9408815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Q2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="8793" checksum="67D7EA7738456CB7" modified="2021-09-29" version="1">MKNSRDIMRLVVPGCVNDARSIPALRVFVLASAMALYLTMGASVFQAIEGPLEQSIAEKLDQLKAQFLQDHPCVTGEFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G975</accession>
    <name>A0A835G975_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_010381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000257">
        <property type="protein sequence ID" value="KAF9410582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="930"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="976"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1557"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1615"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1728"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2102"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2189"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="976"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1557"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1590"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1622"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2116"/>
            <end position="2135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9410582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2211" mass="249026" checksum="FE122F67961683D3" modified="2021-09-29" version="1">MWPRVRVTRRQKQRSCACALSHNLWRYGPRRLRDLAARLLISSRISVSICSRKSEKVEDNENIPAGMGSMIGPLFNKERLSADDERPRPDESLIKKKVMTLVFFRESLLSALDRFLRPYYKHLTLAFTRSGNVLEDEESDDQVFAEYDDEKGVVFFPPVYAQRYAAVSDLLMDERWCGKLEKVVDFGHHDMSFIKYLKEVPGIRYILGVDIETIPLRCSSDLLSGDEYSPKRESPLQVTLFQGNAADPDYRLIGCDAVIAIEMIEHMLPHDLERLVHTVFGFIKPWVVIFTTPNADFNVLFKALEKNGLRRMDHFFEWTREQFNDWCSNIVVRYPNYTVTCQGIGPGPPGTLHLGCCSQLCLFISKNYHKQADLHINSLALVENAPTPNNFSDILVWESSVDTKQEIEHGATLAKPDTVESLTEIFYPEQQPHLRVVISSTLCNSMPYSDPTFTMKSYTYRDQTLQCNLDTEIGKSFLMFDNEDYYHVLVPRRRVIHKVYEIEDVFSRLNCTTLQVKKFSKTTQNLMAKNKIDSLVHTREVVNEIRHLTKTLNLNKFSRPEDGHHIWSNINWGENAPYWNQYYKIVKEYIYPFETKSDEVRILDLISEEINRLIDLQYDEEFSVDMNRLEIPLSHLMTVVQHITDDVDRVRDLLEWNGYEVVNDVVIHSRLVVDNTSVATQDDEWQDNDTLSDWDTDVRSTSLSDRSTIVPDLTGRCLRRALDQKVRNLRTMLIADEDITTELDRVVCRLMKLALQSSRARQTPPPSRWMQCKLLDLLTLTEKAIGRRKKQFIENYPILAIEGVKPPDLELDQDSRIKEIVEKYRHFIQPIEKMTNTDDTNYQNTDLDVEDEFLSTTSNEFLKDDEYIKGISPSLPVFSTENFVIAESAPTDVNPLERTKAWLDDDIEATTFPKHEVNYENISSVSSKFKIKRDDKHKKKNGNTKPTKKLPKKKPSYNTLIKKQYSSPEYDTYAVKSKRKNSRKFNRTLSSGMKDCQPSGGQPRIPTNNIDTSHNVVIAKMPDCDISATEESYLVDIVMQDFEETVALRRTVGTDAEKKLSEAECDIGSLNNDFDETICPKHEVSSENVQSQTIFLNDINEPSTSKGIRHNISTDVQCGPDTFATHPMLSASTSFVKIPPVFTAGVKIQEVGDDTNMKGIDIGTSTQVTNTTTITPRLRSVGIKIKDSDVNLNDKTESCTMTVQDSILQTSGMFSYSPKRSSGRNSIISSPETRLLKPISSYLKTEDSGSEFCEPSIASSSKTHTFFVNASINASQVLVKSPPGSKDVIIEASSSKNMRPRLSCGGVHVHSFRDKETSEDVVFQGQWQRHKPKACTRKRSCNFTSFRKANEAAVKKNRETLKEKGLGSKEKMFRRRQDKKQIEADIKKPIQVRNTKPQKLKLDEKSQTKKPVTSANKLSITANNIQRPVKTVTKVASKIGMSVISKTTKSTFTVKKPSILSNLAGKEDNDKPKKLKKSYIPLYLRLRKAALLSDSDKENINQNVDSVCGQDTLDKENRKIVQNVPIQDVKNDLLKFSDEVRENISYLVFRNELQDNVESPEDLSSGSTVDHSKSTPRPLEALKHSQSAQSLNSSTCSSPNSVATVRAVVTRSKILSHRRHSTSSYKSNLTTNSESDGTPTKIKKVIKRCKTVKKAETKDVNNKENVPESTQNFATKDKDKLSKLAFNSRHKSVYIAQIKTEGSPPPNTLSRHKTQIANKSNIIIAARKDSDEKRRASGPTVSKKKSIKSDTSSAYEDFITCQSDSCESSDSTNMVLVLEPQLNYDNILDLQNISHIRNTECNVDPNSHLVPEWVKNSSLHSRASNIFDSVRRILEDALDLAIRPGDHSMRHLGSKTVILKEQNHEVRDNRDDPSDVKAVSEPDTTQFLVRVIETALDKTFDTVLGDELNTVGINDTRLTAVDLDMLSFNSITSVSKILTDNELNVPRESEQAHSTVTAQNTTSVQDIFERKEPHLIQNTPGALAVQAFSGFSLDVEPVVGDQPDPVALIDSETGSPALQFTRLATSEELFISGRSSDSYESCLIDDDTVVPTWLFQLISQQQSVEDDREPVLLGPVAAPTNEPMYDANGNVIEPSLIGVSAGAGDGRGIHSDHSQDSSGRGTSLSSSDTSSGPQSAVSTILIDPAFTTPLDLLRDPMSSSAVLQSEPHSSDRTYRINNDLRIDRTGILSGASDVDADVSSIDTDVPDLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9D9</accession>
    <name>A0A835G9D9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000251">
        <property type="protein sequence ID" value="KAF9410705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9D9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="27387" checksum="150BCC71D047B960" modified="2021-09-29" version="1">MGCSIHYITPEMHHANGQVERYVRTLLNMLRVETYNKKSKWSEELWRLQLVLNVTKQKTTQASPLNLLIGIEGTTPVIKTLVRDVALDISSSDRRSLRELDRQRAAERLKDNQIRQDEDVNKTRRAPHVFQKDDLAFVIKYTQSKGKLDPGMRGPYRVTRVLENGRYELKLVAGAYGKVTYAAAQFMVPWKGEWTPDECAAFFAHPSDVTTTEVQSTPASDDEEVGAKIPAEDARVSGEAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9E1</accession>
    <name>A0A835G9E1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63535" checksum="910D8E908BFE9AE7" modified="2021-09-29" version="1">MGYFEAPGVLSPRHLAGDWSRFVDVNALLIFDYLPSCPEEWLQIEKDFALKFPRAVGSIDGKHIVLECSINSGSEYTLTVKAELSFMVKMQTNDLNLPQPHPLPENIMKPYSGNKLHLQHNTLGIPKTKVSGPRVVVENTYGILVTKFRIIKIHLQPEKAALITLTCILLHNFLRRNTTLSHIYTPSGTIDTNDNNNLLIEPGSWRYSTLSSRSAWNIYSILLYLILISLYNSLNISSFKFVFHSTGSAWKYSKNFNSSSFVQVTLILTPGGTQYTIVQVGGSRATEKLVSVESIHVLGCSHVLALLCLAPKNRQKVEKSRRTTRELEKNTRIASTFTFLASFSRSCEILLRMWNALKEAFATELCEIAGFETKLLCGDGQYYATTTDQQLDKSNKHQTWLLSFALNYSIKACTAFLFSLQTFDFFGLHYDALLPSPPFHKIYASLLVYGLSLHTIRVLGSSVKGKFWNVKSKVVVCEVDDIFNRLPLGTVLSGGNIGVVLPCSPVVFKVERFSVDGCSLVFVKSLLAPTSVHLNEDGGPMAFPLMYLPVLERYSFPSYSPQYDNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9G2</accession>
    <name>A0A835G9G2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IQ domain-containing protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_011254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000323">
        <property type="protein sequence ID" value="KAF9409360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9G2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9409360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="288" mass="33851" checksum="78125E603D1A7F73" modified="2021-09-29" version="1">MDSLFTEGSTKLRLADWQPANKIEKLQEIKLEKDRSLINDVIRKTLIEVAETGRWQSITYAVELLKQSECDVESLKVTNQRLKTTRKALAAELNAKRNQWALELRNADQKVAVLRDKMSDDLHNANTRLCYAEKWLFARFESLELKLDVPRAPPRAPTTSNGSMKSCSKLMNCRSKTIKNEHEKTLEYWRHRYDTDIAEISSRSQKKLEQLLIATSKRTELQKLYDLHEGEMRGWLTFKRERAARLEREERLRKSAMRIQAWWRGVMVRRALGQFKYLKNIKGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9K4</accession>
    <name>A0A835G9K4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000270">
        <property type="protein sequence ID" value="KAF9410281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9K4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="392" mass="44318" checksum="B55C70D646E9CF8C" modified="2021-09-29" version="1">MRESNGVSCEKPLGRRVAVPVIHVRGTHYEVGYDVGRTFSSIIKDFIATYENLRDFENVYATDTGRKAYDTTLANMKKKYPYYIKEMQGVADGAKVNFTQLFLLQMDDLIGNVNDNHIPRNDTGGCSSIAFKNSQTTLLGHTEDAFHETLNHFYIMSAHIIPSPEDAKAGAVEERFSSLCYAGHMPGYTMGFNENGLVFSINTLSPLILKYGNTPRTFITRAMLAAKNFEEAEHILLDQGLGIGNGFSVNMIWTNNWGDRQIYNIEVSPDLKADHSHLNVQKYDKEPLVHTNKYQRTNVTEVTGRIIDSSVARLRVIHSYPKPHTRKELAEILSDTSDKEFRLFQDHPDDIIMTIAAGIFDLDKRTWSIYINKPKCSEPVAVLPITFSSLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA36</accession>
    <name>A0A835GA36_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000298">
        <property type="protein sequence ID" value="KAF9409792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA36"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="10017" checksum="58CAB1E2106AABFC" modified="2021-09-29" version="1">MVEIFHEEMQLQYLFMRNQNKMTYQENLQDLDFWKYLVNIQGHFWGGPGWYRPRFGPRFGPGFGPYYGPVIAPLPPPPPPFFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB30</accession>
    <name>A0A835GB30_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_008451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB30"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF98">
        <property type="entry name" value="RE43130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="295"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9413285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="528" mass="61093" checksum="06022608A68E1880" modified="2021-09-29" version="1">MDRSLLYETIENCVMHVPWKITFLMYSGLTIKCGFKFQARIGIIHNEINTNTTIDIKFQARLFHQILLNAVTCIYNASMQTLQAVNVLNKLCKLAKPFRRPAVHVVTLYRFDKYIASCARAPVKVSGDLHAILFTVLGFTRGQAHSKFRSHYLLFSKTWPVTPDWYQVKKGDPKTCPRGNYLFIFFKKNIVLNVFLDKSPCSFFGNKIRSVVVIVVLTSRWSGAMAAMSGAPLLLANATLTSKLQDDDHRYAEPMKKNRDYEWQVVWRNVFAFVYLHAAALYGFYLMFTGKVRIWTILFGLLFAIMAGMGVTAGAHRLWAHRSYKARWPLRLFLALMQTMAFQNHIYEWVRDHRVHHKFTETDADPHNARRGFFFSHIGWLMVRKHKDVFEKGATVDMSDLEKDPIVMFQKKTYMVLMPLLCFVIPAWIPCYFWGENPWYSWYVASITRYTVALHFTWLVNSAAHIWGNRPYDKNIGATDNKAVAICAFGEGWHNYHHVFPGTTKQLNSEITAQTYQLLSLTSPLNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB40</accession>
    <name>A0A835GB40_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB40"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="17328" checksum="9264A2871530A649" modified="2021-09-29" version="1" fragment="single">LPAPPHIELVMAMPYLRTAFKRPTVRVRPATSSEMYTRNARSAVGALDGRGLVAVIKRQVPLAGQLDHQLAWGQGWGWVTLPNGVWSGRLTWSQEGEDFALHAMPIMHHTNVSQACSMLDGVTAYEASVYEQALAEYDDTGTSDDWDFGVDCGDFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB54</accession>
    <name>A0A835GB54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_009810</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tonsoku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000227">
        <property type="protein sequence ID" value="KAF9411363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="717"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="850"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9411363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1465" mass="165736" checksum="D546BA89868EE83B" modified="2021-09-29" version="1">MEEEKLIRRKKKALNSSNRRALAEAYHDLASFYYKHNRYSDALDEYKSEASIYKDLGLRLEWGTSNRMIGEMYMLLAEFDKALKYEERHLAVAKELKNLVEEQRAMATLGRIYLLQGQSTTDESESKVSLRAAEKAFMKSLVLCENLNGKINKHELMDMRARLLLNIGVVQEHLGNLDKALDCINKAISICSSQDLYEVLHNCYTTEALLHCNKKKDYAKALSCLNKALEVASRLEDKVLKTCETLASKADILCKMSDYQSAKQVLLKAWKMKTPDEEEHEVIESNLRVVAAMCYTEDLLVSTDPSDHSTFKKHYEKLGDGACHLKNYAGAIEYYLKMLDHAELAGECGKTLIPIYVSLYQTYKDMGSYNEALDYYEKEYELIKDVPKEAFTTMYNIAETLFLAKKPYGQIEKACLEARRAAQEWNKRKYEIRVLKSLLKYQEEYGETDKMEQIKDELRALGYENLDNLENSEDEQSSAGGGDEDIHIGDDICLDDLTDLSDTNEEEVTETKRETRKRGKGFTIKKNMKGETQLHVAAISGNKLLVERLIAQGHPVNIRDNAGWLPLHEACIHGHTEVVNILINNGANVNDRGGSNCDGITPLYDAASNGHLEVVQLLLEKGAISTLKTDFGETPLHVLQKWRTGTILTKDEETMYNNICNKIQNSIDKTNSAELFNRSKSRTPVKPVKDVTPPSTSKMKSRINELDTPVFKRRNIIDDDSDDDLDLSQNVRNEAAFPSDDSNSSDDTKVKDKKKSTGVKEYRSAIEALRNRSINDALEVETKKSKVKPALLDPEEVDDDWLDDDLGINKNNKKRKLSDPLTTVAKKPSYESIKDKIEDLNKITQPLVDNNRSSAKKKSRISDVIDVSENSSDSDSFRNENVRPRVTASQAMRNIAKELNETKSRDSRDNMKRRWKRQSTLLKAGFQRQREDDASNSGSDTEYSRRDINKRLTPTGTFTRKTSGENFGFNSSTHNDGFNIMQGMNPNIVQPMNVIQPINIVQSTKNGRPVQTQILPPAAVKVQVEDKVLLISLKLDTINKLTISWLVEEVKSRYYKLTGVRPVFSLMTSDGAILSEEDPLSLVLSSPELKTCITNWKASPAEERYLECCDALSIPPSEEIQQAVGRSHTTRRIALGARTLSSSQIRPLFRALTHQTHITAIMISDNNIGDAGVKYLTECLCTMKQLTHLDISRNNITSEGTKHLLTMFERTNRPACTTLEELDISSNPITDNGFRNIAKITQYVRLKTLKLNYCNITENAINDSIKSNMNFDCLESIDLSNNDVKQGVVSCIVTSLNPNVLVDLELDNVGVEANIVGCIASFMDSAKDLKIRRFALSNCKLVDGLFMRIFRSINRAKHLQTITLKNNNLTFITLKKLLQRQPPVPQINLQGCQDIFKYSPDSDFQVWLPAIDFGRCIPEINVTPVSKTDEERESFKSFSKTWLNCFKGRGMIEHCEGGVIKFTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB56</accession>
    <name>A0A835GB56_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB56"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="331"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="479" mass="52972" checksum="B758B624321746BD" modified="2021-09-29" version="1">MVIEKICCLGAGYVGGPTCSVIALKCPNIQVTVCDKSVERINQWNSEKLPIYEPGLDDVVKQCRGKNLFFSTDIAKGIQEADLIFISVNTPTKTFGNGKGRAADLKYVESAARMIADLATSNKIVVEKSTVPVKAAEIIMKILRANTKPGVEYQILSNPEFLAEGTAIVDLVEAERVLIGGEDTPEGQRAIQELCWVYEHWIPAKNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGRDSRIGPKFLEASIGFGGSCFQKDILNLIYLCECLNLPEVAAYWQQVLNLNDYQKTRFTRKVIESLFNTVSDKNIAILGFSFKKNTGDTRESPAIHVSKTLLDEGAKLHIYDPKVEQEQIFYELTSPYLTSEPEVVKKNVEIHDTAYSAVTGAHAIVLCTEWDEFKALDFKKIYEVMMKPAYIFDGRKILNHEALQNIGFHVQTIGKRLSRVGSIRAQGSQTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB89</accession>
    <name>A0A835GB89_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB89"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="46244" checksum="D4137DF43BFB3793" modified="2021-09-29" version="1">MIRSLKNKKNKNPCTTIHKYRLDKDIQKILYPFNLMFKLQFSSKYCIKDGYITANGVKSQILAFLNVCFVLVRTINAFGRNLGYLQNSIQIIKIKLNYHHRTIPYPDLMYCALTLIWMVKYISIIILQSVYCEKFYITVEKAEMECIQRMMNINCSNKDVQRIFYPFNCLLLLLCTPKYAIKDSYIVPNGMKQTILSFLIFGFMAFLWVIKDIVLIVIQSLQCEKFYIANERAKISCILPISDMNCSKGQIRLYKQLIQTNRGFSKMSAYGLFYVDARLTISVVGLFTGYHLYTYLIPSVGLAVFLWITKDILLLVAQNIECEKFYIANEQAKLACMQLMKNKNCSNPEKLLHKQVLRTSRAFSKISACGFFYIDAQLPMNVIGLLTGYVCVLIQFAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBS0</accession>
    <name>A0A835GBS0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_010141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000240">
        <property type="protein sequence ID" value="KAF9410943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBS0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="112"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9410943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="367" mass="40271" checksum="0BD0118EDEDA499C" modified="2021-09-29" version="1">MYHHKNAQLQLVAEVIASPFYECQPLFNAFEQRPLPPHVVSYLRRSQCGFEGYVPRVCCGPLPLEQEATSQRPTPRPTQPTQGTQGSSEVYSEDSSPAPRNQCGIDTTGDRVYGGTITDLDEFPWMALLGYRTSKGTTSYQCGGVLINHRYVLTAAHCITGAIEQAVGTLTTVRLGEYDTQQDVDCIDSVCADRPQEIRVASAYPHPGYSDKNKNRRDDIGIVRLATRAAYTYYVQPICLVENRARLDAGSDVYVAGWGKTLNGRNSPIKLKLGLPIFNKEECDDKYKRLGAILSDTQICAGGVFAEDACRGDSGGPLMKRTPNGIWEAVGVVSFGYGCGRDGWPGVYTSVAKYIDWIQNTIASSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC52</accession>
    <name>A0A835GC52_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_010359</name>
        <name evidence="8" type="ORF">HW555_009896</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000231">
        <property type="protein sequence ID" value="KAF9411239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000100">
        <property type="protein sequence ID" value="KAH9644144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC52"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9644144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="35838" checksum="044A347F708BA8F7" modified="2021-09-29" version="1">MAPVEKNLNNEQPKYLKGDIKASALELIGNTPIVALDRVYKGPGRILAKCEFMNPGASIKCRSSLNMINRAIESGELKPGDPVIEITSGNQGCGLAVVCAVLGHPLTLAMSKGNSVQRALHMEALGAKVVRVDQVKGTYGSVAYADVEVVREVCSKLVEEQNAYFVNQFSNEANADAHYKSTGPEIWEQTGHHVDAFVAAVGTAGTFMGTTRYLKEQNPNMKAYVVEPAGAEAIAGCPISKPLHLLQGSGYGLIPDLFRYEVMDGSLSVTDEEASRYMKLIGEKEGLYVGYTSGANVAAAAKLLESGLVPEDAWVVTVLADTGLKYTPVPEELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDF0</accession>
    <name>A0A835GDF0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000295">
        <property type="entry name" value="Glutathione S-transferase unclassified 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF7">
        <property type="entry name" value="GST-CONTAINING FLYWCH ZINC-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="232" mass="27067" checksum="FB5AADC4AFCAD30B" modified="2021-09-29" version="1">MVLKLYYLEDGPPSLSCRQTLEALGVPFELVNVSFYNGEHMTEEFAKKNPQKELPVLEDDGFFLNESVAMMQYICDKFKPNNSLYPTDPKARAIINQRLMFTSSTYYAELLNYFIMPIYFKYERTPEGLKRVHRALDLFETYLEREGTSYAAANHLTIADFPLINATMAMEVTDFDFSKYKRITKWYNDFKKNQPKLWSITAEGMSLMRKCVENPPDLSHLNHPLHPARKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDF8</accession>
    <name>A0A835GDF8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_009225</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000197">
        <property type="protein sequence ID" value="KAF9412202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07865">
        <property type="entry name" value="STKc_CDK9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000227">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="68"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="420"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="742"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9412202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="770" mass="88165" checksum="CD9AC84577CB0C86" modified="2021-09-29" version="1">MRVNRDARVMSGVEIESGKIASKMQGVSAPREPTQPVMSTSSTILNMREKEKYIEDFDFPFCDESSKYEKVAKIGQGTFGEVFKARARNSNKKFVAMKKVLMDNEKEGFPITALREIKILQLLKHENVVNLIEICRTKATFHNKYRSTFYLVFDFCEHDLAGLLSNVNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKNGILKLADFGLARAFSLAKSGQVNKYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGPTEQQQLILISQLCGSCTPDVWPGVENLDLYNKMELPKGQKRKVKERLKPYVKDPYGCDLLDKLLQLDPAKSIHKACSNTSLPPADLAIFGTIIMSLELKRSPRNQFRTQGIKTGSSEVEICRYIEDYQFSYCDASSKYEKVAKIGQGTFGEVFKARGNTNNFVAMKKVLMENEKEGFPITALREIKILQCLNHDNVVNLIEICRTKPGIDNKYRSTFYLVFEFCEHDLAGLLSNPKVKFSLGEIKKVMQQLLNALYYIHCNKILHRDMKPSNILITKNGTLKLTDFGLSRAYSAPQPGKVNRYTNRVVTLWYRPPELLLGERNYGPPIDMWGVGCIMAEMWIPTPIMQGSTEQQQLTLISQLCGSITPDIWPGVENLPLYSKMELPKGQKRRVKERLKPYVKDPYACDLLDKMLQLDPLKRCGTEAALNHDFFWTDPMPCDLANMLAQHKHSMFEYYHRKRPNDGHMRQPQAKRLKPVQDTGYQDRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF93</accession>
    <name>A0A835GF93_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF1">
        <property type="entry name" value="MINIATURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="359" mass="38430" checksum="7A3B65A86CF818B2" modified="2021-09-29" version="1">MWGVGEFDMRVKSCAASDGSGHVIQLSDEYGCVLRPKMISRFLKAKAVDERATVITYAFFHAFKFPDALSVHIRCKVEICRHGCLDHCQLAGVTPQRHGALDRKDDRTHQDHNEIKSSAEDGGLSDLSEEARLPLEEAFGDEVSGDVVLAPAPLPQRASAPVIEPETDHMSAVEELVEALARPFTDRPSNIDRERFPHGPRNFGTDMSPEPSGDGVVPAKAPGPAVAGPRSLRKRRTVRDARSADVGVSGIYEVVSEADLAFGPSRTEPVTVFSGRIREEVVYGICMGAVSFGALFASAAGAAAGAALAAAVLLQKLRSRMAVQPPIPVSPAPASHSLAAWMALRLLGSQPHPHHSRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFZ8</accession>
    <name>A0A835GFZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005745</name>
        <name evidence="6" type="ORF">HW555_008548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="200"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38992" checksum="B210586D6FC20F4F" modified="2021-09-29" version="1">MSGHPSASHGEPSTVVFQKTKRGRQMLCRAGYNYVLKRTNKDGSDLWRCTNKDSSKCNATLKVKPNPFIILHETSHNHPPRGEADMEIDREMYLCTETLQKNINKPVTQIYGDAVQNLINKGIDLLNPLPQFDNIKKKLYKLRNESQGAKKINFHKACELEVPKRYEDLLFAEYKENQKRILIFAKKEMVKYLKKSTKYLIDGTFKICPKCFCQVYTIHADIGSNQEYANVVPVLYALLPDKTRATYEILFQMIKSQVKEWQPTEISMDFEVTAILAIKDLFPEVKILGCYFHFNRCLWRKAKQLGVVKSKLGVIHVKLCTQLAHLPQTFWMKGGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGB9</accession>
    <name>A0A835GGB9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGB9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="78" mass="9117" checksum="B45001FEBCAC7409" modified="2021-09-29" version="1">MEKWFSSFVFQIPEKHIDMSDQLITTSLPRLRHIKKTLQMSISNQSEKSTLRGSEFYWPTQGIFQNNRVTSNDASPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGK9</accession>
    <name>A0A835GGK9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_007166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000118">
        <property type="protein sequence ID" value="KAF9415076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGK9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF2">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="53"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9415076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="35906" checksum="9BABCA925A8D07A6" modified="2021-09-29" version="1">MSGRLVFQSLYCSFTRKVPLKHSFSSSNRLYVGIFRVSSHEFCTKTEAQFVEKKHCNIGTIGHVDHGKTTLTAAITKILAKDGLAQYVSYDEIDRAPEEKARGITINAAHVGYSTKLRHYAHTDCPGHADFIRNMISGASQMDAAVLVVAANDGPMPQTREHLLLAKQVGIQYIIVFINKADLVDSELLELVEIEMRELLSDFGYDGNTVPMICGSAMKALNGDESEYGAPSIRKLLSTMDEYVPPIVRDLSSPFLMPIDNAFTVPGRGTVVVGTIKRGIMKKNAEADLLGFGQNIKTTISDVQIFKNSVPENLFLSLLSTNALGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGN0</accession>
    <name>A0A835GGN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001250">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DDX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="169"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="356" mass="39494" checksum="2B413F651CEB7EC7" modified="2021-09-29" version="1">MLNRKLKKMLEFKRMLPTETSAGSGLYAVLDFLEMLCDRSENGRVLAQGDQNGQLKYLLLNPAEHFSEVVRQCRSVIVAGGTMEPISEFQALLTSNKNDTDSLNIVRCEHVVPPQNVLGVCLSKGPTNVNLNFSYENRMSNELLSEVGRILRNICSIVPGGVVCFLPSYSYEQTVYEHLKTNKVIEAITKKKAIFREPKSASDVDQVLNKFASAVKNKDGDHNGALLLSVVGGKLSEGLNFSDDLGRCVMVVGMPYPNVKSPELQEKMNYLNKTAGGSAGNIYYENLCMKAVNQCIGRAVRHANDYSCVLLVDERYSRPQTMSALPSFVQKSLISNCNFGTTISNIARFFARHKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGP2</accession>
    <name>A0A835GGP2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2 7">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2 7"/>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGP2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000004">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="8">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="166" mass="18960" checksum="E1EFF13CF055767D" modified="2021-09-29" version="1">MRLLLRPIVIVRKALQANRSVQLKHPFTTALVWRAMEDKESLKKRLTPLQYHVTQEAGTERPFTGCYNKFYEEGMYCCVVCRQDLFTSKTKFDSGCGWPAFNDVLSKEKVTLHQDTSAGLVRTEVRCSKCSAHLGHVFDDGPAPTRKRFCINSASLDFIPAEERKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGP8</accession>
    <name>A0A835GGP8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shootin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF5">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61696" checksum="1A5B86B9AAE26116" modified="2021-09-29" version="1">MIFYTIKAVLQVNARDILRCAVMTPPDAQQHTKEANIAISTYVEKWKNRYEEAERKHKAYLLKTEKAKREYDDLQRRYNILFEERQHLESELRERSRELSKLKNVSEKLFNEYQQLKNQRDVDAGVMHKVMQQAGEWYKENKQLKRRSTALIQALPPRAIEIDYTDAIDAASDTSSNEEVEFLKSTVAELSAQVAALQTELGTAKLHEFEAHEANVAIAQELEAEKEKSAAQEKGAAGASHPAGETQPSVQATHGGGHRIQNGSPRSEEAREATELTKAAGTYRLMRDCRDCCMKWTVSRTHLEDQALRHRDQLDELQRKHEDTDILLWEEKIRLAEEDAQKALERAEAAERKLRELQQKTAARPQARDKLMARISYFEQGGQKKMDEVKEEVAAVSAPTTSSSPPQPSEPAPIPPAAPPAAPPVPPPPPVPQAPPPPPPLAAAPPPPPPPPPPPPAPVAFESSGADDMAQMLANKSGTLRKSKQNGADCGGAIDAIVDQIKGGKFHLKSTDQKFTEKKVKEEQPEAVKEMLAILGTLRKRRTTARPGFVEPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGP9</accession>
    <name>A0A835GGP9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGP9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="193" mass="20854" checksum="BF2AF85F61855766" modified="2021-09-29" version="1">MHTRIDSVLYQHSTIALAALEQNCSESMSLGSLVCSTCAVATETTDALLWEGNCWVQVVVFWSIPYDGLPDGGIVFDLLLADSAGVALLSISELVTVAAVDQQAISIVMSSAVWSILGKFSQTIPEVVEGDGGVSWQDGDPPRPNPCRSRYPPSKKSTGNGLALERIRNNYNKLIDNKRPVKQLLIFQNGCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGT5</accession>
    <name>A0A835GGT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_007568</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="59"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9414561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="617" mass="68687" checksum="052FF76779863100" modified="2021-09-29" version="1">MKVYAGMLYLFTLDNCVDIRYDPTLLDKSFACGFLWRYANGMIRSKRWGRQDATVAELFTRRALKNPDAPCFFVVGDRDWTFGQMAANSNKVARVMQEHMGLKRGDVVCVFMPNCGEYVWTWLGMAKLGAVSALINSNLRHKPLLHCIQVAKAKAIVFSDQLADAISEVRDQLPEGLKLFQLYGECAPGVLDLAAEMEKHPPEYPIVTDKPRYKDTLLYIYTSGTTGMPKSAILPNSKYLLVVVATVHMLGLKKSDRMYNPLPLYHMAGGLVGTGAALVDGIPSVLRTKFSASNYWTDCIKYDCTVAQYIGEMCRYLLAQPARASDAQHRVRIMVGNGMRSAIWQQIVDRFKVPQINEIYGATEGNANIINVDNTVGAVGFLPKLVPTSLHPIALVKADEHGTLLRGDDGYCIRCKPHEPGMFIGLIAQGNASREYYGYVDKDDSNKKLVRDVFCKGDAAFVSGDILVADELGYLYFRDRTGDTYKWKGENVATAEVENAMSPSLQQKACVVYGVSIPQTEGRAGMACIADPARALPLSRLARDLDDSLPSYARPLFLRIINDIEITGTFKLKKLQYQKEGFDPEVIKDPLYFRLGADFVPITPQLYTDICTGKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHA5</accession>
    <name>A0A835GHA5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHA5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21010">
        <property type="entry name" value="AGAP001581-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21010:SF3">
        <property type="entry name" value="DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="230" mass="26732" checksum="1B13EA6127FE5B61" modified="2021-09-29" version="1">MTSTNLVGKFTQSVRRIVQDVKDEGTSSGQTKEEVIETNERLRGVRVRLDENYDTAKKALVTLMARYSESKSQRNVFTRYALLKAMIKDVIRLETQYWSLVEIPRQEKAETVPAFVLRACAIMEKTQKSGEGVKTSAKLAEEAADKRERIERLNDMTTIQIETENTQMTNDLYRLLKKYTGLRNLIRELKSDYVSSKVYPIFPRYTMLKDMIKDIMHDPDYMEVCHEVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHC3</accession>
    <name>A0A835GHC3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHC3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="363" mass="39885" checksum="422D0FBE90C0B373" modified="2021-09-29" version="1">MESVAAAENRRCYWCGPLAEQVHRSQRALPCSGGQTQVTVCDPGYQYCAVVATSPPYKESRYCVKLYQDECYALYCNSTKTWRMTCPCRGDLCNGPNTERELEAFTGLAKIVSKTHNARLRRALVTTGLFISLNPRRNRIDNATDEGVADIENDINSTNINGDLANENLDENVVNIVTEAKSEEQVVETTQVSAELKNSEAPSSPTEMMIESTKMNSLMNESLIQVDIPGESMETSNLKTEIILLNNGTDKDVAKTEEDIPEVQTSPEATTQTALETKAMVETTPEAVKTSPTEAKVNDLKPSEQLPTAEAFQFTDAPTTKTTETIMITSTTETTMPPKNNTATSFDTNVLTLAVGVVLNYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHK4</accession>
    <name>A0A835GHK4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Gooseberry</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_005966</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF3">
        <property type="entry name" value="PROTEIN GOOSEBERRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9416836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53080" checksum="4739192CB5CD0FBA" modified="2021-09-29" version="1">MCQVDEPNVAASEFALGQGRVNQLGGLFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVEARIEELKRQNPGIFSWEIREKLIKVVRDKRVGLQEGVSDPPSISSISRLLRGGARDPDGKKDYSIDGILGGRGSDSSDIDSEPGLTLKRKQRRSRTTFTGEQLDALERAFHRTQYPDVYTREELALQTGLTEARIQVWFSNRRARLRKHTGSNPSPGIGAYSSIPMPQMPCPYPAGEIPSLSQHHPQHPDAWHHQKYANYNQLMAQSQHLNQAFQNAAFPSTSGSTFSHLVPSANGPPHSQLLDSGIPRNDYARYPTTSEIYNKPINYLPKEAEVDDKVTSDEVIEPREDTFEKPTGDEYSKALPNNDYPKVPADYSKLSADPSVTSNWSPSHNSLNMSLAGLSSEYKYMNDPYSFPNVSDPLSQHNYPNPPNTANKYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIT9</accession>
    <name>A0A835GIT9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIT9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000009">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="598" mass="65284" checksum="4CE55CB8F712CDC7" modified="2021-09-29" version="1" fragment="single">RGAHHMKQLEADMGITHTRRKRRFKNDNTEKDAVVQNADVEMGDDSKPDSTAEVKDEPGESTHSIAHTNFNNKTGVPNTNFKEGILWNVANDGPPPEGFTIYTTDSGLTVLRRKRQRNLNKLGIGGFVVRQRQTTAKAQADEDKEGDGTQASGESPSNKRKPRRKPRSKLMEQFPSYMQEAFFGKELLEPTKAAVSSTVNIAYNLERVVYNGEGRPAGNPAESPAARASPEPSWARWELDNSDSEGEDVLAALHSYSDHDCSVLISLNTDEVEILNSLKPKDEKDDTSNTTNSDGTLKIKTELDDGQLKHTEDSTALKNAILGPQPAEAEQPPTVATESIPTVHSTKTETISETGGSSQASTISPKDDLSLLGVSLDAMVRDGLPDMDSNDVDEIFKGVLTDDSQESQESSVSYVNSMASTPYSQQRQQLQSPMEYTSPYPEFGGSSSNSAMSPLFSESGSGGATWPDPAQAPPPSYNQRSADKMRADESLGSAATISAVLYANTNHPEWKTEFPNWVDRCKQILKKWRALPSDQKAPYLQRARDNRSAIRMKKAQQTGLSRSRSRPRLPVVNTTVAVDSVACLNASTSVNNAAVGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIU2</accession>
    <name>A0A835GIU2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIU2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF6">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="316"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="50661" checksum="29C73D4DB4420886" modified="2021-09-29" version="1">MENDWTGLDKYYKDPSLKDIYETLLSKDLSDCVMHARSVLSKTNNWMKFMFNEKSTLISGYYLKHGSLMSERDPEQALLKYNTALLLAPFDSETMKLAYRARADISLCFLQCNSCINNINTCLALNCSQDLVNELMEMKSKAEQLVYIEKQASDILSSSFTDNFFNIKGNNVEVPCATPDVDVKVEAGRVKVVAARDVAVGTLLAKETAFMTATHSKNKFISCHYCLRISPDLKPCDGCCKALFCDENCKEKSMLEGHDVECKIIDIIVDDVKLPFKALLKIRRLCNSWDEFIAVSNILGTDGMNNEFTERIFGSNKFSVLKSRADKRFIHGKMFNSCMCIVNIIHYLELRTSFLPECAEEKEAVIRAVARIFLYLSLYCTPVRMLHAISLGEMQLHDYTNRGYFPLIGNLEHSCTPNTFVIGLRNSVALLALQPIKKGEQLTFSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJU5</accession>
    <name>A0A835GJU5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJU5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="498" mass="55489" checksum="6285CD95387B94DF" modified="2021-09-29" version="1">MFAKLYVELLLAQQHNNTIEPPLYPPVSPRCRSRLSPKFDTNHTSQSDDLKVHEINIDTTKRLLPHVLVDSPVAEIPLSLLVDSGSAICLLKHSSISKHPRLIKEPIKLKGIDPGDEPTTTEDPLALNDNDLLPLPEIEPAPESSEIPKENTKNNLPSTTGCSSTPDAPATTPLVQQPNANPEIVNDLPDLFDDNYPAFLKTIARKDNISFNTMKTMAYNMTKPLKHYNLIKKKLALLIKENILVTTSVLTQYNATLSKIIENEANSKEAIDKLSTNIRNITEMTNGLQIQASVNEVINALETSILTLSFQLENIINAILFSSQNILHPAIATPTQLHKELADNYRHLPSDLELPVPLDIKSIYIILSISNNKVIFILQVPMVKTQGYVLFHNIALPTPHNTSNPNSFSLILPDYKYLAMTKDKSFYCAFNSLEICKTVTPGNYICDIENVYSTEAKPICESELLTKPEPDLETTNRQTDCEDSTPNMSNIAPLRITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKE8</accession>
    <name>A0A835GKE8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKE8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="120"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="461"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="798" mass="89051" checksum="E7F13BE1BC03871F" modified="2021-09-29" version="1" fragment="single">LLSLDVSSLEDVYWLEDSTARHVLDPKDFGAWSAARQSLPTGKEALQTLKADLWSAVVKNSKHQDAWTWGGMLVVSVSVCGLVTLAAMTQPSLAPEAKHSLLQYVTGKYLHPPSCRVEWGWTEPQAVGETMCFTVHCFQRNGQPYPICDTDELTVAITHGSRKVSGVGFNFWVTAVIELGSGDPAQANTARVKFTVRQAGVYIVSVMIGLVPVAGSPFRKWFTAGRGFSIEISPLGAEVDESLSSAATFSYDSVNQRVSVSLCFERAGLYRARVLYRGQMLHNGEFDCIVLTASDTATVQRNISSKRHNICYEARLLSGKPRRVLCCISPKQLTLKDYLFKFIPKRITSFRLCPSTKLILKPTPLGSGPGGEFTLEDGVQPQLELVSAERDLIAATFTQLLIANCGGEDTFKNKQDFFYSEIRKAHSRYPHEKLAIRVVRSELLRSSLKATRHFTVQDWCKNFDITFQGEQGVDWGGVRREWFSLLCGQLFDPKFGLFVSFHDSPTGLVHPNPDRPPHLKLKHFELAGKLVGKCVYESALGGAYRQLVRARLTRSFLAQLIGLRVHYKYFEQDDPELYLSKIKYVLETDLDSGDSVPELYFADDVYDSSGRLVETHDLLPNGSTIRVRNCNKISYLDALAQWRLAARVRAETEAFLRGLGVLVPDNLLAIFDENELELLLCGTGELSVQDWRAHALVQGAGRDWERVLAWFWAALSSFTTEERARLLQFTTGCSQLPPGGFQELNPRFQITAAPNFGALPTAHTCFNQLCLPDYDSYEQLVHALLWAINEGGEGFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL55</accession>
    <name>A0A835GL55_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL55"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="290" mass="32471" checksum="349B24E496EFF1A7" modified="2021-09-29" version="1">MYDTKDLNAESSEIISEAVDPPPGLAKQYQEPEAAATDDHTDHSIELVGGSQTFFPTFANLFEPRQQNNFRLGGFGNQEGAYSQRPNSYRSLLNYPLFGGYNRNLENFGKHSTPTAAPLVEASSSLLGSGNFGIIRGGTFFAQNDEDEFGDGYNSYYNNGHGRPSYELGYIANPRPNYNQDQFANFRDFADINTPSNSAYSHYVVVYANKNSTMDEISEETRRVLSKPKNIIETLERIDKTTSAPKLSKAKSKLEATKQKMLNKKEQWKKTNSKFVSQKHDAEEPLLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLB4</accession>
    <name>A0A835GLB4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLB4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032965443" description="Takeout" evidence="4">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25838" checksum="9AD6859C13B69737" modified="2021-09-29" version="1">MKGLVVIFVICVLGVAQGGFITPCKQEDTACLKASAQAALPLLAAGVPEMGISVMDPMHVDQVKTVEAGLAMDFRNTYVKGLKNCKVLKLTRHPHRTDLDLKCSVTMDGDYTLGGKLLIMPIEGSGKYTIKIRGIVVKIQLNVEEKTRDGDKYWVVDSWKHVANVEKGVHFKFRNLFNGNRQLSDAIHEFANQNWQDIFQEVAPPIVKAIVAKIVAETTKLFDHVPIKDLVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLQ0</accession>
    <name>A0A835GLQ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_011057</name>
        <name evidence="4" type="ORF">HF086_016637</name>
        <name evidence="2" type="ORF">HW555_005232</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000834">
        <property type="protein sequence ID" value="KAH9630175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000605">
        <property type="protein sequence ID" value="KAH9634549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLQ0"/>
    <dbReference type="OrthoDB" id="6415465at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033011372" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9630175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9634549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="155" mass="17463" checksum="AF075F96CEDDB19D" modified="2021-09-29" version="1">MRSLILLFLPLLAPESECDLLRDSVHVTSAAARPNNELWCYKCLAEVPDDRCADLRHNNSALIHKCHNDRRMCMVKRFSFTTSTENSTTLPKMWALERNCTKHCEPGCIVIGERTKLYACTSCCTTSLCNYGSGAEEMELLDLLMVTVVAVFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM23</accession>
    <name>A0A835GM23_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="9">PPIase</shortName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000287">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="531" mass="61738" checksum="A21424F4D6C0C693" modified="2021-09-29" version="1">MIEEKEAKARATILEIVGDLPDADIAPPENVLFVCKLNPVTTDDDLEIIFSRFGKIVSCEVIRDKKTGDSLQYAFIEFDDKKSCEDAYFKMDNVLIDDRRIHVDFSQSVSKMKWLGKGRGVKYFNDDEAQEREKGNNVKNDKYAHSRNKANDHKNNDRHHSNNKRHDDREKEKEKEHRSDRHSRREREPNHRAEERSNRKRSRSRSKRDRSRDGRNNHTNDNNVSRNSDRSIKEYNRNDSSRYNNDRKRDGSVDNNISRSSNRTSKDNKHESNKKGNETSKNNDHGVSRNSERSTREYKHDSDRHENDRNKLKHNDKNSSRSSDKNVKEYKQDLQRNEYVKNRGNYDSEQKAKASPARQKESDKSIENKSRHEYNDRYTDRDVQSNKLKRKSEDDPETKSKKHKKDGQNIEARTPTPTDTKKKLKTSSKHTIKKVKTKKVVKKKRKQSTSSDSSTESSSSSSTESSSSSEEDRKKKSLKRRKKKYSTSSTSSSDSTSSSSSSTDSSSSSSSSSDDGKRKKRRKHSNKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM78</accession>
    <name>A0A835GM78_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_003359</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="151"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9420437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="418" mass="46493" checksum="7B0F10BACDD4BDDF" modified="2021-09-29" version="1">MLEQNISVMEFVTSSLGVYKWSCGCRTSIRWAGLSGAEWRKCWWPGLTAVCSVCGAGASSPPFVLLLTHCDRLLIIITMNWAVLLVCLVSWTSCQAATMVEPQEKEKGLIEWITNLLGNNPSTTTVTPIYQEPPTNCPVCQCGVARTKRRIVGGYETKEREYPWMAMLMYNGRFFCGGSLINDLYVLTAAHCTGYRKERITIRLLEHDTTNPNETKTIDRKVAAVIRHQRYNPGTYDNDIALMRLDERLDLSTAVKRIRRDEDGTTPATEETTATPDPADDVRVRPVCLPTPGLSYTRECAVVIGWGVTDEGGSVSNTLQEVKVPIVSNAECKDRSYGRRITDNMMCAGEPDGGRDACQGDSGGPLHVFNQTTEKYQEVGVVSWGEGCARPDKYGVYSRVNRYLTWIKSNTADACYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNE6</accession>
    <name>A0A835GNE6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="285"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="516"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="585" mass="65031" checksum="F9E696CE6546721B" modified="2021-09-29" version="1" fragment="single">MGNKQAQCHRPLPTGRLAALQAGRKRKGEDGVFLVRESNTSPGDYVLSVLHQGEVVHYQIRRHGEDAFFSIEEHTTVHGLDTLIQHYRGDSNGLVTRLSVVCKGQPPPHESRTQGTTNLLHRATEAGDFNVVSQLLACGYRNRDAKNQDGQTAVHIAARSGRDSILAKLIESGATVNVRDSFGYTPLHYTCQNNLPSTTELLITKGNANYQMRHAPTGKVPLHDAAQRGHIECIKVLLKLKAPAHARTLAHDTPADLAKHYGHTECYQLLKNHQPEVPKTSKKLWYHGTLNREEAVKTLEEYCKHHKVEGKASDGVFLVRYSERHTGAYVLTMLSENTPYNFIIRKEANWLFIDDGPYLESLERLIEHYSTVPDGLPTRLTTAVPPKPKPPLPEFSTMPRTKKLASSRAAMSNQSLSLVKHDILSDKQMSAQTSPPTSIQSNNNMFELLTRNLSFSSDFNNDSINNNEDPLDDNDTYKVPANNSAVVTLAENYNEISINSDGQLSTLQEFIPMSELTLGAVLGEGEFGSVLRATYSPADQPAQPVAVKTLHMQHTDTNKKEFLSEAKVMMSVRHRCIVRLIGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPD7</accession>
    <name>A0A835GPD7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPD7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF6">
        <property type="entry name" value="HEAD-SPECIFIC GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="4">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Haem NO binding associated" evidence="5">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="307" mass="34803" checksum="F3BDA4FC98F92DA0" modified="2021-09-29" version="1">MNECLHAAVTALTKNQAEHYDKYHCLRRLPDDVKTCRNYAYLQEIYDAVRATDSVSTKDFMAKLGEYLILTAFSHNCRLERAFKCLGTNLTEFLTTLDSVHDVLHDQDDALKDETVEYEANFVCTTSQEGKIELHLTTESEPVAYLLVGSLKSIARLLYDTQTDIRLTSYTNDPRRFKYEINAVPLHQKSKDSDCEQSEASNIATSTKVTDLKIGVASFCKAFPWHFVTDKRLELVQLGAGFMRLFGTYLASHGSSLGTYFRLLRPRGVPLDFREILKRVNTPFMFCLKVPGSSSPAEVSDHLVLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPP0</accession>
    <name>A0A835GPP0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="13094" checksum="D51840D2B486EB42" modified="2021-09-29" version="1">MCVDIYFYELQNGRYHRTFVEIHSKLCDFAETGTLFGDSMKRAIKNQPCPFQPGHVAFTNLSIPLQNIPKTFPYKQGRLYCNTTLIRNGVLSRLAETYINMEVKSGIVKKPTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQF6</accession>
    <name>A0A835GQF6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="197" mass="22735" checksum="88F839B4FD117248" modified="2021-09-29" version="1">MMDGLLRIVINKTPFLHRDFYCGHLERDRRLNLSMTADILINGNVETRESSARLKKSEGDVFLPLFPGTTEMDQLKRTFMDLGTPSDMIWPGYSTLPLVRDITFDEYPPGGLRKMIDPELLSKKKCEVKMKLFETILILRYAHHVIKTITIGYIPRLLNFPITFIGLLKILNLSIELMEGHSELTEQPTSKRGKWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQF8</accession>
    <name>A0A835GQF8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF24">
        <property type="entry name" value="NO EXTENDED MEMORY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="282" mass="31139" checksum="2C8F2BEA486AE1E8" modified="2021-09-29" version="1">MENQRSRSYESDDHERGACEWCEYALVITLATILLIGVSALTVFWVFYYREGYAWADDLPDKQFNLHPTLMVAGFITFSAVLLYRICRCFRRIYVKLLHAIFHALAFPCIVIGFLAVLDYHNKKGINNFYSLHSWIGFVAMGLFGIQYAVGFFSFLLLLICNKGTAGFRASLVPIHAAFGILTFVLGVCACLTGLTEKALFSIGVERYSGMVDEGIIINAIGVACIAILAVVMSEVYATLNNESIVVNAIGMSVVAVAILVLYTVRGTGGYRLRKVAAQHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQK1</accession>
    <name>A0A835GQK1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9423999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQK1"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="82"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="615" mass="68202" checksum="28E6722B45F217D3" modified="2021-09-29" version="1">MAPKTQSPPPRKPLQDYLPNPFSRKPPPKTPVGGFGERITNAINNNFRGLIGVLVPLAALSWQISKDNNKVKVKLMWMLMTWFYLVQPVSIPAVGFIPIFLLPMSGVMSTVDTCKCYMTEYVLLFVIASMILVVLNNSGIDRRLCLWLVCSGDACQFSGKRLVFKCSIAAYFLSIFSSRLIVSSTLTQIVTNAVMKLETGKKDENNPNFSTMRYIINNAIQTSSGIGSIAFFHSSFVTVLFRGAFAEFAPKSKEYPDIFNYLQYSAFAFPLSFIMFLINVSYHMMLINWSLSRGMSAVKMEELRSILLNTKKEIPRKVSLHERLSVISLILIIVAFFFRWNQWVDGWSEFRRDKDSPEIPRVKDTTVAAIFLIVLHIIPKSYRFVEYLDADKKSELPPLKAESAILWWKFVDSNVNYGYIFVFGATHALVKAARLTGLDKEIAENSGTFITEKSWNVGILIVLIAATILANITTAVAACSIWIPYVLCCSVDAAIPWPSKVYIAALGVGVACSFGFCLPFRYTPAYFCHHTGKVPIKKMIKYSIVPVIICLICLYIALLLWAPYLFDPNDNGVVVVDEPLAAGATKGPPAAAGGPEDAPPDAGAPPEDAGPPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQQ5</accession>
    <name>A0A835GQQ5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_004688</name>
        <name evidence="2" type="ORF">HW555_001332</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000758">
        <property type="protein sequence ID" value="KAH9631527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQQ5"/>
    <dbReference type="OrthoDB" id="7465547at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032694993" evidence="1">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9631527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="254" mass="25802" checksum="94AA58D919B6D05A" modified="2021-09-29" version="1">MRFIYTCLCFASVLKIVLPAPADGFVFPDDRRREKKLEPVITPPVLPVLEHLERDPSTLLPHERRAAGPGQVKPRFGFGGGFNVAPSGTGGLTASVSSSANGLGASQSASQSFSFGFNEGFSASHSASQASSFNGFGSGFSGSQASSQAASFSGSGISASGAASSASALGGGFGGGSQSQSASSAFGFNSLNGFPQQPYFGDGLLDVRHRGIPNFPFPNFVGRSKGAGAAAFRSGKAGPSSRNNNDFLAVLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQW4</accession>
    <name>A0A835GQW4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQW4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="102" mass="11629" checksum="C4735A7BE365C890" modified="2021-09-29" version="1">MNKTIIKVWFFTKPREREEIAYKCLRSTREREEMAINASVPSKKDPVLYYGRDTEPQKITKDHKIVTMMSNVVYVEGGCVPSDCDDDNCCPLIGLGADVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRZ7</accession>
    <name>A0A835GRZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035237">
        <property type="term" value="F:corazonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000319">
        <property type="entry name" value="Drm corazonin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF163">
        <property type="entry name" value="CORAZONIN RECEPTOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="101"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9422474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="418" mass="48195" checksum="7C5E1DAEC3545737" modified="2021-09-29" version="1">MDSAGNNTTLYDDDSLYPSELALHREFSSTETVLDSYTPWPTEKCLETFLFNGTQFDDVTNRVFIYNGTRVMCLDHAPVLTKSTLIRASVLSAMAILSFFGNLATIISIQKGKRGRGRARPSWTAIYSLIFQLSIADLLVTVFCIAGEAAWSFTVQWYAGNIACKLFKFLQMFALYLSTFILVLIGVDRWLAVKYPMRSMATATRSGRLVIIAWVLSLVLSVPQAVVFRVAQGPFIEEFHQCVTHGFYTERWQEQAYTTLSLIFMFILPLVILVSTYVSTVRTIAKSEKVFKPEVRRQEKYFTPDMNRRRLIDRAKMKSLRMSVVIVAAFLIWWTPYYVMMIIFTFLNPDKDQSEELLSGIFFFGMSNSLVNPVIYGAFHLWPKKNRSHRHSDRYDDIITSFGHWVPFHSYWRSPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS86</accession>
    <name>A0A835GS86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sorting nexin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000237</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07623">
        <property type="entry name" value="BAR_SNX1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="13">
        <location>
            <begin position="174"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46043" checksum="1ACF81CA16CA03A8" modified="2021-09-29" version="1">MSEEPDTPPFSTVDINNDNRDDEDLFASAVQEVSLDSEVNGAREGGEKAAISDAPPSINTSLGSPIMEEIATERANNIIITITEPQKIGEGMSTTKLKMTSTPSTESANGSSAAGSVQSQFVERRRAALERFLNRVAQHPVLCIDPDFREFLESDTELPKATSTSALSGAGVLRLFNKVGETVNKITYRMDESDPWFEERSARVEALEACLRRLYGACEALAGERRELGARTAEAARACAALSGADPHAPLSRALSHTADLHEKIEHLRLEQSNTDFYVLAEHVKDYLGLIGAIKDVFHERVKVFQNWQHAQMQLTKRRENKAKAELANRPEKIEQAANEIIEWEAKVERGQQEFDTISRVIKKELERWDEVRLHDLRHALLRYLDDHMKHQAQAIRYWDAFLPEARAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSL3</accession>
    <name>A0A835GSL3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="4">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Malonate-semialdehyde dehydrogenase [acylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_001472</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="15">
        <location>
            <begin position="36"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9422929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="522" mass="56130" checksum="EC244614C8575583" modified="2021-09-29" version="1">MASAMLKLLKTESRHVLRRSYSSAAPTTKLFIDGQFVESKTSNWIDLTNPATNEVIGRVPEATKDELNAALESAKKAYKSWSQSTIMTRQQLMFRFARLLRENQSKLAAKITEEQGKTLADAEGDVLRGIQSVENSCSITTLQLGDCIQNIAKDMDTHSYKVPLGVVGGVAAFNFPVMIPLWMFPPALATGNTCIIKPSEQDPGATVMMMELLNEAGAPPGVVNVIHGTHDPVNFICDHPDIKAVSFVGGDAAGKHIYTRASANGKRVQSNMGAKNHGVIMPDANKEHTLNQLAGAAFGAAGQRCMALSTAVFVGEAKEWIPDLVARAKALKVNAGHVPATDVGPVISPKAKERIHRLIESGVKEGAKLALDGRGIVVPGFEKGNFVGPTVITDVQTNMECYREEIFGPVIVCLFVDTLDQAIQMINANPYGNGTAIFTTNGATARKFANEIDVGQVGVNVPIPVPLSMFSFTGSRGSFLGTNHFCGKQGIDFFTELKTVVSFWRQSDVSHAKSAVAMPTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSZ3</accession>
    <name>A0A835GSZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_001054</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF385">
        <property type="entry name" value="GH01279P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032289187" description="TIR domain-containing protein" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9423499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1343" mass="152747" checksum="01C6CD91A1A4022A" modified="2021-09-29" version="1">MTRNFNGMVSLKVWMCLVFVAGARARSAPPAPTGCHWDYSDTKLSESNFLTCNIKTIGSVDFLFKNITTAQAYNINKLKLTCTDLLFFESSLHMNTGSFLGQLRKLEDLRIEYCKIRYVPATVLSPLRDLTSLTLRSYNTDWPAMTMEFHAESFRGLMELRTLDLGDNNIYMLPSEVFCPLFSLESLNLTNNRIQDISEIGFSDWGKGPIAPGKSCNTGLKMLDLSHNNILRLPDNGLSSLRSLEVLNIQNNLINEIGDRAFVGLNSLKILNLSGNKLVAVPPELFQSSRVIKEISLANNSLSVLAPGLLEGLDQLEKLDLSRNRLTNDWVNRDTFAGLIRLVILNLSYNSLARLDPKSFHDLNNLQVLNLDNNAIEIISNGAFAELKNLHQLSISDNKIKTLNEHIFSNLFVLSQLYLDNNLISTIHESCFENITYLQDLGLNGNSLNTIPDGIKKLRFLKSLDIGKNNISKVANTSFEGLEELYGLRLVDNQITSVLKDTFSTLPSLQVLNLASNKIDTIEQDAFLSNPTLKAIRLDGNKLTDIRGVFNKLNTLGWLNISDNKLIYFDYSYMPASLEWLDIHSNNIAKLENEKNAQQNIRMLDVSYNALEDVDERSIPDSIEVLFLNNNKIHTIHPGTFLQKRNLEKVVVTDNKLRTVELSAFTLPHIPKHRMLPKFFIGNNPFVCNCHMIWLQKINLWNHMRQYPRFMDLDTVTCEVVNNKYGGKANLMDVPETQFLCSYETHCSSSCFCCDFEACDCKMTCPDGCSCFHDSNWNSNVIDCSNVGYTEIPEKIPMDATELYLDGNDFRALNSHLFIGKKKLHKLYLNNSNIANIDNDTLNGLHSLNVLHLENNHLTELSVGVFSQTKHLRELYLNDNLLTSVANKTFENLSSLRVAHFQGNKILDLDKKLAHVSHLESVNIQGNLFTCSCENIMALQNWFKKYYEDPAEMLCVSENGLISNYTVFDAIDKCRDSSDMDNTIPTENQPYQYDEVSPIKLNFVPLLAVVLISVILILLFGALAFSFRQNVRLWAHSKYGVRLFKSASIQESELDRDRLYDGYAVYSLLDDDFVSKVVAPEMEHSGYTMCFHYRDLQHTPDNYLSEQITNAAESSKRILVFVSFNFLQNEWSKATFKAAMKHVITSIHPSIRRHRVVFILTTDVSALNLDLDFQNYLKTCNVLLWGEKKFWEKIRFVMPDISNLHWNKDTMNYNHGVCPNGRRHPSRYTASPTAPEHWYKYDAIPPQTPTTANVGIVIEDDTSMLTNTTLTSQIQDGENLHHSYISIDTQNYEQPYGGRPRPPNTLRKHPGHHSPSMLDEQGYLQPRSSVHDCLPQTHPAVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT71</accession>
    <name>A0A835GT71_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000692</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9423983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT71"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="37"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="511"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9423983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="596" mass="68186" checksum="2BDD1CABBBCA3C12" modified="2021-09-29" version="1">MVIKDWTKISPGLSKPVLSCIEKQGFKTMTPIQAAVIPLIMSCKDVVAEAVTGSGKTLAFVVPMLEMLIKKQKESQLRKDYVYAVIISPTRELASQIYKVIELFLQEPELSHITMALLLGGRPVEADIEAIQKGAQIAVCTPGRLGDLLAERKQLNLSGRLKEMDILVLDEADRLLDLGFSQTLTTILQYLPRQRRTGLFSATQTKELQDLVRAGLRNPVVVSVKEKSTISTPILLENYYVIVEPEDKFLFLLNFIRNRKIAKGLFFLPTCACVDYWADVLPVFLPDIKIFSIHGKMKMKRSKILEKFRQADNTILLCTDLLARGLDIPEVEWVLQWEPPTNPASLVHRVGRTARGGAAGCSLLPLLPTEDTYVPFIKTNQMVELKDWRKSKDEIKINPKLKDKVLSMLHEQQKQDRAVLDKGLRAFVSHMRAYTKHECNLLLQFKELPLGHIATSYGLLKLPLMPEIKQEHKDQFVGPKEEIDFNSIPYKDKQKEASRLQKLGEFKKTGVWPSKKKKKMVQSEPWEQAKLNKEERKQKRKKRKELKKNEPEGGKKRKRKAVTQEELNELAADIALMKKLKKRKITEEQFDQQFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUG5</accession>
    <name>A0A835GUG5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUG5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="232" mass="27155" checksum="72691D28610B546A" modified="2021-09-29" version="1">MKIDTERVIIEVHLRPVLWDKRNELYKNRDAREAAWRDILKELAPNYENLSEEERKEADKKIQQRWRTARDTYQKDKLSEKNQPSGSGSKKKKKYSYYDILTFLDSTTETAGEESLCEEMSEQSNLETPNESTQPGTSRQDSSQLTSQRNLETRNESTQPDTSRQESSHPTSKQKQVKSKKQAPSEFEAQLLECLKSNQLELESEDLAFFQSLQPSLKRFTRYQKLCSEQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUQ8</accession>
    <name>A0A835GUQ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/potassium-transporting ATPase subunit beta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9423455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32392" checksum="C82ABA8CF4CF0A6B" modified="2021-09-29" version="1">MGLEKRTIKIILIVAAVVLVIGAIIGLLLGLLLPQRYVELEVWPRSEEYNWEQPLIQVRGNDPGSWHIWYRRLNDFLRVYETSIPEDPPRAPCSVHNRRDQHLRSDACDMAMRLWHPCTADDFYGYAMGKPCIFLRLSHIHYWVPEPYNMTMPMSIPPDMPQHIREAMRHRPANQYGDFVWVSCGGEFSADKENIGPIQYIPAEYPPGFPLSRLHTADRIPYSARNMPDQVPGPLIAVHFENPRRGVVINVECRIWTRDILYDPKSRYGRARFELFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KW96</accession>
    <name>A0A835KW96_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="3">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_014183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000892">
        <property type="protein sequence ID" value="KAF9404762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KW96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052960">
        <property type="entry name" value="GlcN6P_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009022">
        <property type="entry name" value="PRK12358.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42892">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE DEAMINASE-LIKE PROTEIN BT_0258-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42892:SF1">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9404762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="216" mass="24074" checksum="C09DCC04EB3D7E9A" modified="2021-09-29" version="1">MYQDKRVNLAITAGSTPVKMYEYLVDDVKDKTYFDNVHYYNFDEIPFMKKKGYGVTMTNLSKLFFDPAGIDTEHIHPLDQDNYQSQDLRIKQDGGLDLILLGIGADGHYCGNLPGTTTFENETSLVDENATPNMKDVLLNEVGGDEAERPSFYVTMGPKSVMQAKEIVLFATGKKKARIIKQAFFGPVTNDVPASLLQTHPNLTIVLDKEAAAEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXM3</accession>
    <name>A0A835KXM3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000802">
        <property type="protein sequence ID" value="KAF9405149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032928665" description="Cuticular protein RR-2" evidence="5">
        <location>
            <begin position="30"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116711" checksum="0046C898141DD526" modified="2021-09-29" version="1">MSTQTSFITNTMFIKIICVLSVAIVVVSAHGHSSQFVHKYDGHHEPVYHGHGHHDYYFGYKVDDDHTGDHKSQHEHRDGDVVKGHYSLHEPDGSVRDVHYHGDHHSGFHADVKHSTHHIVLCLLSVAVAVVSAHGHSSQFVHKYDGHHQPVHHGHGHHDYYTHPKFEFGYKVDDDHTGDHKSQHEHRDGDVVKGHYSLHEPDGSVRDVHYYGDHHSGFHADVLCLLSVAVAVVSGHGHSSQFVHKYDGHHVPVHHGHGHHDYYTHPKFEFGYKVDDDHTGDHKSQHEHRDGDVVKGHYSLHEPDGSVRDVHYHGDHHSGFHADVVLIATVLVAATAQSQGGHDLHHSHASSSQSIKQHHGKATEKHVEYYSHPKYEFAYKVEDPHTDKKYQHEARDGDVVKGVYSLHEPDGTVRIVEYHADKKTGFNANVLCVLSVGVAMVSAHGTSSQYVHKEDGKHEVVHHGHDHHDYYTHPKFEFKYKVDDDHTGDHKSQHEHRDGDVVKGHYSLHEPDGSVRDVHYHGDHHSGSFIFFIHKNLAVINMFCRSPSHYHDHDDHDEHHGHELHHEHEIHHEHEVQHGHHEHKVEHNVEHKVEPKKEHKVEPKKEHKDDHKVQPEKEHKIEHSVEHKVEHFVEHKIEHKVEPKKDHKVEPKKEQRPDPKKEQKVEPKNVEYKPARIIPVVEKHVEIIPVAAASKIVPVAHYVQSANKKESHEEHKHAISSQHISRHDIPAQPPKDFDDQSGPAKYEFEYQVKDPHTGDQKYQHEHRDGHKVKGVYSLHEADGSIRTVEYAADKHAGYIVALSAVLAVSAAGLLPAAHYSPAGAVSSQSIVRHDEAHPAAHVAHVAAPVHYAASPVHYAAAPVHYAAPVAKQESRDGDAVHGEYSLVEADGSVRRVQYTADDHNGFNAVVSNSAPAHHAPAPVAHAVHAAPTHSIIAWISFARTRERNLVVVSEVHGGGVHGVRDWGGRVVSGSGVGDHRVEAVVVVGGVLHAAHGAVSLHHRVLAVHSVTVAGLLLGLVVAGVSVSHGVREVVFGVSLKQTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZE9</accession>
    <name>A0A835KZE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000488">
        <property type="protein sequence ID" value="KAF9407284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="168"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="272"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="421" mass="48979" checksum="78A555702EC55980" modified="2021-09-29" version="1">MEYSNMDARKERKVLTKKLLEEAVQNLDDLSDLSGSDSEDDSCFINSIHSPSDSYLNQIDDNLIEQCLEHIFGFGLTGDEQEPSTPPMQTQQMSTDALLTVLDETSHFTNTPKTDNRLLPTHLESETNNEVRRDRSQPRVWEIKSETHEVPLFEKRFKPKANDTHKTSPLSIFERLFPDELMVIIVEQTNRYARQKSSTNWKPVTLQDIKAYLGVLILMGLNPLPDMELYWSSDPFYYNKKPPFNDNDMKPPRNSPEYDKLFKLRPLLTELNKEVTVLTTAHQPLDTRMIKRTQKDGSRADILYPAAIASYTLSMGGVDLFDHFRSSYPINRKSRKYWMRLFFFLFDASIINAYITYNYSRVPTLHGHRDFRLRRELVFGSGKLNYIKYHHYNNLYQPQYIIKVVAPGLPVPIANICAIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZT3</accession>
    <name>A0A835KZT3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000261">
        <property type="protein sequence ID" value="KAF9410480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZT3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="98" mass="11582" checksum="411C0C3C8E4772F5" modified="2021-09-29" version="1">MSRHQRTLDAKAARRNLKKRLDLNTWREELARRDDNINHLQPHVAPTRTETVTSAVTKKQMPPRPLKTPMSAGQDTLDIWTVRNNLRSRYDLNTWRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0F8</accession>
    <name>A0A835L0F8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000503">
        <property type="protein sequence ID" value="KAF9407133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="23156" checksum="0A06C18EBB30EC2D" modified="2021-09-29" version="1">MMPKYVFHYFPIKALGESVRLLLAYGEEGFEDHRIPLEDWPKFKPNTPFGQMPVIEFDGKQYAQSIAIARYLGNKYGLAGDTLEDKLEIDQNVYLINDLRTKAASANYEKDEVIKEQKYKEFSEGVFPDYLERINALIIKNNGYIALGKLTWADFMFAGLFDYLGAMMRMPDLGKRYPALQQVVDRVYSFPSVKAYADAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1C8</accession>
    <name>A0A835L1C8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000372">
        <property type="protein sequence ID" value="KAF9408626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1C8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="237"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="695" mass="76890" checksum="052810024A3E5863" modified="2021-09-29" version="1">MELLIRSLTSEDAGVYQCFAQNPTSSASAWATLNVTGVSAAAPTGVQCWPAGARAVAVRWPKVNADVMAYTVQITTPGGTSLPGQPVIGIEEIISVAEPLTPYGFQVRAYIKSSSTNKNVASDMSESVMCQGQGVPIKLARQGDDILVSWKQFADQTPGVLQWILQYKAENSSDEHNVTLDKGVTNHTIKVPSEEPLQVRVLGTRMIPWLHQNLTLVPWTSTTIAIHAPDGGEVTAVPEDVEVTDVKAREFTVRWRCEESELSLETYTYMVCTRKVDGNEECIESRSKSIRIDKLSPSTEYEVRVQARIPARMAVGEFSKPIHIRTQAEGTKRFENLSYTMVNTSALRVSWNSLPDKYTIHYSNELTLPINQWPCVDTVGNTVVLTGLDLTKELYVMVTGYEPLGHSQILNIPVLVPEAKELQYWFTPTGVQVTWRGQGPRIVRYSQNLTQSLDLWHTINVTTNSVHISGLEPDLTTYVMVVAPGPSARNQVVNILPRPPDQSSYYLSIGIGCGVVLICLLAAAAVCIWRRRKRSHSPVRSRRRNLSSNDGNEEEGAEMKNIGNRLANGGGSKDAGEPLLNGHVHITENPNQSKTPNGRMRKGRRYEAAFDVARYEDPDTTLETVLDPDTSASTTFNLLDTSRRPEYEVSRSSRDLSANNSFNKLPDDNMNSELTRSTDFQLDNSKILPTLQPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1C9</accession>
    <name>A0A835L1C9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_016714</name>
        <name evidence="2" type="ORF">HW555_009962</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000136">
        <property type="protein sequence ID" value="KAH9643425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1C9"/>
    <dbReference type="OrthoDB" id="7384592at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9643425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="149" mass="17535" checksum="D7918B1D30083915" modified="2021-09-29" version="1">MLSKFIRFTYKSNVGLLLTRKVVPKIQNVRYADMIPATQYDVPFPRRLKFGCVIRQNWEIIPLFVTTGAALAFMFFCIVYAFQNKVDTVYTSRSRENISRTMDLRNPTVHKLIIINQKYPPWPEMQSVLDKMRMAEKRALMRLQTCAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L231</accession>
    <name>A0A835L231_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative ionotropic receptor ligand binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000751">
        <property type="protein sequence ID" value="KAF9405373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L231"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056198">
        <property type="entry name" value="LBD_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24061">
        <property type="entry name" value="LBD_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ionotropic receptor ligand binding" evidence="9">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9405373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="54500" checksum="B91541ADD5FBDC89" modified="2021-09-29" version="1">MSPGKEVEICDLDNKHLGVLHVDTFVAIPSANYFIIIIDSYTDFSFLASKLIRSRSWNPFAKFIILLFNYVQNDKINIEYVEKVLSCLFKYNAVNIVIAVPQARNFRNAIIYSWRPYDPPKYCGYFNETAKDRLVKTNLCERGMLKYNTLIFEDKIPHDMNGCVMEVLALQRQPFISESEQNASIEKVMIDRVLRRFKMKAHYHFLEEIRGERENVGEWNGALKQLSAKNGHLLLGGIFPDFDVHEDFETSTTYLAGCLYLGCPESCQNSSVAAYQTKLFDVLTRPSYDYQMKTVQELVDSGIKFGGFGVLRDLFYNSSDPFDNLIGEKWVSIENITEALIDVAVHRNFSVLCSRLELSHISAVTPQLSDTTGNYNYFTFPDNVFSVPIETIALRGFPFMLKFSTTITLFKQSGINEALRYQFKEFTERRRARQLRDLLKEKSDVSPLSAKHLQGGFFALFLGMLVAFSFLLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2F5</accession>
    <name>A0A835L2F5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000270">
        <property type="protein sequence ID" value="KAF9410288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2F5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032269197" evidence="1">
        <location>
            <begin position="16"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="24368" checksum="BC48BE5940F2ACE5" modified="2021-09-29" version="1">MIMVVVWLVARPTFGGEAPGYFSKYVNHATPARHTHYVNVPACDSFLSNTRVANNISAARVDQMLRSSARRSRGGMPKPLGRDVILNNPYRITDHLLETSQQQRSSGDEELRRHYNYARLKSEANTFHNATVARNLPAPHQPAGEDAYLLPLLDIVSGRRAASRLPAAPGDLTTYSTRNLGSHSTDIEKDFADLKNFQKRKAAKRDLTFPLILPLQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L370</accession>
    <name>A0A835L370_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_007501</name>
        <name evidence="18" type="ORF">HW555_008697</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000880">
        <property type="protein sequence ID" value="KAH9629016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L370"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032610351" description="Multiple inositol polyphosphate phosphatase 1" evidence="17">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="56"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="200"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="402"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9629016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="433" mass="49252" checksum="BA8E3A492ECD345A" modified="2021-09-29" version="1">MKLLLLLIVALCSLQSVISVYCYWNTGCPYKYFSNKTPYNSVRGDIRDSVIKLTGCEAVSIWSLTRHGQRNPGPDYGSSMKDALVIRDYVSLAYKKGNSSLCAQDIENLQNWHFNKDLFDKPYQLTKEGFLESQGIARRLRQTFSKLLGNLESNDYLFRPAPGAWMEESVKGFVQGISSKPLTIQPPSPGLDILAPYESCPKYLKEVKYNPETYAPSAKYQSSSEYLAAKDRMQRRLGIDYSLTPTNITALYDLCRYTSSGNTFSPWCALFTTEDLKVMEYVADLRHYYKSGYGTPMTKLFGQIALTDLLKSFQEAKSGKGRKITGYISHATMMDMVYTALKLFKDDAPLSTSKRKLDRKWRSSKMSIFSTNFIAVLNKCNKGPDDYNVIFYLNEEPLQSICKEGVCTWKEFEDKLTPFVDTKTDFCNIDPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L382</accession>
    <name>A0A835L382_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">HW555_009745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000224">
        <property type="protein sequence ID" value="KAF9411450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L382"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9411450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="371" mass="43005" checksum="DFA9E9F973C001E7" modified="2021-09-29" version="1">MIDLFMPFRAFLKFENVCTDNNVFRMHYKVTVIMLLVFTLLVTSKQFFGEPIHCMSDSEKDSDKDAINSYCWIYGTYTLKSRFVGVEGKHMAYPGVGPSKSEDDEQIKHTYYQWVCFVLLGQSVMFYTPRYLWKIWEGGRLKALASDLSSPLVTKDWSEFRRGELVSYLSYTNIHTHNMYALRYAFCEILNLVNVVGQIFLLDIFLGGAFRNYGAAVAAFTHTPRVPANMIDFASVNPMDQFFPKLTKCWLRSYGPSGSLQIKDRLCVLPLNIVNEKIFVILWFWLIILAFVSTLSVLFRVLVLSLRPLRSLMIAGQLRYVKKSTISRIVKRFGYGDWFILYLLGKNMNPIIYKDLIVELSKELEHKTVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L467</accession>
    <name>A0A835L467_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000381">
        <property type="protein sequence ID" value="KAF9408456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L467"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="515" mass="58036" checksum="EC236230AFD1A833" modified="2021-09-29" version="1">MSKPEQLSSEQVLLLSDLLSKITTTMSTKSFAQCRAKFNGERCYNKVEEFVTSISVFKKIEKISDDDALEGLSLVLTDKAATWWIGIKSEIKKWSQAIDAIRCAFAPRKQPHEIYMEVFAKKQGNENIDDFVCEKRALLAQLPTKRQKEEEHLDMVYGLLKISYKKEIARSDIKTFADLLERGRHLESLAKEGEETTKFTTERKPIRRCCCGKKGHTLEECRKRLADNKTTSTNIKPQNKLACYGCGTPGVVRSNCVTCKNQETPPKPVAFCTMQATLESNAKIPTIPISIKGETGYAYIDTAARTSIAGTQLYKKLIRHGTSFVERSADITLADGTIKTTTLLTAIVDVVIGERILPIAFSAIPEAKNNRTLLGIDFLESSGIVLNLPQRAWYFVDDPDKIFTILQLKNENIPLIATKSIDFNMESNTSLDVIQTTKLDNKNEEETLPDFIKWARELNMVSPMMETPSPVRDEDGSPGNKNPDGFFKNWTRHRAQYVQENQLMIILVLILALTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4H1</accession>
    <name>A0A835L4H1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4H1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="808" mass="93663" checksum="8B8A3871EDBF18B9" modified="2021-09-29" version="1" fragment="single">AERKHNNMAPRKKKLSREELLQKKREAERLRYEKRKNDPQKREEMREKEKLKYQKKKEKGSRKLVKPKKNTSAALKKWKEHCTVYRTKRLRLKSVTNTFIRDNTPISDLEASPPPTRPTTPIPEQFSSAPSPAASSASQQQRKKEATTRRKKFNRKRNEKIARLEKKLEKYKKRLARFKSKMQKNVEDTPKTKILKMLEEPDQRKEVVKKALFGDVIRNQLKENYSTLKHTKERQIFKKVVTGSLVRKYRQWIPKEIKSLSRPGKKSNLNGLDVPVLKRCKIPESYKRAVHNFFEDDSNSRMGAGKKEFITRKTVKKQKRYLLDTVMNLYKKFITGNFKISYQTFCRLRPFWVVKPNAQNRDTCLCIVHSNIDMKLSTLHTANILGYNNHQKLLEELCCDRYNVNCLARSCHTCLNKNPKYKEFDNRNVIKYKMWISERQQIQDFKTKKPRLVTKCLKKTFEVHPRQLITQLQKDLDKFFEHQRNIVHQYKAIKDLKSNLHYDEVLIHVDFSENYCTKYSEEIQAFHFGGSRAQLSLHTVVVYLQNSILSFCTVSENITHSPAAIWTHLRPVFRALPCNIKRVHFLSDGPVTQYRNKTMFFIMATKLSEEIPDIENFTWNYTESGHGKGAPDGIGATCKRTADFVVSSGGDINNIDQFVTVIQERCLGITCIAIDGKDIQAMVDTVEEEAADQKGFKGTLNVHQVAGVYSSSIPGLPTKCKTLTMKTLSCFCNRGSCEHYKIGSINFALKPKLTVEEVFTESEAEDLEPAKSELTPTQTKSLQRLDDAIPGTSGIQNSFYNTGDFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4V1</accession>
    <name>A0A835L4V1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="74" mass="8262" checksum="1526E707C4E6EB81" modified="2021-09-29" version="1">MRIFHCLGKNRGYFCTPVKKLIGSNAAVKKKRTCRYDCTELCQLQGTGHGTCQGSICKCSSLNTIVEHINEHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Y7</accession>
    <name>A0A835L4Y7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Y7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033008169" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="167" mass="18460" checksum="AA0BCC4D8E76954B" modified="2021-09-29" version="1">MRKMFKVWIVAVVFAIVLSAVYSHVTPSEQCPGESFEDLQERIQVTPCGKTRCKLPKNTNITVVFKFTPKKVVKSITNEVFANIAGVPLPFIGVDGTDACGNVKRADTQEAVACPLPADQDYVYTNVFPVQPFYPAVNLRVHWNLKDGKKSLICFEVPAVITAGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5C3</accession>
    <name>A0A835L5C3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="289" mass="32993" checksum="E848D06C9E0E233D" modified="2021-09-29" version="1">MASRDRTNEFISAVRSLQGRTLARPIIRDERKAQILETYSQFMGMAKVISKNITSTYAKLEKLALLAKKKSLFDDRPTEIQELTYIIKGDLSSLNQQIARLGEMPRGRRSMHSHSSSVVLALQSRLASMSNQFKQVLEVRSENLKHQNNRREQFSRVAPLVKEVPSLLQQDDISIDLGDAPNIQTQQQQLALRDDTDTYVQQRAETMHNIESTIVELGGIFQQLAHMVKEQDEAIGRIDANIQEAEMNVEAGHREIMKYFQSVTGNRALMFKVFGVLIFFFIFFVVVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5G8</accession>
    <name>A0A835L5G8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5G8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033349">
        <property type="entry name" value="ATRIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594:SF1">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="801" mass="91316" checksum="67239CDD32537AE7" modified="2021-09-29" version="1">MSKRFYPQSHGERKKAKLDISISDHNFPLSQNNEFNQVTNNDDNWGDDNDDEILLLASQACEQAYNSNDISQLPDYSMCMQPGSTSTQLSLHPTPSTSKSEFTFKKPSFNQPTAISTHLKEKCHRISSPLPGISSKVIPKTNGQVDMSDELIFSDKVFKSNDSDQVYRQLLQMQEENAKLKSENGKLLEKCVTKEGEASILRTQLKSCQAAVDNARLEKIKAQEKVQMEWNEKLTAANKQMHDLRTQLDFKNLEIISVKEKCKKLESSKVRLTQVTVSGNDISQRHYSNLTQNDMLVHHTKKVKTASNAVQTEGNAHMLKLNKTCKLESKMHTSILPYILEPSTTQHHSILDYNEKLQKATDLSQNKCRIYSTFHRLPSTPVLKETEKTKVVMNSIYEDVACVFTGDVQSIEDRYFNIFSSVKSVLYETRSRLETVCQRVTTAFQKEMDEKYMEVTASYQYVDREELLRGSPLFKEEQEIQSRRIVALLSYVLETTAGVHWFFKHERLRGETAEKIGQFVDIIYRICLLLDNASCATLYSGLLLAITNVLQILISSDISKTKVLEIIKIILTSRPLPFVMTHVLSLLNTVALWDDFMKTFCPGNGTGNLKTDYDQGVLLYKKDSCFIQVLLKQIEMCLKCMERQRLADRVVETTQNLIILYSNVSDNTNCSLAKESSRCDCQLVLIQVIVYALRICAVMLHSFRNNSIEDSSEELVSACRCGIQLLYQCAVRDVEFSAQLAHNEGHLIEFCELMRGVDHSEAYTNMLSELASTLQSTPEDMPPSFHRQPWLKSFESFSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5R8</accession>
    <name>A0A835L5R8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5R8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="428" mass="47675" checksum="3DA30C4DA91DB3A3" modified="2021-09-29" version="1">MLPWVQVTLMLCAVGLLREIRPSEPFVSEFLLGEWRNITEEQLNRDVYPVGTYCYLGLLVVVFLITDFLRFKPVIVLSGLSGIAVYAILLWTTSLEWLQASQFFYGLYMATEVAYYTYIYAKVDPAKYPRVSSYTRIAALTGRFLSGVSSQLLTHFGVMDYRDLNYITFAAQIMATFWALWLPTVQYGIYFHRKTSTGNPPLDKDLHPPNGHLLRSNMVEASTLIARHARSAYTRPKVLAWSALYAVALALFVQAQIYMQLLWKQIQEDTDSPVAYNGAVEAVQTLLGAGGAFIASMYSSAGVPAPVAAVQGVAVFLATFVNNVFVSYAGYIVMGMLFHYSITLASAKIAGQLSDESCFGLIFGINTLIGTGLQSILTLVLIQTLKLPIASQYFAISGLYLLLASIWLLGWMINMCRQKRSINVDNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6C6</accession>
    <name>A0A835L6C6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6C6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9415964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="37211" checksum="03F559D42D2F3F14" modified="2021-09-29" version="1">MGLYKLFSYNVEVQYMSCFLSKATLFTLTTTVLNFILPFIIAYRGRGFWLRSHSFYEQPVVQFTYEYLLIAETDDPTESIQCGATNDSFGDFMKNEENCVEFQVQEYDVTGDTNNDLLDFKFFLNVPQDRTVTSLILMLALNFQLKLVCPLQMQSLAVVNKEFTTPPSGFKYLADLEFYQTRHLPCKQNLVDTKYNSSVFIYDKNKSGNTIDQILEKYYMREVTTHTKSLYSRSQNGHTGSVQIQVSVRVPEMEVKYTPSLIQEIKWAWPQYLSLVVVFYWIFNRIKKFVFNNRLVMAWEILPWKKQQIATKKKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6V6</accession>
    <name>A0A835L6V6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6V6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032924573" evidence="1">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="274" mass="31209" checksum="1D225F493155F0A8" modified="2021-09-29" version="1">MFLNKSLFLVFTAFVLCESGFDFMFLFINDEFSFSVEQLPKCKLNDDNCKKGLIQTVLKILAKTGLPEKGIPKLDPLSVSNESFKIADVIDLTLVDGVVKGIKDCTVNRFTASIEDERATIELTCDVTIKGRYKVFSDSPLVKTFSGGDTVKGEGNGKVKIEKMFLRFDFDYFFQDRDGEIYVKCKNDKLKYQYDIKGKMLFFADNLFVGGKESSKVVMDAMNQNWKFLMSSFGKPFMDHAMDFVIKSIHTFFDSVPAKYMFADDLTEHARKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7G3</accession>
    <name>A0A835L7G3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">trypsin</fullName>
            <ecNumber evidence="11">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_004570</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="227"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="459"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1118"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1239"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="990"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1143"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="991"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1151"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9418742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142288" checksum="B7A1009C903AC042" modified="2021-09-29" version="1">MREDSDWQWRVVLGTSFRNGVGGSVHTIQRVIMHPQYIHKILNNDVAIVRFSAPAVFSNTVQQARIPGTQYNLADGSLVTHIGWGRQWTNGPLSEQLLHVHVNVINQEVCAARYAYLKTQPRYEEWPDINEGMLCSGILDVGGKDACQGDSGGPLAHHGDIIVGVTSWGFNCADPFYPGVSARVTQYTDWIIKNKFSSVSCILNMRAIILLALLGSALAAPNNPSRIVGGSATTIQTYPYMSNMQFLWWGFFWAQTCGGSLLTPHSVLSAAHCFYGDEASQWRVVLGSTWASSGGSAHLVSRLVLHPQYDRATLDHDIAIVHLSNPAVYSSSVQPASIAGANYNLADGTAVTHIGWGAIWADGPSSQQLMHVDVNIINQKLCAARYAHLKTQPNFENWPDITDNMLCAGILDVGGKDACQGDSGGPLAHNNNVIVGVISWGYECADPFYPAVPTNPNRIVGGSATNIQTYPYMSNMQFRVFDILWTQACGGSLLTPTAVLSAAHCFYGDQASQWRVILGSSLSNSGGTTHAVSQLVLHPQYVNAVLENDVAIVRLNNAAIYSINVQPAKIAGANYDLADGTTVTHIGWGTLWSGGPSSQQLMEVDVKIINQELCAERYAYLKTQPGYAGWPDITDNMLCAGILDIGGKDACQGDSGGPLAHNKDVIVGVTSWGFECAHSFYPGVNARISRFTSWIKATVNSLEYGHKQYLLPIPLKQKETQDQLEVLIDSSQGQAKIMGVIDRNHKSAQNILAICDDQLQTSSMVEGSINMALSTDHVPHMKGTPLNLSIEETEHDDKNNKTKTINNYGIRNKISQSEAVELVLNATSNKIPLFLVRDLDGNIIHIDTTDKDKSNWIGLLPLGDQNSANVWLYEENQELYAVTTKILPLRKPLKLGYSKQYSDAYGLIGSTKEIGKDTEVQKTWWCYECQRALPSEKQLKSHTESCHKDGALLPRRRYRCRHCTRTFSRLFVLRRHTSLHCPVKLEKRNKVSNQDPKNDGPQININTSINPEDNRIPSDESFQNYSNGLDFSTNLFDTDRISSLDISGNTRSDNDFNPYAIGYKDENDLANDLEFTSKLENCRRTSKEISPKPEEQLIVPCPYCNEIIVKGNRRQHISKCPARMLTCECKKVFRNMKQFKEHMWSQHSNEKPVPSESENNEPAPETKPEGPPLYKCDQCQHTFKRRGMLVNHLWKIHNMISAQVPLERACATTLAGLALRAAKFRVEALDGGTRVCEPAMCSECPRQYVTRAKLLQHQRAHHPYLILPPTTKKGKSLLIEQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7I2</accession>
    <name>A0A835L7I2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7I2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="267" mass="30744" checksum="2B16B22DE25B9C0A" modified="2021-09-29" version="1">MFEGSDNNLLVARSSQKNNESRPHECEICHRRFKRKQHLKVHMNVHAKNDFTIWCSFCGEGFLSNDQFETHQCQLMSQDGDTQGEQSEQPPQLPSPQVFPPQEHKKENKYPAEYMDLGELAAIDSIQYLNVEEKSLPVPQRVFVCKFCSKPFKRKDHYKIHLNIHTGVKSFFCTECGKGFYRKDHLQKHMMVHTRLKPKKEVPALVPIHQVPKKSVVLPEITIHAPPSAKLRMPLQIKVPYQMVVSMDNGEQRAVTIDPQASNSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8N9</accession>
    <name>A0A835L8N9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8N9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="293" mass="31915" checksum="A4BA0A14ED7AEC5F" modified="2021-09-29" version="1">MSLINTPLCVLIRNSIIASSVPRMMTTRHNSYMAPFKESLKSAKNVVIITGDDISTESGVPIYGKSSFWRKYLTSSLATSGAFLTFPSLVWEFYHYRRETAAKADPNEAHKAIALFEEKHGKDKSITVITQGVDGLHSRANIKNLIELHGSLFKTRCIKCNDIMTNNDHPICEALANKGSPDSTATNSDIPENLLPHCNKSGCGGLLRPNIVWYGESLDPSLIKKAEAAISVCDLCIVVGSPSMLFPAAHYAPEAMANGAITAEFNNDTDTNSNFHYSFVGPCSTTLPEALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L936</accession>
    <name>A0A835L936_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Caspase-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L936"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="174"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="4">
        <location>
            <begin position="314"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="65407" checksum="1B7259F6621A913C" modified="2021-09-29" version="1">MENETEYYQSYPGIFFLSRKGKGKKKKKGKSGKRSNNNGDKQNEKSESETLESVEDPSNLTDENGSGLDETEDDSNKSVIYRANDGESADLNENRISIDAMMFAPPKYEKSPEKVKFVDNEDIETLESNVDKLQIEEESVFENEDTKYTLINTRALPKEATTYELEKFTKHAMIIFNQKEIDGHLPRLGTEKDVEALTRTFSNYGFEVTPHNNLTKDELFKELKTFSERDFTDYGCVAVAILTHGSNNGLLRAKDQQYSEIEVINHFKDSSKPTLVTKPKIIIIQACRGTKITQGLPVFHAGKIRKDVDEEDLEPYILPVESDLLILHSSYVGRASHRYELYGSWFIQTLCKKIDSLSPSQDLESILTEVKREVAIDKQHEEYNKRTFEMNVNKQMPVLTSTLIRKLFLKKYGEKGRKDTYFVEENPCDETAQNFLDIANTFEDGVEFNTSKDKMCKAISKHLMINARSSHTHPKTLTHIRRRLEKVIMDPVIMVLNCKLPVEEQPGLLVKHNDVYRGPSLDNQRRGLRVWTSSWSTESHLFHLFYNVLQYAAEANARYRVPQTACDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L941</accession>
    <name>A0A835L941_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division protein kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20 21 22">Mediator complex subunit cdk8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 23 24">Mediator of RNA polymerase II transcription subunit cdk8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">HW555_003617</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">BAW_Kor-Di-RS1</strain>
            <tissue evidence="29">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L941"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000088">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000122">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="11 25 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 25 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 26" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="374"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAF9420023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="463" mass="53390" checksum="35D351245766297D" modified="2021-09-29" version="1">MGDNFQNKTMAPVMMDYDFKVKTQNERSKVEDLFDFEGCKVGRGTYGHVYKARRKDGSDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKANKKSVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIRKMPEHATLVKDFKRSNYQNCSLSKYMDRHKIKPDSKAFSLLQRLLLMDPNRRITSEQAMQDPYFAEDPLPTQDVFAGCAIPYPKREFLTDDDQEDKSDSKARQNQQQQQPNTQQNQVQANSHDHGANNAKRMRMSGPNQGNNAGGGGQQEFHQQQQMMFGGQQQGGSSQQQGNFQQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAJ6</accession>
    <name>A0A835LAJ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide exchange factor DBS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAJ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="328"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="73244" checksum="EDBD19A7324C76F3" modified="2021-09-29" version="1">MKMETSGGSESSGGEDADARQARRGHVLAELLQTERVYVQELGSILTRLQKNNEGMEPYYQRPLFVKFTLHSWKSSSSNNDSYVRSLHSTLSCRKPNRCLKSNNITDNHHYSYAYASRLCNKNISSIHDKRKTQSLNRNQTFGNWSSTLQTLKKKTMFWKINQSLTQPSECKCLETIYEDYDRRLQDWCDTISHCTSLISGYKDEIEKPENQHLLPSGLVGQADVLFGNLHELFTFHQDIFLKDLEKSISATEFVALCFVEKRDTFFRLYSYYCQNIPRSERLRETLVDTHLFLQACQLRLGHKLPLAAYLLKPVQRITKYQLLLKLDLSQQGELLMQGSFLVVSENKRDLRLRIRPRRRHIFLYEKAMLFCKPATKNSHNKATYHFKHDLQMSQIGLTESVKGDVRKFEVWRQGRAEVHTLTAGSADVKRAWVERIKRPAKPSAVVPSATRTASCDTHDEPCWSTDPSDDDDDEPEHPPVTEAVGLNGTIHRMVQFFSVAGSAQATSTFYAVGCALVALSDYTAVGPSEVSLREGQHAELLKVGCAGWWYVVRVRAGRQRRTWTSARRPGRRVARTTGCTTTEPQRASPEHATLRSRTVTSLRPVLDSPDYRFQTKFCEVYAAFGNNTSFFLSSLSFGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAK3</accession>
    <name>A0A835LAK3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G protein alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAK3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26320" checksum="32B87864AB29C0F0" modified="2021-09-29" version="1">MIYDVVKCINRCFYQFQSDSVSYFFDELERIARPDYIPSHQDILHCRKATKGITECTININNVPFVFVDVGGQRTQRQKWTQCFDSVTSILFLVSSSEFDQVLSEDRKTNRLEEALNIFDTIVNNVNFKGISIILFLNKSDLLARKVASKETDIRWFYPQFAGDPHNLRDVQMFLLNMFANVRREPKTTLYHHFTTAIDTHNIEVVFNSVKDTILNRNLESLMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBE9</accession>
    <name>A0A835LBE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRISC and BRCA1-A complex member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mediator of RAP80 interactions and targeting subunit of 40 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">New component of the BRCA1-A complex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_005215</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BABAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21502">
        <property type="entry name" value="vWA_BABAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026126">
        <property type="entry name" value="BABAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15660:SF1">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9417801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="285" mass="32817" checksum="96AFAB9999A20209" modified="2021-09-29" version="1">MDTPDLLTPYISQSDSEPSSTPGSVPITITSSANEDFSELQEQVMENIQKPNVPNVNVPERIVLCLDVCFDNNKSLYRLGDGSTFTPINMMKRVIEFFLHSKSAINRKTEFAIIVLKDSEAVWIQNFTSNIKDILTTIEYLGPEECTSEIFDMKNIFNWIRQKVEIPEYKEGESTQPPPYVVRLLVFYVRSNCIPIIPQNEAYFSFLKKQLYFYIDILLAHEEECSVYKCEEVYDALQDLDNGYSYVFEVSRNATKIHDCIAKLLAHPLQRPLQKNTDYTFGAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBT3</accession>
    <name>A0A835LBT3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBT3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="219" mass="26131" checksum="CB52156610B1C022" modified="2021-09-29" version="1">MIRKRKRKNNLVFFGVEEIGKTERELVDYIKDTIEESGVQMNSQEISNIYRIGKQAENKNRPVVVSLTTQWKKHLILQNKSRFPSKIYVKEDYSKETLEKRKQLMSQLEEEKKKGNIAYLKHDKLIVKKPGDNSRDKRRREPSDSPDQTTQFKSDLAKKVTLWYPRENTRKPGRPKSRWSDDIRLTLGPFWTRVAEDRAQWRELEEAYAKRHAELRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC19</accession>
    <name>A0A835LC19_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC19"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="28632" checksum="50D6B00E0F535B61" modified="2021-09-29" version="1">MESISQSVSAMSSVFLQRMAAFEQELKKNPSAATSTSGLPAEFNAFRTFIILALNTLQQQVSLLAQNIDAIEMRSRRKMLLIHGVSESAEKDEDTPQVVVQVVKDYLKLNVAASDIKRCHRMGRASHKPRPILCKFHDMGLRNNIWLGKTKLKGSGVTVSEFLTKSRHTVFMSARDRFGVDQCWTREGIVYVLDLKGVRHRVLTMEDLNNVEPKHSDQQQQASGLSELGVVQPVTAAGSRVQIAAPKSKRNAARKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCE3</accession>
    <name>A0A835LCE3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein adipocyte-associated 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0359 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCE3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018781">
        <property type="entry name" value="TPRA1/CAND2/CAND8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10160">
        <property type="entry name" value="Tmemb_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39428" checksum="7449FCC078EA3CE8" modified="2021-09-29" version="1">MMYGTNGSDFPPVTEDTFCKYVLYYEINNSRVRIWDLIILIPNALFVLFLVVRFNKAQLKLRATSSPIFLTFYTLVWGNVIISLVRCAVSMTVNAAMPLGGLVDKVLWVMVRFFLLATEMSVVIFGLAFGTLEIVMPDDMFHVDTRDYDLFGHGGMLFWFTSSLVFALIYFLILLLPWIPLREYLALPTKLSFYLYVLLLALLDTTQAVGAGLLAWGNMQSGLCVVDVTTWLYFSLYTPLVYHTFLSEFFSVSQPSIMFSYKAQMDEPMDEDQVSLPHQQSFSSLKTDSDYIYQQSNSVYDSTLFEAGGTTPMNPVYSASLQSPDSIASGQSMEIGVPNSGFQSQNMPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0S0</accession>
    <name>A0A835G0S0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000763">
        <property type="protein sequence ID" value="KAF9405310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0S0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000111">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="255" mass="28097" checksum="E14F216FEA1FCD52" modified="2021-09-29" version="1" fragment="single">IGADGANSAVRKAMGVQYLSWNYDQMGVVATLNLAEECTNNTAWQRWIPSGPIAILPLDSKRSSLVWSTWQDHAKQLLKLPEDQFVDALNDALWKQYPRSSSVETVTSWTSSWLRRVGLPDGTSRQLPPSICSIAANSRAAFPLAFGHSTRYIAPGVALVGDAAHRVHPLAGQGVNLGFGDVSDLTKLLSDAMYSGLDITHSDWMSKYESTRQRHNVPTQVMIEMLHRLYTVDLMPVVLARSVGLQLTNALQPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1U0</accession>
    <name>A0A835G1U0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000900">
        <property type="protein sequence ID" value="KAF9404720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1U0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16015">
        <property type="entry name" value="LTA_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050448">
        <property type="entry name" value="OpgB/LTA_synthase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47371">
        <property type="entry name" value="LIPOTEICHOIC ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47371:SF3">
        <property type="entry name" value="PHOSPHOGLYCEROL TRANSFERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="491" mass="54974" checksum="4F8768FA0C213616" modified="2021-09-29" version="1">MDERPVRARVAVSVSLLSALFFTANLTLAETARPQLLGRQFSRDYIVKFLGLNAFTVYDGITTYQTNQVRAEASENDMDTVADYVNNHYAAPNPDTFGIAKGKNVIYIHLESFQQFLIDYKLKDETGVEHEVTPFINSIYHNNSTYSFDNFFHQVGQGKTSDAETMFENSLFGLDQGSLFTQVGGKNTFEAAPAILNQEAGYTSAVFHGNTVSNHYPYSQFTNDEAGFPIANTSDETINGYFATANYLDKSVEEFFNYLKASGLYENSVIVLYGDHYGISNSRNKNLAELVGKDKSTWTDYDNSAMQRVPYMVHIPGQSNGGINHTYGGQIDALPTLLHLLGIDTKNYIQMGQDLFSKSNEQVVAFRNGNVVSPKYTVLGSSIYETATGRLIVEPTEQENQEIQALKDKANLQLQMSDQTTNGDLLRFYTNSGLSPVDPDDYNYKDQLEQLQKIEKDKGKDSTSVYSKNNNTSTVDKYHTESFQDYLKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2W5</accession>
    <name>A0A835G2W5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000653">
        <property type="protein sequence ID" value="KAF9406004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2W5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="19186" checksum="2D0B640F9546FF9D" modified="2021-09-29" version="1">MNAIVVDWSAGNSGLNLVRAVQNTILSGASVARFILWLNSITGANLSQYHVVGYSLGGHQAGAVGRNLGGMVAYITALDPARPLFENNPDKFASTDAVYTEVIHTNGGGLGYLEPLGDVDFYPNGGVKMAGCLTSLVFHYFAESIRGGVFTGRKCKSYRHAVNGDCPSEDTLLMGGVKPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G486</accession>
    <name>A0A835G486_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_014178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000890">
        <property type="protein sequence ID" value="KAF9404769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G486"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9404769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="567" mass="66235" checksum="CAE3E45DF8176BD6" modified="2021-09-29" version="1">MVMSEIWNLSTLCRCCHADGHFKSLNLTYQGKKCVEIYENMLKDTLGITISSVYVKILESTYFVVNLEASYTICEECIDKLRDATDFKAQVQTCEQKFKEYCENEQFFSHPEVKVEDDLENSSCHSNDDDDDDNNSIIDHSTTNIKEELMIKIDKTENFEDLKEATVNQIIDEYIIKEKIGKKSKYSCKECGATFANIKIMNKHLSGHRNMVYKCENCPKVVKSHQMLLKHLEIHKNSDKDLQCSLCPRTFSKKEILDAHIQVHMSQKTQPICDMCKKIFTTKGTLIRHLRVHSGTNKSILCEICGWGFNDKTNLNNHINTVHRKLKPFECHICNKRFPTRRSHREHTNRHLRNKELYSCSSCDWKTHSEKKAQTHTLKHENKYMCRICPEIFDDPKSRKSHGYTKHCSKYKCTVCGACLANQYTLERHLECHKGVKRFSCSVCGEKFLQKATLIRHSLRKHKPDVLVDVGKTKCKICKRSYMNIGEHLKRHQIRNFACDICGQAYATKSTLNRHKQQKHFGRCFYCGICNKKYMQKSKMYTHMFKVHKVENKGKEIDQVENDVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4B1</accession>
    <name>A0A835G4B1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2 13">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_014143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2 13"/>
    <dbReference type="EMBL" id="JACKWZ010000867">
        <property type="protein sequence ID" value="KAF9404857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4B1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000008">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="217"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9404857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="828" mass="93598" checksum="7C0CCE693F272019" modified="2021-09-29" version="1">MQKLVEEGLVDHVLGVGIIVKGISISDAHEIYAIRKSLDVLATITAMKEMAMDDFKELKDLLEETETLNERNEIDQKWKNIYMKQQNKAFAAQLFGRWALEALVFEASLYPKPGLVDPKSNGAHADMNYQTFRQSCDALAPFLIDYTQLGLNHKGTATQLFEKVRKHGQLAEKSMLAQTNGVNTHKGANFSFALLLSAADLEEILHSAQKGKQLSLNVLRFSKTQDSIKECMDISAAIGVATHLIREIIPKKVQLNISIQENLGTAKLEEIDLQSLIYNLITNAYQATRENQGKSQKIQVKVTPATKETIELIKKTNHPLQKLNHFVTLEISDNGPGIPEKLKEQIFEPFFTTKAGLFAKMANVTADGIGAKTAFYYLPNAFLREFIAIVVMNKKRHLMMWEGRKTMTNIIDELEWRGAINQQTDSEGLRKYVETESISLYCGVDPTGDSMHIGHLIPFMMLKRFQAFGHHPYILIGGATGTIGDPSGRTSERQLQTMDTVQHNVDSLTRQMEKLFEVENDNRLTLVNNYDWTHNLSLLDFLRDIGKFFNVNTMLAKDIVASRLDTGISFTEFTYQILQSMDFLHLFQNHNVRMQIGGADQWGNITAGLDLIRKKEGAEAKAFGLTIPLMLKADGTKFGKTAGGAVWLDPEKTTPYEFYQFWVNQDDRDVIKYLKFFTFLTKEEIDALEVKVQTEPHLREAQRVLAAEMTKFVHSKEDLNDALAISEALFSGNVSKLTSKQIEEGFKNMPTVETQSLNQNLVDWLIELNIEPSKRQAREDITNGAISINGEKIKELDFEVTSEQTFDGKFIIVRKGKKKYTLVKVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4B8</accession>
    <name>A0A835G4B8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4B8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="609" mass="69602" checksum="CCE9151196849FC3" modified="2021-09-29" version="1">MDKFLTSSKSSTSRQEERGDINNDCDSSSTMREEPLPKKQKQQRDFNENWLTNTTFKNWISKREQECGTITAYCKVCNCTVLNHKPALVKHMNTAKHVQNISSKSQTIPIQQMLKPKPEDELRKRAELKICAFLAHHNLSFSLMDDLIPFLKNTFTDSNTIKSISLGRTKATNTIKTVLGPILTQELIDKLKKTPFSIIMDETTDISVKKQCALAVIYYDEVDCVRTQFLDIYEVKSGKAEDLCNSLLTWLEDRQIPLKNFVGFASDTTNSMVGEHHSVFSHLKQKVPHIACIKCSCHMIHLVASKACLKLPRSVEDFLRSIGAHFSRSTKRQNKLKEFQDFFGVDIHKILSPATTRWLSLEACVNRTLEQYQTTDAYKIEYANPRFFLPLEKIYIGVAAQASIDEFSREIPPTQIADFRKTCLSFYIEALAQIRKRFSFEDPLFDLLENVLNPIKAQKFEVKDLSCVIKRFPNIIIPDTENLHKEWKKHAFLDFSELNMSPDLPVEEYWNKILKMTDGTGEPMFPNLKEIIKVLLVLPFSNACVERVFSQLKLIKSDQRNRLNTDTIAALMATKAAVKNATTFEPSKALMHAKIKCNTDGDGDGEGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Q0</accession>
    <name>A0A835G4Q0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_016153</name>
        <name evidence="2" type="ORF">HW555_013785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000723">
        <property type="protein sequence ID" value="KAF9405520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000449">
        <property type="protein sequence ID" value="KAH9637131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Q0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9637131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="15052" checksum="E6C9BB7ECA8EA50D" modified="2021-09-29" version="1">MPYVMVIGSVSVAHLSNDEGATVYGLNTEERNLFIDQLNKSYGHQVAWLTSSQKDVQVRLKGLTLVVVNRIHALFGYDVVSHAMTMTNANRELVSFTMYKKTSASSQSQRHSHSQVHATGHSHSPRNSQEPQQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4U3</accession>
    <name>A0A835G4U3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBM48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000367">
        <property type="protein sequence ID" value="KAF9408703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4U3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="306" mass="35133" checksum="E63E341A946D41CF" modified="2021-09-29" version="1">MEKQVIMSEDSKEVELPPHHEQQTLCATRLPYRQGRKLTAVKAYSINNESKHLLVFGVPALNLRQETKALFSRFGRLQFNLTKYPAEQFTETYHANFDDIQSARIAKKKLDAKNYYGGNLHISYAPEFETLEETRLKLLLRKQNILGRLRNLDKATATVTTEAKIMPEASEKETQDIVHKEKVFMGDLNVICDQNNSSKRKVTDYKMVKHCKLKKSKMFDRKLVSVTQNTGVVNTESENPATVSDKMESVKENPCEVVDCTSVETEVVTNINDSLNYNNFGKEIIRDVPQKPVNKIRFMLNKKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5J6</accession>
    <name>A0A835G5J6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000324">
        <property type="protein sequence ID" value="KAF9409324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5J6"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20473" checksum="BDD769FB96073AD0" modified="2021-09-29" version="1">MYSVLTRGNAILTYTLSVLACLTFLCFLSTLTVDYRTAAQMNTVKVVVKNVPDYGASRERNDLGFLTFDLKTDLSHLFNWNVKQLFLYLTAEYITPNNELNQVVLWDKIILRGENAILDFKNMNTKYYFWDDGNGLKGHSNVTLTLSWNIIPNAGLLPNIQALGQHSFKFPTDYTQTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5R1</accession>
    <name>A0A835G5R1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5R1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="230" mass="25856" checksum="7B7D83A97C26FB71" modified="2021-09-29" version="1">MPQLDEVLSVTKTVEEKLMAKMEEVQAQIQCASTAKDTVAKIAEEFRTFRQLVYQMLGLLRNQIHECDVVVRVVEAEGEDCGKLILDLLNHKLSLCLEQSSIKSCHRLGGINKDHCRPILVHFNTIQTKASVWRLKTKLKGSPVSKKEFLTRCRQAVFGRARQHFGMRSCWTQDCIITIKTADGKRHKVTSMDDLNALITRFPRNTRASPVDSSTGSSEVKAGGSLKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6B1</accession>
    <name>A0A835G6B1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000380">
        <property type="protein sequence ID" value="KAF9408471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6B1"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF230">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="93"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="306" mass="35311" checksum="0E6CB593CDDF4135" modified="2021-09-29" version="1">MTLEQPAGEMWQKIREELNEKADTKDADLAHIKEWLKKEPHLPDEFDDQRIMTFLRGCKFSLEKTKRKLDMYFTMRAAVPEFFNDRDVNRPELQEILNMVQMPPLPGLTPEGRRVIVMRGVDKDIQTPNVADAFKLALMLGDVRLAEEKEGVAGDVYVLDASVATPTHFAKFTPTLVKKFLVCVQEAYPVKLKEVHVINVSPLVDKIVNFVKPFIKDKIKERIFLHTDTNDLYKYVPKEMLPQEYGGNAGPMNDLHNAWVKKLDEYKDWFAEQENLKANEALRPGKPTNYDELFGIDGSFRQLVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6G6</accession>
    <name>A0A835G6G6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6G6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="850" mass="95910" checksum="D34B4CA213EBF20D" modified="2021-09-29" version="1">MASSPSKLFPKPVVSRRMSSDMVENLRRQLMRDNYDYQNVNSNERGHQNSSVRINMACGVSNNSTFLSTLIPPEELKQPQELEPLPQLGPPPQHETPEQRPRNQQQNQQQGHRSRFEQRKRNDRPQQTRATDWPHYLEPAAGVPPTDELDVRDYLPDQASDPPAPYDAMKVNQMQVAPVGQRNRNQKHRVEQHASYERKEIPTPREDQDEMINTPPENEPGRNPEEADQPEQKNEREVQADLNHQDDAEPKEHSEPQDNLDQQNDQASDFSDAKHQDQAIFDEIPGHSNNQPQHAGRTPGPPQQQKRDYQISKKDLLYYMDDTKLRRNNIASDDQSSTDDDESDQKKNNHTLDKNGHVKVSRSSNRVTSGRMAPSRNSRVYTKRTKVKSARRGLNTKSTTTLRPREKQTKRTFVVTVSGANVTYKLLTMKTHDRRRSGPRRFLEERAPDSRSLVALIALYHASILGQLHATATVQHTNAAATDKGSPKSSNKTIDFVNVIKEGLRRNNDDYEIFKHNMFLGKPTNGPPEVVRQTAEVPQIPNRIPVNWLPPPGHAEVRRPGPPAHGAGTIPRVVIRPEPQPLRRSGSARARPAPLIRQPVRGQPYRVQQKPLPLRPMNASRGINTTLNNSTAHSDNKTPNVTQFRSYTHSKHYKKVRVDKLKRLVDKEKMRMRIQSDRAGPEPLKKVGDQPTEKAKGGEVGVVTHATGGQTESTDTSATTPSASEMAQSTTPSILQMLATTHRSQHAKKYNWSDLGKLRHEKRLQSPSPDQLDMAPARGPSITLIRFKGRLCQRSVLNMEGPTYGKDGSVVMGPYNPENAKGRDFNNTTPANPLLPRCCNCCKKSVLGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6R4</accession>
    <name>A0A835G6R4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 5B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000395">
        <property type="protein sequence ID" value="KAF9408252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6R4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30560" checksum="087F067DF1A4E808" modified="2021-09-29" version="1">MGLLLSKIWSLFGNEEHKLLLVGLDNAGKTTILYQLLLGETVHTRPTIGSNVEEFVWKNLRFVMWDLGGQQSLRSAWNTYFTNSEFVIMVVDSTDRQRLSLCRDELHQMLKHEELTKACLLVYANKQDVKGSMTAAEISEQLELTSIKQHPWHIQACCGLTGEGLHLGLEWIANSTSVVLHLLPIGDSYIIWGALLVTMVLANTWGCRHYLRSLDAATNSAAPTVISAGSSYVLSGVIGIALFEEASSMTWWVGAMLIVFGLALVAQPRTKKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7Q8</accession>
    <name>A0A835G7Q8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000306">
        <property type="protein sequence ID" value="KAF9409638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7Q8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="113" mass="12574" checksum="0AAABDE1DD282C54" modified="2021-09-29" version="1">MHANEMKHLNDRIHLNMPSDASRGKWKLRLKVCTGDTHTHPNPNFGRFEKQSAEVDAHNFSGNTHMSMNLTPKLVSGAEGECGVGLGPSFLIFILSNILTYSDIEDTCSKFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8D6</accession>
    <name>A0A835G8D6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_015686</name>
        <name evidence="5" type="ORF">HW555_011748</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000371">
        <property type="protein sequence ID" value="KAF9408634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000301">
        <property type="protein sequence ID" value="KAH9639835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8D6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF8">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC2-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9639835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="369" mass="40899" checksum="67B3026B06488218" modified="2021-09-29" version="1">MALWTWGANSHGQLGVGVANEQIEKPTRVELHLYHCKINQIACGGGHTLLLDNEGKLYSCGWNSKLQLARETEVHKFERTWALSGVTFTNIVGGWDFSCGVTDDQFLIVWGSNAYGQLGVPSTPKEYFSEIMKPIRLPINAVLVSMGLRHTAIVNSKGEVWTTGCGRHGQLGLGNSVLSSDRFQKVEGVGKISHIACGQNHTVAWCSDEKALYVWGDNKHGQLLLCSEKYRKIYTPNKIDIDVKQEVKKLLSGWTNVLLWLEDGSLLAWGRNNNGQLGTDKTVLPGTFTHVKLPEGREVQDVAVGSEHTICLATDNTLWAWGWNEHFNTAIDLGHQIVQPTLVPLEIEKDQKITQIYAGGAQNFIVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8L6</accession>
    <name>A0A835G8L6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000381">
        <property type="protein sequence ID" value="KAF9408457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8L6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12353">
        <property type="entry name" value="RRM2_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12354">
        <property type="entry name" value="RRM3_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000419">
        <property type="entry name" value="CLUMA_CG006354, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000317">
        <property type="entry name" value="Rox8, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="324" mass="35340" checksum="686507B2F928E8B2" modified="2021-09-29" version="1" fragment="single">MEQHYHIFVGDLSPEIETQSLRDAFAPFGEISDCRVVRDPQTLKSKGYGFVSFLKKSEAESAITSMNGQWLGSRSIRTNWATRKPPAPKNEINSKPLTFDEVYNQSSPTNCTVYCGGLTTGLTEELMQKTFQPFGTIQEIRVFKDKGYAFIRFSTKESATHAIVAVHNTDVNGQPVKCSWGKESGDPNNAQAQGQIPTAYSPFGATYTGGVPPTSYWYNTYPQQLGGFLQGVQGVQGYTYAGQAFAGYQQQYMGKEYNQWANANACSSMGGVQLPWALGAGVGGVGSVGGVAAMSQPPQVLHYPVQHFQVQPIGEDEWLAPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8W9</accession>
    <name>A0A835G8W9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_010763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000281">
        <property type="protein sequence ID" value="KAF9410046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8W9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9410046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="24125" checksum="96DF9F7CA3EE0992" modified="2021-09-29" version="1">MADIYKLIHPVKYFNDYLSRNIRPDGRGFHEQRNIKLNVNSIKAADASSVVKCGNTTVVCGIKLELATPKAEEPDMGFLVTNVELPALCSSKFRPVTLPTVTYDPETEEISVDTSVRTKLKVHGLPVASSFALYKHLQNTIVLADPSAYEEEMCGGIGANLILCYNKGFLCGSHKFGCCNLPKECEEMAFKIAKEKTQLVEEVVEVCIKNYELEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G986</accession>
    <name>A0A835G986_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chorion peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000199">
        <property type="protein sequence ID" value="KAF9412140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G986"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF109">
        <property type="entry name" value="CHORION PEROXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="843"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="859"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="131850" checksum="BA3C4CD2BAA6D136" modified="2021-09-29" version="1">MSGGNGEGLEGREEETQFPTASMMRQSPLMQNCPLRGAPKCPPASKRYRTHDGTCNNINRPRWGATMTPVQRFLPPSYSDGLQAARRSIFGSKLPSAREISSTIHEDRNAETIGVTHLLMQWGQFLDHDVTSSSQSRGFNGSVPRCCKDGGKDFVPKEFMHPECFPIPVPASDPFYGPRGVRCLDFVRSAPAPRDDCALGWREQLNQVSAYIDGSPLYGSSATKSDKLRLFRNGMLQYGRVQQRRPVLPPERRDELCRKGAVSTDCFKSGDARVNEHPGLVAAHIVWLRQHNRMAQELTHLNPHWSDEKIYQETRKIVGAMIQHITYREFLPIVLGSEVMHRFELELQKKGYFKGYNPKINPSPASSFGSAAFRFGHSLVQSSMVRFDRFHRPMSNNVSLHDELTNPSNIWSIGAVDRLLLGMLNQPIQKRDEFITGELTNHLFQTPHFDFGMDLAAINIQRGRDHGVPPYTSWREPCGLSTIEDFEDLLRVMPARAARKMKALYRHVDDIDLFTAGMAERPVVGGLVGPTFACIIAQQYENGGFESSFTPAQLQQIRRISFAQILCRTLDSIDTVQPFVFLSTDNPDNDRISCQNGLLNNFDLSPWVEIDEDAETDNDISKSEETTKKHLRKTTTTSKPSTTKRTAPKGALKPNKTKPDTNPITVNNMTIENLTKENLTDKLNLTELKKDNDSDELNLTLTLTNYITTTPKPNMTTKPTVTRRDVQIDDKLDFKNKSRRFDDFKMDSRRRPATKYDEYDYDDEEDTHQVQSVVINNVAHKRPQYNRPNRRPVITVTENIDKYTYLINYVPRPTESWRQSTRRHTTGRPMTDRDVVKVTYQTYDDTYRRPNKPYYYNRQDSQQNNYRYNRPTHTTKYNYPSSARSNDETVTPRNKVTDKPDVKTESTTDLYKLVTFGYVGTYKGEASTTEKKMSDEHIAAKEETEKEVTDRHKAETISKDFSTFDVNDDKNMKLSTFYVYETATKPYLQRPTRRNDEVPIQTNKYYYIRNVLHKYYDDDKSTPRPTNEDEMKEINHNTYDVADNQKIEERSAIDKMATLDEVEVKSKSQERHKNRIKPISSPAKTPSVAFQVIPSENSASHWAVYEENSDLPEQHKMPAIKTDPYALKEIPTPIAFNSFRRRRPGIGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAL3</accession>
    <name>A0A835GAL3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000275">
        <property type="protein sequence ID" value="KAF9410156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="35159" checksum="262BAC04227EBD06" modified="2021-09-29" version="1">MNFRECIAEQYTLYTWFDIMFFRLIGVIEKTNEILSSMVLYFLDIKEHTKKFIALFVKTTYRWFIHGQSQQPEPSTSTGSGTSRPRRGRPSGANRVPLTLEERRARNAQYERERREDFAAAQTELAEAAGCDPNTSTINLMAFVVTKLKKASEDLSIEEYQRINANLEAQIASCFERLGPEYVLSGDEDDVEADDSNTRKRKLSQETSRDEKRMRPGAEQVPVSGSGPMVSTTDLAEAEPSFSGTHSQLPSSFFPSPNSPEIELLTPSQFAHHTPPPLLQLDTALEQEIALRFSQDDLLQIYGALESEDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBF1</accession>
    <name>A0A835GBF1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000154">
        <property type="protein sequence ID" value="KAF9413581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBF1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="429" mass="50428" checksum="7681720B6B6A5D83" modified="2021-09-29" version="1">MHFIELNIVLSSCFYFTNALGIFGIHNEYKIYVQQLLSTLAYPDSSQTSTKWIEQPLDHFNETDTRIWKMRYYERLDLWKPKGPIYLFINGEGEASDVFLQTGILYDLAKETNGAMYLSEHRYYGKSNLAAWMKLLYPDLVDAALASSAPVLAKKNFYEYLERVNYDFEQYGSDGCTNRIKQVFQRYDELFKTSSGIAQLMEEEEICKDVDMTKPENKQIFFLDKASYFMYEAQYGNVDTINNFCEDVKKTFHIHSRMEDNVFMSKEENCFNYDFDEMIEQMRNIDWAMSWTYQTCTEFGYFPTTDSENQPFNNVPVELFYLMCRKAFGEQFDEQRIDEGIERSNDMYGGLQPNLTHVVFVNGELDPYSRLGVLEDVAYDAPAKIIPQASHCRDLFSDRSKDPEELKEARKYIKYLIKKWIGAGEYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC13</accession>
    <name>A0A835GC13_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000219">
        <property type="protein sequence ID" value="KAF9411621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC13"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="2">
        <location>
            <begin position="62"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="23503" checksum="D880EEF1BD43A5A1" modified="2021-09-29" version="1">MVKTKVQYARNTLLLIYIFVYGIRNGAPADEPYNSLHLNGNGNVGVGSRAPPWPVPRKVNEKMFLLPKQLEPHDTITINCETTSEPTRLTFGLVTGYDEPDSDNLACQLDMNFTESQNEDTSLQLTTVYQGNANVVFTDTAKSYFDDTNFEMKFILRTARDNGYVLDVHIGASYLSSVPLEHDVSSIKFITISGDIKKIAKLGFEFGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCC0</accession>
    <name>A0A835GCC0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCC0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="353"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="685"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="756" mass="86928" checksum="2DA2A9D5C982A69F" modified="2021-09-29" version="1">MPMIKCGGCGKFISPADAARCTKCNEHYHRVCVALTGRGALPSFWQCPECKKNVRRDNKSETPVRNSQAEVQSATAPLISAEAPVLRSATSEESAEEETDIGMCEPAGCVQESGVAMRNKPHDQQMDVASQLQSIMEELRSLRLEVLELRKEVRSSGDACNVRMDTIEARLQVLEERHAGYSRIPVYEGTRGNIVTVLFIKDLAFVDPDDNTPLRTLCQYYQNPCNFVFEDVTLDVMFKQFKEGHKGHMAFVHRINNEGEGDPFYETMGLVTLEDVIEEMIQAEIVDETDVFLDNRSKRRRNKPMNKLQDFTAFAERHENQRIHISPQLTLATFQFLSTSVDAFRPDTVSETVLRRLLKQDVIQHIKIKGKTKKDPSTYVFQQGKPVDYFVLILEGRVEVTVGRENLVFEAGPFTYFGVQALTQNVGVAESPTPSAMGSLQNINMDSMLRHTFVPDYSVRAVAELFYLTVKRSLYLAAKRATLMEKGALSKGATNEQFDTEVDKFPPRVNIIELMQLSQNYPSSERLETDSEKFLSKPNQYYAHSETSRPKMGVTTKSHIELTKTGPSKSYPNASDSRHWNFEKFAKINCDRPKSFTKEIDANDCAECIQNNFWIKKNVFNKSADDKLHDLDHHKKKKTTTFHTDSSLLTFHNLSPRSHEDIDLKSHPDIDLPNRDIDYKTELDYKSIQQEIEAHDRQLEHLDRYERFLEFEKDTIDYEREWKEERVQLEKRRIETEQLMLVQLSKIVKMLERNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCG9</accession>
    <name>A0A835GCG9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_001533</name>
        <name evidence="5" type="ORF">HW555_007599</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000853">
        <property type="protein sequence ID" value="KAH9629720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCG9"/>
    <dbReference type="SMR" id="A0A835GCG9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000540">
        <property type="entry name" value="RNA-binding protein Rsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9629720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="15958" checksum="7E92B5F2FE930F98" modified="2021-09-29" version="1">MSSGGTRVYVGGLVEGIKKEDLEREFDKYGKLNSVWVALNPPGFAFIEFENLQEAEDACSAMNGFEMLGATLKVEISRKRDGPRRGGGFRGGRGGNFRGRGFGGPPGGGNRSFNSYGGGRPYNRNNQRDEYGSGGGNFRSRSPLSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCR4</accession>
    <name>A0A835GCR4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="100" mass="11630" checksum="B3F3256B56FBE52F" modified="2021-09-29" version="1">MDEQLNNIQDIDINSPDFYERVQTEIEFDTARMKKNVEIIMNLRSAEIEVETAALFHAEIWYDMLDKPEDPDPDDDFLENDNDETSENQNTIEEDASAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCW6</accession>
    <name>A0A835GCW6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000168">
        <property type="protein sequence ID" value="KAF9413164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1337" mass="153162" checksum="EFF5C0A1DE7D4BA0" modified="2021-09-29" version="1">MADSPVASIVSEILRVEAVEEAFSCFLVHKPEEENEVLGMYQKRLSGIMTHLSTEMQESALRQYLTPTAVLTNRYKMKQLLGLLENLVNTNVIQARMLCDCILTNEKLTYQNADFWIESFNLIRRIIGGVDYKGVREIMKGCREKAHTLPVRLNSSTMPQLKALYNVIEYIFDRNASLLPAYFIVTEIQKDYPGNNHWPHWQLAKLLSSFVESFKPCAQMVSIIGHSQMLPVVEFSGYADHLVNPWRLDPTTLKFSLKGNLPYDEELLKPQISLLRHVLQQPYSRDMMCSMLGLQKQHKQRCIALEDQLVELMILPMERSEQENEDDEMSSSHWCWLHLSSQVIYLILIGFASFPNIVMGLHSKLIGHDMKKGRDHLMWVLLQFISGSIQRNPSSNFLPIIKLYELLYPEKEPLPVPDCTKAHCTHQMAVVCIWMHLLKKAETEHKTMSMPQNLKVQYEYLQHLFTSNNTPTLMGSDYRIALLCNAYSTNQEYFARPMGVIIETLFGSQKAMPNGNPTTPLPTVPLSMCILDSLTLHCKMSLIHSTVTHVAKLAQNKSNIPGNNMMAPALVETYSRLLVYTEIESMGIKGFIHQLLPNVFKSHAWGILHNLLDMFSYRIHHVQPHYRVTLLSNIHSLAAYPQANQTQLQLCFESTALRLITSLGSSGVQLQMSRVVSEPKSLVSSESEELNRVLVLTLARGIYMTGAGSDGAAVKELLTTIMTNTPHMWSQHTLQCFPPMLVEFFAQNPAPKENKQVLKKSVEEEYRKWTSMANDNDIISHFSVPGTPLFLCLLWKMIFETNRINPVAFKILERIGARALSAHLRKFCDYLVFEVTNPAGGPHINKCVDAINDIIWKYNIVTIDRLVLCLVLRPNPDGNESQVCLYIIQLLLLKGSELRNRAQDFVKENSPEHWKQNNWYDKHLAFHRKYPEKFAPEEASNAYGGPIPVYLSNVCLRFIPVLDIVVHRHLEIPSVSKNLEQLLEHLGYLYKFHDRPITFLYNTLHYYESKLRDKPLLKRKLVNAVLGSLKEVRPAGWATTEAFQAYLAKTDVEATAWTGPDLNYYLSLVNRMVDTMTGSSHFPNTDWRFNEYPNPSAHALYVTCVELMSLPLAPNFVGNTLLDVITKGFVVIPPTKIQLWINAIGLIMAALPDPYWTVLHDRILELITNNEMTEWPYPHTPFQLFNLTTTNDAMLENKYSLTLALAHAIWYHAGAGQIMQVPQFIKEKLSVEVHTEIQLLYLCHLVGPFLQRFNSDLSRAVMDITITLYELLAHIDKSQQHLQYIDPICDLLYHIKYMFVGDTMKNEVESVIRKLRPALQMRLRFITHLNVEQINTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD95</accession>
    <name>A0A835GD95_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="24654" checksum="52B059B94092FA22" modified="2021-09-29" version="1">MFVSVVNKRVARGIERERSAGEWRRAAAGRSVAARGAGGRAAVDYVRAMCWRQVSKLHKTLLVAVFYMAMYELVWYALGPTTEVTFIREDLHVGDKYAFIFLAVGPEWPVFSDAEGAQVFKSRGCGPCFITNNRGLLPMSEFDAVLVYGKRALLSESMAVMDPEKRFLLETYKRCMSSKLTHCIREPRVTSFINFEVLNLCELCDKLLKRRYNNATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDD0</accession>
    <name>A0A835GDD0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000199">
        <property type="protein sequence ID" value="KAF9412136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDD0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="35175" checksum="5E8CD605FB16432D" modified="2021-09-29" version="1">MYLLLLLKFQLTTSFDVRALVNGNRMGGVPLGLSLGAGELDVEGICTRPGMACQNCSHAVTCVPLPVGWLKVPLQECNEGLTCNAHQGQCSPDPAPECSGPAQVFEHTCEQVGIFPDAYDCRKFHLCSPPEGLPDGRPADHRAALCPRHYGYNPATAQCSIQLEHSQCSEKPVPECKVIGQHGVLPLSSNHYYVCLIKNGVLHPQVFICPHGWHFWGEFCQPEPEKKPTNAILDETVKIEQTTEDKIPEVEEKETTTEDTATVEATTTKIDSFFSTERTATYAADTFLADKIDLANYETTDDVGAPTNDNFGLSIEYDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDH2</accession>
    <name>A0A835GDH2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000197">
        <property type="protein sequence ID" value="KAF9412203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27085" checksum="00E65F46DE33DD3C" modified="2021-09-29" version="1">MSNNLQDDRIAAALLEENDTSSDDENFLPSSDDEADHISEASEVRSDTDVEDAENNLEPYLDGGSRKRRPKKAVYYNVYYNSTKSGVDVVDKLARTYDVTRNCKRWPLTVFFSMLNHAGINAFIVYILNNSIERKKTNLRKNFIKQLGLSLLEDHISKRKDNPHIPRNIRRRVHEMLHEEVPGPPPKQPRRSQRCSFCPRNKDRKTLNGCFKCNAAICKEHANLMCQNCTDLDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDT4</accession>
    <name>A0A835GDT4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCA tRNA nucleotidyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_006906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="80"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="11">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9415484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53836" checksum="F531E86F11BA9A10" modified="2021-09-29" version="1">MYTICLEIIKRGRYSPKRALSTLNKSRILRRSTRSKMDEELKSRENPVVLRLDSSEFQSIFTPEVITLKNIFDKYKYEIRIAGGAVRDLLIGLNPKDLDFATTATPQQMKEMFTSENIRMINANGERHGTITARINDKESFEVSTLRIDVLTDGRHAEVEFTTDWKLDANRRDLTINSMFLGFDGSVYDYFFGYEDLKKRRIVFVGDPDRRVKEDYLRIMRYFRFYGKIADKPDNHEENTLRVLKDNIIGLQNISGERIWVELKKMLQGNFAGNLLKTMIDVGVGKYIGLPVSPNVEELDRLVKRTEHLSLHPISYLAALLRDLDDVTVLYNRLKFSGYDRDLAYFLVEHRGDKEGSRPLLPYEKLVLNSKIKQKDAIEYVKEVLKYRGDKLFDQFNEWVVPRFPISGKVLKEAGVPPGKMYGPIISKIKDIWIESNYKLAEEELIKYIPGIIEEFDKNKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE28</accession>
    <name>A0A835GE28_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE28"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="271" mass="29943" checksum="E4F8675BDE57721C" modified="2021-09-29" version="1">MFYLIGLGLGDAKDITVKGLEIVKKCDKVLLEGYTSILTVGKEVLEEYYGRPLIIADRELCEGAIDDILLEAKESEVALLVVGDPLGATTHTDMLLRAKQFGVQTQIVHNASIMNAVSCCGLQLYNFGETVSIPYWTDKWKPDSFFDKVVGNFSRNLHTLCLLDIKVKEPTEESLTKKVRQYMDPKFMSVKEAANQLVQIIENHPDKGISKSSTAIGLSRVGASDQRIAVMTLDAMQNFDLGPPLHSLVIPAPNLHPLELDYLAQFNQSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE35</accession>
    <name>A0A835GE35_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome inhibitor PI31 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE35"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="281" mass="31012" checksum="FD7D4D269A714092" modified="2021-09-29" version="1">MADALFGWDLTFKTVEKDIKRKSDVIIAFIHWNLSKRGFRSIGIGDERTLSGDEDKSELLPTGWNDKENYALRYVLNNKLFILHGLSTDGNLIINLMRSEDLAVSNIAIKIEETVKDLCGPIDKIMPNHKELIYNVKRDLIDVVTERPTSSTETQTVRSESTTRRPPEDPLRVPPRPMPGVNPDTPDLWGMPPPRLPNIGSSDLDPFAPGGGGMLFNPFEPRRDLENPGLGIPGGLPRGAVPPGARFDPFGPPGGPMPGRRPAPPDADHLPPPGFNDNMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFH4</accession>
    <name>A0A835GFH4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFH4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22277" checksum="21AD21F7FE8FD90F" modified="2021-09-29" version="1">MSAVVLFGVSGFLIYKLFIYRHFIGVNVEYPAILLLMMAIITCSIAWIGWRTTKSMHQIHVIITGILILLVVVIEFSCFVWAMVVWDNVEIDIKSTLSHYFEHTLTKTDTTDVDIIRWDRIQVKFECCGVSGPSDYTSKGQVPFSCCGQGPLDSLHRPYAADCSMLYQRGCGKPLHDYARQQVLMVAMTALAASILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFK8</accession>
    <name>A0A835GFK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFK8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="14005" checksum="D61AAAF758211F09" modified="2021-09-29" version="1">MMERLGAPQTHLGLKAMISEVDEDGDNRISFREFLLIYRKARAGELETDSGLDAFARLTEINVDQVGVNGAKTFFEAKIEELAKSNKFHNEIIQEQEEKRREAEEKAMRRQRFKEKAAIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG16</accession>
    <name>A0A835GG16_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_005926</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the chromatin remodeling Ino80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG16"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019219">
        <property type="term" value="P:regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000237">
        <property type="entry name" value="Actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000016">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="663" mass="75900" checksum="B799C193971E342A" modified="2021-09-29" version="1">MEDVLVLKDYKTVPDIVHEYSPTLKFGHIPLVIDNGSYQCRVGWSINDEPNLIFKNLIARPRKDRCKKDAEPPATPPIQIGNDIVNIEAVRFQLKTQFDKNVVTHFEAQEQVFDYIFSHLGIDNDGSVPHPIAMTEAFVTPNYSRQLMSELLFEGYGVPGVSYGVDSLFSMYKNDIGDTALIVNCGYHTIHIIPVIRGQVIVDHARRINLGGSEMIYYLHKLLQLKYPVHVNAITMSRVEEILQEHCSIALDYQEEIRKWANPDYYEANVKRVQLPYVQTASSSGLTAEQQKERKKEMARRLLEINARKREERLAEDEEQLNQLLAIKDMIEDGDTDEFNEAIKGFDIKSYEDLQRQITNIHMRIEKNKQRIVAAATAEENLETRPTGRLNPPTEPEAFQTWLNETRSKYRELVARREARRARRAAMVKRRTAAAAERMRVISRLAAAGDEFGNQDSDWDAYKSISREADSDSEADGERLMELEEALREYEPPPANSSQHHQLHLAIEPLRAPELMFQPSMMGNLEAGLAETMEYVFKHFSPEDQLLLANNVFLTGGSSQFPGLKERLERELLEMRPFQSTHKVVVAKNPSLDAWYGARDFAGSNEFENWCISKEDYYEMGGEYLKEHYASNKYYKSPAPIVDNSLAPSIDANVVKEEIVVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG48</accession>
    <name>A0A835GG48_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_014156</name>
        <name evidence="6" type="ORF">HW555_006896</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG48"/>
    <dbReference type="SMR" id="A0A835GG48"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000166">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9639292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13449" checksum="9BB47CB1ED733A38" modified="2021-09-29" version="1">MPPKKDTKASAKQPQKTQKKKEGSGGGKAKKKKWSKGKVRDKLNNQVLFDKPTYEKLYKEVPQYKLITPAVVSERLKVRGSLARRALIELREKGLIKQVVQHHGQVIYTRATKGDDPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGN4</accession>
    <name>A0A835GGN4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_018025</name>
        <name evidence="11" type="ORF">HW555_005309</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the parvin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9628050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGN4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21304">
        <property type="entry name" value="CH_PARVA_B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000015">
        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="89"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="258"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9628050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="368" mass="42015" checksum="812CA149F47623BE" modified="2021-09-29" version="1">MSSPRPKSPRTPVLPKKEDKEESFWDKIGTIGRKKRIKEVQDVQAEGKYAIDSPGSPTAPEIPPEEYSLHDNEERAIIEPRSLEDPRVKELIQVLIDWINDELATQRIIVKDISEDLYDGQVLQKLLEMLTKTKLDVPEVTQSEEGQRQKLAVVLRAVNRVLYGTAKPVPKWSVDSIHSKNVVSILHLLVALARHYRAPVRLPENVSVNVVVVKKDTPNQLSHRTFVETITTTYDDLGMKCERDAFDALFDHAPDKLQVVKKSLITFVNKHLSKVNLEVMDLDTQFHDGVYLCLLMGLLEGFFVPLYDFHLIPEDFDQKVHNVSFAFELMQDVGLAKPKARPEDIVNLDLKSTLRVLYNLFTKYKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGP0</accession>
    <name>A0A835GGP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01735">
        <property type="entry name" value="LSm12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="21531" checksum="7B79A89079DD79E1" modified="2021-09-29" version="1">MSTVVSDCFTIGSIVATRTCYNENIEGEVLAFDPQTKMLILKCPSSSGNPKRHDVNIVNLSLVSDVQIKKEVTTAPEPPQSLNLHRLNTRVRNSIENKRRLVSALSACLDPEGQRLFMAIARVIDDVSWAGQNIRVYNEVIITPPYKVDNVIGEKDSKPYNYIKKFVERHWRDHRDYRDHTAPNSSQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHB1</accession>
    <name>A0A835GHB1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="686" mass="78847" checksum="86F47730398C7170" modified="2021-09-29" version="1">MKRPVNYCSFAAVCVHDNRMVCAATEDGCNRKTFLDQCDMYEYNCDFGTRYRKYMGSPSNTCPGGQQDIDYQETYSIFCLGPELDIRNPLPLSYRPPTTCKTAIGRHSIKNVLNVASPINADMSLRRRADTPALPSSPCQHCLSTTWPRKTQELYSHYVASNVDTPTMDTIEANVARTTHNCATTPLLTPQILYTFSLNPEQYLDINANIIGETYYFKSTYAKVLKEATEDDDYLEHPEELVPSLEVMSDHIGSPKTTTELPTRYVESSEQRFKEYKQSNSLYYLPEHTPRNEQSVDKKYMTNSLPISYPPIIRKAAIGRHKIDNVQNVAPPIYAEMSVRRRLDTPALPSSPCHQCVSTTWPRKTTELDYHYLQNMPLRSLVTWTRLPWIPSKPTLPAPPITVPPPPLLTPQKLYTFSLNPEQYLDINANTKEATEDDDYLEHPEEHIPSLEVLTDHIGSPKPTTELPTRYIESSEQRFKENKQSKSLYNSPEHTAKNEQSVNKRNYRLLEQNFEYINSIKPENPMIIKANSYSTQLQQLQFKISPQIKTYYLRDLPATSHHLLKRQEHPQHIHFNRYNYLGHYPDSKCNSGQSSTCQCITCNMKTTALKQTIKTIPNYKSSLVNLNIPTPRPNDDINLNTVEFDLCCDRPKTWQTLPSRIITMMPNILETKSTLKRDKPCKLDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHG8</accession>
    <name>A0A835GHG8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000084">
        <property type="protein sequence ID" value="KAF9416756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHG8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="350" mass="39464" checksum="94C0DF889E23EE45" modified="2021-09-29" version="1">MWTFDDASRLGGSDMDSRRACPSYEAGLDVCDPLGSVLDWSSREPARILRRRCRSEGIDRSPYEDVSREVNRSADGNCRYHRALPNKSHFTLNNSEPQYAAARFRHECSLPTAENGDYVMAHEHDRFYGYQPGRSKLYRKSPTRPLLVTTLSNTKVDDRLPKVEELLEKVDQEMMEVQATKQPLKSILNNPLPNSPLHGILKKPKNRPQPDSKSMMEGRRRQRAASESDNLFCSYNSIGSPMAGYDNRLSYLSTNTKRAKDNSGIGYSYGSAVASLGSGATPKSPTRSHSSGTKQFRGRKDQMVIKEDHDMHLLRTTAINETVRVEPVMDMVRKVPTHETWVVVALAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ17</accession>
    <name>A0A835GJ17_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_010079</name>
        <name evidence="11" type="ORF">HW555_006012</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000008">
        <property type="protein sequence ID" value="KAH9645880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ17"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9416699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9645880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17095" checksum="57DABDC84A8661AD" modified="2021-09-29" version="1">MAEQRERTFIMIKPDGVQRGLVGTIIERFEKKGFKLVGLKFVWPSEELLQKHYSDLASRPFFPGLVKYMSSGPVVPMVWEGLNAVKTGRQMLGATNPADSQPGTIRGDLCIQVGRNIIHGSDSVESANKEIALWFGEKEVVGWTPAAENWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ84</accession>
    <name>A0A835GJ84_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA/RNA non-specific endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ84"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000007">
        <property type="entry name" value="Alkaline nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF17">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032846043" description="DNA/RNA non-specific endonuclease domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="7">
        <location>
            <begin position="105"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42628" checksum="B625AABD8D7C29EA" modified="2021-09-29" version="1">MKWGGRILVPILLIFLLSFTECILSLNKDFNSIGPVFIRNGRFLEPNTKKGDIAFNRSETVLVSCPKRKIVLANQTTSYDTLSGPKDPQFQGHSLVGYQVRSTFHPIYEACFDKNLVRTHFVQHRLTPNSVFRQNGLKRPQFTEGNLFGKTRMNEIYKMNNQVKALDAILGPNMGNNYLSKNQVGKRFLSRGHLAANADFATSALIRATFHYVNTAPQWMRGNAGDWAALEEGLRRRVHELGTPVMVFTGTHGIMTLPDKEGRMKEIFLHADLNNNFDVSVPMYFYKLVYEPTQKRASVFITINSSFYNDTVTDSLVFCNNTCDKDDYYNNFNWLRWRSNDGTFSFCCDYEQFVRKVNYLPKLDVRGRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJD5</accession>
    <name>A0A835GJD5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJD5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="192"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="363" mass="41760" checksum="C67636BE62D291E7" modified="2021-09-29" version="1">MVIVTRSAYKRACESWDSSDVSQKNIIPPWCSSGKVYERSKSKKLATPKWEMRSTYPLRTNIWEYLYEDNVEQKFSCSNKRRHRKCKQKSVESDSCRKTAVWMILILGAVGIFVSLWKSNTTREDLTPKARITSLPQMYSSSSVSFECCNRMKYLSEQLARTEQTLRNALRSRTLMLASRTKTEQMATVAEAQDIDTRYIEGATASKGSDTTEWGGRVALWGVVPLWRAAPPPDTVLALRRPTLSDCWPFIGSYGEIIIQLPRTQRVRYVTVEHIHPDTARSAPKHFLIYGILANNTWLKIANSQYRAEGPAKQYFSLAYKYLEWKSLAFRVLTNQGNNKYTCIYRVHLYGNIDKSIAPFNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKP7</accession>
    <name>A0A835GKP7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKP7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24406" checksum="15A964C085FD3828" modified="2021-09-29" version="1">MKTYFTTNECGAIDDVMHDVHVVNTDMKCATIHERNATYDSDSSNRSIDVIDRDVKDNNNIALFTSRSRQKPLKTVKICGKTAEALVDSGSDINLITDEWRRQLGLSVNSDSVSVSGLGLSIIKTSGSCTMDIIIDDKKYENVKFYVISKSEMPFCIILGNDFLQRVTMCMSGIVSEGRHSVRMTECGINLIDYRGFPVDVPSRNAVGVAPRYFKYAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKW8</accession>
    <name>A0A835GKW8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_005595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKW8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="230"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9417281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="535" mass="59787" checksum="7F67C3314FAD789D" modified="2021-09-29" version="1">MVVSEEQPPAVEGDAAASKKAAKKAAKAAEKQQKKAEHKAASGQVQPEASEPDVSEGRYGQLKMIQSSGENRDRVYTDVKDLSVKLNGQNVWVRARLQTSRAKGKQCFAVLRQSSSTVQLLISVNEERAVSKQMVKFTGNITKESIIDVYATVVKTSAPIESCTVREVELVGTQLWLVSPARAQLPLQIEDAARPEKSDDPEALKIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCKLFRDLLTERGFVEIHTPKIISAASEGGANVFTVSYFKSSAYLAQSPQLYKQMAIAADFDKVFTVGAVFRAEDSNTHRHLTEFVGLDLEMSFKHHYHEVLYTIAGTLTDMFRGLRDQFAAEIATVGQQYRVEPFKFLDPPLRLEFPQAIQMLKEAGVTVGEEDDLSTPDEKLLGRLVRAKYDTDFYILDKYPLAVRPFYTMPDPNNPKVSNSYDMFMRGEEILSGAQRIHDPEFLTERAKHHGIDISKIAAYIESFRLGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKY1</accession>
    <name>A0A835GKY1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKY1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="353" mass="39263" checksum="FDA250890D9E2C55" modified="2021-09-29" version="1">MRKSLNSKQRQLRKSGNELLPNDAAELQRVSTEQQALQKHLEAARKQARQHSMLIQEYETKQRQQNPQLAQQSVINQQQITSNQTVFAQNQNIGQGQQVQQQGTINRPMQLGLQGATIQQQQTLIRTQQTVIGADGQPISQQRIGLVTSPLNAQGRLVTQGGRTLVIEQAGGPQPQLVRQLGGAGVQERGQAGPAMGQFAGRPAAAGARQPGARPAMSPLHVQSPLAPQSPLHQLTSPMQSPLHSQQSPLHHTSQSPLHPSTQSPLHTQHRQCTRNKLRCRSTPRCPSSRRCTRSNLQCICNSRRCTRNSLPCTRRCRLNTFCNNCKLRGPAPNYRRPAGVLRYINNRRFRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLH2</accession>
    <name>A0A835GLH2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
        <property type="term" value="F:L-DOPA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035643">
        <property type="term" value="F:L-DOPA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00965">
        <property type="entry name" value="OCULARALBNSM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="355" mass="40682" checksum="5C1E631006B5F154" modified="2021-09-29" version="1">MSDPTIQTFCCHHTGNKEDFAVRIMDEFNTDSYNIVCLVSSSVGILGSVYQIFPDIINRIKRGVGSTRGRRIIIWLAVADLLASFGVLLRSALWLRYKNIMPLPDDDVSVLFCSIVSAWTQYFYTVTWFWTLFYAIDTWLTIKGRDSHTLLYHSIAWGVPAATTGVGLSILYIPNAKCHNLPSVTSALYKILPNYCATYLPIAMVMIVNPIMYVLSSKDVEMAVAVPLAQFTSKERRVVDTLRLKFFLINVVFYLCWLPNLINGLLLWTMWFNIPVKVIITIWYIMALTNPMQALLNALVYRKWNTNKWRQMPSFSNESRKEFRFYDEQSPLLGSEPPRLQLSPIPPGINNYATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLK9</accession>
    <name>A0A835GLK9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLK9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF15">
        <property type="entry name" value="RE18252P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="114"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="307" mass="36464" checksum="2EA129D556E8DCD3" modified="2021-09-29" version="1">MADCTICQPRASRKFISELFNEQLYEPVTKRNLTHVHSRTHTDRTRHCNRTMTAASCERDGCHRDVYWLLQRAKRRHITGPRVRLERRGRRHFEASVAFVRTRNDACLVATVLDEWTEEKMRPILWDQKDPFYFKKNMKPKAWQEISDKINISPDKCKHKMIILMSSFRREKAKIMHSMADSSDTSQAYKSTWFAFKDMAFLMDKDNERKRQSQNCTDEDDDEDWAISNFQNKLLRNHVGIPIPMRNRKSLAYKQDVYQKVLDLVQDDDHPTHPTPGPSQTIEERDDEIKSFLSFIGNKMKRYTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM6</accession>
    <name>A0A835GLM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-AMP-activated protein kinase subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_005978</name>
        <name evidence="10" type="ORF">HW555_004580</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000772">
        <property type="protein sequence ID" value="KAH9631207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000139">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="9">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9631207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="281" mass="31545" checksum="7962FE837CDE04BE" modified="2021-09-29" version="1">MGNAGSNQPKEWHRDAVTKAPDVGPSSPVKEGEAFTFDKKIDDDRIGRDEENNIEDGAPYYTKAVPESDVEYSGPRERSNTLTESSKIIDDVKVLPTVFKWEGGGKQVYISGTFTDWKTIPMVKSHGDFVTIIDLPEGEHQYKYFVDGEWRHDPTVKVVDNGMGSKNNLVTVKMSDFEVFQALAKDSEGIHSSAQTEYSQEIPQSKPWEKVSGPPILPPHLLQVILNKDTPLSCEPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLR5</accession>
    <name>A0A835GLR5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLR5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="136"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="337" mass="37550" checksum="A067FB36488D64EF" modified="2021-09-29" version="1">MTLRWGIVTAGKISNDFVNAFNSYPEKGDQKIVAVAARNKDRAEAFAKLHSIEKVFDSYQALANSSDIDVVYIGALNTDHYGLCKMFLENGKHVLCEKPFCLNAKQTQSVINLARKKNLFIMEAVWTRFSPAYIDIEKQIEAGALGEIRFIEANFGIFCESDRVLKKEYGGSAVLDIGIYLLQLSQYVFKEEPKNVTAIGTLNDSGVDESETIILDYGNGRRSVLNTQSGLVLKNTATIYGTKGRITIEDPFHFPDKVTHVDGSLKTYPLHKSKLPYVYGNSAGLVYQALEVARCIRAGLIESPRMSHKESLVLAKLMDTVRGQLGVHYDADDEEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM02</accession>
    <name>A0A835GM02_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuole membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM02"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39347" checksum="E07FB23CAD3A0DCE" modified="2021-09-29" version="1">MDSDSLVLWRRPLTTLEYFFKELFILISTGLQRLLAYRLLALTIFVAILGTVVSYYVSGPHQPYVQVVIATLAWWGWWVVLGVCSSVGLGTGLHTFLLYLGPHIARVTLAAYECGALNFPEPPYPNDIICPAQIDPKNTVSIWNIMSKVRIESMMWGIGTALGELPPYFMARAARLSGGGVAELAANDDSRTGRAKIMVQKLVQKVGFAGILACASVPNPLFDLAGLTCGHFLVPFWTFFGATVLGKAVIKMHIQKMFVIIAFNETLVGQVLSWVERIPYIGPKLEAPLLEFLRNQKARLHKNDSAAPIENQGSVLSSLLEKFVLAMVVYFVVSIVNALAQNYSKRVGKKKGKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM67</accession>
    <name>A0A835GM67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_002378</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51308"/>
            <dbReference type="Rhea" id="RHEA-COMP:12953"/>
            <dbReference type="Rhea" id="RHEA-COMP:12956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.225"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mical family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.225" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120501">
        <property type="term" value="F:F-actin monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000004">
        <property type="entry name" value="protein-methionine sulfoxide oxidase MICAL2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057494">
        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF54">
        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25413">
        <property type="entry name" value="Rossman_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0440">LIM domain</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2439"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2463"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2528"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="19">
        <location>
            <begin position="1281"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="839"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="923"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="997"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1136"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1246"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1394"/>
            <end position="1556"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1607"/>
            <end position="1635"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1660"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1790"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1870"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1979"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2058"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2102"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="883"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1136"/>
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        <location>
            <begin position="1250"/>
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        <location>
            <begin position="1400"/>
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            <begin position="1504"/>
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            <begin position="1608"/>
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            <begin position="2104"/>
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            <begin position="2118"/>
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            <dbReference type="ARBA" id="ARBA00001974"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049522"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9421697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2558" mass="286872" checksum="8F26A16A9675BCDA" modified="2021-09-29" version="1">MENINCIHLIHTAIKSVFDTIGLRCAQLLNTYGFFKITKVFCIRTILKRMYTIRGFSVDQLRVIQRENCLFATQSVIMPATLRGGPRPQITSPCLAVGEARRPSYCAVTIGSNVDLGYPPRVAEREQTLFDLEFYPKSNYWAKLASSWKAQALFKKFDARANHKVYAKGRACVSGKVLIIGAGPCGLRAAIECQLLGAKVVVIEKRDRMSRNNVLHLWPFVIQDLRALGAKKFFGKFCAGSIDHISIRQLQCILMKVALLLGVELHEGVSFEELLEPRVAENSETLGWRARVLPSDHVVSQYEFDVLLGADGKRNTLHGFKRKEFRGKLAMAITANFINRHTEQEASVPEISGVAFIFNQKFFKELYEVTGIDLENIVYYKDDTHYFVMTAKKHSLLDKGVLLNDYNEVSRLLSVENVDRAALMRYAQEAARFSTDGRLPLRDFALNHYGEPDVALFDFTSMYAAENASMVYERHGRRLLCQLVGDSLLEPFWPTGSGCARGFLSALDAAWAVRAWGQTPAPHPLEVIAERESIYRLLAQTTPENLHRDFGAYTLDPGTRYPNLNRAAVTPHRVTSFYDSDEPLPLDAAPTARKRRREAEVSEEALVSWVAWSEPGIRAASSPAALTELLRRYRPDLLPSTTVPRAVYHILQQEFGIAPFSSGGSLRDVPDAKLRSYLTRVYNAFKGEVPHVHHETDVFDQIKQSMQKEKHVRNIEHPVSVYTNAADADKSHSSYRKKRRSVRPQQEQILALLDPEESPDPKVLRQSLAQLLQGSTKTRVQEPTQLAHFFQEEVAKPVKPSRRLKGLDINSMRIPDYSMFDDSPDTDATVVKVEAKKTFSRSLSTESAKKPQYPSSSSIDGAGKFTRSSESPLPQKGRRLSDVVNTSRIRHSQSPEVKVPYKRSNSIGASEIANTKRIAQLFEGHKRRHTPSPESRSIRSGSTTNPEMALRLQRMTEIIEGKRRDTPSPDRRDKKECIGNPEMAVRRQRVVDLIKQGQGLGQEHKQRQPPDIPQRRNSDEMAFRMQRASDMMQKRSAESKRPKTGRRKAAREITKQRFEKSLQMLAAERRLDFAPSADLENDYGLQQYRASAPDFDERVKKLEKKLQHYEEGRIVGGGGRTAGGGARVARLAAELSGTSTNTTTPRPSSKPKDLMRSVGKIERDDWNMKEIERKIMENRLGRPEPKTAERVPKWDREQFLGRQRKLKEGEGNEEKWVEIDETLHKLDQKLKRPDQGTKKVANLATKFVKKQPEAEMSKTPPKETSKEDSKKSWRGPAFTGMQCAACGTRVFAAEGVTADGLHLHRACFRCAVCKTVLRPGNYTMERYGSRLVCLRHSGVSVPDAVAAVTALANARSHPPPPTPERISLELSDSGAREIDEDEWTDRNFLASETSCAGGLSDEEESSSDEYTDAGDSDNGVAASPEPQVAAPRPAHSELYFSDDSFGYDDYSDDGAESSGNESCSRMRAAREARRREVPADARPPTDSSEVESEEESESSDEEVSSATEVSTDSEFAREEVAPAPSPPAILVTEATPPAPPPPQEYPLSRTRSAGGLATKRALELKRRYLLGEPSPPAVRKSDSTSQIDTKFEAFRSTITEFQKMLHPAPAPTQQPQPQKPVVTFQLSTEDKKSQPMPDIIKNLVADAPVDLLTKVDAPLIKDWRSESTKDEKDPDLDSDSLSEDDSSHTETAPNQSVPRLEVHDEGGELIQLDSLMLINNSTEDEKASGTATATGTTIVAAAESESSESGRDATTLALTETELSDWAAESAVLDDCGFDDKEERKRKHFEFADEGDQDPSLETPVTPKNEGYMELVDNDYDAYSPGNDRSMNFIERSFSETVFKPASQENSYRQNLCPIDLDDIEDIDADTEPLDLKSPQLLKSVENDVSEKSNSDSLPKSESIHKSDSLHKSDSLQKTDSLLKTDSLLKTDSLLKTDTMSMQRSDSIFKSESVQVDNSSEPKIENKIETLSLSEISPPLEKDKVVDTEPSEVSPPLVPDTPKVKLPMSIPFSGPCTIRLYSPAICRSASETFNRSTSRSTDSPTRSFELSVSINLSSGSLSPVSPVPARDTTDKVQQIKREQEEQTEVVRRLVLERLGSVPKASRKSVKRSRASPAAVPPPVPPPPILPAPPTPPPPRPAPPLMPLPVTSSFSDPELARERRSKSIMKSISNYLNRRLGPRHKEPQILSNAHKSTGALQEAPPVPPPPASYCPPVEHRPTHRVAAWHYKTSLEANHVTSFHGHRNPLTAGPSSSAVDVDERDAMQLWFEARWARLVAQRRAREEPRDEPTARRLARLERRLTRPLSGKLLIEGVFNISAEQQAATVAELVQVSAQRDAHQALMAADSNETSNFNLHYRRQVLFKINVSTIVLPQFIIFIVTDIFIRSLNHGIKVTTLLSTIFKNKKYAITIFATDWSVEERYKLFTNNYLLYNVQLKIECTTAMAFHSLCIIYIFLPTSKLVFLNVFLFYLYLANFMMFPISLMDYQLYDFMSILLHTKQFYIQELTMKLHVIVVRSCFQITNAKHIIILIKMQCFLLFSIINLAFYNNYVQRYHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMD9</accession>
    <name>A0A835GMD9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMD9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="270" mass="31022" checksum="2017E49FB126061B" modified="2021-09-29" version="1">MPRKRTQLSRQTATAKRLRVLRSNETEDENMHRLAAQRAITEQNRARESSVDRSQRLASQNFRTLANRQRESSAERSQRLATQNARTMANRDRESSAERSQRLATQNARTMANRDRESSAERSQRLATQNSRTMANRDRESSAERSQRLASQNARTLANRDRESSAERSQRLASQNSRTLANRDRESSAERSQRLAQQNARSTRNRTRRQHNLLNAAFTYDCTVDYSELNDIDIGRMDKICNLCQAKKWAAETPGLCCSGGKIRYPCAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GML5</accession>
    <name>A0A835GML5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_004009</name>
        <name evidence="9" type="ORF">HW555_004729</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GML5"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9630718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="19351" checksum="4336E7D736EBF1B8" modified="2021-09-29" version="1">MAGDESDSDLKPSSVAIIREVYDSENAHIKFEMELERALEAGVSVIVIEPEPLGEETARWIYVGNLLHKVSVYSGLCSIASGLAWSSLACAPFGIVSVLCAGCYTLSWQWDPCCKYQEEKNRRHLSTLPMLSDLTSASPVVLVHTDNRRKIILHTTVSMTATAICLWRLYNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMX3</accession>
    <name>A0A835GMX3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_003845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000040">
        <property type="protein sequence ID" value="KAF9419726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMX3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="35469" checksum="47A7C882FA6F7C14" modified="2021-09-29" version="1">MSLYASFIAYQNYTADPVSFCFFSGYWNPHTFNYTKMSVKKVAVVTGANKGLGYCIVKKLCDKYNGKVYLTSRDEQRGRKACDELKKMGLDPFFHQLDVTNKESVNNFVKHIRQENEEVEILINNAAILFLKDAPEPKNFQAEQTISINFTALVDFTEAILPFMKNGGKIVNITSSSGHLCRIPSEELRNKFQSENLTVEELKTLVNSYVEDVQQDKEIVKGWGDSPYVVSKVAVNAYTFILHRRLTPKGITVNCVHPGYVMSDMTRGGGSITPDDAANVPVQLALTPCGAGLYVWHSGKAVPWDGPDPRVYIDGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN01</accession>
    <name>A0A835GN01_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9419999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN01"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="37193" checksum="013C9E98B1B2CB1F" modified="2021-09-29" version="1">MCDHTLYKSGSNRRFQFKFNVNKTKNFPTTETMTMTDRQDTEHEISIPIAPIRTKTNVRGLVTERYLDYAITLQSRGGWRAYCSAKRITSGLPLLHSTAEDIWLNKPFRGLKSRFGVFYSVRLQPLLDSKYSSQAITNCGRLKGRENYDDWCFAAENVLVLEGMADNIKQPLPSTATEAQIADDLKAKAKLILTIDASLYIEENRKPEISPEGVPESDSDEENQHDETYVPEDSSSESEDTFVDTMTLSPEAKNIISENGDTNLPEKREENSCPLTAGNGHLGKPQQRLGRLIVRVRNELTQKKKEEEKKIFTNFLMSPHKPRLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN27</accession>
    <name>A0A835GN27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein 12-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55200" checksum="190DD068BE7661D2" modified="2021-09-29" version="1">MSVKYGATDVDRKTEETDKEATTEVEINLSGPFKRKWWRVSQHVLFGLGHVYNDLCAAMWFSYMMLFFQAVLEMRSAVAGAMLLLGQVIDALATPVVGVLADKFGSLKSWHLTGCALVTCTFPLLFVRCWGCWLTEDPDYLDWWMPVYYGVLIVVFQIGWAIVQISHLAMIPAISDNLQVRADLTSIRYMASVTSSLAVYLITWVVLRASNYSTFIGPMDDYKFRGVSLIISGIGIVSFLLFQIFFKLKPKKEEKANGHAVTNGHNGTSASVQNEESGTLEVAKSKIMYFLRMPLLYQTSLLYVFSRLYWALSLVYVPLFLEERLVFNPSAGSELVASVPLVLYISSFFFSLLLKSKINRFGNQVAYLVGSLLSLLSCLWIAIAIDPHASIVQIYMVATLIGAGSSITLVSSLCVTADLIGPHSHQGAAIYSIVTFADKLVTGIAVVAIENFKCDNELNCPQYYRAVLTYACGGSAVLGMLSLSFVKFMPGHKTEQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNA0</accession>
    <name>A0A835GNA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="155" mass="17442" checksum="4D49BC713839EE31" modified="2021-09-29" version="1">MTKNMRQAGDNTFVDILNNIRVGELTMDQLEILDSRRIPLEGPFADGEAVRIFPTTKQVDANNSAMTKKLGKSGILGTLTIGIGSRVMLRRNINVNHGLVNGAMGIIRRIEWPSLRREQLEPDVHQRRSEGRAGPLKEQTRNESHNSSMHQFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNC2</accession>
    <name>A0A835GNC2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNC2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="15213" checksum="FA10CC7130D47DC4" modified="2021-09-29" version="1">MSQSESNYTYHSTAIKKTGPKVKVEDYEITFNRLMGLTAAYVFENRWKFPNIRSSQPEATGFGMGTKSSRQMQALLICLIKMGNIKNAEGITMAKVMKSSMISVKIVWMMFPGAAIHDLQTLMVDTPEFKGLFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNF6</accession>
    <name>A0A835GNF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">WD repeat and HMG-box DNA-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="9"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="398"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="700"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="911"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="105084" checksum="14E0B5DCB521C6A4" modified="2021-09-29" version="1">MKIDSKPLRYAHAEGHTDVCYSEDGQHIITCGNDGDVRIWVDIEDDDPNSHCVGESALAVCYKDKRLYVATDNHVVQAYTYPAFDKDGIVTRFTAPVTQIKSSSKIEVLFFDPIVLGCTSENMEAKLCNLEGGAPLFVMTEHTGPVLSIAICPHMKFASTACGDGKLRIWDIDTQKIVKEVSCVPKINTFYAAKVLCRMDFEPTEGKYLAYPNNREIILLDCETWGQRMTFTHNLAIMFKIKCAISQCVFSPCGQYLAGSTVAGQVAVWEIGSGACIDITTHPTSHNVTAMAWNPKGNGVLAYVDAMGQLGMLVNCYGKDSSAATADNNEDVEMIERVDDNDDIVDDLIENYESDDDNAISLQKIKNETLGLVEQDESRPASRRNATPAPSTVPPQAPFQPSSTPAHLEHRYMCWNDIGIVRCHTAENGESTIDVEFHDTNLHHGIHLNNYLNHTMASLSSTVVALACETPSKLVCISLVGSSKEWSASMPDTEEILCVAAASHVVAVATNARLLRLFTPMGTQRQVISLAGPVVCLGAFNTAVLAVYHSTDPGPSDQHLAMDIVALNGRQVRSKTVPVPLTPASKLAWLGTSDVGSPCAYDNTGMLRMYDVSSGVWMPLCDTNMHARGASDSWFIVSVSEATQKVRAILCRGASFPATAPKPIIAELTIQIPLCEMDTEKSQYEEQLVRWAHTTSDVDVKTARETALKLFALACRSEIEQRALELMELLKDDRLLPLAAKYASRLGRVHLADKLGNLAETWEKEADRLNVAQTSHFQELDTQETYDVTNTEQDLNASLIIPQKVKEKKVDADTSLRPVPIKSSPGRARNIFKKKSTNSSVAQSPLSLTERTLVEVHKPTENSENDDPSAPLEGETFVDWFTRNKSILERQNPELGPSELTRQGIKIFKTVQGKGANNTENGPKRKLDEDTNNTETHVVNAPKQSKLSAFAFQKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNQ9</accession>
    <name>A0A835GNQ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46183" checksum="7EE6EC5941C083C8" modified="2021-09-29" version="1">MPKVTVGKKYSKAYTEEDVDKALQAIKNGMGKKTAVNKFNIPRATLQFRLSNLFVKTRPGPDTVLTDAEEKEVVKWIISGLAKVYLDENPRPNNFIDNTPGDGWYKLFLKRHPELSIRTSEAVTSASSKLSEKQIRNWFKQVEEYLKENDLFNILSDPSRVYNGDETNFILCPKNTKVIALRGTKNVYEVDHAQSKSCVTVMFTFSADGETTPPMIIYPLKRMRPEIQKSVPSEWGIGLSDNGWMKAELFIQYIQNVLHPALMKRNITFPVILFLDGHKSHTTLQLTQLCQNLGIILIALYPNATRILQPADVAAFRPIKVMWRKAVLEWRTDNLTKSLLKTDVAPILEKLLPKLNKTTLKNGFKACGLCPFNPDQVDYTKCLMPSKPVQEMLDDNCSTSLNYQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPK0</accession>
    <name>A0A835GPK0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPK0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21484" checksum="86864C3BF7367D51" modified="2021-09-29" version="1">MFLKKVSEPRPPHESVSKKARTETEIKKKDNKEVNDSMVKFLDSRINPEKENHHLSFFKGIIPILNTLTIEETLEFQASVVTMLQKIKSRNYERPNYGHWRDSFNQITGPDQYSGYYTHNSVNQQPIPTQDQHYPGYSMQYNTSNQQATTSIPSTSSPTSNPIPASPSASSNRSIHSQDSDYLDFKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ21</accession>
    <name>A0A835GQ21_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Immunoglobulin-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IGBP1/TAP42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ21"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.540:FF:000003">
        <property type="entry name" value="Immunoglobulin (CD79A)-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38979" checksum="50D3CBA852B0515C" modified="2021-09-29" version="1">MSKEECAKMSLDEEPLTKLFDDAMKIYEAIEKSNEPTNSNSTQLSVKSAISKFEKATNLVSLAQMFSRNEGVEELPTETLRYMLLPALLGTLTLKLCNQPRIDLVNVAEIYYKDFLQRCKDYGVTELEVPSTSESREVEKPHSEQAKIASLVLTREAKIRRYKQAQELKDQLAVLSKAMESSADEETKRAYFLKLLENYINQAFEELSSIEQEKSILEYMAKNAGEPKPAERPRAPLKPVIITRDELQKAVFGAGYPAIPSLTVEEFYDQRVREGLFPGACSSIPHTTIQSTENDPDEEETIRKERLEEQDDPEERARKNNMDEYKDDHRRGWGNRHNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ91</accession>
    <name>A0A835GQ91_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ91"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPR158/179 extracellular" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="37851" checksum="F4FF7DB861E04153" modified="2021-09-29" version="1">MKGTSGIDIDLRRVDIDQCPIKPGSTQLNIFAGTDKCKKKTTELYFFKTIEFFWKPNETFYDPFDSRSSKAIRIKNVPLLASRTKDIKHITMSQLAEVLSAQKTLEESFIKKMNALEAQIQTAGPAKDTVAKVAEEFRAFRELVFGMLGLLRRQISECAQQIDEIETRSRRKALIVQGVAEAASEDCIKVTLDVLNSKLGLGLTASSLKVCHRLGQANTNHHRPILVKFASVEAKMKLWRAKTGLRGSKLALKEFLTKTRQSVFGKARQHFGMRSCWTLDGVIFIKAPDGSRHKVMSLDELGLLLGRYPRAQDTSTSADKRATEVLGGLKGTRKLDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQJ3</accession>
    <name>A0A835GQJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-beta-hydroxybutyrate dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQJ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30406" checksum="6EDD846D744129AD" modified="2021-09-29" version="1">MVAGDVTRRASITAPSMHRRPSARRGSLIKGSQSTSQEVPWDIIDRCALPIVLCHALAVVLSTVLNALHLSSVSVFTLFLWFSISVTGSLWFYHNLQVTAAGKAVLVTGCDNVLGNALARRLDDLGYHVFAGFQSKAGNIDADMLKEDCSGRLHTLQLDITSETQILSASLYIVDHLPEGAQGLWAVVNCESWCALGELEWVPFSVIKRAMDVNLLGPARLVQVMLPLVRRARGRVVLASSILTHVAAPVRGVHAASLAALDALAACLRRELKPRGVDCVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR08</accession>
    <name>A0A835GR08_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR08"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="15866" checksum="5814CCFDE6120D90" modified="2021-09-29" version="1">MWLNQLPAQIRAVLSVNTESSLEMLAAMADKMMEHFEPASINAVSTATTCQENLQIAFLSKQIEKLSLEITELRTNQQNHRHFPRFSHRNRSRSHSRSRQHSNIKPGNPNWVCRYHYRFGDQARKCESPCSKKREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR15</accession>
    <name>A0A835GR15_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR15"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="16057" checksum="E8836D9DDCC6C41A" modified="2021-09-29" version="1">MSHFSKHGCFVWIIRNPTDYGDQLIMTTVTVALTKRIIFKAIPKKIQNKAVPAALYEFYCYNRTTFGHRYVLLTVMLRGLVTRHLLPFSHSRKLLAVSSRLYNKVLRILANIKPSQTRSDGVENLKPLRCMSSNPNTSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR89</accession>
    <name>A0A835GR89_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032946275" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="242"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="636"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1655"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2089" mass="234134" checksum="9D10EB15EDD91D0F" modified="2021-09-29" version="1">MYRRWRWLAGTMSAPLNWHKWLVLSLLGLALSARTIGCDYSSITEKFGAEAVARCNEKCPFQNRTGNDHFDVSCGSDCSLQQCKLGCSLWQEGLENSCQIVCNVTSETVFSRELYCVMGCNEALNTYFQKLRELIGIPTAPALVADSLTATSLSLVWEAPNLGNLSYMVQWRYEELPGTWQYYSNSSHSDQSIIHVDGLRPYTKYRFRVAIFLSGRGGTGEPVYSAPSVVISTLESGKPSSAPTSLRAAAPDPSRVAISWEPGPFPNGPLISYVLRLADTQPNTNDALEDMPASNKTLFYMFQNLAPAREYEVSVAMRNAVGEGPRAHVKISTPPLPTSVPSQQPILILGGEQNVLAAPANDMLSDPVELYSTEYSIAGVGLDISSDSLFTSVSNGVVYRSSLSKKSLSEPILTPNNYKPQDLSVDWLNRHLYVLGEVHHRAAYGSNSTFTANWEILRCNFDGKNIITAISGFNSRPIHFEVDAYNGYLFWAQQGGDRGGLYRLDLANISNGVHPDAGPEIIVRDAHLGAFTVDHADFRILVAHLRKNTVLAVSLDGREVTDFRANTQTPMFLSTRSIAYAGGLFYWTNGKEMLTEEYHAQSDSYFHNEYPLAYNTKTIATRQVLVALRSCQPIPVPVNPPLGLQSVMGINRAKVSWSPPHLLGHQGSGAWQQWTFHLQLTHVDTGDVIDIMNITESTCVVENLKQDAEYVIRVAAVTESGSGPWSSEFVGKTLASSPNTLHSTLLWSGPDGLLQTDLTGDNLQILIHRGLLKNLHITDISWYRDLLYLVTNASTVMWYNTTTHKRGLMSNMDNVGSLAVDWVGKKIYWSNPKQQLITRGNLDGGNREPVPIVTVAKELTIDSLGAYIYWNTGHAVEAARLNGENKMIYYPAQLFSGKQVMGLTADLEEKWLYWLVSGSLVTRLSGTATLGPLCYFSGRLVWVQDASRAVVSDLAGRYTADLVPRVHVIAVRDPTLHANSESLIAIPETINPSSITVAGEWDRFNVTWDPATRVNVNNSKVYYDVSLHFPGQYKIEKTVEESWLEVVSVSVAPGGPQSAIFRWGSPARANGVIRGYEAQCWVVGADSSSPTKPSACADAHLSPSHTQLMLRNLTPASKYFFQVRAHTDAGYGQYSEVVSASSDDVNPIPKVMVSSQESIKIIDLDSGESETIPKSTGIPVDFAVSTEENIVYWVNNLEEIFSARINGSGHFKLTSINGSASSMCVDWVSRSVYWTQLEITSVESYVTYRADLGMPNTRPHITRVFARKQPIYSLQIAPLHRTLFWYEEIGHPGLGTIMTSHLNGSDIKPFFRNSETSGRECNCPENPQVAKAFVIDMTRSKNYDLYWVDPWLHHIIATDMEACKCRVVVDATEKKKYGFTPMSITVDSRYVYWFNSTQKEIFYTTKHHKTRIEERKTAYGYKIMALDSGNQPYPPRLCLFPKILMLRPKLISNSANSITLHMPYVEKPNRCHSLEYEMSTTEYTIFYRIQLRNDTSLCDKESCSFVTTTNTKVVINDLKPFTNYTVMLEATNYYAKLHEVKPLVGTPMIIQTAAEAPTAPKDVTGMVLSPVLAYVEWKPDPGLSYEVHWRTDDSSSLAHKLIKEHNTFEVSSDRAANITRLSPGTAYVVWVRARSRHSAVWADSAPLRLRTFPPPAALALRATTPTHIRLLWPPPTTYQLHQFRVEYMEASPTSSTWKPCTRDERNEWVATDLRPLTRYRFRLRLQYVASAPPYYWPHDDRFTFGTLGDVPGAPGPLRVESFRNGVLQVKWNEPDSRGSPILSYRVWGRPQHRISQGNENITKNLSELLPANLPSDIDDKMKMRVVREGWELLHNCTAYNARARKKAAVANQIPTNPARRGPDVELATLRQLPTRHSTNILYNQKCWNYAAEARPSFRQCLQLVTALRDKTSPNITLTATPSPAPHYLTLLPDDAVDNRTYLLDENDNACLDEDFPDHMEPSRLLPERTPKYLELMYDSDSAQGTICDGYEIPRAPITYMPPFSRHSIVGVAPNRLIKPPLYRTHSLRTQSRPPNATIIPLRNGLVKRASLCEEIRARDPRPTSSREQPRVDLDFDKHTIHKIKIELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRJ3</accession>
    <name>A0A835GRJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 10"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRJ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF91">
        <property type="entry name" value="ALKALINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="463" mass="51161" checksum="D403312F882C5175" modified="2021-09-29" version="1">MGDSETPVFDEKNKDHWNMQAQWILQSKLSNSLNTKVAKNVILFLGDGMSITTLAATRVYLGQKYGHLGEELKLSFEAFPYTGLSKTYCVDNNVADSACSGTAYLSGVKANSGTVGLSAAVKRGDCIVTTTRVTHATPAASYAHSADRRWEADTDMPKKGLRCEDIATQMVKGRVGSKIDVILGGGRRNFFPRGQTDHEGYYGYRSDGVDLIREWKKQKEAQGVFPRFVYNKQGLLNLDDSLYHSVLGLFSPDHMPYHLEAGDDDPTLTEMTQKAIQMLKKKKNGFFLFVEGGRIDTAHHETKARKALDETAEFAKAVEAALRLVDLQETLIVVTSDHSHTMTYSGYSKRGTDILGLVNKNNASDNLPYTTLNYANGPGYKEPGRFQRYDVGKDNFSDVNYTYPALVPISRETHGGEDVAVFARGPWAHLFTGSFEQNFLPHAIAYASCMGPGLTICKSKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS39</accession>
    <name>A0A835GS39_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS39"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="613"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="727" mass="82604" checksum="FB157EBCE503641F" modified="2021-09-29" version="1">MVLPVPLIVQYPVEHIESLETQEPENVDLNIPAKRYRPAYVASEAKRHDGYEHYPSSTSRQEERGDINNDCDSSSTMREEPLPKKQKQQRDFNENWLTNTTFKNWISKREQECGTITAYCKVCNCTVLNHKPALVKHMNTAKHVQNISSKSQTIPIQQMLKPKPEDELRKRAELKICAFLAHHNLSFSLMDDLIPFLKNTLTDSNTIKSISLGRTKATNTIKTVLGLILTQELIDKLKKTPFSIIMDETTDISVKKQCALAVIYYDEVDCVRTQFLDIYEVKSGKAEDLCNSLLTWLEDRQIPLKNFVGFASDTTNSMVGEHHSVFSHLKQKVPHIACIKCSCHMIHLVASKACLKLPRSVEDFLRSIGAHFSRSTKRQKKLKEFQDFFGVDIHKILSPATTRWLSLEACVNRTLEQYQVLVFHRFEMSNETQIVQWLDEVSDEEQDVAGSDSEDETVNDAAIDSAHDSESEIEESEDIQNISEPSEDKIKARFGRDRDALPSDDTEMNAFLGLLIMAGVLRASHLNFIDLWAQDGSGQLAAALVTDHQKRRIQLRAVPTTTKKRLREVHDVDETVQQSTAKRGRCSSCPRKNDKKLTKNLHKEWKKHAFLDFSELNMSPDLPVEEYWNKILKMTDGTGEPMFPNLKEIIKVLLVLPFSNACVERVFSQLKLIKSDQRNRLNADTIAALMATKAAVKNATTFEPSKALMHAKIKCNTDGDGDGEGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSJ5</accession>
    <name>A0A835GSJ5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSJ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="150" mass="17175" checksum="DE3F84949BBA1ADC" modified="2021-09-29" version="1">MNDPQPSTSQKDVDVFLSPRKNRPRKAFTVTEKVMIRNAYKYVKNEISAQLEAFEVVQENECVSKVANILGITSRSVCNVLKEVKKGTPPTPPKKSGPKRSFKDKIVEFTFCAIRRIVHQFFYRNEPPTIAKVNQALRQCPFIPTSLIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTZ5</accession>
    <name>A0A835GTZ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTZ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001606">
        <property type="entry name" value="uncharacterized protein LOC108091111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF12">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 14, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032619752" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="223"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="392" mass="43169" checksum="A881848F5E3D40BE" modified="2021-09-29" version="1" fragment="single">YEALRGAEPRPGAMWSASVFFLTQFVVCQFTTENPTTPTTEESQTVTTFYALSTGIVPAPVMLRLGNSTIDSTKAFKVPQPSQDPSTEKPLKVDMVPHVVLKNTYFDHDRKYGPSFEDAPDGNITKITVQLGEDAHLNCRISLLQDKTVSWVRRRGKDEMPELLTVGAVTYAADNRVTVARRYPGNWRLLIREVKPDDEGVYECQISTHPPRVSRTYLHINTPQVWVVDEAGAPLLEKYYEAESTLALLCRARHVETPALLTWLHEGRALNADTTRGGISVKTEQVPGGADSQLRLARVNSSDAGNYTCAVRGARSHTVSVHVLNAESLAELHAGSKSLHPSTVTTVISLLTVLYVAKGTVLFVPAIFFASLAHNMIQAQGQTNELYILLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYL5</accession>
    <name>A0A835KYL5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000367">
        <property type="protein sequence ID" value="KAF9408695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="529" mass="61134" checksum="D0865056B735C794" modified="2021-09-29" version="1">MSSQKENTRICCMCGSSPSKDPRITLYRFPKPGPKNAQRCELWAKYCFPNEPWSSTKFQDGLHKQHKMLCSKHFQSTCFIDKKMFRTAVPNVQCHKKYAVKSDVENDLGDVQNDFEDEQATSSLIETPAPLVYKRKYSPGTPICRACLTTRRKLYSIQDSDVLDAYQSLSGTEVSEDDRLRTGSAVIALFHYGNARDEIVNEEVVEDVENKDPDLLLFDKKIFRSNQTLRILSDPIKLEEFQNLYHVDAHKLSHEEKTQDVLDRRDRTNYLNSPFKCDMCFKGFMAEDFFVEAKKHFIEFHQRKLSTTCEYCGLEFCSTPKYLQHVNDVHPNELIWCNMCGHLFIREVSLEKHKKRRHRNLHLSSSCPHCEVQLVDGAALDSHLFPGICSRYTCVHCGAGHSDAMRLRNHILKAHNKRNCNKVYKQGAHLQNHLKYVHYKVNRKVVCEICGVVVATNASLKVHMRHHTGERPYQCPRHRNTVHTTLRPFACERCPKAFKKKDSLLSHEQKVHDIRMAPPGELPSLGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYZ0</accession>
    <name>A0A835KYZ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000577">
        <property type="protein sequence ID" value="KAF9406548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="30818" checksum="A5C8173523AD1B40" modified="2021-09-29" version="1">MLFLTLVHSTTSFPTAIRLPSACARIIVQGVLSLRADMFLLYVRTGQDWNTILSSISRGASGLPLNSSSICCKVFPLVSGRSIEITSKQYVRRPAYMQYVPCMPTLSTKPKKVFNTKKKEADIVAKLMLPPILLYSRGNTSPPITFGNGSMPVATVKNCRLINSAGIQTASLLPAEDRSQHVHEEYAKGLCQGDGGEKGSSVLWAGVLSDEDRSQRREHADREALEYSSDNLGHRYLRVWYEQLREQDGGVPDHAAVADDVAAHRCRHETLQEEQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZK8</accession>
    <name>A0A835KZK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000460">
        <property type="protein sequence ID" value="KAF9407543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZK8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="62" mass="7431" checksum="6A14978C6143969D" modified="2021-09-29" version="1">MADPLHKFPNPNSFKVEQIDRFKSWKAILQSADQEKGDEYICKKIRICSKHFIESFKYRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZT0</accession>
    <name>A0A835KZT0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_004575</name>
        <name evidence="5" type="ORF">HW555_011617</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000359">
        <property type="protein sequence ID" value="KAF9408812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000252">
        <property type="protein sequence ID" value="KAH9641188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZT0"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9641188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="146" mass="16903" checksum="84DD8E1C38984A90" modified="2021-09-29" version="1">MKYNKLVTSSRRKNRKRHFSAPSHIRRVLMSSPLSKELRQKFNVKSMPIRKDDEVQVVRGHYKGQQVGKVVQVYRKKFVVYIERIQREKANGASAYVGIHPSKCVIVKLKMNKDRKAILDRRAKGRLAGKDKGKYTEETATAMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L151</accession>
    <name>A0A835L151_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable inactive acireductone dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_011990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable inactive acireductone dioxygenase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">This enzyme lacks one or more conserved metal-binding sites. It may be non-functional.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000394">
        <property type="protein sequence ID" value="KAF9408266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L151"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9408266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="170" mass="20062" checksum="D6F68C57F7D45FC7" modified="2021-09-29" version="1">MVQAWYMDEEKTDQRLEHHKNPPEFISLEDLYKKTGVEYFKLNVDTYTTDGVLDKLKQERGYTYEDEMTCSKECLPNYEEKIKSFFTEHLHTDEEIRFVLAGSGYFDVRDGQDQWIRIAVTAGDMINFIKAKRFFIGEPVWLPYNRPADDMDARKQYVEKLAKGFPVTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Y9</accession>
    <name>A0A835L1Y9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Y9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="308" mass="34335" checksum="6A5F0696ED31DE76" modified="2021-09-29" version="1">MSQLAEVLSAQKTLEESFIKKMNALEAQIQTAGPAKDTVAKVAEEFRAFRELVFGMLGLLRRQISECAQQIDEIETRSRRKALIVQGVAEAASEDCTKVTLDVLNSKLGLGLTASSLKVCHRLGQANTNHHRPILVKFASVEAKMKVWRAKTGLRGSKLALKEFLTKTRQSVFGKARQHFGMRSCWTLDGVIFIKAPDGSRHKVMSLDELGLLLGRYPRAQDTSTSADKRATEVLGGLKGTRKMSGSQSTKRKTWDEEKMAQAIKFVREKKMGYLKAAQHFQVPRTTLFRLCQKDEQSPEVAAAKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2H4</accession>
    <name>A0A835L2H4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_015068</name>
        <name evidence="7" type="ORF">HW555_008741</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000259">
        <property type="protein sequence ID" value="KAH9640972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2H4"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000018">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9640972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="26070" checksum="32F5020AD7556D24" modified="2021-09-29" version="1">MSLEEAKQFAAHRAVDEYVKKDCIFGVGSGSTVVYAVQRLAERVETEKLKVTCIPTSFQAKQLIIKHKLTLGELETHPVIDVTIDGADEVDADMTLIKGGGGCLLQEKIVASCSKKLIVIADYTKDSVKLGDRYKKGIPIEVVPMAYVPIQNKIQALYGGEVKLRKAVAKAGPVVTDNGNFILDWIFTNQDLRWDKVNSIIKMIPGVVETGLFVNMCEKAYFGQPEGSVIERFGVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L446</accession>
    <name>A0A835L446_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Dynein beta chain, ciliary</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HW555_007725</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">BAW_Kor-Di-RS1</strain>
            <tissue evidence="27">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000945">
        <property type="entry name" value="Dynein axonemal heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="17">
        <location>
            <begin position="207"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="18">
        <location>
            <begin position="1410"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="1948"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="23">
        <location>
            <begin position="2432"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="24">
        <location>
            <begin position="2758"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="21">
        <location>
            <begin position="2900"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="20">
        <location>
            <begin position="3173"/>
            <end position="3514"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="22">
        <location>
            <begin position="3542"/>
            <end position="3759"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="3932"/>
            <end position="4052"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="25">
        <location>
            <begin position="4084"/>
            <end position="4220"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="26">
        <location>
            <begin position="4228"/>
            <end position="4318"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="26">
        <location>
            <begin position="4320"/>
            <end position="4463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3394"/>
            <end position="3442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="956"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAF9414328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="29">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4465" mass="513597" checksum="69BA4EB2C5EF44D9" modified="2021-09-29" version="1" fragment="single">[encoded data, 4465 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4T3</accession>
    <name>A0A835L4T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="733"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1093" mass="118517" checksum="821768E5A64CFB83" modified="2021-09-29" version="1">MRHFTQKTLTSRHEPCLHVKVKRRVEESATETETTIIKTNAAAAASSGVVVENGEKGTVAAGSAAVAASSSTTIIKSEHHVSKCAVNEIYSECPEKLCEPQICEDVGIPQCSTHDKRRFDKSGPCPGPPACICVEGFVRNDNGICMPAKECPSCGNDKNATYGCGVNCGRRCSNYMLSNVICADVCYTNGCDCKKDYVFDDYLGFCVLPQDCSNKNAPEPEGSEGSSGNEDGNEGTDPCVDCSANNCDVTTEKTTDLEEMACNGMDRETTTESKTDSSSITESNEKTVSTTEKSEMTTKGSDKIVIQSALVGIESGGGSDSTTEQSHMTTESRSTTEEIEMGKTTTSESGKESTTEKMATVMTTAAESENGLTTEDETGISMTTEKSPNGSTTKVMESGTTIAAESGKGSTTEAETNITTEKSLNGSTTKAETNMTTEKTENGSTTEAEKDITTEKSENGSTTKAETDMTTEKSINGLTTKAETDMTTEISENGSTTKAETDMTTEKSINGLTTKAETDMTTEKSENGSTTEEAKSNITTDDSKNGETTEHSLSNQSTTTKGAISTTTMITLKPITTTKIPLTTTISAPETTMKTTTHTPSTTKAPITTTKSVTTQTTPTTEASTTKGPKDCKGRNEWYYDCAPSCPQRTCEDYLNGVRCQASDRTTGCKPECRCLVGYFKDAEGKCVSRLECRKSSSSTGMISTTSISTTEEPTCEEQAIPLFAVGSLGYTLKLLYEISLSNPGHSVMVGGASVLYLMGQLALYAKGKAKTELLNVFNLKETEQISCAFPKISAALTMEYSDIEFSLFCKIYADNECAMTEEFISKTEEIFAMAPENLDFTSSKTAKTISDEVKRMTNGNFENYLKPKISATLDHLIMIDAESFQGKWEKQFNPSETTLKDFYWSGRISKVQCMYQKDTFLYLESSALSAKVLRMNYVGGMFGLVIFLPNSFTGLNDLLKKLQNTNAVYSAVSSLTMQMVEIDLPKFEISVANRLKKPSEKAGVTRIFSNTSLGLESVASCEIPYVSEILQKITFHVDEYGMGETWDVDFPPIETTKAPRRQQTFRFKADHPFVYSLFHKEVMLQAGIFAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L522</accession>
    <name>A0A835L522_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L522"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="582" mass="64430" checksum="267BBCE0DDA0CAB1" modified="2021-09-29" version="1">MITCTARERIQFTSENEKTYLSIRQTEYGHASVTNFIIAQAQLTSEEIKTAKGSEELTEEATAVIEEEDVKTTTELSVTQEDVKDKEDEQQSAEMVTEEVSVDVTAASSSNVVDDVGNIASNLSNNIETVAKTETVPITATTRAMEEEPSPKIQETEEEETPGQRNPKADTDPKPPLDKRNFDTQPPFKPQTTRSVVRSWLQDCCVRPPAGIMVPLRAAALARALAVWSDLTVPALNLSHVLVMGYDSNGVNWRSRHNLQPSSSSNEKTVAEALSKLLLKYQGVNTETTNDGTMRALATAAKLVPYDSALFVITDKGPGDPQRLPLALRALVEKRLKVYTIWTDPAHPSPESEEALQELRNVSKHTEGEVMPYPLQVMDIEGTSNLAAETELEQWSPLDPKQGRRGRLHNDLGLEKLDLLLVRRGAEQAISLGVPVENGVTALRVFIEGAVDHAVLYPPNDAPQIDLYNTTSVAAFSSTSRTEGVSPRDVYLVFPGTKYDLDMLSVLPMSPDRPEDQAAYVGMWHLSIRCETCDYRLMVSARTHIHFDVETDTPDYGILNGRNFVKFLSHHVSKSQLLMMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5C1</accession>
    <name>A0A835L5C1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Timeless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5C1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF5">
        <property type="entry name" value="PROTEIN TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Timeless C-terminal" evidence="6">
        <location>
            <begin position="898"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1275" mass="143903" checksum="4751B4FD6264834E" modified="2021-09-29" version="1">MEWVLRSPQIHSTFSNLGFLHADGYHVNENCNAALETILHNILTEDKYLRTYRRSISFGQNIKKDLIPLLIHAKEDATIELLIRILVNLTIPIECLLSVDVISRNDFGRHTIFEINNLLASTKVAFTDHRATKVVIDFLKKNVDCEQKSKLTSEQCTNISNSLLLLRNILHIPEEPSGQSPSYNGPHAVQNQILWNIFSQSIDKILIKLMIIPDANKWAVTMVQLIALLYKDQHVVTLHKLLNLWIEASLSESSEDNESNTSPPDRGSDSSPMCTSEPTSDSSDTGGSGKSNDDPNSVNKDWDASSQMNNTSENGNPPFQTTEEKESDNEDKNNSIESNNDEIVQSDNGQSSSCSGGAQSSRNGQGQQPGNTEKKTVISENSDCGYGTQIENQESISTSSNEDELPSKKPVHQKPHNPKQRVNNKARSGVTMQDRKRKKIVKRGKSNIINVQGLSHKTPTDDDISNVLKEFTVDFLLKGYNSLVQTLHNQILSNLQLEIDTSHFFWLVTYFLKFATQIELDLENVSSVLSIDIVSYLTAEGVNLCEQFELAIKLDGNDLKPNIRRLHLVVTAIREIIQAIDVYKKFSHICKEDQEALLKLQLKMCETEELRSLLVLLLRHYNPKYHSKQYLQDVIVTNHILLMFLDSAMKLPEYNGSTNMLDHIRQFASSEIMYQYGLLLEDYAGNGEFVNDCIFTLMHHVGGELESLITLFQPKILKTFTSIWKSEFEICDDWSDLIEYVINTFIKKPHSLQSSANFRLDIENFDDVKIIPKPMVAPPAQSKSETVEAEEKKPTTKSNTSCISNGKGESRWTEDELSSLSWNYMQCSALPDVVGEIITLYKEDGIIKSRDSVIKELYTQNLINKEDYDKFVKGENDRNIKTVQVMKEMRDDEINKLCEQLTQDGKSKFLDWVQKVLLETCFAKIYLDKLARKSEGDNTIEENETKLSKLKKSNDLHILSPVSYHSLLMNQSIPLVPWNCKQASICKDLKFLQLLHKLGFHMPVDSGKVFIRIPHFWTADFLYDVAGKISPIDKSKLKFSINDISDSSISNSMQQENLLLLPDLTKDISMIENSDNFYQIHKQKHLATMVNFTPMPSSSFNSEGGDVDKHNWLEVVQKSQEYKIALNLGSSIIKSDEEAQSDIVNLQQLPVKDTEVSVPPLLLATGPVAIGSTATVTGASFPASGLMMPTIMSIKQETTHFNLPVPDSEHYSVCETASVASDLTRMYVSDEDEKPEVVRPIIAVNPIHDESDELCGDLDDDNSGKRPRVNYFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5H1</accession>
    <name>A0A835L5H1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5H1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="306" mass="34147" checksum="C3BA040A4A42B5A6" modified="2021-09-29" version="1" fragment="single">VEVKRALQKIEKDVADLSKAERPPQQEQGPKTFAQVASTPRTPVTPAKGPNHTLIVSSTNPQHTGDNAIERIRDALDLKATGARVDAVRKARNQKVVLRCASKTDLGLIKDQFKSSKGLKVQEPKPQNPLVCIRGVLTSYSDEEILDLLKAQNKHLLQNLAPADQTVRMRYRKRARNPHECHPVLELSPKMTPRKGTGVEMDLATREANNLLQKGKGALEAAGNMKRECKTATYECLQGLYETVLSLADSRARHKYNLERAHNRDVMALKAELSLMRTDLSDTKKEAKGIREWLGHETLDAFKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5X4</accession>
    <name>A0A835L5X4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="74350" checksum="48F8257A7E957DC5" modified="2021-09-29" version="1">MKFPKNEEMNKKWLDAIPGNVTQYSAVCGLHFKAEDFETNPVATRKMLKANAIPSMNPVPKAELSMGAKTSEQVNKSRSTVKCDVCGRRFMNLQALISHKKFLHTRPDTARRAALKKQENARLTKKVIPINMLKRVNPPTPAKQAAKSPVDQTRNLAGKDTDQPKKPHFECPVCFKKFPVYFTAFRHIQKNASCCIDEKGAKVSPNSTSLVKPIRIEICSTCKDETRSTEPHDCPKSPSSMDQYECLGCKQVFNGLLLYQHHVKGLHSDGAQNYFFPEFTSWKKSLQEQTKVEYTRLNRQKTKEVYHCSHQPAGVTDNTQLCPSMIIARAYSKGVHVSYLTDHQGHTVDSSPIKKYSEYAISLYLRDLEDLKESTEDSDLYSQFKNIIMSVAHGAAKADMSTLKELIEKALEMTALLKNLNKNDHNVSTVKKKLSDAQISKTLDSLQTKTGKRKQSVEVKETKRDVAKRIKRNSVAIEDTVENNIATKSKATPITKSVTFRSETVSDSELSQDGAEDTLETMTESIKEVHKTIKKTDNALETSTVTKVKDDSKKNKLQSPSFNDTYMNFVDQNFKCKLGSSTPKVRPPIKKKEIMKTKIGQFKVKSLSPKEPGSPKSPKQTKTIEVKEIITPKNWTTKDIKYEVKEQENDYNILILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L681</accession>
    <name>A0A835L681_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">XPA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L681"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="11">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="269" mass="30627" checksum="A846DC75939D67DF" modified="2021-09-29" version="1">MTAVESSDVPHLEVEKAEHTSTAAELSAAQRARIERNRLRARQLRDARLVARPNNREPITAPIAATDSGGGFIPEVEESSLPVRAVPPPAPIVDPTERPQCLECDQLFPESYLFDTFGYNVCDECRDDDGAHALITRTEAKNSFLLKDCDLDLRPPALRFVRRRNPHGSRLGDMRLYLRAQVEARARLVWGSDEALEEERARREEARVRARHTQTSRRLRALRMDVRSSLFDKSRALHEHAFGEEKYDEATDLYSRSCACGHTETYEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6X7</accession>
    <name>A0A835L6X7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_006855</name>
        <name evidence="3" type="ORF">HW555_005916</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000661">
        <property type="protein sequence ID" value="KAH9633253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6X7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF231">
        <property type="entry name" value="CLAVESIN-2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="102"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="38145" checksum="DB15BA2929F3AEBD" modified="2021-09-29" version="1">MNEYAEYDWKLHQMQNERLCEAARKRLTDGDRQRALNGLRDAVDKSLNLALRDKSRCQDDNFLRRFLYARKHDVQQSFELLVSYHQYRREHPELWATADGGVLRALADGLPGVLSQRDRRGRCVLLMFASNWIPHACPLLSVFRALLLTIERTLDDIQNQANGYVIIVDWTEFTFKQSCNLQAKVLKMMIDCLQDCMPVRFKSIHFIGQPWYVETALAVIKPYFKAKTRERIVLHGNNLSTLHDALPLDILPAELGGEGPSYNSELWLQEFCRGENINPTPITTTVTPILPIENDPPSAKLDKAYKQKDNPNFSFHGNEKSAKSELLRDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L763</accession>
    <name>A0A835L763_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L763"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF93">
        <property type="entry name" value="GH07959P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="37171" checksum="836BC3562E3BE12B" modified="2021-09-29" version="1">MGLAMFNQKIAISKLARELLFEGYDDQLLNLAKSLPSSTTGGAPPVDKFGWFYERNNSLDTDGYMEVTTGRAAGTLPGQIMRWNYEDHIPYYEGDCAQLTGSAGEFMPRNLTEDSVLPMFVPDLCRTVYMEYVDTGDQDGLTYNKYALTQRTSTSPSNTCFCNGECAWSGVMNVSACRFGSPAFMTLPHFLHGDPQLREMVTGMQPDPDAHSFYFAVEPKLGVPLDVAARFQLNIYLEPSENVGLYEDVPRMLFPIFWVEQRVRVEDDVIAELRLVRAIFDWGGTVCACAALVFAILVTIATCWARKPHQIKKESMFEKPKDEAELKLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7A0</accession>
    <name>A0A835L7A0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="124" mass="14387" checksum="5422AC1B1DE3587D" modified="2021-09-29" version="1">MRTSEMAVGYRKTQNVPKENDEDLDKNLVTSTLYCTCRDCKKYCAHKKPVTCIDPFLINMRHTYWIYRGLVTASMTQRAYMINTANAHQGNSDAKDNKTTIKENKTNKSKMKKKPMNNNKIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7E0</accession>
    <name>A0A835L7E0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_005433</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7E0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9417430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="484" mass="55965" checksum="34DCC95C56C561A2" modified="2021-09-29" version="1">MITLYLLLAISLALYGVYLVSKRKFRYWEKKKVPHLPPKPIVGNFAEYILQQKYYGRVEQEICNKFPEEPYVGSYFGTEPALILQDPEYIKTVMTKDYYFFSGREVSSYSEKEVLTQNLFFSYGDRWKVLRQNLTPLFSSAKMKNMFHLIEKCARIFENMIDQEIQKNENIEVRALTGKFTMDAIGNCAFGVETWTMVKTDNNPFTKIGDVIFDTARLRALKFVARSIWPAIFYACGGKSFPVDVDRFFSNLMTGVFKGRDYKPTSRNDFVDLILKLYNNKTVTGDSLTNMKGESGKKVSLDVDEDFLISQFGEEHKAQELAIQDVDNYLQRNDNVLKYECTTELPYIEACVDEALRLYPALGVLTREVIEDYTFPTGLKLEKGLRVHLPVYHMQHNPKYFPEPEQYRPERFLGEEKKNITPYTYFPFGEGPRLCIGMRFAKMQITAGIITILKKYRVELAPGMGEKVQFEPRSIVTAPIGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7W3</accession>
    <name>A0A835L7W3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7W3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="356" mass="39813" checksum="C8DC2C1922C77349" modified="2021-09-29" version="1">MKLCVNVMFPQDTGQIKLLFYSSICDANAALQMASRSRKLIELATGVAQIDNTQDESENAKSSSNTMQISTEGKDVAIDSIRPRSSSTSSSSSCSSCSSSSSRKSSSSDPSIYQAQSTKRAEYSFDTDVEEHITTNYNNISDDPNLVTSNMASINNDNYEEPLSSTNEHVLNDFGVIENNESSAIESIGNENTVSPIVYNSSPTKTGKKRRLNEATWKVNVAKRLRNSGKPYQSTKSKKNMPSRAIEKQWTFIANSVDIVIPKQRYVKVDSDGNMVKVQSSDPDAIFFKESYADELFKKAIVVRKKRYHNNQTINLDLQKAYLQKPGLAERKKADLMDLVNKNLIPRYHKPFYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8E8</accession>
    <name>A0A835L8E8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rabaptin GTPase-Rab5 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8E8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000005">
        <property type="entry name" value="RABaptiN (Rab effector)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rabaptin GTPase-Rab5 binding" evidence="3">
        <location>
            <begin position="222"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Rabaptin GTPase-Rab5 binding" evidence="3">
        <location>
            <begin position="410"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="573" mass="65533" checksum="3B6251BB58FCAD7F" modified="2021-09-29" version="1">MNSQSKMSNDTAESAKVEAAAECNGPSPDETRRLLEEEFNVQRAKMKELFLQKEEDMRKMLQDKEQLESEVLGLRAELQQLQTLSENQKSEIQSLQMLVSETVEASSSGTEEVRRLRARNLELEQHLNQMRQQQQEVSLAPATFVRSLARKLGADAEEQQPRKEEELLRSIIQPLEMEISALKSKLRETDAQLQDAMAKAKATAAAAPSGDAKPEAESSRQCDMCVNYEKQLVLEQTKAEQARDRANMKELALKQATEELEGVRSLHDETVRSWQAERQAAAQQLDALQAAVRAAQAALQRHHQQADEASQRALQLVTELTVDRETLQKKLDSLERDNAMLIGQYTKKAAEMQNEVIDLPDNVEELQMHTLRLREQLIFCQLGREEAAAAERDLRAQLLDHGELFHRQEAELATLRAQLKEALEEVDRLQTEQAQMKELGDKLRQSSELAEQLLEDKRRLQADLQDVRQRVSVLQQELDNSEKVQQDFVRLSQSLQVQLQRIREADTEVRWQHEDDVHDCPTCHTHLPNNKKKHRPAALARLGLRPTPTRLDLIRLPPSSHRPSCEHHRASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Z1</accession>
    <name>A0A835L8Z1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Z1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="133" mass="15190" checksum="6B46E63CC6132FDD" modified="2021-09-29" version="1" fragment="single">KPMTFGRIANFNWNNCIESNGTNINRTMTENRKRSREDDSCEFMPLSKRINNLHINNNLNTAVTQAQDASLSQVNGINTENGISSPSSSSGSERRPSYDPGMNSNQSSYYYDNKLLFELHLERIQRCGQQFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9J1</accession>
    <name>A0A835L9J1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9J1"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="396"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="451" mass="48874" checksum="279266C06CD5BF2A" modified="2021-09-29" version="1">MKMRKERDTLGELEVPDDRLYGAQTVRSVMNFPIGGKEERMPYPVIVAFGILKKAAAKVNIEYGLDKKLAEAIMQACDDVISGKLYREGHFPLVIWQTGSGTQSNMNTNEVVANRAIQILGGKLGSKSPVHPNDHVNKSQSSNDTYPTAMHIAVAMELRDRLMPGLVALRDTLKAKSKEFEKIIKIGRTHLMDAVPLTLGQEFSGYAAQLTFGIERVCSILPRLHYLALGGTAVGTGLNTRIGFAEKCAAEIAAITGIPFETAPNKFEALACHDTMVEVSGALNTVACSLMKIANDIRFLASGPRCGLGELMLPENEPGSSIMPAAQVMGNHVACTIGGSNGHFELNVFKPMIVANVLRSIRLIGDACQAFNKNCAVGIKANKERIDKIMHESLMLVTALNPHIGYDKAALIAKTAHKEGGNLKDTAVKLGILTPEQFDQWVKPEEMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9Y9</accession>
    <name>A0A835L9Y9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_015531</name>
        <name evidence="11" type="ORF">HW555_002725</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000526">
        <property type="protein sequence ID" value="KAH9635957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9Y9"/>
    <dbReference type="SMR" id="A0A835L9Y9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000019">
        <property type="entry name" value="60 kDa heat shock mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9635957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="572" mass="60961" checksum="F0536180F369FC45" modified="2021-09-29" version="1">MLRLPRVVRQTVSFHKNHQLARFYAKDVRFGADVRALMLQGVDILADAVAVTMGPKGRNVILEQSWGSPKITKDGVTVAKGVELKDKFQNIGAKLVQNVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPIEIRRGVMLAVDAVKDKLKVMSKPVTTPEEIAQVATISANGDTAIGQLIADAMKKVGRDGVITVKDGKTLVDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALVLFSEKKISNVQTIIPALELANQQRKPLVIVAEDVDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKATLSDMAIATGGVVFGDDANLIKLENLQASDLGQVGEVVITKDDTLFLKGKGKKSDIDRRAEQIRDQIQETTSEYEKEKLQERLARLASGVAVLHVGGSSEVEVNEKKDRVNDALNATRAAVEEGIVPGGGSALLRCIPELSALKTANSDQATGVEIVKKALRMPCMTIARNAGIDGSVVVAKVEDLGPEFGYDALNNEYVNMIEKGIIDPTKVVRTALTDASGVASLLTTAEAVICEIPQEKEPNPMAGMGGMGGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAD4</accession>
    <name>A0A835LAD4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAD4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051295">
        <property type="entry name" value="LGI_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367:SF318">
        <property type="entry name" value="LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24367">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="713" mass="81340" checksum="6B0BF10DA2207693" modified="2021-09-29" version="1">MQLTRPGLLAKSTVSTVVKNASCSRGWLRLVVQSIFAAITVASFILILLMAVPTWPSQSLPPPPPPPIPARCRIENCRIFCLDTPYFGEYEDHIIRAIMTVEENNCVQIFLTLESPMFIDNTMPPKWLDRLRTNNIHELTISNGNLAHIPSDAFMSQCCTNIRVLEFKNLRLKSWTPDSFVGLSNLEHLFIKNIGLYEIPRDALRALHDTLGSLTITRSNYWSPQNITGVTIFTRLESVDFSSNNFKDVLDRNSFIGLRKCKILYLNSCGITSIGAGTFDSLVNIEMLFLHNNQLTTLPPGLLSNAIGTSDLRPRINLQYNLWECDCSEEEIIRLTRQDVLLTDPVCDSPEYFQNKTFSELEEYCSDNLDFAYGNIFKNASNDASGARWWEYIDDICGFFYVSQRCFLNYPLSSGLRMLSPVHGHRCISNDTESINIIPSFISSNGTQIMPEKSWIKMNYFIKTHQYSVVEINATDTVNYGLIWYQTNCPNELYCISDVPSVFRIYNIDKNAEYVFCPIKLSSGQVESQNCVIYHNNSLFDFEKGYYQIEILLYIVTGMVCLIFGAICVYAVIRKHPHLLKGSKRILFVKHRSVDALVLPPKVPLRNDLSELPTNESSKKIFVVPANHINNVPSRFKRNKSVRSNKSSAPSYISALQPTEDQLAEWRIRHHFNNDLSINSMTSELSTFSWVSDDEGLYYSIDVDNYKTYESVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAF3</accession>
    <name>A0A835LAF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Locomotion-related protein Hikaru genki</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032521686" description="Locomotion-related protein Hikaru genki" evidence="7">
        <location>
            <begin position="17"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="179"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="279"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="338"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="397"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53481" checksum="C3F984B6263755DC" modified="2021-09-29" version="1">MFSPLLILLFTPWIFCENDENVTYSQDDFKCSLPDVTSLDANLDITRFRSDFSKISEVKFPGLIGPLNERLICKIKCIDGNWVGPLCSNTPDGRFQPILRECLYKNEHPLLAISFKNSSINKDTHFPHGSVLVSRCKHFGLYKMKGDNMIHCENGEWAPKLPECVPTSVVTNFTGDAPPTIQYTIVSGSAVVEHSGELFVFPDSTIRLDCVSRRALGDPEWSWTQAVGQHTSAWSSEEGEKDSHYRLTLSKMSVRHSDQYTCTSPGGHTNTVSIKVVNVVCPPVVVTSQYIRQFTQGTKLGNSAHFSCQPGFHLNGSAILTCMGNGRWSSLPPTCEETFCPMLKTLGPHLSVVEYNSSFGGRAMFQCSWGYRLVGAPGLECEMDGKWSGEVPHCIPIYCPGPLVPTNGRLLTEPSVKHGKYPVGDLMIYSCDDGYEIVGESSIVCTENGFWSHPPPFCLPPSEIRKTDTIYVENTTLIHIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC31</accession>
    <name>A0A835LC31_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC31"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032398105" evidence="3">
        <location>
            <begin position="20"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="802" mass="87978" checksum="C7F003CDB5C85B9B" modified="2021-09-29" version="1">MIDIKIQFLFFNYIVFAFAEDYESDDKLYMLVSQDQHQHTPRLEDFFWTGSGDGPPPPPDPPLPAPVQPSTPVVRTTTVLATVYLDSYPPQAVTDKSTGECVLNCGEPGVPGSLEPEIPDDRRYWLLTVIQGSTPDSLQLRLARLYQKAFLRQQERHLGIIKSLDAPPARKKHDVHSFAVNKDNNISPVGPQGTYSPFKYVDIDASMVPMESIVSTMVNNDENSSTKALESSREFVYPANIEMFSIDANTLTLNAEIKATKLNEVESWILATPTVSIRKREITDREQLEEIKEDSIDIPLELEANETMLFKREILKPEQQPPVQVHIQNITESPETGSIQIVYVVLVGGRAVPAAVAARDMRLVRDAEVARELGAVVTTKAEPYLKTAEGLEGDAGGGVHGTELWALAVGATVAILLLLVLLALLCLAHRKKTMKSAASIRAYRNELLREAERNQLKQVHEEKDGRLISVVSPSRTRPSSTLLPIYRAASAASSSSTTSSGVSEVATAFRRRQKKPHALRMPQKKRGKGNVVEPLSRILEPVSVRHLDIDSPPVSPKKNKESNKDVVPRRQMASQLVRLGSIDKDPGVIGPLVWDLHCQRIKDSSKPSSPARSATSARKEPGPSRMRQRFNELMDDAFTLFGSVGSSPNSQDTYTVEERDPKDKGTQNAGVATDPSEQLAQARNDNVRLPGSPYTAMDTLRGRSAGPGRAGPSTSTPVQAEGARPRTSFTRTAAERRVPPPTRAWGQTPPQSLGGRPTVNPALITAEGRLPAEDPAIPLISAIKTEIQRIKETATKPSTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC62</accession>
    <name>A0A835LC62_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000326</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC62"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="14">
        <location>
            <begin position="534"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9424515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="89194" checksum="064538935A16C082" modified="2021-09-29" version="1">MDVKMHDLRSYPLNFFYEFVIGSKPLACNLPPYACYECAALVSKFYNFRQKCLRNQDVLNEITAIYGKLHPAKVRSINRKELNLTSKLTIAHLENIDTTSNTSTNELVPLETEECEESSVNEEWDHDYINIEYIDNSLFSDDDEPQSINEEENPKTKESNEKPLEDMLDHVEFGEAIDETNPEECVEVKTVDTTKKKHRRGAFKHVTMLSNPSLSAEDMDDFDQYINVLKLTVKEQKEEVRKRKQSSNYLNSPYRCKLCYKGFINNNAWNHHVSKHSESAGSLKCGICKIRFKTKRAYQQHVLGHEKKYACKFCTYVSTNTVWTSYMTHTRTKHPSEFICGVCGNSFISKLGLAMHKTMMHKDVQDKPEDGPYCGKCDMRFVSSAAYKRHIAVSVKHTQNTDSVNGCHICGATFDNSEELRLHHRKEHIKRRSKNLGKTPSVSNWPAKCEHCDKEVSSAREYWSHFRHAHPDKPYPVEKNHVCDTCGKTFQSNAVLVYHKRTHSSERLYKCSQCDKSFYNRSNLLTHKKIHSAARPYPCELCTWSFKSKGALSRHFRTHTGQRPYECEICGKRFTQSNSRKLHCCIVEYFADYAENVPTGDSCRALKQAAREAGVYVVGGTLPERCGDQLFNTCTVWDSTGNLVAQHRKVHLFDIDIPGRITFKESDVLSAGCSMLIYPGAFNMTTGPCHWELLGRSRANDLQLWVALVSPARDPCAEYVAWGHSMLINPWGAVVGELDENPGQLCCVVDLETLEAVRSQIPVRSQRRTDLYDTISCAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCG1</accession>
    <name>A0A835LCG1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCG1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="318"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="50227" checksum="21D149BC53231511" modified="2021-09-29" version="1">MQTTLCYFAKALSVMHHKTTRLQMYIRMEEATKPLQPVNGQKRKRKTKSKFTASQQKNEKFDTSTESAVIPEKKAVSPTKLAKLQGNSVGTKTKGKLENSADSEVSPEKKSVSPTKTAKIQSNPVGKKTKRKLDNSADTATTSEKTAVTPAKVAKTQNNSIGTKSKQNDGKSDGNDRFPILKNQELISKFLKVPMSNNQKGRIRQAIKASLQGTSNTIQPEIIHNKIQSILNESPNPTDSQLRRIRILYNLLKTSLEGKDKKVEFKPKVKVEKDKPEKKEKIKKETEDGLTEKEKEGKNDKGEKKEQVAKKVKGPKRYVVFLGNLPLDIDKDKIMNHFSEMNEHIVDIRIPKAMDGKKSAIAYLELSNEPSYEFALSKHHSMLGNKRINVLYTAPKNGKQSKTSAKGKSAKLIALQKSGKLVGSIPLAKKRSQRRLKMKQAQAKLAAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LD87</accession>
    <name>A0A835LD87_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_003467</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LD87"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06612">
        <property type="entry name" value="STKc_MST1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000075">
        <property type="entry name" value="Serine/threonine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.170.10:FF:000002">
        <property type="entry name" value="serine/threonine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024205">
        <property type="entry name" value="Mst1_2_SARAH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11629">
        <property type="entry name" value="Mst1_SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="63"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="16">
        <location>
            <begin position="488"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9420246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="542" mass="61392" checksum="8F4E6A874941F6C1" modified="2021-09-29" version="1">MDSEGRLVFWKSGVWEGGAPTLSCNTCKKRRADRMSANDTERPQGELKKLSEESLTRQPEEVFDIICKLGEGSYGSVYKALHKESGQVLAIKQVPVDTDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWVRHSEVTICLIVMEYCGAGSVSDIMRLRKKTLSEDEIATILCDTLKGLEYLHRRRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYDCVADIWSLGITALEMAEGKPPYGDIHPMRAIFMIPTKPPPSFREPDQWSPEFIDFVSQCLVKNPEERATAEYLLTHEFIGNAKHPSILSTMIAEAREIRESQVFRNAQHQTNNAKTFAAGEGYEEATMKQRSDGTLVPTRDATTDLAADLGTMVINEPDADLATMKRHDTDPMDTNRPKYRPLFLEHFEKKEVNHLNMAATTNGTLTPAHRIVPDEDSVTAETESEANPALAFQRAFVEEGNFEFLGYLSVTELEDRVARLDAEMEADIERLRARYHRKRQPILDAIHLKRKRQQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G095</accession>
    <name>A0A835G095_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC-type glycine betaine transport system substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000858">
        <property type="protein sequence ID" value="KAF9404898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G095"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13610">
        <property type="entry name" value="PBP2_ChoS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.120:FF:000002">
        <property type="entry name" value="Osmoprotectant ABC transporter, permease protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058089">
        <property type="entry name" value="EgtUBC_SBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC-type glycine betaine transport system substrate-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="172" mass="19845" checksum="82E1A3EC9F88AAE9" modified="2021-09-29" version="1">MRYQNTYAVAVKRSFAEENDLKTIEDLKKVENQLKAGFTLEFIDREDGYKGLQKLYNLNLDVKSMEPSLRYQAIDNGDVNVVDAYSTDSELKQYDLVILEDSKQLFPPYQGAPLLKAETLEKYPELKELLEPLVGKITEEEMSGMNYQVNVEQKDPATVAHDYLVKHKMLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0A0</accession>
    <name>A0A835G0A0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000864">
        <property type="protein sequence ID" value="KAF9404866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08563">
        <property type="entry name" value="GDPD_TtGDE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="27902" checksum="C360CD33A167CC27" modified="2021-09-29" version="1">MRGSKGTHPENTLAAFREAIRVGADGIELDVQLSKDNHLIVIHDETVDRTTNGHGEISQLTLAELKKLDAGSWFLENPMVQEIPTLAEVLQLLVNEQFQGILNIELKTDKIHYQGIEQKLVQLMQSQNWSFDYMYSSFYFPSLEKIEEIVKDQKLAFVFFMSKKDEELAEKTSFIEGIHPHIQWVIDHIEHFVEFPKAIRPWTVNEKEQMLVCFKYNITAFHTDFPEKAKQIRKLIQNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G170</accession>
    <name>A0A835G170_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_014317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000964">
        <property type="protein sequence ID" value="KAF9404488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G170"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="110"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9404488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="423" mass="46120" checksum="6CF933F35077784B" modified="2021-09-29" version="1">MGLRILVIGSGGREHVIAEKLVQSPKVATVFCARGNAGMEKSGIKLVEIAEDNHPALITFAKENNVDWTFVGPEIPLLNGLVDDFNEAGLLAFGPKKAAAFIEGSKDFAKKIMNKYHIPTANHQTFFDFEQAKTYVFQQGAPIVIKADGLAAGKGVVVAETVETAVEALNDMLTKDKFGQSGSKVVVEEFLEGEEFSLLAFVRGLEVYPMVVAQDHKRAYDKDQGPNTGGMGAYAPVPQISEALIQESIETILKPAAKGLVAENRSFTGILYAGLIATNSGPKVIEFNARFGDPETQVVLQRLESDLAENIDDLLKGKQPTIQWKKNGFSLGVVIAADGYPNEYQKEIPLPDFSDVKTAHIYYAGVEEKAHELVSNGGRIYLVEASADTLKEAQEVVYNVLKNKNTTNTFYRKDIGFKGLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2E7</accession>
    <name>A0A835G2E7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000699">
        <property type="protein sequence ID" value="KAF9405676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2E7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18467" checksum="36949D9F4040AF8A" modified="2021-09-29" version="1">MDCNQRETEIDQCLDDIREEHSHFTPISTDDLSAGPSSSNVIVTEPDRRSRSSRTMNTVRQPREWKIETEIHNVSEFTNTIQPQSTYTIRWLDTRDVNILTTAHHPTDTVFVKRTQKDGTKKEVLIPTAIAQYTLTMGGVDHFDHFRSSYPINRKCRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2G6</accession>
    <name>A0A835G2G6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Putative inorganic phosphate cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_012961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May be an inorganic phosphate cotransporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000547">
        <property type="protein sequence ID" value="KAF9406793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000144">
        <property type="entry name" value="Picot, isoform B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="898"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1201"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="15"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="464"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="900"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1390" mass="154212" checksum="E54BBD3A5C269344" modified="2021-09-29" version="1">MTRPVLGVRHVQVLMLFFAMVICFTMRVNMSMAIVAMTDSSAGEGAFDWSMQIQSVILSSYFWGYIILQIPSGELAARYGGMILVTICIAVNSAVSLLIPIATYYGGWQLLCGCRVLQGLSQGCLYPTMHNLIGKWVPLEEKSRLGTLIYGGAQLGTVIQLVISGFIANSWGWPAIFYVNGATGAIWVVAYVFLGSDSPQRSKMISETERLYIQTSLGQVGEQKRLPTPWKKISTNLSFISLIVVHCGHNWGFWTLMTEMPSYMKQVLGVDIKANGVMSALPYLAMYILSFPFGFLSDYILEKKWLSISACRKISSSIGEYGPGLALIALCYVPAGNVTLAVTLLTVVVGLNAGHMTGYLLVHIDMAPNFAGTMMGITNFFANIIGIIAPLVAGLILQDETDPTQWHLVFYVSSAIYIVTNTFFIVFGTSERQSWNEPENNEVTSEAEKKAEKFQSKIFGIRHLQVLLLFFALVLGFAMRVNISMAIVAMTDKRSEDPFDWNMQTQSVVFSSFFWGYIVLQIPSGELAARYGGMILITIAIAVNSVVSLFIPYGAYHGGWQGLCLLRGIQGLSQGCLFPTTHHLIGKWVPLEEKSRFGTFIYGGTLLGTGIQMVASGYIADLAAIWVMFYIALGADSPQKSRIISTEERMYILTSLGQTDGQKILKTPWKKLATSVPFISLTVMHSGHNWGFWTLMTEMPSYMKLVLGVDIKESGAMSALPYFVMYILSFPCGFISDYGLKKKWFSINTCRKVSNSIGEYGPALALIVLCHSPVGDVTQAVGLLTLVVGLNAGHLSGFMLVHIDMAPNFAGTMMGITTFFANVISIIAPLVAGILLEDEYDYHQWQLVFYVTSGIYIVTNTIFIIFGTSARQPWNEDPDAGDAESRPKRKLGVRHIQVIFLFLALALAFSMRVNMSMAIVAMTENDIDGTFDWNMQTQSYILTSFLWGYIVLQIPSGPLQAKYGGKVLLVLCMVVNSGVSLIIPAIAYKARWTGLCFCRFIQGLAQGCLFPTTHSLVSKWIPLHEMGFLGSIVYGGTFLGTSVQLMVSGFIIQYFGWPTIFYINGTCGTVWSLFYMYYGSDSPQKSKLITTEEKDYIQSSIQVFEESKLANTPWKKILKSAPFYALLISHCGHNWGFWTLITELPTYMNNLLEVDITQNGLLLAIPYLSLYLLSFPFGFMTDVAIKNNWCSLGTCRKICNSIGEFGPAIMLIVLCQVPAGHVTFTVAMLSCVVGLSAGHLTGIWLTHIDMTPNYAGSVMGITNFFANITGIVAPVVAGVILTDETDVKQWHTVFYITSGIYFVTNLVYITFGSSEVQPWNDPDYVSTPQLQTLQRRKSSITDRNSMSRYLLKQVWEIIYIFSLNNISKTINKGILFHFKMLQRKFFVKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2Q9</accession>
    <name>A0A835G2Q9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000729">
        <property type="protein sequence ID" value="KAF9405495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2Q9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="23331" checksum="2B6756AA6771D525" modified="2021-09-29" version="1">MSQVSEIISIHKNVQESLLKRMGDIEAQIQSAGPAKDTVARVAEEFRAFRELVFDMLKMLRAQVIECCRNIDNLEMRSRRKAAIFQGMPELDNEDCSGLILGVINTKLGLDLPVSALKVCHRLGASNKDHHRPILVKFSSLDYNASVWNAIRPVYGALKSPSGNFSLSPDRRFSQKRAIILACEAVGLGMAISSSKHPMEINTGSHAWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G390</accession>
    <name>A0A835G390_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G390"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="294" mass="31712" checksum="F9362F0E46FFA807" modified="2021-09-29" version="1">MASVGAVTRILLGKHVVSRVAATNSGSIKFYSTAPAYENIKVEVVGSKKNVGLIQLNRPKALNALCGPLFVELGQAVRDFDADEKIAAIIITGNEKAFAAGADIKEMQNNTFSHNTKKGFLKDWEDVSNCGKPIIAAVNGFALGGGCELAMLCDIIYAGEKAKFGQPEINIGTIPGAGGTQRLPRYVGKSKAMEIVLTGNFIDAAEAERMGLVSRVFPVDKLLEETIKLAERIGTHSPLIVKMAKAAVNQAYETTLKSGLQFEKAYFYGTFATEDRKEGMTAFVEKRPPNFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4A0</accession>
    <name>A0A835G4A0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) polymerase nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000692">
        <property type="protein sequence ID" value="KAF9405716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="222" mass="24799" checksum="998F458641A57A3C" modified="2021-09-29" version="1">MIVPFTGACPIRQYCPGKPHPTGPSLVAEDKTIELKQSMIALGAYESKSEANRRVEVLGALHLPVQQWIKEQSLKKGLSAYVPHSAIGYICPFGSYRLRVHPRFAKIELCVAPQHIQRSDFFTSLYELLKGHPQVTELRALENAFVPVIKMTFSEIRIKLLFASLDLPKIANKTKPLLANHVRSEPSDGESDDEDLVAPLIPRTFRCLLETPMGTEDIEGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4K6</accession>
    <name>A0A835G4K6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4K6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="94" mass="10385" checksum="0DD9300AF3731DA0" modified="2021-09-29" version="1">MVKEKDPEDIYRKNLDMCITDGIVKGGGGLLLGTLASVLIFKRRWPITTGLGIGMGISFANCHLKMKNSKAINKIKANLVNRKPLALYHETRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G507</accession>
    <name>A0A835G507_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein lava lamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000360">
        <property type="protein sequence ID" value="KAF9408800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A835G507"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2520"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2546"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="748"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="876"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1621"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1879"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2005"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2105"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2332"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2455"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2524"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2546"/>
            <end position="2557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2611" mass="300119" checksum="E44B717109969D39" modified="2021-09-29" version="1" fragment="single">DQSDTADSNIASSEVSSVVGSVKTSKTSQRVSSSSERQIKFERAQKCLENAALVSKRIKEHRKATAELLGRPFEDDDGGDTASELASTVSERTGYSAATDTSTTMSFLASVQPADSSNVTQLLNTIKEKENSLSVMQVKIRAMETTILDLQEMINEKDQIIEAKNKATTLMSDTLSKKEKDSLILLEDTRQQMTKMQENFIAMETEWKEEKQNLLKEIAIKDEKITSLEEANTILETSRFEISVAHSKLAEELEAKNLEILRLQEKIEGLSQITIDEPSPKEKDDVEEEKGSLEIAGMAELTKKIELLEQLNCQIRQTNKELENKLATVNTEPKSPSTAAAGKKGSPLTTRKGGRNTAAKSKSLGVNYHRKTDKKAAKSEIARLEMLVQSLNKDILEKEYAISEKDALITQLQNVPVEKEQKKTVEMVDVGLCTDIPEDNRLSTQGEIEKQDSSVELKSSNEEPSVSELVEKLKAAEEQIVTLNNEIDAANKNMIKVKSNNKLKLKQLQKTIDNFSKVSDTNAEIIKLNEEIHQLSQKVAELEEEKGNLQLHLVDYDSGRLTDSDIYKKMVEMENLAETRLKAISVLETQKFDLVQELHILQQKNDEMEDKLADISQLQSEHVCTEMKSVQMEEQIDELTAAKKELEIVIENLKLDKEHLNDTIKHLQEEKEEVTHKLENYIQENMELTDKLEKLSAEKVSSAESIEIVESLTTQEKLELEEYNKGIVEDKCDDRHEDNVESQNDKNIDSLIEQREELNTKIELFTQERQEVMEKMTKIGSENESLLEKISELNNQCSVLQSNIDILNNEKQELQGLNQELSHQIEELKRERIEIMKETAETAKPVTEDLTDGVPIEAHHDDKSAGDKGTKGAKSVKQLTKEILKLKNVIKEREDEIADCQMKILSMEEQQQKQKELLQTNASYESKIKSLIDENAHLKQDLDVIRKETESKEQVMRLKQSNEELHQELQKVHQEYAVTVGYRDAKINELENVLLEYEKQMFNYGNTLQQKDKEMAEYINQITKLNDVSQKLKSTIELLEEEKAKDQNAELVKALNKQIAAYQKKIADNEEKIKTLEDEKVQLQCLKAELGNKNTTLESELKKLKDSFTEKQSLIKELQTQQQKHAAEMSSIKLQIIEKDEEIHEIKLQLRKESIENEKLRDNIADKEKQVDELTRQIEDTKEKLNNLSSEKNNSSEQFVALETKNKELMEKLKKFAISIKKKSSMYTELETLYEESQKQLSNKNEQLEQLTIQVETLPALQEKLKHAEEEMNRLQSQKVTLEQQRTQDINQLQTEIKALQERLIMSSQEITHLNDSVNVLHKDLHFAREENIHFKAQIDALNNKLVEYEIEQKNNSNLITKISSLEADIAQKQNQIAELLIKVEHHEQQQTQVQFGYDAKVQERDLYIENLETEISKYKNRICRLEESISVMEDGRHSLERKADQLGSQLQEKQKAYTEYTSQEDELVGRLAVLMDHDREMQYKVQHLNEDNQKLRKALSEIQEHYSMVLDKANKLEPVESELSKCQAQLRELEANLKKITHDHQSLIAKKRQEIEELESEFNTQIENAIKEKKILSEKYEKVNERTSQLEAKLNLELKNMLQTQQTNSVSISSNMESQIAELNAKLNQSASTIDQLTSEVDNLRGANEQLYMQLTQKEEQIKELKDNQKLTFEMSIPKTEGMIISSTIEPVSAEDKNIDMSALESQIVSEIDEPLIESKHVPKKVSENIQKQPMGDMVVEEPLIVAKKAYDCYTKDDDENTAAEVDPFNSDEGWGLGECDETSEVTPGFSHLKEQINQLQRENSALKAELEMKEKLDNEIELWKFKFKEANDKLSSMQWGGETKDSQPQEQSHTQLKNEISNLHSQLQHHQTVTQNYEVLKGQLDEMQKSNEELVQTNDTLTEKLQNIEKQYNDLTQSYEKLNNSIEEIKTNYEQEKALLVDRHSSLEEELIRLQQLDSESKTQIASLYSELEKYKSKLLFHKEQDGLNRLQSADSLALAEKCSAMEQHCMQLKHELDEANSKILQLESENHELIQKSKEYQDQINDLNTKMQNLNGENDNLLSTVAELRSSVSSAIDQRGFEIAELWKQHLAQREADFQKIESDLRTQLNASEAKYEQLLENVQSSNQEETSKLIAIEQVTSLQSKLEDKEEHVRNLQVKYAEVMNQLDMLRSEMEDEKVGHENKLLEQQEEYEKMIQEMTVKHHKHNESYDETFKNMQNEIISLKTNNDELNQVIEDLQNKLKESENSVIEATNQLRLKESEIYQKTHDYTITLTQRNEEFENVRKQFIEYEKRVEDLSYEKESELALLRLKMHENDTRYENMRSEAVAEKEKLIEELNAKIVECTNLNKQIVDLNQELESQSAKAAEMQAALENQEIEIVGLNDEITNLQNLIKSSSAKVQKHVSFASDTKPGAEGELSENVLNKDLLDAVPRAELDLALYMLHQRDVRCEELTMELTQLLEERDTLQLRLSDCLRLNEDLKNKFKMAGFDESMNSSQETISELPSFTVEREFVDVHRGQTSRSSSISDPDGEKPKLQAKLTELRSVKHSRDVPIPAGKRATSAGPTVTAARRRQPTPGGPRDSQSTSTVLLNWLRGKSTPKVVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5T4</accession>
    <name>A0A835G5T4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000587">
        <property type="protein sequence ID" value="KAF9406472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5T4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032991960" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="309" mass="33660" checksum="78EE97C98F02B1B1" modified="2021-09-29" version="1">MVSWVAAVLVISAAVVSAYPAKDPVIGKWSEGLRYDYLEDDAGKVHLVDNWMKISDFDRLARYNPDASNRYHLFTRSNPSISQPLVLNNPATVHNSNFNPRRRTIVMMHGFAGSITSGFNTVLLPAFLAAADVNVIILDWSAGSSWGPRAIQAGQAAGRFVNWLNSITGASAGDYHVIGYSVGGHGAGIIARTINGNVGYVTGLDPADRWDTAWLFRPSDGIYTEVMHTNGGDSGWLNPLAHVDFYPNGGRRMPGCMTSLCHHYRSYYYMAESLRTGGFTGRRCDNLNAALAGNCSGSTLRMVTLDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6K2</accession>
    <name>A0A835G6K2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6K2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="20695" checksum="C67C694DCDCEA242" modified="2021-09-29" version="1">MVLPRVLNITQPVRSRHVAAMRSGALVTLVASSLYLTLRYPSSMELLIPLLASAAASGEPYERARSDHDAPFSNIPDSAFTLDEGILDADSASHPTAAPQRVHKKVLNSHEEGVDYYRPRSIYVSSMEQRAERPADAWRCCGTCRRRPGQCLCPLSARSPIVATVCHSCCRRRPHLLPPPPWAGDIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6S0</accession>
    <name>A0A835G6S0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_011554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000353">
        <property type="protein sequence ID" value="KAF9408911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6S0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="13">
        <location>
            <begin position="416"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9408911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="597" mass="65218" checksum="AD90548E2503DAF2" modified="2021-09-29" version="1">MAMNTTAPTSADACLSIVHSLMCHRQGGESEGFSKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKFCQFAFDLKCDSVCVNPYHYERVVSPGIGLTLQSGPSRLVKDEYTAGLSGNGMDMDTGEMVTIQHHATSPRHHHTPMPHHHQQFQTTNIIINQGQRGGMGQGQMSSPRLAAAPTMSPATPQMPSMNRPMSLPSPQQMAMAQQRAVAPKLEPPDTMDARAMWLPKRMNHSAMPVTMSPGATTPLIDGSNSTFFTSETTSNDSSQLTQTLSNSHAAGTVSPGSGEGSQQNGFATDGSPAPQPSPLPHRTQHQQQQGTWTGNNTLTYTQSLAPPPAAPPVPLDAPPHHHYYNGNPGGLLSSQPAPEYWCSVAYFELDTQVGETFKVPSSRPNVTVDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCLSDHSVFVQSYYLDREAGRAPGDAVHKIYPSACLSAAAGIGVDDLRRLCIVRLSFVKGWGPDYPRTSIKETPCWVEVHLHRALQLLDEVLHTMPIDGPRSTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Z2</accession>
    <name>A0A835G6Z2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Z2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="123"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="455" mass="52033" checksum="D71218A9F134DB58" modified="2021-09-29" version="1" fragment="single">ATHVKLIPFWDLSENQISDILNQSDFEDVSDDETYFVNSDLENHHSSSSDEGSNSDTEVVTTGVRSRGVRTRGGVRIRGIRGRRGVRTRGGSTSCLREIIQEGEWNREPSYLPSDVNSDNIFDYFEQYVDDDIIEHIVTKSNQTAIERTGRSLNFTKEECKIYFGITMMMACIPFSQIRLYWNRQYALPIISQAMTRDRYFLLRNSIKVVFDNDITAEMKRDDKLWKVRPIFDRVLQGCRKQLKEHKMSIDEMIIPFTGACPIRQFCPGKPNPTGIKAFVLANPNGLVCDIIIYQGKDTVIAENGSQFHLGEKIVLKLTESLVPGHILYFDRYFTTVRLANELDTRGFKCVGTLMKNRVPVELIDDNVYKNVSFDDDGIPETETNVVVRRPPIVPLPSKAKRKHGIDHLPDMSSVQHRCRNQGCTKKTSVKCIGCNLSLCLTAKRNCFKIFHERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8B1</accession>
    <name>A0A835G8B1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000286">
        <property type="protein sequence ID" value="KAF9409973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8B1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="377" mass="43712" checksum="ADF029AD996F3388" modified="2021-09-29" version="1">MGREKSNKGTMAGSRERLLYERRPDYEYEYEFRRRYEPYDRESNRYRQERRRDLHDRPRRKNGYVYEDIYSDFDEAQGRLSLFRPIRPEYLNLPTTYDIKYNSLPRNYYNYEDRNNRRYKKDHYDFRIENERRTRQSYESYRKAIEARPKETNPKNSLHPTINLTNHSTKTNLNAPTNSSLKQPKNVAVCKPHRVSDKSARYWTTDPPERGRARPKKAEEPKKNVKFSEVSGCNRKMVVDDPICGRKLVPVRELEVSLDQMIQNGYFEKHNIPISRPVGGEVKEEIKGAAGNSLPNGKCLSGTGGKEHQATRKIRHLPQVLAALAVSLAPFSAGLGKGYSSPAIASLQGPGANATRRDFQLTDQQASWLASLSFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8E2</accession>
    <name>A0A835G8E2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pur-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PUR DNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000305">
        <property type="protein sequence ID" value="KAF9409650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8E2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2450.30:FF:000001">
        <property type="entry name" value="Purine-rich element binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.700:FF:000004">
        <property type="entry name" value="Transcriptional activator protein Pur-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611">
        <property type="entry name" value="PUR-TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611:SF0">
        <property type="entry name" value="PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04845">
        <property type="entry name" value="PurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39735" checksum="4CB26FBD73FF2850" modified="2021-09-29" version="1">MEPLSPVEALRMLLVGKFFVLVRCGRDFDECSTRQVFWFFSAVVEKIRLYTVFNWKSETWRADSTANINWCSDRSVVCGEVSVCVKYHGQSMDAGGNNFDSGQQPQEQELATKMLQIQSKRFYLDVKQNRRGRFIKVAEIGADGRRSQIFLAMSTAAEFRDHLSSFSDFYSSLGPPNPDNVPDDGKLKSEMMLKDNRRYYLDLKENSRGRFLRVSQTITRGGPRSQVALPAQGMIEFRDALTDLLDDFGIDDGGFKGELPEGRHLRVDNKNFYFDIGQNNRGIYMKVSEVKSNFRTAITVPEKCWTRFRDILADYCDKMCRAHQPADAHQVTAAPGPGPAGAGRLGTQLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Q9</accession>
    <name>A0A835G8Q9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Q9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="369" mass="39833" checksum="73B7DEB4A6D566A2" modified="2021-09-29" version="1">MSGGRQHQQEQTGARLSPAREPAHAQSLPRAERRARAPPVMLRHGRRGASGHSEDSTEQLICKTPQKKVKKVTKDKSVSSKSVEAGSDEPHRRRLVVFLGLGQVVLGALLVGAGALAVVKGAALSRVGAGLWAGCVAVVAGVVGVLAGINDCYGLNASSSGSPLLTAFLALSLLCLACGNSAAVLAATGLQRDSLRQPTTPASFEDEMEAWTPVLTNIALLIIASAHCLLCIISIYHLSKRVCPCFRPKQAFEHNQFDPAFKPVQQYVVTVDEVKKAHDVERVRNHELCKELEVKLQGDSNKKKEEPEYGSANSKEKLITFLHEKPCLSPSGIIDVTWQYLATPLQVAQPRIYDCRIKIKLSIVGTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8W7</accession>
    <name>A0A835G8W7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ALMS motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000217">
        <property type="protein sequence ID" value="KAF9411668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1799" mass="201171" checksum="1E83A3630CB00349" modified="2021-09-29" version="1">MERDEIEKNDAGSSNDVDSRGAVNSLILDYYKKFGRKRDLEQFFSLSTAQSDIKDTSGLFWRKMKSENDSSDSGGRKSDSSQEVCRISIRCSLPEPTSSQEDDEQKTKTDSPHTESPPIIIEEVPADRKLEWDSLADVGYANESDRKNSASSLSTLERLALKQQYTNNDSKQEIGIPTSHSTPIDENDNKSKIKKGIGKKTKFYKKDVDFVEVNVPHTSDANPPPSINVNLTKHISFNVERDGGVTIDNVKKDVSISSPEKVSVDTSYVGMDKEIQTTLPLNKPEKKEKSSSPNEAPKPVDPYNQKIPVMISLNTLRKRLRKKKARNVRRKLRVRKQKEVNKDETPQEKSGAQLSEAESFEYMPGHVYNQNKLKDNAPILDNSAAGNKSSLESSGLTTDSSKRSKHSLTKDLEQCVELLKHTLQKRYDDGNIKKKLIKDIVERLVNSKYRNDYNSDFLSGISSKRLGMIGNNTTTSTSDANNTEDSTNKKPKKSILRSEKFNANVVASTSQSAPNLFSASIEKVTSNLIKPNTSNTESDVSSKEKTSSDNGFPKTSSEELYLRYLEALRREEAYKRHLKDKEMFLKQKLVKSDTSFKVPVNQEAKMNRRMKDLMKDLTRNNYDDGSGDASKLEGGSSTNLDIDRLSAVRSQRSHSVFTLSSSHSDALKRPNLKKKIQAEREIDEAGPSQGHYCCCPHHYLNAKTGFSDNSVQVNIKNCDAAVGMPCQGKGKDCVIMLGDNKKSNSECPKNTCVAPDSHKGDIKYVCLCGGKQVSSSEVGDNFMIYRCCKLTNRGIQPEDPSRINTAVQCGSCEMKDDKIELLQPPCRLATCTDSSSTDNTSNPRRHSRASQTNMLINMCLGMNNYQSSGSDIKKIRDTTTKSIVCAKKHFVTEATRCLQTEISINPQISDPRLSDINIISNNDCARLISEQRRRVSVYSTESEGVKTFSDVSTNSTSDKFLIQSEGSLCKSDVTSKQNSEDKESRKSSLVGKDYTIPIHGTNMTLTVNLGANNVKNTGPNEAGVVTEKISQADQETLAICEVSKSAQCCLNPECSNSANTNSKTDAAVSTKTSCCLKNISSGSTYNTYPMETVKEKSPFKRSNTDTDNKLSTNTSIQTDPILTKGEEINNNQGTRVDIRSSKFNTFEKISQVERSRNINVAKTKEVRIDSNTTDINKTSRDRSEIRQADFCSLNSKKIDNSRAENSKSNKNESKIDSDKAGYCCNTEKTDDTRSEDTRSSKNESKTDAYKGDCCDSNSKKTDSTRTGSIKGSKNESRNDNSKADYCKCKTDSPKSDNNCFAIEKVSVGVQKDLSTEQTKNVIIETDDIHTKNVSVETECRKEFGSDVCCQTDRLLIEDMEKSSFQEKIDVQANTYKTIDSETKDKKLLESRCQNSDCPNSFNSKGPIIDVIQDITRRYSKKDVLKIKKNKCFSEIITVLNYLLETDDSTDPDRKCSTSTGMKSSSDQGKRSKLSDTCSERMVDKSVQLSCKKSSKESKACTDTSDLPCSSDLPTTSSDSAACKVLNKIKKECEKFHQKVKCKGRKCEVSSSTSINCEKCKKVHHCACRSHKCKRSKAFEKLQKKCIAYNLIIQTSESMLSEETMCENKSRPLKNVVLKVPKNKGKKECCYKGDQESRRTSPQRSPKCSKNRTKSGRRESETSDDFSKRIEMATVREYLEQNRPDFVKNTSQRQDCLKFISERRANERAAKRDLLSLHVEKQPDLTSLTSEELRQLAKDIGLDLRKKRKSPKASVAGQQFDAFDKEEVPFFVSVHHVTSLEPFVLSQHFSCRLWIVVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G912</accession>
    <name>A0A835G912_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LanC-like protein 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G912"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000012">
        <property type="entry name" value="LanC-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="441" mass="49820" checksum="0E89C80D004E1C3D" modified="2021-09-29" version="1">MRRSFEKVSSTVLRTFKNLLTADLLSSVSTFEDNMVRFFTNPYDDFKPGSSTVIDKNEITSQIHEYTNNISKRLHASRKNVDGGLYVGITGVSYMFYHLSKNPLLSDNKSIYIQKSLEYLKPALEASAGDKTSFLLGDAGTYALATVLYKELGDEHSAEMLKVYKSLYSHYMNPKFLKCGGDEFFVGRAGYLAGILWMSRELKTAIFTDEEIYKICDMIVASGREYSTKHQSPCPLMYHYYNTEYLGAAHGISFILQMLLSVPGYLSYNKSAAQDIKTTVEYLASLQTEEGNWPCCMEEIGLSDHKLLHWCHGASGTIYVMAKAYLIYKDQRFFDACVKAGEVVWRKGLLRKGPGICHGVGGNGYVFLLLHRLTGDEKYLHRAKMFADFMTTEEFIRDARLPDNPASLYEGTAGTVCFLADLLVPDNAEFPFQDVFSTYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G950</accession>
    <name>A0A835G950_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000283">
        <property type="protein sequence ID" value="KAF9410011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G950"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="58"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="257"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9410011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="459" mass="51831" checksum="4CC04CEFE4C28CF4" modified="2021-09-29" version="1">MYYNRECPMELDCTSLGTALSRDVVRDTEPFWEIISDEHGIDPTGAYHGDSDLQLERINVYYNEASGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLSTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSRQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEDAEFDEEQEQELDEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9F9</accession>
    <name>A0A835G9F9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010244</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (GTP-bound form) with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Pseudopodium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000247">
        <property type="protein sequence ID" value="KAF9410762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9F9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031260">
        <property type="term" value="C:pseudopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="581" mass="65601" checksum="56E213C3C9B5C4E0" modified="2021-09-29" version="1">MLPSAKHKTTKLIMAGTMFRSLFTNSLTFYKSNTSNLRSLHTATVTYAARKGTRAKARAKKVKVEVTKVGFIPHNQRGKDKNVQSNVSKHLDDTFKPIPKDNVYPLKYYRWIVYTAEDAVKAHQQTHHPSMYNVPNALVSAQIEFNMAAAKKNRFMDSFTRLSLLPNLFPRDEERTIMAFCKGSELIKEATDAGATIAGGTDLIKKIQEGQIKLSDYDYVLAHPNILTDLVPIRGLMKRRFPNLRAGTLDNKLGELVKKFSGGVQYRVLKDEHQENYGFVEVPIGRLNMDPKLVAENLEALLKDLQSARPKRDGLFITRPVLEPTVVSPPSPEKLKIDPFVYVDKTLTKEVQDDSDDEEAVAATANMWIRTVVLIGDSGVGKSSLLSRFTRNEFNLESKSTIGVEFATRSIEVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLSYENVERWLRELRDHADQNILIMLVGNKSDLRHLRSIPTEEAKAFAERNGLSFIETSALDSTNVEPAFQNILTEIYRIVSQKQMRDPPEGDVIRPDAEPTDVRPSHTDNNVQFSSSEPEREMRLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAA9</accession>
    <name>A0A835GAA9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000288">
        <property type="protein sequence ID" value="KAF9409936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAA9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="173" mass="19593" checksum="90DBDF72A7BE9822" modified="2021-09-29" version="1">METSSNQQLTFIYLPILKKWTTACRLFELKTLFYFQHFNGQNIRSVKRNISGLKTLMSRSKIDWVVIILTECWISNNQFIPILDGYLSAFTTNNKTQNEGKSLASNVSRSYSPCINNLTSFQPNLSSLVLLPTDAHEIATIIAGLKPSSSLRCDDIPSNGQAQKYKALKKYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAG7</accession>
    <name>A0A835GAG7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000241">
        <property type="protein sequence ID" value="KAF9410910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAG7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="249"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="548"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="696" mass="79350" checksum="A7F8F9F999FCDA7C" modified="2021-09-29" version="1">MGSYSKKSSAEWIIDQLNVENAKLLAFFLVIGFIGYHGVLHLKYGSDSCTWLLTAGRYKGDHEWQPYGCMLHKYSKTDARRCFRYLAFWGKYNSFAFIGDSRLEQLYEYFISVVRTRLDLDSPYSTVEHRMPNYTYVDNKLRLSVTFVYSDDVSKTMVDQFRTWQRSDQPPSVIIASTGLQLLKTRNTTDLVLEEYKRNLTHLVQAIDSLAARKTQVLWKLIEGVDVNKLQNDYKRINNNDIDSYNRAAVEILTHSAAKIWNGVLWVVRSAWGAYESARSHLQGYTPVSRAAPSSDADASGSSPSLLAAMARLGLIMSYFYLCDRTNFFMKENKYYSEWSFWLPVGYVFALGLFFTEDSKSNTRTKWKGWMQLVILVYQVTGASKVLPIYMLVRTLVSAYLFLTGYGHFYYTWKTGDTGLVRYLRVIFRLNFLTVVLCLTMNRPYQFYSFVPLVSFWYTLMFVIFALPPHITPSSSHTVESRPYQYLYITIKVIGLLVIVTVLYMSEVFFQKIFVTRPWKALFVNSDDDIHQWWLQWKQDRAWGGGATALALLGLAAYAAFALLCSNASDCDEIQSYVSFLPVLSYAWLRNARGALRARHSALFAWVGRVSLELAAGGAHALGAADRAGRLVLLPGAPTLSVLVAAYVFLCAAHDLRRLTAQVAPRAVPDDWRRALRNVAIFLAVLVPIGIHDGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAN1</accession>
    <name>A0A835GAN1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000224">
        <property type="protein sequence ID" value="KAF9411455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAN1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="17632" checksum="6EB8A5121E42993A" modified="2021-09-29" version="1">MNVKVAEMAVAKKPVAKKAQLHQKSGKKGVKGGKIRGKGIKRKINLKFMIDCTHPAEDSILDVGNFEKYLKERVKVEGKTNNLGNHVVIARDKTKISINADIPFSKRYLKYLTKRYLKKNNLRDWLRVVASAHDSYELRYFNINADSDNEDNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAW1</accession>
    <name>A0A835GAW1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAW1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="335"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="51715" checksum="10329AD97C7B5A4F" modified="2021-09-29" version="1">MVRNTSNLVSFRRRDEKPPQNEDGVSSNKACKAYNSVLELVGNTPLVKLNRLPLEHGVKCEVYAKCEFINPGGSIKDRIALAMMQDARKDGVVHDQTEFVEVTSGNTGIGIALNATLMGNKCIIVTQDKNSSEKVNTMRLLGAEFDNEINPRAHYENTGEEIVAALGSVDVLVLGAGSGGTLSGVGSKLKEVNPDCKLVAAEPDGSVMINKDGNPHPFLVEGIGGSEAPIILDKSLVDHVEVVTDKESFLMARELSKKEGLLCGGSSGAAVCAAFKAAKSLNIGHGKRVVVILPDGIRNYMSKFVSDQWMEAHRFLEPPQHTMKWWTKPVSDLNLNREYPKMTSKSTCHQVLEAMNETNVNIAVIVDDNGHYIGAVSKDSLRNRATNPTKLPGQVSEEYDFQDVVTDHLDKHVYTLADNIPEDTTIGLLSRVLDITPYVVIVTKDSNNSAFCTPSKVVTGDDVLDYIFESSKTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBS8</accession>
    <name>A0A835GBS8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_000924</name>
        <name evidence="12" type="ORF">HW555_009808</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000227">
        <property type="protein sequence ID" value="KAF9411361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000363">
        <property type="protein sequence ID" value="KAH9638998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBS8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="121"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9638998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="295" mass="33013" checksum="B6EDFD4F518AAD92" modified="2021-09-29" version="1">MDEIEKEKIAALPSQLLVTTICHPMEYAKVLIQLGYEPLPPRRSTTLFGRPAMILPNVFQYIKFIKTSDGFFGCYRGLSARVLGLIASSQLTSKVIFAMGIDLPEINDPPNIVTDEEPKVEDYIKLGRRDMIMHTASVIVSYPFHVVSVRMMASFIGKEEDYSSLIGAIASIYRDDGIRGFFHGIIPKLLGDLTCVAVTGVLAYYVNKYLVKTKDLRYYTVPLLTFVTSTITYPLVVVSTCMAVAGCSLSAGNPPNMPKYPSWQACWRDLLRNKQHKRGSSLIFRYYIAPIAAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBX9</accession>
    <name>A0A835GBX9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pheromone binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBX9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006072">
        <property type="entry name" value="Odorant/phero-bd_Lep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00484">
        <property type="entry name" value="PBPGOBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42637" checksum="CC227838DAEEDA55" modified="2021-09-29" version="1">MLIGLLMYEAGSVLGKNEDSVLRVISSSIGDTVLECQSEMDFKDEVIHNFMNFWNRTNSLGTKDLGCALVCVFEKNAFLSPDGNTVLSNNVRQFLRASGADELMSLRTLDLFEMCKDEVKQVINRCDNALELGKCFRYGIFQLHWNPEPHYWTRKEEPSKIPKQVTELQKAPRPLSRKPVPAWRRRTDLRRIVGYRHAYINWVNLVEMGSHNVFVALVLLAVVGMRVAEPSKDAMKYITSGFVKVLEECKQELNMNDHIIADLFHFWKLEYALLSRDTGCVIICMSKKLDLLDVNGRMHHGNAQEFAKRHGAGDDVASKIVQIIHDCEKKHERDDDECLRVLEVAKCFRTGIHDLDWQPKVEVIVSEVLTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCG8</accession>
    <name>A0A835GCG8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein complementing XP-G cells</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCG8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="793"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="537"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1121"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9413220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128641" checksum="DD928FFCE9B376D7" modified="2021-09-29" version="1">MGVTGLWRLIEPAGKPVPVETLENKVLAVDISIWLHQMVKGYQDAKGAPLPNAHLMGLFQRLCKLLYFRIKPVFVFDGAFPELKKETIAKRQDSKAKYNSESERIKRELALLLSKKTAVSSILGKEITPPKSGQTSIDKDDIFKLPALPQKEDESESESEDEQNSSGSSIDVHSIDIQSETFKNLGVKEKYDVLIELKETRKMNSWGRLHELPKESNSFSDFQMQRLLKRRKVQECLEETEKEMGDTGMSLNDLESLLNEEGIDTKIDTLPTRRIASNVSTRFLLIRDVKKALAAAKQRNQAENNPTTSKIEEIIEINDNAKATTSEDTEITETNDEKPKKVDELEDDLQRAIQMSLECVDDPSSSQPNQDTSIVSKTDDSWTSCMTDTDYSDTDSEEGDGCEQPDMSSAKAYIMQYSDFTHQAIDKIVTNRNKGKKNKKVPKVDEILDEINNEKSVIVDKVELSSGDEDDEGAVLVSSGEENNKTSATTECSSSSDRETDKCLDSTQASVICVGNPVQEVIDLDSSVEEIESIKSALPSGNIKHESTSSDEMEEVSTNKNKSESESSDSDFEEVPEENTEVKRPVVELTLNMGNAPDDDIFADIFEKADHPSGDKNEAIKETKAEFAEVFEKADNSVGDKNEAIKETRANNEVLTPISGLVDKVFKVPEVPVLKTSYKMTPPTILNPDIDGKCPAKPNEANADKADDTAIQENVVPSKSSETTNLIVAPEKHSQLIKTSNPPKQTLTTEQLTSMVEDIQNEEQDLMQEKGRLDRIGRNITEQMTKEAQELLQIFGIPYIVAPMEAEAQCAFLESVNLTDGTITDDSDIWLFGGRTVYKNFFNQKKHVLQFLAERIEKSFNLNREQLILLALLVGSDYTTGVSGVGPVTALEILASFPFNKRQLFSEESKQARYAQMVVQAYLEPNIEKSKDKFTWGELDITILRDYTKAKFGWSQNKLDEIIKPVLKRMQDRKTQRSVQDFFKRKVEFQSLEEQMSKRVKAAVQKMGPEGPLVLETEKPAEIDKPAPKRKVTKKDAPSNKNKAGPSAAKQRKNSEETVLLNQGVKVVTQIKDGKSEFEIKIPKTDRYQELIPQREKYKRTLLENKLKAIEIFRKTKLDQKRKQFKRKALQPKEKAELSESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCQ3</accession>
    <name>A0A835GCQ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-27A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_015469</name>
        <name evidence="6" type="ORF">HW555_009633</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000219">
        <property type="protein sequence ID" value="KAF9411630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000548">
        <property type="protein sequence ID" value="KAH9635469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCQ3"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001149">
        <property type="entry name" value="Rab40, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9635469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24331" checksum="674B343CB00B926A" modified="2021-09-29" version="1">MDYDYLIKLLCVGDSGVGKTSFLYKYTDGVFHTQFISTVGIDFREKSVIYQQNGRQHRIHLQLWDTAGQERFRSLTTAFYRDAMGFLLLFDLTNEASFLEVRNWIEQLKTHSLSDDPDIVLCGHKCDLQEKRLVNQNRAREFAKNYNLPYLETSAKSGQNIDRAIEILLDRIMNRMESSVEYAMLCASGRRRQSLQKLQANKDKKFCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD77</accession>
    <name>A0A835GD77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000158">
        <property type="protein sequence ID" value="KAF9413479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF23">
        <property type="entry name" value="BCDNA.GH07066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="713" mass="79779" checksum="B0EE422875B3C900" modified="2021-09-29" version="1">MESWQDHKVRDTGAVINILDIGRQNFANGGVVSRYLCDLAQCCNLCAYDYKDIVPNVVKDESVEQAIEEATQEELAKAKDNGQSGAQYATIRKRVEARALKVVQDISSAMSNNVLKFVAWVCHKAVRRVAGGGCGTRVAGVERLRRANAAGLPLVFVPLHRSHFDYILMTFTLYLTGLRPPLVAAGDNMRIPFFGWFLRGCGAFYIRRRVEGSEYHGDPTYKSALRAYILNSLSAGNNLEFFIEGGRTRTGKPQTPKAGILSVIMDAYLDGTIDDALLVPATLNYDKLVDGNFVREQLGMPKQMETFWSALRGIWRTLNTNHGSIRVDFNQPISLKELVTSFQKYQHYKAPIETCLTPPNNNLAVNLDRQILYNHSHSSLYGADVSTDHKMMVEAIGRHLVYGNYPMIALITVFVWLLKLLSVCRRGAGDGVDVYERGGLEMLGRGLVRRDGDMIRPGTSIAAQLELAYYANTVVAHYAAPAIVATALESLICATSSQEFRHSDLVSASLQLCEVLSHEFIICAPCQRIQDRILDVIDSLESQQLIIKDKSTVVLEEQQWSRRMARRLEGDDEDDRPDPTERVTYTVSNKPEAIAERRRLLLTIRPLLEAYSVTCRHLQAGTMKDVVKNSLDSLTEDFTQNKMLFGEAVSTDAIRNCLRLLRQWGVIHVYTEGKARAVRLAEPYTSAPALEDVCHNIHKFNMNSPLLLEPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD83</accession>
    <name>A0A835GD83_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000160">
        <property type="protein sequence ID" value="KAF9413419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD83"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF152">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="336" mass="38537" checksum="85A6FB9FB94AC864" modified="2021-09-29" version="1">MDRDRSKDASEGIAPMGIQALNETVLSNQPESRYECPVCLNWLRDPVITTCGHKFCKSCITSWLQNSGHCPIDNINLSMKVDIFPDNYTKREIQEQRMNCPFSTKGCTVKVTPLDLDAHIASCEFNRPETSTQPEIRVPCSFQTVGCKETFDSQEDMNHHAETDVQKHMSLLMNAYSEMKINNDMSNARIDAKEQEAMTLWEAPDKDGNQAASAPLNNTSALIRALYERVVVLEQRNREQDIVIANMSKQLSAFAVAKMKQNNDMFLRYCMGNYVWRIDNFKARLDAMLRDHYKMLYSPGFYTSPNGYRFCVRLNISPQNPHCFASPRSLDENRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDG4</accession>
    <name>A0A835GDG4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="14">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_008927</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="JACKWZ010000183">
        <property type="protein sequence ID" value="KAF9412615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="952"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="996"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1181"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="19">
        <location>
            <begin position="310"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="622"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="19">
        <location>
            <begin position="954"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="1274"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="886"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="900"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9412615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1539" mass="172238" checksum="07F4CA522644AD30" modified="2021-09-29" version="1">MTYNSTLDNFCGSTFWDSNLTWFTDNPEFTPCFEKTVLVWIPCAYMWLAALVDIYHIVSSKEGNIPWNKLNISKLVIALSLVVLQILNLILITYASSKEENKIYDADFYDPVVKLLTLMLCITLICYNRKYGVMTSGVLFIFWLLLILAGLPRLRTEIVNYDPNNSGYARYTFASYIVYYTLILIMFILSCFADLPPKDTPYTYDKVQSPEKRSAVPSELTFSWFDPLVLTGFRRTLKEEDLWPLNPELTSKEVVPRFEKQWQKASQKRAKTANTNASTTDATTPINQKQSTKPISILPVLCLTFGYHFLFAVFLKVIHDVLIFVSPQLLKLIIGFIEGDDPVWKGYLYAVSMFLCCVIQSLFLGQYFINLSVISVQIKNALCSVVYKKALSLSNAARKECTTGEIVNLLSTDVDKVCNLTFINMIWSAPLQISLALYFLWGVLGPSVMAGLAVIIILMPFNGVLAGFQEKMQAKLMLYKDQRIKLMSEVLNGIKVLKMYAWEESFENQILRIRNKELAVLKRMAILTSFMIFIWICTPFLVSLMSFTCFVLVNDTEVLDSKRAFVALSLFNILRFPMFMLPNVISDIIQTAVSIKRLNKFLNSEELDINAIEHNPDEKHQIVIENGHFTWGDHESKAVLKNINLQIPRGSLVAVVGGVGSGKTSLLSALLGDMDKLSGRVNIKGNIAYVSQQAWIQNATLQNNILFDQPFDKNKYNKVVEACALATDLEILAGGDQTEIGEKGINLSGGQKQRVSLARAVYCDADNYFLDDPLSAVDSHVGKHIFDKVLGPSGLLKNKTRVWVTHNVSYLAQTDLVVVLRDGEVSEAGSYQQLLDKKGAFAEFLLHHLSIAETSSATQDLEGIKNDLENKLGSDFQRKLQLARSMSSRSAASETEVLETGDHSQETQAKDKDGTPEEEQAFDQLIEDEKTETGKVKLEVYMHYLSKIGIKSAIATVIMYIVLHSLQISVNFWLAIWSNDDKMLVNGTVDTQRRDMYLGVYGGLGFGQALASLFTDLMPFLACWRAAKILHAVMLNNVLKSPLQFFEVTPVGRLLSRFSKDVETVDNSLSWEISNVLSGIFEVIGTVFVISYSTPMFMIVILPIAAMYYMIQRFYVPTTRQLMRIESVARSPAYSHFNESILGATIIRAFGVKDRFVKESQQKVDYYQSVHYLSKVSDRWLAIRLETVGGLIIFFAALFAVMGRETISPGLAGLSVSYTLEITQTLSWLVQMMSGLETDIVAVERMKEYAEIKQEAAWNVANGPPAEWPATGALQLERLTLAYRAGAEPALRDVTCAVAPRDKLGIVGRTGAGKSTLTLGLFRIVEAVGGRILIDGLDIAAMGLHQLRSRITIIPQDPVLFSGTLRMNLDPFEAFSDEDIWRALEYAHLKPFVQGLPAGLRHEVAEGGENLSVGQRQLVCLARALLRKTPLLVLDEATAAVDLETDELIQKTIRSEFASCTVLTIAHRLNTIMDSTKVMVLDKGQLVEFAPPEQLLQDKNSLFYSMAKDAGLLPVISGANLYRFNSLLQASHKVKEVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDK8</accession>
    <name>A0A835GDK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDK8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="279"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="489" mass="56844" checksum="625AF3F536D5F184" modified="2021-09-29" version="1">MNKTIKSGVRELLFRMISKFEEKQQEKDVEFKRKQDCLRVVLNFLGNLKDVAGVDEIVKTIENLSNLEQKDRIRTQNQYLDDIASITEVSVTTLKRIKKEGSVNEGVWNTPGKKRPHKPTVSDLDSFDIDAIRNKINEFYIVRKQVPTLRTLLVELRESIGFNGCRETLRRLLLSNGYEFKKNKNERSLLIERYDISAWRHRFLRTMALKRREGKSIIYLDETYIHKNYKPKKSWQGPSTSGAIENVSTGKRYIIVHAGSEKGPVPNSLLVFSSKSKMADYHHDMNAVNFNKWLREKLIPNLNEPSVIVMDNASYHSIIVNKAPTSQNRKDDIREWLTLNNIPFEDYHTKAELLCFVKRNIPEPVYEADELLKENGHEVLRLPPYHCDLNAIELIWSLAKRKVASKNLGLDAAEFERIIKDSFESITSEEWKKMTDHVIHVENKYKERDRITENNLESFIINVGNSDSSDSNESFQIEVLDSDFDYGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDV0</accession>
    <name>A0A835GDV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000109">
        <property type="protein sequence ID" value="KAF9415527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="2">
        <location>
            <begin position="458"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="799"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="961" mass="108285" checksum="E911CFC400C887DE" modified="2021-09-29" version="1">MATRANVAKTTHKMPVLVTCYRCKKSVDEKKTALCSICKNRMEPDCDGYPLQTYRLKSQESKTKWRCSKCTKKTVPKNVPSPDDNISNNVTVRKKPAYSINHLHTDIYKNKRKLLSPNQDSHILSDYDTSCETDTNTPKRLLTDSLDGSSTIKSPILYYEMQDTIAQLTTKLECAENALECKTLQNNELNKQVEELTKEIKLLKTMTEAGFVKAQSDNLPKIDAFMMTAYFASNPDFTSAEIRGVKAARSTRESYGDSAVGYVQVKRDGDICVVKARITPEHNVRQKCYAVICTCNETEETILSVQCEDCAAHLGGCKHAIAFLAWLHRRSEDPSTTSIECYWKKSKLSSIGTSKKFIKAKEMYKTPKHELVPTSLNTESFLTVVKNNCTLVGDTKNHLMKFYRAPSTVEKLSIHHLLSTSKATNPLDFIEYCKLIMTADACKGAAIATLEQNDCPLWHELRYGRITASKAYDAAHCNTLDGTLTETILGASKLRDTEAMERGRLLESQVLKEVEKICKIKISKCGLKLNSTHPIMGASPDGENSVYSIEIKCPTSEKAMGRYVSSGNKVTAKYMAQVQLQMHFSNKAKALFCVADKDFEKTKKISILEVNYDQQLCENLLEKCDIFWNKAIFPKLNIFTSFLVLGVDFDTEGGRIRVHLLASSKHDKSLKPLSAITALLGVALPPYPSEIKLIKPSGVHEIKYFKVLHFLYCDQFGLILTCTALSHAMSSQYEKWKALPEDHHIQYGKYCILVDHRHLCGNPIVNNKNNRQSFTSQDIFSTPTSGRLLDVEDPTETTYRHLHKTIATLQKELTCAEQEIKTLNAQIQVLEQSLKNKQEQQQLTIKTKKPIQASLYDATCKNTIRVFGAQQCVGLAAALTRSRETTRYVKYDVRGETMPNALSDTIVKKCFSTKLCNDDKIIICLGENDYDMKHVLSQLKIFLQTYCSNNNTILGSKFVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEB3</accession>
    <name>A0A835GEB3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endophilin-A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SH3 domain-containing GRB2-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_008422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the endophilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000164">
        <property type="protein sequence ID" value="KAF9413306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEB3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07592">
        <property type="entry name" value="BAR_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="13">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="421" mass="47417" checksum="D44878E71A3F168A" modified="2021-09-29" version="1">MAFAGLKKQINKANQYVTEKMGGAEGTKLDLDFVEMERKTDVTCELVEELQTKTKEFLQPNPTARAKMAAVKGISKLSGQAKSNTYPQPEGVLGDCMLLYGKKLGEDTVFSNCLIEMGEALKQMADVKYSLDDNIKQNFLEPLHHLQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRQAEEKFAESLQLAQIGMFNLLDNDVEQVAQLTFFAESLLEYHQQCTEILKGLVSTLMEKKEEAVNRPKMEFVPKTLADLHIEGIHDLNNGRRYGSTQSLSRPRQHIPPSSSVGDLSTTDPFKAWEAPSPVRTQVRPAPGFKPHPAPRNQFNGRDPWTASPLPSPVKSPARTPVVANKTPCCTALYDFEPENQGELGFKENDVITLINKVDDNWFEGSVHGKTGYFPISYVQVTVPLPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEJ3</accession>
    <name>A0A835GEJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5 11">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_008631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5 11"/>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEJ3"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="13">
        <location>
            <begin position="60"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="513" mass="56940" checksum="04B49C0E37251D4B" modified="2021-09-29" version="1">MVKTCLNSLPPKFSRFCSYRFVSPVHTAYGKINSQKSFLKRNLHTTSIMSNSILNGNLWDTDPELYAIIKNEKERQRAGLEMIASENFTSIPVLQCLSTCLHNKYSEGMPNQRYYGGNEYIDEIELLAQKRSLEAYRLNAEEWGVNVQPYSGSPANFAVYTGVVEPHGRIMGLDLPDGGHLTHGFFTATKKISATSIFFESMPYKVDPKTGFIDYDKLAETARLFKPRLIIAGISCYSRCLDYKRFRQIADENGAYLMADMAHISGLVAAGVIPSPFEYCDIVTTTTHKTLRGPRAGVIFYRKGVRSVKANGQKVMYDLESKINQSVFPGLQGGPHNHAIAAIATAMKQATTSEFVEYQKQVVKNAQRLCKGLMARGYEIATGGTEVHLILVDMRSAGLTGAPAERILELCSIACNKNTVPGDKSALHPSGIRLGTPALTTRGMKEADIDRVVDYIDKALKLAQEITKVSGPKVADFNKTIEESADFKAKIKNLKEEIENYSRSFPLPGFETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF94</accession>
    <name>A0A835GF94_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000154">
        <property type="protein sequence ID" value="KAF9413589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF94"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF309">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="523" mass="57809" checksum="2C0023666F01C087" modified="2021-09-29" version="1">MKASEHVMIAGTAHQPVFGFIYNDFLDELGVGTAAVTVVFGVFQVTLAVAGFSANIALKKLSLRQVGLIGACIYTLASFLAIFAVSTTQLILTNGLLHGLGMGLLIPVSYTSFNSYFTKKKVLYLSLCKASIGMITMFYPLFIKFTMTEYGFRGTLAILCGISAHSIFGALVMHPVKWHLVKQPKPCEKIVLIPPTPAKEDNKDNKFDFTKTLPRIDSSENARSVENLYRINRLENTQKGAELLFVSKLSDSRRLSIPVVLIPADGRIDSSFDTSDHVYRENLFKAASVSSLGNFGNIAAEPMPIIKNKEGKWQTISEFLDLSLLKDLVYVNIIFGLALTFFSDLTFFTLEPLFLDKKHLSKPEIATIIAVGGATDMSARLFLGVAGQFFRMNSRYMFFCGALFTAIFRFVFIHFTTYVPLLILTGVLGSLRSLVHIAQPIVLAEYVPIERYPPAYGLYMLLAGAISLSVGPMIGFVRDYTGSYAIAFNMLTVCNLLCVLPWAVEGVIKYRKNRNTANNPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG21</accession>
    <name>A0A835GG21_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG21"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="522" mass="60529" checksum="9C5EC09B2F755258" modified="2021-09-29" version="1" fragment="single">MPRYKQPKKLETLALSGLGDWIAEQAKQQMLPIIMLSQRDTNEAQSALTRNIVKIREYLDINVPWMLHDLLVNDTIRALSELLEETKQSLGFRRNMGKFVSQMNVIIRMAEVLFTKNLTIVSIDTIPKMLRSVFYSKLYMLNGLVSLNLGSLSGGWKTADMEDAIIKSLKELHRLKCLTMNYDCTNNILQCIVDNCHLLEKLDVSCSKCVTNDSVDIVAKIKNLRSIQLYRTFVTMEGFIKLLLKCKNIEDIGRCDEIGKILEHIDLNYSVGMIFHLKTYVSRYATNNQLQLAVQMCPYIRSMTVFHNTLQSDLMVLIGLQDLRELKLLSCDFYADQIKQVLQVKGCNLVHLHLEHVDQIDLNALMYISQMCPFLESLTFYNCTLIQHTSLFTKKLEIDPFRNLKKITFISTCTEEQLLFILTNCLNVQFIHIGTAIQLTDDVMFKILDKNPLIYLKELRIMQSDYLSMISVDRIIQSCMNLEILVELESWSLLTENDREHIRNYIKINNYNIDTAPIRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG79</accession>
    <name>A0A835GG79_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000109">
        <property type="protein sequence ID" value="KAF9415532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG79"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="18151" checksum="73EDBF03AD61D5E0" modified="2021-09-29" version="1">MPDSNMMSAIYPSTGILRLKKKEDQDDLVVHSPEDISDHMVPASVQMGHTSDQTDLKIFNGSMTIKGSLMFVGLDGNNKDQAGSSRDPHGVDLDLDGVVLDLDGDIKDHLGVKAKDRQIIMGHLGLDLALMVGLKTSMGPIMNNSDVHGFGSDVVLLRDRTGPWGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGD8</accession>
    <name>A0A835GGD8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000124">
        <property type="protein sequence ID" value="KAF9414802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGD8"/>
    <dbReference type="OrthoDB" id="6367911at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="55246" checksum="8D108E3DFEBD817B" modified="2021-09-29" version="1">MAPHRQPSSLFQICVKSSISLINASCYSIEKSYPEHKFPNCEQEIKELKLQLMKLLPARLFDVLCSQRTCCVYRGDPRVQLLALTHPNISIFRKCDTDNGIPLSFWLSTLSTLKRLVVLDLKFICTDEILEVVGQNCLLLEEINIVSRVDICKSLFNASVLIRNVSDAGLSFVTNLKHLRILSMDPPRNERANRIGRCVSQAGIIMCVTKLPYLEELRIESCDIGSTLISSTIDIGPLSLRKINCHFASADGVRKLLKICPFLRELSITHLSEYSKDSILEQIRISEARLYRLDLSFFSYSESMQQLLTVKGRYLTHFSLWEIDHSMTLDAVISLGKCCPNLNTLCLMTQSNCLVIPKYFQRPKKIFSELRSLTLGNDHFSLRDILTFFLECTDSMQKLILKYQRRSMIDDIILQLLEKGYLRNLNYLWLDCTLVVTTKVAKKIIQMCDKLQIFTVDYSVEMVDIIRYINDNNLDLKLGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGR4</accession>
    <name>A0A835GGR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026164">
        <property type="entry name" value="Int_cplx_su10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21045">
        <property type="entry name" value="INT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02106">
        <property type="entry name" value="INTSUBUNIT10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="467" mass="53074" checksum="F2B2E9CC91CC2B8F" modified="2021-09-29" version="1">MPAIDSALSDEDYIISKAKDAQKYNIHSAKAWMLTAKTLFPTNFKIQFEAYLMEKQSGNVQEAAECFSSLMKSRQNLPSLLPEISAIANALRSSEGSFLSQMFDNICPDIQLTILKTSVENSDDTMEHCRLLVLLLKKFPQLGVDSLVKTLINAEKFFYDNRYARLLVVETLPLLSSLESPRLLQRLVIKAIDFYNSYVYDENEHDITDPWQRLFGVLDLMGRQLGWDSFFVNYSNSLNKETYFQKLLSLRNSEDCRQLLYCGTTFFLRSLYEHKSLKGNHILVEALSDPEVAPSKRRKGDLEVTGISSHQFQAAANCWELLHSNDLISREFTKLANQLQTKPWAEGFADEFALYRGKYEEAMPQATITNLTASIVRVSINYFQKNYTACVESILAALPQLPNVEGILEPELIVGGQRRIGTRGADKGVKEDFKQAMKAQVARSNESVLNLMIHFITSERAFFLQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIA6</accession>
    <name>A0A835GIA6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rab5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIA6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11630" checksum="1FA630C451B200F6" modified="2021-09-29" version="1">MFQDTFGRAKNWVKELQRQASPSIVIALAGNKSDLAAKRMVEFEEAQAYADENGLLFMETSAKTAMNVNDIFLAIANKLPKSEGAGSAGAGGARRLGDAEQARSSSCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJT0</accession>
    <name>A0A835GJT0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UPAR/Ly6 domain-containing protein qvr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein quiver</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein sleepless</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_006122</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K(+) current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections. Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane raft</location>
            <topology evidence="14">Lipid-anchor</topology>
            <topology evidence="14">GPI-anchor</topology>
            <orientation evidence="14">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quiver family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJT0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23595">
        <property type="entry name" value="TFP_LU_ECD_Qvr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF31">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9416547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13502" checksum="EB6F3C6E7DBD7B74" modified="2021-09-29" version="1">MNNYSVARTIYCYECDSWTDPRCKDPFNYTALPRDQPPLQTCNGCCVKMVRYSKSPYEVVRRTCTSQLQINLFMVDHVCMMESTGTGHMCFCEEDMCNGAQTPVAALALVATLVACACLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJT2</accession>
    <name>A0A835GJT2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJT2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18932" checksum="0BAA7DA7C5F7A6EA" modified="2021-09-29" version="1">MLKMDEQFQLLFEKMKIEMQNQAVSISNTIMDRIDEKLKPVLEENKKLILKVENLEKKIEFLERDKKGNNIIIYGLKEGEKSTRELIENAKNKFQKELNLVLEDYDINKIHPFGKPNKDDKPRPPKKQQTASFSRNNRTNAFDVMRNRSNSLTTYLTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJT9</accession>
    <name>A0A835GJT9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJT9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31299" checksum="346274D5FAFAEC71" modified="2021-09-29" version="1">MSEEMFYRRQVSRQHLEVLAQYMERYPPLALASARSREGHIQSKRMWEKIARTLNRIDENVSKSGKCWARYWIDLKFKIRRKYAVIQKCLSEGTHCAVHLNPLEERIIKILTDEEGNLLPTASVYHQMKSYHPLHYPLKGTAKTNGLDIKESINTKIDDSGGLDTADDQSQDDYLVTSSPITEHIDLPPSDIKPNISIMKQDTDPIQITEEKKSVEELRRELVEFELKKQKELFEMEKKFKREKHEMEMSILRIKKQLMVKELKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK67</accession>
    <name>A0A835GK67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK67"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000712">
        <property type="entry name" value="Drumstick, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="11380" checksum="F8A025314330D161" modified="2021-09-29" version="1">MFAVMQIDEDHTRDFRRKLRPKCEFVCKYCQRRFTKSYNLMIHERTHKSPELSFSCEVCGKSFKRQDNLRQHSPRLAIESPVRCDKVVVDIVNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL88</accession>
    <name>A0A835GL88_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL88"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="62"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="677" mass="74259" checksum="401A41031E59C201" modified="2021-09-29" version="1">MSPRHHKNTSNDPKYQNTVIVPSKVRSKGSSSSKRDDFEGFEETEITAQISVPAEGGWGWVVVLASFLTIFIFDGIYFTFGSMLKDMTEDLGVDQSLVALINSVAVALYFIGGPLVSALINRFGFRAVAMTGSITSSMALLGTYFAADYITILCIYGVIGGIGACLCSMPSGLVVGFYFERLRSVAMAISSTGSSVGIMVLFSINTYIVNLAGWRVLMLFHSGLVATTYFFTMSFRPLLSLTVTTSPITATTSAERTRTVTYLPSLSAIKKSPSKTKREEILPSAAERLFKAVPSPHFPTAAAVIRESEVVSPTQQTRPGQIEQPGTSTAAVPSRLIVTAQGPQSGISKKQLKQVQSLISKSKTSVPEKEDTVKEKVEIVLEKEIPQKWWQKLFRWEKHIAEARPMYRDDAFYEGPLGKLSAYQKSKMEVAPEDRTGLEYQMAVTRAVTAADLGEKRGVFTSAVRRVLVTMMDPHLLKRVSFQLLCSSGFFTYLGFLVPYVYLPDRMMEAGIDPTHCSLFISVMGFSNACGRLVIGTMAMKCNPLKLYAAVCIISGCAVTAFNFSFNLYYQYVICVMFGFHIASLSSMRSIVIVQMFGLDMLTNATGVMIMFQGVGSLISTPLSSVLKNQFGYDVSFYVAGVFVCMSGIVLIPASRINKIENEKIKEKENAGETKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLK3</accession>
    <name>A0A835GLK3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004692</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLK3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="512" mass="58117" checksum="85E62BA13F77771E" modified="2021-09-29" version="1">MWLLIVILVTCLFYYSRHRLSYFSSRGVRTLPPVPFLGNLTAVTLGRENFVEAIAAGYNAFKDQRYFGLYQYLVPTLIPRDPELIRQIMVRDFNSFIDRGVHIDADCDPLFGRNLIMLTGTKWRSMRASLSPAFSGARCRSMVPLMTESACAVLNYLQEKITGEQVIDVNTITMSYVNDVIASCAFGFASDSLKDPGNCIFRLGKKAVIQDTTQVMKFFGYENMKSIMKFLGVKLIPTQDAEQFSQLFKSALKARRENLVKPRPDFIQVLVDAANGKLKADGESDGNNNESAKTAEKFTDDDLVAQAVLFYIAGYDTTANLIYYFLYEMAINPTVQEKLHEELDTLPSEDEIPDMYEAIQDMEYLEMCVNEVLRLWPLVGSADRRSVATYDFGPTHPGSKDRLIAPAGIHVWLPIYSIHRDEKFWPNPDACIPERFSKERKAEIVPYTYMPFGNGPRHCIGSRFAVLAAKVFLVKFLKHYKTKAIRPSSRLSPIAFILRPKDGYQLIVAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLX0</accession>
    <name>A0A835GLX0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Agrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLX0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000040">
        <property type="entry name" value="Agrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000067">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000134">
        <property type="entry name" value="Transmembrane agrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000024">
        <property type="entry name" value="Transmembrane agrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="290"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="343"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="426"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="10">
        <location>
            <begin position="680"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="10">
        <location>
            <begin position="732"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="811"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="862"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="101630" checksum="3133209DD0AA6EB4" modified="2021-09-29" version="1">MPVHKINEISHKKVQCEYMMCDGGSKEGQVRRACRTMLRFLDVPDPCRGVVCGPGALCRPTPDGRAYNCECPTSCPSYGDHEGSRPLCASDARDYPGDCEMRRAACESNTNITFKYYGKCDPCSGVTCPDPEVCQLDDRRSPSCRCAEPCPLEFSPVCASDGKTYSNECQMHRESCRARKQLKIIFKGQCSSGVNPCAEVECRHGAECRVEGGGAVCACPPPCEPVLRPVCGSDSRTHDSECELRRAACLLGRELRVLHAGACGSNGVCADRVCPHGGECVATGGRGVCRCPRCSNEFAPVCGSDGISYGNRCKLQLEACRHRRDVQVLYDGPCNGCENKKCEFYAVCESDGVSEASCVCPKHCEEGTETEEVCGTDNKTYSSVCALRDTACKEKRRIHIKHMGSCESCAEIVCPAGTWCARGSCGCQAACAEAAREPVCGDNRRTYPHHCALRRSACEAKARGEPPPRVAYYGECTEQDENNTADGNRSSKYTDLSNEIRAGDENENASEAVTGTAVCARVQCAYEATCAVDSNGQPRCACLFDCAAAAAAATSSAPVCASDLRLYPTLCHMKLEACRRQEDLRLRPLPVCRGLEFRPCGDDEPLTDAEGRPIDCGGGPHRKDCPVGSYCHHTAKAARCCRKDKAVVEKKGCQESWHGCCADGVTPARGPGGAGCPAVCGCHRLGSVNEQCDEEGQCACRPGVGGQKCDRCEPGYWGLPRIGTGHTGCIPCGCSAFGSVREDCEQMTGRCVCKPGIQGQKCTVCSNHEHTLGPNGCFDPESTQLPATNCDHMTCYFGAHCVVRSGLATCECASTECPPADGPSVCGSDGRTYLSACHLRTHACRTQSDVVVQAFGPCSEEAPHVRRGSRASRSNRSSLTRQNSDLHTNTHMETDKTSLKDFEYIKQSPNSLQFTDASVDTSDSGKPDSPEPELTCIDILPPIGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMK1</accession>
    <name>A0A835GMK1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMK1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="279" mass="31425" checksum="4F2611427A98F075" modified="2021-09-29" version="1">MVSTKAQDFNSRTMLRLQQQLKLLNHVYGAACDNQYLLTTMPQYAKRITISRQMSDETNWHKLDAELLRSLVGGSTWLCNGAILIPMDRQRRKAGPRLKRCTGCGELMSRQNGATKSNSLFAKSGDEDGVCERCRSPMHAPPIHLDMKKKKVKQSAPNPRPGPGIQTNRSSKQRSRLDEYVNLYLLLMPLQKPLALPIAPQKRGLSTCFGERADFETPAARASGCVYILKDSADTEFEQPESDEQSLLDWRDPFTTKVQLANPTDEEDPDFKGHNITMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMP0</accession>
    <name>A0A835GMP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HW555_002220</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">BAW_Kor-Di-RS1</strain>
            <tissue evidence="24">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14143">
        <property type="entry name" value="STKc_TGFbR1_ACVR1b_ACVR1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23598">
        <property type="entry name" value="TFP_LU_ECD_Babo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000023">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032903993" description="receptor protein serine/threonine kinase" evidence="21">
        <location>
            <begin position="35"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="23">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="348"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF9422000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="648" mass="73666" checksum="C91BF1F7E1702165" modified="2021-09-29" version="1">MFSSRNVIMNSFQWRKWFLFLIFAVYRRLDTVDGLKCYCNSERCPNSTCETDGYCFASTSLENKVQKFTYHCIELKSLIPIEHPFSCSTTKTKNESVVIKCCKSHDMCNEGLRLDLQPKPPGRSDVEVVPSMCPANYCTLASRSSHSTPTNAKCPAPILQRVPWFMTGIDHHRVGYILFVLIYEFMDVDVGTKKTYCLPGTCLYGAAEKTPKYLAAPRSTVTVTYSQPYLCCLECFVPLFCINITNTNPYILNKETGTTATAWKVLPWVMGLMVLGVCAAISFWWAKRSHGPKKRVPSRTPYPTDDPGSEARHPMMRTTTIRDMIELTTSGSGSGLPLLVQRSIARQIQLVDIIGKGRFGEVWRGRWRGENVAVKIFSSREESSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLITDYHENGSLFDFLSARTIDSMTLVKMSLSIATGLAHLHMDIVGTKGKYIRKPAIAHRDLKSKNILVKSNLTCVIGDLGLAVRHNVASDSVDVPTTNRVGTKRYMAPEVLDETMDTRQFDPYKRSDVYSFGLVLWEMARRCGVMPDEYQPPYYDCVPPDPALEDMRRVVCIEKRRPNVPNRWHSDHVLSSISKVMKECWYQNPAARLTALRIKKTLANICTPDYIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMW9</accession>
    <name>A0A835GMW9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_003376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000005">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000015">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF209">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="455" mass="51925" checksum="5ED6D3F60EDA6B88" modified="2021-09-29" version="1">MSTTLCSQFLSFVLRTSLPVAQFSRGDFSLWSVLKNCVGKELSKITMPVVFNEPLSFLQRMLEYLEYAHLLRMASEQTDPVARMELYLITAFAVSALASNWERLGKPFNPLLGETYELERPEFRAVCEQVSHHPPVSAFHADSPHFVFHGSVHPKLKFCGKSVEIQPKGHVTVELPRWGEAYTWSNVNCCVHNVIVGKLWIEQFGAMEVTCHGGAGLKANLVFKPAGFNNRDLHRVDGFIVDANKKRIKFLYGKWTEYIKCCSAAAYEQWAKERGEEASSQTPSHTPKKMLAKLNSFKVGALRSMSIQDSDDAENSEDVPKSDDTNNIDIAGSVTLWEARPRPTTSAQYYQFTEFAMSLNELERDMKGQLCPTDSRLRPDIRLLEQGDIDGAATEKTRLEEKQRTARKLLKKSPEAWQPRWFSQGTNPYTKQEDWLYNGGYWDRNYQHLKDVDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNH0</accession>
    <name>A0A835GNH0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNH0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38529" checksum="1C2DA27EE6CDBB34" modified="2021-09-29" version="1">MYHDPEDVDNKMQERFDDMYYQTLDFPVQHWDFVLVYHILSKIDPEVRQSLEEKYSDVEIPSFDQVKSFLRAKSEALIRGTHFTATTKLKSNQTAPAVVTSQSRRTPLLQCLLLLLILNKPHNRINSSHQLKDCKSIFTCRTCKRKHHTLLHRERPQPQEPNPTVSALISKSHLNTTVLLATAIVQVRDASGRMQSFRALFDTGSQSNFITESAVKSLGFTPAKVDTKVSGLGEAMAPISGDVTCSVGTSTRVYYKLNMHVIKKICGDQPIAQLNTSGWSHIKSLTLADPGFDIPGPIDLLLAADVFVESILNQRIKGGYNQPTAFNSIYGWLLLESSLRNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNM2</accession>
    <name>A0A835GNM2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_003840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000040">
        <property type="protein sequence ID" value="KAF9419721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNM2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF62">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="15">
        <location>
            <begin position="160"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9419721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="271" mass="28110" checksum="9C6E926CD55079FD" modified="2021-09-29" version="1">MKVSEIMKIGFIGGGRLAFALANGFISAGLAKPDEITASVHPADKLGATAVFENKPVVERSEVVIVSVKPDVVVPVLKEVKDLQASKNKLFISVAMGVSTAAIEKVLPTEARVIRVMPNTPALVQHGAAALSRGTRATADDAKLTTQLFQAVGTCDEVPEYQMDAVTALSGSGPAYIYMMIESLADGGVRCGLPRDLALRLAAQTTLGAAAMVKTGTHPAVLKDNVTSPAGSTADGTYHLEQNGFRSAVIGAVAAAADRCKVVNSQLNNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNY0</accession>
    <name>A0A835GNY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_004038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000131">
        <property type="entry name" value="cyclin-dependent kinase 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="81"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9419390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="45204" checksum="E0B705E48CC538DE" modified="2021-09-29" version="1">MEWSGGGGNGEYRVRRQLSVSSDSKLLDEGAREEARVVMRPKRPPRPKSEAFLGPHDHSNRRTKRFSAFGGDSPFGKSEAYIKLEQLGEGSYATVYKGYSNLTQQVVALKEIRLQEEEGAPFTAIREASLLKELKHANIVTLHDIVHTRETLTFVFEFVDTDLSQYMERHPGGLNHHNVRLYMFQLLRGLSYCHRRRVLHRDVKPQNLLISSHGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMLCGVPTFPGVRDTHDQLDKIFKVVGTPTEESWSGVSRLPGLRAHVSRWGTSPARALGAAFPRLRDAGRDAERLAAALLQPDPSRRLPALRALHNAYFASLPPRLRDLPDEVSIFTVEGVCLHPETRHATIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPM9</accession>
    <name>A0A835GPM9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_015553</name>
        <name evidence="6" type="ORF">HW555_002716</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000526">
        <property type="protein sequence ID" value="KAH9635979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPM9"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9635979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13270" checksum="6E2577F0EB55FFCE" modified="2021-09-29" version="1">MTRKRRNGGRAKHGRGHVKAVRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDINEASVYASFQLPKLYAKLHYCVSCAIHSKVVRNRSKKDRRIRTPPKSTFPRDMQRPQNVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPQ4</accession>
    <name>A0A835GPQ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPQ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27223" checksum="E18DD239DFE2367C" modified="2021-09-29" version="1">MSDKCSIQNVLKFLEDPKYPSVGPHLKLLGFTGLWHPNRQTTVLGHIVSAYVVGWDTLVVSIMIFFAGQLKITCMYCRLAIDLLNSSKSHDNIAQCHRFHTTLVEYTHLFNALISPVMFVYLVVIAINLGVCIIQIVEIHDDIATLVSSILFVVACLIQLLLFYWFANEVTIESTFVSYSTFESDWPQANNKLQKEIALLGLTTKKILVFRAGPFNQMSLTTFIAILRASYSFYTLLNSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ11</accession>
    <name>A0A835GQ11_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ11"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="156"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="35304" checksum="0E5D09771E778D3C" modified="2021-09-29" version="1">MAEPIKVVVTGAAGQIAYSLLYQIASGAVFGPNQPVYLHLLDIAPMMGVLEGVVMELADCALPLLAGVLPTAKPEEAFKDVVAAFLVGAMPRKEGMERKDLLAANVRIFKEQGQALDKVARKDVKVLVVGNPANTNALICSKYAPSIPKENFTAMTRLDQNRAQSQLAAKIGVPVQNVKNVIIWGNHSSTQFPDASNAVVNIGGAQKSVPAAINDDAYLKSTFVTTVQKRGAAVIAARKMSSALSAAKAASDHMRDWFLGSGDRWVSMGVVSDGSYGTPRDVVFSFPVTTANGKWKIVQGLTITDFARQMLDATGKELAEEKQEALDVCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQC1</accession>
    <name>A0A835GQC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="75"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="413" mass="45474" checksum="0A421F0C78D851D3" modified="2021-09-29" version="1">MSALQKTIMKNKLPPRVPRTSGVSKMAPFGAGRRKDYTPVSWKQYFHQSVDVEINAGTFRVYLSPEPDHPDRPRIVTLHGGGYSGLSWSLFTEEITSMIHCQVVSIDIRGHGETKVENCDDLSIETLVYDIEQVLHKLFSDGIPPLVLVGHSMGGAVAVRVSLQPSLEHCIQGIAVIDVVEGTAMDALASMQSFLRSRPTHFKSIEHAIEWCVRSGQVRNVDSARVSMPSQIINCETGKLAINEVESYTSVSDESLPAPTRHAPLADRIAEESDGEADGESETCPEDTVEHFIKPSAVGDGNSSMKYKWRIELSRTERHWAGWFRGLSAAFLSVRAPRLLLLASIDGLDRELTVGQMQGKFQMQVLTRCGHAVHEDTPGEVARVVAAFALRHRLTCPTELGADMQLLHTVPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQH5</accession>
    <name>A0A835GQH5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc transporter 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="54"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47060" checksum="15C9D3BCA54FDC90" modified="2021-09-29" version="1">MMRSWDLKERESVFVGKMKKLNETYTDVPVAPSSDVEHCHWPPPAQPPSAIPQLLIALVLCGIFMVCELIGGYLAGSLSVMSDAAHMLSDCGGFALALLAFHCAKRRPDVHMSYGYKRAEVLGAMLSVLLIWILTGIFVYVAVVRLHTGEYNIEPDMMMIVSGCGVGFNVILALVLHGCASDIAHHHTHGGAACSHAHAHSHNTGSSRGWRLFRRARDHKHTNGALANGDYNMKDLATVEASVVGSQPRNINLRAALIHVIGDLIQSCGVLLASILIKFYPEAKVVDPICTFVFSFLVLLTSAQVVRDALAMLMQAVPKNFRYRECVAALSSVPGVRHVHSLHVWALSTHYVVLSAHIAIVHSARSTGCPCAYNTYTYSSDELTDGESVLRACQQVARTEHGVSLCTLQVERYDVRMRSCPDCALQPAHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSF5</accession>
    <name>A0A835GSF5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSF5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="219" mass="25597" checksum="BA784CDD67DD4BAC" modified="2021-09-29" version="1">MYPNSVKTKQLSKLDTLFLYENRLIAYYMEHITKRKYILYRRKRDTSAHRGVRSRTGASLHNSVARRSNQGSYPTLGSRANSYSTLGNRVQQFLPEKPASKDLPCLLEQCENEEQRRGVQWEVRVQCELMARASAALTRINMAWRRTSTAWSLWRSCVLLCATPRTPTPWRCKCTTQISKPINWISPNDKFTFSCPQEQTRVLYKLKYKSYIKEESPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSH7</accession>
    <name>A0A835GSH7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSH7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="2">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="308" mass="35920" checksum="1D9D5771EB158DD7" modified="2021-09-29" version="1">MAQTIRRAIEGRYPSCYIPSRIKERRAKARALRLEQQRKPDKPEDFVCYSDSDSEEETPAQQHKILSTSYNFVDYVRSREIQSNEPRSVEPSYATRHMLTHDMFRETPINLGNMNKVFCSQWLSDRQVVFGTKCNKLDELEHSSTQRIARIRVFKFRVDYFTDLDETDFFARFRLSKYAVNQVHNFIKHKIMPKSQRNQAVPTKTSLLLTLRYLATGSYLRSAADFCGVSPPTASRIVKKVTEAIAQLRTVIIKFPDNLSTLQDGFYEIASFPRTLEEIAAQSPELNYDPRNRLVQEYFLPLLNNNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSZ2</accession>
    <name>A0A835GSZ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSZ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27730" checksum="0D758904EF1AB593" modified="2021-09-29" version="1">MYNFVPRYPTYSPSLCTDRRCTLAILLSFILPPILCIPSYFVFTIHKDFAFDKSGNMLTKVYFVDSNYNGSLYQINFWVHAVLIKLLPCVILTVISAWLIRALYRANSRKKALKGYSACPATAVVNGNGNVFTRKSTKRSKAERRTDRTTKMLVAVLLLFLLTEFPQGILGLLSGVLGRCFFKQCYDLFGELMDALALLNGAINFVLYCSMSRQFRTTFGQMIRNRCAPTQRANSHTELQTTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTI6</accession>
    <name>A0A835GTI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 4 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF22">
        <property type="entry name" value="NUCLEOLAR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="544" mass="57549" checksum="4A98440792DFB560" modified="2021-09-29" version="1">MLKEAVYFERPKTFNSPLRSFQRRDNLTPEPADMNDDDNFSSQALAKDAEKLKMMLLAWNYHSQAQGRNGDITETGGDSMADLWASYHSALGLGSKPPKPPTPLAAGHSSPIHVGSVTPGVEPASTHDETSSSDRTKDDDDGGASDDDSDDRVDPQHHDPERLKAFNMFVRLFVDENLDRIVPISKQPKEKIQAIIDSCTRQFPEFAERARKRIRTYLKSCRRNKKVRGEMPSSGNGGSTPGSGNAWDTAVRPTPAHLTSVQAEHILAQACENESLNAKRMRLGLDPVSQPMPTVPTPMAIDTTATSAVASSFLSLYSGAISSPASTPATTTSTTSLATAGHSKAAADTTRPSASPTMDTSLLNNNNLKLDNANGNAGSKTASPASSPAPLFRPSFPNTFGTPQSFGRQNSNPNPASSALTSSALLSTLTALPPTGAGVNAAMAAYQSALLSAMAAHTHTFPTSLSAPTDLSLKSTTPTPLHATSTASSLASTASSQSKPQLLSHKLSGAEVGAVRQLITGYRESAAFLLRSADELEALLLNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTT2</accession>
    <name>A0A835GTT2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_001594</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTT2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9422810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57008" checksum="39DA363484CB06C4" modified="2021-09-29" version="1">MIWQLFVSVVILYGLVLRWQARHRIKFAKLYKNDIKAAPILGHSVHFIKCKNNTDRWKVLEKFGREAVKQGGTTIGWNLHRLYFIVADPVVAECVMKHCLDKDDSMKLTLALIGNGSSVADVPIWRPRRKILVSTFSQKNLLAFTDIFAKNSDIMVQQLQKVAGTGSISISEYIMAYAMDSVRETSLGLNANSQLNPNQDLIKAFAGSCTLIADRIMKPWLHFEPLYKLTAHHAKYMEYVDTVLGYIMEMIQAKRKELAEKKFIKKNDEDKERIKSFLELMIESSGGDKGYTDKELLEEIMVIFTAGTDTSTLASSFASMLLARHPDVQEKVYQECKDVFGDSNLPVTAEELSRLKYMGAVIKETLRLYPPGPILLRKVDNDVVLPSGDTLPKGTGIFVSIFAANRNPRYWGDDADQFRPERFIDTQLKHPAAFLSFSYGPRNCLGYRYAMLSMKSVLSNIVRRFRILPVSQLELGKPLDINYDIMLRSADDYKVVLESRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUT6</accession>
    <name>A0A835GUT6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial</fullName>
            <ecNumber evidence="7">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aminoacetone synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:20738"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUT6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="112"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="464" mass="50680" checksum="DB1DEDF2036AC6E7" modified="2021-09-29" version="1">MKTKLCLNTRNGTTCVTGLLKSWSALAPHRPAAAPPFVAMALRSQLLRNCLNGTHTRQFHELHKERAGVAKLRDVLEDRLRDIKRAKTWKHERIITSPQDTKVRVQGAEGEFLNFCANNYLGLSNHPEVVEAAREGLKKYGAGLSSVRFICGTQSIHKELEHRLAQFHNREDAILYGSCFDANAGLFESMLTPEDAVFSDALNHASIIDGIRLCKAQKFRYPHRDLKELEHLLAHSEARIKLIVTDGVFSMDGTVAPLKGLRDLADKYRTLLAVDDSHATGFFGETGRGTEEYLGIMGAADIICSTLGKAVSGAAGGYTTGPKELITLLRNVSRPYLFSNAPPPPVVCASIKSLDIVEQSGELRQRLRENTRAFRDGLKSAGLMVAGDDHPICPVMVGDAPLAVELAANMLKHGIYVVAFSYPVVPKGAARVRVQLSAAHTQDDVARAVQAFTDVAKEIGIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KW48</accession>
    <name>A0A835KW48_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_014332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000983">
        <property type="protein sequence ID" value="KAF9404440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KW48"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9404440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="403" mass="43648" checksum="318DEBBA42BF55FA" modified="2021-09-29" version="1" fragment="single">MGGVASDSGESDCSQLSSVSQMSTASKTARARKRTRTTAWSAQAAVESMPESDKDALDRLAKENADLRSQVASLKEAVSGLKNQLNLLSQQGAQQKSQPVRICWSGTRYGSAIATFHRHRDSPAGIVTSAAKDVRPGTANSQDTTTWSLVVGRKAKRASAPQPMVSFASAAQSKPLNKPSVKLPKVPTSAAITVRVREGSNVGLGKYLLRQEDELVFPNSALPVTHVVRNVLLMADRLASRMREVLGEFDVQIGRPTKFAEARVMDLNDAVTPEEVAVAIARAGGCSTEEIKIGEIRRPPLSLGHVWVRGPLVAMKKLASDKRMPLGWTSVRVEVLEPRRMMCYRCFESGHVRRMCTSSVDRSSQCYACGGAHKARECISPILKCPVCSDQGRPSNHRLGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY05</accession>
    <name>A0A835KY05_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000673">
        <property type="protein sequence ID" value="KAF9405839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9405839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="71872" checksum="2FC598DA20AC29BD" modified="2021-09-29" version="1">MTNIHAISTTYFIYMKPVEEMRGCFPKTMGQKMYLTWRSLRGRYLHLCLHLQGKSCFIIKVPGDKNRYEVSILIMSENNRNLKIHNTCRICLFTTDNVEQFVFLNEDNVWFERFEFCFGIKLTAQDQQHVLCLMCSIDIKKFICFKEKCLQSHRLWESLMSDVRCNIVKIDCIKNVTENVCNAITKQIKSENLDPSSDNDQNFLPDGDDLDNFIEIKIEHNENDESRQQTGNDVIEKVSLKNHVKQKPLKKIKRNDSAEIEGKKLFSCKKCHKKYCKNFIFNVGIFWGSYLKHENSCSTKKSMKSQVKLWNTPDYHWDNNDLACQLCDFVGIDLAAIAAHRYYHYPREGKVHYFCHICRHKLLSLMSLHFHYRKIHLGKAGGYCAQCNKEFHGLTFWKRHERKKHSAPKYICDICGKGYSFKYSIKDHMINSHLGIKQHICDICGNCFKTKKYLKLHIRVVHTKTEPLKCTHCDKMFKSYHTLNVHQRKISMEKNYKCEVCHKAFTNSNALTMHMVTHSDERPFSCDICGASYKYKSHAKVHMLRHSGFLPHKCSQCTKAFATTTQLKVHSSVHTGVRRHACIAQNCVKTFHSKKLMFAHLQSRHKNENLEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0M2</accession>
    <name>A0A835L0M2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0M2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="351" mass="39791" checksum="7526903BFE1C8210" modified="2021-09-29" version="1">MSIVWNNETELAFIDCYRAEPVLWDINLKDYKNKLKQHDAWMRVSTVMEIPIEELKKKKDSLMSSYRSYKGKVKKSIQSGAGADDIYQPTWFAFEAMNAFLGDNLTCKKTMNTETGEEPTEAIEENDINENRSQSMNSQKDSDHSIRRRKTSSELVEAGNVVKEALATFKSTLKRNPSQPVQQEDDCDLYGKLLANKLRKLSEKNKLQLMHDIDGLYLRYKCDDTVMSPSPPQRPGTSSSTYSESPLHYGQANQNTHYQNRQAVMSPSPPQRPGTSSSTHSEPPLHYGQANQNAHYQNRQVLSAPASNIIIRSHQLVRAPDYPVLHIPENQGEKTSNENFGNIIQSAFDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0N6</accession>
    <name>A0A835L0N6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein yellow</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_012489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the pigmentation pattern of the adult cuticle and larval mouth parts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000464">
        <property type="protein sequence ID" value="KAF9407499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0N6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF14">
        <property type="entry name" value="PROTEIN YELLOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032339092" description="Protein yellow" evidence="13">
        <location>
            <begin position="38"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1092"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1233"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="14">
        <location>
            <begin position="547"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="14">
        <location>
            <begin position="866"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9407499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1267" mass="141430" checksum="CD6A31E2A847894F" modified="2021-09-29" version="1">MKFTTNCREHWPHSDNHISNMATKLLVLLAVVSSATAAVKLQEMFSWNVMDWNYPDPYSRQQAIQSGALVQENALPVGIERWRNKLFVSVPRWKAGIPATLNYIPLDAPYDPSPKLNPYPSFAGNELGNCQSGLNTVYRIKVDKCDRLWVLDVGTYGYDANVTNLCPYSLNIYDLNTDQRIRRYVFRPEDIVSSTFIANIALDEGRTCDDTFAYFSDELGYGLIAYSWQQNRSWRFSHGFFMPDPLTGDFNIAGLNFQWSSEGIFGITTSPAGPDGYRTLYFSPLASHTQFAVSTRILRDETKVSGSYRDFQVVGERGANGHTTSKVMDEYTGIELFNLIDQNAIGCWRQDLPYKPQNIAVVDKDDAGLIFPSDVKIDAQRNVWVMSDRMPVFLESTLDYSDINFRVYTAPIDVLVQETVCQTASQLVQTPKPVQQTSIIPQQPTYSFYDTGLGVTGNPLAIQGGSLSLYSPVSSPQPEIASTFRPGAIIRNSIPTVQSYINFPKQTAIPYFAGRPKSYIHSSRNPWWHDKLKGEYNPYEHRKVEKPTSNIRSTANLIKASLGSGLLAGPLAFSNAGWGVGLFGTLLVGVICGHCIHILKRNRPLGYAETCKAAFMNGPKGARRFAKFASIFAEFALLLTYAGVCCIYTLNSWSIVMRHLPFLPVEYYCLMILVPIILLCQIKYLKFLAIFSGIANILLFTVYVVCLYYIFGGDITFEGKQAAGDPARYPAFLSTVIFAMEGVGVVMPIENTMKKPQNFLGCPSVLVVAMGAIVFLYGTLGMFGYLRYGDVLRGSITLNLPTDEWPAVLAKVSIALSIFLTYPLQFYVVIDIFTRYTQPHIKENYQQITQIVARTIGVCCCVIKDLRSLANLIKSSLGSGLLAMPLAFSNAGWGVGIVGTVIVAFICGHCVHIFVQTSRGCCRLERKPLLSYSETCRSAFANGPKCVRPLANFAHLFAEFSLCFTYLGVCCIFTVLIATSIKQLFDTYLTTTDIPVEQYCLILLAPLCLLCQIRHLKWLAPFSLLANILLFATFAICIYYIFREPLTISDKRIVGDLSRLPAFLSTVIFAMEGIGVVMPVENTMKKPQHFLGCPSVMVIAMSLVMCFYTILGVFGYLRYGEALKGTITPAICAKAFISVTIFLTYPLHFFVVIDIFTKYVQPRVQEKYHNVMQISARILIVCFCGGVGIALPFLEQIINLVGALFYSILGLIIPGIIETVFRWEDLGEFNWILYKNIIIVFCGMFSLVSGCTVTISDTIEMIHQKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L199</accession>
    <name>A0A835L199_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B-cell CLL/lymphoma 7 protein family member B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_012226</name>
        <name evidence="3" type="ORF">HW555_011851</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000590">
        <property type="protein sequence ID" value="KAH9634812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L199"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9634812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19575" checksum="E5536C82C6135DB6" modified="2021-09-29" version="1">MNEIKSSNPLIVANLLKLIRKQILYFIITGVAVFEKSKKMSRSVRAETRNRVKDDIKRVMQAVEKVRHWEKKWVTIGETTMKIYKWVPISTNEQKKKHAAKRENKENTLTPKKVHDSSNSNFGMAEDSNTCFSTVSDSQGPTEFTSTAMNFSEDSNSQSSGTTTPAKRLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L214</accession>
    <name>A0A835L214_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000764">
        <property type="protein sequence ID" value="KAF9405301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L214"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="560" mass="64005" checksum="00E8AD53394DC04D" modified="2021-09-29" version="1" fragment="single">FLLKITQSIPKSQQVMGPALAVSAAINALSKGIRLEHRRREQLSLELRPTTTTIIPNSENSSPSLWSGHEKNMIDIDAATSSLLSTSDGMPSELKQYLDQPIIPRKENPTKFWFVCRHFTPVLSDIALKYLISPASSVSSERLASAVNLAVPNNRNRITAEHTISPNEFHTWTGLNHDQYTDLLANTPSVNNRRDSNARLATIFRTSESSFARMLKTGRIALMQDFVPLHLGFDHLIREDQNLLKPFLFACCDGHIIEVSGPHAATTSDAQVMNNKKTPAMAYFIGSTGMVIDFIVPMQQHGYSVHIPESKYPNETHRTTDQANKSRLITICRWVVEVVNGRFKRVFRLLRNIYINRTLYYMFEFFKIAAALINAYHRLIDDNIHEQTFLNIINERLTLTNILADIVKRHNYNRRRVQFRSLSADVGELNDFPRLTEEDLVLVVLIKQARSYYGEHLNPNGEFVIEIESGVLTEHARELGENVVIIRGRIQSRHVRTYYVYFGWNTTLSGREAIAHYYCTCNVGKRNVVGCCSHTMCLVWYMRFARQKKLIGPARRGRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2I6</accession>
    <name>A0A835L2I6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000650">
        <property type="protein sequence ID" value="KAF9406037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2I6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="36638" checksum="AEF018A36F666A62" modified="2021-09-29" version="1">MDNIIENKDTDGATLKHKNDAWIRVTAEYNASPLTTKQLNNYGADVSMVAPALIVGIDNAIDSDLVEESSQSQIPDAIEIDEHYEYKDLSVRATEKHNLEMQILKEQLRGAKAKADLAELILKEKQNSTVVDFIIIIYFGNNIFNIHSSRERLKYEFTISSPRSTELNNRDLDNHPNVDLETRVTFIKQYGLRMGSHTLRDREIDDLLHQYDSEDRLEDDDDSVIDPDFQPLLEGLEVFSDFEGDTAVDIDAIVEEFECTSFSHGKLCAVYNNGFSVSNKNEKWLFSNKVCMSTGQTRSFHGEPTCRYKKEKTCYNRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2M3</accession>
    <name>A0A835L2M3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2M3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="571" mass="66918" checksum="9F52B319071D91F4" modified="2021-09-29" version="1">MEINSGSRAKTILDMVKEEKSNQYKPTRKPDPAQDMKKPKQPEPKTKPGPDLTEFINRIYAEPYSMTSTVFDTFCETQVTYNSHHLLSLSTQSLFNEFKISPHQNTVNLTEIDLTCNELMLPLDFSPLDEEIPLNMEGTCENSPLDFDSDDSVIDKDYCPSDSSQSHMSDVPESGRKTKKKTMKTNNGNHCSILPVDNEDRMFFNLKSRRRNSIGTCKESTPERLCHRKRCKSVDGNYCSTLSDILQLPRKRMKHNTPLQQRRLDAKNKKKREHCVKPGCNEKCLKKCMTLLNQEDREAINKSYWDMSWQEQHAFVEAHTYVAVPKRKITSEPKRNPRRNFVLKKQDGTRKDVCKIFFLTTLGYLKNNDRILHPTFTNSSIDKRGKHQKTPAFDRDLLNQHVESFNPLEPHYRREHAPLRRYLPSDVNITQMHKHFCETYPDRQVSYSLYRSHLKNMKISFTALGNEECELCESYNFHKKETSHDATVQILQNCTVCVDWIEVFFVRKSYDLMYKNNFDDAYTTLRFMNDRYLKNPRTMVFKFRTEPKGIEPKRKADLLKNLSICSIVDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2T9</accession>
    <name>A0A835L2T9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_009061</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2T9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20835">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20838">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04014">
        <property type="entry name" value="C2_PKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000063">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000056">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF14">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="36"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="511" mass="56660" checksum="A7CD1F8C6F4A66E7" modified="2021-09-29" version="1" fragment="single">RSDLLASTSSVAPASLSSRRRECNSRAQSQRRRASALSTTHATPSVLSNTMFSGTVRVRVCEATGLRPTDFQKRHNMTFGKPDDQPIDPYVSIDADEHHLDRSSTKPKTFDPVWNETFIHEVHNVGSLGITVFHDAAIPPDDFVANCTIPFEDLMHRDKDATDFWVDLEPQGKLHLKIDLKWNSQAGVEAPRGAGAGAGAAGREFKEGAGFARRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGLGKQGYQCQVCTCVVHKRCHSSVVTKCPGMKEEQQSAVGVSGGQRFNVNVPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCEVCSMNVHKRCHKNVANNCGINTKMMAEILNEMGISPDKNPRPRPSKYLNAALLEGAPDLASSGDSDNKDPDKHDDKGVDAPAWGSHWAELQEIFTCYDTEPEDGATTTTFCGTPDYIAPEKSKREAANFDAEFTKEEPVLTPVPHDVVRAINQEEFRGFSFVNKDFNPAPAADKPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L312</accession>
    <name>A0A835L312_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L312"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9650" checksum="CB4EE874D7921082" modified="2021-09-29" version="1">MWAETVAFSGGKLRVGSYWVLYCGTWHIMMRLCMSIFPLASMLLTQVLTGHYCFGEHLDKVRRDATANYHHCEGLLDSSQHKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3R2</accession>
    <name>A0A835L3R2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3R2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="276" mass="31404" checksum="B657719D30F3A532" modified="2021-09-29" version="1">MSQHRNLSVVERSSIINLRDSGLNISEISRELNMSRNTVKLWLRRFDSEGSLERMPRMPQPSILTQERVQRMVSVYEQHPFTPTRLFAEEFDCTAQTIRNGLRRAGIRNRKPAKKILLTEAHKTARVRFARDYRDFDFSRVIFTDEKSFKSSQIGRRHLWRVNNTRYEPRNVLPNNESGRVVVNMWAWMSAAGPGELVYIPGRATGATYLELLQDTMLPTCGMPRTLYIHIGAGVARDTVVAGFAAAAATAAAKAAEHGTLLRARVARRAGYFRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3W6</accession>
    <name>A0A835L3W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3W6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="37"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="30521" checksum="DDBE23B24B178F8A" modified="2021-09-29" version="1">MALIAPAMFVNHGGGPMPLLGDKDHAGLTNFLRDGVQKHLNLKEIKAIILVTAHWEESVVTISSGKHHDLYFDYYGFPPETYKYKYDAPGDPALAERIHHTLKKAGINSKLDSKRGWDHGVFVPMMLINPSASVPIVQISVLSNQDPEQHYKLGQALYEFRKEGVAILGSGMSYHNMREFMLGRHQSSVVNKEFDEYLNKVCTAESEAERKEGLLSWRQQKGATEAHPMRAAEHFMPLIVIAGAGGSKPGQRIFNWDMSGVFRLSAFVWKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4G5</accession>
    <name>A0A835L4G5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum resident protein 29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4G5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum resident protein 29 C-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="19827" checksum="BA17FB26C2B18150" modified="2021-09-29" version="1">MVKKKMRLLQRSMERPRTTSLWLNCSSKVNLKPIPFDESKGFTSDELRRFVRENTGIYLSLPGCVKELDKFAIQFMKGKKDERKKVLKKVEEFLKNSDKEPASGKIYRTIMEKILEKGDDFISAEHERVKKLLSSKVSEEKKKELGIRINILQTFQLSDKQQKTQKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L534</accession>
    <name>A0A835L534_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L534"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="213"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="337"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="582" mass="64113" checksum="CC42F4C5C9B4DAF5" modified="2021-09-29" version="1">MASEELVTEQFQFFGIDVPNEVINKCVSLCDEYNIDAESFIEQWMAFSLNHLNGSSPNLDNLDTFVRKEFSKRAANRSNATSKENGQVGTGSSLTVYGAPASVQSDNEVLSDYMATTPKRVKVEIESVSNQTNDLCPASYSPSVGSNKYATRTNVGAVVHSYGDEKLLQNISEPCGHDILNLKITQVPNDDGDTYNKAMFGFELLHEKASMFDGNIRYVSQCIMKKSGIKELTSVRCKTQAEVAVAGRIECDADARLNPKSVVLQGTWEQSLSQTVPVDLDNLKQYSLFPGQTVVMKGVNTRGDKFVAHEVFCDASPAVTDHKADLTNTLQGKISMVIASGPYTTSDNMTYEPLKDLVTYISTHQPHVVIMTGPFLDSEHTKVKDNTMAETFKSFFDKLIDSLGELSNTSPYTKIYIVSSNKDAFHVNIYPTPAYCSRRKHTNIHFMPDPCTLNISGIIVGVTSTDILMHISQEEISVGMGGDKLSRLAGHILMQQTYYPLWPPAQSLSVDAALWAAHAQLSCIPHVLVLPSNFRYFVKEVNGCVVVNPEHLTKGTGGGTFARLLIQNLKDDKKIAAQIVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5G2</accession>
    <name>A0A835L5G2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_006353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5G2"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032947815" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="37898" checksum="9FD477256C5D66CE" modified="2021-09-29" version="1">MLRSLFVALAVSAVFAGVPTPEETKRIMDRLSEAEHFKNEHHNKQFDHDAFLGEDQAKTFDQLPPEESKRRLGIIVDKIDGDKDGFVSLVELKDWIRYTQKRYINEDVDRHWRQHNPNNDDVIPWETYRKNVYGFMDEMDPKELKTPNSEGFTYSNLLKRDRRRWTYADADENDALNRTEFAAFLHPEDHSEMRDVVVLETMEDIDKDQDGKVSLEEYIGDMYKPEDGEDEDEPDWVKQEREQFNGYRDTNKDGFMDENEVKDWIAPPEFDHAEAEARHLVFEADTDADEKLTKDEILEKYDLFVGSQATDFGEALARHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5L3</accession>
    <name>A0A835L5L3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5L3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001909">
        <property type="entry name" value="WD repeat, SAM and U-box domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="922"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1120" mass="128900" checksum="1E77883AFF51EC2D" modified="2021-09-29" version="1">MQLSEIDNVKIYNLSVGKSLPDWLTERKKRALLKKNVDLRRKIELIQEFDMPGVSTTIRVSKDGQYIMATGIYKPRIKCYDVNNLSLKFERCLDSEVVTFEILSEDYSKIVFLQCDRYVEFHVGHGRHYRLRVPRFGRDIAYHRPSCDLFVVGASSEVYRLNLEIGQFLAPYVTKANEINCCAVNEEHGLLMLGTESGHVEAWDPRTKSRQGILDCAMHCTDSDYKNDKLPAITAAKFDGPLRMGVGTSTGHILLYDIRSSKPVLVKDHMNEIPIKTLEFHKTMNYVYSMDSTVVKIWDKNTGKQYTSIESSADFNDLCVIPNTGLNLMAVEDQKMQIYYIPSLGPAPRWCAFLDNLTEELESSASQTVYDDYKFITKQELESLGLDHLLGTNLLRAYMHGYFVDVRLYKRAKSIADPFAFEQYKKRKIREKIEQERPSRLKVEDNLPKVNRDLASKLMDDGGKKKKHTTNLLKDDRFKALFENPDFEVDREAEEYRLLNPVLSRLDKNKDKKTETETSMQVEETEEKDSDMELYDTSDGDSSDEDRTWVKEVKKQHKIIRNKSRQEEDSQPNEDQVFESNNGPRTTNIIKSITRVSKASLGDRLAKENFSTMVTTAGGNREMKFSMRGKKSETQNHKQMKKHHQERKQFVRRTGFLMKRKLPKYESLSLLFSVYPFQLSAKVYLASDLLDSHVLGNDKLAEPAMERSTRFSIDGNSVDIGEITESPDTEYMSTSAILHYCKSKILLPYLKLLTIMGLRPVLDVSNSSKCVICCSHFHSIQVAILMFVGYILQYMACFRRDRGFCYKLVPLALTSSLEYDNYKQVCYGNVIFTYIGPSILHFVGFLYALYLFRISDNEAVAKFNGKGMPTTKPKRLLRMLWFFIILSVIWMCLSLCSVNLMLAKGNIIFRWMENSSYEIRMALKVLLIICTLIHDMVQATIITSYCLQAQLLQAHLMFLKERLLNRTITPLNWMRLLKYLNDDLAPAVCLFTIVNISWATSGIMWLLNLDKVDTETEPLVGISILNELIWISAVIVPFVQAARLSKECRRTQSVGHELCVRPFLHQDTSQEDITSVLMYASTLRLHAKLFHYPIAGRYLCLVLTITVIVLFSLGMCHLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5N4</accession>
    <name>A0A835L5N4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Contactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_005199</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell junction</location>
            <location evidence="14">Septate junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. Contactin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005918">
        <property type="term" value="C:septate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008366">
        <property type="term" value="P:axon ensheathment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021682">
        <property type="term" value="P:nerve maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001529">
        <property type="entry name" value="Cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000047">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000064">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032915748" description="Contactin" evidence="15">
        <location>
            <begin position="17"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="275"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="386"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="486"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="571"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="669"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="761"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="861"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="970"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1074"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1177"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9417785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1314" mass="149960" checksum="529309E2D46516BC" modified="2021-09-29" version="1">MKCVLLLFALTSIVRSQVPDSVGTFNPNYPQQTYQDNNQNGTGLYRPNSQVPYGSFPVNGNDYNSGQSSFYQDNFSSDNYGNNDNEVDPQNTATYYAGLDYEERYRCPPNWIRFRESCYRFTKSPDRPRNEARKICLAYEADLASVNSPEEHGFIITNLMRLDPQKGSWYIGAHQQSPGYWSNDADGSQLTGLENAFFNDHSQIYTSYNILPRDYLVYKFSHQDGRWGLSPVEGTQYYHFICEGLSQRLHYLIEEERSFTYGLETYDPERIPRGPYFIKEPVDTIYDPMRNYHVQLTCIAGGYPAPVYKWYREEYQVDNPIYTEIDPLVDTRFVLSGGTLMIYTPDTDKDNARYHCTASNKFGTIRSESVRLSFGFIREFNQKRSVESGNQYWGKVMYCDPPSYYPAVNFLWARNYFPNLVEEDKRVFVSYDGGLYFSALESIDRGNYSCNVMSKVSDAGRNGPFFPLFVYPHSDYQHLKFPNNFPKVFPEAPVVGQEVRLECVSFGYPVPSYNWTRRNGNMPKRARLSNYDRVLTIPNVGVEDEGEYICDVKNDRAHISNSVFLKVQAKPNFTIPLADKHMDNKGELHWNCEAFGIPDVNYTWWKNGQKLTMDTLDPDDRDRYVIQDNVLIIKYLDPTRDPGMYQCEAKNQLKASYSTGQLRVLSLKPSFKKRPLESETYGSEGGNVTLKCNPEAAPKPTFTWKKDNIVIGAGGKRFIAETGNLIIRQLSRDDEGVYTCVAKNQYGTDESRGRLIVLRAPRFLERLPPRITTQVNQVVFLHCSAEIDPMLDTAYLWNHNGIRMKEAADLYADKRIKIDGGELTILNVSLSDVGDYECVVKSAIGRISSHTQLRIEGPPGPPGGLQTLNIQRSSVTLEWTDSNSNGRPILSYMVTGRTHWNATWYTISENVANVIEIDRYNGRKRATIVTTLMPWAIYEFRVQAVNQLGPGKPSAPSPQFSTPADKPYEAPANVGGGGGKTGDLTITWNPLPPSLQNGPGIYYKIFWRRNGTEVEFQSLSLKKYGNIGTYVVHISTTYFYTPYDVKVQAFNDIGAGPESEVVTIYSAEDMPQVAPQMVYARSFNSTSLNVTWNPIDQSRERLRGKLIGHRLKYWKQANKEEECIYYLSRTTRNWALIVGLQPDTYYFVKVMAFNSAGEGPESERYLERTFRKAPQKPPASVNVWAYNPTTVRVVWRYVQPTDEEEPLLGYKVRVWEIDQDMSTANDTIVLVEHKLEAYVMNLTPGKSYNLRVLAYSNGGDGRMSSPAITFQMGDYHTDAYGYSARSYAQNLQIPHLTLLLASVLLTVSRKWLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6E5</accession>
    <name>A0A835L6E5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6E5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000043">
        <property type="entry name" value="AGAP008687-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="366" mass="39906" checksum="7EF879839A5B6FA2" modified="2021-09-29" version="1">MSGPNGMLYGGDEIGALVFDPGHHSLRVGYAQEDTPKADIPAVVGVGPATHIPEPEEKVPDGNVTQSGKVIRSPSEHHPALFTEAVWTTRPAREKLAELLFEKYQAPAFFLVKSAVLAAFANGKSTALVVDAGASQTSAVPVIDGYALVNAAVRSPIGGDHLAAQAKHMLSNMHIQMLPIYSIQSKEVIRERERGRYTLKTLPAGLTHSWQQYMLKRQYEDFCHCVAQISESQYEERQAASVPFTHYEFPGGYHQDFGPERFKLTDMRGGGRLRRGRAACAVGLRRGLRRPGQHPGLAGALAKDLAARAPSSHRLKTTAAPNPTERRFAAWIGGSILASIGSFQQMWISSQEYDEGGKGQLERKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L774</accession>
    <name>A0A835L774_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L774"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="20921" checksum="07A3A3313F5B70B6" modified="2021-09-29" version="1">MTGPIHFHDGPCDQPAVVTGDVHDHTSYVVSYTWLSHGDLLTECFQKFHILLLRKAVIESLLSSLLNPLISPQGSVYFDVDASDQPAVLAGDVHDHPGDVVSHTRLSHRNIFLCNFQPLLILGVGAMNYVLQKVGYLRSNSDDSPGDTGDIDNVALGLDEGWRQQLGQQVHAPHVDPEHVVEDLHEYSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7D8</accession>
    <name>A0A835L7D8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7D8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23599">
        <property type="entry name" value="TFP_LU_ECD_Cold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF3">
        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032891662" evidence="3">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="14074" checksum="D725209FC0C2112B" modified="2021-09-29" version="1">MYKHCLLGCLVFLFSVINVLGLECYVCENQEDNNEKCVKTIKNCEYNQDVCLTEIKWGSTPYWSQGAKKQYYVSKRCSNKTECATTRHRYMPLCTHIWYQDWVCSDCCLGDRCNYYIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7F2</accession>
    <name>A0A835L7F2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7F2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="26239" checksum="D3136A9FA3E568E8" modified="2021-09-29" version="1">MIANSAWIEDNNIKPYQEFKEQLIKSCKTAAFKEAVNQIEEFIVHPEKFGDLDDHARNAEEEFDKLKDVLEEDENQEEKPADEEVAGPASEPTTSKKKSATPKIRLGISKVKPIKRSSSAGTKSTPRKKSKASMSRSYTDIDAANEKPSMLNHSFSKKSSLLHRPSNILRPDTPPLDLENVSETLLEKNIQASQMKFGFLGLGIMGSGVVKNLLNSGHKVVIWNRTAAKVSGLFGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Q9</accession>
    <name>A0A835L7Q9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Ornithine aminotransferase</fullName>
            <ecNumber evidence="6 11">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="6 11"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Q9"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="417" mass="45695" checksum="7AA1CC533F30C1AB" modified="2021-09-29" version="1">MRYLTDTSMVGQNDQLSSQEIFALEDKYGCRNYSPVPVALCRGEGVFVWDVEGKKYYDFLSAYSAVNQGHCHPRIIAALKQQAEKLTLVSRAFYSDQLGNYEKFMTDLLGFDRLLPMNTGVEGGESACKIARKWGYDVKKIPEGQAKIIFAEGNFWGRTMSAVSSSSDPSCYKGFGPYMPGFQLIPYNDTDALEKELQDPNVAAFMVEPIQGEAGVVIPDDGYLRKVRQLCTKYNVLWIADEVQTGLGRTGKLLAVDHEGVKPDILILGKALSGGVLPVSAVLASNSVMNVITPGTHGSTYGGNPLACAVATEAIKVLLEEKLCENAEKLGKVLVEELNKIPKNKITTVRGRGLMCAIVIHDSISAYDVCLRLRDAGLLTKTTHGQTIRLAPPLVITEQQIREGANIIRTVLESYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7T6</accession>
    <name>A0A835L7T6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7T6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="148"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="524" mass="60355" checksum="487E596B9525B3B9" modified="2021-09-29" version="1">MANRKTLNVNQIISHLEEDDDVFAADIFITPPDNWQNSDEDSGDEEFASINNLSRHQLLAEAELRVTRSSQPESRIVNELVGDEETVHSIPSTSSVSQPPQPISSLTVTQPPPKRRRVEVTRKWRFVDIPEKSEKEYCEPDFLENLENPVQFFELFFDEEVFELLRSETEKNAIQKGKHAFRITTTDIKHFIAILLLSGYNSVSRYRMYWEQRVDCSFPTVAALMSRNRFEDLLRYFHVADNNNLDPSDKFAKVRPLWKLLNARWVKYYPGDKNLSIDESMIPYYGKHGTKQHIHGKPIRFGYKSWSICTRLGYLIYGELYQGASTGNTHPELGVGASVVLDLISKLPQGSYSFYFDNFFTSLPLLEELQKMGHDGTGTIRANRTEKAPLKDPKEMKKTSRGSHHQCTDILSNITLVRYNDNNIVTVASTQCGSEPISKVKRYCDKQKKDVDQPRCFVNYNKFMGGVDRLDQNVGCYRIAIRLKRWYWQLLMFPLNVSVNNAFQLYKISPAAKKSNDIPAFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Y2</accession>
    <name>A0A835L7Y2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Y2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="23944" checksum="6BC139DB1CB0EA7B" modified="2021-09-29" version="1">MSRDGGSKRATRLTVATAIGIWLLAALLATPAYVGSYVRAFVVNPKTQFLVCYPYPKEWGDDYPRGIVLMRFLVYYSLPLAVIALFYILMARHLVLSTQNVPGEMQGTQRQMRARRKVAVTVLAFVLVFAACFLPSHVFMMWFYYCPSAQEDYNGWWHALRIIGFCLSFLNSCVNPIALYCTSGIFRKHFNRTSVGRESSIRLLNNGSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L807</accession>
    <name>A0A835L807_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000156">
        <property type="protein sequence ID" value="KAF9413524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L807"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20831">
        <property type="entry name" value="C1_dGM13116p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="148"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="547"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="624" mass="69427" checksum="E30697A717B3D69B" modified="2021-09-29" version="1">MKQGIGVELVRALDSHPPNISNVFCECDSKDDVTITCDCEATPAFQLKAFSQRGEKVEVSHYRVNVNRFRARLNVVCVTDKLTGELKCDGWPEVKVALAPVGALRPNATENDLQQTISDIVVAALRSTNLQFNLAHYPTCPRLRRYVETPGPRLPLHYDSMVTSTRPSDVHVDTKLDGWQRHAAGRQEAARKAGCVAPYCVVEMDEPPQKNQTAFKKDTINPQWEEHFLFDLSPQTAELLFEVYDRTGPPSPGGGPSQHRFLGLGLFLFIEGADIPDLGSRPVKIKESLRTVSPHGHLTTTTKTIFKQNGHDNSQLTESALRELELSPTNAANKSTLIIHSVQRLDSEGPQESDDKFDEHVNETDLPVSASPNASPGKTVRIKENGAKANGDTEQGDYVQQQNENVPPEPAPRKRRRDFFGTIKRRLGRSRTRGASLDLTDSEVENQSRIRSISAERNAHEKALSIPNRNVYSAGASPAQSGDESRTSRSEVSGFSTASARTFIHEASTLVLETIEAGIKKHYLVPLTIAQRSRWRRKGIKLHIYNEHTFIAKHLSGGTVCEVCTKTIARRLGKQGYECRDCTLKCHKHCHVKVATNCPRSTVHNMELLAIWGPYEGRKRLTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8A3</accession>
    <name>A0A835L8A3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8A3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64203" checksum="7B3C7AF9295619FB" modified="2021-09-29" version="1">MSGTPKSVAASLMQKTLERQAALARMRLRFTKNQVEQILVNCVRNNNTGPYLELVKVLREYPLNEDNFRIVFDDSLSCVVLLGREMTQYVDVVCNIEWLDRSEELVELYRKFVLNLVTAHTYHCPIVMMRLVTLFKGDGENWEDSPPSELLNKWSHIHDIIGHIVAIMPMTSDLLMHIIIEQFPYYKAGCYVNRAYIYNLIWISKYLPSLQEQIMTAVINKMISMDVNIAEYEKGKSETMFEMDIDCQDEVSVTLDYCMLEVLKWLEDERDPIMNVLCTVFERVVLPTYGIRHVQFLLLYTISINQQCADRVLEHLWTIAAGRQGMGPGALTTRKTAASHLAGLLARCVRVPNTRLIKYLKSMAEWCHSYISATQESTAACDNTKAHGAFHAICHAIFYLVAFKHHLLFMNKENVNFVESLNLPRLVTCALNPLRTCPPQVTRAFSSITRSHQVVYCQGIIEKNARHTLQSTAVQQYDEWFPYDPYNLPISGKIIWPLCIDYKDWLKEGDDETQYSSMKRKLEEDDDYLVMASPTQRLASSLSHGISPGFRTSENIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8F1</accession>
    <name>A0A835L8F1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_006605</name>
        <name evidence="6" type="ORF">HW555_003433</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000755">
        <property type="protein sequence ID" value="KAH9631613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8F1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="5">
        <location>
            <begin position="86"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9631613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="19191" checksum="D028CEA20B675581" modified="2021-09-29" version="1">MKSKAVFVYQEEQEKKRLEQLQKKAEAKALLEKEMQSIKAAPKAVPPPPKITRAQIERMKEKTIKAEPVKPVPSKVVVEEPPLEENLNRIHLDGEVAQTVDEAISILGEKSDTDRHPEKRLKAAYTAFEEANLPILKAENPTLRLSQLKQMLRKEWLKSPQNPLNMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9J3</accession>
    <name>A0A835L9J3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferin 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9J3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="448"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59058" checksum="358452B976DBD27E" modified="2021-09-29" version="1">MIINNVVTTGSPLSVPSHLSFAQYAIDKLRENSKDGDAVAVINGDTNQQITFKQILQETVNIATGLTRLGVKRGDVVALCSENRDEFMPTALAVVCCGATITTYNVLYSKDEMKHVLNISQPKLLFASELALQRHLATFKSQSSIEKIIQLNGKVAASGILEYKSVGVPTNTNEYEPVEVEGWKDVAYILYSSGTTGLPKGVMLSHLNVLYSAASFEIENPLQNVVLLTIVPWYHAYGLMSTINYILIKRKLVYLNGFNPVKYLTSIQEYKVTNLAAVPPIVVFLAKAPIVEKFDLSSINIIWCGAAPLSAETIAGALKRMKNCKGIFQAYGMTETSLTATKDIDDDKTARKPGSAGYPLNGVKAKVVDIDTRKRLGPNENGEICLKGPLIMKGYYGNAEATRDVFDEEGYLKTGDVGYYDKDGCFFIVDRLKELIKYKGHQVAPAAVESVVLEHPGVAECGVVGAPDEAVGELATAFVVKKPGATVTEKELLEFTASRLSSVSRLYGGVIFIDEIPKNPSGKILRRALKQKLLDRQKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9R6</accession>
    <name>A0A835L9R6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9R6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="669"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="913" mass="102610" checksum="52225B314D5A2CC5" modified="2021-09-29" version="1">MTFSKVCNKRPSKKPIFKKGINMYSCLLVSSFVKLRRNDSPICKRKKSSIINDKLIAKLTDKYEKKQITIMEFLEQIRPTKTKSGASTTGAKHTGGITYGPGLTVDSSVYVEQMASRDSYEKEQKRIQDLFDAALTSESSHDPFEDDGEFGSDADFQPSGEVSSSSEDEAQASQTRHKKHRTAAVSSGESTSSSSSDTDDHDELSNHVIQSSEIPVNQEPAPLVPGVFVNDEENTNVDQVTSDPPNPTNTSPRVSDIPLADESWSHTIAEIPDFNFDSSQCGITVNVDDMNGVLDFFYLAFPQNYIEYLDEDMSKSYAVSMHRNWKPKEKIRRFRPSTSSAPQAVNISGTENITTGHWPEQILSRPGTTKKFAFLKCKLTKHSRATKILALPNEHAQSDVSGKSDSDDEIPNSIPSSNSSLHENETSPTPSVDSSLVRAVFHEDDSDEDAIDTTPVVLTSNSPLKNIEDQGDPSKAKRKKPNIVVSSAKTPKKAKRFSIDYNWKRSMIFAHTATIEENDNYINIPEPEHASHLAYFHKFFSPDILDDIVEQTNLYSTQNTEAIHFIMIGNVPCEEQAFSGKLKLEDYFGIFLRVFRVTHCFSFVTVKKMSSQRRKAFTIEEKGAIICRLENGESNSCLAKEFGVGHSTISMIFKNKNRIKQSFNSNVLKPKRLRKSRQENVDQALIQWFINMRNKGIPVSGPMLQEKANGFAARFGILDFNCSASWISRFKVRHNIVAGKIVDAILMVNDAWNKMSQSTIHNCFKHAGFIESHDGLPIQISEHEFDEEDDIPLSLWSRNLNSDSLAAPEMWEEYVDIDSALLTFEEPTDENIVQNISAKEQLESDGEEEVEEAPLPTAEEALKAAELLSRFVHSNIENDNLTIAMSSIHNSIRDCFYNKMKKQKQTKITDYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9V3</accession>
    <name>A0A835L9V3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021700">
        <property type="term" value="P:developmental maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051222">
        <property type="term" value="P:positive regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000004">
        <property type="entry name" value="Kinesin-like protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000204">
        <property type="entry name" value="kinesin-like protein unc-104 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="1601"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1126"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9424591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1704" mass="190100" checksum="DEAF99D0CE3F8EC3" modified="2021-09-29" version="1">MLLITNPKAPPGSKDGAKSFNFDFSYWSHNPNDPEFSSQVMVYKDIGEEMLQHAFDGYNICIFAYGQTGAGKSYTMMGSGKDGQEGIIPQICKDLFRRIRQTTSDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPALGPYVEDLSKLAVTSYQDIYDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQQRHDQTTNLMSEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEIASKSKKSKKADFIPYRDSVLTWLLRENLGGNSKTAMIAAISPADINFDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEILKLRELLKAEGIEVEEGEENNASPQRKKSEAEVLSPKLSRAATTIAEEAVDQLQASEKLIAELNETWEEKLKRTEQIRVQREAVFAEMGLAVKEGGITVGIYSPKKTPHLVNLNEDPNLSECLIYYIKDGVTRVGTSEANVPQDIQLSGSHILSEHCIFENTDGVILLIPHRDALIYVNGREVTEPVILKSGSRVILGKNHVFRFTHPGQPREEPINKENKELTTSYTETGSTDADGKNVDWDYAQCELLEKQGIDLKAEMQKRLLALEEQFRREKEHADQQFEEQRKNYEARIDALQRQVEEQSVTMSMYSSYTPEDFHNDEDIFVNPLFETECWSAREVGLAAWAFRKWKYHQFTSLRDDLWGNAIFLKEANAISVELRKKVQFQFTLLTDTPYSPLPAELAPRDDADDEYRPSAPTVVAVEVTDTKNGATHYWTLEKLRHRLELMRQIYNMNESACAEDDAPPLVLAPPPHVAGGAAGGVVGGAAGAQPPDILHCISACAQQTRLSLANLLPSRQRLELMREMYHNEAELSPTSPDHNIESVTGGDPFYDRFPWFRLVGRSFVYLSNLLYPVPLIHKVAIVNEKGDVKGYLRVAVQAVIDAEKNNAEFAAGVKQSAKISFDDDVAPARRTKLSAVDKNNAINLDERINDVPDSNIKIEELAMGECDADSGRGDSSLASELKEEDLPEHLTLGKEFTFRVTVLQAHSVSTDYADVFCQFNFLHRNEDAFSTEPVKNAGKNTPLGFYHVQNITVPVTKSFVEYIKTQPIVFEVFGHYQQHPLHKDAKQDGGAGVVGGRTPPRRMLPPSIPISAPVRSPKWGAAAVAAPCCSSHLHSKHDLLVWFEICELAPSGEYVPAVVEHSDELPCRGLFLLHQGIQRRIRITILHEPSQDLQWTDVRELVVGRIRNSPEANEDTTDGDEDGALSLGLFPGERPTLDDRAVFRFEAAWDSSLHGSPLLNRVSANGEVVYITLSAYLEVDNCSRPAIITKDLSLVVVGREARTGRSLRRALFGSRAARADHITGVYELSLHRALEPGVQRRQRRVLDTSGTYVRGEENLHGWRPRGDSLIFDHQWELEKMTRLEQVGRTRHLLALRERLRHGHENTVAPNDFTKTEKEVNNMAAKAAAECARDESVYEPWDMSPREKELATKYIKLIQGRIGSSGKEVEAAASPATPVDEGVSADISTPSLLSSIHSASSFDRLCSPERGLLEKSMAGWAGGAGPGGQLGALGALGGLAAPGALYVPDCEEVRVSAAVARRGHLNVLQHGTHGWKKRWLVVRRPYVFIYRDERDPIERAVINLANAHVEYSEDQEQMVRMPNTFSVVSKERGYLLQTLGDKEVHDWLYAINPLLAGQIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAW3</accession>
    <name>A0A835LAW3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein asunder</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell cycle regulator Mat89Bb</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Set apart in position or space protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_005691</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="17">Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13, IntS14 and IntS15. The core complex associates with protein phosphatase 2A subunits mts/PP2A and Pp2A-29B, to form the Integrator-PP2A (INTAC) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="769"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9417180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="840" mass="92422" checksum="A2B7433CD93F0D97" modified="2021-09-29" version="1">MFPINHKTIFVLDHTPYFGISSDNPIDFDVPKNRGYLPVPPICKSLWTCSVEAAVEYCRIVWDLFPEGKLVRFVVSDNTAHMLNTWAATQQNLTHLLNGLCLVGPVRRGAGGDVEGLVAAIEALAEPSPEQANRPTERHFQNRGRVICITSARDNDSIKNLKDIAHNTIVQINKKASMVQPPTTSDSANTTPQPLVIHYCHIVIINVTPENAETEVTNQPLAEIAGGQIGVEVIVSRASALANLLGRLVLPHYKLATTTVTGIPMKEEQNASSSANYDVEIIHAADAHAGLRASQTAAEALESVVLRWWTPRGAEGGASGCCGALWRVTPADVASRPSACLVNFLLNGRSVTLEVPKHMDFKNRNKRNDAVRDIASVFNIASSEIERKLKNLSSHYFREKRKYEESKRSGSGRDDVQLPKWFAYKALSFLNDKNAPVPTLNSLTPSSSQDNITSQTTLLSTRTSRKRNIEREPEVDEALQLLREITSNARQRDDAAIFADYISSKLRKMDHYTMCTVQHQIQNIVYEAEMRMGSMNFDTNNTTQPLRYQNVLPGYFTGRPTTKGGGRSASHVLAAQGGELWIGALGGRTPYDDPPALSEGAGGRVTDYRIKEFGALMQQNRLYPLRGAGANGRARARLQRHTTYWPLTISSTLIFNLGSVLEPLTRLVVQETLTDEEVETCRNVLLSLLAMESRHEFPTAQLPSNMRGKSVGRREEQWRQVWGELEALVRAHAAAPQHRALLRVLLDCRAHNHTSDSESRATVIRATTDSPLSPVGAGNGSSGNGSSGNGSDVWAPRNVLDALLGAPRPARRPDFAGRMAAGTRIATLYPQLQQDVETPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDA6</accession>
    <name>A0A835LDA6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">coq7</name>
        <name evidence="9" type="ORF">HW555_003396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDA6"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="198" mass="22211" checksum="E886509C9C285F4E" modified="2021-09-29" version="1">MLRKPILQQIRCAHSSVSASGRPYWKKNPHLDQIIRVDHAGELGADRIYAGQMAVLGRTAEGPLIQHMWDQEKKHRAKFEELINEYRVRPTALTPIWNVAGFVLGAGSALLGKEAAMACTVAVETVIVDHYNDQLRTLMEDPNIDKEILETITKFRDEEQEHHDTGIDHGAEQAPFYRAMTEVIKAGCKCAIAISKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDF0</accession>
    <name>A0A835LDF0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="320"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="498" mass="55227" checksum="8CEF7A9D870EFD24" modified="2021-09-29" version="1">MTVFHLRDIRWERPRFLSKSFLAFVTFNFISYSLLAAEVLTTNVAGTSPKEKSFYQHVFNGCYAVLLFIVVTFFLIYGVEVYFKLRGEFLKETKVCTIISPRPGPSSADDGDDVQDTLVTKQVRIGIQTDLAADGSVDPRSVDVSQLHQSRFGLISQALMLILIAGFLASETLSEFWKTKVPVVSRNWHDLVFRLAEIGVALWFPCVLWNSMAPERLWLLNPRRLLARQLDDARLADLLAQHHDAKNLVEKHRMSWMERAQLVVRVVSLCRCLVARTILNVFRPQLALRDSAEDASDTVLDLPARSPAKRQNVETDSLVGSVGSARDCWICYDSSRSEPLIRPCRCTGDVSAVHHDCLSRWLVESAASPDGLKCKVVVWERGFTVAHWARTALAVACMCAAGAAAWVCVQLAASPVARVLAAGAALLVCYVAIRFLGMNTVSAYQRAKVSSLRILTEPLTEITGQNDQGQLSTISNTVTVEIASKGVLERALKGEVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGE2</accession>
    <name>A0A835LGE2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="68" mass="7730" checksum="649626C503E8F7C6" modified="2021-09-29" version="1">MNTLRGQSDCPELVAQLVRLFVPTVLNHPYTLGHAGTPYWLSRKWLRYPDHVTKESLACLMIGSTFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835FZW7</accession>
    <name>A0A835FZW7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Codanin-1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000969">
        <property type="protein sequence ID" value="KAF9404480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835FZW7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040031">
        <property type="entry name" value="Codanin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028171">
        <property type="entry name" value="Codanin-1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28678">
        <property type="entry name" value="CODANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28678:SF1">
        <property type="entry name" value="CODANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15296">
        <property type="entry name" value="Codanin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Codanin-1 C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="893" mass="100428" checksum="9438F7761927EDC1" modified="2021-09-29" version="1" fragment="single">ENKKVRSFYPDLAKFLLNCYGLRCEAENNQDKSRQTESQSNGVVCFNSETDNIDNFPSMLSFQTFKKQRDMWYQDTQSGGSRSSLRGRVKTLLCTGAGPCNLAHLANLFTSHMYQHCLPASKQESKLSKLQRRLTCPNAPESNRLPQFSQQEMFYKDFIINAENESFRVHLRDAIASEICVLDATHIASDDRSNSNFDITKEYLALSKKLGLLAKFLGLLASLPYTQLVVDPSNKNTVAKVICREVNYSTPKEKVLANDLALRNYSQPALDLLGILKNAQENGRLSISLPWIVHYLSMLDYTSLRITYYQNLLKILFDIHTNRLKLHNTNLKKNTVIYLKSILGWLFDLPHFPQELFYENRLNVSVGSDLNVDACDLVDESVIIELCPHLKDLNVLLSTCRVSQEQKDMASYRHITPVSLTLNPEDRIKNKEKELQARLEEELLKSQPSSTRRVLELVIERVTSACVRELSAHTLTEVRERAGRAVAKMVSSYQGDQASLLPAAQQIYTDHLQLLRTKALESGRSSIQSRSEAAVAALLASAPAPLVTLVVRAAVTRLGKWVNDNWTVLCKDVEAELKTLIALGDLAITTCHKTTVDVSAMTTPGAQFTAQHVSAAACVINLKGSEAPSLARVLAMCALACSPTNMFIRPPTQRAILQLSVDLCVVFVSRKPKEVNESFLSKLHAIWNVCCPDRKRSPPQEITLPERREELSPQFRNFEDEERAPTPISDEEIPTKIVIINPNPETSEKLTSNSEKLPTNSENSEKLPRKSGSQGQESDDSDVNLEFFDRILCPRNIMLLSDGKCVDVWEAMATVLVFLLKHDYLSEDSLTEQCLAVYRQDWSQSVLESLSTCMKSVSARWSRSSTGKFTLFLDFLAEYCGDMDYDPSDPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G125</accession>
    <name>A0A835G125_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001016">
        <property type="protein sequence ID" value="KAF9404320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G125"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="162"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="339" mass="38530" checksum="3303477EB23841A2" modified="2021-09-29" version="1">MKEIPFHYDQVGSFLRPEPLKKARAEFQNQTISAAELKKVEDQTIIDLITKQVNAGLRAVTDGEFRRSWWHLDFLWGLNGVEVTTPEHGYQFNKVETRAASYNVADKITYNAEHPFFEAFTFLKEHTPAGIIPKVTIPSPTLLFNRKSDSFSYESYSNEEVFISDLAAAYQQTIRKFYDLGCRYLQLDDTSWGMYTGFIENAKSDDEIKHWHRQCDAGVSVINQLLAGLPDDLTITMHVCRGNYKSDWAIAGPYDHVADYLAQLNIDGYFLEYDDNRSGGFEPLAKIYQQGPSKKVVLGLVTSKFPELESKESLIARITEATTYVPLENLCLSPQCGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G143</accession>
    <name>A0A835G143_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable transcriptional regulator ycf27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">OmpR-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_014366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001001">
        <property type="protein sequence ID" value="KAF9404378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G143"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000001">
        <property type="entry name" value="DNA-binding response regulator PhoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000018">
        <property type="entry name" value="DNA-binding response regulator ResD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="REGULATOR OF RPOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111:SF10">
        <property type="entry name" value="STAGE 0 SPORULATION PROTEIN A HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="C-terminal effector domain of the bipartite response regulators"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9404378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="26614" checksum="4EADB7120E753D73" modified="2021-09-29" version="1">MEEIKDMKILVADDDKEIVELLSIYIHNEGYEVIKAYDGKEALSKIRTISDIDLLILDIMMPIMDGMQVVKELRKESQIPIIMLTAKTTDMDKIKGLVAGADDYVTKPFNPLEVMARVKSILRRSQMQQKADEPDILEVGSLIINKDSHEVKTIEGTEIQLTALEFGILYLLASHPNRVFSADEIFERVWQQESIVSAKTVMVHVSHLRDKIEEATGGEKVIQTVWGVGYKIDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1H3</accession>
    <name>A0A835G1H3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyl hydrolase family 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001030">
        <property type="protein sequence ID" value="KAF9404270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1H3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05296">
        <property type="entry name" value="GH4_P_beta_glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092:SF5">
        <property type="entry name" value="6-PHOSPHO-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="6-PHOSPHO-BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 4 C-terminal" evidence="8">
        <location>
            <begin position="212"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9404270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="478" mass="53478" checksum="0B0224EAC5503B45" modified="2021-09-29" version="1">MSERILNKKSGGKHMTREALKIATIGGGSSYTPELIEGYIKRKDELPIKEIWLVDIEAGKEKLETVGAMAKRMVQAAGLDWEVHLTLDRRAALKDADFVSTQFRVGLLDARIKDERIPLSHGVLGQETNGAGGMFKAFRTIPVILGIIEDMKELCPDAWLVNFTNPAGMVTEAAIKHGGWKKTAGLCNVPIGHRKQAAEKLGIPEDDLFFKFAGINHFHWHRVWDKAGNERTQELIDLIYGPQEDSESHLKNIHNAPFHYEQIKDLGLLPCGYHRYYYIEDEMLKHSIEEFEKGETRAQVVKETEARLFELYKDPNLDYKPKELEQRGGTHYSDAACELIASIHNDKRTDMVVSTENNGTITDLPYDCVVEVSGPVTAHGHEPYNWGSFPPAARGIIQVMKGMEETVIRAAIDGDYGAALHAFTINPLVPGGAMAKTLLDELLIAHKDHLPNFSEAIVKIENEQPETVAYVTELMKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G273</accession>
    <name>A0A835G273_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000573">
        <property type="protein sequence ID" value="KAF9406588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G273"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="283"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="811" mass="89918" checksum="57D2B3D8AC124B78" modified="2021-09-29" version="1">MDSFFSLFDPSEGSQNKPKNKKRHKPEQDTVKKKPDAPKGRRRGRKSAVKNETLPEESSFLCEPDLSTDLLVKDVSYIENFIEINKKDDGRKCRRKKNKISPLKDLPNQAWGESNTENNVETKNWNNQLLVQKICDENVGKNVNDLKNEMKIKNKRNEVSTIEKFRDREVYNVIDKLEKVILKDDMYLAGDFDTNDLENDFFYSSDDLEDFIDDSTSEPDDSGDEVYGSLPPEPRFGNVEYKLQLVSLCERRFQHLVTQLKWRLRSGGGSAVYVLGLPDPKQSVELRVAVMGANEAGKSTLIGVLTQGELDNGRGSARLNMFRHLHEVKSGRTSSLSHEILGFDAQGNVVNYGCSELMTAERIGERSAKLVSFLDLAGHSKYQRTTLHGLTGYSPHYAMLVISATAGITPITEEHIGLLSALDLPFFAVISKCELAATAVKTLTARLAELLAASNKKPLLITDENLARNCVAPQKLIIDSLDHTKSESITESSVIPVFPVSSVRGVGLRALHAYLLALRPPQPASSHTHDEETCEFQIDEIFHVGDNSGPVVGGLLARGQLREGDSVIIGPLEDGSFASTIVRSIYRNRAPCGSVRAGQCASIGLAAGAAPRPGMVLLAPPRRAPRRPAFGACAPGHCKQANQLKQLIEQNLCEKAKHRKSVRRKNKNLLRDIDSEDCLTKDLGMDSNSYDDEDNEGAFDDCMCADKVLLEDPNDPRGCIYFQASVHVLRHSTVIYPGFQCTVHVGNVRQTAIIEGIMSLHNVLRADETASVLFRFVRCPEYLVRGRRLLFTAGLGTRGIGRITQVFPYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2J9</accession>
    <name>A0A835G2J9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000683">
        <property type="protein sequence ID" value="KAF9405783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2J9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048998">
        <property type="entry name" value="STPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21107">
        <property type="entry name" value="STPRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STPR" evidence="2">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="277"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="921" mass="105514" checksum="CF70DBD2CE100E19" modified="2021-09-29" version="1">MKNYTNLRLRQETLEQREFRMRLDNESPEQRVHRLGLIQNRLDNESPEQRAHRLGLIQNRLDNESPEQRAHRLGLIQNRLDNESPEQRVHRLGLIQNRLDNESPEQRAHRLGLIQNRLDNESPEQRAHRLGLIQNMDWTTKVHRLGLIQNRLDNESPEQRAHRLCLIQNRLDNESPEQRAHRLGIIHNRLANESAQEREKRLTTMRQSSQRQRSMIECNFINTINQYAEEPCTVCKKILYPKQKMVLVPTRFEFLTQEVAVLEKNIVCSRCSTTIKKRKVPSQAYWNNMDVMSLPPELADLTDVEQRLVTTTKSFSQSWCRGQVILFAQDVVEAAEQLPLPLAVAGIVVVVETRDNLPNHKQFQVDIRKIKVALINTKYRDVRPNFANIINYDISQIIEVSESNVNEINNENNVDVNHIEVVNKQQISKFISLNNNTSILRGSFHQGSDRLGSSGRQCTAIAAVACVACYKSDPTAWTVSDLDYILIIGDKFYRQCLAAKPEPDPAEINSDYLGATELLPQITFQGSCVNLNIAHDLSINGHFSRDQEGYPNLENGIASFFDNNYTCGILTANFISVCIAYKNLSYWLIDSHARGPKGHKGRTGGVSCCLRFENSRQIAALLRCNLKATGLLEYMLNIYSITPVFVVESGGHIRIESQHSERNLNVIKKVEDFSSKSTTFLDLHFREVIKNLSGDRRLILTTSMLYDIDENIPNLDSVIESDNRNLNENRVTDIHRKTAPLIEILNEKEEWKNCVDGKNGFGESRNISITALDYFQARVMNNETRFQKVDYLVFALSVVGYFRAKASVSTHRHSATCYKDPNNHSCRFGFPRPISNESKCLESDKTLANQGRSESEVMIYNYNLVLLELWQANMDIQPCGNVTAVAYYIAKYASKCEPNDCGDVVREVVQKAKRHSNDVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2T6</accession>
    <name>A0A835G2T6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000717">
        <property type="protein sequence ID" value="KAF9405570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2T6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="230" mass="24322" checksum="3D5CDAA3F24C851D" modified="2021-09-29" version="1" fragment="single">GGGRRECSEAAGCACGGRAVPPAPPAHHPLHALDQMPPPLLSHFSIARSNPLYTEEEEQEVVIIVDSLDEVPEGEAPEPPRTPRRAPSTSSGYGSGGGSHGRVSPNLPKNEQFEPPARRLSDSDKNDGSHTTSDSDASPICTLSRSLKEDIRSCLGVCRWEKDVNDVVEAAVRGAGGISAARARLHAALLALHEPPPRLPNRGPSLPYCGPGVRPGDVTMMPKNTEMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2W0</accession>
    <name>A0A835G2W0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="7">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000709">
        <property type="protein sequence ID" value="KAF9405623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2W0"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="37768" checksum="98FDC57FFAB6435E" modified="2021-09-29" version="1" fragment="single">NITTHATLLGRYLCAGNTDVYNNLDKFSVDEEAGKRQIYHRYCMERAAAHMTHIFTTVPDITGYEAEHLLKRKADIITPNGLNVKKFSALHEFQNLHALAKDKINEFARGHFYGHFNFDLDKTLYFFIAGRYEFGNKGADIFIEALARLNHYLKSSGSDMTVVAFMIFPAKTNNFNVESLRGHAVTKALRDTINDIQQKIGKRMYDICLSGHLPDASDLLHKEDTVRLKRCIYSLQRDGLPPITTHNVVDDWSDPVLNSIRRCELFNTVNDKVKVIFHPEFLTSTNPLFGLDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSITTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2W6</accession>
    <name>A0A835G2W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_014106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000855">
        <property type="protein sequence ID" value="KAF9404913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2W6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000032">
        <property type="entry name" value="Export ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42798:SF2">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN MG467-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42798">
        <property type="entry name" value="LIPOPROTEIN-RELEASING SYSTEM ATP-BINDING PROTEIN LOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9404913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="233" mass="25437" checksum="D6FE902208E9988C" modified="2021-09-29" version="1">MAYINVIDEYKRYHMGDTTIAANDGISFSVEKGEVAVILGPSGAGKSTVLNILGGMDSCDEGEIVIDGTDIAKYNEKQLTTYRRNDVGFVFQFYNLVPNLTAKENVELASQIVSDALDPEDVLKSVGLSERLDNFPAQLSGGEQQRVTIARAIAKRPKLLLCDEPTGALDYETGKQILTILQDTAHNTGTTVLIITHNSAIAPMADRVIRINDAKVRNVTINDEPKPVAEIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3H1</accession>
    <name>A0A835G3H1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000825">
        <property type="protein sequence ID" value="KAF9405052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3H1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27723" checksum="88BA96455EA93AF5" modified="2021-09-29" version="1">MSQITDIITVHKNVQESLLKRMGDIEAQIQSAGSSKDTVARIAEEFRTFRELVFDMLKLLRSQVTECCRNIDGLEMRNRRKAVIFQGIPEKDKEDCSQVTLQVINAKLGQDFPMSALKVCHRLGVHNKNHHRPILVRFSSVDYKASVWRAKTRLQGTKISVKEFLTRPRQEVFVRARQHFGMRACWTQDGNIFLKASDGSKHRIICMEELSPLLDKYPSVQSVSQKAAGGGAEAHTVSLKSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3I2</accession>
    <name>A0A835G3I2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Elongin 18 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SIII p18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_013150</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (either CUL2 or CUL5), a catalytic subunit (either RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1 or RAB40C. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Elongin B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000582">
        <property type="protein sequence ID" value="KAF9406507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3I2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000108">
        <property type="entry name" value="Elongin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="17">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9406507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="16889" checksum="ECDE7B837E182AD0" modified="2021-09-29" version="1">MDVFLMIRRKKLTIFTDAKDTTTVLELKKMIEGILKVTPVCQMLFNKDSQLMEDDKTLAEYGLTSATAKAQCPAPIGLALRKENGEFEALDLTPYSSPPDLPDVMKSQETNGQEQVCTKWINTKQLSCGLDETDASTNLASQQFCNIPSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3K7</accession>
    <name>A0A835G3K7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000709">
        <property type="protein sequence ID" value="KAF9405620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3K7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032787044" description="Citrate transporter-like domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="199" mass="21884" checksum="41AE327FAA97DEA6" modified="2021-09-29" version="1">MLLMRPHRVYLGWTALLGALLLLTLADHEDLESVLHRVEWSTLLFFAALFVLMEALSKLGLIGYIGGWTEALILRVDESVRLAVAFILMVWVSGITSAFVDNVPLTSMMVRVVTSLGTHPTLNLPIEPLIWVLSFGVCLGGNGTLIGASSNVVCVGLAEQHGYKITFMQFFKIGFPVMIGHLVVATAYLLVCHCVFSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G464</accession>
    <name>A0A835G464_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G464"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8424" checksum="39CB39C788B4E6E1" modified="2021-09-29" version="1">MIITTKATIATNNKLEKAGNAFAQEISAVTGDMRRPKKVRLKWENLKKSARKLKKRRKLSEEVQRAQRDKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4U5</accession>
    <name>A0A835G4U5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_013002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000557">
        <property type="protein sequence ID" value="KAF9406715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4U5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF77">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032558991" description="Peptidoglycan-recognition protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="11">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="10">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="69"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9406715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="212" mass="23149" checksum="BAFC3F991AA59BFB" modified="2021-09-29" version="1">MTSVRVIVCVAFISVAVCASPRFITKNNAYSFPFVSRDEWGAEISSDARPLNHPVPFVVLHHTYIPGACFDKEDCSAKMRSMQRYHKSLNWGDIGYNFCIGSDGNAYEGRGFDNVGIHATVANRHSIGICVIGDWRVETPPAETLATTKALIAEGVKLGKISPDYKLIGHNQVSATECPGTAFYKEFSTWDHYSPGNPDFSGLSVPVAAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G569</accession>
    <name>A0A835G569_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000589">
        <property type="protein sequence ID" value="KAF9406456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G569"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33776" checksum="437CBD0FCFD297EF" modified="2021-09-29" version="1">MPKVVKSAGREMILKVKEFCEAEQRNNGVLIPINNVRKRVAAMTGVSEKTVSRIIQEGKMAASTSKKIVTPGKSRPRRKSVNLDSFDLCAIRQKIHQFYIVKKELPTLNKLLAVLKEDINFDGSRATLHRILQSIGFKYKRCQSKRKILMERYDITAWRARYIEKMRKNRNVEKRPVVFLDETYIHNTYHAKNCWQSKEEPGLFTSESAGNSFASVTAEDWFKQCKHVEHLEDEYFKNDGLIDEEMDRFIISTASDSETESDHDSDINVDNSDSDCSMSGITPIDDHNYTIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5B9</accession>
    <name>A0A835G5B9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5B9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="582" mass="66555" checksum="0261E2183B9D068B" modified="2021-09-29" version="1">MIRKPNIQGRFYLSQNEEDTIYLDNCRVPQHHIEGIRFLYKQFKRKRNGVIINDPLGFGRNIQITLFLKAVHPLLSRPVLILCEEGSENDWYERFFTWTDLSDDVVIETKNPMLKKAVIINTMVNLHLFCARDWSIIIVDGDKVTSTNPLLKLPLRSSFKIWNTQINLKENLDRFEEVYKWMYPQESFDKNYFIANPDSAVDVIEKSILLDSFLEDILIRREDLNSSFEKYQREVMMPPPKTTTIMPSIHPTLNSPNTTITPVVGPAPPPPPPAPTPTVIITKKNKDATGTKIKRSKTKIDADTANKPYEPILPITTSITKVVSETPKTFETFDTNEDFSIENYKRKSKDNIVNNDKPIQIIEIDNRCDMKSYYEQGAESKSADKLEEMDTLVFGHDTFISKVSDHYKPGHAASDKKETEPHTILTCKPIGEQSTHKLYTDNKICSSTVTSSSRKIYDPSHHDPERDKKNDRASLLARDVDTAKVNLEELNKEMRDLGTRDNPDKVSKRQKTDSAPKSVITFEQYKTKSSLSNTQVSASGILGSGTEQVTNSLKRNNIDDKMKECEEKVSKKFKGSFLDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5M7</accession>
    <name>A0A835G5M7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000476">
        <property type="protein sequence ID" value="KAF9407391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5M7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8323" checksum="917E05747B4AD67B" modified="2021-09-29" version="1">MTEAGFVKAQSDNLPKIDAFMMTAYFASNPDFTSAEIRGVKAARSTRESYGDSAVGYVQVKRDGDICVVKAQMDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5S3</accession>
    <name>A0A835G5S3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000574">
        <property type="protein sequence ID" value="KAF9406578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5S3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36253" checksum="CA555A7149F0E92F" modified="2021-09-29" version="1">MEYETDCGEDLWASFTWHRRSYLVCIVYIKPSASDAEYMSWFCKTESFLNNFKGFVLIMGDLNLKSASINVANYYCYFLSFCSLVDKNVILNHHGGMLDVVLVREGSHGVCVSSADGIVQPDAYHPPMEVERSKCHDDYKTYSNLRNTLKSRVEGAYRSYITRVESNIKLNPREFWRHISSLRSKGGFEPQVNFRGESFTGAAAAEAFAKFFASVFLTDVPRLNADSVNSFDVNHNSNYVNIFHITSEDVINGINKLKTSTKIYNKLASVVKVLCGVPMADTVGTLARASRPARAALWRPRTVTALILYQLHSLLMIEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G665</accession>
    <name>A0A835G665_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000432">
        <property type="protein sequence ID" value="KAF9407823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G665"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF5">
        <property type="entry name" value="FI18040P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="115"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="26120" checksum="85EEB7D05CDE078E" modified="2021-09-29" version="1">MSVWLTLVKSSHWGLPCNPRPVFLQVRNSRTESTEDDKRSDDSRPLSHASDFSRDNILSLSSAPRRSRRGVAPYSESQRPLTRYLPVDRDDFDLRRHVESAGHQIEVCPYLTVTPTSCRGYLHKLGAKFHTWSKRWFVFDRETKTFVYYWDKSEKKPRGGAYFQVIEEVYLDHGNTSKSPNPLTTFIVKTRQRRYYLMAPSGEAARIWIDVIFTGAQGYTEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6H7</accession>
    <name>A0A835G6H7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000282">
        <property type="protein sequence ID" value="KAF9410030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6H7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="16825" checksum="DA98FE022E6FAC21" modified="2021-09-29" version="1">MLLVIRSVVDRPCSRTCTCNRTRLKQLKLFILYSRALRSEGSIRKRGCPVYVEWEGVVGRRARANLLHKAVPLPRAAHKIALGGAAQPLSANVSAIAFAAPAQLKRRLGGPRAPAAPGAPPAEPAPSTSGAAAAPAPEDAAPTNGAVRRRAPDTLPMEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6I5</accession>
    <name>A0A835G6I5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase SUV3 homolog, mitochondrial</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_012753</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000504">
        <property type="protein sequence ID" value="KAF9407119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6I5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000446">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041453">
        <property type="entry name" value="Suv3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18114">
        <property type="entry name" value="Suv3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="357"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9407119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="723" mass="81495" checksum="420104EBBD746F9D" modified="2021-09-29" version="1">MYKGFTRILSLHCADKIQPCVPPIIRNNVITRKGGHNIGYIFLRTKRHDRGPSALFVPVPVKPNPDDINIGAEITGRLKKQDLLKILNKFYQKPEVRVLASENGLDEQLLHQAFLSFRRHCLEHDLPPDLHIIISDIIQGAGHVDDLFPYFLRHARLAFPHLDCLDDLKKISDLRTPANWYPEARAINRKIIFHAGPTNSGKTYHAMERFLNSKSGVYCGPLKLLATEIYHKSNKHGTPCDLITGEERRHASLYTSLTGTDEKNIEVPDDHNLQLNATELTASNHVACTVEMTSLNNRYEVAIIDEIQMIGDRGRGWAWTRAILGLQADEIHLCGEAGAIGLIEEICNTTGEELEVRTYKRLTELKVEDTALGSLDNVKPGDCIVCFNKNDIYSVSRAIEQRGQEVAVIYGSLPPGTKLAQANKFNDPNSSCKVMVATDAIGLGINLSIRRIIFYSLIKPVVNEDGDKEMDVISISQALQIAGRAGRYGSAWETGYVTTYKPEDLATLKKLLANSPDPVTQAGLHPTAEQMELYAYHLPHASLSSLMDIFVHLCTVDVTLYFMCNTEAFKFLAEMIQHVPLPLRARYVFCCAPINNKLPFVCATFLKMVRQYSRNEPLTKNWMCNAVDWPLPAPKTIMDLVHLESVFDVLELYLWLSYRFADMFPDVKLVRDMELELDAIIQQGIFQITRLLRNSEQVLRDDPQIQALNNKRAIRVGSSHTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6M5</accession>
    <name>A0A835G6M5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000359">
        <property type="protein sequence ID" value="KAF9408823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6M5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000041">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000002">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="252" mass="28791" checksum="82BF0066A781EC88" modified="2021-09-29" version="1">MPRCSKRTRSGAPANGGEVLPGATAIDDHHHHKRSRNSSSRRHSKSEDTSFSVKKCLAWFKEYTTASEPDVLGPEGMEKFCQDIGVDPENVVMLVIAYKMGAKQMGFFTQEEWLKGLTELQCDSAHKLQNKLEYLRSLLNDPYIFKAIYRYSYDFARDKDQRSLETGTARALLGVLLPRWALRPALSDFLARERRYRVVNRDQWCNILEFSRTVDTQLNSYDADGAWPVMLDEFVEWLRAERAGDAAMPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6P5</accession>
    <name>A0A835G6P5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich melanocyte differentiation-associated protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000274">
        <property type="protein sequence ID" value="KAF9410180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6P5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000695">
        <property type="entry name" value="leucine-rich melanocyte differentiation-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF2">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37480" checksum="755894BB93440936" modified="2021-09-29" version="1">MSTYLDSVTKNFSENLSNVLNAGAILITFFETCLFPWAIYKLIVVVTKYGSVFTWWRRTDDAKKSVKSQLKYKIQLLTMEKYVLPDSKRVEQISHVSVIIEEGNVQLSYCGQECRRIPPALQKMYGNKVKCLDLSYNCIETLKGLEQFSRLEELILDNNKLGDAVSFPYLSNLKTLSLNNNEITDLEELVNKISKHFPALTYLSLLSNKACPNQLSDVDKDDSDYQRYRYYVIYMLPNLRFLDSRRVSSAERKEAATRGEFMRVRRPPSHEFSTPFTPSLQPKPAMRPLPLDLGSLGKHRGAYGKCSYKYTGKHSEGNRFILNSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8B3</accession>
    <name>A0A835G8B3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arf-GAP with dual PH domain-containing protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000231">
        <property type="protein sequence ID" value="KAF9411246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8B3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08832">
        <property type="entry name" value="ArfGap_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000011">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF2">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="129"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="282"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49692" checksum="4721D67E7DCDEFFC" modified="2021-09-29" version="1">MVDHNQKLLQELQKKSGNNVCADCGNLDPDWASYNLGIFICMRCASIHRGMGAHISKVKHLKLDRWEDSQVQRMKEVGNNAAKNKYEERVPPCYRRPNKNDPQVLIEQWIRAKYEREEFCHPERQSYLSGTMEGFLMKRGKEDSRYQLRKFVLSENEDTLKYHPATDGCGRTTGCLDRLIDRLRVKNFGPLRYHVRENKEPKGVLKLSELNVAFAPSKIGHMNSMQLTFMKDGSTRHIYVYHEDPEVISNWYTAIRCAQLHLLQVAFPSMPQSDLVLRLPKDFAREGWLWKTGPRPSDAHRRRWFTLDNRKLMYHDEPLDAYPKGEIFVGHESNGYCIKVSNTGNGCKDARFPFQLVTPDRTYCLAATTHEDRDGWLAVIQQTIKRPLTPQDSTSLMQAGPRRTLWSKNFSSPRRLLLPQQAALESYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Q1</accession>
    <name>A0A835G9Q1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_009005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Q1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF37">
        <property type="entry name" value="ODORANT RECEPTOR 46A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9412481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="389" mass="44965" checksum="161625E57C2469B0" modified="2021-09-29" version="1">MPSDQSKMFDNSFILLKVFGIWPGIIPSRYYKFYSFFYLLVTFVCYNILLTLNLLYTPRKIELLLREVIFYFTEITVASKILTILLMRDKIIEALNLIDCDVFVGDYEKKGGLYKTNMGFKLGWKSYLILSNIAYSSQVVAPVFLDILRGTKTELPICKYYFLSDEVRESHFLFWFLYQSCGMYGHMMYNVNIDSIIAGLLLIAIAQLKLLGNNLTNLKLSDEERKLSKDIQDKIQITRFNKMLRHYEVILNYCDTTQDILSATLFFQFSVASIIICVVMCGLLLPSSTETKVFLVMYLFTMTLQIFVPGFLGTQLTHASEGLITAAYNSEWIPRNESYKSSLKLFRERISRPVVISGLKMFPLSLLSFTSIMKTAYSFFTLIRNVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Z7</accession>
    <name>A0A835G9Z7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_010487</name>
        <name evidence="7" type="ORF">HW555_008889</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000207">
        <property type="protein sequence ID" value="KAH9641975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Z7"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9641975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="576" mass="65911" checksum="4836F7B57BBFE298" modified="2021-09-29" version="1">MSSLIELRPNRRLLDHDFEGYKLNLQALPHFSHQLLEPVDKVYPDEVQYSFVHAKLFALHNHLVLDYWDYVLNFYYIDREQKIRRVCFDNTNQSFHNQVVYDVPAHVERRSGHFNLCLSFPSESVAVVSDGTGYLHIVDTGARNRPSGRNQEWQTVQSSLILGEGKYFIIMDSRMQEKDNIETLHCLLQSVEQNESHFDSVLTWVTFDKEDQGWKQMSFRQVQGKGIVHYAAIETSCTALYIASDNTFKFTLDSEKEIVKPSMETPRTIIYTWLQTTEDITITLKLEPNFNKTLLIVSVTPLQIKVTYAGKTFVDGKLNHKVDSELTTWNVQENGQVDLLLTKSESMLWDNLVEGGDPNGEQIMDASLVEEAHRRLAHLCAETEVMADSAVPGLSTQELEECDAASEEDTVLVRLDATNHNVTHRAPLSVHQYLFSIKIETQEVPALALRHDVDACIWQPYAQLVNSNTWPVKHQGSLSAFGYVQSSKQNRKFVTCPPNFSYSVVCEATRHIFIYQTNSNQDSQLRKRTGGTMRTIKIGQQHVFNIDKYGEVLGINATNEYLFILTENHLVAIQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAI3</accession>
    <name>A0A835GAI3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000287">
        <property type="protein sequence ID" value="KAF9409959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13854" checksum="DD99142AC680E2E0" modified="2021-09-29" version="1">MYEGNYPPRRDFGSSKWLSNRAMDVWYGNKTMIEVLSSEFSNILMKLTGGRGGRSALQFHNSTDSINSTVALQNETDIIFPMVNVDSFMNDSNKKTQLIHLIPMRNSTVFKLLAPILEVPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDB8</accession>
    <name>A0A835GDB8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prohormone-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000155">
        <property type="protein sequence ID" value="KAF9413565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDB8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053103">
        <property type="entry name" value="IDLSRF-like_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967:SF0">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17293" checksum="312EAF1810AB448C" modified="2021-09-29" version="1" fragment="single">EYCHPYEPFKCPVDGNCISIQYLCDGAPDCIDGYDEDSKLCTAAKRPPVEETASFLQSLLASHGPNYLEKLFGSKARDALEPLGGVEKVAIALSESQTIEDFGAALHLMRSDLEHLRSVFMAVENGDLGMLKSLGIKDSELGDVKFFLEKLVNTGFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDI3</accession>
    <name>A0A835GDI3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13929" checksum="86AE1B5A678616A5" modified="2021-09-29" version="1">MPYDYFCPTVKLRLSSRTCKTCGLYHASVKSLNRHIEKIHKKVNTPTEGKVTPVRVAARRANELMCIIQNLEHQDVEWLDESDVDIPKSDENEQTHNTEQQSNVIDNLESWIQVSWTEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDP6</accession>
    <name>A0A835GDP6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDP6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9412397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="186" mass="20493" checksum="16C6DD07BC057D09" modified="2021-09-29" version="1">MNHMDHMDHMDHSQHPGHDGHEGHDMHDDPCAHAGHGHAMVFHAGVCQEILFSGWMTTNALELFGSAVAIFFAGVLYEGLNTSVRPCMRGPRLLPGDSRVNITKSECGANGPCGGTAVVKYTMFSSGHVIQTLLHFLQSTASYTLMLVFMTYNVWLCIALVLGLAVGYFFFGWRKNTVVDVNEHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE85</accession>
    <name>A0A835GE85_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STING ER exit protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_017574</name>
        <name evidence="5" type="ORF">HW555_006829</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000108">
        <property type="protein sequence ID" value="KAF9415558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000436">
        <property type="protein sequence ID" value="KAH9637796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE85"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="4">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9637796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24464" checksum="E4A002557BB183FD" modified="2021-09-29" version="1">MPKVVSRSIVCSDTKDQEEYNETKPLHIYYCLCGQMSLILDCTIDRLPLRPTDLARVIDGSKHAHKITADPDETVFLKREKGIERQYRMKCKKCSIPIYYKSEQDSNIVFIMDGALVQTAGEGGVTDIYKQVALTQPKKIMVTKHTKNMGKFSSVTVSTIDEEEDEIEAREVADSYANNARIIEKQLERKGMNKRQAETPAQTSEKRVRGTLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE90</accession>
    <name>A0A835GE90_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE90"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09418">
        <property type="entry name" value="LIM2_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09420">
        <property type="entry name" value="LIM3_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000022">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033726">
        <property type="entry name" value="LIM2_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033727">
        <property type="entry name" value="LIM3_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9412794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="403" mass="44523" checksum="EF38C397A87264FB" modified="2021-09-29" version="1">MVVLLSAECEESMSAGDMCVSAARAGPSARWHPACFVCSSCQELLVDLVYFWKDGRLYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMKHFACAECARQLGGQRYIMREARPYCLPCFDNCFAEYCDACGEPIGVDQGQMSHEGQHWHATERCFACHTCRASLLGRPFLPRKGAIYCSIACSKGEPPTPSDSSGIGPRPPRVPKPRRMPSPKSPPRTPPREPSPHHIDADSEPSESLVPEALADLRLEQSVTEHQIQPSPTSDDHKNESPDDWKPPHPVEAQAVVTPGHSSSMPELTLVDGKSPRKPRGGRTVRFCGDDNEAFEPDEPPRREKVRDEDASSYCSTCSSSSSSAESYTLPTRRAYGGVRISYVPNDAVACAKRERQRKNAQHDKNCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEQ9</accession>
    <name>A0A835GEQ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000168">
        <property type="protein sequence ID" value="KAF9413170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="6">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="186" mass="20690" checksum="EDC00286B4E2DCCE" modified="2021-09-29" version="1" fragment="single">DTFPNFTANTTAGEIDFHEYLGGSWGILFSHPSDFTPVCTTELARVLTLMPEFKKRNTKVIGLSCDSIQSHEDWCKDIQAYADSAGLPLTARAVFIIDPLKKFRLSFLYPATTGRNFDEILRVLDSLQLTDTAKVATPVDWKMGEDCMVLPTVPEDQISKVFPQGVTVVPVPSGKCYLRKTKCPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GER4</accession>
    <name>A0A835GER4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GER4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="35471" checksum="809B19DCFA77B228" modified="2021-09-29" version="1">MDCCNYGEYRGPGQYAPAWDGYGGYAPLPYAPYAHAYYAPHAHDPYARYYRYDYPSHHMHHEHVMPMDYGGYASKEARVRRSLARREQRAHTPAQHLPLPPTPPLECGMNGRGPAYCEPQMWPHYQQMGAMGGGGWSGANAANGWAPRNACSRDHMRYPPECRPMKSTHLHSQSQACQQDGRSTPYPVYEDSHYNGEGGARQRNTPEFTPAVTQSEASRAPRERFPVEPRRSPPEEKRPPPVVPLPAFQQAFGSTEIGKFAEAFSRTEIAVDDTPADNFMYESFPEWDGSVEPQWSSQPAAQPTTREIKCEDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEV0</accession>
    <name>A0A835GEV0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000166">
        <property type="protein sequence ID" value="KAF9413252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="88" mass="9752" checksum="F787A5BBF1C76ADE" modified="2021-09-29" version="1">MWSSQLLDSDRYELVPVINPNDGTRVATRGLCPVQQEQGMECCRPTSQDVTCHSKGGECVSNHYKCPRLLEVKEANDCGLDNTCCAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF13</accession>
    <name>A0A835GF13_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000160">
        <property type="protein sequence ID" value="KAF9413410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2204"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2282"/>
            <end position="2293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2293" mass="248254" checksum="77B0BE6798B9EA3E" modified="2021-09-29" version="1">MATRSRSEVVPTPEQPQTPKNERFDLRRTRTRSQSTVTESTNKDASLTREPVTRSRSRGSSRRPTTAPAPTSPPLDLTSPNIDESKIEVINSNLDDITKIPKEDTATSQFRRRTPAVQTTEKATLKRSRGRGSTRANARSLDLDVSGTTNTLNVAEKAPTTARTAPQPDLRNSRKLRYKTRPSETDTNLTGEGLVTTNEVIKSSQNKESVTSQAEIQNAAPTAVETIVQHITEANKPKSTTLKVTKVVRRPLGRGKMNFRPSVSLPKVSVSDEIAEDDNYPESFKALIQAKNASTQASSPTEESLSLKASQKVYKTYPASSQSTLTGPGTNKYSRFRNKQTAAEEQKNDDKEDTKGAETTVAPEVSKPRNSEYKPRGTYSARARKSTSSPSSTTASTISGQSTEKPTYKYNRKFKAPSTETPKAEVNSKPVELSNNLKKTFVRPPVYSRKLKGKTSTEASSTETVKIENPSFTKKMVLPRTSYYSRLRNNVKNELSSTTEAVVEITPESVPTTTSETVDVPLVIALLNNSEDRKTARIDAQPENNDNHMFLISVTSKESTENNTNNDIINTAEESENMPILNVSPTASSRLDSDKYRYHANYKDQNSTNDLDKEKGSSTVIPPVRNLQTRKYGRSRVKSKDGKSDVAVTSPKPRERSIRKFSESFSKTTEASTNGITPEPDKSKSRFSSKYRASYIDKPFYKPTVPTITSSTVNLRLSESLVKPSHVMNVEASHHSPSVTVSIFDALAEILTSTPKPRISSTTEVMKIQKLNTDVKQVLDGVSSNVNVNSVQDLAGQDTFMSTNADVSTTIKSVQPTVQGTPNVINSILVGGTVTQSLNIEDGKPPKDKTTTTSTPTQGSTDSPKMVYNTVSDLLLSNNNLVSSELTSMLSNNIINIIENMDENSRSKLKSLDMAKVLKSGLATVLDNADSIPNTTPYSLEDIRDTANIVIDGIESNNDLQSVSTGGNVNITVDNRNVPISVTQNPATVNIPITPGAVESTRSISSSQGTTAASTSTTTASVVRSTFDVTPTTAAATSPVSSGTDSLNVDIISETSDSTNKIVPLPFLTNFQSDDFTAGESDNLFSAATTPILKSLSLVSSYVSPPPRDIDEIQDPSQVSRLQLWVLSKKARVLKMIEDIIRQHNDELATLPPLTDFVSPSGSINLSERLTNIMNTMIASTETVTTRDIEPTSPMTTPSFVTNPMPTNVFETTTTSNTPTLLTTTTETVSSSNAPSTSETVFVSSRSGRTQAIDGTTGSSSDTTTTETSETINDVTSTMSTPTTDQKVEILSRLQEAAITTTTIASSETMETTTLVADTETTTQQNVETTTFNIDTTTSTDASDSNTSQTTVSTLSVGTSAIPKKDYVIFGILPNNTVVRKNPNEDILEQLTEASPYIVYGVLPNNTVIRKFPNGTRVPRVMQKIDILPISPWSLRNPYSPIHNNPAIVRPQPNPIRESTNTVTSTDTSNNGTERLTNDTVNNQQSMITPSALNIKSSNGITTTIMPEKSTASHVLSLRTTTMLPSIDEILLNSISSAAIQEMVISEMSSSTREPRILTLDIDPETKQIRTEKPGEGDGSAVFKFIPIDEVTVPPQNSNVLKLASTKTPPSTNSVQTEIQTMWTSSVTEMSTQTPQIQTQETTMNEGTTTQRTTIMPEITRYREDVQLLQTLLQATGRDPKNLNVNSLLLGDLTTTLRPLTTTTAPTTTRPPTTTRAPTTTQTTDPVKLLQALFTNPINPTTLSIPNVSGNLRASTGQQATTTTRSIEEDIRQFEEDTKLLQALLQATGQNPASLNIPALDKDTKLLQALLQATGQNPSTLNIPVISGVTSNVRIASNPQTTSLGSNPTTPLNIRPVFATTNGPVFQTFAPRTLTTTLQPVTDVGISTTFTPFNRERLTTTIRSAPTTLTGRRAPFTGFTSTTEMPSSSTFSVEEDLAFLKNLKTVLKTNPNNEDPEAALANRIIALAVERSLNEIQTGTGETVRTGKNIARPTTVNGPSIEDEIRQFQEDTKLLQALLKATGQDPSKLNLPTLPNLNVSPNLPSGVSDDLKLLSNLLASPSPLNEPFDPLTPKPTINSNVKEIKNTALPFGAKIAVKDNLKNDQDDEKLLQTLIKLQGAQETTTQRSKLTITGQSSDEALKKLIQQTQPAGMVSEATRAPISLSTEYGKSNDALLAALLKEQGFGPTTASSLDEQLRLAQWRETAPGSGAPRPNRRPEPAPSARPAPSISSAPTSNRGNWFGSGPFVGNADDRPGNRGAAQTVQSVIRAGQRAATDVYMNGSVTPSYSDNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFQ1</accession>
    <name>A0A835GFQ1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFQ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="65" mass="7405" checksum="CF3BBDC1A1435D69" modified="2021-09-29" version="1">MDVSKCNTRNPIPEPNLELPTPQPYPKYPATTPGPINSRADPKVQTYIMQNDAGEFVDLYCPRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFQ5</accession>
    <name>A0A835GFQ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_007736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9414339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="449" mass="52930" checksum="6B3018A9E627564C" modified="2021-09-29" version="1">MRVKMYEKMCRLCLSTQNIMFPVDESFVINYNLLTNLNITLSDGKPQYSCITCMENVKCFIEEVDDFDDKLDDYDVTDSNFDDNLEINNSLDKKDKSSSNVLKKNCKLVSENVSNLYHMKTKKKYMKKRETQVEPNQWYCGICPKEFYSISEMNQHVDSHKNERQCDICKVKVNSLSQLYAHRLNHVPVSQYKCHICNKTFKSNIYLEFHYRNIHIEEDDKRLSCDKCNILFSSPKRLCYHFFQKKQALRSHIRSHGLTKSFTCDMCDFSCKQGSGILDHKKRKHNPQKVNCNNCKKIFVNQNEYDKHTCKHNIKSLCPICGVQIKRNYSLNRHMLSHSDECKYKCHRCPAKYKTHSALVAHLNKHDGNRTKQCEYCPAKFYSSTVLLKHRRIHTGEKPYVCEECNKAFTGKHNLKVHMKVHGKNIIVKRKTENDDVIRYNEVFNNVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGA4</accession>
    <name>A0A835GGA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_007334</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="201"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="438"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="589"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="862"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="1015"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="1217"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9414865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1540" mass="180121" checksum="2A4762781F835FF7" modified="2021-09-29" version="1">MIMRISVPSATEITTRDFLMNSSKWSTMSSIYFKEVRDFYELTQTNVSLKYILVWTSLKTDPLFNLRVARDAFIERACPITNCFVTGNRELLHDITKFDVIVFHAPEFVQKGVQSLPAQRKPHQKYIFTSMESAAYYPICNQKFLNFFNWTWTYKLNSDLNYAYFSVWNKNGSVIGPKQEMHWMKVEDMAPVNDTLKEILNGKTIAAAWFVSNCGAPSGRDKIAKQLQIELQTHGLRLDIYGSCGTMKCPKSSMDECMLKLRSDYYFYLSFENSFSDDYVTEKLLNALDNYAVPVVFGGANYTSYRDVVASVETDPYCKLCEAINNEEEMSKTTIYEDIGMWWSPKTCQELAKKMADIIENKELYYEYFKWHNHYIYRDVVASVETDPYCKLCEAINNEEEMSKTTIYEDIGMWWSPKNYFKEVRDVHEETRTNVSLKYILVWTSLKTDPLFNLRVARDAFIERACPITNCFVTGNRELLHDITKFDVIVFHAPEFVQKGVQSLPAQRKPHQKYIFTSMESAAYYPICNQKFLNFFNWTWTYKLNSDLNYAYFSVWNKNGSVIGPKEEMHWMKVEDMAPVNDTLKEILNGKTIAAAWFVSNCKAPSGRDKIAKQLQIELQTHGLRLDIYGSCGTMKCPKSSMDECMLKLRSDYYFYLSFENSFSDDYVTEKLLNALDNYAVPVVFGGANYTRFMPDGIYLSANTLTIKELAKKMADIIKNKELYYEYFKWHNHYSYRDVVASVETDPYCKLCEAINNEEEMSKTTIYEDIGMWWSPKKCQVAHRTVPGHSLEKIIRNHESLVYKESPVVLILLLLYNAAKTAKDSHQITSKHQVISGSKETIVESQTFVNSEVRENVKSKDNMKYILQWTLPHNVPFVYMGKGQEGFVSRNCPYTNCFVTANRTYLGDYTKFDVIAFAGPEVVRYNKDRLPQNRSPHQKYAFASIESSDNYPVCSNLLNGFFNWTWTYKLDSEIRWGYMTIRDKNKTIVGPKKEMHWLKLEDMEPISEDFKRRLKTKTKAAAWFVSNCYSKSRRTAVAKQLDEELKKYNYSVDIYGSCGTLSCSRDNDESCNDLIKNDYYFYLSFENSFSEDYATEKLWRALNYDAVPIVYGGANYTRFMPDGIYLDARKLSIQELAAKMNELINDPDKYAEYFKWKNYYSYHRQHESVDTEPYCLFCTHLNNEEMVKKTTIYEDFKRWWTPPGRHENVPFSHIGLGQTGFIGRKCKYTNCYVSANESELGSVTAYNAVLFAGPELLDENIPLPEERLPYQKYVFASIESPGNYPLCFHNFNSYFNWTWTYKLESDVRWGYIVVKDVNGNIVGPKKDMHWIPWRDMDPVDEEFKYQLKSKRKAVAWFVSNCRTRSRREDYVAHLREELLENYDLDVDVYGECGANTCPRDKEKECDAMLSKDYYFYLSFENALTEDYVTEKLLHPLQNNAVPIVFGGANYSRFLPDRSYVNARGMGVSQLANLIYTLIQEPSTYAEFFRWKKYYSFHKTTDFKETNEYCKMCEALNNNELVEKHSTVYLFSEFWEVYDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH71</accession>
    <name>A0A835GH71_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH71"/>
    <dbReference type="OrthoDB" id="7399486at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032306087" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="94" mass="10145" checksum="186CE7CF4EBD6548" modified="2021-09-29" version="1">MNKLFIVLLAVCLVSVHAFVKRDAPAAQSETSNIQKQFEDIAATAKNIGDNISKTVSEALDSEKLKQQFNELMNAASKALDDLKAKTEPAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHV1</accession>
    <name>A0A835GHV1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHV1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="28198" checksum="E19DE6B0D977BA66" modified="2021-09-29" version="1" fragment="single">GPFPQPQSPIPPYVVPAQFRPFNANPYYQMPYNAPVFYPPNLPYNPYFAQPQQQYQQPFFQQQQPFFGNSRIAIFSAAWHERTRTSQSKRNLMQELGYIDSNMEPNYEQITQRISNLPVSSELKNDIQEGLQFCQKFSQCVPEDKRDIVPRPQEQIRAIFFFRCYKHKKLEACIMKDINEHFNKEYMFDSDTDFALSRSARSIRDVPLRDPSIEALEEMEVYLYDYLSGGGGFDFDLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK42</accession>
    <name>A0A835GK42_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK42"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF22">
        <property type="entry name" value="RAP-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="359"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="778"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1021" mass="110676" checksum="0CBAF06490BF1C54" modified="2021-09-29" version="1">MYAPDNRRKDARDVIYRSNSSLDLIYAEHPSGNGLRREYGSHGSIDVIGGANDRLPAMVHSYSGVSAPEKTPGLNRTVDRIADGLTTDHADGPPSRSSASPKPRLKLNKLWGGAAPVLNRAPLDDSGLSAVSDVNKRKQFAHYDCQSLMANLTYAAEIRGALLSRRRNTTTGASAASLLATRGLPPGEDAVPDTGDGRSNELLESCPFFRNELGGEEERCVSLCWKTARGAILGQSGGWHRPRAAYGISMLEFPPGQTHWRHGCPFARSLSPFPIESQDLGALYYRNYFYNQPHQNWFGMDENLGPVAISIKKERVELRRGGGDVSAPASQLAWQYRLILRTSELLTLRGSVLEDALPTTKPSNNSATYNTKDVLEYVAPELQVNCLRLGINNGGAEEQLLRLDEQCVTRHYKVGVMYCKSGQSTEEEITDSTGLYSVFTTYQGCDIMFHVSTMLPYTPNNRQQLLRKRHIGNDIVTIVFQEPGAAPFTPRNIRSQFQHVFVVVRAIDPCTENTHYSIAVSRAKEVPLFGPPIKDGAIYPKGEAFTDLLLSKVINGENAAIQSPKFSTMATRTRQEYLKDLAKNYVTASTVETGQKFSIFSSLLMKSGSNSTNNTLITRVENCTNDVLVGGALCFHVNEGAGGSLLDCIMGVSADTVVFVEDSTRQIVLVLPTSSLLGWVVSGGWTRVYYHRGESVRLRGGFHVQPDGLVTLVESSGCAARAGIKRGARLLEVCRAAVVALHHDQLVDLLKTSDPVTVTVTFASSTKCQCETGLEECGLAPGRGDAQQPGRPRRAYERGHSPPRSDSSGYGTGGSCRSGRRSPQTSPLPEAVRRRSHDDAASPRHNRHKRASANTSSLTEDLIRMMDAELGEGGRGSAVSGTGGSGPGGAAPLPLPDAGALDWAALVHTATRAMLQICEEHQYPSMDNTDPSLETLPNEPTTDSWNDVSATTEPVPAAVSGSGVSATDTCACGLAGRVAALENDAAAAQRHRHQLEEEVLYKTKSFFITLCTLHIFPKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKH0</accession>
    <name>A0A835GKH0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKH0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13860" checksum="6EFB9EAEA56890F0" modified="2021-09-29" version="1" fragment="single">MKIITNLLKDTKDEWLVRTTATINSANPIVDRIMEDDSVEGVIMTNKEGAPILTNVSITAATNYGRALHKFGVLSQMYIKEVNPLEEIMILRIHTKKNEIMMAPDNEFNIIVIQHARTRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKY9</accession>
    <name>A0A835GKY9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="793" mass="89598" checksum="DF56665463F5A860" modified="2021-09-29" version="1">MECYVVISFIGEGSFGRVFKAKHKETDAVVALKVIRKKGRSVKDLKNLRQECDIQRQLKHPNIIRMIDSFDTDSELVVVTEYAEKELHSILAKEGCLNEDKVKKITWDLVSALYYLHSHRVLHRDLKPQNVLLDSSGRAKLCDFGLARIMTNATHILTSIKGTPLYMAPELIEEKPYDHQADLWSLGCIVYELIAGQPPFCTMSIWQLVRMIRHKPVQWPSFISSDARSFLQGLLHKDPMKRMTWPEILEHPFVFGHITILPEDAMECVPMSDDDSVRATSAFSVRDSLKTDDEDQSHPITADNAKLLRHEYNVLNNSNLVVCNLENNMAQLMAANKKQSDLNKMDKIDEEKINTEKHPEDKKPISASDSKRELLDAKQKVKSIDTASQSLEHPKSSTKCSSEVSSGLSKSVPPSYKQKILQFSRDKLRFGSGGNKLTRSIKRSFHFSRSWDKNKTDTQRRTSEPTIEVSSLIDDKEKCSKEEKDHDIEKSEIIEEISDEKEIADNDRILKTDDKSDVKEPSSIELEEWEAFLNSNISEVMDGDVESLTQLNMVSMVIGVVGSAARASGGGRVCGAVAALLALPALAHTLPRHTLLNIQDVYLEAKVVYNFVAAINTLMKDSKYNDDGAQDRLQGVGRMLEVCAWLCVRSCRGVRQFATALTAYNAYPVFTRLLMHYSKSPRIVLNIVGLLITVLQDLPEHADVVEKILFDEEKFNFIRLVEQPSDALRMRVCILISLLCTFSCTAFSVAMETKWSKKETESIEALHTHCNVALNRAARLATKELSNMPFYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL52</accession>
    <name>A0A835GL52_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_013145</name>
        <name evidence="7" type="ORF">HW555_003475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000654">
        <property type="protein sequence ID" value="KAH9633468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL52"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9633468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="130" mass="14566" checksum="9F608693C17C1DF1" modified="2021-09-29" version="1">MATVKFTRKEIEARNHREEAAIIIDNVVYDVTEFMEDHPGGVDVLLDNAGKDASQCFADVGHSDIALEWREKFVIGEVVDEDRWPEVKRVVHEAPPAEPFTLMTLLNIWGPPIVLGGLAALVYTYLFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN65</accession>
    <name>A0A835GN65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004485</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="13">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="16">
        <location>
            <begin position="289"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="15">
        <location>
            <begin position="445"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="602" mass="66317" checksum="06D0EB97127E810B" modified="2021-09-29" version="1">MGHQLSEGSLELIMNGGVYDKPIMQVLGSKKIQGSGANERFRLLVSDGKHSHSFAMLATQLNDKLISGELSDYSVVQIDRFVTSLLKNTGKGEKRVMIILDITIVAPGNEVGKKIGNPQTWTEESAGAAPAQAAPSPAQRPAPSPAAKPMITPTPNLDSSLLSSQMTHPIASLSPYQNKWVIKARVMSKSDIRTWNNARGEGKLFSMDLCDDSGEIRATAFKNECDKFYDMIQVDKVYYISRCQLKTANKQYTSIKNDYEMTFTANTVVAECMEDSSSVPSIKFEFVPINDIATKNVDTLLDVIGVCKAAADLQELTARSTGKLLKKRELTLVDNSGGAVVLTLWGKEAESFEGNSNPVIAVKGARLSEFNGSKSLSCLASSMIRQNPDLPEAHKLRGWYDNGGADMEIVNISARAGGYTGGSSEWITFSDAEARQLGSGDKGDYFSLLGVLTFTFADNAVYKACPQEQCNKKLVDQENGLYRCEKCNREYPNYKYRLLLAANVSDATGDQRITAFNEAAEAMLGRNVAEIGRLFEYDKTGYTQMFEEVKFKTFVFKFRTKMETYNDEARLKTTVMNVQPVDYKDANKRLIASIKTLSGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNB6</accession>
    <name>A0A835GNB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNB6"/>
    <dbReference type="OrthoDB" id="6080988at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13085" checksum="08B93F5654D29B40" modified="2021-09-29" version="1">MPILKIFTNLPKSKIPADFVNKILPVLSRTVKKPEHLFICMVSSDCSLSFGGNSTSPSALATLESIGNLGVEENRVIAKEVTDFIEKELGIARDHFLMSFYDKRGRDIAKGGVTRFPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNN5</accession>
    <name>A0A835GNN5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNN5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="123"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="328" mass="35979" checksum="77C28A9A49AA80DF" modified="2021-09-29" version="1">MYGHHLQPCYFGIKNCPSFALNHALLFPGVPLPPSDHQPFIIGGEDAPEGSAPYTVALIFGERVMFQLCGASLISRRLMLTAAHCIESFIADDGGLLNPSFALNCAFLFPGVPLPPSDHQPFIIGGEDAPEGSAPYTVALIFGERVMFQLCGASLISRRLMLTAAHCIESFIADDGGLLKTLHSRVGSNQWNSGGTMVYLKGYHMHPQWDSINIKYDTAVLHLQPTPDDKQVLYMNTLDYDQCQEQMKLASNNNAPPIQRDIELCTFHSRGHGMCFGDSGSALVRLSTMQQIGIVSWGYNCAVGAPDVHVRIYGIKDFLESTMALYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNV6</accession>
    <name>A0A835GNV6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNV6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="60" mass="6830" checksum="81DF21CDA86F66F0" modified="2021-09-29" version="1" fragment="single">MDENSSDRTSDPLLRQTSSSNTNNCNNQSENRFVIAQCRRNEDQTTTGQQESSEESETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP07</accession>
    <name>A0A835GP07_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP07"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="101" mass="12019" checksum="D82D1660DCB01078" modified="2021-09-29" version="1">MDILSAMAKKFVSYNKYLFFNMNKVLLCLILAFTFTIVYFLRSLLVKEAPLLLLFVLFILFLVNVIRTPQSYKMWNVKPIGERERYEDKLRRANTRPSCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ77</accession>
    <name>A0A835GQ77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_002641</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000035">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF105">
        <property type="entry name" value="CYTOCHROME P450 4P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="1443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9421426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="177381" checksum="EC0CC38649AD0D1E" modified="2021-09-29" version="1">MVQECGERRSVPPEGVHVAREFPCQHTYTTQARRRACYITKKAVQAFPLDLEVDADCKLLKGTSSSSEKSDSDSGMIICLLGVNNQYCFQYYCLTTLCKMIAYLVITVIILCTVHILLNYNRKARLIRKIPGPRDDFIIGNGFTVIRSPVETMQLRRQLCTEFDGIFRVWICPMGAIFIYNPEDIEILMSGMKFGEKSFVYNFLKNWLRDGLLVSNGAKWQTRRKILTPAFHFNILKQFCEIIDENSEKFLEVLQQNAGRPIDVVPVLSEFTLNSICETAMGTQLDDNSSAARSYKKAIYDIGCLIFDRFVRVYLYPDFIFNLSPMGRRESKYLKVVHSFTENVIEQRREYIEKNGININEEIEADDDDSYVYKKKKKTAMLDLLLSAQKEGHIDKIGVQEEVDTFMFEGHDTTASGLTYCFMLLANHKKIQDKIIEELDEIFGDTDRSIKMEDLAKMKYLECCIKESLRLYPPVHFISRNINEETVLSNYTIPAGTLCHILISDLHLRPDLFKNPTVFDPDRFLPENSVGRHPYSYIPFSAGPRNCIGQKFAMIEMKIAVARVLRKFHLSPVTRPSDITFTADLSYLQHQCIRTLHKMFLYLVGIVIFLCVIHIWFNYNEKARMIRKIPGPREDFIVCNGWTVIRSPVETMKIGREYTSQFDGIFRVWIYPYGAIFIYNPEDIEIIMSGMKYGEKSFVYNFLKPWLRDGLLVSNGDKWQTRRKILTPAFHFNILKQFCEILDENSERFLEVLQQNAGKPIDVVPVLSEFTLNSICETAMGTQLSDDNSAARSYKKAIYDIGSVFFDRFVRIYLYPDFLFNLSPLGRKQNKHLKVVHSFTENVIEQRREYIEKNGININEEIEADDDDSYVYKKKKKTAMLDLLLSAQKEGHIDKIGVQEEVDTFMFEGHDTTASGLTFCFMLLANHKKIQDKIIEELDEIFGDTDRPIKMDDLAKMKYLECCIKESLRLYPPVHFISRNLNEDTVLSNYKIPAGSFCHILILDLHYRSDLFKNPKVFDPDRFLPENSIGRHPYAYIPFSAGPRNCIVELMKLGRTFAKKWNGIYRIWVYPFSAVVIYNPEDIEVVMSSMKYGEKSLVYKILQPWLQDGLLLSNGTKCQERRKILTPAFHFNILRQFCVIIEENTHRLIDQLKKTDGQPIDVVPILSEFTLNSICETAMGTQLNEHSTAKTYKKAIYDLGNIFYHRFIKIYLYPEFIFNATSLARKQNKAVKTVQSFTEKVIRKRREYVKEHGFDMFNQNVDDDEVYVYKKKKKTAMLDLLLSAEQEGLIDKTGVQEEVDTFMFEGHDTTASGLTFLFMLLANHPEIQDKVVNELNDIFGDSKRWACMDDLPKMKYLDRCIKESLRMYPPVHFISRKLNDETILSNHSIPAGTLCHIPIYDLHHREDLFPNPEVFDPDRFLPENSEGRHAYAYIPFSAGPRNCIGQKFAMLEMKIAAAAVLREFELKPVTKQSDIVFLADLVLRNNGPLQVSSERVINYLTYNVVQHDIKRNTTINHYFIKRLPKMDTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQA9</accession>
    <name>A0A835GQA9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_000869</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQA9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="169"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="360"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="524"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9423811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="620" mass="70496" checksum="82AB7F215A3A7ACB" modified="2021-09-29" version="1">MLIMDAYDIFKKLTKGLTFKNKVLGVKNNGQVSKPAIKKEEIEIKEEKISDTEEELNNGVENSGTESEDQNSDEEEQDDLQLVEGVKVRQEKKKKQKKEKTEDLKKKLELEEQNRFRNEHGIKTVGRHVPAALQDFSELVSRYNVSQALVDTVKQCGYSEPTPVQRQAMPCMLEDRQILACAPTGSGKTAAFLVPILHALGAPQGGPRALILCPTRELAQQIYREALRLSASSQLRCSVVRSIKESKVKEREATIRKSDIIVSTPNRLCYLLNQDNVNISLEKIRWLIIDEADKLFEGSEDQSSDFRQQMEQILAACGSKQRRVAMFSATHTPRLAQWSRRHLRGLINITVGHRNAATNLVDQELLFCGNESGKLVAFRQLVQQGLKPPVLVFVQSKDRAKQLFKELIYDGINVDVIHADRTQLQRDNVVRSFRVGRIWVLICTELMGRGIDFRGVNLVINYDFPPSAIAYIHRIGRAGRAGQKGRAITFFTQDDVANLRSIASVMQQSGCAVPEYMLQLRQDPNKRKKLLTKAPRRDNISTRLEKRPDKRKLEAADEVMKADKTKPTDSIKNAKNNKNRRTQNLEQNKQKHDNKADSKNNKKRKKKNLGNKKNKKVVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQM0</accession>
    <name>A0A835GQM0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQM0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="230"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
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            <end position="411"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124937" checksum="BB6FE6AA5F52E173" modified="2021-09-29" version="1">MQTIESGNVKKNPQPPKPKQINPQKENATKPIRKQSAIRVMPVFAKQALTNVLEFIASDETTTVFSPNDCVEFWFYTRCIKWVKEDKRVQWTDETRQLFGQLKTMLLTHNVVARRKKIDRKNETTLKYHQITYTKSPLSFTPEKKRLRKKKRDKKKLQKMIDRQKQTEKAIERRNKSASEESTTESSSRTSSVDRRKREKPKKLNQKMDWRDIELERKGKLREGLSMPVQSDKAMRMMRGMGWSGGALGARGNGIMEPITLEIDQPKGVGFGHWKRDKVKPQVVQNKKPFPKSIQDWINDIDQTDTPPLDTDIIVEKTKKLLQENISFDIIMNEGFKVPKVPENVPVSSKKNEQPSSTIQKNEPHSSKTLKNEPQSPQNIKRSNNESSAPQKNELQNSTTQQNELQSSKNELQNSRSKILIIYNSQLDTMRDDSTASLPIISRTVLRSPRDIRNDFLQAMLDIFTKNLQVKTLKYFKGISGKEKRFFKQALEQLNLDNAKHFPPLEKNIVKKILNEYRERPNIVVKAILSDSTKELSLRPIPVKLLPVKRLTNEENINTYIHTSLPIFATQSQFYGLKLAISILLSLKDFLNSKSDELDIDFTKVLNRKQISYVEHTVENINARVKNGSSPAEANISTEILKSLQDDQLFVSVMFDHSYRSLTFTKHYHNLAPNSSKPKEISHTVIYMDSTSDSSSSPYKKPSRPIITEADITDDDASSLSEDVHLPKLPPLPAGKEGVNLKEYAKLYNRMDEKENTSIAEKIIRIMENKETDSDNEKVLELGDRKTMVRTDYAKDVCDTSVEYIVCVNHQETCDDGIPQKNMDDDANNEKDANDLPIYEKLPIFEGQGSNSMKRSNELDSSLTKQKNTSLRLVENESKLDVTEPNNAISKDCDFSKINLDLSEDICDNNLESVKKTDKIKSGVIIVYIVHANDPIDKINKDKAREIQKVMSDNIVGGKKLPLLKCHGYLYDALIYSCQNQDSYVWLESVIQSIGDLKILIKNHTKMVLSLRCLYDFDTHFLFNMLELYNEGLSTKYWEVVCKKEHEDLLVRMFVVEMDEASINYIFSSNMALYAGVDKVEFTLACGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQV0</accession>
    <name>A0A835GQV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="2355"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="2411"/>
            <end position="2459"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1556"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1599"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1808"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1829"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1905"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1942"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2017"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2324"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="2541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2541" mass="279153" checksum="016D56697B2A35AA" modified="2021-09-29" version="1" fragment="single">DDAGTATNASRRASAREKDVGLAEDVNATSSFQQEPSETRTACDTPAMSEDNFDGDSVPSPSAQDVNASTEAILDMIDEIVDGPGAPKRVPLESESVDTLFDELEITSEHSNIIIQESSKTLSDNITSQPAEASPAENAKSDSPLQFGISSQTESSLSDLSPGVLNTDSVDSLPQSSSLPEAGEPAVSTQPEDSALSKVPEVPEASEAPAICPPPNIPSSSEEKTVQNITDSSGECETQERTVKCVSSSDKRDNVTVESAESTSSDSSVSEGKAVFVETPVRSPLKRRLVRPAPSDRRPDSTVSSTVDSQIVHLPTTEQTSSENITKDVTSSSDAVPTLHGNVKPEEIRNVSEINFCKAETSSSPKKIKLIRQKVISGTNNTDNSINQTAIQSDKDQCQSTSSESHSLPLPEPHSESSNNINISQSQDSNEPLIPVANCISEKPVNSPVQTASSDEHSLTRIEHSHSLKLEQVEKHDSNEQIPSGQSTLCLPNALESIKHIVDENNVVKETSSISLPNSASPQAKIIENDLNPDESNVNYDEHKDTKDIESAQNEVLPSLQNTPACTQNFEGSKLECTNSTAENHTITQDCEKSQGHTEGHHHRNDQNEIQMDDHTQVEDQKKQEHEMQVEEHLERQDHTQALDHTQGKDDRQLEEHTEKQDHTQVQNQTTQENNMETPPPDHTSDPVSIQMQDKIQMSEPKHVQEDEKKVPPIKLNLSMANLSESNKETDHSSISKTNAIHEESEITKQVPKLTIKLKQSDEIKSPVPKVTIKPIKPPVEQDSDDNTEDNHQVPCVTKINIKPIPKPTENIIEGSTRSNASVTKLNIKPILKPPEKINDFHRKSSSSEISESEYSENDETSTSDQASASDQGPSDIVPKVTIKLGKPGTESEGKFYTEKNIPKLTIKVQQDENDDQEPKLKKMVISQSEASSDTQLEKVPKLTIKTISKSESQPLSPKLTIKPLKPPDVTNKDGEIPKMKISTEPTEVKESPHVPKITIKPVTRSTAMCDSPEHIPVVTKLNIKPILKPTDSGEAPESFEDKVPVVSKLNIKPVLKPKDNDVDSSVDDVPKITKLNIKPIKNPEDNSSEEKDCDELNADIEKNSIPVVTKINIKPIIKPHDEETLKDSENQSSETGNSSDDNGDHIPVVTKLNIKPIVKPDSSDESSKTVSSSEPSIPVVTKLNIKPLIKPGESISPSSPKKEHKIDGHSPTIPIVTKLNIKPVLKPEDPDVTKSKEDSLDKTPSKNPPLVMKINMKTMTENFNNEHASCNNINEPLPMSPKKGKVTNALESKSEGTLEKKRSSEPVNDVQAAIKDNCVPDSIEKNADIETPFVNKQPSLISDKEKHSSEAGPECDSLVTGSSFPESSTDKMPVINATGQEHKNINFGPTDSISEANMMQTITRSKYSSVQNCTLLKKLLENKCSLDKSLDVSPIVNYSLPAENKTLNSDHLVESGKSSLDRLSSGNIEKIERRSATPDKINDSKRSVDSNTHAIQDHCDKANENLTKPLEITISDKVTNQSSGQDSPRIILKINKTDHGPSAKIITEEVKRPDVQQNLSENTQDLANDKSSKRLRSSRIVENTEKTPIARRNMGKRPSTTDTSPPQNKDSELSLLQSKRLKLGQLLGNKSLTMTPVTKTSPPSPTKTGLDLKQGVKTVNHSLLNNENCSKNGNSKLHNILSNLHAKQMQSLPYNNTNCLEKPQTVATDKEINASVSSLDAVETAPVENSHPELQEMIINENSEFGTTPEEVSQDPLEVARPPEESPEIVEIPKSAELTPQPKKRGRPRKLPVSEGAKPVTLPVPALEERPQRSLRLMRDRPAILTKPRGRGRGRGGRRVEATTPPTELETIVVIEPADEPEDRPPPADIDPTSSRIKLPRMTEALDKMPSACVTPLTSRRRNSSGNFSTGESSELKVVLENAKMEDMSKTPEVSGSGRGRGGRGSRGGRGRTPRGRGRGRGGGRGATYMKETMGIYGRVCGPATTTVQLFEEETCMMDDNATPAKPTHLLDEDSQSSVKSSTNESSKMKKSKFADLFDSNKVWTAADVKEYTWPPPEKADVEHKAKNALDAGSSIPYYPQDPDSPTVMMIQEQVAMFLGVKSFKRRYAELKRRTISGEERDYVLSITAVDASEVLDIMLSDYPHKYEEYRSYQRQRQLAEAAEEPAEEVKTEEKVVKVEMKAEKPVEHKPELPKIDPEKTRQDMAAAAIASASEWNARTNAMRRGACADLQSLTVQRARAAPPAPPRAHLRPPAGFYPHALLPGQYQHSYRVYTPDQLRYFPLNTVLAAPPAPPSEEWSSESEPDWGSRFSSSEDSDGPTHHSAKRKKLTKTKRSSQAEVRESREPREETREEDLCRVCKLRLEANRRYTHERFLVCANCNAKLHPSCLELSADTIRKCREYAWQCAECKTCCTCRQPADDDKMLFCDLCDRGFHIYCVGLDTVPSGRWHCVECAICKSCGARSPGGAGGAAGAASTSEPAEWHHQTRRGLGGHKVYSHSLCTPCARSVPCIPTHSSLRLVLLSYRSSALTLSPSARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQY9</accession>
    <name>A0A835GQY9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21443">
        <property type="entry name" value="SNARE_NTD_STX6_STX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF224">
        <property type="entry name" value="HL02043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="233" mass="26727" checksum="85008AA96C7F0101" modified="2021-09-29" version="1" fragment="single">EVFKALNKTRGLYLRWQEISKAPTIPNSPEVEWTSTELRNALRKKNSSKFKIDNKEISERRSFIEATKQEVKVMKSKMSLNRNRDNDGTAREPLLGDESPVHNMSNVWTATPKYTKYSKLANQTDSPNRFDYDSDIMSMQEKMLTSQNDQLQVISHSVGSLKTVSKQIGIELDEQAVMLDDLNTELENADSKLDSTLKKVAKVLHMNNDRRQWLAILILVGLLMIILILFVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR33</accession>
    <name>A0A835GR33_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_014807</name>
        <name evidence="6" type="ORF">HW555_002512</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000493">
        <property type="protein sequence ID" value="KAH9636546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR33"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9636546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19036" checksum="2183FA62E09AA6B0" modified="2021-09-29" version="1">MARPGKEDAAEDAKKIVDDAKNFIEKAVADIGKTSATKQLILGTTSGWITGFLSMKIGKIAAVGLGGSVILLHIASQKGYIDINWDKINKRVDKISDKIEKEATGKSPDWIEKVERFVDRKLDKAEDLLKKKEVKAKRWVHNITGDDHYRATESHVFLASFVAGMAIGLLCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR87</accession>
    <name>A0A835GR87_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR87"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="638"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="773"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="89201" checksum="E2E5875C8809F8FA" modified="2021-09-29" version="1">MTAVKKVMAMRQLDSMFGNMNLEGEGRHSPLVSSTVEHDPRCEVHGRCSTPYRSSLYLHSRESTPGYYRDSVSPTNGLIIRRRDSLGLAGSPARELEHPSTFPSILRRERHSPSVTPPRRETPSPTHRFHNKRHSMGSFPNLSRTNVINYNRRDSISSNSIRDMKRDYVGSTNSLSRKSSIDTKKSSTDSLDVWHGAAWDSDKTNSISSLVHDERISFGPNKIGKIAEEQPDNDSGMFTSLQRSFLDYIRTEPTPPRSDDLSRSDMKSKPAHFVDAPFRPWPPLSRQAPQPNFYFRPPDPMDLRNFKTSSSKGSTYSDFSGMSAYSNKSRDYYFLSPSYRSAGAPTPSGHGDLYGARDRPRQLRNPNPSPPAACPCSRSRSLEDVRTEVVTEWEDDDENGNRIVAPATKFNRTSYKANPTFQKQGFLTRHSMENLVDRPPQLLPPKRISAFQAQLRNGGHTGVPISNPSNVGVGPEVNGSRPTFKPVTVLEDLQAVRCAEFHPNGKLYAVGSNTKTLRICTYPKIEDVKDTSAPTAPTVLLKRTKHHKGSIYCLAWSPAGDLLATGSNDKTVKLMRFNSHACNLEGQEVELTMHDGTVRDVCFIEDTSNKTSLLVSGGAGDCKIYVTDCATGKTFQALSGHSGHILSLYNWGGAMFVSGSQDKTVRFWDLRTGGCVNVISPPAGQPNKGSAVASLAVDPSGRLLVCGHDDGSCALHDVRGSRALQRFTPHSGDLRSVRFSPGAYYLLTAGYDGRVVLTDLQGDLTCALPSVPVARHPDKVISARWHPDDFSFLSTSADKTAVLWTIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRL3</accession>
    <name>A0A835GRL3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000947</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9423889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="465" mass="55730" checksum="8FFFD53AB118853E" modified="2021-09-29" version="1" fragment="single">KGKVNKLAKMSDEERARYLQHRADMEEEARRRKQELIHRFIKNMLTSFNFLVERKDRLIKTLVKATDDSDEQHRRAFQAHTENVSYFLNIGTQRLDKLQAEYDHQKNNLLENWDKEEMELIDCQDRAEFKLKLIMYIQDRDFQMLRKDIETQRATEKNDARLEHEEELRSFCAPKQLAIEMYWGKLREVYNSYQEEHNPIMSHYHSLREKDDFYQKEIARNDYQIQLACETLTNLQHEWQKTTSTMTDKLTRMANRKEELTRKYLQMKKDSKLESCKGSQQLDIMVNASQDAIKHLEDMYEKLNKVMQLSEICSKYEHEGDELSKDVEYDLASVDFEHLDKDMIDECKEYRKMDKFLLKVNRAKVQTICLRTEKAKLMRENIQLKNYIKRYLTDLALKGKDRPLSMKIRTDAPKINIKANRPVTCIEGALSNAVQHEVRMRNVARRNKDNNIRAYPRVQCWMQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRV7</accession>
    <name>A0A835GRV7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="2 5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5 6">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5 6"/>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13614" checksum="15CB81015E79BD95" modified="2021-09-29" version="1">MLRVLVLTAVTATFRSNFATVAAMNFRSVDFEVFGRVQGVFFRKYTKEQAEKLGLRGWCKNTSAGTVLGQMQGPTDKVEAMMHWLKTTGSPSSKIEKCEFRNQVDIENYTFNKFEIQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRX2</accession>
    <name>A0A835GRX2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_000841</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRX2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="50"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="259"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="544"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9424132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="599" mass="68835" checksum="B043D769F2B693D3" modified="2021-09-29" version="1">MSGLKRCISQVSMLMTGKPINSSESAWSEELQKYRQARYAARRVRKRVIFKHGDCNVVQWNVAKRRRRYLQDIFTTLVDAQWRWTLLVFALSFILSWLLFALIWWLIIFTHGDLTPPPPNENVTFIPCLNNVNSFTGCFLFSVETQHTIGYGSRTTNEECPEAIFVMCLQSIVGVFIQAFMVGIVFAKLSRPKKRAQTLLYSQKAVICLRDGQLCLMFRVGDMRKSHIVEAHIRAQIIRRKVGLIFAKLARAKKRCTTLLFSRNAVICLRDGEYCLLFRVGDIRKSHILEAHVRAQLIRKKITREGEVLPFYQQELKVGADGEEDRLMFIWPMTIVHKINEKSPLYNLSASDMLRERFEIVVMLEGVIESTGMTTQARSSFLPSEILWGHRFETMVTFRKDTGEYEVDYTRFNNTYEVDTPLCSSKQLDELRATVSTSQKLDRMLGTIPKTFSADTLDLSSVDSMSLDEHIEIKIPEARARENRLMAQNNFVHHINEKSRNPSHTHLAVENLQEIHRNPVPVEYKHPESKEHMHRSHSHASMKKVHGLTPNGIGHAGNGHSDHKHDEHNKMRKSPSENHIGNKQPVIPILVTSPAPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSJ1</accession>
    <name>A0A835GSJ1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_015033</name>
        <name evidence="2" type="ORF">HW555_001658</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000782">
        <property type="protein sequence ID" value="KAH9631048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSJ1"/>
    <dbReference type="OrthoDB" id="7478445at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9631048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="118" mass="12194" checksum="D3D73328EE4C9286" modified="2021-09-29" version="1">MADAAVEKNDVAPEEVTSTEAKDSPVKKSPAKKVAEAPESNGKEENGSEAPEDAPAENGDAEESNDATENGDATEKKEAGVKRKSISTDNGDVEKTTPEKKAKVAEEAPPAEAEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSV7</accession>
    <name>A0A835GSV7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032873021" evidence="2">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="290" mass="31197" checksum="DB10668BB127DB4A" modified="2021-09-29" version="1" fragment="single">MATTALYILLAATAVAAVQVAFVPPAATSYIYRSDNNGPASYIQLGAPAPIHHAPHNAFAPPLPIIQPKFGAIEALDLAPVPLISEEYSGHDHGHAFAKGGGSNYGEKHHSAHGEKGSKGYHTEDHHAKGEAGHYGKKHDEGYYKEAEGGEKGHHDEAAVHGKHYKGGKSYKGGDHGHKKHFSKGEDITGYHKVFHKDEFKKDHDFYDVADKSGHFNKHGHENEHHGSEEGGRKEGGHHDSASNKGEFGKSGFHAKGHINDAEAGHSAEDGHESHYHNEADFGKKGGSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT14</accession>
    <name>A0A835GT14_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT14"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="9">
        <location>
            <begin position="532"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="10">
        <location>
            <begin position="656"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="765" mass="86501" checksum="E5D4FBF7F212D23B" modified="2021-09-29" version="1">MAPSTDWDEIKRLAADFQKAQLSSTSLRLSERNCIEIVTKLIELKLIDVIFTTDGKEYLTPQQLIKEIKDELYVHGGRINIVDVAKELNVDLSQINNCVSEIVKGKEVQLVSGYLIAHYYLEKVAREVNEKLQLQGQISVGELSLHYDLPAELLQHNVLEKYLGKIIFGKQDLSEPRTFYTEEYITRTKAKIRGALMGLLKPTPVAVIVNHCNLTDRLFSSLYDQLNAPGVLTGRQAGALYVPSCYTKSQNDWVMSFYKQNNYLEYDALSRLGISDPKGYVKRILTNEDLTFLSSCVIGSQIKQQLETALEECIASRSYLDVVTLLPSVLTDTDIENVLDDLLKKSKSTILFDNTVFSHHYIETLKQACMPLTQQKAESVVKSGVYQQFHMEKQINKAAEFAQTTHVDHKAERREERRRKAASGKGGGGTQGRETKTKAVKKHARGKQNTHDSDSDDGPSVAKKSQAQLEIITVDDVENVIKQTLENEGLEDLVTRVAEHLQGSLNQIGLTIAKETADKLLQDASQNRKQTHTSTQDKINILVNDIKLYEKGLKSLSADQQPQFIKYLLKSLGGDVLAELCKYAANQCNISVQGEVLTVEQRNKIMNDLPDEFMKPLVSLNGTLSEQNMESFFQAIDVCLSEFGMILKKVDKKKDKLLVQNHREKLISELETCEDPALSLHMAVLAIFTIVTQNMLHASGRQVPIIISYLKTQLKEDDYERLQLWHELVSKYLTSGEEEKSEVEEKLIQELPLLKNMVQEIKKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT29</accession>
    <name>A0A835GT29_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT29"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="66" mass="7419" checksum="4753ED5074B0D1B2" modified="2021-09-29" version="1">MRILHFHWFDGDCMPQSVFDAIVHENNKQNNIENDTTDNAGVSELDTDESEVDSDSSDEGASTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVH8</accession>
    <name>A0A835GVH8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Diacylglycerol kinase</fullName>
            <shortName evidence="8">DAG kinase</shortName>
            <ecNumber evidence="8">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVH8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="11">
        <location>
            <begin position="154"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="486" mass="54340" checksum="323AF424647F63DC" modified="2021-09-29" version="1">MDESKIETLFDLNNALISNHYFLVGGAFLIYLVYRIFHSLISENNYMRTRYRTRGHTWRSIQCNKSVPYNIYCTNCCKLMLPVVGLFCECCAVSACKKCHRSIDKKLRCKSVVWPSDKPFFHHWVHVGTSHSDSEDQHEEGLNKYFCTWCQRTKLCAHTNALENESGSNRSDEVLSLFRGLLNPIQVVDISSTSPENVVRWLPPRCRILVAGGDGTVAWVMNSLSSFPHVKAAVAILPMGTGNDLSRVLGWGAGGHTSLDAHNIIQSVRQANHQPLDRWKVTIMPKRSRLVRYRQPRVLYAYNYASIGVDAQVALDFHHARSQFLYRYASRTLNYMAYAFLGVGRALDDGGCGGLERRLCVWVGGARDPLTLPPLQALVALNIPSWGAGVDLWSMGSEEDVGEQSIHDGKLEVVGISSSFHIARLQCGLAEPYRFAQASSLKIELEGSCAMQVDGEPWMQGPATILIEPAGQSLMLRASAKQRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWJ1</accession>
    <name>A0A835GWJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-like protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39817" checksum="E3C962B21744D8BD" modified="2021-09-29" version="1">MAVIYKKSGCYLIDHREFITNVYKKTTVTESETISFSLLSQLFSILNIVHNQNRKRPRNSDNLHEETMKIKAAYEKFLHEIPSDIKNNLVDKYKLLDTSDVRDLSKKLFESTLFDFMGMKGGNNAETSLKCRIKENDFLIPPNSRFYCGCVKEQCLKLDGNKFDIVVADPPWWNKYIRRLKNANEKLSYSMMYNEDIAAIPVQNLISGNCLIAVWCTNAPSNVAAVKNIIFPKWGVEYVGTWYWMKVTVDLQPLCSFGSGCKKQPYERIILGKVGDINDIPDDQVVVSVPSALHSQKPPLLDILTPFVKTENPQTLELFARYLLPNTTSVGYETLKWQHESLYEEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYG3</accession>
    <name>A0A835KYG3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000382">
        <property type="protein sequence ID" value="KAF9408447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYG3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40558" checksum="5067CA94B014080D" modified="2021-09-29" version="1" fragment="single">CTLPVPTPVPAVASVGISNPVVTPDTIVFRRRMAGADDEPATRTSSSRTMLPLDLETNTSQIHYMDSLCKDHFLQRQYRKVDGGVLWSRNERNLDCTVTFQTHSILQRFMLHFDLLQLDCNDHLYVYDGAHATAPPKVGRPVVSQHQAASRRIVHRSNFVTLKYVTDNWGTDANGFRLVITAVKDPKHGCKEFRCKQREFCVSADLTCDGVDHCADGSDEDTATLCPVMAAAVARAQKRARRDCRETRSSLRARAGRRGRAACGGRPECRAAQGRVVRLAARGPQGGARPPPASSVTQCKFIDMTLNIFGLWLVCYWVVLPTRILILCLYTRCPVKHIPQIFITPCRKRITDSRVAGILSERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ47</accession>
    <name>A0A835KZ47_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000443">
        <property type="protein sequence ID" value="KAF9407706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ47"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="56" mass="6254" checksum="BB9F4C659ED63025" modified="2021-09-29" version="1" fragment="single">MAGQELDDNPKLKGFNRLFNSQTNRGRANTSKVTLGLIAASIVYFKFLKGNKSKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ80</accession>
    <name>A0A835KZ80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000523">
        <property type="protein sequence ID" value="KAF9406973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="30101" checksum="371F67D425653A31" modified="2021-09-29" version="1">MTTPKRERSINFSPEEVELLISLVVQNKTIVENKKSDAVTWNEKEQCWKTIEEIFNSTSGTHFRSAKTLKAKYEGIKRITRQKSALICAESYRTVGGPSTAVPLTPIEEKVKNMILLPVDGIESELEFVPEHVVEDHILTHNKPLQNDDSDKELSSRKKMSQHTMPKRVSNDQKWSNWKPKFVHSKKHPALSVEKMKRPFERVTDSKLEIAELQKKILEEELLNKRKQWAFEEEEREHKREMWALEKKYFLNKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZB2</accession>
    <name>A0A835KZB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000413">
        <property type="protein sequence ID" value="KAF9408024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47819" checksum="3CA7A1101AE17289" modified="2021-09-29" version="1">MPLNSEDGGEMGLSNISHSFKRVVGSRRCHVRPRPQIPYPSSRIKDTYSKSSVSAAPRVSAYSKSSVSAAPRVSAYSKSSVSAAPRVSAYSKSSVSAVPSVSANSKISVSAVPKEPAYSNPTKSAVPKAPAHSKFSVSAVPKESACSKSSASTAPKKPIYSKPSESPVLEKSKFSKSTEPALISTSCSTPRSKENIIYKITSNSTKRYVPHVSLRTPLNNRSLTFLVDTGSAVSLIKSNAIKSMPVLQNEIIHLKGIDNTNETIPTSDIKRDNEAISYLMSHQIKRSALLGVIGTLSKKLFGTMDEEDAIRYDNAIHEIQTDTSKIASTLKENILVTTSTLKSYNNTLETIKTNEHELNVAIDALYEDIKNLTYISKELGIRSRILELTSMLENSLLALSFKVEDIMNSVMFVIPPSWQKGLISSFAIEIYQTSLASVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZJ9</accession>
    <name>A0A835KZJ9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000275">
        <property type="protein sequence ID" value="KAF9410151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZJ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="223" mass="24112" checksum="DD72C5B1F9779B13" modified="2021-09-29" version="1">MNSQHPEVEAATGSKASRPRRGRPSGAKRIPLTLEERRARNAQYERERRKDFAAAQAELAGAAGCDPNVIASCFEQLGPNFILSDGEDDEPHSRKRKLSEETFGDDKCWRPGEKRMPADLASTADLADAGPSSSPNTLQTTTDGELSLVYITPPSPLLSQPSPSESTPLRLEAVSEEDISLPSLTPPSGSPPLQLESKDVAELFSQDELRKIYGALNSVDQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZQ2</accession>
    <name>A0A835KZQ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_012343</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000442">
        <property type="protein sequence ID" value="KAF9407723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="46"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="370"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="664"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7041" evidence="13">
        <location>
            <begin position="953"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9407723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1327" mass="147846" checksum="9E4D40F6259AD06A" modified="2021-09-29" version="1">MQGRFHSLVFHQYSTLIRQVVYSNKICNRSVVLSYKVLGEGVTEEPPIFLLHGLLENKKLWESIGKIIFNLTKRSVVAVDLRNHGDSPQVNSHKYEDMASDLLNLFKKLGVEQASLLGHSMGGKAAMCLALISPLKIAGILVVDISPVSTSVHYRDEYPQILTAMKAVDFKNARKENHAKKEAENQLKTVITDNYLLNNIIANIKEKTDQTIGWTVNIDVLLKHIPYIANFPKSMKGKKYFGPTLFVGGQLSELIPPDDLTYIRHYFPRAVITYIPKTRHYVHIDDPTSFLELTISFIRTHHYKRHFKPPALLNGMDIFNITVRKIGIKCQHLMKPIYNQRTNAVVREKCTAINVAHRIHGPSPSPGSLPIIVLHGCLGSKKNWEKICNYITVSTYKTVIAVDARNHGDSPYTANHNYHSLAADVSKLMSKFSIEQSIIIGHSMGGKTGMVLALTEPSKVASLVVVDTSPVSIPGTLADEYPKIMKAMTTVDFKGMDLESARDLAKNKMMQHNLFHSEHDLQNILVNIGKLADKSIGWKYNLKTLMNTVDDIISFPNMFGRTYKGPTLFVAGRLSYAIPPEDLRGIRKLFPGACLVYVEGVGHHVHAEDPNTFLDTITQFLSDNSKIQTIQKQYSLKQIIRTRASVVDLAHKIHGPGLTPDSEPILVLHGLLGSSRNWQSMCKKITEYTNKPVVAVDARNHGDSPHSDAHSYLDLAADVSQLMTKLQIKRASIIGHSMGGRTGMALALAEPSRVANLVVVDISPVRKRTSTLSVFFPKLMETMKSVDFKGSDTLNKAKNAAKSKMVESQLFQSDQEMYFILMNIGQLPDKSFGWKCNVEAIANNFTKIASFPNLAGKIYNGPTLFIGSKLSSFILPEDITPIRKLFPKAQLVYIEGAGHNVHHDQPSAFFDTVVQRQIPARQQKNMATEEYSDAHGVITSKSDVATISLPARLPPFWRQNPRLWFAQFEAAVAASKIGEEQKFNLVMLAAMADKMMEHFEPASINAVSTAATCQENLQISLLSKQIEKLSLEIAELRTNQQNYQPTSENAEAVDLAYASYESTSSQKSAERPPLVILHGLLGSKNNWNSMSKAIHRTTGRKVISVDARNHGDSRHASQHTYIHMAHDVMKLLKKLELSKVSILGHSMGGRTAMVLSLLCSDMVSSLIVVDISPVKTSPQIFSMANLFDAMTSVSIRPGIAMSKARKLADEQLKMITPDVNLRNFLITNLVQTNSGSYTWRVNISALKDNFQSHISCFPSNLRGLQYCGPTLFVGGSLSDYIGKNDLKEIQEYFPLAELVFIDGAGHWVHSQKPEQFLETVCKFLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L008</accession>
    <name>A0A835L008_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000399">
        <property type="protein sequence ID" value="KAF9408201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L008"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032615129" evidence="1">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="298" mass="34004" checksum="1452DA8B44D79774" modified="2021-09-29" version="1">MITLTLAIFVTLSLFSLDQVESAKQQVQLSDSYLPVAMQIISHITDQMAFEDRNDDAIPQTRSIRSTVSPKPYSRFSWHPQQHRFVLLPVEHQAQYTILQPQEKRTEEPLLAIHEDQIKPLLEPSPEAAPYLPPHYDVKVSSRSDGYLIDDISEESLQYLSDDVREMIKMAKDPHDDKVVDVWDGVRQGNHPVTTKAKLSASNLRLLLLYDLLSRDAKRQRLSDYSGFSPDVMKALVASSSGGVREQLKMALSKMVERHDCGHEYANNRAREMVEELGKDESGMSTDLRYLQPLVYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0R6</accession>
    <name>A0A835L0R6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0R6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF186">
        <property type="entry name" value="NEUROCALCIN HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="219" mass="25018" checksum="1716C823B51EB94A" modified="2021-09-29" version="1">MRECPEGVVQEESFKDIYAKFFPHGNSALYAHYVFKAFDVNCSGAISFRELLVTLSTLLRGSVYERLRWAFRLYDVDGDGAITRQELAEVVVAVHELLGRRAPPGSPAARLDDAKANEQVDRVFRKLDLNQDGVITIEEFLESCLKDDVITRSLQMTVAKRRSVRTAHRRCQCAREAGLLRAAAAWLRGRRYAHYLAALDDFYSRVVRPRLRSVLLLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1H2</accession>
    <name>A0A835L1H2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000358">
        <property type="protein sequence ID" value="KAF9408829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1H2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="26469" checksum="707DCE40E530938A" modified="2021-09-29" version="1">MTFDFDFKVPKVLKSVKYSLAAVNGVFLLTGFVLIIVGITSLVSFSQYEPLLTYRFFNVPSFVISTGVIIILGSALGFYSAISQKFYFVAGYVVLLLVVLIFEISMIITAFNLTKHVLSEIRPVMAQSRLTYGTNINVNMLWDNLQMDFKCCGVGGPGDYQLTQIPVSCCYIEYGTVSPFECGANAYKDGCAVPLAEWLSFKTNVIAVTAVVLCCVQVLLSLMGGYLAYRSKFEVVELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1K9</accession>
    <name>A0A835L1K9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_014325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000979">
        <property type="protein sequence ID" value="KAF9404451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1K9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005099">
        <property type="entry name" value="PRK06529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="3">
        <location>
            <begin position="484"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9404451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60483" checksum="69C260730A111B5A" modified="2021-09-29" version="1" fragment="single">MKDGLYYASQFKEKKLSVPEWIDDRERKLKQLNPKLNAFVDWDAYAAKKQYESMKVANGPFYGLPIPLKMLGQNKAGMKSTSGSRLFTENLSVSTDNFVKKLEHLGFIPLGKTNAPEFGFKNISEPMIYGPTRNPWNLDYSPGGSSGGAAAAVASGLFPIAGASDGGGSIRIPASFSGLIGLKPTRGSMPVGPNGWRGWQGASIDFALTVSMRDTETLFYYLRGTETTAPYQAPKVEWTHHKATEQKILKIAFLTESPVGTPVSGEAKKAIHHATNFLEKQGHEVTEISYPVNGRQLIDSYYLMNGAETAAMFADIQHEIKRPVTIADMELMTWGIYQYGLKLPASDYVRSLQLWDQAASKMEQLFKEYDLFLTPSAAAIAPKIDADLQSEQIRKSLAQAQTQSASQLKDLVYAMFEKSLTITPYTQLANLTGQPAISLPTHIADSGLPIGIQFMASKAACGGSQDKTAGKDESFEKVEKAKKITVATSGTLFPSSYYNDKNQLTGYDVDIIKEVGKRLDLDVVFKEYNVDGQIASVEKGEADLAANDFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2L9</accession>
    <name>A0A835L2L9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012603">
        <property type="entry name" value="ARID4A/B_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08169">
        <property type="entry name" value="RBB1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="8">
        <location>
            <begin position="131"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1378"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1452"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1398"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9413112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1554" mass="171400" checksum="A43E3FA5F436FD6B" modified="2021-09-29" version="1" fragment="single">SEESEGSGSGRRVKADVEPHVGRVVLVEAGGGAERRRPHQPAFPALVVAPTAQIKVKEDYLVRSFKDGRYYTVPKKEAREFRKGSAPLEWAGVDAALQYLNNAVLPPHWDRDALFNEPRNTSDDSSDDEPREEKDHFVAQLYKFMDERGTPLNRNPTIANKDIDLYRLFKRKRKLQAIPSSRCVLLRSSSTSNDENCRLSDSSTVFPNRKQTGRHVVEKLGGYNRVTNQNQWKAIADKMGFHPVTTSITNLCKQAYKNLTSTDVICVRVPPRFLHSYEDFYRKLGVTLRGKDKDSDKSETDKSEKSEKEEKLEKAEKVKEKPSQPRTSDGEDSADNQPLIVTAPNTSEEKEKVVVKPRSQSKGRTITPVKTESHEKRTPKRRPLSSKSEGVSAGTSRASRRPHASTDSDSSGRASRCGPIKKMQSRRSQSANSASSGNTIASNSSKRPRKRKNTEPTNEPTPRSGVSNVKAQVGDKLKVYYGPTQSESKVTYEAKVIDKSATGDLLRVHYLGWNTRYDEWIKPQRIALNVTQHEQRNKKGSGMSRRVRKSSARSDTDSDSESDDDVKRPPKKSDDKSSSKTPSRSKDVKSSDSSGSSKPRKRPVRTVSTPTSVSPAKKPRPTAPGHQGRDYDLNEIRSELKGLQTVKQEPEDSKQDATDTDEATPSQSTAPPPEPMQQDKQPEDVYEFKEPEPFELELHDEKKKRTHRIFDDISPSKYTSTLSKSLSEEISEDPMRPRPSSLRSPSLSPFRDFGVTRDANRQSPEDDSKDGLFSLDDDSFPGDGSSGPTFEGFTPAKNQETYSKKSKVSKLRELIDDSPDSPADDEQSSDDEPEDIPVKEEVRQLTPTLPVVEEPKTPESPVKDEPMEPEVVAPVKEIVIEEKDSKEHKEPKESLPEPPKTPPPQMKPDSPPPKPTAAPTASIAITPVPPIITVTAAPTPEPVVDHPEKAKKEEPVIPAPVVVPPVQQPKENPLKLKIEKKLDPVPIEPAILKMQPPASPLMDTEEDKSEPDSPARIDVLPEPPPGFLLQSEGPKIAEKLLKAISSAKRLSMSPPPMEDRPVTPKIDAIKPIKPEHKLSPVMCETKSLKAETIKPILKPETIKKVTPAEPAEIYGESSSIVEVKRDALEGRKKVEEAVAPRLHSPLSCLERRSSAAELAGSGGPGAPGPPAVCGLPGVPSVPSVPVVPGVPGKNNKVLSDTIQKLSSQINQSAAAVAATVPLPFPSDERTDSSDSDDSDRRLIIDKLVVDEWGSSERSSPAQASHSHSLPPMGSHPSLAPLGSLAPVAPSTSMTLGARALHAGKSPGEWSAGESLLMLEDACKNERKHISRCCCARRLSRARPRPTPSLRPPGSAYTCPSLQHRLIITLKARDAWPRGRALVDNTPPTTPDSSLDASPPHRERRISERDSPSERKEDEEDSRMNDVSGLDVEKPHDPTWDCSTRINVLTTRLADLRKAYHSVKAELAAIDRRRKKLRRKEREGKVDKKAYKLPSVLSSNLKKELLYDALISLSVYCNLVKRVNKNYFLGLFSLSTLKNSPLIYPTVKAAKAACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3B3</accession>
    <name>A0A835L3B3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3B3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49919" checksum="1F71D3BCE132D7DB" modified="2021-09-29" version="1">MLYVGICVFSDFDGHLGMKVEQVLFVCALVGVARAGLIAAGHGALSSQSIVLGAPALAHGYGGYAAAAPAFGLGHGAVVAHAPVYRAPYAHAAAPVEVYAHPRYQFNYGVTDGHTGDQKSQWEARDGDVVKGQYSLVEPDGTVRTVNYSADDHNGFNAVVSRHGHAAHPAAHAVVAAPALGHGHHEISHGYHGGEHIVHQQPIHYVPIAVHHQAPIAVHHEAHIVFVIAVAAVCAQEHHQHGHEQGHAYSSQSIIRHDISHGHEDSHGSHEIGQGYHGDSHGNHEISHGYHGDSQGHHEISHGYHGGEHIVHQQPIHYVPIAVHHQAPIAVHHEAPVAVHHAAPIAVHHEAPISVHHEAPAVHHVESAHHEKEHHHGEHHVDYYAHPKYEYEYKIEDPHTGDNKYQHESRDGENVKGVYSLHDSDGSIRTVEYTADKHNGFNAVVKTETKHGHEHQYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3G6</accession>
    <name>A0A835L3G6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3G6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="16243" checksum="2AB97A8C93F0697A" modified="2021-09-29" version="1">MGQIVVEMYWKHAPITCRNFMELVRRGYYNNTKFHRVIRDFMIQGGDPTGTGKGGQSIYGPTFDDEIASDLKHTGAGVLSMANAGPDSNGSQFFITLAPTQWLDGKHAIFGRVQSGMAVVKRIGLVECDKNDCPVDDVKIDKAYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3G7</accession>
    <name>A0A835L3G7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003007</name>
        <name evidence="2" type="ORF">HW555_012541</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="186" mass="21038" checksum="361093B1950C92E1" modified="2021-09-29" version="1" fragment="single">LAKVRPVGAHVGKSFVPLTEIPPPHVPHPNRPHPDAHKDGHKDGHTDKSGRRHLEDDCIKKPAGKDVIEGPKVDIFPDYYDDKIAKTVATVIFPDHIDHKHYEVTTQVPYLTLGPIEAIGYHPSTMKSEHPSECEKIYQDHLDEQYTEESKDYSEESLEMARLPLSPPNDPSAEERVEKLYSDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3U2</accession>
    <name>A0A835L3U2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3U2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="36388" checksum="876D3225DF856DB6" modified="2021-09-29" version="1">MVDTPRATLSEVFERPVEWRLQHQRDVVVVLRLLLALPAAAALRSLRHPILRRRLLLVIVLTKVLALLAKILTEILPLLTVVMPLLCVVLFVLAVIWLPKLLALLSTLSKAVLSKLWSSVLLGRLMMLVVLRLLELLLDVVLQLVLVVVVLLVPSVLLIYLRSWLLRELVVTVLSKLTLLTKVGTLTKLAIMPKMASRGELTVLAGGSELVEWAAHLVANALLADLGVDEILADLGAGELLADLGAGEHLVDLDVGELLVDLDVGGLLVDLDEGERRVELGAGELLAGQVAGGMSVDLAPNEVQVDLDVSERLAVLGVHAPQVSGVLLVELAANAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4M0</accession>
    <name>A0A835L4M0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NudC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4M0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NudC N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="17288" checksum="2859068F425EB5D1" modified="2021-09-29" version="1">MANDPERFDTMLLAMAQQHEGGVKDLLNTIVGFLARKTDFFTGGKGGEWEQQKKEQERMAQDFEPASVTEITDQEAVKIQEDIDKEKKNQTEVGSGDGTPVEPEQAAEAEEEDDPKEKGKLKPNSGNGCDLENYRWTQTLEEVEVSEIYIESNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Q4</accession>
    <name>A0A835L4Q4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_005243</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="JACKWZ010000066">
        <property type="protein sequence ID" value="KAF9417736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Q4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000147">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9417736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122126" checksum="9852B58BC20CE027" modified="2021-09-29" version="1">MGVQLEFSRRLSVTNKVEGLSGSKADLQHRREVFGSNLIPPKPPKTFLTLVWEALQDVTLIILEVAAVVSLGLSFYKPSDDPADVAHLDEEEGHYQWIEGLAILISVIVVVIVTAFNDYTKERQFRGLQSRIEGEHKFAVIRGSEVRQVPISEIVCGDICQIKYGDLLPADGILLQSNDLKVDESSLTGESDHVKKGEAFDPMVLSGTHVMEGSGKMLVTAVGVNSQAGIIFTLLGAAVDKQEKEIKQMKKGDEDATLPASGNSHGANHARPDDNHVPATSDKPPPESSHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILVINFCVHTFVIEQKPWKATYINNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVTPNFRDIPQEVAETMVEGISVNAAFTSRIMPSQDPTGPPMQVGNKTECALLGFVLALGQSYEAVRERHPEESFTRVYTFNSVRKSMSTVIPYKGGYRLYTKGASEIVLKKCAFIYGHEGRLEKFTRDMQDRLVRQVIEPMACDGLRTISVAYRDFVPGKAEINQVHIDQEPNWDDEDNIVNNLTCLCVVGIEDPVRPEVPEAIRKCQKAGITVRMVTGDNVNTARSIAIKCGILKPTDDFLILEGKEFNKRIRDTNGEVQQHLLDKVWPKLRVLARSSPTDKYTLVKGMIESKAFDTREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAIQDSPLKAVQMLWVNLIMDTLASLALATEMPTPDLLQRKPYGRTKPLISRTMMKNILGQAIYQLFIIFSLLFVGDRLLNIPSGRGQALGSEPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVFQGLFTNPIFYSIWIGTAASQVVIIQFGGMAFSTAGLSIDQWLWCLFLGAGTLVWGQLVTTVPTRKIPKRLSWGRGQPDPETIQPGPDYDPDLDKKPRAGQILWIRGLTRLQTQLRVVRAFKSTLEDLEERLSAHSAAGLRSRLRGPPPDIAYIDADDVPAAPRTETTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5A8</accession>
    <name>A0A835L5A8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000053">
        <property type="protein sequence ID" value="KAF9418597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5A8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF2">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D11, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033023612" evidence="3">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="247" mass="27879" checksum="A29E81651C6ED724" modified="2021-09-29" version="1">MKSLVCLVAVCLLTILPSNAAARSKNKMPNQPIKVYYLPPSPPCRSIIMAAKVIGVDLDLVLTNIMEGQHMTPEYLKMNPQHTIPTMDDSGFILWESRAILAYLANAYGRDDTLYPKNPRQRAIVDQRLNFDLGTLYVRYSALYLPMLFRGEEYDEKKADQLDEALGWLNTFLDGRAFVAGDNLTIADISIIVTITNLEAFGYDMSGHDIPNLMKWFERTKKALEPYGYEDVDVAGAKMLANFLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6C5</accession>
    <name>A0A835L6C5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055303">
        <property type="entry name" value="ATMIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664:SF1">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="39766" checksum="11C11F13B65B14F8" modified="2021-09-29" version="1">MSKMSVPLTKLDIPVNRLTVVCRGCLAESGEMKNIYEWGINDDYFRVTAIETSRRSGISELLCSSCEAALISCKQFQDRCQLSDKILKSSLSARTKNKTQKTNRNQVTCVLQNKRLELQITAPKTDARIRLPCPYNCEENFFKKSDLQGHLKKTHNLPDNFDINMQYYCSETTCVYHVNSNKKKWFSGRKFLNQHIKKVHKTKSFLCNDCGLRFSTETDFQRHSKSCNYVFLCRICDVKYNTNEKLMVHLKRKHPTNQADSKKSFATQIPEPITNDVALHSWAPKDYETKTDEISTQVGFEDLLIQRKLKLVLRIIRTCDGTTIFQLKALDCCPVRAFLDIDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L710</accession>
    <name>A0A835L710_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DHX34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000196">
        <property type="protein sequence ID" value="KAF9412222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L710"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000725">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056382">
        <property type="entry name" value="DHX34_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24485">
        <property type="entry name" value="zf-C2H2_DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="218"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="405"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1167" mass="133179" checksum="8FC75C9153223303" modified="2021-09-29" version="1">MVISALCIGQDLDSICNYGILAVSKPYRRSVGLQVFPSPCSSNYYKRKRSRSRSRSRDRDRHKIKRISVSTSSSKSIEEDFSFTNYKRDLNKIILYSNESNTVVNNLDDFWVFLKKYEATLRKAGKPIIDYGPDEKSDDKTEAFSKFDCIYFTTSIKYVDTVYNDSQRGKLDKKLFIAFLNIVSIYLDFKNKEKFEKLRKLRQAQKDLPVAKYRDEIVAAVKNERVVVVAGDTGCGKSTQVPQYLHEAGFESIACTQPRRIACVSLSKRVAYEMLTQFESKVGYQIRFEKSKTADTKICFITEGLLLRQMSSENLPNYDVIILDEVHERHLMGDFLLGILKCLIHTRTDIKLVLMSATINIKLFEDYFSAESAVVIQVPGRLFPIQLQYKPILMDDKPTRDDRLDPQPYVQVMQLIDSKYPQITTICDAAQQYAEKSKNWIVLPLHSGLSLAEQDKVFDYPPEGVRKCIVSTNIAETSVTIDGIRFVVDSGKVKEMSYDSTTKMQRLKEFWISKASADQRKGRAGRTGPGVCYRIYSQEQYNGMDDFSTPEVSRVPLASLLLLMSSLGVSDVRRFPFLDTPPEDAVENALLELKQHGALTSNEKLTALGKALANLPVEVCLAKTLVLGVATLPPHKLDSALALAAALGIRSIYTTRAHRDFECENARRPDESDHGDPLTLLSLYCAWLREKRDTRGGRAWCRRRGIEEQRLYELTKLAAQLRSLLQTPEPESMSSAERALRHGQVKQLKDARRQFKQKAANDLKRKKRLKMSSWEIIDDNANEDEDIDIRDVEFRLTNDAQRIQSLIAGSSASSGRDLVMLKLVLCRALYPQVAVADGFNHHKSVAEQLYHTWSKPFVFLHPTSYFGKQSRVLQLTEADILSDMRELNAVGYEGKLPVSSKHQILCYLSLLETTKPYIVNSMRMPAAQTLLLLAHSIDTNIGFTRIVCDSWLLLEFPFPETGLKLLLKAVKLRQRWDALVNRRLQDANPTKSVESELEKQKQEKISYEEVQHELACDMSTYMTSEVYYTIKRLLPGDLKVLYCGNDEAHPSIDPNPFDENFVCRPHEKKGGVVVDSVWSAKNYEDMYNIPWTCPNCELTVCLSPLERLQHQHFTCSQKEVKTNKEDAPKTSREMKPNAKEYKCETCEQTLYLTPVEILKHKKGCKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7C4</accession>
    <name>A0A835L7C4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7C4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000138">
        <property type="entry name" value="Homeobox protein prophet of Pit-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF520">
        <property type="entry name" value="ALX HOMEOBOX PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="22064" checksum="6919BFA8F90EF6C6" modified="2021-09-29" version="1">MAEGAFKKLKPEPGGGSGGVSGGASALSPALGPQHAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPAHHGSYEELQKDIFSLSQMGGGSYPMPQGFSMGHGANMSAVGMRQDTMGMSAEDEWYNKSLSALRMNSGHHANLAAAPMLQYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8F9</accession>
    <name>A0A835L8F9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_016954</name>
        <name evidence="3" type="ORF">HW555_004313</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000822">
        <property type="protein sequence ID" value="KAH9630416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8F9"/>
    <dbReference type="SMR" id="A0A835L8F9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9630416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="144" mass="16373" checksum="615855DC0F9D5354" modified="2021-09-29" version="1">MANPSSGVVVPRNFRLLEELEQGQKGVGDGTISWGLESDDDMTLTHWTGMIIGPPRTPYENRMYSLKIECGTRYPDAPPTARFISRINMNCVNSQTGLVDNRQVPILARWERDYTIKTVLQELRRLMTLKENMKLSQPPEGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8K1</accession>
    <name>A0A835L8K1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8K1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052296">
        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
        <property type="entry name" value="AGAP007109-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="483" mass="54814" checksum="DC8533F4C680FBA7" modified="2021-09-29" version="1">MTMDVQNNYQNYKETSPDSKDTNLNIESARTSQIKSEMQSTVLNSGKAAKRSFDVAFLMMPDEKVRPKPPERQLRVSKQLFHNEEWEQVPKRMPDIYKHSDYSSDNTMDLKDHDDDRISANNNISPSFGSDINIDVGTDEYPSKSMYCSDSDNSERSRSRPNSNESAARQPKFLPEYKNKIFDDPTLITMQSRARYERYSEKADNMSPKSAFTKVSNYSMRSPNPSVSPDNLLYQNSVSPPLSAASPPSSSFNKTPGFNNLLTPAHLINGSNFFKGQNVPPSSPNYAETSMSQRQSGFNKNLEYQDKPETKTPQMSPNKLNFLPFRPEIPYLQAGSSYPFGVQNFQSPNPDFMKFPVPPRENPLIANPAAAILSTLLPPTLAAFSLPSQNVCAKCSISFRMTSDLVYHMRTHHKSESAIDPHRRKREEKLKCPVCNESFRERHHLTRHMTAHQDKEGDLDEVPAGHKKSKQFYPHNGSSLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8X6</accession>
    <name>A0A835L8X6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8X6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9420946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="472" mass="52426" checksum="7A05515D64588928" modified="2021-09-29" version="1">MSNKTNRKVQYLAGVCAAFSFTFTGATLAWSSPAIPKFKSGEANVVITDTQTSWVVSLHSAGALLGCYFGQVLNERAGRRRTFLGSAVPGLLGATLLLNTTMPELMYVARFMMGLATGIIAVVTMIYVTEISDKEIRGALGMTVQVMNNLGSLTVYSVGPFVSYKTLNCIILIIPICYVLLCLWIPESPYYHLKDGRIEAAKKEFMRLKGNQDESLLEEQMNVMRAHVRESMENKTTLRELLTNMRYRKAVYIVTGLKLLQYMTGILVIQSYLEPIFRQSNFVSGPIASIVYGFVQLGAGISATFLSRWFGRRILLSISCLGVSIAMTLVGLYFFLQDTIQVSVETSRAISWMPLVGILGFNVLYAVGVGNLPYVLQAELFPVNVKGVASSTATMLACILSFLVTKCYQQMKDACGHYMVFWSFAFIGYVGVFFIYFFVPETKGKTLEEVTTNIQDPQPEEQALNTEKNEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L973</accession>
    <name>A0A835L973_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000118">
        <property type="protein sequence ID" value="KAF9415087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L973"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="47713" checksum="4679A840401272EA" modified="2021-09-29" version="1" fragment="single">MIKIDLHKGSWIGSVHGIAGLPSVFLPFIMQNQGRRFAFILSCLFIMSGWIITYLAQNIATLIIGECFHGLGTNCLITTTFLSITEMVSPIYRNSCLLLYGAVQAFGISSAGILGRYLHWKTIGIIMGSPVLVALLIGFAWPESPSWLAYKRRFSECEKCFVKLRGTDADSKKELKALLNTQREDVKKTSGFQDLRKTIVSRDFYVPALHTCVLLNVLYWCGGMPVIIYSSDMIIKISGKMNVEVKLFMDIVFFVGYIIATVLVRYFSSKKVMLFSLIGTTTCMMGAAIFSYLSVNLNADFALYCLMAFQSFLCLGSSCIGFSLTSEIMPVKYRGLGGSLYVVLICIFHSSCLKAYPYLCLFLNIWGVFLIYAIYGTFSIVFIWKYVPDTTHRTLKEIEDYYAFGCFKDRDDDDETLSKAMIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9T3</accession>
    <name>A0A835L9T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF190">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="26614" checksum="178F26AC90E9F223" modified="2021-09-29" version="1" fragment="single">SVVFRVKRHPQVAGFEQCVSFGAFSSEQQEVVYNVFCLCAMYFLPLIIITVCYVCIFCEIHRSKKRMHRSSVGHVRLRRSDRRVLERARRRTLRMTVTIVAVFALCWLPYATITMYMVDRESAARLSPRVQDLLFVMAVSNSCMNPLVYGSYTLDIKGLLRRLIKKTCCHSSAASDTIGIDGSGSSSIKNRNVNLETPLMKSGNKVRTRLGVRFAETSLTAVPSRLEVPKVVRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAV0</accession>
    <name>A0A835LAV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAV0"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="274" mass="30142" checksum="378DC44E3972CDC1" modified="2021-09-29" version="1">MTTLGNSARDFNKVGTIGIIGGSGFDDPTLFENQVEKEVTTPFGNPSDVLIEGQIKGIPCVLLARHGRKHQFQPSDVNYRANIWALKQVGCTHILATTATGSLVEETWGRKCTFYDRTEGGPKGVCHLPMRPAFCERARNAMIVAARARGYRHHETGTAVPKYHFFCRFSSRAESLMHRQWGGHLVNMTTVPEVVLAKEAGLSYAAVALVTDYDCWRENETSVSVSEVLAMFAKNVKKAADVIIDAVQVLAAETNLEYLGAHKELVSSAIMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBG4</accession>
    <name>A0A835LBG4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBG4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="87" mass="10298" checksum="F6189B7F4A17723F" modified="2021-09-29" version="1" fragment="single">VTNLFILKFSSDQQLANIDPRLKINMDPFAHRHLRPEMMFIREELRQAKWQTLAVRRTALKKLLLKDFMEEDCELRNIGLAYAPSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCU2</accession>
    <name>A0A835LCU2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCU2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032677768" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="108" mass="11771" checksum="D04E8C37A4B9EE45" modified="2021-09-29" version="1">MISSVGIVLLICAVAVNAQSQCTFVQKGETNGIPYKLDPVYLQPGTRDYKVNIPTLPQCVNREIGVTANICDEDVAPSGTIPEFNTLLVYRLGNYQHIGVVSITVYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDK6</accession>
    <name>A0A835LDK6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDK6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16578" checksum="0463DF66BBFB7E7E" modified="2021-09-29" version="1">MWLKKIAPKSFLGKFTLQKGSLIIGIITLIISLICVLSFAVEILYYKDCKTCTDLVMHNAYSFSIHAVIYCIFMIFINIWFIWGVKNEKSSVVLSWVVVTGLWWAQSLVLVIVLLCMYITDTSIAWMAALLGAIVAYSKYTIFDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDZ8</accession>
    <name>A0A835LDZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDK5RAP1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Potential regulator of CDK5 activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01574">
        <property type="entry name" value="miaB-methiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="75"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="217"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="564" mass="64580" checksum="49E86C40DC6C1684" modified="2021-09-29" version="1">MLYIRRLHRLSKLISNGSSITCRCYSDTQRLTIVKNKIKQGPGLKDFIIESSEPAITDRPYIPYLLENNKITAKRKVFFDVYGCQMNLNDTDIVWSILKKEGFEKTEIEEEADIFLVMTCAIREGAETKIWHRLDHLRGFKRRAKDRSVKIGILGCMAERLKEKLIEKEKAVDVVAGPDSYRDLPRLLALTENGQTAVNVLLSLDETYADVVPVRLNQDSVSAFISIMRGCDNMCTYCIVPFTRGRERSRPVSSIVDEVRQLADQGVKEVTLLGQNVNSYRDVTQSTEKFDTHLAKGFKTVYKTKKGGLRFADLLDKVSAVDPEMRIRFTAAHPKDFPEEVLQIISERPNICKLLHLPAQSGSSAVLERMRRGYTREAYLQLVDEVKRTIPGVGLSTDMICGFCGETEEEFQETLSLMEMVDYNIAFLFPYSMREKTTAYRRYKDDVPDHIKKERHNRMLEVYRRKCQQLNEAEIGNTHLVLVEGIAKKSGNILGRNELYLRVVFEQMDVLAEDGGMRPVKPGDYVAVRIVGARSATLRGVPLYHTSLCDFYREKQWGERRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LED8</accession>
    <name>A0A835LED8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl synthase</fullName>
            <ecNumber evidence="3">2.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LED8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="100"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="319" mass="36038" checksum="FAB4DC46AAE8B094" modified="2021-09-29" version="1" fragment="single">FQRCKHTSKLDAIREKLREGPSFADFVSEDRPKDWEDYEGKLKREKGEAERLRLPPWLKTTIPTGSKFTGIKKQLRELKLSTVCEEARCPNIGECWSGGKHGTSTATIMLMGDTCTRGCMFCSVKTSRRPPPLDPLEPHNTAHAINQWGLGYIVLTSVDRDDLPDGGSAHFAETVREIKRQNKDILVECLVPDFRGNRDCIQTIAECGLDVFAHNIETVERLTPFVRDPRAGYRQTLKVLQTAKEVNPDLITKSSIMLGLGETDEQVEQTMKAKFKEWEVRGNELGFLYTASGPLVRSSYRAGEFFITSLLKDRKAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEJ7</accession>
    <name>A0A835LEJ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 10"/>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEJ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="225" mass="24996" checksum="1BD7620291593E76" modified="2021-09-29" version="1">MYSFDRDQPFTFQIGVGQVIKGWDQGLLDMCVGEKRKLTIPSSLGYGERGAGNVIPPHATLHFDVELINIGDSPPTTNVFKEIDADADNMLSREEVSIELAFQAMDTDGDKELSREETAPQNVTLSATHTHGYVLLSTAIVNVSDINGKLHKVRVLLDNGSTSSFVSEYLKKQMVPSDGAEMSDDIKQMLESHDKLVEEIFQHEDKDKNGFISHEEFSGPKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFD4</accession>
    <name>A0A835LFD4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pulmonary surfactant-associated protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pulmonary surfactant-associated proteolipid SPL(Phe)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001379</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFD4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000008">
        <property type="entry name" value="Pulmonary surfactant-associated protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00162">
        <property type="entry name" value="SAPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0767">Surface film</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032594831" description="Pulmonary surfactant-associated protein B" evidence="12">
        <location>
            <begin position="22"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="14">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="14">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="403"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="554"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="645"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="794"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="882"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9423075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="974" mass="110275" checksum="1DED480B1CEAD4A6" modified="2021-09-29" version="1">MTNTLVVCLLALFCCTDLSFARQVPKECAKGPAVWCQSLKRGAECGAVGHCTSTVWEKQTETVSHNDVSNKFVRLFRQLKDVRELINEDYLASRVASECKDLPYPGVSKICKENTAYLQQYINHVLQSETSPETMCRLIGMCNNMKVDNILSMDKKKPVVPKVIKHKDHLLGSSQCTWGPSYWCSNFSTGRECKAIHHCVSKVWPNMDLPEDTDSVCKICTDMVQQARDQLQSNETQEELKEVFEGSCKLIPIKVVASECMRLADDFVPELVETLASQMNPQQVCSVAGLCNSARIDDMLDEFNTQLNLRVECNHCQSTVGVLRKKFDATSYDDFLVGLLQMCGKMDSLSDSCSMLVFKYYENILEALKKDLNGESVCHLSGQCTYKYHQHDDFTFPDFTPTDDVPCELCEQLVKHLRDVLVANTTEIEFFKVFIGICKQTGNFKDECLHLAEQYYHVIYKYLVEELNSKEICAMLGVCGNKTQNVPIAPLVPGEISVKAKLIGGYDMDKKQTTEKLARVPITKQTNVRVMQESTSVGPLPIERMFVSVPQPQGKAACSFCQYFLHYLQVEISDTRTEDEIFQAVDKACDKLPHSVNDECKQFVTQYGPAVVALLVQRIDPATICPALGICPQVGEVRRVDINSEKSNCPLCLFAVEQLETMLKNNRTEQNIRIALDNLCTHLSTKLRTECVDFVDTYAPQLIEMLVANMDAQEICVFLKLCKDEVKDPLKITQNSIDKFHQKPELMADRNNFRGKSLLPTTMLVATHKDHDIETNEIFDNTVNGREVRPPMKQKTVCVICEFVLKEIDDQIKDKHNEDEVKHVIENVCRRMPKNIRSECEQFVDKYADMVISLLAQELDPEQVCEELKLCDRPSIVAAKEEILDCAVCEAVVMAVRKVLSNDKVDRNIVNIVEKSCELLPAKYNERCHSMMEIYGDSVIHLIEEFGTKGVCQKIGLCSSSDAAYVHIRRPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1K0</accession>
    <name>A0A835G1K0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-hairpin-helix DNA-binding motif class 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000964">
        <property type="protein sequence ID" value="KAF9404487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1K0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF23">
        <property type="entry name" value="5-AMINO-6-(5-PHOSPHO-D-RIBITYLAMINO)URACIL PHOSPHATASE YITU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="64194" checksum="BFDEF2238861C785" modified="2021-09-29" version="1">MVNFNGALVHMPEKQWANEKETGIQRDLVFEILAQKKALNLDFVAAENKETFFIDSLDYFDSAFFASDATADNLLTAKNLVSDPTSMMVRTSQDQAKMVSDALMKQYGDYVDVRTWGGPTPILEIVSKGIQKAKGVEQVANYLNIKRSDIVAFGDEHNDEEMLDYVGWGVAMKNATAQIKAVANDVTEKTNDEDGLADYLERKSNSIPRATFTPQEVADLTMEFYMRNYIEGLFLSSAIIKNVDYTSELLIKTLKILRYEKGFKGYIHVKAIPGADEKLIEELGFLADRMSVNVELPSRESLKLLAPDKDPFALYKPMKQITQTTNELAQFPALKKGKSFVPAGQSTQMIVGASPESDHSIVKIAENLYQKYELKRVYYSAYIPVNQDSLLPAVTTDPPLLREHRLYQADWLLRFYRFSADEILSAEKPNFNLYLDPKANWAVQNYDQFPIDVQSASYERLLRIPGIGPKSAQNIIKARKYYQLHLSDLKKLGVVIKRAQYFISCNGATQPGLIHDPEWVISSLISSRQYETLKKVNSQSTQEQLTLFDVERFEAVKRKEQPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1N6</accession>
    <name>A0A835G1N6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000630">
        <property type="protein sequence ID" value="KAF9406174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1N6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="248"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="594" mass="68298" checksum="D5DD579E561BD126" modified="2021-09-29" version="1" fragment="single">KANMGRPTKRASRMRQRRLNETSEDHEKRLSQSRKTTAKAILNENSEKREKRLSQMRTYMKKVLDSENSKRRTYRLGLIQDRLSNETEEQRTHRLSLISDRLSNETQKQRAHRLRLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLGLIHDRLSNETPEARLNRLNTMRQTSHIRRDITNEQSFQTAINVFADVSCDVCKKNIYPQQRFNLRPNMYNTLLPEELIALDKITTCSRCNNHIKKRKIPPTAYWNKMMPAEIPPELANLTSFEERFLCRIVPFLKIMKLNRFSQNWCKGQVILFAKDVVEIADQLPLTPHQAGLILVYVIINDNKAILRGSFHQGDLRFNSSRGKQCTGIAAVACVAFTVLDPNNWSKSDIDYILIIGDKYYNDCIASRNNPAFGEMNPDYLAVTDLMPSLVYNRQNIAITVLEETNINGHLDNDNSSDGFPNLRNALRSFFTEYSSGILTTNAISVAVHYRTSYYYLFDSHARGAKGSSAPINGAACCMRFTDLDDLHTVLRRNLYVSPNKPSGGNLRDNLNVYSLTPLVVAVDNQMRSFRPISEQSAIEMMESPTFTPSPINLLQPPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G433</accession>
    <name>A0A835G433_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000775">
        <property type="protein sequence ID" value="KAF9405249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G433"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="162" mass="18273" checksum="1B2A97B1BF91C994" modified="2021-09-29" version="1">MALDMTHPPNWPFPNNSAGSESLLQQDLKNYMVINHLGYGSAFIVKFSELIGSKDIISAAALTKAFTSEADKLIAQGTFSRMGPDIVKEMKKLLNVLVTSDIENTMDLARLSHFIFKNKDQTLEAPVKQIVDYYDKMFKKEEGEELFATLEALERYPEGQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4I0</accession>
    <name>A0A835G4I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000597">
        <property type="protein sequence ID" value="KAF9406418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4I0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="504"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="761" mass="89048" checksum="AEDAFA8FCC198CE5" modified="2021-09-29" version="1">MSGGNSKNKARSKKQEGWEEAGATTVKRARSQNERRQSTYARTTQSRDIHLSMLPDLSENLSNEERTWEEIMQIKAMPVPMNQKRELKARLQNATKLRLQGFEQLQWRQRKVWHRFSIRFSEIVGKLELWQSPMREIEGKFGTGVVSYFLFLRWLLFLNLAISVIIILFMILPKTLLNEINYRCEDFESNSTICCSNYYLTKNLTDSNVFFDVIQGTGWMERTILFYGVYTDQIYSYYIANLFQSKLYYNMPMAYILVAISWVLLSLIAIVKTAAKGFKERLVENEGQFYKYCNLVFGGWDFCIHNDKSAKIKHKGIYNEVKGYLEEEKFNEERQLRTRESQILIYFKRLLVNILVFAILIASGVLIYFTFNYSTDKLNEEMSQISENQNELHIENFNQSHTEKFTLRLYKEGGLFFGQLENTLLEFLPFICIVVLNLIVPEIFSYLIQFESYTPAYVLIITLLRTVLLRLSSLAVLLSQMYTYVRDNGFVCAYNNNDSSKLDCWETYVGQQLYKLILTDFAVQFVTTFFINLPRAFLARHTNSRCFKMLGEQDFYLPKHVLDIVYTQTIIWMGSFFCPFLPIIGTIFYFLIFYIKKFTCLTNCTPSPVVYKASKSKSLFMSVLLLGFIVSIAPVAYSVAEIFPSVNCGPFRGYNNVWEFVVQTFEGFPFVIREFIFRLGTSAFAVPAFAVLLFFLYYYWAVAAANRHMVTVLKNQLVLEGHDKQFLLNRLSAFIRQHQKRCERRNRASFADDDSIRQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G576</accession>
    <name>A0A835G576_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000451">
        <property type="protein sequence ID" value="KAF9407625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="8">
        <location>
            <begin position="439"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="ZAD" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1307"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1335"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="974"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="977"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1025"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1028"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1354" mass="155641" checksum="935E4FFB3AA9E9D4" modified="2021-09-29" version="1" fragment="single">GGIKPGRVTFFVFRRVPEVTGDYFDGFNKSNCSTTSFTMYLPNTKPTASSSSSVAFSTSYERSFNTYTAIRRSVPTAPANIPFKVDSINIDFEEPSAKSRNATTGRNFAAEANVSSTGPPSERKLSARATRTVRRSAAKVRMNSALSTSRQRITRVATAFTPALFQPHSAKLTTGRARRLLITDESRLHADLRNMSPQEELHRAQFRVQNPISVGAKPQLALQDSAQRRPECEQVHCCAAQLVVIELIPHHCVHQFCLLKQERYHVAYQQSHRSLLRMKSLDQRFYRFVLEPVLQYEVTVTAAEELYGELKRILFVVLIKLQALGGFSQVDVQPMPHFGNCWGNHFRKESFFQIFRSVSLSETARSILNSRSVGDCSGTASTSWTVVPLSLAARTSELRCRCRWPRVSPDNVTDKNIKMDPEADITLRAVKFLTSESNNVCRLCFSSTEQQEVSLEDIVTLQRSYLNETLTFVDMFQELNVLEEHSLPQVLCVNCATMTINAYLFKKLSQFSTDYWNKILNRINTTLDQSQTISLNVQTLYYIMKDDENILYTSRKRHTVRNKKTIINKLKEFGKTKQTCYKVKKLKTSVMCEECGEKFTSNCHLVKHMKVHSTSKYPCSQCPKVFATQLQVEEHAERVHYPKKICCPKCSKMFSTEKMLRLHDKLHHVAAICKLCFVQFPSKKQLRAHLDKHEVNKCARCNKSFLNKQTYKFHLRICGNLEDRQPSFFCDICHKGYVRKNGLRTHLKTDHGFGNVLSCNWCGKKFDAISRLNNHIVKHTKEKKFHCEHCGGKFVTQAALVYHTRLHTGERPFPCDMCNESFLSASRRMEHKQRKHFGPTKECQICHIKFITGHQLRKHIQRHYNPHSKLFVPDAVPPFPSYQSVAANTNDKAEQYPNISKLLSIQSMNLTLMFSTAGTLGAEAFTNLSSHNVQLYGLSPVCLRVWYSSASLETNSLLHSFILQNVFMGKAEYCSLCFIATENVQFNITDEILMDTGSTVVLYEIISSVFGNQILDSVVISGIICKECLKTLMNCYKFISLCKNNINELKCKLNSFQKHIESIKEVNCDYKSIFIALNSYNSNFELYYDKHRHSKDKTMLYKRFRTIKKDSLRFFIEFEEQFSSDKKGVVENHAVKKRKRNTALQTIKLTDIAVDTTDLNNLKCKTCLKLYPSALKLKMHYLNVHGPKEYKCSECPKQFISLWRLNQHKQSCHHNVMCSQCGKTYNNYFALRYHEQSHKLKLICQSCGKEYRSQISFNNHIKHKLCNEKRKSNSESKFICDYCKKKYASKCTLIKHINVEHENGKGFVCSWCNKKFGCESSLSSHIVKHTKKKDFECNICGGRFVSKVSLLYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5S8</accession>
    <name>A0A835G5S8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Equilibrative nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000410">
        <property type="protein sequence ID" value="KAF9408061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5S8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF80">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49749" checksum="4FA43367FA66D479" modified="2021-09-29" version="1" fragment="single">WDAADEKAPFLRNEPVKLTPAWEGNNLPNDTLNLKAPRDRWHIIFLTLMLHGLGTLTAWNMFITAKDYFVKYKLASAPAYSEHYLAYVGWASQIPNLVFSWVNVFLTSKGNLTVRIVWSLIMEVLIFVFTIILAMLDTSNWPGTFFWLTMISVFLLNGFNAVFQNSVYGVAARLPPSYTGAVVLGSNICGTLIVFLNWCSVFFDNPRTAAIYYFIGGMFVLLICIDTYFALPLNKFYRYHESLQQQMVADREDNKNANTPHVSRLKICGQAFVQLYNVFIVFFVTLSVFPSVISDISPNVEGFLGDNFVRMTCFLTFNLTATIGNITASTWQFPSPRWLVVFTTLRILFIPFFLMCNYKPADRTFPVFITNDWVFWVASALLGWSSGHGSSLAMMYIGGTVAPENAGTAGMIGAAVLVTGLVSGITFTRLCPIIVTADLWRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5Y4</accession>
    <name>A0A835G5Y4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000611">
        <property type="protein sequence ID" value="KAF9406301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5Y4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="610" mass="71532" checksum="1BB108B358FC7769" modified="2021-09-29" version="1">MSSKPKRARRFWKRKHYRKRKNGPEENSSNREHSLEKSKREIHLEISCIEVSSRLYWDYKARFLLSGIPACLTETLCKHQLNGADRTVKQIPERVESSFKIEYNTNAWYEALEMVQMSITPHQYISPDVLQAIVEIMLNTQENVCEDYSGIHIVSICQQVLAKNFSYHPPCQDKNLRECYIKFLTSPMSLRDQEYTNKIQYEYQKGVVKYCLNRLEHEMSMHSVDGPLMNKDQKPPKNARNPAAGAQWQAKCDNFEFLNRPERIKRLIAVLESIIELLQTDLAICHSKYTYNLGTHILKSEKPLMTFILWPGNIRYCGTVNKNCTQIMRIFVYLCHLEYPSYMLDVVANWLNTMVQTFYLCESNATSDYPHIDKFCNHLASEFYKIITKVSVESIDRVLVRIQPPFMKYHIGMIHIKSNFPVRDDCILKILIRFVKQQQWLRYHDTNEPFQLMPGNHVLKHLFVRLINKNLDWIYGDAEEELTTYSKLGEKTLQVVQGGSGGRSSISLQHAVHVLYLTLEAFLESYNLYGVQKLWCIWNSSILDGKELLRRLKEKTNYSLTEDFIKKYDDNLSALQELQNVYYGSVGKENVPEIMRVFAKLLPLYELEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G640</accession>
    <name>A0A835G640_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G640"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="6">
        <location>
            <begin position="265"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Mutator-like transposase" evidence="7">
        <location>
            <begin position="679"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="927"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="142724" checksum="16946A7FD7A4080C" modified="2021-09-29" version="1">MFRVLADGDIENCLEEIPSDDDSCCSAESDQETHDAQPPTMLLGDVVGERLQSYSFDEEDSEPLSSLRSTLPPQEVATPVAEESTSSSLQTRAPKWKKNYSLSPPGEFTEDVGVPAHILELESITPLALFRMFWSNDLQGIISFQTNLYATQSGKAFTPTTPEEIDVFVAVNLVMGIKKLPSYRDYWCSAPDLHDTYSSMFMPLKRFSWLLHYLHLNDNNVMPARNSPGYDKVYKIHPLLDIMRRNFQHNYRPSEKIAIDESMHNYRPSEKIAIDESMVKFKGRSYLKQYMPKKPIKRGYKIWMICAQSGYCLDFELYTGKQGSEVGKDLGGRVVRQFCSSLRGKNHKVYFDNVFNSYQLQIDLRDGQILACGTVNSNRKLLPKLKEDKDLQRGQHDYRISDTNVSILKWRDKRSVFILSNYHDPKNVGKVTRRERNGETVEISCPEAVIDYNSHMNFVDKFDQLKSCYDIDRKSHKWWHRIFFHFLDCSVVNSFLVYKELQSTSRPELETLTLKNFRRSVYQGLLAPAYVNQRRHHSVDSPRSSGAPSSGPAVIKRHKPTVADEIRLESNRHQPERSTSRRCAKCSTSNTPVRTVWKCKTCNVPLCLRKGKSCFEDFHKKEPRDSQSKTAKLLTPLTAVNPNSTDTGTTQEQNYRETTEVPYLVETDSQENLYLPIQGRRIVNMMYFIQQLQKISSHSSLFDCNLKDMTLIGESRNGLISKYKFKCIMCQKDFIVTNEELASEHNINANLAAATGITSAGIGFSQFKEITACMDLPIFTKSTYLKIQDNVYEKWEATAVESMEIAAIRERDAAIVGRRFGQVLFIGKRPEIVDSRHARGMPLREKESPKLDHQVENNPCRKRRLIFDGSPTLLSSSSDDEKENYLCLVPQTMPYICACVSTGARTFHRLSMTERDKRYLPGHARDDDTKATCLYCDVSVSRGSKAVSSKGFTTSNMWTHVKRYHEKELKNDTPSTSTTEAGPPLKKQATLEHVLNKNVMYDTDDPRAKAITQTIAEQICIDMEPFDIVNKQGFNAPLSSCERHSGENIAENLRQLFQDWGIDEQVRAVVTDNAPNMGLAVTQVGMERIRCMAHSLQLVLRDAMSSHAGILPFRHLGDFLNSCSSVAVQASLPHVKCKTELATEEWVLMEQVVSALTYFEEATKSVSQESACLSDAIPLINSLRRVLERIKNTTAMDDNAYSPEYNAFILNLIAGINDRFDYLETDETFILATALDPRYKLRTFTLQSTSVNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G748</accession>
    <name>A0A835G748_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000450">
        <property type="protein sequence ID" value="KAF9407634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G748"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="11719" checksum="E49EF3D13E606A22" modified="2021-09-29" version="1">MFETGSVCNTKPLRRDAMPIIIHKTDVSPPARATLILAELLGLKIETREVNLPSRQQFSPEYLEKNPLHTVPLLEDDGLVLQDSHAIMIYLVSKYGIEHEKSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7U3</accession>
    <name>A0A835G7U3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000242">
        <property type="protein sequence ID" value="KAF9410893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7U3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="285" mass="32610" checksum="B513D9E78E4B588E" modified="2021-09-29" version="1">MDLYGLLESGFDSEASTTSHRDYEKLSVVAKVRLYRNPYTIFFISEDLSILPDEEYYKSIGVKIGDCCELEIDGEDEVKKKLKLRTNALFLQPFVKECVNSDVYRANVVSHLNRLGGYPACGTVFLKLILEPPDIEIIDYAWNERILRLIWTRVEIENAFSWLSTLGGAYSALGDYFDHCAEEAGRISLRQYKLSIMLGDEGLAARSRLYSALSQAQKGNLHISRNIVRRVAQFARETQDHRLIRMCQGIWAKLKYLRSLKHESLTTKDKDCHNKNGKVQNAVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G829</accession>
    <name>A0A835G829_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000324">
        <property type="protein sequence ID" value="KAF9409340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G829"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="12995" checksum="AA8C72A06C8E1D3E" modified="2021-09-29" version="1">MPRRECCVFGCHQFGFISSNQDESIEIQSVPEVLSESMDIDMVPQILPGCSSQVPNPELVTKTGKISKVKQTKQMEIMIKKIDYLKKKLNVQKDQIKAAQKMETSSTSRMYRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8C9</accession>
    <name>A0A835G8C9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000311">
        <property type="protein sequence ID" value="KAF9409540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8C9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="467" mass="52290" checksum="B3CFBAA430ED4DAA" modified="2021-09-29" version="1">MSFITVKMINKEVDGEQTCEPRLAAMLAAHLVSQVLDEAFVIANATAVKGEKGHPWHYQSTLKNFESDKQCDAHDEDTSFEASKGDSDIVNENKIEHAANVVATSTPEKVTDDLQKSKPEPNLIGQGDEELESPQNELTKSTSMFINHLFDMSEVEKVMIFDDTEIVHNNSEPNELLTEAMNKIMESYVDTALGMTIEQPSHSAAGMIMTVEKTSSPEPSEYSFLTDAFAEDIAKDVAFYIHDDGSGDVDRSSARSHLVPNVEIRELCEDDIPERLVESSEVARYENAFLSLNRDYEQNSEDEVDPILEDPKGMTLQEVELMTADTSEENVSTNRDEEPHICPMMKELVSAESKVSAAASASKKSSLVSRCRSQGARLLARIRGWWRRRTPGKRKENLVPFAARGLCPLSPDARRRAASLLDQRLLRSPSPSRNVVWKFNTVNESFVHSSRWKGYTFDVKPDECGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAE4</accession>
    <name>A0A835GAE4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000291">
        <property type="protein sequence ID" value="KAF9409878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAE4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="275" mass="31342" checksum="4879488000E1984E" modified="2021-09-29" version="1" fragment="single">MDFSSCFWDSSEHPPCRCEFVYRWLSDHLIYFQQHLISEPFADTYLDEDDDEFNLMLSQLQRHYNCKTKQLTTVFTVIKMADNHRACSRSFDVCEIQVFVFHTERVLVPDVTVLSRNMVAVVHNVTDVVQSMAVMGHNMNELDHYMIVIIYIARTHIHLRPNMCQGMDPMSGVVENKFGGHSTSGTPGCVHRNAYQQIEPNISGNPLRDMDGHQLAFAQYGRGLLPYEAPPPYSGPAPSFHGPPPPYDGPQLPCYEPPPPYYESTPPVHREADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAK7</accession>
    <name>A0A835GAK7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAK7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF76">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="449"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="579" mass="66281" checksum="E928B25EFDC485F6" modified="2021-09-29" version="1">MNPHTLDFSKSPISPIYTPTKRRILGEIQVPKSPLDRLKSPLTNSPKQVQQFKSPLQAINSPLLNRTSPFLNQMSPVTVKSSPLSTRVKRSRITKVMEERNKFRMANKENDAPMMSETFVKLDVEEETRDFLFGNRFESTREKVTNWSSTKLDFSHTIQKSPKQDSYTVPEKEITQDLDEFQTLHDLEQEFEADNFDQCTKYEIISTDSPDIISRGRTTSSRKVCSRNFVFGAPLADDEASTSFNKPTVSATRMLNFDDEEFDFPSPVIKKQAVKKSLKFTETPTKLRHEKSDSSIGSMSLSQSPLTKTSLYTTESTTSMESGFISELEEPFLEIEDSNSPKVENFSDLLSGQIKSNVIPEKSFLRRPLNRSLSLNPESRARVSLFSILENPNMQRNKKRVERTIVDPDLIGDFSVPYALPLTAGDHSDLKSISCDTLAGLLRGEYDNVISDYQIIDCRYPYEYEGGHIVNAINYYTPSQIMTLVDQPAPEKKEGRSILVFHCEFSLERGPKLSRFLRSSDRAKNKDRYPYLSYPEIYLLYGGYQAFHRAQPELCAPFGYTPMRDPKHAQLLKEHRQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAM6</accession>
    <name>A0A835GAM6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="155" mass="17450" checksum="639E177CE4DD09B1" modified="2021-09-29" version="1">MNIQPCGNVTAVAYYIAKYASKYEPNDCGDVFREAVQKATRHSNDVWKQLFALSMAILGQRLSDAKKKKKLSQRSKGCHQKIKWPALRRDQFEAGELPEAVLNKFDDETVRTRVKDAEGLVAIAPTYATFQANKGYGDVKRLMLPLILSWAATVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB37</accession>
    <name>A0A835GB37_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000244">
        <property type="protein sequence ID" value="KAF9410825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB37"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="709" mass="79841" checksum="C7BB8ECA598EB489" modified="2021-09-29" version="1">MATEEAKPITLKKLPLILNRKIIIRKGIKPLSQNVRVLKSLQNSIKEIVIYKSKDGDFMSGEARTMTIVNRLNMLTKACRTIARCESYIGQTYEKTSDEITKLIGQKNYDFLFTSLCSIINQELKVRSIYSLLTIAKSTNFAACQTEFNDVNFNVNKKTLDAILQTNESCLKSSIRKGRRRQKLAPVVVKDPPNEVKKPRRIVINPDKFSEFQKDNNETVSSPEASSLPELSSVFDEDSNSNNSVGRFSSLSIKTTSDLMDNPLNIISNVDRHTRDIKSESGPFSVTEPSRGLNIESPKSHADGQLGLNLKEMLRHVPPEQRIKLLLRQGLTEWKNCLTMDQEGHFPIHVAVLTNDVDLLRRQCLALKMRESTVDLLADGMTPLRMALYQENPELTSILLDAGADPFDTDDENRSLFHVAADLDAEHLPVLLNHCRINVRKLLFENEDLWKPGFEKKTDEELLPILMMYINRQYDYQGYTPLMLASKSGRYNNVLALVESCRASVNMCAPNSGNTALYLAVSEACMDSVERGDKTKIVDHYKRTIEILVENGADPTIVNFAGSNINELLTEFSIPELSMLIANKLTSVRYFDNALPYGSKGSDFMLFKNDKGEVNIKELNEKKTVHPPVSENVTVKKSVVWTTFNNVFLKVGTKAELAKMEEKFATSNSNAIVEESKTDEPIIATEETGSEKRKCNAVAPLIIKRIKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB67</accession>
    <name>A0A835GB67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000194">
        <property type="protein sequence ID" value="KAF9412277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB67"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="106"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="36848" checksum="2FF326AC0B5D4D61" modified="2021-09-29" version="1" fragment="single">MKCPIPLPCPKCPNEAAQMSYHGYECHILPLIWKSGCSITCHIALRMITQHNKEYFTKVSQELDTKPPAPYKTDDYRNIYHLVSHEDKRSKLDFLHRTQMTAFFVKLLEVSGYFEGKPRNKPVNLDELKTMGVDEKYKDDVALIGGLILKNLQILKFNAHEVFELQCPKPKVGKNVIKHEGKSVFLAGAVFPTLALFNHSCDPGVVRYFCGNNVVVRAVKNIKKGEEVSENYGPIFTTVPKEKRQAELKEQYWFDCNCTPCEHKWPMYEEMTENYMRFKCDSDRPCPNVVAVPYDSQEFMVQCGLCQQYTNILKGLKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBE7</accession>
    <name>A0A835GBE7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_009062</name>
        <name evidence="12" type="ORF">HW555_010271</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000249">
        <property type="protein sequence ID" value="KAF9410726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000356">
        <property type="protein sequence ID" value="KAH9639093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBE7"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9639093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="245" mass="28063" checksum="E5262AD0D85C2196" modified="2021-09-29" version="1">MNLRAEREIGSTAYSKLFQKIDPTDTAYQNYLKVLSKHYFTVKNIIQEILACRDSMESLNKLNEKGRAAISLLRDELENFEMYGKDIGDMKYATEVESQRHQLACLLKEFKEANIMSMFAIEKAERDELLKAGERDDSGIRNRKTKVERDGLLKMSSGVTEQLLSISRQLADTAQRSQDTLDSLVSSSSTVHGTQSELQNTASTISESSKLLKKYGRREFTDKVIMFFAFLFFLAVCLYIVQKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBN8</accession>
    <name>A0A835GBN8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000217">
        <property type="protein sequence ID" value="KAF9411681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBN8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="26954" checksum="A5BD00AC0FEF362A" modified="2021-09-29" version="1">MSEYSDLVKIHESVQESVTRRMNEVEAQIQSAGQAKDTVAKVAEEFRSFRELIFKILGLLRSQINECSRRIDDMETRHRRKALVFQGLVEAEKEDCRKLICNVIKSKMSLDISESLITVCHRLGVGQKDHHRPILVRFNSLDLKASVWRAKAGLRGSTYSVKEFLTRTRQTVFTKARQHFGMRSCWTQDGVIHVKTGDGSRHKVTSMEALDSLLLKFPRAPGNKTDDRPTVGNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBX0</accession>
    <name>A0A835GBX0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000237">
        <property type="protein sequence ID" value="KAF9411047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBX0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1241" mass="141752" checksum="20374D2C164D6395" modified="2021-09-29" version="1">MAPGATTPKRKKSRGSRSLCSPALSTASGRLTSLIDQFKDKNMESFALSPLNRRSILNDDTAIEEPRRKSWWKNLKEDSQQIMEVLEENKVTDANNGIEELIDIEVLSQEKKEYTLDLPESSDNESINSIVLPQRKLFTQKDSKPQKKFGQFSDNRETLAKLHKTNTNVDKTVNVGTRELFQNAKRSKPIFPSALLNISPNKTTADKTKENILPEPKVRNIFGNRPTNKRKNMFADFVVSESEDEIPEIQPRVFGFQKKLEQRRISSISKGREGSPASSITTDMEMDDWKLLPSSTMVENQLEDIVAGHTPKRARLSKLSEAGTNTEAGINTLQTNTTGDKTKASNKSVTSKNKSKSSPDVKDKSLNSSRTTRSMMKNTSKLEEKIDASKQNTKINQSQDKISSKDNELDDKSSKVENKQNTSLNKSQRLNKSRTRNSSKIIEEEKEGDENADNDKNPINNVTRVINKNGSNATLAIKSINEKERTITLKVHDKAKTDANKSKSNKSIHNEPKQAKIVEESVESTNEQSANDNVDGNEILNTEIDENYEHQDADTVSHELNEQQNNSEGEKKLTENIEDEENEEEMNVSQGNDNETNENDNTDEVVLSKVDEENESEINEENVDVNQSNENEEPNESKVEAEVDGSQEIDEQNESQENENEANESQEIENEANESQEMNEEVDDSKIEENTLEDENNESEEESQEVQNDEEEDDVDESQEVDDAEDNDESQELENQEVSQGEHEVSQEEHEVSQEVEQDVENDEESQEMENDEEENEQSQEIEDDEEEENEESQEVDNEEDNQVESEAEVNESEEIEDDKAMDNSDEADKAIASDPEISDRDDNDAEEMEFDDDDNNEQESENEEAEGNEEESHEEQQEPSAEEIEESPNSPEAILHDKTNQMDSFTAKGRNTSIRKTKSMIKNLNIRPSLAPQRDSLAFSDGTRDSSAEGSGWDSHRTTRKTLRQTFGKDFTPRKSLRALVMEKSAKRQTEHQDLHSDTVKYPQANSTELPEYSNGHVEDFVESDHEVSRRTRQTTLETYLQKIKQQNIENKVKMEQLVRNSLKAPSRDTLSLFKVPNKPAPRRLKLSQNKPRTQIKSIMAFGELPTEVIEDMKYKPPKRFQPTNASWITKRLYKFLETKLEPKYDYKARVRAEKLVETIYHFAKDLRRHNVAPTDAVDVLKHELARLEVVQTHFDFYEFFHEFMPREIRVKVVPDIVNKIPLPRHGVFSDILRGNNVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDZ0</accession>
    <name>A0A835GDZ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008655</name>
        <name evidence="3" type="ORF">HW555_008981</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="255" mass="29454" checksum="38E87CD704E841BA" modified="2021-09-29" version="1">MSQHRNLSVVERSSIINLRDSGLNISEISRELNMSRNTVKLWLRRFDSEGSLERMPRMPQPSILTQERVQRMVSVYEQHPFTPTRLFAEEFDCTAQTIRNGLRRAGIRNRKPAKKILLTEAHKTARVRFARDYRDFDFSRVIFTDEKSFKSSQIGRRHLWRVNNTRYEPRNVLPNNESGRVVVNMWAWMSAAGPGELVYIPGRATGATYLELLQDTMLPTVWESLRGSDLCESLVKSMRSRCDAVIDAGGALTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEJ6</accession>
    <name>A0A835GEJ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEJ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="358" mass="40463" checksum="3064918168AE6B27" modified="2021-09-29" version="1">MNCDCCSENIAEGSAAVKCSSCLKPYHHSCLTQLGCDPQLAEMHNWVCPSCKPKKRNADSTPVRNSQASDPNVTLRKKEPSIDELMRHLNQTLANYVNTQMKAITDKLEGVNSSIEFMNVKFEEMKTEFSLNTKLVNELKKENEQLKTTVKDLGMRLTQMEQQARSTNVEIQCLPEHNNENLVSTVLNISKVISGDINESNIHHVTRIAKQSPANNRPKSIVVQFSSPRVRDNFLAASINFNKNKPSEEKLNTALLGIAVSAPTDVLSKLDVHHPPILCELSFTHFKNPRYCNNRTKLNYHRADYVAIGEALEQVDWPSEFDPCMTVDQMVDIFYNLLCMVLLEMVSMRPHMLTRIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GET0</accession>
    <name>A0A835GET0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 164</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_016530</name>
        <name evidence="2" type="ORF">HW555_007213</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000582">
        <property type="protein sequence ID" value="KAH9634969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GET0"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9634969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32858" checksum="460285398E79E686" modified="2021-09-29" version="1">MFEWAYSGANKAVPRNVGPECAYYLSTKRQIIETIVVVSICVYIAIKTYPKLTIPQDTNYIKSDRGGKRLLVILLALLWGMEIGFKFASRTVIYLLNPCHVTTLIQIYLLAAPPSKTVTALFRIHLNLLNGPLLAFLFPETASRKIFAEAALYWIQHGMMFVIPYYLLRIGGPYNIEPFWDFNWSIFSYCLNMIYHFIILQLIAIPAQVNLNHMLCPAILDPFDGPWYRVAAVTHQALLCPLLCKMFCLISDFCLTKFPPTKVKPHMKDSLMDSHAVAVTNPVEHHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEU1</accession>
    <name>A0A835GEU1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="280" mass="31916" checksum="E6EE6959C1660CC5" modified="2021-09-29" version="1">MVHPGKSRSTHHTVRFTGDEMPKYKPIVSDSTDSPNYVSSQSYPGQDSGAPSPEAFSFQPAAQRYRHNEQRIKLLTSINQIVQQRADLESNRVTLSNLLDELRRKLKRRIDECHLEKKERMKALKQANQRLEKEKFNIVSEIEHLKRHLEKEEAHHLQHARTAVAQAIQGVVTKCAVSDSMFSQCSVADLPNVVSRSVAKNAPSRNADNKLAAARLMRDIAELRQRVAQVEARLANELKRKRQAELDIIRLRKELSSTKSFVASLRMPPPPLRKQCSKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFY5</accession>
    <name>A0A835GFY5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_001532</name>
        <name evidence="1" type="ORF">HW555_007601</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000853">
        <property type="protein sequence ID" value="KAH9629719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFY5"/>
    <dbReference type="OrthoDB" id="7464868at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9629719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27103" checksum="9906742A69E0B063" modified="2021-09-29" version="1">MSDRVIASRPSLEQVQAIVDFMEKHPALGLGQLRGFEGRDEGKKLWLKLTRLVNSLSGPTRPVKSWVKFWADKKSTVRSKVQATGDPNNLGSNIEKKIWDLFLANETGRPRGAVKREVENNFLDENFYNEDSIEHNNVESEQVMTFEDPITDTEERQHQLMEKMLKVLADQASAMSQLANASHLNAQAMERLAEASQIQARAIDRLANSFETISAATHDVRNAIVDIDVTMKRFYSTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG57</accession>
    <name>A0A835GG57_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Testis-expressed sequence 9 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG57"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41402" checksum="4A002A7FDCE05850" modified="2021-09-29" version="1">MDSLDLLAREDEFKKLNKQLEKKTESLMKEIEQAMQKQDIFSEFSPNLTLSPVHTIKKHSCESHKPNTESPLPPPKPAQKKKKPQTTPEHESGKIENGKQSPDVGSIVNSEEVVPKSFNTCNCCANFNVGRIGDNDEFLYAFVSVNVKEKVLPQSFLKDRPTVENVCKFLSSKVKLMQEQIDRLQSTLDKKASQCDGHLRQLAEYESERLSLQCKMNSMSAATADMKGKNLVLLAKLNDKERQYKEQRTETDKLACELKRYRFKCASAEAKSASQQETIDNLKQQLETAKRSEKDFRESSRNLSTSHQNAISRLEAHIKILNTRSDRQMALIDNLRKQNALLATEGALKALEREYCDYLNQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGJ9</accession>
    <name>A0A835GGJ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGJ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="175" mass="19760" checksum="4767C065EF2DA5B2" modified="2021-09-29" version="1">MKERCNAAIERMKEDFAKNLSLRSTTGSMESLMVKFEGKDYELQELAQIVRKNPKTIVINFSSFPQAIPNALKALQGSGLNLNPQQDGTTLYVPVPKVTKEHREALAKNAKALYIKCRDSVKDVQADFIKKVKKQSSISEDLAFNVSKQINAICEEYQNEAKHIYDVKHNELVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGW9</accession>
    <name>A0A835GGW9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043195">
        <property type="entry name" value="TTC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28956" checksum="B75CB2D7CC20402D" modified="2021-09-29" version="1">MSILNNPAIRDKRSIELDEEFNNFMKKVGEVSNIVKDMSSGDKAKAEAAKALADQYLDGKVILDEDVTLKVKQNRTVINEKAFHNLGIQMRADRNIHNEVDKESWMAEVSKDAERRYAERKVRRERADTLKTQAIKAFRREEYDRALSCYNRAIEQVRDDPMLYCDRALTKIKLGKFDKVFDDCDLALRLNENSFRARLYQAKAYKELEESAKLEECRKQLDTMFPQHAELIHDYLDKKEGYGDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH95</accession>
    <name>A0A835GH95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19611" checksum="379CFBC7CB186BEA" modified="2021-09-29" version="1">MDHGNNCDHSNCSHANASVTQTLSEMHWERGLWYAAFYGDEERVRSLIAKADNAKVIVNTPDNSGYTPLHYAARKGHVHICKILLQNGALIDAKTKSGQATPLLKAAAAGKIETIKFLIQSGACVDEQDADGQTILHKAVENKHFDLVNFLMETYPKLNTMQDVKGNHPSDYMSGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHB2</accession>
    <name>A0A835GHB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_006893</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHB2"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002995">
        <property type="entry name" value="PRK03759.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="83"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9415471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="258" mass="29504" checksum="EC2DB8D5117779BB" modified="2021-09-29" version="1">MLVRSVVTSYKCGRMLWNTARVDKKFVCINAAMNQSTEARDITDVQAASLKNDMCLLVDERDNIIGTATKRECHRVGPNGMVPLHRAFSVLMFNSAGELLVQKRASQKVTYPNAITNTCCSHPLLIDGVPEDVTTAAIRRLNEELGIPKHQLNREDFTLISRFIYADPGDGEWGEYELDHVLILRSDAQVKPNPNEIDDVKYVARSKMDSFIENQKDPITPWFKLIHQHMLPYWWDNLHRLKDIAEPDTIHSFVNKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHF2</accession>
    <name>A0A835GHF2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_006023</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Conjugated with ATG12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a conjugate with ATG12. Part of the minor complex composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa); this complex interacts with ATG3 leading to disruption of ATG7 interaction and promotion of ATG8-like proteins lipidation. Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2. The ATG12-ATG5 conjugate interacts with RAB33A; this interaction is bridged by ATG16L1 and promotes ATG12-ATG5-ATG16L1 complex recruitment to phagophores. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate. Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection. Interacts with ATG3. Interacts with ATG7 and ATG10. Interacts with FADD. Interacts with Bassoon/BSN; this interaction is important for the regulation of presynaptic autophagy. Interacts with ATG16L2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Preautophagosomal structure membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHF2"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.620:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000100">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 15" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="18">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="17">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="16">
        <location>
            <begin position="187"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9416710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="31190" checksum="68F5CA7FB7A84696" modified="2021-09-29" version="1">MANDREVLREIWDGKLPICFQLAQEEIMEIQQPDAFYVMVPRLSYFPLVTDKMKRHFLRYISQENSDSEMWLDYNGQPLKWHYPIGFLYDLYCGNDPQLPWHLTVHFTKFPEDILLHCTNKDVVEAHFMSTVKEADVLKHRGQVMSTMQKKDHNQLWLGLQNDKFDQFWAINRRLMESHGDSEGFKHIPIKLYSDDGTCSQRLVSPKNNDGSRKTLQQMIAELYPDKLDVQLRTHGIVIPSDTPLQWLSEHLSYPDNFLHMCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHY5</accession>
    <name>A0A835GHY5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHY5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="35554" checksum="CB330860A526633C" modified="2021-09-29" version="1">MEDQRTDYGLRVAFFYIAGVATYSTRQSHQCFPNYGGIEPLGQFERHVQCRRCSGLGLGRQEEIDWRDVITEAEQIVGYPTSFLNLRWLFNDEIASTAIHLRKLVGSNHPVLKSAKNLLVGSKSNLQSVGLIILLVSKAAGFDTTKFLRDQYDSGVLHSQRALAEIVEMKRTGHMIHKAMVNLQKKGDQGDKYKDLLYGNKIVLLTGDFLLATCLQHLGGLRNNEVTELISTGLRDLVEGDAFGNHDNDGNPIPTLPKAKDEEAYYDWENEDNLQPLGSNDFLGRGIAEWKLRTMLMSGSILRQGMPRSNEACQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI38</accession>
    <name>A0A835GI38_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_004519</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI38"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9418691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="429" mass="48354" checksum="DB77DAA80856839E" modified="2021-09-29" version="1" fragment="single">RKKVLLQFDAVIGQQAAVYLESVKHLIELGLSGRVVSASRPMPRLRLLRQPHHLLAVVHDRDHVMWEIIILSILSVIAFLITDELIPNLTDLFVKAGLFGIDLCKTSKKKIPEAIGVVSGCVFLITSFLFIPVVFGNGLMDTQHFPHNEFAEVLAGLLSICCMLLLGFADDVLDLRWRYKLLLPTVASLPLLVVYYVNFNSTTFVVPIPLRQWLGVSINIGVLYYVYMGMLAVFCTNAINILAGVNGLEVGQSVVIALSIILFDIIELRGDQYKAHTFSLHIMIPYLATTLALLKHNWYPSKVFVGDTFCYVSGMTFAVVAILSHFMPQLFHIIPCPRHRLPKYSEETDLLHASRTIIVKKEMTALTKLILRVLTLLHLIDKIEDKESITINNMTLINLFLIKLGPTPEVQLTKNLMMFQVFSFKVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIU3</accession>
    <name>A0A835GIU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_011329</name>
        <name evidence="6" type="ORF">HW555_006343</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000878">
        <property type="protein sequence ID" value="KAH9629066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIU3"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9629066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="13723" checksum="6B18FC4966A04B88" modified="2021-09-29" version="1">MGKIFLDHIGGTRLFSCASCDVNLTNRSELISTRFTGATGRAFLFHKVVNLVYSEVQDRVMLTGRHMVRDVSCKNCGTKLGWVYEFATEENQRYKEGRVILERALVTESDGIEEIQVNNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ48</accession>
    <name>A0A835GJ48_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ48"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF119">
        <property type="entry name" value="FI03731P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9419478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="35082" checksum="319DF8208884AD6A" modified="2021-09-29" version="1">MSLKRVLIVNKSFPVAGLELLKNKVETIVLPHLDYEAESLPSIKDNLKGIDALIWNTKHKLTGELLTLAGPQLKAVSTMASGIDHIEVAEIKKRGIPLGNTPQVLDDAVADITVGLMIAAARRFKEGVQELEAGEWKYGVQWMVGQDITGSTVGIVGFGGIGQAVLRRLRGFDVAKFLYSGRTDKPEAKTLGAERVPLEQLLRESDYVILACPLTKETKHLINANSLKTMKKTSVVVNIGRGELIDQEALYDALKENQIFAAGLDVTTPEPLRNDHPLVSLPNCYIIPHMGSATVDTRNKMASISAQNVLLALEGKPMLFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJP0</accession>
    <name>A0A835GJP0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="28189" checksum="799F8B732A529ED7" modified="2021-09-29" version="1">MLVPPFEVRAADPYMTNLPTQYQPNFQANVPQPHGFNNIINHKRHSQISTTENRSNQNMTFGEFMRVLNEESRQSQGSVQELKGLRPPATAGREDSPAYPTLPRPVGYRPDYTPPPNYHESASLVPHIQPSSAQPKTSLLNLSSVLSPAGSNGGGSGNLSGLLNLVFSLFGGSSGWNMNGLQGGIVEGIIKPLMKAKGGIKALISKLSIPMISLMLINLEVLVTIWWLWEECPSPMPEPSPNYSKASTHSYNYNSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJQ2</accession>
    <name>A0A835GJQ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJQ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF44">
        <property type="entry name" value="ODORANT RECEPTOR 13A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9419273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46587" checksum="B4BF9240B1729413" modified="2021-09-29" version="1" fragment="single">ERNVARKEIHETLNLCNFCVRNIGLSFIDIPKSFFQSLTSYLSFIMSSSLLVLMLAGEIAYVAAQMINTASVEEFVGSYLHIAGYDTMSFGKLITIWYKRHTFRQLVVELAEIWPVSFKDRDGVEIKRNSLSTLKHRQLLYAFWNILGVWLYNLTPIVVLVYRKLRGMPAALGYVWQMAYPFDKTKPAVHGIVYIFETCAGCISVCCMLGSDLLFMTMASHISMLLRLLQNQIRCIGTVGSKDSSDMICYKDIVEVVKIHQRLIRYIKDLEDAFSVVNLINVLLSSVNICCVMFTIVFLDSWMEMSNKFYLGAALTQIFIVCWYADDIYRASVGVADAVYESGWYKSNTRCRRAMLVILQRSQRPLYFTALKFRAITMITYSSIVEILTTAYSYFTLLYTSYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK09</accession>
    <name>A0A835GK09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002395">
        <property type="entry name" value="Kininogen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00334">
        <property type="entry name" value="KININOGEN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31682" checksum="C1AEE45C486104C1" modified="2021-09-29" version="1">MRNVGMVFYRLKCESSRSLKVMCLKSEGCELARGGGRLARAMATVSRSRARGTSPRSHTSRTSCSSDMSGHFATTLCRSSDNISTSWHRTAVISAREIREKRDADLEAAASHGHHWDKGGGHEHHGHHHHDHGGKHHKGHKGHHEHHHGKHGHSHHEGHKGHHGEHGGHKKHHHHDEGYHDHHHHGEKGEHGHGHDEHGHWHKGHDTKGHHGIEKHDEFKKDKHFHDHHGEKGFHEHHGGHHHEGGYKKGGHFHKGHKHGGHHEHHHVAVAIRRPWSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK48</accession>
    <name>A0A835GK48_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK48"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="15849" checksum="B0E0AADA7BB19FEF" modified="2021-09-29" version="1">MADTLKTLLRKRSALKSKLTIYSNFINLVKSSAHISEMQRLDLQERFNKFDSLHSQFDELQTEIELLADDAETAFVEREEFDRQFFNLVALTRSLLGSSVNGAGSEAGFKDADSERSEGSAAAGSPAGAPPAPASAALPSVAIAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKD0</accession>
    <name>A0A835GKD0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Extra sex combs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKD0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24618" checksum="E26BA9DD879B6632" modified="2021-09-29" version="1">MNFSDNEADDTSSVESTSNTDNTSRSETPTNSRVKKRRRGKKKTTKQVKPPYKFNCSAKEDHGQPLFGCQFNHHLGEGQPQVFAVVGSNRVSIYECPDSGGFKFLQCYADPDVDETFYTCAWSYEEETNLPLLAVAGSRGIVRIFQPSTQTCIKHYIGHGHAINEVKFHPRDPNLLLSASKDHALRLWNIMTDVCIAIFGGVEGHRDEVLSADFDLKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKE1</accession>
    <name>A0A835GKE1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKE1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000291">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF569">
        <property type="entry name" value="IP01065P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="34540" checksum="B06B08F902AAC898" modified="2021-09-29" version="1">MAGPYLSPLPGDLLTEYMFGRRRQRRNRTTFTPQQLSELESLFQKTHYPDVFLREEVALRISLSEARVQVWFQNRRAKWRKQARLQLLQDAWRMRCLGLGSPPLPLSGHGKPDSSPEASESPNDKDSPEPPGANENRELKSPRQDPYLHNTNMEQIQTVNSNVHELPPMAYNEEGRMLQQPFTFPPMMIPQQMEPEIVPTDLRVMSKPNPCPCGTVQDMDEPQNLAYRQQRQDKESDSDSDTEIDLTSHSKDDDIRESERLANRIATSIFRSDTVLHEMMPNDLSLANKNNDKVRSNVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKQ4</accession>
    <name>A0A835GKQ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKQ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123738" checksum="50612E3AC59EB8B8" modified="2021-09-29" version="1">MELCRYMGIKCTIEIDDRIVLILQNQQLRQEKMEMVDDLEGCKVVCEAKMQGRLDELAKKKEMLNEVKEKVLECRCKLPVDKTVEVKRTPSLAAICRCAPEDKLLESCSCTSLRSRLLSNLLADLFGGLQTELGGSGSQMPCQLLKCLDDKHNWDRASAIKTNLRNFFSKLLMGELNIAIASSIENYHAKWAGASCADIAKPIPGSDDDVREGWEQRALEKRAQKMASQLAEQLFQERAEQLAQRAKEIVTSGPPPCECKPHIKKEGKTFLAAAFPCLMPPNSLFSPGMFVVNRQTGDTTPVFWKRTIQDVTQLKLQIEDLKKDAIKKEDLKQMEEKIFKIVKEASVIENEDSSVISTLPEDSFKKEPRIVKNGHTRDDSPKSINANKIKKKNYDTNNVKKSPIYEKPTKQSKKQPHGQSYAVNLCLCGVQKNSKQLQNSYVNNDGKSQSWKQPQSSVTKQIKPININTPELNENSRDTSGFCDKKCKCFHNIPSTTSIDKLLDTLAKWKCNLVETQDMKNFKSSLSKYSKSAIKESLRDSKHDDSKNNLSVSKACNKDKATEINIHKEPHVKTPKKLHQTHFRESILNSESEYMGTVNLDKSNENCKCIHNIGRVLDDNKEKVKTTANSAGFKFINTTACECKIYQEMQKDHKRSQTDEVFKEQLQTNQRQLVQTKDIPELIKNNASKTCTRVNSSNDMKQKSNMNYLPTKAELFPNNCDYCIKFLGVTLDDLTDKKINNIIKDNPDGILSPKNKFLEQRQKLSKKSSSFEPNLRGDCEVNYQTGCNDDAKSNFQSNYEKFEEFKGLLADFLNHKAPEARYKDEALDSQSFKSIAKNMESCVCCNNIYNLDDSKDLEVNAFHLLEDHLKGKLEEFKSFTCKSSCIPPEEEQKLFSAILQRVKQDILVSPKEFPEKDTNIDQIMHDKEIQNYCVVPKLSKQNSNKSMIPTENTSFQVLPYFGMETKSCDVMGIEANTFEENMSLGTVYSFNENVLEWYEYPGHMTPDRSNAAKLANSIYFPGHPIDSYNAPLNANDSLEPPDTCDCDKVPICHVKMLVENIEKNLIESKCTCDSLISKACPVHSKNVIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKQ6</accession>
    <name>A0A835GKQ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKQ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31818" checksum="BE4CF4228184CBED" modified="2021-09-29" version="1">MAGEKDKPKVPKPRQIPKYMNFIIGGTSGMMAISLVQPADLLKTRMQLLGPAGKNMTFIQVARDIVKKEGVLGFYVGLSAALLRQATYGTGRLGCFNAMFDWHKANRGVPNFPTKIVMGMIAGAFGAWIGTPAEVALIRMTADGRLPPEKKRNYKNDNARRRHINIMEGAGATVSRAMVVNGAQLGSYSQAREMLLPFMYDGLPLHAASAMIAGFITTVASLPVDIVKTRVQNAADKSTGQLQVLRSVIKNEGFMTLWSGLMPTYAKIGPMTILIFVFLEQLNKLYFKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLW8</accession>
    <name>A0A835GLW8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLW8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="697" mass="79372" checksum="041783C081E9033E" modified="2021-09-29" version="1">MESEKDRISDPGDGEDIPSDFFDDFNRDDFMEGLSVIDSWDEEDGAGKRREPRRINVEALDSVKDLRELIGDNKEEQGNTDKPFQPFVKFDDRFKWRKRESPEQESSSSSRMNDFIKPGSRRDPSKTNEAIKKDKEVKVKEYLAKHLESTDDIRPPGTELDDYFEGGKTKEIKKTPKRVLEEGPDEQHRPVQYRGSPHYHSPRRQGPHHRASPRRYSPRKRYSPTWSPRPHYHPHPSHLHQYRPRFSPHKFYRKRNSPPRRSPQRRSPPRRSPPRRSPPRRSPHRRYSPHRSHERSPRRRRLSRSPQRRSYDSKRARSRSRSPHQKDTFLYPNEPGMSAYPVEPYSNKPAQLYTAPVQSEFPGSVPGYTYPQGVAYGGGFPAPYNYNLAPGAPSGMPEPVPVPTINPIPDPLNVAPAPAMVPAPALPVIEQKTPYDALAQLVAEGKISQEDYFKLAPNKGATSMMDSKTLSGVMSRCNQALVKLEKLLLPNHLMMNNHIVGSEPKALESKFCSPLKRQASIEFNFTKTNGSVLAQQNQQLVESIITTIGLDKVVSRYKKKLPKDVKDAAVQTTKPFCDVCEIRESTSFQEASTSTEPEYFSSSVHTQVVEQDLVSSKSVFNPTGSISDGAPISIAHLTPAQLVSQLAARAKTLQQPSPVPQPMHPNQYGRRNPNYDYDGRGGGSQQQYHHNYNNYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM41</accession>
    <name>A0A835GM41_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM41"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="8817" checksum="BECAE3D18A0A0E18" modified="2021-09-29" version="1">MLSRGSSSLSSSCIATGVSSSAARLDIPSSKGLRPSTNVLRLNRWTLISFTDVRVVVAVPSSRSGWESASYNRIVRLSCNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMH6</accession>
    <name>A0A835GMH6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032933518" evidence="3">
        <location>
            <begin position="17"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="845" mass="95979" checksum="8BA1501D2043797D" modified="2021-09-29" version="1">MKTLVVVSALVSLAIAAPTLPEDGTEGRDTTLNLAHQAKSTLLENLTKERTPTETAPVTLLHNGAPTTDFLNTQISNDGTSMPMARSFLLKKPLIVKKKYGYKLYRDSEEEKAQADSNETCGRQVKVKLCDENEKYRASMVSTDGNVDIHSSDDDVKHSIKMAKEAVENLQRDLKKMEMKTEMKTAHDSQSDVELHEDIEVARKALEHIHDNFENLETMSLRATATRNSEDMHDVHLTIAKTEEERMAQWKEALENIQKNVEIARNIEDSFKTANTQEDMVHLDQSNAASTFNNRMDETALLSETDQLRLAHGVNLEVHNQERTTKDEKPLEKTMHENMDELIARKTVNVDDDMNFAPSEMIEVHLDNNKHHETLKSESHKIAENAKSAESELEDSKTVVEKNDLKNLQQFEDHNVQEKSAKLNMETLESIPTDASTKPLTFVPVSEQQRTVELNENGTEIQNQQEKVKETDSDDISDFILRSAFNTEESKLTKEDIGNEHMVAKDTEGLNPEQKEFLTETWDLKAKEALPTPHNEIKHFDTMPKSTETLENKHFLMRDNEHAEREKFIQDQLRQQWMQREELNQMETLQAMRTANDNRLQNQKTIFWPQAQSHKNFEHLPSMKAAEDFDQQFETTHGEQEQGFVPENAMDHFRSSYVPEHIHMPSKMGSHVSDLSHSHHHSHFPSRYHQNSMTHQHMHEMAGMGSAMHPHFLPHMRDAMDGFESEHTFHWQPTHESARTAYGASGLSSSVSPSGAVGVFPNANVGGCGIPLLLSCSPSVVSGSLAKAHSAGPSSYSSPQYRMEEDFNFLTKRGINMNDMRTTNTMRAMTTALKQNTPKTLENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMZ0</accession>
    <name>A0A835GMZ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46289" checksum="BBCF9402F5C86A4C" modified="2021-09-29" version="1">MAAAFQQQIFALDARFNAYRAPNNPNFKTLYIRRRSQLLRENAKFKDIETIKKYINVRSQLLQRRYGVQDNISISSSSSRPRSSSKASILVEESPSNSNSKRKNDMTISENYAFSGVHHIFDQHTEQVSVVKFANNDRSKLCCGSDDGTVSICDVTATPPRVSFILDGHTKPVTGCDWSASNELLVTCALDGALSLWEVSGRRRLRAVPDQLGAPLLCCAGNARGMVEVLNISTGIYPRGGSSILGGRVLSIACESSGRMFWAANDKGVIVSYRMDSAGGGLSKLRRCIVGGAVTCLSWSPWLARHPALLVSAADNSLYLFRIIDREGNLQLKKRFEVLHTQHSVKSTFCPIMSFRRGVCVVSGSEDSCVYFLDIEGHAEHPVVNKLQGHASPVIGVSFSYDESLLATSDVTGLVIIWRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN71</accession>
    <name>A0A835GN71_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN71"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="147"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="536" mass="59537" checksum="84A07BBBA4F4D4BF" modified="2021-09-29" version="1">MSETMSTRSKTMTETIDSESTDSPMVSDRWTNNISYRQLVVSACIGIFQVWWHPYLHDFRRLLPFIFLYNVFSVLIGYPLFYLELALGVATKKSVLNCWDIAPMSRGIGFAMLSTCVFSALATGGVGAWCLALTVHSVHTFLPWLHCAAEAQPPCAARHRPLQAGSETPPQSFFYNFVLDLKRDGLAGGLGNVVWELVIYYVICWILIYFIVIKRIYSFSKLVMFKDVLTYFVLVCVGVGAVQLKGASRMFNDCDWSVLFENLQIWREAIEYSLIEMTVCQGSLIMLGSYCPKTQHKLGTTAMLAFAISKSGCMTAALVLGATHGALYKDYENATNILPGSSSSIILWSDYVARVPGSQFWSALVFFTMFVLALTTTALLVQTIMSAFTGHSIRKITGPFLIVVCLLFCLIGTMTLCTQGGLYVVNFLMNWPASKPRVPIAALIATVVTFVYGQTTFCEDVYFAVGEYPSVFMRVCWALSPAIMMLVFAGGAGPWGSSEAMAGWLLLGVVMLPIVIFVLIYGMFKCRVRNIVRDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNB7</accession>
    <name>A0A835GNB7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNB7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="552" mass="64136" checksum="E6350D37A28BE36E" modified="2021-09-29" version="1" fragment="single">RWYRMECACNMVKMSFVNTSNPIWKYFVKLPYVRIAQCKICKCDYSFKSSITNLKVHLQKKHETEYQSYVEIVEKKKQAESVCLTSELWTSTNNDTFMCISGHFINKDFQFKSTLLKCLHLSRTYTSVDLAIIFRFICLDWGIFNKVNMCVTDNNRDIIEAVNSLGWDHCTCISQKLNNILQSFTKTYETTLKKINTIAYRSQMCNKAEKGLDSSQNRVGNSNQPLELLNSIPPMWDSIYLMIEKSLNLKNEIKAIDEKITELPNITDDEWTSLHQLHLMLKPFHEAITELSSEKYIYASKGIAIINGLKDVMKEIEKKPQYYSRLENIFKQLRAKLYEDFSSTEYESKMAICTILDPRYKTAMFIDEVVGETVENAKSDLISAVQQMMKCESQNEINSGHGDQNAMDVDDGEINLWRRRKLSIQNKKKSSDFNQLMLAQQEVAAYLQGDLAESSCDPCEWWQTNQQKFPHLAKIFKTKCNIVANSIPSDLIFTKNGVALRDRRARLPLEETIKFVFLNANLSETDYENYMPRVKEEIFYERNSTDPSNNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNW0</accession>
    <name>A0A835GNW0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_016018</name>
        <name evidence="1" type="ORF">HW555_002988</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000295">
        <property type="protein sequence ID" value="KAH9640087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNW0"/>
    <dbReference type="OrthoDB" id="10013535at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022179">
        <property type="entry name" value="CFAP276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12494">
        <property type="entry name" value="DUF3695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9640087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="163" mass="18591" checksum="964783DA660B822E" modified="2021-09-29" version="1">MAGIKQVRNKTLVPDLRKEGELSKDILLSTQNKHIGTTGSRLFSHHTLASVRRLSFYHPFFLPKDSLDFVLATTYNHSTERFPDKEDLYLQPETIGCDTWRRLRNTFDKCPPVIIPLGHPMKRGGIKERRSQFSVKLMNSGVHSSQTNPGYSRQPAGGAIFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPI1</accession>
    <name>A0A835GPI1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPI1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="347" mass="39365" checksum="BA8685C0286B920E" modified="2021-09-29" version="1">MADISIIIPVLNGEEWIDNCMSSIAEQTVLKTADLKIEIAVYNDGSSDKTRELLQKWEGRFKAQGVGFVTSSGKISKGVGAAKNGAIKISTGKYLCFQDIDDIMLSERIELQWKAATSRPNSIIGSKIYRVPEGSTPRYVQWANNLNSQQLRKQIYTSNGPTLLMPTWFCHRNVYEKVGGFVETGYGTPEDLIFFYAHLDAGGDLYRVEKELVVYAYHERAATFSVKRENIRNIQLERLQKCILPHWTYFTVWNAGKAGRRLVRSLNSENLNKVVAFCDVDKNKIGQCVELYCPTERKVLIKLPVIHFTDARPPLVICFKLDMTNGVFERNLQSLNLIEGIDYVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPR4</accession>
    <name>A0A835GPR4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032978424" evidence="1">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="205" mass="23252" checksum="2B289394284B93C5" modified="2021-09-29" version="1">MDLLLIVLLVSVTDAKMFCKKPKAPLELGEWEYHLKHMDSAVVENPPLSINEGQMYVYENYFPNYTIKYIYVDNLAMRSCGASATIKTGGIDSSYVVLVLHAHINQEIRSVIDIWGERTTVGKSTITEIQPDETTSKKIFHLFKHLRAVNHNSWDGPISSVGCGCMDVPRADSVQEQDRHDISRRHIYIPKRGLNLSLTRPRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPY4</accession>
    <name>A0A835GPY4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_016867</name>
        <name evidence="4" type="ORF">HW555_001083</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000942">
        <property type="protein sequence ID" value="KAH9627713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPY4"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9627713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="20946" checksum="0F10D3BE0649952B" modified="2021-09-29" version="1">MEGDKSDNPKSYSGIPEAVFVDNVDEFMNKPENAGGVDKVLKSLDEQHAKYKHMEMSLATKRRRLRQQIPDLARSLEMIEKLKTQKEEMQTEFLLSDQVFVKANVPPTEKVYLWLGANVMLEYTLEDAENLLSSNMATAKKNLACVEHDLDFLRDQWTTTEVNMARVYNWDVKRRQAAKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQX7</accession>
    <name>A0A835GQX7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="607" mass="68952" checksum="58A0FEAF8C03BA41" modified="2021-09-29" version="1">MLKMFQYEYEKRPSSSVSCETATTVATDWSRKYPSVPERMPNARRPLPPRPTVIHRVPDKTIVPLKVWIIASASCFAVCAALVLATVVITKWDTSETFTTREVFQSPEPIHIKQHQSTMYKDQTTEDTAVMETLSIFKNVIPNREQKSLIAKTQIHPIHEDILHEDRPIKKKDKAEIAIIDIAEPNDVDDKNAVIQGDNNEIVDKFEVNDTKMNVAEDFVPSFKPLLAGFGKSIDMELPYGYLDGRDDYFYNDENLYDDYMQSNSMTNYLIEKIQELHDWVSTDPDFNANQTRKDSNDFGSLLKALNESLVEGNVTIVMHKLRNMYFGENYTHFNASRKVIVANSTDLLSFGILTLDVMLLHNIQLMAWENQELARTKMLQDPDVFAFNALFLDPSKVEMKQNEIAHDSSLFLKRLNPRQDPIEDLDIGKNLLENIMEVGMSTARAAIHLGRAYKNTKNILNQITNKEQQAANIQNQMSRNIDGNTHALNHLQTSFDSTQGVASNGSFYTELDCVWLLYCRNLAATTKLNAPYGTMARINGVALRMLTGELAANKALDTLLYEVLTGWTELKCNEMFPRCSKVNAASVVLDTIMQSHRKSQVSNRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR76</accession>
    <name>A0A835GR76_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="554"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="78989" checksum="50FC297F5E577549" modified="2021-09-29" version="1">MQLSFVDLATLTMHRRQEMEARTQIFHEKCDRAVEDIKRLKLKTDGFAQQLNCDPNELKERFLNCMKQLDEYMYLITDFNIAISKLDEASATDNTPVHDTPAKPLMPTPMAPYNLIDALSEPAPSTSTSCSNNCPPEKPKRAKTPKENQPLIVFSSSSASEESVQQMKSEVAAKEVQCELDAELRNVKIEDPPTTSVATSPSESSNLPAQTILETEHVYDATIMHVDGTFFWVITEDPEEVKNLMIDMTKFYSEHHRDIDANEVKTLTCCAFYDDDSKCYYRGLFLKLNDEDNTLAEIFVVDTGEMRVAPVECVQPLYRRFCAKPPYARCCHLAGVDLVSYNNKSLMEKQEVFMSAYIGTQASIEVDDNTSESLGVYVILPSGETLNKIIVQQGLALPIDKLAGDQAAAGPSDGLDITDCPEYDDPVEAVTGYKNRDEIDICKHYKGGPEKTCFKGSRCTKKHILKHPDGWTLDRIAVMGKCKSIPLPAPDTWLKVLVTNVCHYDRVYVQIIDENENDEIPSFGVVLPATTLPALVRDMNSLATIAAYKPLMVAPAQGELVAALYPLDNKWYRARVLSVTRADQTVEVQYVDYGTVMWVKEDQLRVLEARHMALPAQAIRCALAGVKARSQLSQQWAQAKRALSEMLQDTLLDAHVIAREYDEITVELFDKDGYSIADQLAAINMVELTPYSVVYDTETHKVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR96</accession>
    <name>A0A835GR96_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein FAM114A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="62636" checksum="195C3F6FB1DCB21D" modified="2021-09-29" version="1">MATSDSEDFESADEGHGSPDKKERKKRLSSSNYSDNALETEQKASNTPKKSSKVQNVEENVKETDGWDDFDIDDTEPVPAPAKSNVQKQNKTVEDKPSTAKEIKKTQDTGWDDFDDWGEDDTANTAEKQEPKPIQSKPQPAQSQKPEPNIQEVTDRLAAASTGGSGWGWGWSVDSLLSSATAGISTITSQVSQGISTVLETGIGAPDPEELARRSVKNNETKTDRPEPVPEADKRPEEGSAQETSPGDAAFPFGSLISGVTKFVETTGTKVIHGGLDTLETIGKKTMEVLQDGDPGLAKKRAMLGLGTGDKPVLSQVLREAKAKAEEEDKVREEKREAKEVHYENLFDDFEGLVHLEALEMLSRQVSMRIEERIRSVDVDKRQDIKETLQQVAELCEMPEEDDDDDEESPSEDLSKPDAFHERLQTATQDLGLKLQFQALVNQYTDVLTYLSSPDSESVKAVYKRAVSSLAQGTALAVEQYHKAAEMLLVKTRRSTADEADALTQMTVVLTKHISELATLFTEKLNALPSDNKEQVNTYITNIFLEAGNSSTYIQNAFQLALPILQIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRV2</accession>
    <name>A0A835GRV2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase RBBP6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1320"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="932"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1382"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1489"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1512"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1544"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1568" mass="178863" checksum="34D1BB586255D0D2" modified="2021-09-29" version="1">MSFKSALDYDTVTFDGLHISVGDLKSAISQQKRIGKTSDFDLQITNAQTKEVYVDDHTLIPKNTSLLVARVPLSQQPKKQWEGSNSNQSSLHKDVAPNKGLADLSRMEGSEQDKINAMISQSTFDYDPSNYQKIRGQNQRGAVPSNYICYKCQKRGHWIKDCPAANSSDPIEIRRSTGIPRSFMVPVEGPKAPGAMMTPSGTFAVPAVDREAYLASESAGGADTPTNAPAAPEPNIPDELICSLCRDLLTDAVMIPCCGNSFCDECIRGALLESEDHECPDCREKEIAPTTLIPNRFLRNSVSSFRNQTGYSRRMPHRPAAAPVQQQPPVIEPAPNAQVGQPQSGPSQPSQSGGGPPLPHGMKPHGLEPSGVPMNLPRIDEQRASTPTIDERRDPMSSQVVYNRGPPPFIPGGPPPPRRYNSPFGRNLGPGGPRPYNDRYPPEPYQPPPPGIKDSPTNGHGEDPLEAFNRMIREKEMRAKRREEERRRAQSGSRSPRSRTPRSPRSPRSPRSPRSPRSPRPPRSPRPPRSPRSPRSQRSLRSPRSPRSPRLRPRSRGSSRLRYSRSRSISRGRLRRSPWSPRRRRTRERTLSLTRSPSPRRRHRSPLRYRSPLRSPLARSPLRSPVRSPLRSPVRSPLRSPHRPPMRSPPPRNISPHRYAGVYDELLSPPRRTIEPPYGARYGPRNSVPPPGYPPMGVKQMPPMGNINVPPEQPGYRGRYDAPPFEEIPPGVEPPVPGFEPSPFEKPPFGPPGPIERDRLPPPNYRDPYRPPPYNEGPTSYRDVSIPPPVPNEIPVHVGEQPPRYRDNYRPGHYRDQPMPFREGQTYREPGPPGSYRDPNFRGGPPPFRDGTYRNAPYREGGFRDNPPHNSFREPAAPFRPPSADPREPVSVNYHDPNYRDNFREENAASRGPNRPGFRNNVRNRAAPRRNANVEHDRHRDREVRERERYNDNRDPTEKSERPRDSERRAGYDKPRDGREDRAREYERVRDHDKEREHDKITPDKKVRVSPKRSRETREKKRSESRGRSRDRDSRREKKEERARDKSSADRSRDHKEKEKKLKDRKKKKREKEKDSEKKKKRDKKDKKDKDHVKKDDDEPEKEEVNKKNNNELNKTDNDKSADVKVENVNAETVSIKREKSPKTQSPEKQEKSDNDLYGDEVSGAVDKEIIENYVKAEEKDVLEDTINNSDNLNNSKEEPFDGIELQANADELDLKVDTEVSNPTSKEMLATLPELSKWEVDEDNVEKAKEPGEITSPEEEEDGSKVTSDVIKRAEKAIFAKAITSLRPIEIKKISSERLKLYDDEGQKPPMNNIQITVPVTDSESRSIEINEKKKRYSKTPPPRLSVKDRLGGKVEESRRGRETRIVQSTVERVKSRSKTPKREQPYRRVTVERERSRKQDASRIEMVKSERRLMSEAVKTGEKHRARSPSEKKYIKEDKKINTNENNGNRDRAQEKNVPEGKHTDRERKKSTLDEAHFEPDYDENVESDHELKEENPKKRERSASPADVSETKKVKLDNDTIKLDLNNVKKKPDSESESTSDSEYSSSSSSSDARKRASAAFMVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRW3</accession>
    <name>A0A835GRW3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vesicular inhibitory amino acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 32 member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Vesicular GABA transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_001167</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140800">
        <property type="term" value="F:gamma-aminobutyric acid:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000062">
        <property type="entry name" value="Vesicular inhibitory amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="20">
        <location>
            <begin position="172"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9423358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="579" mass="64805" checksum="43EDE123523D0C16" modified="2021-09-29" version="1">MYRSGYRAPSLRRVNLTTPQYDPPCRAAIPKKWVKVKIFKMINLGKFKLPPLRNVLDVTMQTVRQQMPEKPGAPPRPPQNVRFANLDNMGESCELSTMNETTSPTYQSTNPTNPFLSGALQAEDSFTSYQNTYPQQDGAPRTQSMQSVDFYASSEEGGGFEEGGGPPGAKINEYQAAWNVTNAIQGMFVVSLPFAVLQGGYWAIAAMIGIAHICCYTGKILVECLYEDDPVSGQRVRVRDSYVSIAKECFGRKYGARIVNIAQIIELVMTCILYVVVCGDLMIGTFPDGAIDTRSWMMLIGIFLLPLAFLKSLKSVSMLSFWCTMSHLIINAIVLGYCLLNIGDWGWGKVKWTLDFENFPISLGVIVFSYTSQIFLPTLEGNMEDRSKFEWMLDWSHIAAAAFKSIFGYLCFLTFQNDTQQVITNNLRSAGFKGLVNFFLVIKAVLSYPLPYYAACDLLERALFRGKPKTIFPVIYALDGELKVWGLAWRLGVIMFTILMAIFIPHFAILMGFIGSFTGTMLSFIWPAYFHLKLKGNTLESTRIAYDYFIICLGVLFGVIGMYDSGSALIKAFKIGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS65</accession>
    <name>A0A835GS65_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="112" mass="12453" checksum="3886E4F43417C14A" modified="2021-09-29" version="1">MMAILGKNLTMVFGRGRLRCVTTSQRFADTPPYWIRKARETSDINMEALSKNLIAQHKATAKHTKSRALSSLWPPSFCAYAEQGRGRDDRQRPAACAGASLSQFMPAIPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSP7</accession>
    <name>A0A835GSP7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01215">
        <property type="entry name" value="PTB_Dab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000262">
        <property type="entry name" value="Disabled, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048561">
        <property type="entry name" value="Dab_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47695:SF3">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="875"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="960"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1348"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1232"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1251"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1430" mass="159769" checksum="9AFA7976FC2C8E3C" modified="2021-09-29" version="1">MFNHKLPTDFPMQTLRKKTSPCKYKNEPGRFLGEGVSFRAKLIGVLEVPEARGDRMCQEALADLKMAIRAAGEHKQRIQVHVAIDGLRLRDDKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDTGHRFFGIKTDKAASQVVIAMRDLFQVVFELKKKEVEMAKQQLEGKTVTSSLVRHATNASTESKTKSISSVGETSSTTAKTADVGAEGGVAELVDLEQELSSLRRGLTQVEGLTPSNDPFGDSFTTLPSQKGLLPPPPSGASTRGRSTPAAPTSARGVFSPGKAAPALPFDLATVAAEFEPTPALVDNLAEPPVCQPSASTTQSLSYDVFTELDPLGTGRSKPYVDKKLFFQELKNPPKKVLKDLVSTQSLISDILPVTTDTKIEHYGPATTMTSLSRHSGGSVAIVKPTQTAMFSGNFFSADPFAETDPFDNTDPFSDSFKDDPFTSMQEFPKSSVLRVDELKSKLGREATLDKSEPEPNVFNGPLQVSLPPEPAPKSPRLQRQSTEGSTVRQRPQAHKLSAESASPPPPLPPKKVCELGGARPPPRPPHDHEDEDVGPPLPKPAMRREPLADRSMKPRLSSGATYSSEDEYLTPAPPPLPTARRFDITLSQLLTCTMDELAHRLRVPATTLSSMTLPQLTEYLRSYLAADNDRAHIHVEPAMKTEKEKPIPVISALPTPSIQQLEKPTTVANDFKPQFEDNFTPPADISDTFVANFDDFDKKANPSYDRYAAFREIQEEELKAKSILDPIDALESEPKQDSDEKELTAIDNLMRANQERENDGKEPARSPLKTLDELTLDSFNMFRNSVSPKPSQIDAKIEDIKSVMKTLQIEKSRRSVSPRDNGHVDVKLEDTNDRYAALREITITEPPQDEFESLPPELPKERKRSDEKSDGFDNSDFFDCIDNSSLSFTHVEDAFRKSPIVKEREEEKKVEEKKEPVVEIVPLPVRDLAPPTRLSTGSISDVVSGSSPDTKEKLGPVVVGAGCRAGSAGAGGGARGGRWAPLGAAPPSAGSSDSRDSEPRARPRRRHHDPPARAPIVQTSSSSRDVSPWDEELPPVTRLQRPPSHRDRDSRHNSSGSRECLDSGSGREKEKIRDKRDMRDRERDMSRDGRDSARDRRDSARDSGSGRDRRDVSKERDHRDHRDRRDRRSRDRENDSWDRDRTYSREREYRDSRSRERLPKDYRDKDRDRHRKPRHSYDEDEEYGSTLGWSGRRSGPRRSSSRERETARDPPRESRRRAPRDDSRRPRDYRFSNDFSPREREHTSPFDNDFHDTPTPTGKKRAPYSTLEGTRFAFEPEDVTASPVSVSSARARDIEQSATRFRFDSDSISPRSMFEDDFAAAPRPRTASIAEEEEGDLPPLRPRPPPSNNRDIRKSDSINIFTRESDPFEGDAFFACTGSDRAARRENWPGDFQGFDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU54</accession>
    <name>A0A835GU54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU54"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="239"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="37071" checksum="B0190ABE565CA5CB" modified="2021-09-29" version="1">MNTYVPVRKIIKAVSTQRCPKCLESVKEKRRRRWRWKPWLVLICLSGALVYFTITKQVLDNTHHENTEKLPSDNYYENLQTTSTDALSYNVNITTESTTKFPLNLTSVNISQENSYPNVLKGGSYHPPDCRNRFRVGIIVPYRNREENLGIFLNNIHPFLIRQKLDYQIFVIEQHGNGPFNKGRLYNAGYKEMIKFNKFFCIIFHDLDLLPLDDNIMYNCPTLPRHMCAYVNDTDIRRDYNITYSYKSLFGGVVSMTIDQFVRANGFSNLYFGWGAEDNDMFWRLHAAGYPVVRYQKSVGMYLVLPHKREPANPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUJ8</accession>
    <name>A0A835GUJ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_007369</name>
        <name evidence="10" type="ORF">HW555_001174</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000292">
        <property type="protein sequence ID" value="KAH9640170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUJ8"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="9">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9640170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="262" mass="30684" checksum="93E438C1728DB4AC" modified="2021-09-29" version="1">MVATTDKKAPAEKKPVKGKEDSKKLPAVPESVLKHRKRREALRTRRLQVTLKRRSSAIKKRKEIFKRAEQYVKEYRIRERDEIRLARQARNRGNYYVPGEAKLAFVIRIRGINQVSPKVRKVLQLFRLRQINNGVFVRLNKATVNMLRIAEPYIAWGYPNLKSVRELVYKRGFAKVNGQRVPITSNTIVEQKLGKQNIICVEDLIHEIFSVGEKFKYASNFLWPFKLNNPTGGWRKKTIHYVDGGDFGNREDKINELLRRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUL1</accession>
    <name>A0A835GUL1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000003">
        <property type="entry name" value="NAD kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="415" mass="46357" checksum="0D3F423799368AFE" modified="2021-09-29" version="1">MLRRQFSHESGKTELVRAREEYFDRRRTRSLNAPSPIQQFGPCGRIMKNSAMVMQIQDPASQRLTWYKPPLTVLVIKKVHDATILAPFVQLVHWLVHDKSMVVFVEAAVLDDRLLAEYGDFTSVKERLMTFRAGTDDLTDKIDFIICLGGDGTLLHASSLFQQSVPPVMAFHLGSLGFLTPFEFNNFQDQVMNVLEGHAALTLRSRLQCVVLRKSRDDKDGKEKKKPTTILVLNEVVVDRGPSPYLSNIDLFLDGKHITSVQGDGLIVSTPTGSTAYAVAAGASMIHPSVPAIMVTPICPHSLSFRPIVVPAGVELKIALSPEARNAMWVSFDGRSRQALQHGDSLYVTTSVYPVPSICAQDQISDWFDSLAECLHWNVRKKQKQIDELSDLTHSSSDNLEDLDQNHHDERPVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUU5</accession>
    <name>A0A835GUU5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 10">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 10"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUU5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="63141" checksum="13526EF17E0525B3" modified="2021-09-29" version="1">MNVARYCRVATTLIQRIMKMDASTATKSIKEGKAEICLTTEKVFYNPVQEFNRDLSIAVLTIFTNEYKAEQLAKAEKRGKTQNTTEGIEETQTNNEVDISILEALSATGLRSIRYAKEVPNVTKIVANDLSKQAVETIQANIVHNQVENLIETSHDDACMVMYKHKHPMKRFAAIDLDPYGCPSVFLDSAVQSVQDGGLLLITATDMAVLAGNAPETCYSKYGAISLKTKCCHEVALRIMLQCIESHANRYSRYIVPLLSISADFYIRVFVKVYTGAIHCKKTTSKLSMAYHCTGCDNITLQPLGGFKPNPTEKNPTQTKAYLPAAPPVGEFCTNCNQRHHLGGPLWSAPIHDEAFVTRVLNHVENNPELFGTAKRIAGVLAMVREELLDIPLYHSMDRLCGRVHLETMPMLVMRSALLNAGYKVSYSHASRMSIKTRAPAHVVWDIIRTWAKTHPVKPAKLEADPVARFILAQEIKTQVDLNERADANPISRRDGRLRFQYNPTPHWGPGSRAAVNVGEEKMSKAIRNQNKYSKDKDKKNLKRPHSPSDDEEIKNVDTSSETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWV5</accession>
    <name>A0A835GWV5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWV5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033011104" description="TM2 domain-containing protein" evidence="8">
        <location>
            <begin position="32"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27495" checksum="F0CF01A6716BB83D" modified="2021-09-29" version="1">MPRSLPLRISIRDCFVLVLLVIFNTIHITDMANNHMDVQSKENKIKDDSNDKGVNFSDNEEYLKSCHFVDQDAPECSSLLYPCITCDRSIDCRYGGLYNYSCTVKPKIVCNGSKTFNRTAMCRFCYQTEKWEHRCDQKANCNSLASPLKFYLTNCTVSDDVLCLGKRRFLKKIQCSWTAGTRWGTAVILALTLGGFGADRFYLGHWQEGIGKLFSFGGLGVWTLVDALLIGIHHLGPADGSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYX7</accession>
    <name>A0A835KYX7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000330">
        <property type="protein sequence ID" value="KAF9409205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF106">
        <property type="entry name" value="CYTOCHROME P450 4G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9409205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="101560" checksum="BCD6330D4094F383" modified="2021-09-29" version="1">MIEMAPFVDDTVYVDWSTRIVFYALVAVVSGLWMIHRWQQQSRLFRLGNVLPGPEAVPFFGNALLALGKKPDQLVNIWHRNTRVAWHKLIVFLLDPEDIEVILNSQVHIDKAPEYRFFKPWLGEGLLISTGNKWRSHRKMIAPTFHINILKSFVGVFNQNSKHVVEKLRKEVGKTFDVHDYMSTATVDILLKLQWVSQEKLKMNQVLTMRWLMCDIIHQRHYKFWLRFDTIFKFSSFFEKQKQLLGIIHGLTTKVIKNKKQTYFENKDKGIIPPTLAELTRNEEDGSLLANDAKTLSDAAYRDDLDFNDENDVGEKKRLAFLDLMIESAQNGTHQLTDHEIKEEVDTIMFEGHDTTAAGSSFVLCLLGIYKDVQAKVYNELYDIFGDSDRPATFADTLEMKYLERVILETLRLYPPVPVIARKLNSDVNIVTNNYLIPAGTTVVIGTYKVHRSPKHYNDPDTFNPDNFLPENMANRHYYSYIPFSAGPRSCVGRKYALLKLKILLSTILRNYECTSTVPEKDFKLLGDIILKRSDGFRLQIEPRIRKPTNSIKSTMTSLVDETEVPSYNTRLIFYPLLLLASSIWILYRWQQKSRMYKFAEKIPGPAIVPFVGNALIVLRKKPSELVKLALEYGERFGNVVRVWMGSNLIVFLTDPNDVEIILNSQVHIDKATEYKFFKPWLGEGLLISTGEKWRSHRKMIAPTFHINILKSFVGVFNQNGKNVVEKMRPEMGKEFDVHDYMSGVTVDILLETAMGITRKTQDESGFDYAMAVMKHYKLWLRFDSIFNLSPFFKQQKKLLDIIHGLTNKVIKSKKETYLENKAKGFVPPTLEELTRTPDDNVLANNDKTLSEDVFKGYRDDLDFNDENDIEWNQQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ04</accession>
    <name>A0A835KZ04_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000464">
        <property type="protein sequence ID" value="KAF9407500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ04"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF494">
        <property type="entry name" value="GH04538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="46"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="452" mass="49884" checksum="ADC163B3A67A9ABB" modified="2021-09-29" version="1" fragment="single">MAIITENGIYPSTISISTINTKCKENDLEMNNYDPFQNRKLEHPNSDMRSFANLLKSSLGSGILAMPAAFKNAGTIVGIVGTIILGYICTHCVYLLVKTSQDVSRVTRVPSLGYAETVEAVFATGPQPLRKVSRAARIFIDWAMAFTILGACAVYVILLVESVKQIVDVHFVGNGISTTMYCLMFLVPILFFTQIKNLKYLAPFSGFANVLLVLTFLICLYYICSEFEPIDSKPMSVDIGKLPLFIGTVIFAMEGIGVVLPVENTMAKPNHFLGCPGVLNITMSVVVLLYMIMGFLGYVRYGDAAQGSITLNLDTKEIPAMVAKVFIVFAIFFTYTLQFYVPMEIVWRNTKEHVAQKYHNLAQGIIRAVFAILTVAAAATLPRLEQVIGLEGAFFYSFLGLIAPSILDVIFNWERGLGKYNWILVKDIILIVFGTFVLVAGVTQSLREIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1I3</accession>
    <name>A0A835L1I3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000226">
        <property type="protein sequence ID" value="KAF9411406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1I3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="26469" checksum="677B69805FAF6AC8" modified="2021-09-29" version="1">MIIDLSVIGAVTPEVRRDGNERTSYAVKSYFEWPGSKFILLMFLQPSTNEITDAFLISDAILVIAQMEKICILERAPPVIHLKNNLRVEDTASFSKVDEAPPATAAGSYKFKLKEKGTISSRTNQLKSLCPFLDKLDIMRVRGRLEKSQLDEQVKHPIVLPHSSHLTHLIVSDAHERTLHGGPQLMSNFLSWHHILSDIGVHIQVFLQHVVQKCGQRLFWFLHVEMGALGKTLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1P9</accession>
    <name>A0A835L1P9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051440">
        <property type="entry name" value="Goosecoid-like_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="90" mass="9813" checksum="548DF50ED876A8F4" modified="2021-09-29" version="1">MPGVSGVGSAVSSAGGYAGLYGGYAAAALAGLAGPPPKRKRRHRTIFTEEQLEQLESTFDKTHYPDVVLREQLALRVDLKEERVEKPIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1U4</accession>
    <name>A0A835L1U4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase NRDP1</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase NRDP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HF086_015235</name>
        <name evidence="15" type="ORF">HW555_009422</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000209">
        <property type="protein sequence ID" value="KAF9411887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000724">
        <property type="protein sequence ID" value="KAH9632203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1U4"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16634">
        <property type="entry name" value="mRING-HC-C3HC3D_Nrdp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000268">
        <property type="entry name" value="E3 ubiquitin-protein ligase NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015036">
        <property type="entry name" value="NRDP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037255">
        <property type="entry name" value="NRDP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08941">
        <property type="entry name" value="USP8_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160088">
        <property type="entry name" value="NRDP1 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9411887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9632203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="315" mass="35852" checksum="883C74DC6EEA6924" modified="2021-09-29" version="1">MGFEIKRFQGDVDEELICPICSGVLEDPLQAPACEHAFCRACITEWISRQPTCPVDRQAVTASQLRPVPRILRNLLSRLCTSCDNAPHGCNAVLKLDSLASHLVECEYNPKRPMPCEAGCGLVIPKDELAEHNCVRELRALIATHQGKLNDYEQELAEQRLVINEHKRELALLKEFMRAMRLSNPSMRALADQMEREEVVRWANSLSRARVTRWGGMISTPDDVLQMMIKRSLSESGCPPHIIDDLMENCHERRWPPGLSSLETRQNNRRLYEKYVCKRVPGKQAVLVLHCDNTHVDEHMMVEPGLVMIFAHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L236</accession>
    <name>A0A835L236_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000749">
        <property type="protein sequence ID" value="KAF9405394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L236"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="51" mass="5754" checksum="E717FD5F545C1ACA" modified="2021-09-29" version="1">MLSRSQKILGMVGAKFGHTNKYSRVSLCMAETLDLEKLKTKTNAVMMLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L363</accession>
    <name>A0A835L363_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3 8">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="JACKWZ010000521">
        <property type="protein sequence ID" value="KAF9406999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L363"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF69">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="10">
        <location>
            <begin position="169"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9406999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="276" mass="29551" checksum="32BB2F931D31CA9D" modified="2021-09-29" version="1">MGEFKLGFIGGGNMSTAIFKGVLKSGVQSASDIWVSGPHIENLHHWSDMGANVTTNNKTVFMNCDMIFLGIKVTKLSEVFQSIQHPKQLNKEVLFVSMLPGILINDLHKMIKYSLPLVKTTVLRIMPNTPTTIGAGICLYTPDNEVSVEQCSRFKKLLSGSALCEEIPEYLMDALGALTACAPAYMYVVIEALADGAVKQGVPRATAMRLAAQMVVGSGQMVLQSGKHPGLLKDEVCSPGGSTIAGIAALENGNLRATLINALEASTIRNKELGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3X3</accession>
    <name>A0A835L3X3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000410">
        <property type="protein sequence ID" value="KAF9408067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF37">
        <property type="entry name" value="HOMEOBOX PROTEIN SLOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="20905" checksum="EE3BF87644D8DE96" modified="2021-09-29" version="1">MIKDHLQHSDIEADEVETDDQTSNLDDDILTQSDLDENGDPKSPTSSSSKKARAALRETPKVAQSLEEQEQRSLMSSWFLWRISLRQRVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGMDVNSPTVPPPSAGGFPSGPYPGGLLYSHGVPYPFTGPGPYAPYFHHLAANHHHSHGSLGHSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4L0</accession>
    <name>A0A835L4L0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_010750</name>
        <name evidence="5" type="ORF">HW555_007257</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000946">
        <property type="protein sequence ID" value="KAH9627598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4L0"/>
    <dbReference type="OrthoDB" id="6593286at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032706816" description="Cuticular protein RR-1" evidence="4">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9627598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13912" checksum="5539D4AB3352C8EF" modified="2021-09-29" version="1">MRVLILLGVVAVALSAPQGPAEKVIAIVSQEFDQQPDGSYRYSYETENGIKAEEAGTLKKASGPDAGDVIVAQGGFSYTAPDGTVINLNYIADDDNGFKPEGAHLPTPPPIPPAIQKALDYLATLPPPPPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L568</accession>
    <name>A0A835L568_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_004011</name>
        <name evidence="14" type="ORF">HW555_004724</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L568"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9418436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9630720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="506" mass="55752" checksum="C922EBDBFC9B7ABA" modified="2021-09-29" version="1">MVVRQYNEELKYLEKINPYCWKIKMGFQPNMNVEGVFYVNSTLEKLMLEELRNSCRPGMTGGFLPGVKQIANVAALPGIVGRSIGLPDVHSGYGFAIGNMAAFDMGNPKSIVSPGGVGFDINCGVRLLRTNLHEKDVQPIKEQLAQSLFDHIPVGVGSKGIIPMNARDLEEALEMGMDWSLREGYVWAEDKEHCEEYGRMLNADPSKVSLRAKKRGLPQLGTLGAGNHYAEIQVVDEIFDKYAAGKMGIERIGQVCVMIHSGSRGFGHQVATDALVQMEKAMKRDEIDTNDRQLACARINSVEGQDYLKAMAAAANFAWVNRSSMTFLTRQAFAKQFKMAPDDLDMHVIYDVSHNIAKVEEHVVDGKVKTLLVHRKGSTRAFPPHHPLIPVDYQLTGQPVLIGGTMGTCSYVLTGTHQGMTETFGSTCHGAGRALSRAKSRRNIDYKEVLEKLENMGISIRVASPKLVMEEAPESYKNVTDVVDTCHAAGISKKTVKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5M6</accession>
    <name>A0A835L5M6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032377712" description="Laminin G domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="2199"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="199"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="427"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="568"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="683"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="798"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="922"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1494"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1832"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2335" mass="262063" checksum="02587D1AE81502AD" modified="2021-09-29" version="1">MELILILSVVAAGYAYDKASFYGASYISYPLQEAKGVTDMSFRFRTHLADALLLLAAGKTDYCMIRLEGGRLKLHINLGAGESELSSPKGIHLNDSQWHHVSIIRREANLTMKVDETAVKKRLPGRFFELNIHFGIFLGGQGDFSELFLGHMENFRGCMEDVYYNGVKIIEKARSRSGSVHVEGVTWNCAPEFDADLNSDISFVDEGAYLILPRINSRAGGKWQIEFKTIAQNAIILYNAGGGRGSDFLAVEILEGVIRVKMARGQIVHTVRVNDGQWHKMHLSFYPSMIELTVDNIAMHTRIESGGTRYLDLSDSFYLGGIDSEKQQRAFTKGIKAADSSIMGCIKPIEVDEKIYGLPNAVVTYGVSPKCVWWYPCHSSPGNPPCVPQGVCEQHGVDHFTCKCDSDLCINPDYAEKYKVFSKSSSELELVALFPLTVQEGGVSVITTQNIDVVLDHHKYGVRPSGVLLHVAQSPQHGRIAIDLSLQRNSQQYNFIEGEPKSKQFFTLLDLSRDKVRYVHDGSENHQDAIVLDMELIPETKFTLPSYLQGRNTFVLHVNVTPVNDPPVLNLLPGKVLRLTQGTRKVITSDILKAEDPDTAPEDLLYTVLHGKNEANSGHIEMSGQPVDSFTQQDIDAGVISYVHGTTNDKQLNKTSLRLTLQVSDGIETSGPGILRISIVPLQVRLVNNTGLQLVHNSYAIISADNLTFTTNADETNVQVKYDIVKPPQFGVVERLRVLDGTWQTVDSFTSEMVTFGRVRYMHLLGNPSHDEFKFKASVGSIRTNTLYDFRLTFIKLELYQSVNEELVLNNTREAFISSQHLTFKTNPLALPSDRVVYTILRPPKYGILHLSSGKHHLQMHSTFTQQHIDTDQLWYRLHRRAYSHIQDEFTFVVGATECKNITGVMTIRHTPGTPSSDRTEGRVHTTLERLQVTEGSRMVIPATHLNFRTDAVTNLIFNITHLPKHGKIEVINDILKVSRDNTTYFTLEELNSDRVYYAHDDSESRHDSFHFMALSPEPEDFQYVGVFHIDIILKNDNSPVRANDNVFHIVHGGARLITARDLSYTDADLDTKPSDIIYTVQRYIKDPPNGGIFRADNPSEQIAQFSQDDINKNLVLFKHQGKEYGKMAFWISDGLFDVNGNLEIQASPPFIRMYPSNGSIVENGKAVVITSRDMQVDTNMNCLEEDIRYEITLEPKHGTIEVGEGQGAFTFTQLDVTASRVAYRHREPKTPTDQFRFKVMCLDTWGEGVYVIKIFPSSYWEPLRVTTNLPLVVEESTSVNITKDILEVMHPQIEPSNIVYQVTEGPYHGWLEITTTPGTLELENYNEEPVHIKVFDQSIINANRLVYVQSGVNRTRDRIRMDVTNGIVWLRDVELNVVIIPEHFYVHAYNLTVVEGEAVSVKPDLFRTITDYYKGKVVAYKVVEKPKYGKIVMADQELNLLPVLKLNSGNIQYLNDGSEESSDAFKLVAMTESSKESEPFYVHVNIAPVNDEPPIVAANTGLCVWEGGTFTFTTKELYVNDIDTPPENVTVRVVDIVSGYIAMQGNLDTAVHHFTQADIDKGKVVFVHKNGTKGKMIFNVTDGLHELSKITFLITTKSVSLKLTRKHNMKVFPLMREPLNNYMLMSKCSDPTRTIIYKIERAPTLGRLIMLNGESHHRSIKQFTQQDINNTVVFYEHTHPFSDLYTNDSFIFTIEAPLAKPLTDQIFNIDISVSSGGLAKYVNIPPIKVQEGDKVPIKVNVSNVITYLETQAGLRQPQIEAQWSQPSHGELKPFMSSLTQSQIESGVVNYEHDDSDTTQDKIDMALFLLPDYVLLCNVSIIIHITPVNDQPFRLLTDTPQIQVVQGENYTITKNDLLTEDADTGPAGILYDIISGPTQGRMVMLDKNQTIDDAHSINKFTQDDINNGRVVYEHSGILQTATFYFRVWDGQFKPTYTVFTIDVIPVILNATSLHPIYLQQGSNVAAVTTDQIYVDTNAKTSKVLYNITRQPLHGMVYVGRNPVSYFTHRDLMEKVVIYMQNDMTTANDSFDLIAYVHNSNATRPFTIEVIVQPLMTLGDLRVEVEKARITLRTMDASGLAKLTASDPVYTLLRKPRFGTLKKIIRSSGEKTSAREREVAYFTHEDVKAGVIYFVTKKKVNELNGFEDSFRFLLAATIFQPAVGDVKIIIGNRQKKNMPGPNDPESHEGVPVANGETASYYMMILMALSGTVLAIVVIFGLLKCRRYLMRDQNALVKIHGQSQGAVAPIPLPRPPEHLMPSPSQGTPPIKRYVSSEQSVHTGASTPLPSAGSVACKFGSLQAEDWSSYEASESAYPVRATGVAPANPMLRRNQYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5P7</accession>
    <name>A0A835L5P7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine-5'-phosphate glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5P7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9419202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="43910" checksum="544EF16F39D86FD0" modified="2021-09-29" version="1">MAYLAKYVLKGSRLAAFYKRGYSTASPWVFSEEVRLAKSEGKPIVALESTIITHGMPYPQNLETAKQVENIIRERGAVPATVAILKGQLTIGLSEEELTYLAQAKGVVKASRRDLAPIAAAKLDGATTVAGTIIAAQLADIPVFVTGGIGGVHRHGENTLDISADLNELGRSNTLVVCSGVKSILDIGRTLEYLETQGVCVCAFGETSDFPAFYTTRSGFTAPHRVGDALQAARVLHASRQMKLASGIVVAVPVPQEHAMDEKIIQEAINNALKEADRNGISGKEVTPFILAAVAKATSGASLNANIALIKNNAKVGADIAVEFKKLKNVDDSKNAFNIGSSKGAGKCTSNTSRHFHTSCSRRADESPLFSGDKNCGGDVLVIGGANVDRIYRLKEEGAQSPSAYLRKVVTTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5U2</accession>
    <name>A0A835L5U2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_002842</name>
        <name evidence="9" type="ORF">HW555_006961</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000298">
        <property type="protein sequence ID" value="KAH9639928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5U2"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9639928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="247" mass="28490" checksum="C653BC8163B20B49" modified="2021-09-29" version="1">MRSSFRFIRCYTTSTNSNNFAEEMKKNFIAANPFQKAILTVGSAAISLLNPHRGDMIACLGEVTGESALIHMQQKISETQEGSEILKEKPRINSKTVCFDKLAQMPENTLGRVYADFMTDNNITADSRLPVQFIEDPELAYVMQRYREVHDLVHATLFMRTTMLGEVTVKWVEGIQTRLPMCINGGIWGAARLKPKHRQLYLKYYLPWAIKTGNNAKFLQGIYFEKRWDQDIDDFHKEMNIVRLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L662</accession>
    <name>A0A835L662_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000235">
        <property type="protein sequence ID" value="KAF9411086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L662"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="146" mass="16368" checksum="82CE955612A2FBEE" modified="2021-09-29" version="1">MAAAKKAVQIRLPPLPSIKDVIKLYKLRALRELSQNFLMEPRLIDKIVNAAGNIENHTVCEVGPGPGGITRSIIQRGPRKVILIEKDRRFVPSLELIADACKNKVDVDIITGDILKTDIAQYIPEDAKTDWLECPATRQFNWELAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6I6</accession>
    <name>A0A835L6I6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6I6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="15594" checksum="2C5E68DDD2F596F8" modified="2021-09-29" version="1">MSTNAAQQIMKSLCVNSSSKLTLMAPISWASVNSAVASVSTSGVYPIRTPLFLHSATSIWSWPTEIVPMTFRPGPAASNTSLSILSVREQKIPFTPATAFKRSSLGIVDGCVDIFTSHLYNNESTYSFLSKSMPPCGISLRVTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6R2</accession>
    <name>A0A835L6R2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6R2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841:SF1">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="284" mass="32089" checksum="F0821880923F6E49" modified="2021-09-29" version="1">MSQNKQELRVVTYMCPTHPIQLYELILELLEEALGCYTTLQYESRSPGPLPDRPDPFSTNKVDLAFMTASAYIKLREKKNGNIELLPVTPVFAHQMNVENKPGYFSDIIIHSDKKAHNVNTLLDLRGCTFAYSDEESLSGSKIVLKTLKEKGENASFFGSLLRSGSHLSSAQMVLSKQAEWAAVDSTTLLFSKKFMYDGGKDIITLETLGRLPPYPIVVNAKLHEETKKAITNALLRLPQTQQWKNKFAKFGIIKFEVNSDVAYNGPATQMWAIQNEKLNVRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6R6</accession>
    <name>A0A835L6R6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_017944</name>
        <name evidence="8" type="ORF">HW555_003799</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9627969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6R6"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF154">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER-LIKE PROTEIN PATHETIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="56"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9627969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="470" mass="52395" checksum="CBA7DCCCAE4E7BDF" modified="2021-09-29" version="1">MVNEANGNAPAQQELETFLSQDEKKKEKVVNKYNMTKDVESADFDPFAERKLENPTSNMDTLTHLLKASLGTGILAMPKAFKCAGLVSGIFFTMLVALICTHCSYILIKCAHVLYKKTKRTQMTFPEVGQAALENGPQALRAWGNIFRIFILVSLFLTYFGTCSVYTVIVAKNIVQVVAHYMNQKEEDVEIRIFIIALLLPLIFMAWIRNLKYLAPVSMIANVFMGLGLGITFYYLVGTGKLMTDNIRSMLFKAPVEWPEFFSLSIFAMEAIGVVMPLENAMKTPRSMLGTCGVLNKGMSGVTLVYILLGFLGYLRYGEDVKDSITLNLESAEIPAQIVKISIAIAVYCTYGLQFFVCVEIMWNSIKDKFTKRPDLADYIMRTIMVTACVLLAVAVPTIGPFMGVIGAFCFSILGLIAPAFIEVITYWDIGFGPGKYLIWKNVVVLIFGLFALIFGTKDAIKEIIRVYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7E5</accession>
    <name>A0A835L7E5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7E5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002395">
        <property type="entry name" value="Kininogen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00334">
        <property type="entry name" value="KININOGEN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40001" checksum="730736094B96AC60" modified="2021-09-29" version="1" fragment="single">MRYISVERGLTSNKKYSRVTNSKCMQLYSGNTNLLVAFGLLAIAALSSAREIREKRDADLEAAASHGHHWDKGGGHEHHGHHHDEHGGGHHKGHKGHHEHHHGKHGHSHHEGHKGHHGEHGGHKKHHHHDEGYHDHHHHGEKGEHGHGHDEHGHWHKGHDTKGHHGIEKHDEFKKDKHFHDHHGEKGFHEHHGGHHHEGGYKKGGHFHKGHKHGGHHEHHHAVLALAALADARNLREKRDADLEAAASGHHHEKGGHGHKGYKGHHHHEHGKKGHHHHEGHKGHHEHHGGHKKHHHHDDGHHHEHHHGEKGEKGHGFEEKGHYHKGHSTKGHHGVHKLDEFKKDKHFHHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7G0</accession>
    <name>A0A835L7G0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7G0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="49631" checksum="8376874BE95351EC" modified="2021-09-29" version="1">MSKPEGVMEKSEEKFAGSAGVDMEQLMQELGQARRFHLGNYALLALTVFVAALYATNYVFLAADVPYRCVVPECEAANSSEYSPSWLAAALPPGNIESRCSRRAPLDTQLPCQEGTAFTHEVTLCDHWLYQANNTIVSEFNLACQEWKRTLVGTVHNIGMLISLPIFGYISDRWGRKRALILSSTLVGAIGSLKAFSISYEMYITVELLETIAGASVFPAAYILTIELLGQDKRVLTTAFLGIMLVLGGLAFALLAKTFQYWRTFILVAYPPSLLFILYIYLLPESIRWLLSKGRKEEAVEIIMSAAKMNKVTLSDETMKQLSEEKVKPVEKKDEKPEEGLWIQVFHSPIIMTRLAICSWWWITCTFVFYGLAINSVSLAGDKYTNYMLVVSVEVIAVVTNALVLDRIGRKRTLLSAYTVCGIACVAIPFVPKSKDFYKVFFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7S6</accession>
    <name>A0A835L7S6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7S6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="273"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="613" mass="64322" checksum="BDD5C59CCF52AD1A" modified="2021-09-29" version="1">MPNQSAGLRPQGRCRCPSTLIHFSSYSTTVRGTRMIVLRDFRFPASAHLWSAALASYSLFARHTAESYGQSGMAAFREEAARGGVCVAREVALRAAPTPAAVDAALARLARGPQVAVCWCEGRTARRESLAANYTQEPKLALVVRGVYALAHALHGMRRAACGRAGRGLCAAMLPFNVSQYRRHLARVRFRAPDGGLVAFDDSGDPPPECVTLPPPAPGCRLCPPGHHPDRDRIGTCQYCFCAALNILDACWKDECTTCLASGVEWGDEGRGTRAVAAMTGAAGLAAVATCAVTFWRHRATPVVKSASRELCALLLCAAAVCHGAALAAVLRPGPGPCAVVRLAAPALGGVYAAVLARTVRVARLVSACERRPAARPRLLSSRAQLWTWLALTAPGACVAVWSAITWPATPQLLHPGRSRSVLVCGGEQAPAQLSPLAPALALLAACVGMAVRTRRLPHNFNETRFVGAAAYATCVTWLAFVPLYAVSAARTATLCACVSVSAGACVALSLGPRVWVCACRPARNTRAHFLTASIRCHVGKYRAALEAAGARDVACQAEGGARCQAAAACARVLRTEGEEGGGDTADVVIVLLQHQHWLPAGSAPAVADLLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7U5</accession>
    <name>A0A835L7U5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase TRIM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_008443</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7U5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12889">
        <property type="entry name" value="SPRY_PRY_TRIM67_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000178">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="14">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="387"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="12">
        <location>
            <begin position="463"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9413277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="70810" checksum="C596118D2432F802" modified="2021-09-29" version="1">MEEEIRCFVCKEFYREPVLLPCGHALCRVCAVNLQTHIPEGDNSAASNDYQEADKASVSSETDSGVVCGSRPNSYAGTPAVPAYSSAAFTITCPSCSKLVYLDDNGAEGLPPFRVMRTIVERFGGVTGAPPAEEACQMCEGERRAAVVRCEQCSVRYCAGCRDAWHPTRGPLAQHELRPLGTTCADHGSPPVLYCNACLVPICQRCLAERHSTHETQALSTAARAHKTELSQSLQHLSEQAKAMTEYIQLVKGTGDKINESCEELEKQIDNACSEVTRAIERRRDELIRAARNTRSQAITNMRSLTSHAAQKLREATALLHFSIEALKESDHAAFLQVGNILSARAQETASNLCSSLDTPPTAPALTLDVEPVLRTVRSMNFVECIPPGAPEMAVEACAARGCSCTLAWRAPAQPHAVRGYVLELDDGLGGPFREVYCGRETVCTIDGLHYASLYSARVKAFNGAGEGPYSEVIGLQTSPVAWFTWDARCAEAEGGVTLSADGLSAAAAGWQPRVALADQPLARGLHYWRLRIDRYDGDADPAFGIARADVARDKMLGSDALGWAMYIDGSRSWFVHGGAHGGRAAGGIARGACVGVLLDLTRGTLRFTVDDQPQGDIAFTGLRGAFYPAVSLNRGVAVTLQPGLPPPPDLLISQLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L838</accession>
    <name>A0A835L838_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_003953</name>
        <name evidence="16" type="ORF">HW555_004755</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L838"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9418467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9630662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="469" mass="53789" checksum="99A69A36C6B138EB" modified="2021-09-29" version="1">MTYDWFESIGRPRFVVAPMVDASELAWRLLCRRHGATLCYTPMFHSNVFNKDPKYRKDNMVTCEEDRPLIVQFCGNNPEIMASAAKLVEGQCDAIDINLGCPQSIAKRGRYGSFLQDDWDLLKKIVQTMSEAVSVPITCKVRIFESIEKSVEYALMLQNAGCKMLTVHGRTREQKGPLTGVASWEHIKAVREAISIPMLANGNIQCLQDVYRCLEYTKVDGIMSAEGNLTNPAIFEGINPVSWEIANEYLDLVEQYPCPTSYIRGHLFKIFHKIFSLEENNEDRQILATAQNLDDFKRVCINVRDKYLPYHEGKINIENDENITRIGFNLILPPWICQPYVRMSPEEHTLKIEKLNIIQKNSAEKRKSEDNDGTILSRKKMKKLRRISRRPEKPDSQQNGRSGQICFSEDCPNPLGGKCLYQLCKKCCRNKCYEEELDCKGHGILVHTRREMARKFAKNVECNTEAAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8N4</accession>
    <name>A0A835L8N4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000134">
        <property type="protein sequence ID" value="KAF9414424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8N4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="813" mass="93470" checksum="A7833A455FE10A18" modified="2021-09-29" version="1" fragment="single">CTYVKSRCKMASITMQRDLVVSFKKETILNVGILSKLQQMPSDLSRLIFKENALEKPTQSLFNHLSYYLVSIIDNQVCSTLPWPLYDTKTERAYRNELSNFITDYSNKGLLSPVMSSYLVNPGCYKVTMLIFQMSQLAVQKVVQTKMINDSQQKLYDSMTDDYKSQKEGFIENIDKETMSMSNKFSNYLCKRSAMEKIAEMFRKKIVDMENKMAELNAQKYLDDIVDGYLKMHNVDDETKTEILKIKDVHKPAKFFDDWLLETDKAITQLEDEWDIENETVSSKINSSEMLIARQTGEAEKSSYTLEYNPKTDDICTKELQNQVNSEQRYILKNITKDDKLSFPNLIRAFLISICFILKNAEIGDEIYKFNQYLDGGKKNLAEIVSAMRMLVERVMTAEARLQPSEMYYNQSISLKEFSEIPPLPDLSDLKMGKDLQSQVIFDNFTPLNISKHQFNLRRRVQSFVKPPSRSMLIAPFYQGPKDDFLKSLISCRFSSYDRQNTTQNLNMSIISQVNYRNNETIAECSSGFTKQQIMRLLSTKKSSSSKKFKYKTERPDIQVKKGGLFNESVVSNDNVLFRSHSSPNLFENREKRSKIPIPRKLSIMQEDCPLLEVSGISVLEKDNSFGTPEGVPRLESTRKIFDATSLPAITVTPEPEKVISEKEDSNKVHFAELNVPKLQENILEECKTETPKTNAQLIRKTSSLEKIINRFKKVRASVLPMDKSNEEVNEFKTIAEEKENLNTVNVDVFTANRVLLPDLLGPSCSVIPQKLTEDYLEEFCLDDETPCRKPRESLGTALGVDNTFLDQFDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L971</accession>
    <name>A0A835L971_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L971"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="284" mass="31370" checksum="0750BCA75C434E0B" modified="2021-09-29" version="1">MGHAGHDVVPDEASSVLKGQEHLFHLDAYDEMDKVRNLNLEAIDKIKHFTNVIYSKTDNWAPIPYMEDLYKYQPELTMKEVDIDHAFVLKSSERTAEMGYKIRTNNTHTPKRDNTHRTQNDSSQTPGVTRRRRQDPRVALSSSITSAGRLQKRISELFNSISVDGRRRVGFLTQGSSAPRPAARLRLPDAFKSTSLILRHGFPRTETASLPDRSRLRKRVSVLSSSASDDASGDERSLRTMRGSNTAGAVAGAAGTMAGDCGACDGEGAGEARGRSEWDRARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9M9</accession>
    <name>A0A835L9M9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9M9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032456669" evidence="3">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="266" mass="30249" checksum="74530BB3FEE62C95" modified="2021-09-29" version="1" fragment="single">MTMWFMSYKFRILLSLVLTATYDVAKCDPIANKNFNSNIRDYAAADAINRTNVKTLQKEDLAKYATFTPASNPIKFKEIPDSALSSSSNGRGLYHDHSGYTLNEYEEGPHYTHGHDYHLYDPHSDGHGPPSFDHDYHGYHHSDHNDHHGHHDSHDHHDYHDSHGHGHHHGHYDKHYKHALATKAVLWPIAGIALLGAAAALVSNPVLLQLGVISGKRRRRDTEEITGPDFTSDMFTKYEEKLKEISDEGKKIQIKKNLTSKTKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9P0</accession>
    <name>A0A835L9P0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9P0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="18290" checksum="7678A5BD1C67F508" modified="2021-09-29" version="1" fragment="single">GPGVWKVIFIEKCDQHSHKFIFDIKQKKINRTHDGFYGDLKLDELFDDSFGIRVDICKHVDGGCKQYQVLSDDCFINFVNKYAEENAKDALACAGVVPSEFPIKEGDYEIHNYVFDYSELPTDGWYGVFCAKAIVLKGTEEVGCVEVHVEFTKKEDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA62</accession>
    <name>A0A835LA62_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HEAT repeat-containing protein 5B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2025" mass="218597" checksum="2BA63510A1C9EC30" modified="2021-09-29" version="1">MEVSHSLTLNESALQQLPDDKKPHFIFEWLRFLDKVLVAAHKSDIKSCQQKLVAQLVNLLRENLGGPARRLLARNLATLFSVGDTFLLFDTVNKCNDIIKVKDDSPSYLPTRLAAICCLGSMYEKLGRMMGRSYEETVTTLVRSLKNAESQTRLEIMNTLEKICVGMGTAAPAAVREVSRAARAALVSERATAVRAAAAHTLRHLLPLMRLTPADLDAIAAACLRAAQSSDYSLRCAIAELLGALIAITQAGEVTNLNSKLKTGAPSVQQKKDPPKNVVSLDEALNLLMGAFLRGGTSFLKGEIIKSSSGVNREVRVCVTHAYVIFVQNMGGVWLERNMTTFLNHVLDLVANPKAASSHVDAVYSRKCINFILRNTLGKMLGEKAQSSACREIIQIVIKQMNSIDFNPENAKDCNQETLFSQHLLVCALMEAGELALQLGTSVQNLVSDTSLNMIDAICTVLSHPCVAARLAAAWCVRCVCVALPAQITPLLDRCVDALDAARPTPHHISGYSAALAAILGAVRLSPLGIPHGRGKVAFNAAEQLLRSAGQSSRLTAARTNAGWLIVGAICTLGVPVVRGLLPRMLLLWRNSFPRSAKELESEKSRGDAFTWQVTLEGRAGALSALHSLLIHCPSLVHNDDTAKRLTQPIDGAIAVLTNVSTVVRSYGGALKAPAALLRLRVYQACYALGGGGSPPPAPLLRLLAAELAGSADPSGANVATGTLRNAMHPRDTILLGEEGWIYDTDHAEIEDQLMSPLSASGSGALEHDPCCLYRGHTGAQPLGVAVIDASVLLFPQIFSRAANKHRQQMLEHFAECIKMSKGARQEAIQINVIHCSFARIEDLSRTQELARTGGPNSATVRAAAASCAGRLCGCITEAESQALSEKVIAIARTAVNRSVRAAAAAAVGAVQRARGATSSAAALPVLRALAQDTAAVELQVWSLHALSVLADASGPMFRGHVESTLNLALKLLFSAPPFQEDLHRSIGRLLSALITVVGPELQVVAVGRFVCACAALFECGGGGARAEATGCLQQLQMFAPDHINLHTLVPQLCRDLSSSDLTVRRAALCCLRQLSQKEAAEVCKYALMAKDHVPARPYCGVVITETGLPGALFAFLDSERDPTALSYARDTLTCCLLAAATHRSVKDWLVLAKRVLTIRLEDNNNPDTDFDGEGDDDQAEFHAESEQSTHPAVQSRWPTRVFAMECIQKIMGACEATGDSAHFDLVKAKEKLQNQPDGDYLSLHLSDLVRMAFVGATGESDALRLCGLKTLQMIIQQFARAPEPDFPGHLLLEQYQAQVGAAVRPAFSGDTASHVTAAACDVCSAWIGCGVARDINDLRRVHQLLVSSLDKLNTKGNTTLIYNESMATLEKLSILKAWAEAIAMVSNGSAPGSYVKHLDTKPFNNKAELARWRNQLLQNNNQIDNATPETPEDEGERVLLKLVEPELESLGENWIAALKDHALLSLPPEFASQLPHGGGAFYCAETAEASRLHYARAWPELLYAAALRYNKGGALPADKSEGALDNRSSKTENGNFEFFEPIDERFHLLFGICTEALCAQRDMSDENIISVLLSLVTLLDAPENRARLLKDRALAIELCQIIHRTGLTQESIEALLLAADVLKLVIEGAKEQLHANMQAKIKELAPNEASDGTTPQSVLEVVHTLGEGGPTGDLPPGKSVVFACLEACLCLLVRRLPALSPKKQGGAIGVIGVPKGLGVHGDTLLVKTLTAMSELPSLTSPQGALSILPTILYLATEILRESRGQGVAAECGVLLLQGAADCPAPRLHAHTAALHAKLLQSALAKLVERVKSDDPDQRIEPIIGARGMAVVLNKAGPAPPLHYPCINHFRQCLETNDNEVFTSCCAVLRIKMLWLLVPIVISYLREGAELQRAPAHVRALHEFALHWLTKVGPKHPQEFKTMMQQSSELRNKLENALKANQATARSGRTAQTQRPVFDAKPAKPTIQLKTDFSDFSWILANFSICISQERYLIFLVSTSGTRIIAYYKFSNVNQQCNIFSILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAC4</accession>
    <name>A0A835LAC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_002305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000080">
        <property type="entry name" value="Putative activated CDC42 kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="453"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="716"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="781"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="956"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="883"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9421865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1274" mass="143772" checksum="5751D280B754761E" modified="2021-09-29" version="1">MRKSIMKKRIDKIMEGVQLQRGEENMEHEETINEKKSDQPGETKEIESCKKKALEEVDQYGEEIKETTLEKDDQYGENISSGSEGKETGLSPTILDFSSGSSDDFIPNSETDSTDTSTSTGKPKKRYTKKLIIPESSDDSDSTTSGPEPGCSHSNKKQRKSLKERRADRQSRLMLRNAGKSYVTKLGKMKPERNLGPLTDCRMKCNIRISHDIREFIFKEYWGLGSYDERAKYTERFIKINKKKTHTIEGKGKREYSNTYKIVYFDEDYKICKSCLLKTLGESNRFLQTVCEKIKKYGRVTKSERGRAASYKKISNERLKDVEQHINKFPAYESHYSRSKTAKKYLSSDLSLNTMYQLYCKENSNPVCKTITRLAHFDYVHAEDLEKLGISKPGVRRLFDAVRKKKLQLWNRKFWNKLFGSSSSSVSKEKTDLAVRTPQADSRTTCIILEKDIILHSEIGNGSFGVVKRGEWRVSEHPSQTVPVAVKVLKADAFSQPGIYDDFRREVEAMHSLKHPNLIKLHGVVFHPLMMVCELAAMGSLLDYIVAQNGKVSLNYIYKWSEQVASGMAHLEKHRFLHRDLACRNILLSSVDLVKIGDFGLMRALPDADDCYVMSEGRRVPFPWCAPESLRSRQFSHASDVWMFAVALWEMYTFGEEPWIGLNGSEILRLIMREGQRLSAPNACPPDVYMLMMQCWDLNPKERPTFAGIQRYIETNKFETAIAALSYRRPGKMTIDAGDAIILIDKRPELHWWKGQNQRTLEVGLFPSTLVTVGLKSAKNNQAAKKSQTLTPTQRAQATSNTSSSNGVSDDMAVVLRKRRTIESTQPSTTRGGNTGSKHFNYNKLTNDRVATLAQERAARHTRDAHSKSLNQVKEDILIDLDLPPSTRLSTPSKKSSPSSPNVVSILDEPIDVPEIGLDSDWGEQSIESLPSVSASYNLQNYGMYGAKSLDNLSTPLHLSTPPAPPQPDPFDTSQFWPSNATRPNYDITESNINSISKQLQESHRYSSSKQSSSAETSHIYNNMPSTSTASANNTYGNTPSPYAMNNALSLERNVTAPSVTASLADMSLDDRISESLNLRSKSNNSDYLYSDSIYNAPSTSAAANNATEDKKYGDIPIYKNYDITPVQQQFILETKDYYTKLSTPSKANTSNDYEKNIYVPKYEEDGEKLKNFSDCVENSKNYSAYKYQNVDYQYSNYDSFRGSLASTSRGGTAVYDEVNDTTSNFYSEIGEPAGSSLYAAQPVYSNSNLYDEVYEDSVPRPHRPAPPCPTKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB69</accession>
    <name>A0A835LB69_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB69"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="87" mass="10471" checksum="C1815EBFE2A1B532" modified="2021-09-29" version="1">MYYNSHKNTNDRILDLVLSNNYLDVAKCSEPLVSEDPHHYHRKFKKYGNRCDYDSFSALRDRGKILEREMFADYIDTIEIKNFFPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBD1</accession>
    <name>A0A835LBD1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="9160" checksum="4B79E9047B0618A0" modified="2021-09-29" version="1">MRFFLRRMLNLTKPKACGSCLLGQKLLWVYLCHGFIKNTAWITLGNQVDGVRLVDPDLIGAFKKRYPDGNCMAPPPPDPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBF5</accession>
    <name>A0A835LBF5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBF5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="9445" checksum="ED8E0B02FB4FBC3F" modified="2021-09-29" version="1">MIYVIMKSSSLVIIFELQIENKLQTRITWYCFEPGEGRPKTNNIDHTRKIRNAKIKFVTFMSVFNRAANKEPGEVVALKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBR3</accession>
    <name>A0A835LBR3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000058">
        <property type="protein sequence ID" value="KAF9418252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBR3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="472"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="687" mass="79701" checksum="B9311AE899D59F0D" modified="2021-09-29" version="1">MVAPSWYNRKFPGTVSRVLTGDGGAAVAFGDPQEGVRLWEARRMLEQVCETSLQVQRAHGRATNRWKRGYTLVAIHTLFCINNFRRYRALDQNARVCTLICNWVYPQIITEDDYICEACWELAMAAVNQNLQQDISVSDEQAGQSQRGHINVCLLCGCSIVRRQSDKILRDNPTDLQQNMINIIQMKLQPRQVTPTDRVCHACWLRTKREALRSNLVDENRIPEEILQMEIMPQDNEPHENPQEELARPNIIESITLTDYRRAANTGNHCVFTDCSNTDTLHTVSDQLRAIILSNHKYYLPKLARVCGDHLDRNSWDSLFESSNSINTFNVDQVQHIFSFVNAFNPTLDFDNVEEMDERIFIYWVGFSKEKYNMLLAEVPRISEIKGGRLGLVSLLIKMRSGDSDERIATLVQKPRRTLETLMDRVREVLVQDFVPRYLGITHLSREQLNNHTLAIPNGLYGHENNVIVICDGTYIYINKSSNYMFQKDTYSLHKYRNLLKPFLIVASDGYIIDCFGPYKATTSDAEIMSSLFQTETSPLRLYFRENDVFILDRGFRDCISLLEECGYRTYMPDSLLEGEHQLTTAQANRSRCVTICRWVVEVVNGYFKRDFKILRQEYFHRSLPHMMKNFRIAAALLNKFVTRLRNNDLRGSEETTLIRGRIKSRHISRKQYFVYILVENNNNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBY6</accession>
    <name>A0A835LBY6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NUBP2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_004670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBY6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9418521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="258" mass="28031" checksum="73B4C0DF7E652E08" modified="2021-09-29" version="1">MLDSVKRVILVLSGKGGVGKSTVSTQLALTLKERGYKVGLLDIDLCGPSVPYLLNLENQNVHQGPEGWIPVYLDNEQRLGVMSIGFLLSSRNDAVVWRGPKKTSMIKQFLEDVCWQELDFLVIDTPPGTSDEHITVMENLRQVPQCGAIIVTTPQEVAIEDVRKEITFCKKTGIPILGIIENMSGYECPNCSECTNIFSSGGGKSLADISKIPFMGSVPIDPRVGKLAGQGLAAIKELPDSTTSKVFTELVNQLALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCG9</accession>
    <name>A0A835LCG9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cyclin-related protein FAM58A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin-like FAM58 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCG9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20535">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048053">
        <property type="entry name" value="Cyclin-Q_second_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="72"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ku" evidence="9">
        <location>
            <begin position="519"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="698" mass="78482" checksum="9BBE3075DDF83727" modified="2021-09-29" version="1" fragment="single">ACEGSLGDSSARPRAQPGPATVPVRRRAIPIIEQTFKKTMKDVIDVMALQSSRRERRLPDYRSAPSHSLATNFIFECGIKLGLQPATVATAAIFYHKFFKEADKNDYDCYVICTACLCAAGKSRDEPVRLRDAVNVAHNSINRGAGPLELGDEYWSWRGAVAQAELLVLRLLGFNLDTPSPHRYLLHYLRTLQEWFPPSQWRSAPIARTAMAFLQDFHHSPSILDYRAPHVAVACLTLALHVLGVSVPLASTLDDDAAWYSVFTKDLQKEKNWEIMEKIMQVYNPCANNIIKMSSDDETEQVSSVKGIPATLICINIYGPCKEYSAQVAHTATCRLIRQYLRNARSQLVGVCVYGTLSTRNVIMLSRLDIPPVATDIKPSLKRVADLVDSNIQINLINISKSDYEADPYYTNFLKQATNEDEVDIPKPISNHSEVEQFMYLESHRNLAIARLSFEIGEDFAIGVGVYNLLKSYTQMKKSDLDSDTNAVLTSVNKTMKVKAANIDEDMDVDEQDRTESRPVPVLQSELLYSLRYGDENVEFTAEEKKMLGNPFGPPTLKLLGFKPASVMKKEKWYLKSSYFLFPSESIIEGSVVAFKALHQACMEMNTVAICVLCTRVNARPFIVALSPTSRPFGLNVDLGFDVICIPFMENERLENNAIENYTVAQLKEILRYKEIPHLPALTGLRKVELVDLVYKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEM8</accession>
    <name>A0A835LEM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51446">
        <property type="entry name" value="PACIFASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Pacifastin" evidence="2">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="527" mass="59938" checksum="1883739F7E4120E1" modified="2021-09-29" version="1">MSYKEPDTSSYFKIKEFGNIFKDVFHIFRARGDTQEGDYDGQTVVVDPTHRSGQDPYLRVNNDKIDTKKTKHCNVGERYRLGACNYCYCNELGIRICTRHSCDNHGTELPDSEYTPKEYETECKIGVRFRLDKCNYCYCNAHRQLICTKNKCPSSYDQAPYLRSPFEEDCEEGHVLADSCVICTCTANKTYVCIPEKTEDCDMPIHTNILPQVRANDDSCIDGSQRQKDACNYCICINGIEMCTQKPCLDTVPNVSVMIEKDCVDGEVHSTYDGCNVCVCMNGKIACTNKGCLQVLRRGLKPLDLVRSLLQSLYSQSQIPPQMLEPGCNKEMLYLPEDYDPECPNVCLCDGNELFCTHRQCDKTDSKIHEPKRLESKGVKQNTHKADVTFCKPFTFFSPDGNRFCRNCFCLHNGLALCLLNLCKEDTPHKTINTKPGKMLRKYCREKDKFQMGFPPYCAQCKCLSNQWDCSVKGESCSGDVKCPFGTLIQNPRQRCSICLCGGYKPGSHNLCFTEERCVETLNKHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G220</accession>
    <name>A0A835G220_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000605">
        <property type="protein sequence ID" value="KAF9406352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G220"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033111596" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="540" mass="61101" checksum="C6154C7236C1C2D7" modified="2021-09-29" version="1">MWKYLVLLVYVSVRSVFAEEQWLLVNITQGPVRGRLEDGVYSFYNIPYASVPTGTDRFKAPLPPPVWLTPFNAVDRKIVCPQNWRDSKEVNIHENCLVANVFVPDTEETNLPVLVNVHGGGFILGYGQQSEFKDIVRSRKMIVLTFNYRLGVHGFLCLGTEGAPGNAGLKDQLAFLRWVQSNIASFGGNPDDVTLAGCSAGSGSIDFLTLSSLTKGLYTKTIQESGVSIAGVGAQVDPIEYAKSYARFLNFHNVDDLNSLEEFYRTAPLELLVSGVDEMINTKNVNILFGPCVERDIGQERVVTDAPMNIIKQGNYTQVPRIYGFTNMDGAFRLPEFDTWKNDMNERFSDFLPAELYFETEDIREQVAQEIKQFYFGSSPVSEENILAYIAYLTDVLFAVPTLKSISTRIETLGDTIYLFEYSFVDEQTPSFPHTDVRGANHCFQEVAVTDEDVTDRTDEYKQMKEIMRDYWTNFMLTGSPSNTNSPLPYWPPTNAQRTPHMSLGRHIELGTDIIKDRVEFWDTIYDKYYRGPAIFSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3Y6</accession>
    <name>A0A835G3Y6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000417">
        <property type="protein sequence ID" value="KAF9407984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="313"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="2352"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="5">
        <location>
            <begin position="3206"/>
            <end position="3485"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="3">
        <location>
            <begin position="3206"/>
            <end position="3325"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="3">
        <location>
            <begin position="3339"/>
            <end position="3485"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="3">
        <location>
            <position position="3237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="3">
        <location>
            <position position="3388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="4629" mass="518087" checksum="38EB7DB943BDB5E2" modified="2021-09-29" version="1">[encoded data, 4629 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3Y7</accession>
    <name>A0A835G3Y7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000664">
        <property type="protein sequence ID" value="KAF9405909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3Y7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="32709" checksum="5A875AF45B869647" modified="2021-09-29" version="1">MATTVVVGGVLHSPDGAVGFVEGVRALHDITVAGLLLGLVVTGVAVGYGVVVLVFGRELRRERRGRRLGRGQRGRRQRERGGRRRQGRRGRRLLGQRRLRVGLAGHDGLCFGKRRQQLRSSGQEQLGRQRQRGRRGKPLGPRQQRAGQTGRGARCSGRRQRQRRSSALGRAGDQPGTPPLNHTELQPSSKNCIATVVVGGVLHSPDGAVGFVEGVRSPHNITVAGLLLGLVVTGVAVGYGVVVLVFGVSLVSYDGSGVVSNWGGGSVVGDSGSGVVGDGRGGMVGDCWGSDGYALGWLVMTYNVLGRHGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G423</accession>
    <name>A0A835G423_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000582">
        <property type="protein sequence ID" value="KAF9406503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G423"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="401"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="552" mass="64327" checksum="C239799F0EBEFDF7" modified="2021-09-29" version="1">MLPKKTTLLGRMYRTLRKTAQLSKHHPVTYEYFRSYPAVVAERQRQLLEEEGNVIHPLSLFSLVWMSVMMMVNLMHIVVSSFRLFFILQPIDDPEIHWLDLMMVGLQLVCLIDILIKLNTGYLNKSNFYIVMNKKSIFYKQISLSHYLRRWFIVDLASSLPAVYVVTYLKASNRLQLIAHIMALLRTPKIYEVAIDLKIFLKLFTESYIVHGLVRLSVMFVLSSHWCSCLMYCPAVIVYYWSGEMPTHYNYYMRTGPGKKDLMGYDLTTRFNKAIIIALSAFFGTGFTLFRSTEPDEILIHSVIIVYAAMFMVFTLVYLIKSYLTIFGSSMRYQGLMNQVEEYMKYRQFPPSLKRRVRAFYQYRYQERYFKEESDLDCLSEELRDEIKLHTCRTLVHKVKLFEDVSASVVGTVLGCLRPEVYLSNDLVVRAGDIGDCMYFIATGTVAVYSLKGVEVCHLEDGHHFGEVALLMKDSKRIATVVAVEITQLYRLDAPDFNRFVLSNPTLYDRVEALASRRMHHTVLLDDAFRREREQHNLTEQANDPPNENTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4T3</accession>
    <name>A0A835G4T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="79"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="182"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="299"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="640" mass="67237" checksum="C561AFC35560CFB0" modified="2021-09-29" version="1">MGIMPAARGVKRAASKSSTATASTAAKNKKKRGVEMGFGKPCLVNIVSQTRASLIITIVHCICPAIQWEIPSAPKKRGRVLACGQGDVGQLGLGEDVVETSKFKYVTALGDKIVDVYAGGMHTIALDSSGKVWTFGCNDEGALGRATSGESEEGTPGAVRLPAPAVCIAAGDSHSAALLNTGDVYAWGAFRDSHGSMGLVVRGREGKSCREPVHVDIGETAVAIASGGDHLVILSASGGVYTMGCGEQGQLGRLSQRSASRDARQGFSALLVPSKVTLKAGGARIWAGYHATFVLDNNDKMLAWGLNNYGQLGITGEKRKTAIFSPTECDAFTSQQCTWVRVACGQHHSLALDSAGQVYAIGRCEYGRLGLGDRAGDAEVLEPIPALQNKKVISIAAGTSNSFAVTDSGSVVSWGMGSEGQLGTGACNDAAEPTAAVTPALAERTPLHISAGGQHTVLLVEDPTSQKEASPPPESETSEQKGDSQSAESEEEEPKPAKRPKNEQEGEISSTSSAQPSEVAEEAKLQKVNGDEKKETPMEVDETDTPQQKEEDAETETKSADEQTDTEQTEPENTQTEDSKPETTDTSSQETTDSDTKSQEPEKTDVEMSEERTEVNGTPEVVEPKTVDVIPTANPLTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5H5</accession>
    <name>A0A835G5H5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5H5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="64104" checksum="9580AF7A4CCC1376" modified="2021-09-29" version="1" fragment="single">MASLQCINCNVRMSRIRRHALLDENEELINTIRIWIYPRDITPADYVCHACWQLASHAHSSNDISRRRVGYQHLRSEDEACVPCWLRARRARIAPPVDDLQTPSPDQVDVELSILMCAVCGQSLTTTTSDGEWNTDNIARLLEHQQMSAMNEVCGVCWDHARDLNVPFPEERQERPQRIVLPNIRRAAETPQHCVFQECTEPQRNAVPEETRREVLIRFQYYIPRGAHICSMHRQEANYENLYTAEYSLNTFTSVHIEEIIFILMEGLQNISYENIQNYPDHQVQYFVGVTKAQHQQILDRTPRLRNMCRGSFALTALLCKLRTGDSGDRLSCLFQVPRRTLETLMSVARDILLTDYVPQYLGFSHIRREQLSTLDANRSRCVTINRWVVEAVNGRFKRDFKIFRHEYFNRGCRHLMADFKIAAALLNAFTPPFAENIHAEQFVSIIYERLFLSNTVAALVMKHNLNRRGSWFVPIDATTVSFPRLSIEELILFACGVYQIRQARSYVGEHFRFHGIYTLEVARDRVDGLEGINPMLLRAKIKSRHSSARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5L1</accession>
    <name>A0A835G5L1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_013472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000654">
        <property type="protein sequence ID" value="KAF9405995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5L1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="12">
        <location>
            <begin position="279"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9405995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="626" mass="69019" checksum="F507A0FE67C7A714" modified="2021-09-29" version="1">MAVNGDSLKKMNNIDLNKLGADLHVEFNRGRRLSKANDAGERRVLVIYTGGTIGMVKTDDGLSPGKNMFKPSIRRYPQLHDENYHQKIMKASPADKSLENFFALPKTDDVTWRILYEIKEYDPLLDSSDMTEADWIKIAKDIQADYEQYDGFVVLHGTDTLSYTASALSFMFENLGKAVVLTGSQIPIFEPRSDGVDNFVSSLIIAGGYNIPEVTIFFYGKLLRGNRTRKISVNNLFAFDSPNAVPIVKVGLEMEVNKSAIFKPTVIEKFQVHAKMSKHVAHLRLFPSISTEAVKSACQHPIQGLVMETYGAGNVPATRHDILEVIEKAVKRGVIIVNITQCATGAVAALYKTGQAIAKAGVISGYDMTPEAALTKLSYVLTKTELSYQQKVDMMCLNIRGELTNLSSMSIEDQTLKEALGISLNIQSPKKLAEVVANVFSSLLLYGIKKGDEGIVRKLLDMGADVNAEDSEGKTPLHEAILTGNHEMVECLLMNGANVHFKTRTGECPLITAVLREDPQIINLLLKCGAHLASADIYPVSEIMTTAIRTGSISKLESLRLAGAKFDIVDELRQTPLHKAVLCNRPEAAEFLLRQGVDKEAKDVLGHSPADYVLKLNRRSLVTYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6K8</accession>
    <name>A0A835G6K8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000539">
        <property type="protein sequence ID" value="KAF9406859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6K8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="4"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9406859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="944" mass="107325" checksum="660B189947735277" modified="2021-09-29" version="1">MDIPVQIAVRLKPPNLEDSSQCIFSNPVTQIVITESGQTFHVNRALPVDCTQANLFNSFMIPQINCFLDGCDTSVVVFGQANTGKTYTLFGPGFECIHSECDQGIVPRFLSEIFHKLNQMPEREFILHITWMQVVNNNIFDVLGAGLVRCCNVEEAFQYLQLGWRQRCQGNNHTVFTVSVEQKWVSTNGVLNHRMSTASFCDLAAYPEPGMFALENIIKELLAGNPPKQINYDQCILTAMLRDSFGGRAFTWVIGCISAEPEDYQDTLKTLNLCLCCRGIKNFVTVNLFADNNTPVYTEKSVLPHGDNNFNLQFATTQWIKLVSNAEGLFNKILQSKSLSEADINQVSEWLFLKAECDECLNGDGGVDNKDANIKQGLPRIAEDTEPSEPSESDVDSDSEEDTHSDTVFQDKLEKFMEYFREKNDQLFADRCEEYLNHIDSDDITISELSGSQSLPVMTSQSNSGRRRTIQPGESLSGAELELLRKVAAKAISPESQKIIIESHKKDVDPEPKLIERELLKMIDTPKTEEICKKYKMTKEKYTQKQILARKLSKEIGSSQTQLKELINLCIAKERLISDLSKSMSHTQNKHYSDKIESSLIDQDTMREIKRHETNLKTYKKQIDQIKRQIKKDEKRKNTLDVELVKDKLKLDELSDTSVDIKDRKTHSLKHFTHRITQLDSILKEKTNDLETLEMSKEKELLLRKEIKNLRKTRECLHEQRCSLGHKRKIYKSLSDSEERKLLECEEAIEAIDTAIEYKNNLICGKSPSASLSDSQDNKDSRSRGEQMLMARLDKLSHDEMKTLLYRYFQKVVDLRGACAALEAGVASASEEAAVWRARAAAAWRHAQRLRPHAHSRHFQSIHRCLDGGNAERALSLGITTDSETSDDAMRLVDRMKQQLARCPAPPVIPSQNLRQLMPATNLPVAKVTKEKNKLIIVQQNKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7L2</accession>
    <name>A0A835G7L2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000416">
        <property type="protein sequence ID" value="KAF9408003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7L2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF169">
        <property type="entry name" value="PROTEIN ATONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="156" mass="17867" checksum="6EA1B17D39B3DD9D" modified="2021-09-29" version="1">MTAETYGHRLIYEKDMFASDVMLEYSTEECYLSWPRSPDSGRSSLEPTPSIDGSINQDSSHIAYRGLSREVMEDSAEDNEVLESGKRRGRATSAAVLRRRRLAANARERRRMQNLNKAFDRLRGHLPSLGADRQLSKYETLQMAQTYISALYELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G826</accession>
    <name>A0A835G826_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G826"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF150">
        <property type="entry name" value="FI01825P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032970269" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="62"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="328" mass="35435" checksum="99481022BF4BEA1D" modified="2021-09-29" version="1">MMTLAQFVFLLVGASVVLALPNGVFIPRTSLRYQHIQDDVGRLHLIDFWAPDTDFSARYNPDTQNQYHLFTRKNPTVSQPLVRGLEDLVKSSNFDASLRPAILIHGWGDDARGSFNAAVLAAFLAAEDMNVIVVDWSAGNSGLNLVRAVQNTILSGASVARFILWLNSVTGANLSQYHVVGYSLGGHQAGAVGRNLGGMVAYITALDPARPLFENNPDKFASSDAVYTEVIHTNGGGLGYLEPLGDVDFYPNGGVKMAGCLTSLVFHYFAESIRGGVFTGSKCKSYQHAVNGDCPSEDTLLMGGVKPKTGYSGVYYLQTNSWPPYSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8S7</accession>
    <name>A0A835G8S7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8S7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="18027" checksum="4D9A39EF27965E27" modified="2021-09-29" version="1">MKEIAWIIHIRRLIAVTAFRRPTAKMKSVLLIALLAVTYVCATVDLPEAEFRRPEVNASNLRLILGSKSGGEDRLLSRTYHYVERSHRIAHRQEILIRLVDYARITRVEGWPGYPDLELTVLEGGFGQNFVKLGYVTEENMDFQYTIDVYGVLVCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G924</accession>
    <name>A0A835G924_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_014400</name>
        <name evidence="3" type="ORF">HW555_011167</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000315">
        <property type="protein sequence ID" value="KAF9409492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000061">
        <property type="protein sequence ID" value="KAH9644912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G924"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032452309" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9644912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="161" mass="17391" checksum="A7C8C74EC420ED56" modified="2021-09-29" version="1">MISLIPICLVFLLTSRLKCLFCGGGTGACPGNRGGAADCFMSFLAILIIFFIFRATGVLDKIFYSLGYTKAAGSAGGKAVLVDARFIPTPGQVTECSRNDTEGPAKELREFIEKYGGLKIPGHYLASATQTTPWTDTDTGTTYTVLETRNNNYTTLLYYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G960</accession>
    <name>A0A835G960_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G960"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="289"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="530" mass="59404" checksum="7AAACB4AD389A802" modified="2021-09-29" version="1">MRMGHIHSLHIPMVVIIIQYNINTFSFVHRQTKPQTTTEVKQKSQWIDMTHDTDVNHLKKTPELTREERENVEVLYNNKYVPLSEFEQKKNTGEFETEELGLFNDNSIERFKRGAKNPTTVRPPEDSRTSPEGVTSRKERDVTMPVSDFVSVRGDPSIVNIEGLRIENSDKEPRIIEEGIPSVLADSRVTLRLFGDGLTSRTVIAFTHETQIGGQPCKFLLKGEYMVKEGTLRPRTALFDIVAPAPITDSKLYICAKNLRAGVDDPFQDEEKYLHQGTEVYKMIASHNTLLPLWVSLTLILTCLTFSALFSGLNLGLMSLDRTELKIISNTGTEQERKYARAIMPVRDHGNYLLCSILLGNVAVNSTFTILLDELTSGLFAVIFSTLSIVLLGEITPQAICSRHGLMIGAKSIMITKAVMALTAPLAFPVSKLLDYFLGEEIGSVYNRERLKELVKVTTDVNDLDKDEVNIISGALELRKKTVSDVMTKLEDVFMLPISSVLDFETMSEIVKSGEDDDEDTTSSSESESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9L0</accession>
    <name>A0A835G9L0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_017259</name>
        <name evidence="13" type="ORF">HW555_010896</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000293">
        <property type="protein sequence ID" value="KAF9409863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000134">
        <property type="protein sequence ID" value="KAH9643478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9L0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF134">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="76"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9409863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9643478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="30394" checksum="6F242D308B9F9789" modified="2021-09-29" version="1">MKLEIVLEPDNFTFDIADLSTSMYLTDIYVNKTLEVNETTNDLVYSNQFEDDPFIVFLVILKCLIMLFIILAAIFGNLLVIVSVMRHRKLRVITNYFVVSLALADMLVAIWAMCFNFSVEITNGEWLFGYFMCDVWNSLDVYFSSASILHLCCISVDRYYAIVQPLDYPLIMTTAKLGIMLAVVWCSPALVSFLPIFMGWYTTEDHLNFRKRFPNVCSFTVNKVYAVVSSSVSFWIPGVIMLYMYYRIYLEAERQERMLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9M8</accession>
    <name>A0A835G9M8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_010570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000268">
        <property type="protein sequence ID" value="KAF9410322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9M8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="740" mass="84534" checksum="5A419D76896B72EB" modified="2021-09-29" version="1">MENLTVLSFRKFEDIKRLARHFQNVVNHPLTQQNKVLHSYLRNLDETHKNIYLQKRDYVEVEYIFTTEKKSSLQRQRFNSLPVSEVPELLKAELFTSDDAKQVHICTDCNIEIELNDEEPLMESLQRHFNSDAHLPKLRRESIDVAEPIILPNMSRRLSAMAELPLPKIKELTITKPVEKLEKNFSSKLSTSLMKILPDASEASVDAALKFYQELYDKLCSDVSNIDFSTQTSSVAPIIMSIKDNVYQNFAGDANKNIDNDENDQAAEKPKNQVKKYRYYGPIEASIVKLLVNHKLLSLIDDRTGKLAFFCIACEYYTLRFHYDSVLNHVFSETHVHNLSCILQSDKSISFSMTEPTIEKIKEMNEKFLLSHDIVFTPIGLNCRLCATPIESVEASILHILDEKHLARLSDELYLRMKEADPDGAIPEEWGPKDLNWSKYLASVGKPHNNRDHVVIENFIKPSGKIGNYCTCCDMTLKGPRQVLFNHIRQKKHLRNAAPRKLSMLYKNHCRPSEYYASFGNFYICTICPEFVATPSISAMVEHFESASHFDTIAKLIRSALYNQPDMQILSANKITADLKCEVCKTSFHDKSEAVKHILSSIDHETAVAEAKISFNKGDIISVYMKGNHILHSEGATFTCIDCKGVFNSIRSLLTHLVYAGHFKEKPAIEGVFRFYLELKHNINMLARNKYVYYQFGSLKCGVCDADLEEGETAKKHVVSTRHRENMGASYVSIDTSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9N1</accession>
    <name>A0A835G9N1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000254">
        <property type="protein sequence ID" value="KAF9410636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9N1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="390" mass="43396" checksum="C9FCE08FB4D1EDB3" modified="2021-09-29" version="1">MSTSTIRKQRCQKLITMSTDKCSDTRSQTNSMSTEIEINEPTNYQGTVINKKPRSPLRNSRSQSRESRYPNNTTSLHRRVSTSPCMEVEQLCRKSRSPYMKSRSPNKETNSPCKETRSPRRQSRSSSSSSSSSSSSGTTNSTSSSSVCSSSASTGLSAPPSSYDNADQCKISSTNKSVKEENAGQVKKLVLTEEKCESYTEPRPKLSNDAEFESDEIIENTPPRIIKKSTTNKDKVARTPGHAITKNLVSYSDSSSEDSDDNTQQPKNRNKTDLSNKEPNFVASGSTPLLEVANRTRPQVDFNSTPKYAISPIYTDESDVDLSDDDPTYVHTTNYGNKQKNFFISSPSRSLSSSCDSDVSNKEVKRGRKRIRDSSKWKQNKAKRLRNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9U4</accession>
    <name>A0A835G9U4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000281">
        <property type="protein sequence ID" value="KAF9410035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9U4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="323" mass="36675" checksum="F6B1F88443A07EDB" modified="2021-09-29" version="1">MTAVVAMSTTTSPKTSLAKLVLYPKPKPFKVMVLGQSGVGKSALVVRFITRRFIGEYDPNLEKIYAFQTVIDNEMVYFEILDSAGESHESEYANLESNIRWAEAFILMYSVTDKCSFDECHRLKFLINYNKRRRRLASSMRDSAIETPVVMVGNKVDQVGDRMVTTEEGQRRSKEIGCVCFHEISVRESIDQVWGVFRDARRFWRVSSKWSKRDGDRHPPALGRPLARASSDTTPDTNAAPPFCRRWTEMELDEEDEVCVGRSDSTSSSGRSECGDEFRARASTDSRLPPRPARPRHPLPTRPFPAPVRRMSVAMRGNNASTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA27</accession>
    <name>A0A835GA27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_012750</name>
        <name evidence="6" type="ORF">HW555_010117</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000107">
        <property type="protein sequence ID" value="KAH9643875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA27"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF4">
        <property type="entry name" value="FI09323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9643875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="19128" checksum="907E817DC9513D9B" modified="2021-09-29" version="1">MENYSKGKNVEEELERSKIPIKDLPDNFLWMQVKGGSKMANLLSHAAGILEDKAATAVVWTGAGVAISKAISCAEILKRQFSIEHQLTKLSYKTVEEYWEPKIDGLETLVVKRQIPIIHILLSVNAIPDTNQIGYQSLNGKKFWQKEQSSNSKQNQSHKPKKPFKHKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAN4</accession>
    <name>A0A835GAN4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000208">
        <property type="protein sequence ID" value="KAF9411921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAN4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116018" checksum="C81FC2BDD163E8F0" modified="2021-09-29" version="1">MMVYIKIKMAALRSVLFGIFLMFCSCEAYKILAIFPVPSTSHGILGDNMIKHLLNAGHEVTYITPFINKKKYDHPNLKIVDVSTNAQYFDESLTDIKLIMDGVLDYKDPVLMSQLTIMMASHTLGNPNVQKFLKDPNQQFDVIIGEYMFSDLYSSFQAVFQCPLIWFSTIQPHWAILNMVHGPLNPSYNSDYIIGNVAPFTFKERVYELWVQLKGFVNLGAEEKVYLEHIAPIVKAQGKPIPNYEELKYNASLVLGNSQVVFGNAVPLPPNYKHIGGYHIDEDVKPLPEDLQKLMDNAKNGIIYFSLGSNIRSKDLPDSMKDGLLEMFGKLKQTVIWKFEKSLDNTPKNVHIVQWAPQQSMLAHPNLVLFITHGGLLSVTEAVYFGKPLVAIPVFADQFLNANSFQKMGAAVKVDLTYNLHKDLEVALNKVLPELPKYTARMKEISVAYHDRPMKPKEALNFWVEHVVRTRGATHLRSVALQVPLYQQAYLDLLAVLLAAAVAILLVVRRILSLFTLCSCDAYKILAVFPMPSPSHGILGDNMVKHLLNAGHEVTYITPFASKQKSNPKLHIVDVTDHHNFFNTDLLDITQILAGSMNFKDPNFVFSMMMNIAAMTLEHRNVQKLMKDPQQKFDVIIGEYMFADLYSTFPAVFQCPYIWFSTIEPHWMIVNLVHGPMNPAYNGDYMHANIPPFSFMQRVQELWILLTGLYRHNNEYYKREEEVYQKHIVPILKEQGKPVPDYKVLKYNASLLLGNSQVAIGNAVPLPPSYKHIGGYHIEDEVKPLPEDLKKIMDNAKNGVIYFSLGSNLKSKNLPDELKKGLLEVFGGLKQTVLWKFEENLPNQPKNVHIVQWAPQQSLLAHPNLALFVTHGGLLSLTEAVHFGVPVIAIPVFADQFLNANQAQHKGIGEKVDLTYNLHKDLKVALDKVLADLPRYTARMKELSTAYHDSPMKPKEALNFWVEHVVRTRGAPHLRSVALQVPLYQQAYLDLLVVLLAAAVAILLLVKKILCYFKSQKSIKQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAV7</accession>
    <name>A0A835GAV7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_010552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000267">
        <property type="protein sequence ID" value="KAF9410335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="83"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9410335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="542" mass="58107" checksum="0F0CA8955CAFE2DA" modified="2021-09-29" version="1">MFGSGFGSNAFTVMALPVLGPQIVTGAILARTVTSVTCAAGQPTSYGSNFRYKRPEGNGTMADMGVSQAELVEPRGDNGRKLPQYLAALAATLGALAAGSMLGWSAPVMVKLTDPNSTDYDFPVTKGQGDWISSVINLGAAFICFPIGLVMDAIGRKKTMLLLVLPFTLGWLLITFGNSVGMLIAGRLITGVAGGAFCVTAPAYTSEIAQDSIRGTLGSYFQLMITIGILFAYVVGGYASVFVFNILCTCIPIIFGIVFFFMPESPNYLVVKGKNDEAREALIRLRGSAYDVDYELNNLKSRAEENERNKVSYISALKKKTALKALLICYALMVFQQLSGINAVIFNTSQIFSDAGATIPPTISTIIIGVIQVIATFISSLVVDKLGRRILLLLSALVMCVCSTALGVYFFLQQTHGSEADIVQAITWLPLVSLSLFIIAFSLGFGPIPWMMAGDLCQIDIKAFVGSTAGTLNWLLSFTVTSTFNSLNAAIGSGQVFWMFAGIMLIGFVFIFFVIPETKGKSVDEIQVLLGGEPQQRAEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAZ5</accession>
    <name>A0A835GAZ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000215">
        <property type="protein sequence ID" value="KAF9411720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAZ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12286">
        <property type="entry name" value="RRM_Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1180:FF:000002">
        <property type="entry name" value="LEM domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034394">
        <property type="entry name" value="Man1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="9">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="782" mass="87358" checksum="03E9211F08B8A324" modified="2021-09-29" version="1">MADQVDSMSDAELRTKLAEHGFPIMPITASTRKLLVKKLKLVLDNKTKPRASVDNKADTRRSLARYSSGEESDLDTTANAKEKRGRRATTGGAMLPPAANKARRPPPKKGSPAKRDSDKGSESDEEKPVRTHEEVETVTTRTIKRTYAANDADDYETGSDSDVDADKKTSSPFRSNSRSSDYISSTLPSVDVNVSPPKTSEFSRASIIPTNYSSSYSSSMTSSDNLNSIRSRLGLTSSLADRPSIIPTTNYSNYSTSTYQPSTSTIDEVESPYLSNFTRRLSALKSDPPKPATSYLDRDTTNGSTVLPRRSYITGVNRSDVVDYKSATDKKFLKNNLVSLALVVLVALFFFCLFFMYIVKKNDITSVVDDQNSIIPICQLNIPGNRPGINCVPKEQVSYAKNLLKVIHPELTSRIASYKCGQPGSLPYLTEREIIDMASAKAVTPDVSSQCRTDLNNLQVLLINNPRWGLNVVQLKNLYTNDVEYSPIASTDLIVQLRTKGTVAITLSDPSTPLSCLFVNTLYSAGSSLIVIALLTLLALGLQRAYKYYVMYQKRKSEEIYSMVEQIIDVISQETEDSGEPYISVDHVRDTLISPQNREKMASVWDAAVKFIQRNESRVRMEVQSVDGEDCRVWRWISAHSSPKRSASWQGQAFETQEGSVNNLVVSPTPCLKIRHMFDKNDDNPLLRVKIQDAILEKCDTHCNILHIDIDRSSCCVYVKCASPGDAGVVYRSLHGWWYEGRLITVKYLRLERYMQRFPTSPTSGPYLTLTRHSRRGLWPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB45</accession>
    <name>A0A835GB45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="60542" checksum="EFAC16B7AB71BD49" modified="2021-09-29" version="1">MLRIIQNASGRLKIPTVNSRRFYAKEVRFGPDVRALMLQGVDILADAVAVTMGPKGRNVILDQGMGPPKITKDGVTVAKGIELKDKFQNIGAKLVQNVAHKTNEEAGDGTTTATVLARAIAREGFENISRGANPIEIRKGVILAVEAVKAKLKEMSVPVNTAQEIEQVATISANGDKSIGKLIAAAMNRVGKNGVITVKDGKTLNDELEVIEGMKFDRGFISPYFINSNKGPRVEYNDAYILYSEKKIFTAAQLVPALEIANAKKKPLVIIAEDYDGEPLSVLVVNKLKIGLPVVAVKAPGYGEYRKSALHDMAAATGGAVFEDDLNLIRLEDCQPESLGQAGEVIITKDSTLLLKGKGDPAEVKQRIAEIKNDLETTTSNFDRERLIDRLGRLQAGVAVLMIGGCSEVEVNEKKDRVNDALNATRAAIEEGIVPGGGAALLRCIPTLDKLKPANSDQEIGVSIVKKALRTPCITIASNAGYNGAVVVSKVEEMSSEYGYDALNNEYVNMIERGIIDPTKVVRRALTDASGVASLLTTAEAVICELPKQTPPIPDYTPLGEGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBH5</accession>
    <name>A0A835GBH5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="12604" checksum="B0CA627405A4A30B" modified="2021-09-29" version="1">MRLQVPNWCNIINKILKGAVEEKYISKMETLSIVETLDNLWLKPLNSYNSATTDLSETRQKMAECQKQWKKLRDCYKKALRLRQYKSGSARKNEKPIKFEKELEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC14</accession>
    <name>A0A835GC14_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC14"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="602" mass="66653" checksum="C25BC7A62A699716" modified="2021-09-29" version="1">MRGAQTSTDTQGPIEDAQLITFSDCIIEFEVSEEIEDVEKIDCSIKNPSLPVLPLHKDIESKPKLSQVAKLAEEFRAFRDLVIGMLGLLRRQIGECSWQLDDIETRSRRKALIIQGITEANSEDCTNVALGVINTKFGLNFTKESIKVCYRLGQANTDHHRPFLVRFTSMDAMMSVWRAKTGLRGSKIAVKEFLTKTRVFGTARQHFGMQSCWTQEGSIFIKAPDGIRHKLTSLDELNSLLSKYPTAQGSSLVVTLQLSFASTCGVANSINRICANILSVPAGNCGNLGRQLKNKHPTVPLVTDRQPTQQTPETLQKTLASTSTATESGTSGTSGTEDEPGAGALGPCPRLILHCGLYEERLKVNGDADIPEDVKTAYEDHKTKASKAIQKYQEDASVENSSSILGFDISQPRASIEVKENAFVDSPDEHASPFDYFYMFETAKKHLPDEKAFKQKPKGHFADVSCDKNRLAWVNTKQRQREALMKERQDSYWRRPSISDAVVDPDVSMVAPALIVGIDNAIDSDLVEDSSQSQIPDAVEIEEHYVIEDVSQTSVISHDQATEDPIVLPDSPIPFTSQMSQPFLTTIPSARKHLHVLTLEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC44</accession>
    <name>A0A835GC44_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
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        <property type="entry name" value="SNARE"/>
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    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="321" mass="37200" checksum="49A24EF8FFE0BB50" modified="2021-09-29" version="1" fragment="single">RPNTGQHNDSERVRLMRSNSHDLESGLEMRSDSHAPPPWTDALEEAHYVITRLRTKLSELQSRHEKQIRRPSLDDTTEQQHIQRLTAEIGRHFTHAHTHLTAIKAQIRHGNPTEQKLATNVVLALVTILQDLSVTFRTAQSTYLKSLTSREERSNAYFELPNFEELSLDDNELLPGLSNNQTDLLFSLPSTSGTQKFDDNDDFSRPALNQKQLLLMQEENTRVVAEREEEVNKIVRSIVDLNDIFKDLAHMVHEQGTVLDRIDYNIEQTQVQVHEGYKQLQKAERYQRSNRKMHCILILGVTIIVLVIPPHYCQDWYLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCI1</accession>
    <name>A0A835GCI1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UBR4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000194">
        <property type="protein sequence ID" value="KAF9412274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19680">
        <property type="entry name" value="UBR-box_UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="E3_Ub_ligase_UBR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045841">
        <property type="entry name" value="E3_UBR4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056530">
        <property type="entry name" value="UBR4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047509">
        <property type="entry name" value="UBR4-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13764">
        <property type="entry name" value="E3_UbLigase_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19423">
        <property type="entry name" value="E3_UBR4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24079">
        <property type="entry name" value="UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52043">
        <property type="entry name" value="UBR4_E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="9">
        <location>
            <begin position="1737"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="6">
        <location>
            <begin position="1737"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1450"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1492"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1815"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2471"/>
            <end position="2502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2742"/>
            <end position="2784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2835"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3346"/>
            <end position="3377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4028"/>
            <end position="4073"/>
        </location>
    </feature>
    <feature type="region of interest" description="UBR4 E3 catalytic module" evidence="7">
        <location>
            <begin position="4738"/>
            <end position="5207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1453"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1492"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1526"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1834"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2751"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="2839"/>
            <end position="2852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2870"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="4028"/>
            <end position="4041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="4058"/>
            <end position="4073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="5208" mass="570207" checksum="83638EF773591117" modified="2021-09-29" version="1">[encoded data, 5208 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDH3</accession>
    <name>A0A835GDH3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000182">
        <property type="protein sequence ID" value="KAF9412637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDH3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF17">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="238" mass="27313" checksum="E0D14D50ED0575CC" modified="2021-09-29" version="1">MVNDAQVQSPPNLDVRGDERTNEKCDVNRSVKVLEYKVYNVVPSISAITGISPQRYVWRICIAFHLGPRLLIGSLYYNYHKERTAHITEEKARTTATKLGQACYWLNFIELFALTGVTYISNRENYFVHEKIFIVFMVAALLHMLCRARVGCIASDVIEPVRTNKLVWTLFYVAIASTVGLIIFFLRHRLLCRPLAFTWFSVCEYILATANMAFHAIVVRDLPQHELQVVCPTHSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDI5</accession>
    <name>A0A835GDI5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21895" checksum="AE41904E9E462FA9" modified="2021-09-29" version="1">MSAGIPELNVPGIEPLSLGQIALARGPQGAKLTAVVNDVKVRGPSNFIIQELKSDLDKNRFDFKLLLPKLDFAGKYKMDIQVLLLRLQGRGNITGTFRDYACNVTMRGHKQKIGEDEHLQFDPFKVKLRVGQSSIYLTNLFDGDPVLGPATNRVINENSQVFLQEISPVLEKSLADLFTEMANKITSKFTYKELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDW3</accession>
    <name>A0A835GDW3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="329" mass="37788" checksum="2C70461191874E4F" modified="2021-09-29" version="1">MTTEKVIGDVAEANDSVPALLPQNHRFLEPEKAVKTLTDMAIWEKSEAYMEYTGFIATLNEAIKAKPLTVDCKISDNVKKLIKMLDLIDNLIDEFPPIEQPQRFGNVAFRSWLSKLKLNSTLYLQDALHQSIHLAISEVKVYLEESFGNATRIDYGTGHEMAFAMFLCCLYKIGHLVAEDNVAVVFLVFNKYLSIARRLQKTYRMEPAGSHGVWSLDDYQFIPFIWGSSQLIDQPRIYPPAKFLEDDIIEKYHNEYMFISCIKHIKEVKKGPFAEHSNQLWSISAVGSWTKINQGLIKMYKKEVLAKFPVIQHVLFGSLLPIRRFPLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE50</accession>
    <name>A0A835GE50_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE50"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="323" mass="36240" checksum="3FD768C1EA64069B" modified="2021-09-29" version="1">MNILYTSQKLQELFCDDHLPVHANASGDGDGVPGRCCRLCGGDTNLRYFGDTYVWEGVEERYDKLLFDCFGVKMKEWAFVASSSATTLKSISNCTKTVAKTSVKQEKDQQQQIKPKCDVSKRREVKKRLFANDVKTKRINIPCDVCKQRYPMLMSSDATKSFVCSRCKKNGETKGGALCRRCNIMMPSNMLKEHLDLHAKAELRGKVRLQQAKKSTVSSVNSSTKQRPQKFQCTRCPKKYAMAKNLVLHVRNAHGDSLDTLGPGNKNSLLSSVCGQNMVTRDKLESPLTHSSPHQCNECLLIFKNRRALVAHSTSHHLKSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE67</accession>
    <name>A0A835GE67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE67"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30620" checksum="130CC9AB290355C5" modified="2021-09-29" version="1">MVVGAFPIAKLGALLIKQISKPIANACKERAKHNPFFRTYVCMPPAQFYNWCEVKAKMWILNLGRPVNIPVLSQEMAIELGANLLGETLIFTIGATILLLEYNRQSNKEAAKEAKKEQEMKHISDTITDLYFTVQRQQTQLREMERIIYSISGEKPTVPPPVLKEPPSIVPPPPPTSEAPKPDSPKNVNNNQDHNKQSIITATPYPNNGLILQSLNYIQMDAFSSLFPNNNTKVVIEEEQTAIEEKAFIPKREPAILSSALHNIENNFRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF56</accession>
    <name>A0A835GF56_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF56"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="270" mass="30439" checksum="AAD59002F26D5EE8" modified="2021-09-29" version="1">MIYRHTGLVDANSAPVEEPAKNVTHGKCKPELCDLICRKLKYDRGECLENKCKCFKNEGLVQMNSAPVLEPAKNNTHGKCRQGLCDLICRKLKYHRGECVDNQCKCYKDGVERDDNDTPITQFSEDLKKVVCTKRVCNRMCRSLEYEGGNCKNGKCWCYGPPKKSARSVLENSTEKEKVISLDAATEKVSQIKSDEEKEESKEDTYGKAPPMYKAAGEEEAKLNQDNNTTEKGKLMSRAHQGTCTKKACKKKCEFFGGPSFCWIDICICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF72</accession>
    <name>A0A835GF72_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9414020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF72"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="223" mass="25905" checksum="16C1599D523A77BD" modified="2021-09-29" version="1">MTLLCHHGSTESEILPVIHSPGLYFDPTTNIFFYNDFWKIVTHVDVNSIEPHLNEIDKLIVKSSLLCSKIEPEEYSNCRDIFNSIEVLLETNYVKAHSLSHIISKDTANRFKRALEFGGEILKFFFGTLDAEDARNYDAAIDACEKNDNEIFRLMKDNIHIVKSSINSFNSTITKLNQNEWPYVRCIPFIDLQDHSSRDTSFVNSRFEVFRKPLTFPRFFPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGM3</accession>
    <name>A0A835GGM3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CYFIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1182" mass="135814" checksum="CA576E2799B2F87A" modified="2021-09-29" version="1">MSVSEKVSLSDALSNVDVLDELTLPDEQPCIEAAPCSILYQANFDTNFEDRNGFVTGIAKYIEEATVHANLNELLEEGNDHAVMLYTWRCCSRAIPQPRSNEQPDRVHIYERTVQVLAPEVDKLLQFMYFQRKAIERFCGEVRRLCHAEKRRDFVSEAYLLTLGKFVNMFAVLDELKNMKSSVKNDYSTYRRAAQFLKVMSDSQSLQESQNLSMFLATQNKIRDTVKDALEKINGYEELLADVVNICVHMFETKMYLTPSEKHMLVKVMGFGLFLMDSEVCNINRLDQKKKIRLDRIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHYDSSKWPLSSSPNPPSPQADLMVHLPQIREEHQNYISELARYSNEVTTTFKEAGSDAENKAVTELCLRGLQLLSSWCSVLTELCSWKLLHPTDHASNPRCPPDAEEYERATRYNYTSEEKFAMIEVIAMIKGLQVLMARMETVFADAARRSIYAELQDFVQLKLREPLRKAIKNKKDLIRSIIVSVRETCGDWARGCEPQQDPALRGKKDAEASFTIKVPRRNVGPSSTQLYMVRTQLEALISDKSGGRRTLRKDLDAGTLTQIETFHRLSFYWGYLLNLSDSLQKCCDLSQLWYREFYLEMTMGRKVNKCTVHHQHNEECNDLITMEKRIQFPIEMSMPWILTDHILRTKEPAMMEYVLYPLDLYNDSAQYALTVFRKQFLYDEVEAEVNLCFDQFVYKLSEQVAQRINADMHRALDAAVAKFEAGDITGVVELEGLISVNRLCHKLLSRYLTLDDFDAILRESDHGVLAPYGRITLHVFWELNFDFLPNYCYNAATDRFVKCRGIQFAAGVTREKPQQYGHALLWGSKQLSLAYSAQYAQYVGFVGAQHLHALVRLLGYQGVAVVVSELLDVARGLLHGTIAQFTRALAAAMPRHCKLPRYDYGSNGVLGYYHAQLTDIVQYPDARTELFHAFRELGNIILFCMLLVKKKSRTYFTLRPSRIFFQDPSLQQGQLSREGDLLTRERLCCGLSLFSVVLRRLRTCLSAPQWPAPPAPHHHAPAHTDDTNEFHRLWSALQFLYCIPVGDTQFTVEELFGEGLHWAGCTIIALLGQQRRFEALDFCYHILRVQRVDGKDESVKGIPLKRMVDRIRRFQVLNSQIFGVLARHLAADEERAGVEHVRCFPPPSAPVHQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHK2</accession>
    <name>A0A835GHK2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHK2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF35">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24888" checksum="B19D0EE9A1CD587F" modified="2021-09-29" version="1" fragment="single">EYIVPCSQSDPGLDTCIKNSFNHLRPYLSRGIPELGVPPVEPLFIDRLVMENDAGPVRVTAAFSNITVVGPSNYTITKIRSDLKKLRIDMGLVLPRIEITGRYEVSGQVLLFPVRSQGDFWASFGDVVAIAKIFGKETTRGQCKYMLADRLLVDFKLRTSRFKVKDTVNHGSVIGEAMNQFLNNNAAEIIEEMRPAASASIAKHFQAFVNAAFSKIPIDVWLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHR7</accession>
    <name>A0A835GHR7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_006944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000111">
        <property type="protein sequence ID" value="KAF9415417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHR7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="336"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9415417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="438" mass="48384" checksum="6AC330B7645AB0ED" modified="2021-09-29" version="1">MKLAERLNVLYERNWTRLVHEQLRKFESSIVAAARQSPETQPPELAMDSKWTFSGSLIYCITLITTIGYGNVSPRTAAGRAATVAYAAAGVPLTLACLAGLGASLARLARLAWLRATKRKVPNTWRKDGEPENYLQLHEQQRLLPQPAEHNQYTSFPPRSHRSPGTVKARAGDRGQYSQVFERAPASPRAATLGRVKRSALPDEPHTSTSLQTQTLDRKKTMGSTKCLATVHGPGRGRGRTTMQRPRGAVIEQLIAEECGELQMNRSQDDLDDSEDPDEAICPHDTPSRVPLIWNEESHKMKSCNVPSSSASTSVQHHIHHGIEHCHIPVGIVLFLLLAYICVGAAIFSAWENWSFLDAAYFCFIALATIGFGDFVPTSFLTSKHSTEHTKSEYVQMIACCAYLVFGLILIAMSFSLLQDEVVSRCSQLANSLGLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIF4</accession>
    <name>A0A835GIF4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013295">
        <property type="entry name" value="MAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF97">
        <property type="entry name" value="RE01453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01884">
        <property type="entry name" value="MALPROTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="124" mass="13669" checksum="4F47B746DAD52404" modified="2021-09-29" version="1">MKVLGILCMALASPWYSTWFVFVAVTSFITTLIWSFVYLLSIKEVIKIPINWVLSELISTSIETFMYLIAFIVLFAATAGYYAYGYGSNVAAAVFGIFNTVAYAASSFLLFKEHRGSTATGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIF9</accession>
    <name>A0A835GIF9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="79" mass="9041" checksum="B18CC0F0768AE302" modified="2021-09-29" version="1">MGLTISSVFTKLFGKKQMRILMDLLLQLDWMPLLKEDELRDAVILVFANKQDMPNAMTAAELTNALNLNNLRNRRSCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJM0</accession>
    <name>A0A835GJM0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJM0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="98" mass="10909" checksum="9DC08A06F876718D" modified="2021-09-29" version="1">MAEGRLCEVTPVLGRLRPRPPALGAAHRADGDVRTATSCVRRYSAPSSLRPATTLRTLPLLTLPSNCYLNIVPRRLAFSERPPRIIAKTYIFNTTHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJR2</accession>
    <name>A0A835GJR2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJR2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="381" mass="42062" checksum="94DA5FDD204780B3" modified="2021-09-29" version="1">MLPILMYNNMEGSSNSLNNTPNTSFNQYDDSIILNCVRNRKKVTELPNCPVCSCTIRQGELDSHLSLEVERLQKLSGSGSKRKLSVNSSANLAVPGSSTSQDVLEDEVDVSGCLGSDVYQRVHANRLRRLRARRRSTPPLQQGECPVCNTSLPVSRLQRHALRCLKRTGAELDEDVPDTSSEEGSIDVENDEPSGGGFGAEYQWCGEWRVRATALQDSEARDATCVRRASNDQALVVDGDEDTELYGPPQYSPSRIAPDADLSIDVPTEAQTDSQTEAGESSETERQVATPSNKCNGLVEASAETRIQALKARIKELERKANGGGEMKCLICLEQYTSPTVSIQCWHVYCEVCWLQSLRAKKICPQCNAITTAQHLRRIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK38</accession>
    <name>A0A835GK38_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK38"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="46583" checksum="7032190D867BF6B8" modified="2021-09-29" version="1">MEFIFSHPVSPCGWRPDKCPTFDTPRDRHNLVLSNELSIFRIIISNVITRFAVQDGGEWGEGAQLARCCRRVEFGAIAKLNTQCCTFRTFTMATAKDTSTFFLEADAKDFDSVLKLYPQAIKLKAELKTKKPDELIKLDNWYQNELPKKIKSRGKDAHMIHEELVQLMKWKQARGKFYPQLSYLIKVNTPRAVMAETKKAFRKLPNIESAMAALSNLKGVGTATASAVLAAASPDIAPFMADECVQAIPEMEGSDYTAKEYLNFVTHIRKVCDRLNKEQNGCGNKFSPHMVELALWTHHVISDLQPELLGKEPRTVAPANGGSPLPSDESNLEPPSTNGNGKLGADSVNEDTTTSCTEDSMDAKAASPATPATPASPSDNSDSAFSTPRAKRQMEEASSEENSLGDSSDASALPIAKKLRKATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKM6</accession>
    <name>A0A835GKM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_006486</name>
        <name evidence="13" type="ORF">HW555_004237</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RBM8A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000334">
        <property type="protein sequence ID" value="KAH9639513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKM6"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000157">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="77"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9419152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9639513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="166" mass="18416" checksum="2917853B0BC40293" modified="2021-09-29" version="1">MADVLDIENSEEFEVDEDGEQGIARLKEKARKRKGRGFGSEAGSGGASERGNRGRYDSLAPEGDGNTPGPQRSVEGWILFVSNVHEEAQEEDIQNQFSEFGEIKNIHLNLDRRTGFLKGYALVEYETYKQAASAREALDGADILGQPISVDWCFVKGPTKGHKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKS9</accession>
    <name>A0A835GKS9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11391">
        <property type="entry name" value="bHLH_PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="745" mass="84752" checksum="39040286AC741B37" modified="2021-09-29" version="1">MATEENPREVRNRAEKMRRDRLNQSVADLASMVPPVVAARRKLDKTTVLRLTAHYLRAHQYVFGDSIGKSPQDFSAASIQKVLSMFNGFLITTTYRGIIVVVSQNVNQYLGYNELDLLGQNLHTITHEADRNLLRDQLMPRSQKLGPNGELLIPDEPDAIKKVKRALANEKRQFVIRLKKLGQRSEPNQYITCHVEGSLRKSDRACRTYNRCCQVVRRARARSDNPCSSGNDIVFIGIVRPTSETFINESALESYRMEYRTRHSIDGEIIQCDSRIALVTGYMTHEVSGVNAMNFMHRDDVRWVIIALREMYDQHRLFGESCYRLITKNGQSIYMRTRGCLDVDRDSRAVTSFVCTNTVVDEEEGKQLIKLMKRKFRLLVNSNESPRVDEIEDAQDEIEQNDDSDETVPVEDPRRLEQVILHLVTNLPSPAPPESNQEPNSSPHKNKSPHHLTIIPPNKERIVSAIEKIYNVIKAVPRDSNYEEGSSYAGSSHSTPKYNNTNQIETTVAPPQKAHNMVPYQSCHVSNYVQVPENTFRYPPPTANLTPPQEEYNPPSILNTVASPDLGYFDSSPSQFSDFTPFFGNFDQNDNADDIFYEQPFAATVEELPYDTPEPAHFMPSQYSLPTDLFQPTLYPQPSTSTYTCGIKRPNDFDDFDVAYKKKVTETDVIRTNDQCSDSGSSLESLFDESFLDTDQIESALNSLDEIDPSFPDLLISTDVQDILGQIEKEAEDQKLEGFDFSDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL07</accession>
    <name>A0A835GL07_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_006085</name>
        <name evidence="13" type="ORF">HW555_005557</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000234">
        <property type="protein sequence ID" value="KAH9641469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL07"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032681794" description="GOLD domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9417341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9641469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="207" mass="23384" checksum="DFFB6AA5ABA9112C" modified="2021-09-29" version="1">MKSSWRSLSFTVLLAATLLHTGNCYTITVDAHAEECFFENVEADTKMGLTFEIAEGGFLDIDVTITGPDGAVIYKGERESSGMYTFSAPTSGRYTYCFSNKMSTMTPKVVMFHLEIGVAPQGQPAGKEEDVNHNKLEDMIKELATTLKTVKNEQEYMQVRDRIHRAINESTNSRVVMWSIFEACVLLVMTLGQVYYLKRFFEVQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL08</accession>
    <name>A0A835GL08_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_004783</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2096"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2695"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9418353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="3004" mass="347979" checksum="386CF2824D5C2333" modified="2021-09-29" version="1" fragment="single">FRFKEVSRASLSACPLHSSLVPPASSIHEHAVSSDQCAADQPHAADKGRSLPVRALQQHGYEAQSSSVMELHAQHHPQTGVVAEDDHAQGDDELGNEQRAQHSGQPRAPVSTEREHAPRHPTFCSTMLAVILISMAEEEKEKPEEFVKIVPSMVKRPKIAWSDDLSHDSEEDRERERLAQLERELEQTPVKPIYEPEELKKLVDYVVRMTTIFDLRPEDWTEETRDQIENWFLEPKNLILCIYFKGDKLKASHDIPLTPVYDLTYFIRPPDFVFKAETFHDDIVFGTFRDSIESNVINMMEYVYAPYFFAITTWPDSVKSEFCTHIHTFLAKLTDMYYKMLGLTVLYIPREGQNLSFEKASADRELVKRLEGVVVYWTHQIKSCLEDTAFVASQKELLCPSDEYDFWIYRHENLNALLHQLKNPAVKHITKILVTTHSTFIHQFQTLCEEIVRKVREATSNIEFLQIIKQPCAVLECVVDPDEIAKHIPNIINLFRFIWMESPTYNSETRITNLFKALSNQIIILCRNYIKLDDLFDGKTIKALGEFSKCIDCCKKYREIYDVMAEAHNEENPNSWELDTGSIFNYIDSFIQRCFDMLDVCNCMIIFGRINEYETISKPCFGGARGEQFEAKCEKIERMFFSALLDVKGVVNTILDVQAPSWYDDILAFRTVIKDIEIIIENLVDTVFEGVNHVEEAVVALYSLNNYSKRKNLKRVFRRKTSEMWSMFSEEVQESKKDMVSTRSHYPADMPSYAGRASVLKMRKNRLLYLKNVMTDASAWLLPCSSSEDVIMHVNRLMGAIDVAIRELWIAWTHNLDENCGAGLNKTLMRKSPDNPGLLECNIDVSTVNYVYESVLAVVKGYNKILESLSDEERLLFRPLIMACEKKVQPGITKLTWTSTMSDAYIADCVTQIGELQDFLTTYKNCNVNLVKIMEKICDTPFVEFDIYNVFEIKVLRQEIRKMENAAMDSVLEMYKLIVIYLVIVYEGFEAHITQMAEHWIKYVRRFDILLEDALRLGIKSTMQNMYKCVHGDGTMAPSPLLKMDLYLVGKNITYIPSALEIRDTFTTVLEEIVHIMSTIPRLYQKLSLPAAGLKMFFEVVALDQDCNKLQKLINEEIDYNIELVIEHLTMWDPYKHIWTVEKDDFLTKYRNEKHTAQEFDDLIINYSNLANSIQIQETVNQIHFITLNSSELKKSIISHCIIWQTKLGELLRTITEADIDVVYNYVEKSSEEAMKVPKDLKELQVSIETYDRLISELIQMEKTFPPITDQMLTLAKFEVELGSDMTTRHENIPVLWEQYLSVLEEAKKNLEANKDKFKTGLLDQAEVFKEAAKEFCEEFYKTAPVTSESTGKEALAQLKAFRDQLNALRAQEQAIRDGLAVFNLTTPVNLDLLKMEKELEKLEEVWGLVNQWEESWEKYKNQTFWEMETDEMEENVMYLFRNLNKLSRQLKEKNWEIIDTTRIKVDAFRRTLPLIGDLKNPCMRERHWDRIKTLMGVEFDQNSEDFKLDLIMKLNFQAYAEEISEISNAATMELNIENGLKAIREVWKSTTFEMQHHKGDIYKIKTVDDVMQFLEDHQVQLSSMKSTKYVEPFIKEVDYWEKSLGYISLQVQRRYLYLETIFTGEDIRKQLPAEVLVFDALTADWTEITASMHAGKNAIEACIYKPQPYLFNKLNQMVDNLDGILRALEKYLETKRQLFPRFYFISNDDMLEILGNSKKPSLIQVHLKKLFDNVTRIRIEKTKVIDFIEAPMTFDPIKIYCKRNLLKLQQSRNNAKYQDKDLRTFKSVHRIACCKAIYSHNWNKLLYLLKKCPPWEHNWKDVNEAALYSRALLILIMYHPTSQALGLLNDYLHLVWSCRSDDVKKAVLKILLTLPEKIHVAKAMTSEDGECVEWKYNLLLDGPAEVWLQGLEHTMRVVLRDQLILTRAALRKCRYQREQWINDWPGQLGITASKIQWTSECTRTLCRCEIMKEKKPLKKLRKKQNQILTTLQMMSRKEISKILRAKVNALCVIEIHSRDTVDRMYKMGCMNVTAFEWFSQLKFYWDREREDCYIKQTNTNSIYTYEYIGNSGRLVITPLTDRCYITLTTALHLFRGGSPQGPAGTGKTETVKDLGRALARWVVVTNCSDGLDYKSMAKCFAGIAQSGCWGCFDEFNRINIEVLSVVAQQILAVLLALSLFQKRFTFEGFDIKLDSNCGIFITMNPGYAGRTELPDNLKSMFRPIAMCVPDSLIIAENTLFSDGFTAYKINAKKVFTLYQLAMQQLSKQEHYDFGLRSMVALLRYAGIKRRAYPNLPEQEMVILAMRDMNVARLTAKDVPLFDGIMQDIFPDVEIPTLDYDLLETAITAEMRLAGLQPVKAALHKVIQTYETKNSRHSSILLGDTNTAKSVSWKMLAATLTRLNREKQPGFDVVHTFPMNPKALTLGELYGEYNLATGEWKDGVLSSIMRTVCQVDAIWIENLNSVMDDNKLLTLVNSERISMPSQVTLLIETLDLAVASPATVSRNGMVYNDYKDWGWWPFVNSWLETIETPEYRDVLRRLFVSILTPVLELKRVSLREGESVRGQELTGVRAMCRLLGRQPDPAPAAGQDNADIEGISKMRFLFAMIWSVCATLEEESRRKLDNWIREHEGIFPLKDTVYDYYVDERLAQFKPWEEQLPDNWRFNPNAGFHMILVPTMEFIRIQIIALDMLKAGYGVLIGGPTGTGKTYLIQGTLTSLDPSKYSTQVINMSAQTTAANVQDIIEARLEKRTKGNYVPAGGKKMIAFMDDINMPVRDYYGSQPPLELVRLWHDYGYWFDRAKQWRKNVKVGSKLSTKLLFNFCHKRWLHFGVVEFYMYFTKTVTIKEKCLPWITENIKFMMNLRDRAYKQVNINNNISYPKTLWKNLKSTLLPSRNDMDLPPHFNDPDKINENFLNVPETNFCTESSSLTNIFGAGKTVLIATIDMFNNVVAKLLPTPSKMHYLFNLRDISKIFQYIFHDSYSCGCPIDKEIFNRQRKMKEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL53</accession>
    <name>A0A835GL53_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hyccin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL53"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40986" checksum="8A1092D83C4125EA" modified="2021-09-29" version="1">MSEWKQLISEWLNEYAALLDNEIKSFAAEHEHNHEIATAIFNLFYSEDDSGTNTNKLENESEYEQILENVCTQLFSFYRSKEVELQRFTLQFVPTLIYNYLSSVAQGSKRTWRCIETLLIGLYNYEVVDEEGKPKVVQFRLPSLAQASIYHEPLSLGSQFLTESALRRWEECNTKLVSWGPFPQVEVINAQNRLKVMSALLFIYNRQLSLLPKLALRHFCIAASRIVTQGFNKKITSASGKPVPRIPVSSSFLLEMIEGAYFAMFNEFYTLAHQAVQDIDQRAQYELLPDVMLVTSAVINSLKNNPSGQPCDGPMGISVALSPATTTVTMSKSMITNASFRTKKLPGENKLILIMTICYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLS5</accession>
    <name>A0A835GLS5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLS5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.210:FF:000002">
        <property type="entry name" value="Blast:Glutaminase kidney isoform, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="11">
        <location>
            <begin position="131"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="694" mass="77903" checksum="106910BD279A70CE" modified="2021-09-29" version="1">MAQCVVRGSVGHFARYSAQFVQFTARTHPSQPSRNSGMRYLYNSGFEEFMMECDNSFEAAAMSTRQLCRLVTARPLAKPNHSICTCYRHYSQVRPVYVISKPEKWRNSAPHFYSVQSLDMRAREGPHKNADDVLFDMFKNEDTGLLPVGKFLAALRTTGIRKNDNRVKEVMHNLYKVHKQSNFEGGSPETLKLDRKTFKEVIAPNIVLITRAFRSQFVIPDFQDFIKDVEEMYWAAKSNTDGKVASYIPQLARASSENWGVSICTIDGQRFSIGDVTVPFTLQSCSKPLTYAMALETLGPDVVHKYVGTEPSGRNFNELVLDYNMKPHNPMINAGAILVCSLLKTLDRPEMTLAEKFDYVMSFFSRLAGNESLGFNNAVFLSEREAADRNYALGFYMREHKCYPEKTNFRECMDFYFQCCSMEANCDIMSIMAATLANGGICPITDEKVLRPDSVRNVLSLMHSCGMYDYSGQFAFKVGLPAKSGVSGAMLIVVPNVMGICTWSPPLDPLGNSCRGLQFCDDMIKRFNFHKYDNIRYASHKKDPRRYKFESAGLNIVNLLFSAASGDLSALRRHHLSGMDMTLSDYDGRTALHLAAAEGHLSCVDFLLAQCGVPHDPRDRWGSRPLNEAETFGHTAVVQYLKEWELTHPTDKTVAAAAGASDVDDILKVKPDADDAVKDPSIQEIVSRNGDKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM64</accession>
    <name>A0A835GM64_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM64"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13802" checksum="1FAF559DCBFB61E7" modified="2021-09-29" version="1" fragment="single">MSNAFVIMLHYNVVLGENAYWLNSYQGRESSSLQSDTQQILPYKRVEKPTVALERHGYTQDVYKEEAKDAEVVLGDMLRVLQQYFVRKAPQDKTAKIPSAKEQKQNGNHNIAWSYYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM72</accession>
    <name>A0A835GM72_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM72"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="94" mass="10430" checksum="B9294319F8D4B3B4" modified="2021-09-29" version="1">MTVCESKKKKVEEEVTIDLVDDDNTENVGVPGAAMQDAEKNDQVPEDEFGAKDYRVKEAACGHGNYGFGNDFQPASSNSIEQEWCGLVKFRIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNB8</accession>
    <name>A0A835GNB8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNB8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12219">
        <property type="entry name" value="Ubl_TBK1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000100">
        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000106">
        <property type="entry name" value="serine/threonine-protein kinase TBK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041087">
        <property type="entry name" value="TBK1_ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF15">
        <property type="entry name" value="FI05319P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18396">
        <property type="entry name" value="TBK1_ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="714" mass="78650" checksum="849A9F0E9EBC5913" modified="2021-09-29" version="1">MRIKDNLSYLSRDQTVINVGKDVSTESIKMSFLRGSENYVWCTTSVLGKGATGAVFQGVNKNNGEPVAVKTFNQLSHMRPHDVQMREFEVLKKVKHENIVKLLAIEEEQEGRGKVIVMELCTGGSLFNILDDPENTYGLQEHEFLLVLEHLTAGMKHLRDNNLVHRDLKPGNIMKYINEDGTTTYKLTDFGAARELQEEEQFVSLYGTEEYLHPDMYERAVLRKPVGKSFGATVDLWSIGVTLYHVATGQLPFRPYGGRRNKETMFYITTKKASGVIAGTQTTENGPIDWARDLPSHCQLSVGLRKLVTPLLAGLLEVDPHRIWTFEKFFYEVQITTSTTPVHVFHVNKAASIKVFLKPDEKFEHLQTYICEQTSVVAESQILLYKDQLIHTVIDDNTLGKEYPETTAEEPLILFNKNNNNVSMAPEPEVPKFPVFPNIVSVENDASQAKTACSVGHVIKRRVEALCAASVLCGACVARWTALLGARLAAVAARAAQLAQHACLAHTAARALDLAPGAGAGWAAAAGLLAADAGSLRAAAAALLQRHAAPALRAEFDAAARLAPCPSDLRLHIKAKTLVDRLRESWQHLVRDRATRSLTYNDEHATILVPPRLAAARRADAIADWYKVAQTVYLQTQILDKDVSSAELKLLTLAARIQDAEHALRGQLVSPRQLRAPHSPRRPGAAVAALAAAPTWRSSCSPSGRADLAQQLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNG3</accession>
    <name>A0A835GNG3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNG3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13160">
        <property type="entry name" value="PTB_LDLRAP_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF57">
        <property type="entry name" value="RE46159P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="196" mass="21880" checksum="C3859A3CAA931F77" modified="2021-09-29" version="1">MSEKEEHKEGPVTAEDLPMTFQVKYLGQSDARGLWGIKHTRKPVDLMVSAAKALPPGQALPMVKLMIALDGVHLEPVSHGTKTDEFDQMSVFFNIESISYGVQDLVYTRVFSMIIVKDTADVKGLNPFECHGFVCESRNAARRLTYALAAAFQDYSRRVKALQASSEYEEPAPTKPRFAIDLRTPEEIEADLETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNH6</accession>
    <name>A0A835GNH6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="348" mass="38494" checksum="5883EE265499E985" modified="2021-09-29" version="1">MGNKDSYENLAVSSGNYIEGVNPLPNDADLEPVSTFWYNAPLPEKSITAAEPETEPTFTSPTRTLLTLESTTVMLREAEPASIACRDEFPLVEHNTAAEPEKELTSTSLAKTPQTLENTPAILPEAEPTSITCYNDETLPVGHNTLTEPETEPISTSPDRTPPVSSIATAIVPHSDPPIIACHVETLPAGYNSTTEPEATNSRPVLVTEANTNPRKRKRNPEKWSQTQKKIKLNTGQQPQKQMQEPCKCKLKCFEKIPSDRSEYLVLDTTNRTTTTRTRKSNNANAVDVNELPLAYAQLLPISDALFKDLISLCNTNAIPLHYQTFYRNLLPVTESPNLEVFDSSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP45</accession>
    <name>A0A835GP45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="20203" checksum="39A697DCEC88C0CE" modified="2021-09-29" version="1">MQKLELTLAIIKPHAVSNPVVLSFIRNLLKHKFIVVRTKRVNLDTETACRFYKEHFGKFFYNRLVTFMSSGSIDLHVLGHVNAIGLWRQMLGPTSVYKGQFQEPHCLRGMFGISDTRNVAHGSDSHESAEREIKFFFPDFSFYHWRNHDEEWYRKGPIVFNDHHFQHVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPT6</accession>
    <name>A0A835GPT6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sperm microtubule inner protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPT6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054323">
        <property type="entry name" value="SPMIP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826:SF1">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22589">
        <property type="entry name" value="SPMIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sperm microtubule inner protein 1 C-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="26456" checksum="79639FE53640ACB2" modified="2021-09-29" version="1">MPPIDMTNPDTIKFFIENYEKTARLRMKWNNLYWDKLNQAATLTREEKGYWIEDVLKETMAEGLPTITRDNTSGARNKRKKPIRDAVFIPGINDMKKGHSIVDVGLADPKKDPTVERPDTDLKPDPVMRPINPKHKKLIYKGLPNFGREVYLKERTRIAPEDKYYFRECSGWEYGWRLQDSYFSRHVPQYGRVWLLTRDAASRSGPQPDPDHYQTIKLPGPDKCNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPU4</accession>
    <name>A0A835GPU4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_002443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPU4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9421762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="45921" checksum="91E1CBA3A3A99C9C" modified="2021-09-29" version="1">MVRYGLIAFAPILIFRIRCTLYLCMASTASAALSWIGLTMITKQLWYLRKILKTVISAKTFLFLRLLGGHYSKISSNRLVCAVGVVYCTMFSVYAAMHMLELLARNMTPTSIQTISSVTLYLSSVVTSLRYPEYFQVYLSDMADIDILLRGKSELDIPFTRFLFLAILVTQVSLVGPYIILGYLENEEKIQVSNFLFVGYFVLQCGIIYLTAVMVFEILWYRVRKFREYLEKHLPQLCRAQDERTAADDIYKCMLLYQTILEAFKKTNAPTKTAILMATTISFCKVLAGVFDLISSTNTHIKLLRVHESALDGVLPLVPAMLAAFIQGELNRIKLFIGNLILNANEESVHDALRDCQLYLEHRPFKYSVCRLYTVDLSLVITIINLYVTSLIAMIQFSHFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQD0</accession>
    <name>A0A835GQD0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002994</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQD0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000576">
        <property type="entry name" value="CBN-SEK-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="47"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="37793" checksum="A3747F64345323C8" modified="2021-09-29" version="1">MSRRKLPPPGFNFKPPEEQIVTPPRNLDKQTTITVDDKTFTVHADDLIKICDLGRGAYGIVEKMKHIPSDTTMAVKRITASFNSQSTELKRLLMDLDVSMRASACPYTVHFYGAMFREGDVWICMEVMDMSLDKFYMKVYHNNHTIPENILGKITFSVVSALHYLYSKLRVIHRDVKPSNILINRKGEVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIDPSGNPGQYDIRSDVWSLGISLIELATGKFPYNTWGTPFEQLKQVVKDDPPRLPSGQFSEQFEDLIVQCLQKDYKQRPNYDALLTHPFCLGHSQEIDVATFVQEILDLPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQP1</accession>
    <name>A0A835GQP1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQP1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042609">
        <property type="term" value="F:CD4 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055287">
        <property type="entry name" value="IL-16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48484:SF2">
        <property type="entry name" value="PRO-INTERLEUKIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="769"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="891"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="984" mass="107499" checksum="E9E90CAC29FB328C" modified="2021-09-29" version="1">MKPEDRVNKSDAEDKSLSNDETPLPSCPRQPPDGVETPSEAVEKTPEPSSRLPLRMPAGWPGARPRFSYTSRTQDARSEASVKDKIAMFSNDRSTSTDHLDKCGTLPTRNSSTTRKSTVSYASSYTDVSSLDRRLTKSQDNLDELPRSYKRHSERPEVLGGVERASTASTYNSTKSSNNTLYTETKPLFYGSTTTLPTSSDSTFAKTVYHVRSVSDDNGNKNISKHKSNLDYLIEQRKKSMSKLRCLVIPEVQTPIVDLPEIKVQDVLSKSLLLKNNQNNTSAKVNKPNNTKPINLNDTKWKADLLPNNLPKYSPAFKRKSLQVYTPSTLSKESTPEPNYNERLDALNKSSYKPTKSLRSSVDTNGLTGRVSTTSITTNKILSTDINAPRKDHNILNYIRDYKNLDIKNCTATDVVDSDNDSAMSSTQSSYRSSASSPMHNIENVESDSSRLSPRISHYTTYSVFKSEVPNKTNVTEKTTEEYMKRNVCRSVSSDTNVSLSSSAGSAATSGSQASCSSLESSVADSDKRKVSKSYNIDTINRRNILASAKCRSGRDAKLKSPVVESKFSHESCDRSPSPVHKASERLSTLTPSVSVVSNKGETRRRNKIIAETDSDSDSDNNVWQRKNDYKNTRLKRNSSSANKNKQSDINLETSKVEDGPKVISEKIIKEIKKAGLDNYTNNKTTSLIEKNEFIMKKSDNGLINKQEKNIKPEVIEHHKAAIDSIDGNCVNLKNKEKTTELLNKIEIDTPSDKTDISSAEEVKVPTETIRLRRGAGTGVGVILAGGIDCEAKEVTVHRVLADSVAAKAGLKRGAKVRSINGCVMAGLTHAQSVSILKEQRSEVVIEIEIENRQNANGVEGGSDKAESKVRHEVEDKDLGEDSKTTGAVVTVLLEKAGGGAGLGFGLDGGRDSPRGDRPLTIKKLFAGGAAAQSGRVLVGAELLSAGGQSMEGFTRTQAWAALKALPAGPVTLVLRNPKGNMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQT3</accession>
    <name>A0A835GQT3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQT3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="340" mass="38406" checksum="8C3F18C7ABDA944E" modified="2021-09-29" version="1">MSSTQRQKLSRAAFLTHFRQNGVYDICCRKHRYGNGEDYYYNPQNLTRATLSGIAAYRSALTLDWLAAEDQRQRELAAAFETEPAPPARSLSTDCISYARPASGKVARLMLEVLKNLEGDEGNIVTDLIQALVRTKLLVETSMLDAEPDLDSLVKTPGVMMGEPHTTFPRILAMTWMTVTDPVTTKKFGWCPINKVLKVNKYLTISKPVTIAKQMKALEPVIARARFIMEEFIQHVTPLNMYQKKSPETVTSMVKLYSEETPPTTDVYFKSMKRPTRTYNTVRAVHVALAQSATTPPLEMEPMPRDIDAEILSSSALKRLQHLPHTLVAFVIVFYVINLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR20</accession>
    <name>A0A835GR20_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(+)RNA virus helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027351">
        <property type="entry name" value="(+)RNA_virus_helicase_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01443">
        <property type="entry name" value="Viral_helicase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51657">
        <property type="entry name" value="PSRV_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(+)RNA virus helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="37249" checksum="0FF6EDE6342ACDBC" modified="2021-09-29" version="1">MAQAISGTAEPPALQGGWAVPKIQWVNGVPGCGKTTWVVSHFNEEEDVVATTTTEAAKDLREKLAHRLGRTRTRVRTMASILSNGFRAHDKCHRIIVDEALMNHFGAIVMAARLSGASEVVLVGDVNQLPFLDRENLFQLNYTRPNVVAPITHELSCTHRNPMDVAYTLGEIYPGIYSSRTTQSRVHSLRVERYTGAKIPRLAQNTLFLVHTQEEKADLASQGYGSGEGSRLLTIHEAQGLTSDNVLVINTKTRRLQIHESVSHAVVAVSRHRVSCVYCTDDADDAAGGLIKRAMEANTKMVVNYNLKMAMKHRDAPIIEEMLDLVKSLVGKGHPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR97</accession>
    <name>A0A835GR97_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR97"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="53"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="374" mass="42738" checksum="A9DAC9A1F4DCC839" modified="2021-09-29" version="1">MKQVCDGVVAHHIFYFDGNFNDRHTILIKPSQFLFHFNFQILCNMNKLKILFLIGTCFLQCKGREPFKPAHGSLPFLVYFQSRYRGICVGTLVSRVTVLTAAVCVTSPSADFKDTRPINVVTGTTYRHPRRGIRVQVTKILVPNLARIASGNRGYLMSKSVALLLLKRKVPDILTEIPLRPLDIDFKGEEVLSLQEECLMPGWHFFYKGDKIYPVHKFLLQRNVRVQYVNLVKKALWCEALSIKFQKALSNLGFLGLFDKAACICVRDPDRIAQPCHGMYGSPLICRGRAVGMMMAPDAQWTNCTGFSNIIHILSSNYLREFMECVSTLFEPEEKPNWVMMKKQLYEDFKEGTYDYVPEIYDKLTSSSESASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRE1</accession>
    <name>A0A835GRE1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rotatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029249">
        <property type="entry name" value="Rotatin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14726">
        <property type="entry name" value="RTTN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rotatin N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1312" mass="148838" checksum="04BF9177CF40FDB9" modified="2021-09-29" version="1" fragment="single">MANAEILTMYIKKLSHPLKEIRERSLLLLLAKLKLGWELEDELSGTRELLESLLAWFQTPQQSLQREALELLLTTIKTKSGNYIAKEFGIDTILNNLNKIRHRISIDALELYDDVIDTLRFINTVESDVNVDIPRLTLPDITSSESDGGSSSGYYNLEPNIHSSKTTSISNDDSDFNRYRNLHTTECVRVLLFPWVELSQSDKKTLLLVEDALRLLKSTRRCCRFIRDVFFSLLTIADGNHGGRPGEALCVLLYITKALRVRLLQLSSLDLIHEANKVSEDHRDLIDEGVNLELEEIAGEPHPRTPAEEDGLVLLRQLPAPLYALDTLHAVLTIMARSVVLADPVDKTEFLNIRELNTCLCLIEGLVELLLDCINDSFWIMDHNAKTYRDISHKSCMAMRLMGDLLNKYRKSFFDDLDRSHHRVAWLRLTFCAEKLLHWARDSALPPTSLVNALQVAQLDPGVELFYPTLSKKIELVLQSTKITINQEYKSKYRELKKLFSSMDGAAQFMNNKKLHKSKKVLACIKMNIFLVDIADILVKKAKDLEFNDSDWSVARSIALSLMGHSVDWVQITFYKSLAEMVKSVLVGDENETSLTLLCDVGILTEICCHGLSSKFKEVEESSSDIMLYLLRGRLVLSEDVGGDYWLVCCQYYRKAICKSLERDIADCLGVSASEVMAGLVRLLFVRCVAVQLDAAHTLCRLLDDERYLPPKDSLRADVLLSALRRVKRQEFNIDYESSPTKVPQTTGLTQILDVLKQDIVLDDEGHYISRNTMQPSLEPSLRRSTLQQLAVIVRQQNLHDVFLQYDGVNIIVATLRMSLMVDDYLAFPECAISCVSILNSVCFASRHNLAKIPDLPAILLRVILVFPANDSSVLMAAQVLAITAWAGFALQELDASRHRIPALPLNVTQRTSLPFEANSYWNTSPNAEHSSVEWLLADEEWRTAVRVRWWYTNSGRARLLTEPPPSAPLSLRPTTRDLATLRASCPIFSSTRALLALQNATTHRQVTEALHLLESYVYLVASSGVNKKEYSSLPWQHMRRFLDAPPASSRDTSLLCSLLHFVIAYMDNVPKSDSTMSWIKSSFIGNEAHIISLLSREQLYPQQTAQECIEVTQLHIHIVKVLLRCVMMLETWDDYDTHKLESLLKILLACLDRIDLKNFHMLGYLNELMRCIRYAVNSRYCKLSEDTLIQCLAVVAKTLSGCASGGGCKGQACRLDATLSLLALLRQIHEEAIPVQRWSEVFNSDVVRTVVKSVSGTRPQLRAAALHVQYKSRLYPSLLRIYLLSAVKRILCELRRLPFLLRLRRELRHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRN9</accession>
    <name>A0A835GRN9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRN9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF132">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="51362" checksum="D63FC7ED0AD611AE" modified="2021-09-29" version="1" fragment="single">NNILSVKLDVVDCGIDHALDVYEGDVELKYYPWVGILFYSYYGEEGDSRAVTSVILIQSEFVIAAAADIGPMPKRNFRRSARVLLGESWSRPGRRVRNYVLHPEYGETYNTVALVQLSTPIRNVNIRPVCPPPNLLRNPTFYVIKMKEDINVLSKEVIRVMHIPGDMCKEFYVAANLYSKKMRPPHVACAVSADTSEVCVWGAGGALVSRDVWGRWMLLGLGVRGPGCGAPSRYLDMMSYYPWIEKSLDDFNRVSLSKISKKKYVLRTSSIYQRFGACDEEEKINLVFRETIVLRTDNNKYQYLTYNVTLTDNVEYSCMTMELVNASAVSEMRIKHFCNRKNFEQPCYFYRDKCLFEMYLWGFKKNMTLLDIQEWKWEEGTYYEDFTMQRVEYRGPSYMTDFGFEPLDIGMWVPEYDIWTTTLLDNSTTPTPPPVKAFEIPIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS93</accession>
    <name>A0A835GS93_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032903707" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122941" checksum="8A5A10EB06878A77" modified="2021-09-29" version="1">MVRGAAIALLLALAWACSSHGSVLVPTYVLPPDSFVRDQRSLGAPPAHDTQHAESQRTIKRLVGGHLKIKPEKEYGAAKNSLNYNEKTSSGKFAGVTAPDQSGGNVGWNQGIWDDGMLMSSAGEGKDAPKTKEVDEDKKTLADQVAEGKYGLIQNEIFSKNPKRPGIVSYEPNAETRAKDNLQSLGGLKKDEIWLAEDHLLVIKGGAFPERTKETEGRPWPPIDDYQAPNRQVKLPQKPKVPPPFPVRLSDNGPLVFLTPNGSVPASLFPSFFTGEGEGPLPPPPFLFPSGAPYPASDYQGNTTTGGAPQPGPPFPFLPGNASEGAFPFPPSMNGSFPEGFPPGAVFLPPPSNQTDLYDEDDPSIYYPPPYNFSYRADYNNKVPAGPLVPGIVLPPPPDFFAPLEENTTEAVKTTTARPTTVNTYTRTKTTTRPPTTHAVQRTKYKTRPTTTTEAPRTTEIPSTITTPPVDIITTLKTRKPQRIPSRHPVRIQNLPEEHTTRTKTEKPIYKTRTKVTSKPLSVSVIYDYPEPVYDNKVPTTSEKPYILYDVPQRTPAVTTNEISSTQIPLRAHYSNVHSDVPTTKLQPVYNNRKPNENAFASFYFYDEQPKTTPSPATYFDGRNYYKTVPVNPTPYPQQQNINTQTGFNPAVDISYGAIDQADALFLWPQKQGPRTLTQEYFSIQKPRPQPVYVQQQKQRPDAFYQQIADIQQTIDFFTTKRPKAHSHRPHTHKPKAITGRPVYQFSYQSQPRPEQLPFRAPKLDPEPFRPMVSYSKPFNLANDFNAITPSASPGYQQYLVENVQVTTESPTSSRYYPTTKTQDDDYEDAAFSKDKKNRNQIQGDQPAHVRHVTRYPNTTPNPVSQGYYTKQDETYFDDITKNSFDVFGKKLEDNTHDVNGLAVTAPLDTVRTPINNNINLQYAYELVENQSPNPPALDRDTLVNYRLPRPTVNPESEPVPQVNADLVQQKPPSLADDTLVNDRFPRPTINPDSEFIPIANPGYRTAQQYRAPTQVQRPQFTGEQYDLNRPSLAGDTAVNYKRPLPPVNPDAEWIGPVNSAGEGRPGSFVSYRLPGEGAHVYFLTPQAAQAVRDRYRSPGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSN4</accession>
    <name>A0A835GSN4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSN4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000142">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="12">
        <location>
            <begin position="413"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="784" mass="90877" checksum="2D1447A21412E6FD" modified="2021-09-29" version="1">MVHGFDLQDKGQVTFEDKWPAMRPIVLKLLKQETVTQTEWQDLFGSVHSVCLWDERGPYKLRDALQQDIMMYIKQAQNRVLAQREDQALLKAYIAEWGKFFTQCNYLPTPFRQLENSINNVSKVSSSNTSSTQKKNNNNNIEDSLVRKLMLDSWNQSIFMDIKQRLQDSAMKLVQAERNGESFDSQLVIGVRESYVNLCSNSVDKLQIYRENFEAAYMQATEEFYKLKASEQLLANGVQSYMKYADQRLKEEEARAHRYLEPGSGSVAALTQCCEKVLIGEHLPTLLAESAPLIKAGETEKLQLMFRLLDRVPEGVTPILRDLEAHIVSAGLADMVASADIITSDSEKYVERLLDLFKRFSSLAKDAFLDDPRFLTARDKAYKCVVNDTTVFKLELPSSALIRGSKGTAPESKCPELLANYCDMLLRKTPLSKRLTSEQIESRLRDVLLVLKYIENKDVFMRYHKAHLTRRLILDSSADSEKEEDMVEWLREVGMPADYVNKLARMFQDIKVSEDLNTQFRTDTTRHDAINIKILNAGAWARGSERVTVSLPLELEDYIPEVEEFYKKKHSGRKLQWYHHMSNGTITFANSVGRFDLDVTTFQMAVLFAWNQRPMEKISYENLRLATELPDPELRRTLWSLVAFPKLKRQLLCHEPVVQNPKDFTENTTFWVNQEFALVKNGKPQRRGKINLIGRLQLSTERSQIEDNHSIVQLRILRTQEAIIKILKMRKRITNTALQSELVEILKNMFLPSKKMIKEQLEWLIEHKYMRRDDEDINTFIYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUH5</accession>
    <name>A0A835GUH5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35121" checksum="2FFCD016CC33CBEB" modified="2021-09-29" version="1">MRRTTTAMRNHLKAMHKTEFSELEKCEKRKYDASKTLQLASSSHQSTKSDMKQISLQECIDKTKQWDNKSLKSLAVDKSISEMVALEDLPFSFVESVGFVRLMKHLCPSYNLKSRQYFTSFICDELYGKQWEIPKEKVKCVVRDEGANMKKGVNLLNVKHIDCAAHKIQNVPFDELTKELSSADVSISSVIPLIATLEKIVGDLDATDEYIGDTIAVLKDELIHKFSGLENDLWYATATFIDPKYKSKFFKNMAIKERIIEHILDLVGDNPTDVSANSRGTNAKRVRLNETEDFPTNKRLYKFTMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVI6</accession>
    <name>A0A835GVI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 112</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="45826" checksum="1BEED919FA6208C5" modified="2021-09-29" version="1" fragment="single">LQNVLAKICKAPQGNEVLNLPSPNELKHFTEKAKNKYREIKLLFQDIQTGTSSKELLQTLDIDDVKKSTLELENRIKSLKSYLQSELARLKAAEIELNKTAKEDQVIVNNCKKNLRIQTAKYNEIVPSPVKTLITSPFKCEEVQQFQEFMLNSANRYGGWNEYHHNIFVNHWQKYFSASIDGSHNEKIDNIQHYPGYDKFLSEVLPKLQGIREQDIISHIQWYLKFVFLKKQQQRAIDQWRSNRRIIKSATKELPPHKTNEMDKMKTNRRKSANDISYNSKRDSIGHSANQDKIRKSKQVSNLEIYTRFTRLTLSYSFSFSFIRKCYSEDMTNMKNVEKVLETDDETINTFKWLQSNGVAELNSKEVENKPNTNSLENIKKLRIPDWRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWR4</accession>
    <name>A0A835KWR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000699">
        <property type="protein sequence ID" value="KAF9405678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33966" checksum="D7791CEBF2953112" modified="2021-09-29" version="1">MANMSTEETFKFLELYQQKTACGIPKINTTKIKMLTNLKKRNASIRSGAGTEDVYQPIWIFYDVMAAFLTDVYESTSILNTEEKTQPDLYEEGSASNVQVSDNIPDAKNEDHNDANIPTTSQNKPIIQSQKRRAKDPPEMQEANKKMSTAFTALNKALANKENIKEEDECDLFCKMLAKQIRVYPKLEREEIMYELHGVMMNRRRRYNTMQGRSYAVSSPSQIILSRPSTSNSMYPSTPSPIYVVDSPHSVQSPPQNMANQQTEMVNIISQEVLVPQTSKMYYESCLNMTDDNNTDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYB4</accession>
    <name>A0A835KYB4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000722">
        <property type="protein sequence ID" value="KAF9405530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYB4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="607" mass="65826" checksum="C405BF89CEEC45A5" modified="2021-09-29" version="1" fragment="single">APSQAAVADSLQPGGRCMWQGAAGAEERGRCVQRAMEPGAGVASVASLTMDCEDMFKEITKKLYGEETSVGVGVGVVGVEFPAAERDLDDELRPEEHITAWGLAALMQNGFPPPGILQARIFPRIDPSAEDRWTAAEEPLAWAHSRIASYNPAQRLFKCADCECVGFLARVAEHWLGTHSQARAFTCPLAGCGFASGWARGVRSHLARDHHSDPAAADHLLRDNPALDDLTRYLQRLKNKVCPHRYLQYSRRPAVCSPNVCPQRYVCGACPYATDRRDLFTRHENIHRDEKPFHCYLCQKQFNRADHVKKHFLRMHRDQPYDLNRIRRSSSIVKPSTAPPALHYYGKPSGEPPPATAPAPAPAPPAAPAPPPAEYRPAPTVKIERPPLAKAETGAPLHKPGASTPVATATAAIRRKGERRYACCYCAWSGVDNWCLKRHLNTHLKPFACALCEYKAARAERLATHVHKVHNKKACAKCPFLADDQHQLAQHLRDAHHIESRNLKVPSGVGRAGGAGGAGGAAAADPAAGGAGSAGGAGRRREARAAGAARLFGYLEASDGSGDEYEPPVLAPEFAAAPAPPAPHYTRDKENAAPLHHGLHHDHCLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYM2</accession>
    <name>A0A835KYM2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nanos-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_013486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000655">
        <property type="protein sequence ID" value="KAF9405985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="10">
        <location>
            <begin position="197"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9405985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="34256" checksum="93E262E16DF1E046" modified="2021-09-29" version="1">MDSVSVSFNNTEEQKPIFTLAGDQNPTSTTDSFTFPDNRNVAQDPVLSSMTPMMQGLGGSELLNMLSQQEPRAADYPPAVADMEDLLSNIRLNGSDMFTEDANVNNYFSGFGSRSESASSSVWPDAANAQSSRNSEMMDTFDFLVKSLSSANTYVSMLTREQLSVLRSIRPSLLYEFLQEVAKARSDRRMRRALPNECAFCKNNGENEECYSSHALKDLRGRVLCPVLRAFRCPRCGATGDRAHTIKYCPEGSESGSGSLSSRRRVPPSTSLLLNGAGANTSRSQGGTSAPSASPVSSPANPGLSYSSLWTNFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ45</accession>
    <name>A0A835KZ45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 14">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_003403</name>
        <name evidence="16" type="ORF">HW555_011156</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 14"/>
    <dbReference type="EMBL" id="JACKWZ010000314">
        <property type="protein sequence ID" value="KAF9409501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000537">
        <property type="protein sequence ID" value="KAH9635679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ45"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9409501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9635679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="178" mass="20198" checksum="16012D7E6E63346B" modified="2021-09-29" version="1">MLDSIFDDVKRMNKRQFIYQVLSFGMIVSSALMIWKGLMVVTGSESPIVVVLSGSMEPAFHRGDLLFLTNYPEEPVRVGEIVVFKVEGRDIPIVHRVLKLHEKNNGTVKFLTKGDNNSVDDRGLYAQGQLWLTKKDVVGRARGFLPNVGMVTIYMNEYPKFKFAVLACLAMYVLVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZN4</accession>
    <name>A0A835KZN4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_014045</name>
        <name evidence="2" type="ORF">HW555_011781</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000374">
        <property type="protein sequence ID" value="KAF9408583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZN4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="176"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9639181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="358" mass="40105" checksum="A8A8EDFCB988FF51" modified="2021-09-29" version="1">MFTLMGERVLHKCLKILRLTVADFSNLPDIKKLNAVRTVEKIIDNNTSIFIESPIHVKIQPIDVDDLKAHNKLTMTLYSQGKETSDFQVKQTSKRLELLNKNTASDRNDVCVIQVPYNLKVQVTTTDYASVHLAKLEGQEFVVKTQKGTVNVSDLKAENIVVESIEGEVKSDGRLQAGNIDLKTGLNSGITCNNIMANGFNVTTHAGSIVVRSCYSDKSHFTTLMGNLKLDSLHRSVMIDVIQKGNLHITGFSGNLQASLKSGDVYMHASQFTDKSSIFIHEKGKVQLLIPDILKNLPATNLIAEKILVDEKILKLGRFMDDSYPKRFRFEKEPHHELHVVCKNGSIELKETDLPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZS4</accession>
    <name>A0A835KZS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000652">
        <property type="protein sequence ID" value="KAF9406013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZS4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032983877" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="33"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="310" mass="34487" checksum="2F55F1EA7FA4EF69" modified="2021-09-29" version="1">MWGAVVILAVVAAASADSVLQASPELSPLDSRIVSGWDAQEDQFPYMLWLRTVRWTGDITACGGSIIHRSWGVTSARCTAQRIEITIHAGSIYRSRPRVVLQARDTFRPPGYDDAMQPITQPNDISLMRFSSDLTFNQHIQPIRLQRSEDKDRDYTGVRMTTSGWGTQWTCLELGCYTPDRLQWVHLNGISNFMCLLMHNSNYLVRPSTICAGPYNVTSQSICSGDSGVPLTAVEDDGVVTQVGIGSFVSGFGCHVGMPGGFTRPGYYQDWIRQVTGINFDQRSVPTEDPVDVDLTENEKYSKPQEEYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L004</accession>
    <name>A0A835L004_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000598">
        <property type="protein sequence ID" value="KAF9406412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L004"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="220" mass="24280" checksum="EC8B239652DD1385" modified="2021-09-29" version="1">MSSVHSDDDQEEINVDSDSRLSGHCDRSIASEDRDSEHSYHDRYHDSPNEHMTDTQPRVNLPFSISRLLGKQFEDIDKRRNSGESDDRSDQDTESESAKDEGKDNSGLPLNFSHTPGLYPNSGLLLRPGLGIGGGYGFSSNPGVVRVPAHRALGALGAWGVTMDPMRQAAAAAFAHQIVKDRLNGKGKKFTSSSDLFLINRLTNKKPKTTIFNIFFSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0B6</accession>
    <name>A0A835L0B6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Collagen alpha-1(XV) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000231">
        <property type="protein sequence ID" value="KAF9411250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0B6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010515">
        <property type="entry name" value="Collagenase_NC10/endostatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045463">
        <property type="entry name" value="XV/XVIII_trimerization_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20010">
        <property type="entry name" value="Collagen_trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06482">
        <property type="entry name" value="Endostatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagen type XV/XVIII trimerization" evidence="4">
        <location>
            <begin position="674"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Collagenase NC10/endostatin" evidence="3">
        <location>
            <begin position="764"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="100387" checksum="C7FA686CB1A7205B" modified="2021-09-29" version="1">MLVWSTVYESMGIIEKGMKDVENKRGAPGESIRGPPGPPGPPGPPGVSGTPGVVAEIAGSGDDLNNMLSYYSMDRVSFEGSLTANMSRTALPISKSRPQISHLACGHHLPRAISKRTSNLTLDNDMKVAIQQIFGENYASLGQCGCNSSTILALLQTAPELKGPPGPPGITGADGRTGAPGLPGQPGTPGERGPIGPRGDKGDRGDVGPRGPEGPAGAKGEAGVDGRPGIAGPPGPPGPPGTSDYSNFDESLLGSYGGAIGRPGAPGPKGDAGQPGPIGPQGERGFPGQKGERGQPGMGGSKGDRGYPGPQGERGYKGDRGGPGLDGRPGIPGASGRPADKGEKGERGEPGPPGPPALGMYSPEDAEFLTSGQRQAVVGSKGDKGEKGEKGGRGNDGPPGFPGKDGRDGDRGNIGPSGMPGISGPPGPPGLKGERGERGPPGPISVTMAGSDIVTIKGDKGDTGLRGRRGRPGPSGPKGSAGTPGPPGPPGRPGDKGDIGLPGWIGRPGTLGPPGQPGPVGPKGEKGDPGVNILDVSMFKGEKGERGFDGLPGLPGVPGPAGPPGPSGSLSEAIQYLPGPPGPPGPPGPPGPPGVSIVGPKGEPGFTHYEEHPVHGNTKFYGRPMSKSPLDELKALKELKDLKDRDRDRDRHGPVQSHPAVHHTEESNKSVPGAAVFQTTEEMLKLASSSAVGALAYVVEEQALFVKVNSGWQYVLLGSLVTQSAPTHPTPAPAPPPPMPAASLVHKPSISNLVESSPVPGPSLHLAALNEPLPGNMHGIRRADYACYRQGRRAGFRGTFRALLTSKIQNLNSIVRYSDRHLPVVNTQGEVLFKSFSDMFVGNGALADGARIYSFNGRNVLTDSHWPQKVIWHGSRANGERALDSYCQEWQNGDPTSRGLGSALHSHKLLAQESSHFIVLCVEVASEINSRRKRETIRYNTTGILDEDDYLYNAEEYQQLLNEIFAQPLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0G4</accession>
    <name>A0A835L0G4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leucine-rich repeats and immunoglobulin-like domains protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000297">
        <property type="protein sequence ID" value="KAF9409810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0G4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16184">
        <property type="entry name" value="EFh_PEF_peflin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000161">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000150">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000023">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF21">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032377915" description="Leucine-rich repeats and immunoglobulin-like domains protein 3" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="453"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="555"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="649"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="911"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119812" checksum="6E2619D1A4120AAA" modified="2021-09-29" version="1">MGLSHLLLFIAIIRLISVSTKAENVECPHKCDCLEQYVDCSKKNFVAVPKIPKWVEQLDLSYNRLNENVTEAFDKLLNLQVLKLDKNSFQFIPSLVHHEQLQELSLNKNNIGSIDTGTFPANSSIRILNVNSNHIQFIQEGALTNLTNLEVLKLNRNEIKSLPNHLFRHQTNLRTLELNHNKLHVISPFLFQGLSNLTTLKLRFNNIDNIMDGAFFGFKSMNLLQLDHNRIRNISKGWMYGLESLITLSMSNNLISEIDSGSWELCTNLEVLDLSHNYLLEVEGKSFQHLINLRTLNLGYNKISSISQDAFSYMTQLQNLQLNNNKISWTVEDMSGPFSKLQNLNSFSLAANHIKSINSRAFDGLSNLVELDLKGNNITSIQQHAFDSMTKLRKLHLNSSSLLCDCNLLWIVKWIKDKAEQKYVTATCAYPSDVRGVSVTKLKEENCGDSPKPKVVEHPKTHLAIKGRSANLVCSATSIPFNNMTFLWRKNNGNVSNPVVYENITIGPNGQPRATSMLVIPNVTHADSGKYQCVVSNNFGTTYSTKAKVNIVTFPRFTKTPTNVTVKTGETVTLNCAATGDPPPEISWKKDGGNDFPAARERRMNVMPTDHLFFIVNAKTTDMGIYSCAAKNPAGTLIANATLTVLQEPSFVRVMENKEVTSGDSVVLQCMISGSPKPVIKWLKDGSPIVATERHFLTADDQLLIIIGSESSDAGRYECEITNELGTKKDMTELRVLPPVAIMVNEENMAGIIIITVVCCAVGTSIIWVVIIYHTRRRMASAVHTFPAESIKMTHVVHSDSDSPQMFSDNISEHSSCKDSGTGDSAKQTSFDGVPTDRSEQVHFETVHQSYSPVPEAHKLLPSSFKPSIQPGYGGPTPQQGYGQPQGYGGPPPGQLEMGHGPYPSIGAGGGVNPQVQQWFRAVDKDQSGFITANELRAALINAQGQSFSETACNLMIGMFDKDRSGHINVEEFEKLYTYVNQWLAVFKTYDTDQSGNIEEKELAEALTKMGFRFTPDFVNFLMKRCDNGKVSVDSFIVLCVQIQRFTEAFRTRDTQQNGTVTIGFEDFLTVALSCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0N8</accession>
    <name>A0A835L0N8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000276">
        <property type="protein sequence ID" value="KAF9410128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0N8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39161" checksum="9B6691596A6CD59F" modified="2021-09-29" version="1">MIRHGEQWRRFRSKVQRPILQPQTVKKYVAPIEMVTEDFIKYMEKARDENGDLPHEFDNDIHRWSLECIGRVALDTRLGCLSPDLTSDSETQRIIDAAKFALRNVAVLELKAPYWRYIPTPLWTRYVNNMNFFVELCSKYINEALERLKTKKVTSENDLSLLERVLRSEGDPKIATVMALDLILVGIDTISMAVCSILYQAATRLKQQEKMAEEIRRVLPDPSKPLSYSDLDKLHYTKAFVREVFRMYSTVIGNGRTLQEDDVICGYHIPKGVQVVFPTIVTGNMSQFVSDPEEFKPERWLENDGRLHPFASLPYGFGARICLGRRFADLEIQILLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0R3</accession>
    <name>A0A835L0R3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_010627</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="JACKWZ010000272">
        <property type="protein sequence ID" value="KAF9410233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0R3"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9410233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="519" mass="57760" checksum="AECEF52DD8787455" modified="2021-09-29" version="1">MSSVRLLRSCLASSVAVRMCSTKTSYEEAVRKLNLLQSNKATIEQIRKDIKTGQVSIAQTPNKEKCTNIEDMEYFLSRTGVSMAKLDELSVIHIAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERIRLDGRVITEEQFARYFHQVYDMLDGTKAFEGDMPKYFAFLTVMAYNVFLKEKVDVAIVEVGIGGIVDYTNVLRKVPVVGITALGLDHTSILGTTLPEIAAAKAGVMKPGCEAYTVTQPPEAMDVLRRYADRVKCPLTVVPDYKTYTFPNTEPAHLPVNVEAYQTNASLAIQLAHAWMRITKPVHRKNGLIKHVVNGQNGLTKPVLDTVVKCVTKETMTGLTSCKWPGRYQVVESDYAKFYLDGAHTKESMEICAQWFQNINRLHDKILIFSATGDRNAEMLLQPLKHVGFKSVYFVIPTAYKNIGQNNDNYSLVEQEELIARCEKHAEIWQHFEKTCTDVIVASCVADALVSLKKNKNVDRSSVLITGSLHLVGAALSILDPNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1G5</accession>
    <name>A0A835L1G5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1G5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000084">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="60"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="35418" checksum="9D854BD40831C211" modified="2021-09-29" version="1">MAALVAFPERMLGLTLAICCPPEFLATASPQPASLSARVSDPLSLLPNSRICGIQNNDRIVGGTQADIDEHPWMALIRYDKLGDGPLRNTGLFFLHSCTFINSLCLVGKLKTQVRLGEWNTSSSVDCFHDDCSGPVQDIPVEEIIAQENYDPQDSQQHHDIAILRLAYNAQFNDFVKPICLPLSNELRNSLFEGFDMEVAGWGKTETQDGGSDSQPIYSGPNLAGTESDVKLKVRVPIVNVNRCASVYQRVSRTIDTTQICAGGVAGQDSCRGDSGGPLMGQAPSANNWMVIGVVSYGPAPCGTQGWPGVYTRVGAYIDWILSKLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2B7</accession>
    <name>A0A835L2B7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="22055" checksum="5AC7E6AFC43337EB" modified="2021-09-29" version="1" fragment="single">SPSSLWPGDFIPPVDVHIGIGGAYFRQFFDDNLLDFIVDVTNLYLMQNTGKSINIFLEIEMGIVKMPAVEDYWCKDLRFENIASPMIVKRYRCIKRYLHFCDNTNVDTTNRYHIISVVLEYIRQQCLKLEEERSFAIDEMIIPYKNKKAGSRKQYNPKNPTNGVSKFWFGDFFAYDGSHTFKNDKFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2C0</accession>
    <name>A0A835L2C0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000275">
        <property type="protein sequence ID" value="KAF9410152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2C0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="27166" checksum="05552F3BFB10CDEF" modified="2021-09-29" version="1">MEPGQSQQPEPSTSTSSGTSRPRRGRPSGANRVPLTLEERRARNAQYERERREDFAAAQAELAEAAGCDPNVSTINLMAFVITKLKNASQELSIEEHVRLNSNLEAQIASCLERLGPEYVLSGGEDDVEPDDSNTRKRKLSQEASQDEKRMRPSAQQVPVSESGPEVSTTDLAEAGPSFLGTHSLLPPLFFPSPNSSETELPSPSQFAHHTPSPLLQIETALEQEIALRFSQDDLLQIYGALDSEDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2D5</accession>
    <name>A0A835L2D5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000273">
        <property type="protein sequence ID" value="KAF9410211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2D5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24865" checksum="150D0EB7B71B60A4" modified="2021-09-29" version="1">MYHYALYSKWGSRGRDMCESSDMSMYQREPPAQLIRIACDARGSLAHLFSYFEVFWLDHRYLCSGQLRFPSNSEQRFPRRFLKIPGVDTGYNQPTIQNHARHCGMQCAIRLAPHLHYTIHAHDLALRGQSDYPELVAQVVRLFVPTVLKHQLRPRRHPLLAVPVTRTVAHANSPLVRALTMINALLVSAPECDLFAARWKDLCRECVRFCEKMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3U6</accession>
    <name>A0A835L3U6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3U6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="455" mass="51246" checksum="C871F62323328685" modified="2021-09-29" version="1">MEDVYTIKVKTKPDTRNLYPSERRYSASTVSGLAWVHIALAATSFLLACLALVSPNSNTHPLLNNNTQENAKLQTENTPILLQNENANGSLYENDFENETQINSNNETNLNSSVNGNPLNSNGTTEFNGNENDSNYILVLAPALITVFGLAAGLTSILASVRWYIDHNITWLFIMSCLSSLISLTSFIMITVWFITTSDGDITEFYKDKVPFKDYFVVKHSDIVTKNESHMIVALNSHTEPEETQNLFTKRVLSINILIAAFLEFLWSILSVKIAYKGMKNTYKDDNERRGNCISVVTKIKGNDTRKIPRNGKLLPPKPDLIDHYPSKKIKRIFLAQSDNGFYLKNEENKAKQNTETSSEFYKERMMNFLNRCASLEGLSNIENTSSVHSEALNPIPEGVTVETSSPEAVPELKDRMTPVSWGDSPDHTIYNQNTLNLDKIFKFKPTQNKSESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L473</accession>
    <name>A0A835L473_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_013458</name>
        <name evidence="11" type="ORF">HW555_006813</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000289">
        <property type="protein sequence ID" value="KAH9640259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L473"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002806">
        <property type="entry name" value="PRK02948.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="59"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9640259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="456" mass="50575" checksum="B3AE61061879338F" modified="2021-09-29" version="1">MIRLSKNIIPTVTKTLLRRTNQSQKPSILVFFHGQRLLSDTTASGKFSVQHEDFGRPLYFDAQATTPIDPRVLDAMLPYLVSYHGNPHSRTHAYGWESEAAVEKAREQVADLIGADPKEIIFTSGATESNNISVKGVARFYGARKKHVVTTQIEHKCVLDSCRALEGEGFKITYLPVKENGIIDMNELEKALTPETSLVSIMTVNNEIGVMQPIAEIGALCKSKKVYFHTDAAQALGKVPIDVNKMNIDLMSISGHKVYGPKGVGALYIRRRPRVRVEPIQSGGGQERGMRSGTVPTPLVVGLGAACDIAKREMAYDHAWMEKLSQRFLDKIYSKLTHVIRNGDAEKTYPGCINLSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGFGRFTTIEEVDYTADKTIKHVERLREMSPLWEMVQEGVDIKTIQWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L474</accession>
    <name>A0A835L474_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="886"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1606"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="580"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1621"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1631"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1681" mass="194088" checksum="C7FE88565A66F427" modified="2021-09-29" version="1">MISLQGAEEMVAAREKELTEITSQLQLLQSDEGINALLEGLKNKKRQLKFKDEGIKNLVQEANTLNNMINDLQLENETLRQRFNVPSDEKVPVKGIMKDYRNLQETNAKITKELKKLENKLVGTELSNRQLNTKIKKLVGVLINKAGYTKNKIDEIVEDSESDENQPKLEKEEVTCTITEFDFQQLVTEKQNQEKEMLTIIEENKGLRKGLQEILDFLKDNSKTSSGILTLQCPSLEAILLSMEARNSAGWFAPHMSTVMELRTALGGKDALLTALHEARKETFDVMAQLSDATKKSSELEKRLNEMEVKNREKEAEEKLLQQKNDDIEFGSWMSEKEQNDIDFCDKSQIDKLVEKGNSLYECQLKKGLEYFHIKFKELFDKLTCMAIQASDDLNKWSIQEENYKAQIERLKAQLQEDDSSDNSPGIVPIPNITCLERKCIYLEEAYKYIRTLNENLKNEILESKKDSMEAASEYETQIQKLILNVANLTDRLRYSISLELFWKQNFALSEILSKYRKLVEDGVNHKNHMLNLFSRLDEDKVNIINYIRVEMNHQKGKSTEECAQKIESNVEQMVLDKQIKQLCTELDDKNKKITSLELKNAELQEVRVKNIDETIASLTKQEANLMKEQLNNLSDENGLLKEKCQHISSQLDIALLQLQDNQQRQLSNDLEINMLQHQILDLQSTSDNKAIIARLSGEILVAHLQASESHKKLERLQAALNKERELRIQAEDMFRARQKIFDVYATRYESKFRYLYEILTTLKQQYQGSVPLTSIEKYLNKIEELSRKNRAVDEKLYEIDDLRANLISKHAVFDQILDVSKNKCLIGEDSCPHKLKYIMMQSVNTREIEHINKKLKAMERSQEDLMKHCNNLERTLVLLNQGFEKTTNDQHRSSGEDTDDQSVQMELEDVQSEDESSPRRSQTITLSKPQILQTTTNQDKETAGKQPENKKPDSPAKVSQRQPSKTFTDSLIQTDEIMNTNKLIQTDENNDVINKMRDQIESLTAEINETSKQLYEAMSLTHKRTEEILALNNEKVTYETKLQSLKESSNQKDIVNDKLQSTVNDLKNQIIDLQKKLNAEANQKRENANEENKSLLLALKQLEDDKNSIIVEYKGLLNNERDEYAKSVKDLQLKIVELQSNLDRIGRQCFKLQSELDECKSELTTYQSESARWKDLATERLTKMEQLNSQLEERHCHEVKSYKAENEHWLTQLNEMQREHMDLRTRLTDQKTVYLKQLSDKDTQIEQLRIIINNLRTQVMNMQTLISVNDPSFDLSAIVEVDEPSDVLSHRDSERLELKFESSVDLHDSHDDVMRIPASSTTIWQEPVIERLRREKQLVGKQNAILRRQIKVLASKERRARLDAQNLKNQVFRISTTGHKVTTAETAALHNKIASLQAQLTSARRETNSSIALWDKWKSLAKSSVARLEKEKRVLLTRLNEAKHDSQIIAIEKQEAETQEKPERCSKECMCSEAALPVSSQALLDRVQAQQRRIAALEIAEKGNELLVAEYERSLAEITSLKGQVLKLESTILESQIRTPLKSGGDAQPELNYWKNYCEMLKEENIQLTQKINSMETLPTTAHQHRVNDLEQTVLTLRGVINKLQAEQKSGSGHKRIDSRPSSSRSNRSSTEKGRHQSESHRLEVANLKRTIHDKDLLLERSKEMLKIAAEREDELLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L503</accession>
    <name>A0A835L503_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L503"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="786" mass="85788" checksum="6CA7C0C7D44B6E8C" modified="2021-09-29" version="1">MQDFIPARFNVAVMMFFACWVNYMMRVNMSVNIIAMVPDDSTTTSVKSECEAIVTNDTSLYNSTVVTKRELRQPDGVVTFDWTAQQQAYVLSGYFWGYSISCLVGGTAAEFWGPRKLVFVTMLLIAILTILSPQAARIHYMALVAVRFVSGLAAGFLFPALHALVAHWAPPQEKGKFVSALLGGAIGTVVTWSLTGPLIENFGWDYAFYVPGTIALVWCILWWFLVYDSPVQHPRISESEKKYILEAIGDKVNQSATEAKVVPPFRKILTSFPFLAMVILHYGSNWGLYFVMTAAPKFVSSALGFNLTSTGTLSSLPYLARMIFSLIFGAVGDRIVKQNIVSTTFMRKFFCLFSHVVPGLLLIGLGYTGCAPILSVALITFSMGSNGAATLTNLVNHQDLAPNFAGTLYGIANGIGNTAGFVTPLVTAHFTKNGNGFAEWRPVFITALIPVRFVVAIIMFFACGVNYMMRVNISVGIIAMVPRDPSNKKAKSECESTGKNATVLVQPPGTPTFNWTNQDQAYVLGGYFWGYALTCAIGGTVAERFGPRNYNDISNPVGSNVGCSSACGIQSFWWLSSALHSLLAHWAPPVEKSKFVSALQGGAIGTACTWRFSGPIIKALGWPYAFYLQECSSHLDLAIIIQRKLMRVIHVRKFFTLFSHILPGVLLFALGYAGCRPMLSVALISFSLGLNGAACLTNLVNHQDLAPNFAGTLYGIANGIGNTAGFITPLVTAYFTRDGNGFAQRRLIFLVGALLYIVTAVWFILFGTADTQSWNYPENNEPDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L586</accession>
    <name>A0A835L586_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000288">
        <property type="protein sequence ID" value="KAF9409934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L586"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="46657" checksum="941B309E20CC88EF" modified="2021-09-29" version="1">MIMPNNDDVLSCGPVDARRSQVPGPASDKLVTEGSAGVGDQAPVADNVTGNEKLSSARKRPRNPALVGGGSLDVSSEEEGLLAPKLPTARRGRQARGASVSRPRRDAQGRFVRSNTPAASEAESDMGVTTEDPGGESCASLGSSKAELNATRREQRKAVAADEVSEMARRARERRAALAAEGEPSAVALSQLALDGVDLVLKVATKSGSLKGTFTRGLKEAAADIKEAVGTLLNRTASDEVAKLQEENGRLRNDLEDLRRQVAALSEQQQRRTSTDAAPVVTPAPAPRPASARTDDEVERIVRLCLLQCGSMMNARIEAISRRLPAEIIRPPLAADARRRTEEPPRPAPRKGKPAEGAKKPAEGTPPSDQPTTAGSKGETWATVVGRKKARKAAKAASAAARAPGRTAKAVAQPARRTAKGGRKGPTLHAPRVCNSGMWFDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5B3</accession>
    <name>A0A835L5B3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5B3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="44"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="529" mass="58023" checksum="E6A69300A853E88A" modified="2021-09-29" version="1">MKWPSFLDNIPGLGYSKPTTLVVRHEDYTVGETTGGLSVLFTILCIVDLFGVFPVITLPKSVISCGIYGLPLVLSVFGLQLYTAVLLGKSWLLAQKITPDIKEKNRFPYAAVAELAFGAPAKRLVTFLIDAAVFGSGVPNFIIASQTLQIFWWKISGGEIGITYCVWMVILGLLLCPVMWLGSPKDMKPIAITSVIIVTTVAITTWTCILRDDTSPRPLFNVVDLQPQLQDFLIAYGILAFQFDIHPMLLTLQVDMKDSKKINAAVLGGFGITGCMFAVTTVLSAFRYGTDLDNNILQSIPSSIPLYLMSLLVTLQLCLSSAVSHSALFQHIEDIMKIPRDFCFQRCLIRSSIVALAVILAESVPRFDLVMGLVGSTLTGPLMFICPPVFFLKLCYMKSKMSPKNNPFYKLLEKQNGTQNGSSQNGGIKNDSSQNGDLSKSPLISVGSSTKYKTFTDYAIEIMKEEDEYAIKWYDVVLALIVMTIGIVATIVATYSSWANSIAYATFSPPCLMNATEAARSFLQLPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6K3</accession>
    <name>A0A835L6K3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003056</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6K3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032684640" description="Fringe-like glycosyltransferase domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="67"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="39066" checksum="6DE1D6365BD3D4BA" modified="2021-09-29" version="1">MARKMLKALALLLALGYCSLLVSQLTHPFKIVEIRPVPERIVSNLLSNFTYDESPGGTSLEDSVNKNITLEDIFISVKTSRHYQTSRLPVILKTWFQLAKEQTWFFTDVDNPLHQNQTNGHMINTHCPSYHQPKHLCCKTSMEYDHFLDSGKKWFCHFDDDNYVNIPRLVAVLQRYDHRLDWYLGRQSVNRPVYVNYQKKKILYFRFGTGGAGYCISRSLALKMSPIASGGRFMSVCEGIRMPDDVAIGFIIEQLLKVNITEVPEFHSHLEQMKLLPLNKLRDQISFGFFWKKNYKDTINAVNVPGFNARYDPTRFLSLHCFLFPYFQFCKLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7I3</accession>
    <name>A0A835L7I3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7I3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032744530" evidence="2">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="198" mass="22711" checksum="551E4313ADD584BF" modified="2021-09-29" version="1">MKLLISLILTAGVASVIANPVTLVTQEENINIANEPSLTETSVSEINTQDATVPKSDPEPTKVEIVTEELVPEPNIVEEVPKFDNGEVDIVIEESVTPLEVVADEQNEVKIDADDYLHPGDQLIDNILAERIKDEIMDTAEGFAPLPLQLRKKHRQPARRRFAIRRRYPAYPYPYTPYRRISYYNPYYYYRPSSLRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L860</accession>
    <name>A0A835L860_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L860"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20130" checksum="E49FE20F251A0443" modified="2021-09-29" version="1">MSSSYAADNKETFVKRYCKASKSKVDVKCPMIISEYNQLMGGVDLAGMRHCKMLNEKKVMSLKDFKLSISFTLLQKGKTVSRMATNSVKIKQPVVPRPEKDIRTDGLHHIPGIVKKGRCRNCTTGQTVISCLKCNTRLCLMEKQPLIIPTWEGGNMILGSSCPYRKDHLGHWGVQDDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8V5</accession>
    <name>A0A835L8V5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8V5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="393" mass="43956" checksum="39EFE44AACD2BF6A" modified="2021-09-29" version="1">MYGKAETKPIRGPFIYHMALPSIANFDKNSSDEDSSGFNDSSESELSDDNANAEKNKPRDHPPTIICEDFIVDISLHPSKNLVAIANIVGDVLLHEYNNDETKLLNTLELHLKACRDIEFDNEGTTLYSTAKDKTIMATDVESGKLKRCYENAHDEPVYRLVNLDNNKIVTGDDGGTVKLWDMRKPDPIFSIKIGEEHVSDMITNDAQKYLVCASGDGILTSIDLKGSKIFTTSEEYDSELTCLGLFRSDTKLLVASSIGKLYLFNWKEFGLHSDEYIGQKHAIQCMVPITQNIVVTSGEDGVLRAAHMFPQRQLGVVGQHRLPVERLDISHDGQYIASCSHDNDVKFWNISYFESIDSIIDVNHKQNKRRDLSNNLPSSSIKNAADFFSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Y2</accession>
    <name>A0A835L8Y2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Y2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="303"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="347" mass="39106" checksum="62EA72EBB9637138" modified="2021-09-29" version="1">MVKIAVLGAGINGLTCAVKIKEKYKDYDVVLISSEFTPNTTGDGSGGLWYPFICGATPADLIRKWGSETYKYLHELYRTGGHGVSLLPVYSLYRTKEKFNKPSWWDIVYGYHVLDEQQLKDCNELFSDKYEAGHTFLTFASSAQKLLAYLQERFERANGRLLRAKITSLQDPLLEAYDVVVNCTGLGARWLVPDDAVVPVRGQITKVKAPWMNLSIIDEEGGNYIIPNSETCVLGGTHQTDYSTEVDAADTEFIMNGCKKMMPGLRNAEVVSHWVGLRPARNSIRLEPEEKNGKLYIHNYGHGGSGFTLFWGCGDEVLQILQRHLDRNQQKNQILSKLKKHLSNYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Z0</accession>
    <name>A0A835L8Z0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Z0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF19">
        <property type="entry name" value="USP6 N-TERMINAL-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="99"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="567" mass="64667" checksum="4BC72A6C2DB2E0D9" modified="2021-09-29" version="1">MNEEALLARASEERERIFQRYERGRENLIGQIDPWEDPEFEDYHKTDRYGFIHDERLPQKTGPQKVNIEVEREKKWVKMLTHWDSPATKEKLHRRIYKGIPNSLRIKVWCKLMDVNKIKSANPGKFQEMLKLAKLWSTDVRQIDSDVNRQFREHQFYRERYSEKQCSLFNVLCAYSMYNSEVGYCQGMSGLAGVLLMYMDEEDAFWALAVLLSDKNAILYSLKWFFVCFVERVPFSLCLRVWDIYLLDGERVVTAMAYTILKLHKKAIMKLNDMDLIVKLHKDFGFEDDMVIYHLERSMEELKRAKLDYPGPPPPNELPKRQLGLFVEPDKKSKIGQRAENFSETEKQARATVILRREKAAIELQELRVSQSDTVSEHSGVAGGIRCDDSVSALGSRRSLADTSVTSTADLSVFSSGRSHAMDNSLDTHSNVSDDATGSDGSGICGLSIQRAPSTAHSTPRATPHPPSVSPMSDDVVRIHVTYNPRAGSPHLHPISPSKYKAYNNEEHHKPVSLGFYTSNGSTNLPSDNRIRIQVPSESEELLTPVVDAGNNITPRFIESHTEMYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L974</accession>
    <name>A0A835L974_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="16">DHOdehase</shortName>
            <ecNumber evidence="4 16">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_001137</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="16">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion inner membrane</location>
            <topology evidence="1 16">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 16"/>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L974"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000066">
        <property type="entry name" value="Dihydroorotate dehydrogenase (quinone), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 16" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="78"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9423582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="393" mass="43117" checksum="98305C352B65E0C3" modified="2021-09-29" version="1">MASKKQAISKLKSLCTVTLGGAVAYQLIYYTKDFNGYYVNVLQPVIQYLSPELAHNLGVKAIKYGIFPPEKGDDPQVLKTKFLNYDLSNPLGIAAGFDKHGDAVIGLRNLGFSIVEIGSVTPKAQPGNPKPRVFRLPEDEAVINRYGFNSEGHEQVYKKIGMIEKALLDKGLLGINLGKNKLSENPIEDYILGIQKFSDVADYFVINISSPNTPGLRSLQKKEELYQLLKNINEARNSINSKNKPPLLLKLAPDLSHNEMKEIVSVILQNESKVDGLIISNTTIERHQLQNTEFSNETGGLSGKPLANKSTEMIKQMYKLTKGKVPIIGVGGVFTGQDAYDKILAGASAVQIYTALIYHGPPVVSKIKNELAELLQRDGYKSVNEAVGKGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9D0</accession>
    <name>A0A835L9D0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9D0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="148"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="586" mass="67753" checksum="5D977A35841B63FE" modified="2021-09-29" version="1">MANRKTLNVNQIISHLEEDDDVFAADIFITPPDNWQNSDEDSGDEEFASINNLSRHQLLAEAELRVTRSSQPESRIVNELVGDEETVHSIPSTSSVSQPPQPISSLTVTQPPPKRRRVEVTRKWRFVDIPEKSEKEYCEPDFLENLENPVQFFELFFDEEVFELLRSETEKNAIQKGKHAFRITTTDIKHFIAILLLSGYNSVSRYRMYWEQRVDCSFPTVAALMSRNRFEDLLRYFHVADNNNLDPSDKFAKVRPLWKLLNARWVKYYPGDKNLSIDESMIPYYGKHGTKQHIHGKPIRFGYKSWSICTRLGYLIYGELYQGASTGNTHPELGVGASVVLDLISKLPQGSYSFYFDNFFTSLPLLEELQKMGHDGTGTIRANRTEKAPLKDPKEMKKTSRGSHHQCTDILSNITLVRYNDNNIVTVASTQCGSEPISKVKRYCDKQKKDVDQPRCFVNYNKFMGGVDRLDQNVGCYRIAIRLKRWYWQLLMFPLNVSVNNAFQLYKISPAAKKSNEILRYLKKVILNEERCTARRGCKPDIISLLDNYARLQIKTFGEQYSRGWKRREKKLSSPRFTTDVDLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9L1</accession>
    <name>A0A835L9L1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_013355</name>
        <name evidence="7" type="ORF">HW555_002333</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000432">
        <property type="protein sequence ID" value="KAH9637869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9L1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9421893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9637869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="156" mass="17674" checksum="22F4BC0397FEF051" modified="2021-09-29" version="1">MRGLQEELDKSQLQLLQNAFDAFDHEKKGVISTDMIGTILEMLGHELDEDTLKEIITEVDVNGTGELQFSDFCALAAKFLQEEEDDEAMLKELREAFRLYDKEGNGYITTDVLKEIFKELDNTITAEDLDTMIDEIDSDGSGTVDFDEFLEVMTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCL7</accession>
    <name>A0A835LCL7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YegS/DAGK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_000945</name>
        <name evidence="2" type="ORF">HW555_004036</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000386">
        <property type="protein sequence ID" value="KAH9638544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCL7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF112">
        <property type="entry name" value="LD11247P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YegS/DAGK C-terminal" evidence="1">
        <location>
            <begin position="216"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9638544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="325" mass="36018" checksum="BE527A8DC906C35D" modified="2021-09-29" version="1">MNQRFRILSEPYIPQNLTGLTMGIVKGETAPMDVVRIETKSSIMFSFLSIGWGLLSDIDIESERLRAIGGQRFAVWALARLVGLRKYKGVVSYAKIKDVSNLPKPKQPLTLSHSISQDGALDSPDAEAFIDADEHSEVFVNAISGKQHQRVDSWYSVNSRRSAFYSTRGSEYHSVTSSGSEMRSPVHACMHGPASHLPSLMSQLPAHWVHEHGEFVMVHVSYQPYIGEDFLFAPRSQLADGVMWMLIIKAGISRSQLLSFLMGVGQGTHADINNEYIKMVPVSAFRIVPEGTTGNITVDGEIVEYGPIQAEIFPNIINVLVPEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEH4</accession>
    <name>A0A835LEH4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEH4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="246"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="443" mass="49330" checksum="028E89F15C73FA9E" modified="2021-09-29" version="1">MESEKEASQVREVSLVKPNYMLMSLQRIFVLTVIIVGVLVVVHYTPMPEEYFENCDRECHELDWPMICRVKLVIEVYKTLSKSCGSCTEKDGGECPATCISADGRERGVLVANRALPAPTLHVCENDILVVDVVHRAPAHALSIHWRGQPQKETPFMDGAPMLTQCPQPAYTTFQYKFRASAVGTHMYHAHSAADAADGLAGAFVVRQSPRLDPLKKLYDVDATEHTIFVSEWGHSMGPLAGVVSRIPNAESLLINGRGKSSESPDSPQSSFKVEYGKRYRFRLAYGGGSKSCPIKFSVDHHTLEVVTLDGHQIEMERVNSIEIGRGERADFILEAKRVPGIYKIRVAAVKSCQDNLEGEANLVYDNKGQKVLHKDDDVVDAQVYRELTTVSSERCDLDNVICLHEIHSANKLPAELAENLDKTIYVPFNYSTRQISAKRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFN1</accession>
    <name>A0A835LFN1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_016830</name>
        <name evidence="18" type="ORF">HW555_001063</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000942">
        <property type="protein sequence ID" value="KAH9627676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFN1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000198">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000355">
        <property type="entry name" value="Toll-like receptor Tollo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF385">
        <property type="entry name" value="GH01279P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033048006" description="TIR domain-containing protein" evidence="16">
        <location>
            <begin position="22"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="17">
        <location>
            <begin position="1068"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1237"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9423508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9627676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1273" mass="144934" checksum="7E32780BC2008DF6" modified="2021-09-29" version="1">MYLTRFTCALLVLTTSVTVRGASLSAGTRYQAPDECGWMTDYDGSGVALQCRLRTINSELENTNFSAIQPHPTVRLRLECSDALFFQSSLAPGSFRQLIELRELTIEYCKIGNLSDSAFTGLRELRNLTIRTHNTDWSTMSLEITPSAFSRDVQNLERLDLSENNMLVFPEGALCTLRNLEYLNMTGNRMRDISHFQFSSAHRHPTEKCGDNLLVLDLSRNVIDTLPPNLLSGLRRLQKLYFQGNGLNSIADRALEGLISLTTIRFSDNQLTSLPPELFSDTKELKEIYLNNNTITVLAPGLFSDLTQLLVLDLSYNELTSDWINTSTFSGLKRLVYLDFSHNRVSKMEIALFRDLHNLQTLKMQDNFIEHIPENVFSSLSNLDTLTLSNNRLTNIESYAFMGLRVLSVLSIDSNRISKIHPHALRNCTSLQDLHINGNRLDEVPLALKEIPQLKTLDLGENLIVSIENASFMTMEQMYGLRLTENNIGNISKGVFDKMTSLKILNLSRNKIHKIEAGAFDANVNLQAIRLDGNYLTDIGGLFAKLPNLVWLNISDNRLEWFDYAMIPTGLQWLDIHANRIAELGNYFEIESQLSLSTFDASSNKLTEITGSAIPNSVEMLYLNDNLISKVQSYTFFKKPNLTRVDLYGNRITSLDPNSLRISAVPQDKTVPEFFIGGNPLECDCTMDWLQKINTGNRARTQPKLMDLDSINCKLLYSRGNAQVALIEAAPHQFLCKYESHCHALCHCCDFDACDCEMTCPNNCTCYHDPSWSANVVDCANSAYVNMLPEKIPMEATELYLDGNDIKVLPSHAFIGRKKLKILFLNASNIETIHNRTFNGLKELEILHLDFNIISNLEGQEFDGLDNLRELYINNNKIKRIGKEMFNHMARLKVLHLHHNRLITLSVWQINPAITEITLSFNPWSCDCEYTEMFREWTKRVSSITDLSDIKCIYSKGNSTELTVYNESMYSDPDSGFKITSENGTLCTGLPSINNSINGNLTATRTIITNEEVPDYIPLLVATLGCFLIVSLVSMIIFIFRQEMRVWFHSKFGVRLFYRATDREDSEKMYDAFLCYSSKDEVWVTEELASMLERGDPSYKLCLYYRDLSAHVTEKIRQAVESSRRTIMVLSENFLRCEWVRYELKSALHQVLRDRRKRLIVVLLGQVPQKDLDPDIRLYLKTNKCLHADDRLFWEKLKFALPDVRDNPRCRGVPSPVVSGGLPMHRHHHARNHLGMLPQPPVHGAHPVLPPHPSHTSHQVPPRASPRTMSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG36</accession>
    <name>A0A835LG36_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG36"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="2">
        <location>
            <begin position="353"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="544" mass="61564" checksum="100BE5C155C00CBC" modified="2021-09-29" version="1">MDTPGEYEESDFPIWQEPRCEPLGAPKETLCDENNSDQAHGDRLHALEEEQEILSSSVFSLTSHLAQVEFRLRQILKAPPDEKDEMLKALEEFTSRGVHDSRAAPQGSSGDASCTECVELERKISRQRTKQAHFIDRLKVQLKELERFAANPTSTCDSKHRTLIDHLRTEIDQNLEEGCHQPLTAEELRHQINCAVRQYADRQLSKDEIISKLQAHIEDMQKFIKLMKNEELKNTKVTSEAKNVGKSEKFDKTFSKSKSNDDLRAETINLMRKASTLIQIFTVSQFGCSPNTNRRHEGKSSTIVTHWGNLRARLEMSVDGVLHLVSRDRPSHNMVDSYDSESEEGGIVINDAPLTTAVRRHLAINLRDLLHHGLTGPESTSLVPIIGCFPVRRSSSSRATHIWEVILRYYDLNDGDRFNSTPARKLSQSFNLDIVGGTAITNKQSLLSVIGSIVASHTPYKRSYDAHFKAFVCAALNAHKLVIWLNIILKSRSLIDAYYSSTSYVVNTGFQDALQSLDRLTPYNFDLPVDLAVKQFQNIKDVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7T1FUP8</accession>
    <name>A0A7T1FUP8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BOK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007202</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MT648760">
        <property type="protein sequence ID" value="QPM99235.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7T1FUP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF48">
        <property type="entry name" value="BCL-2-RELATED OVARIAN KILLER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="8">
        <location>
            <begin position="133"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QPM99235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="291" mass="31806" checksum="F992A9994A4ACE76" modified="2021-06-02" version="1">MRRKLSTPLSAMPGVTDGLINLPNLRASPSRSLSPLDRTKRRFSTMVSSSAAAAVSRRLSATIGWCLASPTQVKPQIVRQGRALCIQYIKTQIRRSTLCAKKQIVIKRLQRMLETECGEEAVSNSESGVLVGLRALCAALERKRPDAFRQVARQATRAPSAMLRSDTALAELALALARRITRENITWSKIAAVYCVCGALAREAAEAADGEPALELVSAPAAAIADLLHEEPGSWIASHGGWNGLVERLLASERDQRSEKNLRVLVSFFVLACLSLLLFRWVLHAHPAYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0I5</accession>
    <name>A0A835G0I5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000786">
        <property type="protein sequence ID" value="KAF9405203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0I5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF237">
        <property type="entry name" value="PICKPOCKET 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9405203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64626" checksum="BEC76ED9F9795450" modified="2021-09-29" version="1">MVQINSEVSHRRSRRVVYNNNWNKKKLQKNFCANKFVEFCKRTDLHGYKYIVMEDFNYGERCCWALAVVTSIAIAAYFVVTAYNWYARNPIVTVIESTQGAIWDVPFPAVTICDLNIVSKKAARNIAGNLTLPDNITEEYVFEAFRLVPLLYSTFSANEKEKEQLRNLQAILDLNNMPIDILFKELSPATSCGNLVQQCMWKNSIYSCDEMFKQIYTLLSLCCTFNYFAVDDIEDELMTDKRPLMTPRRVASCGYQTALTVLLYTNPEDYYSATIASQGALVIIDNAYNIPDLDSPVRMVNPSTELLIALSPERTYTTSGIRAFTPDQRQCYYSDEIKLGNFRQYSFHNCMAYKKVSMLKKHCNCIPLSFPKEESYRFCNFDDMDCLDQILNEAEDSNVTKELESKITCYPECEHYDYPLEVALGNLADSTYVNGLLFFDDVELKNRSLLNVFFNDLVSTRYRRDVYLNWQNILAAFGGLLSLMLGFTLISGFDLILFFTVRVAYDFCTTIARKPQTNKIYVNDFNSRKKWMDNTIPDLVNRKPTDNTKNDFLDRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1G2</accession>
    <name>A0A835G1G2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_004965</name>
        <name evidence="4" type="ORF">HW555_013483</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:36435"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000655">
        <property type="protein sequence ID" value="KAF9405982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000894">
        <property type="protein sequence ID" value="KAH9628805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1G2"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9628805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="9284" checksum="A8C1FFA35B6EFA47" modified="2021-09-29" version="1">MNSIGEECTELKKKYDDCFNSWFSERFLKGDHDDSICAGIFKVYQDCVKNAMKQQNIDFKEIDKDVLGTESEYKAPPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1I2</accession>
    <name>A0A835G1I2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_014352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000995">
        <property type="protein sequence ID" value="KAF9404400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1I2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000001">
        <property type="entry name" value="Preprotein translocase subunit SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00303">
        <property type="entry name" value="SECYTRNLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9404400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="378" mass="41321" checksum="5A85FDC58273B16E" modified="2021-09-29" version="1">MLNMVSGSAMQNFSIFSMGVSPYITASIIIQLLQMDIVPKFVEWSKQGEVGRKKLNQATRYLTIVLGIAQSMGITAGFQQLSSVGVVENPSIRTFIMIAIILTGGTMFVTWLGEQITEKGIGNGVSMIIFAGIISRLPEGIKEIVDDYFINIESSRIWQSVIFIAVLIIAILVIVTLVTFFQQAERKIPIQYTKRVSGAPTSSYLPLKVNAAGVIPVIFASSLIATPNAVLQAFSKSYSGEGWYDIMTQIFSYNTVPGAIIYTVLIVAFTFFYAFVQVNPEKLAENLQKQGSYIPSVRPGKGTEEYISGMLMRLSVVGSIFLGLVALLPIIAQMIWKLPQSIGLGGTSLLIVIGVALETAKQLEGLMLKRQYVGFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1Q5</accession>
    <name>A0A835G1Q5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1Q5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="247" mass="28525" checksum="C1A5D9FC38E22B16" modified="2021-09-29" version="1">MKTKLFVRRQWIYPLKSHLLSPYLNPVTRGQQKYNDAHIKTRNVVERQYGVLKRRFPVLAVSIRLRLDTAIRVMLACCVLHNICIIRKECEPINDGSIPNLETLINDDQIPRPPITNSDPVYGFQRSQMTQYFDNGVTRIEYVSDDRKHTGSGAARPAKTCSYVLTATAVMLRPPNKTSDIKYRSRRRNQMCNINRKFRLIGIGVGAPRYIRNAYFSYLCVVDVELMEFVMDIHALFFASFVDPSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2B1</accession>
    <name>A0A835G2B1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000561">
        <property type="protein sequence ID" value="KAF9406678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2B1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20528" checksum="2BFCE89BC2483F1D" modified="2021-09-29" version="1">MYSITMSSRKTAGRRGTNKKRAQRATSNVFAMFDQAQIAEFKEAFNMIDQNRDGFVDKDDLHDMLASLGKNPTEDYLEGMMNEAPGPINFTMFLTLFGERLQGTDPEDVIKNAFGCFDEENQGVINEERLRELLTTMGDRFTDDDVDEMLREAPIRDGLFDYVEFTRILKHGAKDKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2H7</accession>
    <name>A0A835G2H7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000546">
        <property type="protein sequence ID" value="KAF9406812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2H7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="137" mass="15934" checksum="AC8AA9013EDE617B" modified="2021-09-29" version="1" fragment="single">YLYLRTNMRAHLHGNTHSNFPQQLLKLGEGTFPFLNLDTNYAITLDEKTYIKITLGQMIHYLDSLIDAIYPDIENLHKNNFRWLCCRLINAINNLIMQKVPGEVKCYKPSLTSRTPSLTSRTPSLTSRTQYTIPRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G338</accession>
    <name>A0A835G338_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPF0547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0547 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000630">
        <property type="protein sequence ID" value="KAF9406176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G338"/>
    <dbReference type="OrthoDB" id="5981040at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040246">
        <property type="entry name" value="C16orf87-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018886">
        <property type="entry name" value="UPF0547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31101">
        <property type="entry name" value="UPF0547 PROTEIN C16ORF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10571">
        <property type="entry name" value="UPF0547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0547" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="159" mass="18399" checksum="B2B986CCCCB8AD9E" modified="2021-09-29" version="1">MGKHKMIAKSCPKCELQVAVASKSCKCGHTFFAARRGADCLPAVEDIRRRTGRVRRSQPQFYDAQHYQKQIKRRSPKKRSLSRSMDEDTKPKDKNESARARRRRALRRAQRPPPGNNNGERTRDPTPQLRPPQLARCRLILQEINRKISSVTWQPPADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3L1</accession>
    <name>A0A835G3L1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000447">
        <property type="protein sequence ID" value="KAF9407668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3L1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28587" checksum="EFEF3BF10A3F59B5" modified="2021-09-29" version="1">MKIEMQSQTTELKQSITKSIMDKIDEKLIPLVEENKNLKNKVEKLEKEVEVMKRAEKKNNIVVFGLEEKETSTLELLKEFKKHLNQDLNIKIEDYEINKIYRLGTKNRENNKPRPVLCSFVSNWRKNEIIKNKKSLIKINISEDYSKEVLEKRKALQAKLAEEKKKGNVAYLKYDKLVVIEGKINQDKRKREASTSPTAYHPLSPSNQHKKQQIIASIKANRTNVFDMMRNRSNSLSNISTTGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3M8</accession>
    <name>A0A835G3M8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidoglycan recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000786">
        <property type="protein sequence ID" value="KAF9405202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3M8"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="8">
        <location>
            <begin position="273"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="287"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="50466" checksum="AF91A25D74415F80" modified="2021-09-29" version="1">MALKNQSGYVDDNIGIKVEGELGDFQIIEENSDSDGDIEIDSKSSRTTGAVATIPSIPPSLVKPNSSPIQGNVAVSNSENVVIGNHTYFNGPVIIKQVIQNAPGLENPSYVKTDDEDIPTQKYERETKNDKTIKKFHLRKWHKITFSAVCVVILGGIFAILSIILSNSTQDDISSSSPTSEEDNTSGTPNYTKVVGLFYENLNLIIFTIILMPLTFLLMFYTLLTLDDSGDKSVVTPIERHRKKRDYEAIEDDSDPYVKPIKANPLLIAPDHLRIVPRSDWLAQPVENELDKIRQPVPWVIISHTATESCKTQSECVLRVRLIQMFHIESRKWDDIGYNFLVAGDGSAYFGRGWDYVGAHTLGYNRYSIGISFIGTFNNDPPPQNQIDACIKLLKRGVEIGKLAKDYKLFAHRQLASTLSPGDKLYDIIKEWPHFVKNFTNPSELLPKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3Z2</accession>
    <name>A0A835G3Z2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_012925</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000541">
        <property type="protein sequence ID" value="KAF9406846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3Z2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9406846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="28263" checksum="CFB0F113F915C111" modified="2021-09-29" version="1">MVQCAVYGCSSRSDVYNYEKKEAIQLHRIPKNPRMRSKWIQALGKDNIKESTRICSLHFDEKNYYTTKQGLRRLLPEAFPDTKLPDPPSVESSESSDDEEQAPNIVILNQIPAVNTIVSNISHSVPTKIIVVPQSSTLRIEPQIVNQVNLAPVNVVGTTSPYVQMQAQASENTSRTASAEGNFENQMTTPLEKKLMIEVKLLREAVDCLEEQNRRLLTKNNFLQQKLNNYERERGMVNIVDFKPDNFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G419</accession>
    <name>A0A835G419_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small G protein signaling modulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUTBC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000411">
        <property type="protein sequence ID" value="KAF9408051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G419"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15784">
        <property type="entry name" value="PH_RUTBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000004">
        <property type="entry name" value="Small G protein signaling modulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000064">
        <property type="entry name" value="Small G protein-signaling modulator 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037745">
        <property type="entry name" value="SGSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="462"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="110882" checksum="7A4D7230167A0AB4" modified="2021-09-29" version="1">MQVHLWIRIALFERQLAKIIEHLVNNANRYYERDALVADPDYGSILSSLLVGPCALEYSKAKAPACFWTDPPADELVQRHRMSAGTTTPPSVRRPILNFKRSLNASSDDGASSNTGTGKAAGSSAKDYVESLHQNSTATLLYGKNNVRVQPKDVEEPMPGYLSLHQTAAGLVIKWTPNQLMNGYAESEGIDKSVYWAMSLQVCVWEVVYVHVHWSQASDALILVGQDGVQRPPIHFPKGGHLLSFLSNLETGLLPHGQLDPPLWSQRGTGKVFGRGKARRRPLPSLCESGETEEPEWEETAGDYVFRIVNNAIADREAMRHSLLERAVQSPPRTPRRPLASTSTTSSDSSTMSVDCPPSAGINGHPPLTPIPHQPVEQAASIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHPIIVPRENAEGGLTDERWLAMTDESGAVHDKDEVYRLVYYGGVQHDIRRHVWPYLLGYYEFGSTAEERAEQDAACRRQYETTMSEWLCVEAIVRQRDREATAASIARLTEASGKLKPTDNNDTSEVFEDDCSVISDNPPIVSPEPSENEQRRPDKPVLSRAPSIDEVDNIEMDSERDKETKQNGETENGDNRDVDVDSLKDLDEDVHLKSVVDNPDMRRESIAEIKRLAEEIVQKGDGRGLLCSVDSAHVNGTGSDFRSSIDESQPSPHQQHTSVIITNPSVDLAAGGSPASGGTTAQVSPARSPLGVVREESQSAGASFDTLEPADRNAQDNRSNCVSPASSNGGVYSNELVESFALNLHRIEKDVQRCDRNYPFFTDENLDKLRNIMCTYVWEHLETGYMQGMCDLAAPLLVMMREEAHAHALFNSLMRRATDNFPSGQAMDAHFADMRSLIQILDCELYELMHAHGDYTHFYFCYRWFLLDFKRELLYQDVFAAWELIWAARHVASEHMVLFIALALLETYRDVILANTMDFTDIIKFFNEMAERHDASAVLSLARDLVLQVQTLIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4A6</accession>
    <name>A0A835G4A6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_015202</name>
        <name evidence="2" type="ORF">HW555_012910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000535">
        <property type="protein sequence ID" value="KAF9406875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000010">
        <property type="protein sequence ID" value="KAH9645842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4A6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9645842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="550" mass="61927" checksum="881FA81D7A0DADE1" modified="2021-09-29" version="1" fragment="single">MPVVSPSRYSTTSSSLSGSYRSTLTSSTVEKPYYRSTSENYGTIRSYEKSEYRSRFSDLDGNRERKTIVERSRTSRAPSIADSDSGISSRYRSERSESRSRDISTTRSESSKTSSDTIGRRRPVIPSADLAMSHADWYNKYSPANYIPLTQRIQQQQQLNQNFGEISRSKSISNDIGRPPVSDPTRLARKARNSAATISERPERRSYKESSPVYKRGMLNGVKDTNGNEVPSVSEIRKRFDPKMTVTKLPANDSRYTEQYLNQLKDCENGTVGYTKVVPKDEKPVPVHLPYEKNGLRWEIGSSSSRSNSNSDLSLSKTISEPVCLAKPIHDRNSSMSTSLTSKLPSDRLASIKSQLDPNNPIGKILEKSTVIHVENGDLDYKKNNSDGSKIKDIKSDIEKQTKTPKHTSNFASYIQISQPVASGTTPKKQIDLNHTVTEESPKNDVKAEPRKRASLKYIDSEDDRILLDNDIESPSGTGFENKTFEHENYLKKRTEKNEEGKENLEEIKSMETSTESTISEPTDDNNMSPDTPSSRRRVLDTKDYDDIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5E1</accession>
    <name>A0A835G5E1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_013287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000613">
        <property type="protein sequence ID" value="KAF9406283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="278"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="468"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9406283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="656" mass="74227" checksum="96805867F3789AB8" modified="2021-09-29" version="1">MCIKVFISKITRGGNIKFTMSQHELSCGLEFTSTPDLQACLSESLRSNYSFVVSPIVHPRFGDHVQVKVGGFTRSDMILSPNDWTSRMVGRLSPYLNVDSLFRDRLGLPAIMLSVHGRESNNLTRILNTYFDSSHHPSLIWARVPMLCTKTMKDCVNEGDEAAPFNEPWLWWSKFHERLEFDKPLELSADLPPEDVIKRWLGEPVKVVIVPTSIFYNNKKGFPVLSRPHQQLVVSLIEHEAQVLVTGARRSNVEYYLQFLYRIWKRRPYFGDDPMLSYARGWEDYLQTPLQPLADNLDTHTYNVFEKDPIKYDQYQKAIAQALTDLQKGPSNVINTDISTANAQEVGQGDNADSKKKTYTVMVLGAGRGPLVRATLNAADITNSKVKVVAVEKNPCAVVVLAAQVREVWRDRDVVVVPGDMRQINLSPKADIIVSELLGSWGDNELSPECLDGAAGLLKPGGISIPCQYRSYVAPISSPRLWAAAKVASSVAQSNHKDKNLETLWVVYMQNKHDIAETKLVFTFDHPAKGARDHEGQEMVDYRGLPETDNRRQEIITWEVQQDNVMHGFGGYFDCTLYGKEMISIVPSTHSPGMISWFPVFIPIKTPLRVHKGETITARFWRCTDARKVWYEWIVEVGNRSTTLHNPNGRSSEMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6J9</accession>
    <name>A0A835G6J9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000459">
        <property type="protein sequence ID" value="KAF9407557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6J9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="25851" checksum="54FD98F8F0DD333E" modified="2021-09-29" version="1">MLVEACSAVLYGAVFLSLILIDFILGHGFVDMFQKIFCKIACFVKKTVREEAKNVTALPENPISLPVLFVEIFALSLTIAFLNKYKQFRSKDRFDDLLLESKEALRQTNEFLEKWRLRRVPTEYSYLDEEPQEIKPLKLEVPILHMAIIDTLGTTRSQPERGDAGDTVNIMDSTLLSVTSLLDDDLDSIPDPLPSEEKIIEETKNIEFSNRTLWDVMEEDANSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G742</accession>
    <name>A0A835G742_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Yellow-b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000331">
        <property type="protein sequence ID" value="KAF9409185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G742"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF12">
        <property type="entry name" value="LD43175P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41982" checksum="34CFC01003C2B667" modified="2021-09-29" version="1">MNNSTTSPKLIPYPSWAAHSIGEDGKPPEIISPFRVRADRCGRLWVLDNGKMGNLEKNTTKYPPSIIVYDLKTDNLLRKYVFPEDQVKEDSGFANIAVEDIDCENTYAYAGDLGKPAIVVYSWEKNESWRITHHYFHPDPLACDFSVKGFNFSWTDALFGMGLSAPNAENYSTLYFHPMASYDEFSVSTKFLRNKTLADDNFSAFNVLGSRGPNAQSSVSFVDQKTGVLFYSLVNLNAVACWKTSNKEYLMKNQGRIYMNEETMVYPTDIKVDYNDNLWILSNKMPIWMYGKLDENEVNFRIFSAPVVDAISHTACDITPRSDILDKFVNKIKNATNTIVAKIKPNSGNVAYNPLAVVSILMFSWIFTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7A1</accession>
    <name>A0A835G7A1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7A1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="10996" checksum="27A7C650E4C93993" modified="2021-09-29" version="1">MPSLLITTLKFCRSQTIIRNVFDPSAHLYRLVPLLLVHPHLHQVLQAPVMLQKLVRIHKLFSKERVEIRTACLIIIFPLFTQMKVTLISATMILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7E3</accession>
    <name>A0A835G7E3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000358">
        <property type="protein sequence ID" value="KAF9408834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7E3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11697" checksum="66ECF0CA3A41C63E" modified="2021-09-29" version="1">MPRRSLIIIYGEARYNWEHSVLREDIASRRGNLPPPYLNGDQQEIGNTIRKIGQNFWDHKGKKYNSIEPQIPNDKMGVMDIIKSPGISPLIGQNKKVENQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7W1</accession>
    <name>A0A835G7W1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000423">
        <property type="protein sequence ID" value="KAF9407912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7W1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="465" mass="52701" checksum="AB3BBED920C0868B" modified="2021-09-29" version="1">MHLNVILSQIETEQSAPLEVIAPAMEQIFMIEVFVKKIILKIEPPEKDEYELQMQEEERRKEAERLAALEAAQKTKKGKKGKKGGGKKGKKGKKGKKGKEPPAPSEEELKYMQTCTMQMNCLPLFDFYVAHDNFVAPPPPPPPPKKGKKGKKPKKKGKKGKKGAKIMPIKLPLPSEPLPQPPFFGVGNSVIFLSRPSKLEEVLKKTPIYVTVWNRDENMGCTGFCVVEWHKSFFECLEKAEELNPANYDQATFRDTSKPEMVTNTVEMIRPLQCEEDLKASGEIEFYLRLTCLGNRVVSSFIALPEMDRIPGRKYLCDDLKLKDIEVVRHWDGTMIDEVPPVAYFFSAPDITREPIKPVEEIVEYEEFVAPFTQSELAILSMGFPKGPCGGTNCPKRMEYRGSQHQFIPGEMVKGKYQHGQFVNKRDVHGPCGRLDCPLAKKVRAYLCSDGSYKPCKKPCCKDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G800</accession>
    <name>A0A835G800_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G800"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="209" mass="23378" checksum="9866093E9DD23ACC" modified="2021-09-29" version="1">MMSHTSINLVSRISQEVNPPVSFEGYFSRRGFSSSIDTILWRLPSEALIMITPSCDQQERIPKCCRALVKMDCLVFVRNSLTEILVPLKPPINVQHALGDLLSEQTQDTVDKLPECPELLRNLCYSFLGWSCSLNLGSKLLVDRIESESVDGDMAGGVKHSIRLHLSFLIQRAYYELIVALLEGIGKTIKDHNIRGITSAMIAFLEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G819</accession>
    <name>A0A835G819_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000322">
        <property type="protein sequence ID" value="KAF9409379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G819"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="445" mass="51044" checksum="6D55E1EA96FECE6A" modified="2021-09-29" version="1">MAYPIKYLSLQKSELEYEVAVRGETPANTVAELRRQICKLSQVFLSEDILCSHLDPLDDLNSCLEILNKIKDSLEVDTPDKNVLGRIENLFHHLYHRLNRICRDDKFMDVHTECTNMFREYYEALSSLKARSIDPLISIPHSDAQVKPEKLNISVTCEGNVKSSELAKLKYDGKSCVRAFIQRVSEFSVARNITNAKLLSFATEIFVDDALHWFRSVKHQVSSWEELVVLLQQDFDKADYDYLLLSEIRSRTQGAKENITIYLSIISGMFSRLSRSLVEEDKLEIILHNIRPCYASTLASASQITSIDQLRMICRNYENVQSRMAQFREPSAATSDTLAPEFAYKQRTDLASKQNYNNNHKLEFNKTNSNNSKQNFNNNVNEKYLHALNTDSAPGGKLPYCPRCRNNSHSLRDCQNKEIMCFKCGQKGVKKPDCPNCNKVQIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G897</accession>
    <name>A0A835G897_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000316">
        <property type="protein sequence ID" value="KAF9409472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G897"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="241" mass="27476" checksum="6B547B2D446288B9" modified="2021-09-29" version="1" fragment="single">MFKFMRIFLHVKPLKSDDMIRSPSTFHCLSQQRTIASSHTDAIRIMQVMSYTRLSYASQETMNYAVISDNRTRAVLSAGTALVLASRNIIQQQVGRGTKQGIITNENKVTKKAKLNEGASTSSIETNDIDNNKVECDTCHVYIAKRYLNNHLKSNTHKNNLLKLHNSLPNVTVVETAFGNRILTYRINSKTHQSGQYFETPESFLNSLKIDILFLINECIQQHTILKINFILHADFIQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Q8</accession>
    <name>A0A835G8Q8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000300">
        <property type="protein sequence ID" value="KAF9409755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Q8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="850" mass="92266" checksum="9B8F92AAC0622BD6" modified="2021-09-29" version="1">MIGHSESKGAKKREKSAGGNGNGKPSRGVATSFGFRRRPASTSRADDNTRRKQKAHDKNGNGGSTEDLRPEEVLSGRSTPLARPRKETPGQPLRSTRFGFRQQHAKTAKVGDVSVAAEQAFGAPQKDKETAINNNALDKKTPGYNQLPLQATQVSATGVTTIVGAGGVPKTHTKQTVILTYQTQQLPAQDVRPTKSVRISEPASRGASVPRVQPEPQRAPGKYTFQTTQLPRPQYPAVKHIDAKATKQVVNNTRKSGVTDGWREGAASAVSSDSGVWTGGEGGGDASPRMRRRPRNLEMVMRNSHCFHLRELQVSDLDIMDDALITGQAVIPLPKLPSTFDDELTPEYEVTPAPTYKPPSPILPKPVPASELSQKQNSPMSTLDRYRNRNRPSLIQTNLDEEKFVLDRAQPEKLNKQNSFVKSSSGVVSPTTVNSSKESSPSCKSEESHFGNSGAWQSHAAGEAMATSCEDDKSKLDNKEPPKVEPEIPKKTIVIVDEPPPPHPLLMKSLTMSQHDALRATMMGSMTSSNYSTTSTCTNQSGDHHNLTLTLEDSKFDLSALETSTQSMLDDETSPADSLISSTSTSDSNNELQVERDPPSISSAYQTCNTKTRSPEPIVEQDNIDGEALQPTKEVVIEIKRASDAGSGDGSKNPTPESPGTPTHASGSLSLSDGRDFFDDEIADQPALLFRKNTDGSPSNKTLETDTSKHLRRSRERITSSPLVQRNRKLCGLRNGGTERTPSLDTLSSLASDDLMMDNDLAQSITSLQSVDDYIERLDSSLRSGLNSLDERQLRQELSSSKTAVRQWSQLLEQNNLLDRQLAAMAQGINASDSLTASNNSLTNIGSKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Y4</accession>
    <name>A0A835G8Y4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000336">
        <property type="protein sequence ID" value="KAF9409127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Y4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032514950" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="637" mass="70186" checksum="D35ECB592505A916" modified="2021-09-29" version="1">MVGLLFHRAVLMSGSGLSPWSLVADPNKYAAIVAQHANCSPELTPPLLLRCLRERPLEALLSAPVQAPDFAYAFGPSVDGVVIDTGDLLVNPENGYEWGGQTVAHAPLGKQAQNAINIINAVLMRKSAVAQLTKYDLMLGVTKAEAYFAFSGDDVQYGIEADRRSKILKSFVRNTYSYHLSEILATIINEYTDWERPVQHPINIRDETLEALSDAQVVAPMVLTADTHSALRRNSYLYVFDYQTKYGDYPQRQGCIHGEELPYVFGAPLVGGLAHFARNYTKAEVALSESVMLYWGNFAKTGNPNEAQESDPIRAGRQERVRMKNIEWTAYEAVHKKYLNIDTKAKLKNHYRAHRLSFWLNLVPDLHRPGGEDVPSSHHQLEHEDTALQPTLKTFSPPFKKTTDIVITDTGLATKIPVLGILNITSPLNFNIIGVNTPTQSTAATEVHKTDATTATPPEDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRMNGQDGHTNGAHLKKRVENGQMPNNICGDLEGALTYQTSLKNDPATILSHHHHSHHQLPPPEFADLPSNNVAGMATLPRAPPPPKLGKSNINTLASGQLQENQPLLSAHQMQMINTSTLTKKNTQLNAKSNVTMEELRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9B5</accession>
    <name>A0A835G9B5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_009229</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000197">
        <property type="protein sequence ID" value="KAF9412206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9B5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9412206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="42920" checksum="0CAA432861134814" modified="2021-09-29" version="1">MDLSYSKEMNMKARNMREKNYQYVASHSSGTDLDSKYEKLAKIGQGTFGEVFKARARSQGKSFVALKRILTDKETEGFPITALREIKILQQLEHENVVKLLEVCGTRPSATNKYRAECFLVLEYCEHDLAGLLAHPNVRFSLGNIKMVMKQLLNALFYIQCKNVLHRDMKPSNVLITKTGTLKLADFGISRMFTPPQAGRVNRLTNGVTTLWYRPPELLLGERNYGPSVDMWGAGCIMAEMWIPTPIMQGSTEQEQLALISQLCGSITPDAWPGVRTLPLYSKLELPKHHKRTLQQRVQRHIKNQEALDLLDQILQLDPSRRCDAGTALNHNFFWTDPMPCDLASMLAMHRTSMFEYFHRKRGKEVGQMQQVAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9D7</accession>
    <name>A0A835G9D7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000315">
        <property type="protein sequence ID" value="KAF9409489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1785" mass="203516" checksum="CDDDB5BF3184C423" modified="2021-09-29" version="1">MQSLLVIQSPEFRESKIEFAARGSAAFCIAVATAPTLQSMLTKDDEIGKRILMRILHPDPALPPNKIQKLFKEVILENISDSTMEVILMPLTWQLQIHKPKENNTGLVRMKSQSSESLGSVLSTFSVINMTPIKDQHFTFSDVAKENKSSVSLIKSNTSGMILKILKSISTSSIDKSSQLNNVTLPNKPPLILSYNVSNVTLKVNPSTSFHQMVTMLSTPIQFKSAQRLVHVSPSLVKSSSELLKPEEQRLDQESNLHQETPQCQMIVETSLRFHKKDSLQEMVSLNEGLERKTDLQQQFEIPKSKSNIKTEQKVPVQHASMSVCYNPSKKIEEKYLVKSDIVYQEKIETQVECKSYLSACVTKKAKSPHMFYESSTRLETKCNLKDASIGRDEIVIYQNQAIQTINSVPPYLPNQTKVICEDKSTSDHGPIKIGILPEKRANTSHGASSDSGKPLCTSNILKLDKQRCGPKLFVPRTLTKVYTVNSVAYGESKMTPDISLKNTCCGTKKERIPFESQFKSKLNHVSKKIRLRTAQSPSNGADQSQGAMKSRETLITRKESINHAQLTGVLPLIRRCYCTMNVQVAGQNVTRKHHYHSPRLEPIPYPHQNCVKRRLVRKTTTMSGTNRTFNTSSSSTPTVSSDSRTRKYYLLRHKVKRCTACTRPVVGFKYQISPRSRQRHKQDVPISYTSGSINDFSEPKLKLAHTIRMPKDQTASKSSKSYYRYIRNSSRGDYEVGRCQKQSQSLMSQLCYRASNVTPMLRRCFYSLKLQKKGRLQKKREMQPMNQSKPRFTKVTADKRALKTIQNMKKYRYAELIPYEYATNTCIPGECDPVWLEKKKRLELRKSRRKQTKDFVVDSNMSHFSTPSIMKTSWKRREKHIHFHDLGGHLRPVRSRNILVRPNPPKIIIKNSGTKRSRQPRVNSRFNFNEEKIYDLNKKEPTNFRKYAYTHGKIKDSFSQDEKPKRDTDVQTVFHKQSQSSGFLKRCFCAFKCLTTSLKHRGKPDNVGHERTSLTLETNIINTQKRDLIPNLVTYDCEPRVRGHCKTHQLVIAHDKSAGPSKRGRKPESLTKEIFFEETNVTPQFFPRRQTVKISSNTSLNGDFFKDKFPNYPLVQIAPLKYARPKRNKSHALHKSPKGPFSLDINAENTEKKPNQLQTFSPDKATHATKPYNLHSHQVGPNDCKPGVCVPGRGDDLNRHKNERMGEEPMYGSGAHRKSVLVRSSLSLNIDLVSLQSPSVCVNNKITKRVIKSTETSSTRTSSISSSGKKLCLRDCQSQSDCIKTNCKASRASLLQRCLCTLKLQKRGKHAPFTKSIGTDATKPMIVPGTREIGTKTNQKYQYVLEPYKCRPDICVPGYCNPYDCKKRKNLENMRHSGIGTTRTTKSMSSVTSRDVDIKGMNSYKQKRNKRRTASMETIYRNEQPHQLSYVNVKKESKGSTVKPKLKRCLCTLTLQRLEFKNRLRSLGIYKEEAKVLTTDKTTSTKKKYSSHPSQPQPLDRRSKETDNYTPKECKPGACVPGECDPSECLERNKRQGVRRKSRKSGTRRRRTSQVSVASTTAQFFPKYLCKKTQHENFCIPQKIDRIVEEPRFPFFRNNLRHNLKRGVNISSNFNINIEFYKEKLPFTINEEKYSPFQSGDATSVGQFEKKSGLKLRIKEVCPNCLVLLEQTVAVRKKVRFAAVCSNITDSAIIRKQKDNLCVNNMGPKIVPCAIHWILSPWAAAMPLGDNLSKLKNQQYWRNAVTHIWSATSSIFYDAPHMADHSILRGVGPLEQRYSIYVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9L5</accession>
    <name>A0A835G9L5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9L5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="113" mass="13088" checksum="33E5EB84C55C9F42" modified="2021-09-29" version="1">MLLILYHAVDTFLHSLVYVQTVIEISKADLTEYGDKFYIAVLEADAACSRWRMHIRSTSQAKRLCKNVQRLNRAAFHKMRACHIFTVDATMAQAFNSLEVEYIIILLQFGYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA89</accession>
    <name>A0A835GA89_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_003182</name>
        <name evidence="8" type="ORF">HW555_008916</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000183">
        <property type="protein sequence ID" value="KAF9412604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000543">
        <property type="protein sequence ID" value="KAH9635568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA89"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015047">
        <property type="entry name" value="SYNJ1/2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08952">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01165">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="120"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="973"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9635568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121203" checksum="9AD3865DD89B89DE" modified="2021-09-29" version="1">MAMSKGFKVLEKSAPPNPYSIILQHRNKDSALLFESQAVVSLSSQETETLRKQYHKIADAYGVLGVLQLNSGENCLLYLVLVTGCCSIGKIGDVEVFKITQTQFLPLFYQTQGEDKVSEVRKLVNSGTFYFSWNSGKTPNLFDLTLCAQRKSKGASPDNRFFWNRTLFIHLIRYGIDCEEWLTRAMCGSVEIRTIYVGHRQARAVLVSRLSCERAGTRFNVRGCNDDGNVANFVETEQAIYIDDSVASYIQTRGSVPLFWEQPGIQVGSHKVKMSRGYDASTSACDRHFSQLKRNYGSLIVVNLLGSSLIGGSEGEATLSNAFQKHLNDSAHNDVVQIIFDYHQEVRASSIETALAKFRKIIEKHYDDISIFSAKSSDIYNIQKGVIRTNCLDCLDRTNSIQTFIGLEMLAIQLMLLQCIDKKQNVNRFEEVFKQMWVNNGNEISKIYAGTGAIQGGSKLIDGARSAARTIQNNLLDNSKQEAIDILLLGSTLNSELADRSRILLPSNLLHTSTPVLREMCRRANEFTQPTPIRITIGTYNVNGGKHFRSLAYKDVSLADWLLDCPNSALVNTVNLKEHPSDIFAIGFEEIVDLNASNIMAASSDNAKAWSEELEKVLCRDAPYTLLSSHQLVGVCLFIFVRKDLIPHIRDVALDSVKTGLGGTTGNKGSVGIRMVLYGTSLCFVCAHFAAGQSQVTERNADYTEITRKTAFPMGRSLYSHDYVFWCGDFNYRVDLDKDEIRLLVSQNNLQRILDHDQLLQQKDQGLVFKNCFEGEITFPPTYKYDLFSDDYDTSEKCRAPAWTDRVLWRSRKYTIDPEGTSDLAAGKLLHYGRAELKQSDHRPVIAILEIEVLQVSYTKCMEVFYEVVKDLGPPDASIIVQPFEGYNSEESAFDDNVVAAVLQELSTIGEVTLVRFIDDTALSITFREGQNALAAAQKGQIYACSIPLQITLKTPNWIDIVRAEINLCSNNTVPLSGEAQPERPLRSAPPTPRRQQPSRPPAPSPTPLVPSRAPAISPARPPPPRPAPLTPDAGKATTQPPIASPPADSVPPPTCAPPPLPPPESSTPPPAGPPPPVPARQGAPPPLPARPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB74</accession>
    <name>A0A835GB74_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF250">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40606" checksum="ECA009932EA397B7" modified="2021-09-29" version="1" fragment="single">MDELEHSSTQRIARIRVFKFRVDYFTDLDETDFFARFRLSKYAVNQVHNFIKHKIMPKSQRNQAVPTKTSLLLTLRYLATGSYLRSAADFCGVSPPTASRIVKKVTEAIAQLRTVIIKFPDNLSTLQDGFYEIASFPRVIGALDCTHVAIKSPEENSCFILRNSTWPCPVSDWPLQILTSVRTVSALVVGGNGSNSFVTSSTTSVKKLDELEHSSTQRIARIRVFKFRVDYFTDLDETDFFARFRLSKYAVNQVHNFIKHKIMPKSQRNQAVPTKTSLLLTLRYLATGSYLRSAADFCGVSPPTASRIVKKVTEAIAQLRTVIIKFPDNLSTLQDGFYEIASFPRVIGALDCTHVAIKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBP0</accession>
    <name>A0A835GBP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensory neuron membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_009131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000192">
        <property type="protein sequence ID" value="KAF9412342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF109">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9412342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="53386" checksum="FA24D76DF222C616" modified="2021-09-29" version="1">MMFDKWLKLPMPLDFKVYVFNVTNVEDVNRGEKPILNEIGPYVYKQYRERTILGYGPNDTIKYMLRKRFEFDPVASGDLTEDDEVTVINFSYLAALLTVHDMMPSFVGMVNKALEQFFPSLEDAFLRVKVRDLFFDGIYLSCDGDNAALGLVCGKIKSDTPPTMRPAEGANGFYFSMFSHVNEPLESGPYEMVRGRENVYELGNIVSYKGQKVMPMWGDKYCGQINGSDSSIFPPIKEGNVPKKLYTFEPDICRSVYVDLVGKKEIFNISAYYYEISESAFAAKSANPNNRCFCKKNWSANHDGCLLMGLLNLMPCQGAPAIASLPHFFLGSEELLEYFGSGIKPDKEKHNTYVYIDPTSGVVLSGLKRLQFNIELRQIDTVTQLKRVPTGLFPMLWLEEGATIPASIQQELRDSHKLLGYVEIARWFLLTVAIIAVVTSAVAVARANALLSWPRNSNSVSFILGPSVTHVNKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCB5</accession>
    <name>A0A835GCB5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCB5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="62" mass="7125" checksum="5391F84328EE5672" modified="2021-09-29" version="1">MVITFHYYALCKSIVAANNNNALTPLKFRVARPKREVYEQASNFRSHRTVQADSQRSVKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCR0</accession>
    <name>A0A835GCR0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="JACKWZ010000218">
        <property type="protein sequence ID" value="KAF9411652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCR0"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="234" mass="26166" checksum="DDECD680BC35A557" modified="2021-09-29" version="1">MTTIVVNDEQELVTKLASKIEKIANDAIENRGKFYVGFSGGSVLNYLCECLQTVDTDWSNWVVAFCDERVVPENDDDSTFGTYKRELIPKTKLVEQQFIKIKQGVSAEEAAKDYTEKLTKAFGSEDFVFDLLLLGMGPDGHTCSLFPGHPLLDETKLKVAPITDSPKFPPERITLTFPTINKARNCLFAICGSSKADMIKRILKDNDDSVPARRVKPHSGSLYWVLDQHSAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCR2</accession>
    <name>A0A835GCR2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000198">
        <property type="protein sequence ID" value="KAF9412169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCR2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="320"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="853" mass="97199" checksum="A304645DA3BD00B9" modified="2021-09-29" version="1">MLIMSWQLTSKAKNSEVIIRATPTVSCGEVLLYNVVDKEFQSALRPLALMQRLFICAKFSIRDNFIASNTATYNYIGLSCALIFRSFMLYYLISTINQMIGITSLLSLCDIDDFIFFSIGFIINYYSNIVQCNNNVFLILKLQNVIRSLQIDVKVMKLVISWTEEFQSNGVCNNECYWNAMYDQYVTILEAYKLLKITSRLQIWKSVSDTVVYYTIHTVCHGLMTEVILLQMRHIIPETQVKFTMFAMLSQMWLVKNVALQIVLCVKSERFYAAMEQVPSVCVELMQTRGCTDIVGLIMWAVLSIALFSVVLGDTLAMVQVRVSDGLLEGEMVQNEYGGSYYSFKGIPYAQPPLGDLRFKAPQSPKPWDNIRSAKEFGPRCFQYDLFVNKGEVSGSEDCLYLNVYTPEVTPEKPLPVMVWIHGGGLVSGSGDDFEYGPKFLVRQDVILVTFNYRLEVLGFLCLDTEDAPGNAGMKDQVAALRWVHNNIANFGGDPDNVTIFGESAGGVSVTYHLMSPMSKGLFRRAIAQSGVSVSYWAQSYKPRERGFALARKLGFNSDDVKEVYEFLKQQPIENLIKAKVPITYSEKQRTNVEVYFSVVDEKHERFFYGDMVDAVSNGIHEGVDIMTGYTADEGIMGVAVFGDYKESLEQAKNFPQFFVSYPMSLTLSTNDQLELGNRIKEYYFKEPIRVPDHWENLKDFYSMDIFVFPTMRWIKLSARSKKNKIYLYKFTCVTELNIVSELMGVGHLVGNKPVVAHSDDLMYLFSAIQQPILDMNSEEFKQIEVVTKLWTNFAKYGNPTPDDSFGVVWAPYSLENQDYLDIGNELKTGQAPDDEEIKFWENVLTEFGEKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD29</accession>
    <name>A0A835GD29_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 161B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD29"/>
    <dbReference type="OrthoDB" id="784140at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019395">
        <property type="entry name" value="Transmembrane_161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624:SF6">
        <property type="entry name" value="EMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624">
        <property type="entry name" value="RE42071P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10268">
        <property type="entry name" value="Tmemb_161AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55236" checksum="1F40C53784F93B75" modified="2021-09-29" version="1">MALLGAQLVITLIMVSVIQKLGSYSFARWLLCSQRLYRYLYPTNSELKSLAGVPKESSKGKKGGKHESNGKAETFHVPRSLDIQLETAPVTPLDVVHLRFYTEYVWIVDFSLYTAIVYLMSEVYTSVFPLKDEFNLSMVWCLLVVLFSFKILLSLTKQYFTSDESIGERSTCIVAFCVFLLVAMMVLIVSEANLEVGVDPAYDSFYENASKFLENQGLSSVGPASKLILKFFFAVWAAIIGTLFTFPGLRVARMHWDSLRYYGDNKMKSLLLNFNFAMPFVLVLLWVRPITRHYLTVRVFSGMEKPLMTSDAFDTMRIILVASTVVIRLALMPRQLQAYLDMAQRRLDVQKKEAGRITNIDLQKKIASVFYYLCVVALQYICPIIMCLYMALMYKTLGGYTWTGLFYESQEVCTMDDKTATVTDSIVEGDGIEQFQLAWENLKMVFTVDVYRGVFGFATWWCCFAWFLTTSLGLAYQTYFRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDU2</accession>
    <name>A0A835GDU2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="14">FTase-beta</shortName>
            <ecNumber evidence="2 14">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_014137</name>
        <name evidence="16" type="ORF">HW555_006921</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of FNTA and FNTB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 14"/>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDU2"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000007">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 14" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="15">
        <location>
            <begin position="58"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9415499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9639273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="45350" checksum="7A4AA9D51037A7FE" modified="2021-09-29" version="1">MENRIRCYEEISSETFDTENVVTDSSSDQVDVESVILKIYKQFEKSAEIEPEFPVVRKRIHCQLLKDYLRTLPQKYECLDASRTWIVYWVLHSLWLLNDMPDAETLSDVVKFLTLCQHDEGGYGGGPGQYPHLGTTYAAVNALSIIGTEEAYNSLDRSSLQKFLWTVRDVDGSFALHKGGEQDIRGAYCAVSIAKITNTYTDALFDKTAEWIVGCQTYEGGFAGCPGMEAHGGYAFCGIASLALLNKTHLCDIDALLRWCVNRQMRLEGGFQGRTNKLVDGCYSFWQGAAFPIISAILSQENKELLETVLFNQGALQEYIIICCQALPRGGFIDKPGKHPDIYHTCYALSGLSVAQHGTGAGDPFIVGRPSNELNRIHPLYNVAPHLAYNAVHYFIRHPPPVKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFG3</accession>
    <name>A0A835GFG3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFG3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2400">
        <property type="entry name" value="Lepidopteran low molecular weight (30 kD) lipoprotein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004943">
        <property type="entry name" value="Lipoprotein_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042046">
        <property type="entry name" value="Lipoprotein_11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03260">
        <property type="entry name" value="Lipoprotein_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="435" mass="48881" checksum="84266BD3594BBFA0" modified="2021-09-29" version="1">MHSLSGWKYAQGPNYITNSNKTYPYSECPYLGEYRLVKLPVSLNNLIEHVDYWGEGRIVTQHGISGFSDCYNVNHVFQLVSNGPDRGRKIPNRIPVVNYTNCDTSPYIKDHSVEVVTVMGAPINNSCAKDIARMINPDVGKVVAYGFENNSAEIRNLTSELKKKSIFYCPKYTLPSKLQGLTLFDSNMAYLNLTEIKDILYNNVTDGVYDDAVALTKIMDTEAGSEAIGEVVVKLIGEKCGNVMSYAYKLWNSGATEVVQNSFPTPFQLILKGEVVTIVNREYQQAMKLEVGDSKTDIPVLGDSSDKISKKVSWKFQTEVENGNVVFKICNLEHNMYLKLDENTDNLGDRKVLASLGNGEVKYTYYVEPVMTNGHVGFRLIDTQYHQAVKMDEKEDSNGTRQLWGHNGDPRGDNKSLDWVIAANTKIWEKEAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFI8</accession>
    <name>A0A835GFI8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008107</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000151">
        <property type="protein sequence ID" value="KAF9413772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032873584" description="unspecific monooxygenase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9413772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="398" mass="45842" checksum="CF6925F152C1C3CF" modified="2021-09-29" version="1">MKSLIAVGLLLAWYLIGKRNENYWKKRGVKFYSKNKVIGPYWDYFITQRALFETSTRNTDMNQAIGIGQILTPGLFVIDPKNVQQVLSGDFQSFNHRGMESIEGEQLSENILMLNGPKWKLMRQNMTPLFTANKLKNMYYIMDKSAQDFVKYLKNNPKTHEGNLFETLMMFCNAAKNGTMRDRTTGYEIEPTTGILSAQAFFFFSAGVEPCANAIFSTLILLSSHPEILEKVHKEIDEHFEKHQNNITYDVISEMKYTDKMLSEAMRIFPPIGHLTRQCVQNTVLPVGNIPVEKGTKMFTPIYAIHHDPELYPDPEVFDPERFSNERKPKDSIYMPFGMGNRTCIGERYAKLQVQAGLVHVLRNFTVKPQKHVKVTFAHDPLNVRPRNCDVQLIPRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGA1</accession>
    <name>A0A835GGA1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGA1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="64" mass="7479" checksum="071EBEE3AA4ABDF8" modified="2021-09-29" version="1">MTDLHEDEDTDADEDYENKCLICNDYGRDNELWYRGVLCGVWHSECSGYDYPEGFICDSCRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGC2</accession>
    <name>A0A835GGC2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_006070</name>
        <name evidence="12" type="ORF">HW555_005560</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000234">
        <property type="protein sequence ID" value="KAH9641454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGC2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000004">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9417344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9641454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="10018" checksum="7301CCABF1F2312A" modified="2021-09-29" version="1">MSEKKIIPVVKAEEAEEEEMVDPQTQLREVCSQKSDAQNLWSKYQECNDRVNSRSQTTETCEEELIDYLHVLDHCVTKDLFKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH80</accession>
    <name>A0A835GH80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIH1D1/2/3 CS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026697">
        <property type="entry name" value="DNAAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083:SF0">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083">
        <property type="entry name" value="TWISTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="3">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="184" mass="20609" checksum="7DE2FF3FD5C60032" modified="2021-09-29" version="1">MEFSVEHMEKLVDLLRPPEPEVLQGDDLPTTEFEINSTRGKIPPPEEKKAPKTIEEYEEQEAKEIENLGKAGVGLGDLKTPEYTMNYQQSVSAEDVYLQIGPKTPASASCENLIVRIKMPGDKKENVDLTVDTSSVAVVSSQYSLKLPLPHGIDPDRSKASWESDQETLVLTLKLDREFDFVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHH0</accession>
    <name>A0A835GHH0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHH0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="200"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="419"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="602" mass="65558" checksum="F0852EEC4B1412F2" modified="2021-09-29" version="1" fragment="single">GLFSRMTFREPVWVGGAGNTTGLQSKLGLSDGLLGCVDFLRINGDTYQLMKDAVATLDIDLLFTAECAPTLAPWKPPIEVTSESTQQREDHAIYDINDIVHFEDNDIVMRDAKRAKAHDQNKLDNSVVPFKTYSSYNDVKTLFGKDNKSAGAVADVDNDLKNEEKKEKSCECQHGGGCVANVCLCPLGYAGVKCEITLDLKVPRFNGSSYLRLPGLGSAAESWLDIQITLKPSSGDGLVLYNSERADGDGDFFSLHLRDYYVEFAFDLGAGIALVRSAYPVEANKWHSVSVSRAGRRATLRVRGGGAARSLIINDEELAVVSAALGGLNVDNCDDAANNCTNKNLCKEVVDPPVYPHNISETEPHHSIVAKKGFKQKIHKGKDLERNNEVATDLPYDGQTYMQVKYLSDNEVNWGDMNTYPSFTGTDSFIHIDDEDTMKRLVSYSLDINIRFRSVSSHGLLVWSGGARSPPDFLSLAIENSVLVFRYDLGSGEVVIIANHTKVDDGLWHRARATRNRQAGVLEVDGLGSVGKVSPGKLKQLNTENGLYIGGLPSISLSTGGRYARGLVGCVSQISLSGDFDIPLSLSKLPHTITNNVGRCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHL3</accession>
    <name>A0A835GHL3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="27404" checksum="B6FDA49AE98B7B0E" modified="2021-09-29" version="1">MNSSNVSKSSYLEPPTAEELTKMKVVSAPELPNPEDEEEASFRPQLSAPSYLHHLRENESPPFSKPELEPRPHILTGTIMNEEEAVAMIAAADADKENGLKKFIGNFLIEKNMVHNYALPEKNFLISLIMETIDYAAQRDFDAFKLAVLITIYLDSHLYFKWYYWQSPTTLWNYFKEVMIRHTIEDTPDGEEVFTAPECYDILTHFHSVYLANMPLIHIITFGTTRLKLIWPFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI45</accession>
    <name>A0A835GI45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_006249</name>
        <name evidence="14" type="ORF">HW555_006873</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000499">
        <property type="protein sequence ID" value="KAH9636434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI45"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9415451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9636434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="318" mass="36007" checksum="16F6896962C220DA" modified="2021-09-29" version="1">MGLCKCPKRRVTNQFCFEHRVNVCEYCMVTSHPKCIIQSYLQWLQDSDYNPICEICTKSLSEGECIRLTCYHVFHWTCAEAKYRALPRTTAPAGYQCPSCATPVFPPSNLVSPVADELREKLAGVNWARAGLGLPLLSEDQDMKGAVGRRSQSPIDHHSPFYTSTVDNPRGTPVGASDDESTGRSANGTPHSIVQISDEPVNIYDSSSLKRTDSLQGGQAPRKSVKTNEPLKLNTNYDHDENKYKQKSTFAWISRWWKNSLPSSRVRRAGGIYRRYWIMLFVLIAIIVVLVLLSRRDVDDENPFAFIQDDNQRVLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIE2</accession>
    <name>A0A835GIE2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000001">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF48">
        <property type="entry name" value="RUNT RELATED B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="41"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="416" mass="45084" checksum="B8ECDC60A6A33AF5" modified="2021-09-29" version="1">MHLSSEVSSTTNGLGHEAPSSSYGSSLPSQPLTAELLAERTLEGLLADHPGELVKTGCPHVVCTVLPPHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCSAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIMLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFPPDPLMGSLPFKLSGIAHQLAGLPGSEWGALARHYPPPLLPTPAHFTPHVLPPHAQPQHVPPPPRETDVTSDNPITMHAHSTTSPANSRPSSPQDDDISVTASSSPPPDDRPGAFTSVTRSRKPMQPLPAPSSLFHSALAAQLFLNSPLLPTPPAWLYSQLYGGYDWWLRPPPPQEDSNNSSPEREDEGSTASGTGKKRPASPEWSEQGMRTRSKSLITSERRPVDVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIT5</accession>
    <name>A0A835GIT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor Adf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="145"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="40604" checksum="0C868A194C70D027" modified="2021-09-29" version="1">MKSKVKGARTKNMDKLIAAVQARECLWDKSYRGHRNRFKLERYWNEVAAEVGTTSLNCRKKWKNLKDQCRKEMKKNPTESEWPHFQKLKFIHHQFVAEDEEGDEDTTDEVFNSLDESIKRPKLGYTMRKKLLMNKRRAIDVDMNKLIDLVRVREIIWNRSLKGHHNWYKLDESWKEVAQELDCTRDEARLKWKYLRDQARKEVRKQSGSDWEYLPKLQFLTNQFNDYEGNELPDESYTQDYDADQGSSYYNIEPTNDVSVKEDDFDEFDTKPIIMETDFYDDDDDAQKSATTEPSEPVAKDEDIGFFNSLLPHVKKLGPAKKLMLRMKIQEMVYNTVYNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJG2</accession>
    <name>A0A835GJG2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_005287</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001370">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="735"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="780"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="966"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="107"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="393"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="740"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1062"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9417706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1305" mass="143556" checksum="7DAEB7CB09EFBAD6" modified="2021-09-29" version="1">MGTKKKKEQKKEPEQTLSYYQIFRYATCTELMATIMGIIFGLASGGGVCYNLVQIGELSTAFVERTTYTERLTSYLPLTVAFGGGRRLLNASYEENMLALIEDAKAMAIGLFLSIGVSLIFCMLSVGLISWSALRQITRIRMKFLNAVLRQDMSWFDTDSEFNLASKMSENLMSLKEGMGDKLAVVSNLVGTAIICLCTAFPLGWELTLACVSIMPFSIAVSIILTNYQTKSSILEMESYSQAGKQAEEVLKSVRTIVAFNGENKEVDRYTKLLQPAEKQGRKRGLYTGLGNGFNWVLTYSLNAIGFTYGTRLVFMDWDSPEGERKYLVGVVYSILFSVYMATQSVTFCVPHAEVFAAARGAASSIFQLIDRVPLIDSLQKGGLTPRRVIGEISLEDVHFSYPSRPEVKVLNGFSIKIKAGECVALVGSSGCGKSTILQLLQRLYDPLSGSVKLDGKDVKNLNLGWLRSCLGVVGQEPVLFRGTIFDNIAIGFPEATREEVQTVAEMAYAHDFITNLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTIMVSHRLSTITNANRIICMDQGAIVEEGTHEELMKTKGFYYKLVTTGNETKEPEEIETVAEEGDGEENVEPVLAPRADVKRKSNRRVHRHHSIKKDSHDWMTPRGSICSVVSTGLQNFVYNADYESDEEKDEEEEIKPVSDWQILKLNAPEWPLITIGSIAAFVQGACFPVFALLFGFSSGIFILDDRKEIIYLADLYSGMFVVVAAVAGVSMCLQSTTFTTAGLKMTTRLRQQYFSSLLKQEIGFFDKESNTVGAMCARLSGDTAEVQGATGLRIGLILQGISSVLVGFLMAICYNWKLTLVGTVFLPLMVGSIWLEGIVSQQSQINERTAMEAATAIATEAVVSIKTVQSLGVELVFLKKFEEALNEACLAVSKKTRWRGLVLGLGVYVPFMAYCSATVYGAVLVAYGEIEYKIVMLVNEAIMYGAYMLGQSLVYVPSFNSAKTCGARILALIKRTPRVKTEDGIRDKKDWAATGNFSIRDVEFSYPTRPHLRILKGIDLKVDAGKTVALVGSSGCGKSTILQLMQRFYDPDSGNIELDSRDIRSSLTLPRLRRQLGVVQQEPILFDRTLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKGYDTNLGSGGAQLSGGQKQRVCIARALIRSPRLLLLDEATSALDANSERAVSEALEKAAKGRTCITIAHRLSTIKDADLICVLDKGKIVERGTHSELFNQRGYYWRMCKGQNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJI3</accession>
    <name>A0A835GJI3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Androgen-dependent TFPI-regulating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_004227</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9419142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29510" checksum="146B21F98AA31FEB" modified="2021-09-29" version="1">MRLVNMRMGGYIATIFMHVSNIVFMAWYSKRNAGNSKEVLQFKSLEYRFFTTWTFILQLAYAVYALACEYFILKNAKKKDYKLPSPITEFREILFAGLVWPCSIVVFTVFWGLYNYDRSLIFPKFLDEVIPPISNHVIHTMIVPVVLWEVMFRPRQEPETHARNVMQLTLHLCVYVSVMYFTYIERGVWLYPIFRKLFGTVYFFIALAAIGLMFYAFYYIQWPLTKMLHAPPKRMTLDQSRLESIPAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJX6</accession>
    <name>A0A835GJX6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine-protein phosphatase non-receptor type 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000079">
        <property type="protein sequence ID" value="KAF9417039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJX6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000026">
        <property type="entry name" value="tyrosine-protein phosphatase non-receptor type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="399"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57454" checksum="10BF82C8AD714563" modified="2021-09-29" version="1">MLKGGYPAKLKKVLIVTAPLWFKAPFRILRLFVREKLRERVHTVNAPQLGLHVPRSSLPKQLGGLHEPDHAAWLEHCKNCYTNNLQNAKLDGVIDEYVISNHIPPINAQNGIIEHEGDMTSDRATRLGDSNTDMHISGDPPYTCDPSPLRHTHGYNGDMKSRHINSGDEDDMDISTRGTWSSGEVSPGLSDEEGGGGGAGETPQALLQRVRALGRRGLAAEYDEIRSRPPVGTFHHAKLPSNLAKNRYTDVLCYDHSRVILSQTDPDDPTTDYINANYVDGYKQKNAYICTQGPLPKTFSDFWRMVWEQGTLVIVMTTRAVERGRVKCGQYWPLADGQHVVYGDFAVTTQAVEHDEDYTVTHLLLSDLKRGGSRRIWHGQYTRWPDYGVPGGGSAQPVLRFLARCRRAQALALHDLDLAWAGHKQGPPIVVHCSAGIGRTGTFLTLDICAQRVSAEGALDVRGTVERIRAQRAHSIQMPDQYVFCHLALLEYAVMQGYLDSADLTGFDEDNEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJX7</accession>
    <name>A0A835GJX7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="163" mass="18825" checksum="730DD587C9A37F73" modified="2021-09-29" version="1">MFQARMELPVLDKFCFVFDLKTGCMVMGLANTIITFVLTLLLITFAVNIKDISEAQMKRDDVEYAMSSVVYTIVVLLIVLLVVKFLLDLVFVYAVYKEKCSLLKKYCIFWIIFLVLYIIGFLKTLFHMDAGHVISQIIFIAENFYFIVVIRSYLISINEDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK83</accession>
    <name>A0A835GK83_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK83"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000028">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF5">
        <property type="entry name" value="CELL JUNCTION PROTEIN VAB-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24576" checksum="29D3951DE900A54C" modified="2021-09-29" version="1">MQKSRSTRIGIIKSTDLPFMAFIGHSANSREPCSEGKNCCCVSFQVIALICGLLVVILMVLGLASADWLMAAGWRQGLFMHCIDPEAPTPLPFDITAQPGCYAARPAPYIKAAAGLCVATLAADVCGALLTGLGLRSADHRTKFRYYRFAVLAMSLALMCILIALVIYPVCFAAELNLGNRSVWEFGWAYGVGWGAAIFLFGAVVLLLCDKESEELYYKERKVSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKV6</accession>
    <name>A0A835GKV6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKV6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="15301" checksum="1091568875753584" modified="2021-09-29" version="1">MRADDDSKDTQPEFNMHRIIMGCIDKFNVTEEQMKKAITTKDARAVTPCFWSCCYKKTGVLNSEGEYDLDSTLNLAKKMFVYDIYMKIEDIAKTCGSVNDDSVIDGDAGCERGVLLANCMIENGNKAFPELFYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKX4</accession>
    <name>A0A835GKX4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKX4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000068">
        <property type="entry name" value="Islet cell autoantigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024114">
        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006723">
        <property type="entry name" value="Islet_autoAg_Ica1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164:SF4">
        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
        <property type="entry name" value="ISLET CELL AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04629">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01237">
        <property type="entry name" value="ICA69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="111"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="508" mass="56049" checksum="A09202BC025ABF8F" modified="2021-09-29" version="1">MFFTLAYANLALKAGRDIEPKSSKIDMSGIDTRRESNGHLDPVTAKCYPRSYGFVNNDASNTTKESVAVFFTCRSLVDGKVASNMMQHQYWVTKKTVLKKLGTKEDECIVASDAELDAKLELFRSISDSCLQLQRVLDQYQERLCILAQEENALGKFLRDAGKNADASGKHMVSAGKAISYSGQQRLSVRGPLLRLYHEVETFRGRAVSDMRATVSAMEKARIEYRAALSWMKSTSAQLDPDTGRGLDNFRKAQRQVRESKKLFDKLTLDVLQKIDLLAAARCNMFSHVLSNYQGSFITFATKVAQTLTATADTMNATPQYEFSILKELSQTLGESESKQEVTPQDKDQMLFFQDEFKDENPETSEKSKTDNENGKQPSNEGDVKPSTSVNLIDTSYLESESSSGNAGILSELAGLQLDCGDTRGDFGNFLPSQLLQNSPSLLQGPMTPLSSNNNQAVKSVQTSKPAPSSVIPKKDDKAAWFKLFAELDPLANPDNLPGSNTNQSHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL00</accession>
    <name>A0A835GL00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mab-21-like HhH/H2TH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL00"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF69">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="2">
        <location>
            <begin position="643"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="981" mass="113694" checksum="9D65DF220AB3694B" modified="2021-09-29" version="1">MGNCKSKKEKPKEPATFFEYEKKREAVLDEQKKLMLKNSHRRFGEQKQPLPPQAQAAPPSVASPVHAPAPHVRSYDEEALDRMREDLRHRSDRFLLNNILLSIQFFENYEREMHQIKNNPISEREHMINEAMVRQNKHVFFADRLQECVHEHVIYKGKDKQQPLLAPRLFVIHDNVEASEPGDTSDYSAVLDAPFYKLQIEDGVDPGYIKLKKIEVLESTLHKENEVINISKAESDDSIYTDSAKESNASDEFPYSSRKDDESFQKVRPGMDIKMMPSSIEPKMSHIQNNGGGGRRYSGPIKQYSLQVAKSDISNMRHRNIEDCVPEEDDTYESNTNFEMDNNFPMLSKTTSLMSERRLSGPTMYRKKRPKSEMRSAVSEGNLTDNTETSGYRSNSSSRQVEFSENESDYGYATITEAATPRKIELSLRSNYSLTSGALPEEAWTTVDVKVLGEETEEDDNDDDEKALDPANLFESVYYLNSLRFMKIFVDNFIMNLGSGLGLTSSEIHSALTQGACIYCDTTRNGTRFGYEIFPALFAAWPNAANPWIIRERKVIRNPRNNNLYQWPNQNMVSKAIGFGCLLVPIGFRIKRGLNPNQPLQWKLIFPAVERYLESYLAHAQIRCYLFALALHKTFIENETAKIGLDASHIKNHLFWRCEDNYARWPEDQLGTVLLEFLESLYGNLSKSRMPNYFIDNCNEIKNIPHPLLREQQSRLAKIIEAPVLHMLSALNKIKYTKRDFYPKFQSRRLFQILTCKDPLRLINPNIPKVVTPSKYEDSSESETESGFWETTKAYDRDYRWRKAAHRKTEEKKKSKTTTKQQKEAWKQYTIPLKMDQIRRRLVLEFFIPHFIAMARSSEKFEAIRQALIYLEQAQRLSILLSEETGGDSTAKEYLKIIKEKLIDCQRKLVQQSFLPQRSDINRKRKPQPRHKQRPKFEDIQDSPVESPGIPAFTFVDVHTENSIRDHLKLNEFVNGEESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLY1</accession>
    <name>A0A835GLY1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLY1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="442" mass="49615" checksum="72073690668A1E04" modified="2021-09-29" version="1">MWKHATFKLNDPFATRRNFGKRSLRSFMKKGKKGQQQNSSEKSSSNNQLNGEPSPIIYRRALQYSTASTTGARSTVGSPDRYIYGGSITPLPRSRFQERLRSTSHHEVQSLSTTPRLARSEVSGSRLSVESTNPFDEDGPVPPVRASRRKKKRAPLPPGPIYTTPESGDTTVTSVTSESEISKTEDKKLNNTDGDLELENMNLNIELKIVEDEDVKDKTESIDDKPKSPDAVNNNTEVPVTVTEKVVNEETTPTESKENDVTLRSSSEEDILSSAAFPKIDIVTYRRNSSVNEDDIRLRRGNLEDFQTLNNKRSKSLTNALDTTYTTYDINLNENIVHMNTNGNDAPQKVVCKLYEDPQTKKSIETISSTEKEFLEIDRATRELEREINKLNSALNEDDIPSVETRLSVSEIKRRFDKKDASSPNPIPKPRRSHYGGGSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM03</accession>
    <name>A0A835GM03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replication termination factor 2 domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_003485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="330" mass="37000" checksum="894AEE79DA6A8467" modified="2021-09-29" version="1">MGCDGGTIPRRDELVRMKKKPEQKDKDAERSFKWRNCALSQQPLQEPVVACGLGRLYSKSSVLETLLDKETKPDSISHIKNLKDIKDLKLVKNPAYTAADHTEGTVGEGNAPYICPISGLEMSGKFRFVFLWSCGCVLAERALKEVRQNLCHMCQQPFTDNDIVPLNGTDEDIEKLKEKMAVRVASRKSSKKSKAEKAPKTEVKIEPLTPGPSTSTEVSSDVKPETDVNVKSESEPEPSSSNAVKKEIETIPLSLPKYNPNKQARGHFGSSKRVHPTELAQDPSYKKTKKDYSVAKDPQTSEVYKSLFTSHQTDKNQQRAHWVTYNPFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM04</accession>
    <name>A0A835GM04_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM04"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="605" mass="70580" checksum="8C0A49255F9B17A4" modified="2021-09-29" version="1">MQTDNVSMIEFDSESLVMKVMCHKIFKSNKIDTPYSERLTSSNVTHSIVFVRVDTRASIVTARVVSVRRDRCETDINEKNVEHPDYTEEEWRLLNNIYDDVFPTSQLEEDKSNESLANDSHNVILGSEEDLPIDTTPNVTDDPANIPSLSSLISISDSEFSNSPNPSSSRKRKPTYKTDLGRKRKRHIKDWVDVRRKTLTNCGLQYVSKKGKIVPAKSMKPPCPLTCKLKCTKDFTDSMRKHIFDQFWQLSDHTKQWEFINKFTKRFDKKRMTTENPSRRKFTTKYYLPLPTDDSTFKTQQVCLKMFCGTLAITDQIIRTAHSKLDSCGITSSDNRGKHLNHPKKIDDEMIRSVCDHVKSFQPVESHYTRKNTSKLYLDNSLSFNKMFSMYKDWPELSKYNKTAETERQYRTIVNDHMNIAFFIPKKDLCDKCHAFSNEVSPTEEQVLAHNKHILNKETARKYKAKDKEEAIQMSQDMLYDLKELLQNRNFKKNTSNHDVKWNNIKEVCVKRSEPDIILYKYDLEGDYFRLNTLVQTRRNKKTVVDYCNDALKPLYSDTLPIPEAKHKDLIQLCEAGHIPRQYHAFFKNLKKVQSENVSGSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMY0</accession>
    <name>A0A835GMY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translocon-associated protein subunit beta</fullName>
            <shortName evidence="11">TRAP-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_003391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAP-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMY0"/>
    <dbReference type="OrthoDB" id="5860827at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008856">
        <property type="entry name" value="TRAP_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016400">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033016346" description="Translocon-associated protein subunit beta" evidence="13">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9420330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="20939" checksum="392F167339C37FF1" modified="2021-09-29" version="1">MSAKLLSLILIIATAVTAEDEPAIARLLVSKQVLNKYLVENMDILVKYTLFNVGTAPAVDVKLVDNGFHPEVFQVVGGQLTAHIDRIPPQTNVSHVVTVRSSRYGYFNFTSAEVTYKATEDATEVQQSISSSPGEGAIVAFKDYDRKFSSHILDWAAFAVMTLPSLAIPFGLWYSSKSKYEKLSKPKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN86</accession>
    <name>A0A835GN86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032666145" description="Juvenile hormone binding protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27348" checksum="07A868731D696B8D" modified="2021-09-29" version="1">MAVYRSFLVLAFAGCVLSEFGAPFEPCDKDDIKCLSAATESFLEKTCHGLPDYDIKAIDPLIIPELKYEVDPDMGLYFEFKNLNVTGLKNQQISDFRMDTDKKSVVLKTKATFNIVGDVKISLTKHNKVFNGVYSAAYTALGNSKYGYSLVQKGDLEYFEVGPETNSCEILGEPDIKLDSNLQNVIDQDADARALKPSFETKKVTLRKNTLCRVVETAYITVIHNIRASAKIYPCRAFFNKMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNV3</accession>
    <name>A0A835GNV3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="167" mass="19328" checksum="0A756E8FA9E84BD7" modified="2021-09-29" version="1" fragment="single">RIALQDAYRQERAKLKYANPKYIKDPVVFTGRRNRNSPYQTNMSCTILVPFGNNVSFATTFTMVSGGDFRLVTKACDCSKSKWIHDFMQSYTNLTLRKCPYPPGRYAYYNIELPPKNIPLPIVQGDYWIKFEFFVTDTKEPIVEVDSLLHYDPTANAKRSKGRKGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP95</accession>
    <name>A0A835GP95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027351">
        <property type="entry name" value="(+)RNA_virus_helicase_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01443">
        <property type="entry name" value="Viral_helicase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51657">
        <property type="entry name" value="PSRV_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(+)RNA virus helicase C-terminal" evidence="3">
        <location>
            <begin position="634"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1523"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1828"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1523"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1862" mass="205328" checksum="CAE126E35521E460" modified="2021-09-29" version="1" fragment="single">AKSPGYVWASCYDFGQRRRKVWTLRRNIFAAPPHETHPPHLPPQGDLTPSRPNFATLEVGIPSLGSFERARRDLSIGPYGIVKFGSTTHKFQRRNRNSLGTTTYTHIGLTPSELCSSIGLLIGPALAEHQRSNTAKTSSSVSERTIRTAELPKVPKAASEPDVTGCETATQHSDATASVFETPTQELCRVSDIVLNWEQCGVSPPHQIVSDDDSSVASSAGGADRPERKSLLYRTPRRGTGVEMDLATREANHLLQKGKDALETAGNMKRECKAVTHECLQGLYETVLSLADSRARHKYNLEKERSRHAQELVRVERAHSREVMALKSELSIMRSDLLETKKEAKGIREWLGHETLDALNGIKELKDEVRAASQRNLTEHEKTRQHKPAEGKKYDPTGEGLSRLEQQMTSMSNQLDVLRMAQQKLSSELTRPKPDSSAPIREIDILPTARFEEEMEKVRGLLAEIKNKPAAVPPHPQNIDIAKYTQPLAERLEIVSADLRVLRDKEPPIPTPAAPSLDAELAVVEVKRALQKIEKDVADLSKAERPPQQEQGPKTFAQVASTPRTPVTPAKGPNHTLIVSSVNPQHTGDNVIERIRDALDLKATGARVDAVRKARNQKVVLRSNGFKANETYYRLTVDEALMNHFGAIVMAARLAGAREVVLVGDVNQLPFLDRENLFTMRYSRPVSVAGITQELLCTRRSPMDVALALSEIYSGIYSSKTALSTVHSLRAEGYTGAQIPAAAQNTLFLVHTQEEKALLIDQGYGAGEGSRTLTIHEAQGLTYDSVIIINTKSRKLAIHNSIPHAVVAVSRHTSSCVYYSDDADDATGRFVRKAMAATTKMVIDYNLKAAIQHRDETVMGELLQLASSLVGGGSGGSAKSPGYVWASCYDFGQRRRKVWTLRRNIFAATSEESACGRYVRTEDFTPKHQVNPEGTPKPFPITPPTLGSSDSGSQDLIRPPGCQNSPSPTSQPHPPPTKNLLLAQYLPPENPPPSPPHFTPHPPSDALPQKIFYLSNSLPTKPTPPTSPLRVTSPPRGLTSQPLKLAYPSLGSFERARRDLSIGPYGIVKFGSTTHKFQRRNRNSLGTTTYTHIGLTPSELCSSIGLLIGPALAEHQRSNTAKTSSSVSERTIRTAELPKVPKAASEPDVTGCETATQHSDATASVFETPTQELCRVSDIVLNWEQCGVSPPHQIVSDDDSSVASSAGGADRPERKSLLYRTPRRGTGVEMDLATREANHLLQKGKDALETAGNMKRECKAVTHECLQGLYETVLSLADSRARHKYNLEKERSRHAQELVRVERAHSREVMALKSELSIMRSDLLETKKEAKGIREWLGHETLDALNGIKELKDEVRAASQRNLTEHEKTRQHKPAEGKKYDPTGEGLSRLEQQMTSMSNQLDVLRMAQQKLSSELTRPKPDSSAPIREIDVLPTARFEEEMEKVRGLLAEIKNKPAAVPPHPQNIDIAKYTQPLAERLEIVSADLRVLRDKEPPIPTPAAPSLDAELAVVEVKRALQKIEKDVADLSKAERPPQQEQGPKTFAQVASTPRTPVTPAKGPNHTLIVSSVNPQHTGDNVIERIRDALDLKATGARVDAVRKARNQKVVLRSSLTITEYACLEDLTPENPETHQATRPQIYTDGSKIEGKVGAALTWWENGKELKSCTFGLEPHNTVFQSEMYALFRAVEMVRESGATSVDILSDSRSSLDLLRGPSVTHHLALKIKRYIKEIEEEGREVRFFWLRAHVGTAGNERADELAKRAALSGSSSDYNQVPISYIRKSIREETIKRWQERYQVSSTGAVTKAFFPDVLVAKRILANMILSPVLTQGGPGAETRNPAESAHTPYHHGETGHKGAILGIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPN3</accession>
    <name>A0A835GPN3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="126"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="576" mass="65180" checksum="0CEA04E07196EAE9" modified="2021-09-29" version="1">MADLLSIHDDIKLYTTSDKFYLEPTINPTEILVIDRVSGEASVKDIGSVKIPIPANAYRPVCGFLGSIKLISGLYLVVAKYRILVGKLNGHEIYQLAGTDIIPYARSNTHLTNKQIEDNATYERMLRAALDTVGIYFSYTYDLTHCLQRLHSVTPDFHKMSIANRADPRFLWNGFLLRDFSHQQFSRFTLPIIQGFVSINNVTVNGHALTWSLVSRRSVDRAGTRFFMRGVDAQGNVANFVETEQIIERGGEKSSFVQTRGSIPLFWSQYPDIKYKPAMQLSHEDHVAAYTKHLRDQQQRYGNQVLVNLIDQHGKEEALERGFRAAVAAAALPGVRYEPFDFHAECRSMRYYRLNVLIDRIKLEQAEFGYFLSRGGTILLRQNGVFRTNCVDCLDRTNVVQSLLARLQLTAALRLLAVTNTDDEKHPEFDNLFNNVWADHADVISTQYSGTGALKTDFTRTGKRTRLGLVRDGINSLTRYYKNNFSDGFRQDSIDLFLGKYVFPSVLLVAMSMFCASATLPQRYSSEVLLYLMFWGAAVTATLSFIFRHGKEFVDWPRLDAGGLAAARALPPPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQU1</accession>
    <name>A0A835GQU1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_003871</name>
        <name evidence="4" type="ORF">HW555_002606</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000215">
        <property type="protein sequence ID" value="KAH9641745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQU1"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000045">
        <property type="entry name" value="lipoyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="78"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9641745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="419" mass="47075" checksum="A74F50F26BC64D6A" modified="2021-09-29" version="1">MAQSMMKKIVASSACLVVGITRRTSSRSLVTASKNLNAKKERDLPAEGEITKSVFMSQSTDIFTNLALEDWMYRNMDFTNHHVMMVWRNEPCVVIGRHQNPWLEANIPLLNEREIALARRNSGGGTVYHDRGNLNITFFTPRERYDRKYNLELIKRALFRGFGIKSIINERQDMIVRDKYKVSGTAAKLGRLTGYHHCTLLVNANKADLSRALAKREHGIQTQATASTRSEVANLSEMDNRITVDSLQTAVGYEFLRTAALSLQDGGTSQISKQRGFQYINPTDDWFPGLADIKNELQSWDWNFGKTPVFTVSRTFPVPAELLAPSKVYSATQELVISMSVEKGLIEDVTLNIPPGLVESGFHGEASVITHLKGKRFTSEALNALQDAMLTRHVGNDVRKLDDKEQFVAKCFDQVVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQY3</accession>
    <name>A0A835GQY3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="72" mass="8528" checksum="1226D9E2E1109C95" modified="2021-09-29" version="1" fragment="single">LKLYYIYIIGNIERSKEQEVTGAGVARQSLSLFQDTAARAVTLSFKVLLYSYVFYEECEDFRRGDYYDEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR04</accession>
    <name>A0A835GR04_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="85"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="586"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="950"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1671"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1342"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2000" mass="226038" checksum="199BBFC05F37CF29" modified="2021-09-29" version="1">MYNKHSVTRFFKTGLQTGDSSLPRKSRCQVKSGLKKIAKPQRKGNLRREINNLKRNSLKKNKKKTTDAEPPSHPAFQDCRSINEFQYLNRIDEGAFGVVHRARDRQTGEEVALKQLKNINQREGLSIAARRELEILIKMKHPNIVAGGGIAVNSLGEEVFIVMEYVDYDLKSFLETMCVNGQMFSTEHVKCLMTQLLRAVQHLHDHQIIHRDMKTSNVLLSGNGVLKVADFGLARECESTPRQYTPGVVTRWYRAPELLLLSSEYSTPIDMWSVGCIFVELITLQPLFPGKSEVDQLDKVFKELGTPSDTIWPGFSALPLAKNIVFHNYPPGGLRKRINDGKLSCSGFSLLHGLLAYDPAKRMTAFNASEHGFFKEDPVAIEPAEFLTEYFTPVDMWSVGCIFAELITLQPLFPDTTEVDQLDRIFKELETPSETIWTGYNALPIVQHVIFDSGRLTEEDKRRKTFGLWFFFAARRMTAAGALELAYFKEELVAIEPDWFPMSMYSVDDDQYSGTETEDDISSHSSSTVSALDDNIIIAKHQRKGNLRREINNLNQNSLKKNKEKTTDAGPPSLPAFQDCRSVDEFQYLNRIDEGAFGVVHRAKDRLTGEEVALKQLKKINQREGLSIAARRELEILIKMKHPNIVTGGGIAVNSLGEEVFIVMEYVDYDLKSFLETMRVNGQMFTTEHVKCLMTQLLRAVQHLHDHLVMHRDIKTNNVLLSRNGVLKVADFGMARAYESPPRQYTPGVVTRWYRAPEILLLSREYSTPVDMWSVGCILAELFTLQPLFPGTTEVEQLDKIFKELGTPSEAIWSGFKSLPIVQHLIFNSYAPGGLRKKIGRDTLSDCGFCLLQGLLTYNPLSRTTAADALEHEYFKEEPVAIEPSISVPHKSRRQVKCGLKKIAKNNHKGKIRREEKNLKQKILKKKTEVKQETSVTKPPFHPCRSVDEFQYLNRIDEGAFGVVHRARDRQTGEEVALKQLKKINQKEGFSIAAQRELDILLKMKHPNIVAGEGIAVNPLGEEIFIIMEYVDYDLKRFLETMRVNGQMFSTEHVKCLMMQLLSAVQHLHDHQVLHRDLKTNNVLISGNGVLKVADFGMARECESPPRQYTPGVVTRWYRAPEILLMSREYSTPIDMWSVGCIFAELITLQPLFPGKSELDQLNKIFRELGTPSDTIWPGFSALPLVRKIVFHNYPTGGLRERINCGRLSNSGLALLQGLLAYDPAKRITIADASEHGFFKEEPVAIKPAEFLRRQINNLKQNSLRKNKEESTDAGPPSHPAFQDCRSVDEFKYLNRIDEGAFGVVHRARDRLTGEESRCQEKSGLKKIAKHQRKGNLRREINNLNQNSLKKNKEKTTDAGPPSHPAFQDCRSVDEFQYLNRIDEGAFGVVHRAKDRLTGEEVALKQLKKINQREGLSIVARRELEILIKMKHPNIVAGGGIAVNSLGEEVFIVMEYVDYDLKSFLETMRVNGQMFTTEHVKCLMTQLLRAVQHLHDHLVMHRDIKTNNVLLSRNGILKVADFGMARAYESPPRQYTPGVVTRWYRAPEILLLSREYSTPVDMWSVGCILAELFTLQPLFPGTTEVEQLDKIFKELGTPSEAIWPDFNSLPIVQHLIFNSYAPGGLRKKIGRDTLSDCGFSLLQGLLTYNPLSRTTAGDALEHEYFKEEPVAIEPSIIDEGAFGVVHRARDRQTGEEVALKQLKPINQREGLSIAARRELGILLKMKHPNIVAGGGIAFNPLGEEVFIVMEYVDYDLKSFLETMRVNGQMFSTEHVKCLLTQLLSAVQHLHDHQVLHRDLKTNNVLLSRDGVVKVADFGLAREYESPAGQYTPGVVTRWYRAPELLLLSSEYSAAIDMWSVGCIFAELVTLQPLFPGKSEMDQLNKIFRELGTPSDTIWPGFSSLPLVKNIVFHNYPTGGLREKINDGKLSNSGLALLEGFLAYDPAKRMTAADAIEHGFFKEEPVAIEPADFLTWPALCADPDEALGTGSHHCQLLLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR16</accession>
    <name>A0A835GR16_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR16"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="12554" checksum="980B0A040BCB3ED1" modified="2021-09-29" version="1" fragment="single">EGTYVGCDANGNKYFTNCNYMIGRSRWVEFNNNYKWDYDATQITSEWFGWLHYKTDKLPCEDCAKRALHGCCSAHAWLQPFTENLTSTEEAYYPYSTTRPHIRVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR70</accession>
    <name>A0A835GR70_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_004118</name>
        <name evidence="14" type="ORF">HW555_000757</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR70"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008545">
        <property type="term" value="F:JUN kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06616">
        <property type="entry name" value="PKc_MKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000090">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000126">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF15">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="108"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9633404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="46378" checksum="FD7EC67FB96B30DD" modified="2021-09-29" version="1">MSKNGEVSSNQGPSRPTMPKPELNLFGLEKRKGLNLQIAGGPSGDGAAFMPFPANPPPVQRPRVPSRTIRDVLPENTRDRCRIYPSMQSSGKLQLSATEVYDFTSDDLQDLGEIGRGAFGAVNKMVHRKTNRVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECGYIVQFYGALFKEGDCWICMELMDTSLDKFYKFICERMQTRIPENILAKITLATVKALNYLKEKLKIIHRDVKPSNILLDRRGNIKLCDFGISGKLVDSIARTRDAGCRPYMAPERIDPGRARGYDVRSDVWSLGITLMEVATGAFPYPRWGSVFEQLQQVVQGDPPRLTNTNNAFSNNFVNFVNTCLIKEENQRPKYNRLLEHPFIKGIDQSRADVAAYVCEILEAMERNGVSPFTTDQPAQAWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS80</accession>
    <name>A0A835GS80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23826">
        <property type="entry name" value="UEV_Morgue-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="363"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="515" mass="57049" checksum="13060AFD50077488" modified="2021-09-29" version="1">MFAMTPEFFQFMKKLEENGDKLTSTPPSEPPLDFEFDNSTCHVCNGYYGPSFGEPVCVTCHAFLFPDFPSYLPSSYFYSEKTDDGDSGNDEPSDLNYSSERKVNRACTVPSWWYYRSSLDSETSPEDEASRASNSGAGASSSGNCSGVGGNGGAGRGDGRMWPEGPSRPDAARSDGPPRNDGPPRNDGPPRNDMPPRNDGPSRNDGPSHADPGRAEGTSASAGRASDPPVRDDTAGLGPPPQPPCLARSLQALSTPRPPDNLAPGLVEQLPSEVLLCIFSYLDDLSLCACACVCGRWWRLVRARVSPPRWAAFTHKRFPLYRPLLANIDWHKKYQCLVESCFCRNCLVQMCVQAQPAGEENAWRRNRLRIELKMLRNDPPEGIAATPLDPKCCHWQASVTGPIGSPYEGGVFYLYIQVPYAYPMSPPVVRFLTRILHPNISRHGDVGIDSVHHNWSLALTISKVLISIQSLLTDPYTAVCMEPELGEMYVRDRPRFEALARNWTWRYAMHDILSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSJ0</accession>
    <name>A0A835GSJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="969" mass="111601" checksum="4A6FD14CF100186F" modified="2021-09-29" version="1">MSSKEAKWGCCNAINVPDEKSIACSICGKLYHYGCVSLTESPSKSAVPWKCPACLICSSKSGKKDSTPIRNISTTRGNKRAAVGPPSPSSKSPSPVSALRPQGNEELQCMIQEIMEKELNKLLIKFNKMTESTISKELQNVKKDMQEIVESISFMNDRFEKFESNLLSTTALVGRLESENTALRNTVSDLTMRLTNLEQQSRANNLEIQCIPEKKTENIYEIVTKIGQVVNCKIEDKDILHCTRVAKANPSNSRPRSIVVQLSSPRLRDQILASTIKYNKSSKEKLNAENLGYIGHKTPVFIAEHLCPTFKALHAACRIKAREKDYNITMGKTRKKLTREEKLAKDRIRKREKYAQIKNNPELYSLQKEKERNRYLVRKEKNKICSIKDMTPRAQREQRKRWRKNSQNYLKKMEKAKTLERILVENSPPQSESNFCVNAEPQIPDPLTVAEPGPSTIKHSKSTQLAKFNNILRRIRYNHMKTVKILNGRIKKLEREKDVLRKRSNITQKVCDTIEKKVDEVLTEIRPDKKEAVKKQLLFSETISQNLQNTYKTMTKKDKRNFVDTVIKDDTKLRKYKLLHKLPFSRRKKKTATVDNKQILLNKIHSFFEEDTNSRVAAGKKEFIKKHGVKKQKRYLNDNLKNLHEKFLKERCSMAQTAVPYEIVHFLSDSPSSQYRNKTIFYMITKLEDINPNIRRVTWNYQESGHGKGAPDGIGAVVKRTADNFVKYGGDVGTYEDFWALVTKNIPNVYFDMITERDIEDKIIPPNIPGFKGTMKVHQIIWTADNKKTITLRSLSCFECQDCFIPCQHNKHLGYLNSDYYGETECGQSRDQCSENEVTCFKDNQSICSIDTSTILNNLNLDESDVLKNFKSLEGPIDLQLSPIPNTSTSSTVTRSPKIKILSDVRISWENRKFYKMAKKNLAPKKLMEEVFISEHQREFETFIQSNVPEEQELDNYEKSDNSDELNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSZ8</accession>
    <name>A0A835GSZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSZ8"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="23581" checksum="2FCE94E5B08E2813" modified="2021-09-29" version="1">MSSLKLQKRLAASVMRCGKKKVWLDPNEINEIANTNSRQNIRKMIKDGLVIKKPVAVHSRARVRKNTEARRKGRHCGFGKRRGTANARMPQKELWVQRQRVLRKLLLKYRTAKKIDRHLYHALYMKAKGNVFKNKRVLMEYIHRKKAEKARTKMLSDQAEARRNKVKEARKRREERIAAKKEELLQTFAREDEAAVTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU18</accession>
    <name>A0A835GU18_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001497</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000025">
        <property type="entry name" value="serine proteases 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF134">
        <property type="entry name" value="AT07769P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="9" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032285122" description="Peptidase S1 domain-containing protein" evidence="13">
        <location>
            <begin position="18"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="62"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="341"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9422954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="574" mass="60483" checksum="AB94CDE4EF3044F4" modified="2021-09-29" version="1">MKLLVVGLLALVALSAARNIDIENVIDLEASPVFGYHEKVGAPLAEKIRKAEEEAALNPSRIVGGAPARLGQFPYQAGLIIILPLWTSACGGSLLNSRKVITAAHCWFDGQTQARSFTVVLGSITLYSGGTRLSSSNVVMHPNWSPSLVRNDIAIITLPSAVSTSNNIGFIALPSGNEINNQFAGFTGTASGFGFTRDVITNAVCSNSLFWYVQPSNVCTSGAGGRSVCHGDSGGPLVVTSNNRRILIGVTSFGHWDGCQSGHPAAFARRMHLFASIDKMKVLAVTLLALVAVSSARHIDLEDVIDLESITAYDYFNKVGIPLAEAIRKAEEEASLNPSRIVGGSTARLGQFPYQAGLVIELAGRTGVCGGSLLNSRRVLTAAHCWNDGQNQARRFTVVLGSVHLYSGGTRLSTSSVAMHGSWNPSLVRNDIAMITLPSAVSTSGNIGFIALPSGNELNNQFVGATATASGFGLTRDGGSVSGALSHVNLPVITNAVCRNTYPIYIQSSNVCTSGANGRSTCQGDSGGPLVVNSNNRRILIGVTSFGHRDGCQRGHPAAFARVTSYISWINQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUZ2</accession>
    <name>A0A835GUZ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUZ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="648" mass="71463" checksum="B3D097E63C123E4A" modified="2021-09-29" version="1">MMFSDEEIKEEIKEEMPDRGFMQPGDEIISIREVCLSDKFDFKVDKKDLGFSGEPLLSTSSRNDLDVPRSLFRDGFFSDGLEQQQARFAWTEEDGNIASLVSEPGFGTTGQTTFGKDLDAALKSEMKEADTSSAVLQSTNRNGITFSKKIFGEPHLVSSTSAGTSGTVGTDRGKGPGTCKVDKADPRSRFHFVKYVKRHGRTVKLWECGICSREFQHQYTLMRHLPTHTDERNFHCVCNKTFNRVSTLISHRKTHSDEKPYRCHICPKGFHQKGNLRNHLFTHTNERPYRCNICLRGFNQQSNLVCHKNKAHPDDSNCPPVNVRGRSTTPRITRSVTETQPDTTRPQVEHCEVSSSVGPYLPSMSSSVEGPSSSTWTTKDPWELPKPYFEPGDIWNEGPWASMSSGVIVDPIKTYHMGVALATRQTPFALLKPDNGTPVLVKVVDTKLPGGKQMLVPATAEDLRVGGKIVLNNDTEDGVAPHGNIEPKTEANGAVQIRVPVVATVVPRIKPGGRLQLTVEEPHHAYHTALSADVGEVNVEPCTSRNDLRIGAPSTLTHPEPRRLDSCSGFDDGLRTGTRISSTCALPPPAPSPPLDLISMDLFEPMECIAPLGPQITAVDNIDQGPPSDDSDIFIGEFENCIMLSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GW20</accession>
    <name>A0A835GW20_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000532</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GW20"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="285"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9424393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="496" mass="58136" checksum="C775CBD5AC9E6608" modified="2021-09-29" version="1">MLRHETLEKQFDNDEYANETKAKEHIVMLSSSGAGDSVMQIPGQLVTGSRIRDHGRPPMSTPKHLGTMPRIIIVCGYAYFLIQYLIISLKPVITEIDIEYVYRMPHTMNKHNKMLTTHYNVSTYIKSYKRPERFKTDIKFILKFTATFLNYGTPLFKNGQSPFIESNCTYYNCYLTTHRTLFLDIRAFDAIVFDVENYWNGHVVIRHPNQKYIFMASESAANFPLCDAMYDNFYNLTWTYKLDSDIRWTYITIIDKKGNFVGPKINMTWIYPMKATPENVKKKISGKTKAAAWFVSNCNAKSGRQNVTKRIEKELKRYNLTVDIYGWCGKKKCPKDKFEECMYLLESEYYFYLAFENSICEDYVTEKILYPLQNYAVPIVFGGANYSRFLPPGSYINAREQSASEVAYLIYKAIKNPKIYEDYFRWHNYYEYVKTPPEHDVCKLCQILNEDPGQHSSYKHFRSWWNPDHPSLCTKGVGKFIAMRPNSDTLAEIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0P7</accession>
    <name>A0A835L0P7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0P7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052865">
        <property type="entry name" value="Zinc_finger_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47241:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47241">
        <property type="entry name" value="FINGER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="449" mass="51451" checksum="56B2BE1C450B00F5" modified="2021-09-29" version="1">MKNHLKAKHPDKFSEIYGVGFNRLMQKAVPRYKLPSRTYMTEKIIPDIYDRIIKKIMEKILNAAAVSITSDIWTCDHNNESFLSFTAHWISPDFKLEHGQCIILLKPFEEITKITSSGLSCISEVIPHVAVLMRYIQKEETSRKVPNLLQFLTSLKTQLQQRFEHLDENLKYFLATLLDPRFKTNFFGVIQAEKARQSLLLEGLKLSCGEEDASSKKCKRSVSKEDNLMKPFMIVSCDGHIIDAVAPYAPTQTDAEIMTHLFENENGPFRKLFITTIANMENSPFNRSSKTSRSPPSTPQPKEYAADEPIEALSTSDIKDMEGTSCLNCGISSRRERRYMIAQIGPEIIHRLHQWLPQQEFSDKDFLCNQCMNALQRSLDEAESSQSQQQLGHQHVCVWCGRSILRIRSNALRENAPERILIAARISPRQLPEEPRVCYACWVAAKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L114</accession>
    <name>A0A835L114_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L114"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="2">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51072" checksum="13364E8EFEE210CB" modified="2021-09-29" version="1">MSSGRYCCVPGCKERRAPLTPPSTTSLQQLNLGHGPSPSSLTATMQEAALPSTSETNVHLNLGEKTTVKKAKSRVFLTNTEKYLQDKLVAASIKLSKMKNRFKKLSVNVKAAKQIASNPAAISYTFASSATKGPERAQQIKDVIRGLQESGFIVVATVCDQGPNNRQALKLLINENRGIYLRKGKNILPAECKDTADLLLFMDNIFDSVNGSRQKNRNAKPLLGPATPNSAHHQIWIEGVQIFKSMKFVSNGKKQSVPSITNWVWTLSRINKLQNEFNVSSVWLHLNQDPLENFFGAVRSQGCRNTNPTCDQFESAFTTLLINNISSVHTRGNCEKDFCDALYSLTINENAETTSTCSSFDFSNIIEFNFTPIEIKERDPRIVGPLQYISGYFLKKIKSKIFKTCTDCCNLLMEKNEIEYIKYREYAGRRWLCTPSKKLIELISNMQDLIKQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1L4</accession>
    <name>A0A835L1L4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000963">
        <property type="protein sequence ID" value="KAF9404495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1L4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="371" mass="43413" checksum="3415B89057C9A108" modified="2021-09-29" version="1" fragment="single">MDAGEYDEVRRRQPETPVRRSVQLEGRSTRARDDERRSRSRTRHEGRRGSTHHLRSRSRSTRGAGGGRHGHSRSRRRESYEDDDLRQKLRLLEDQLLKRNEQRRRDEATTNYRRSTSQARKIYTPPSSDARSPEHKKPTYSDQVNFFEEFTKFFKGRDRESFLSSSMNNVIPEFDPLLREQTIIDVWLNKVDECAEIYNWNDKQTAHFALPKLTGHAKTWYQGLPSIKHSWLEWKRILQGHGPGESLELYYFSKINLLNRCKIFGKQGVDCIVFGIEDKGVRLSAQAGKFDKPEDTLEFFKTVKNYQPRDLRDFRRDTQSKDTRPSSATSIAPRVNGSVRSQPKGNLTCFNCNDPGHMSWQCRKPLNKCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1T3</accession>
    <name>A0A835L1T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000324">
        <property type="protein sequence ID" value="KAF9409332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34008" checksum="71E00FA7655A51DC" modified="2021-09-29" version="1">MCSSTILSFLRQWRLWIRPFLIALYVVFIIVLVPILIAHSINNGFKKSDQGSLVGGGFVLLAVPISIWQITQHVVHYTKPILQKHIIRILWMVPIYALNAWIGLEFPEQSIYVDSLRECYEAYVIYNFMKYLLNYLNEDHDLEALLETKPQVYHIFPLCCLSPWEMGSQGVIINILVYCGVISTIFDISDSDKIKIMSSKLQTLKNDLETIGSSFSRRLRGKSMYQMARGYDESSRLVSEQAIPSSSAPNLTVDTEPPAVEVRPSVYGSLDNTMSAISTNSETQPLLDYDEQNQNDPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2H3</accession>
    <name>A0A835L2H3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_015248</name>
        <name evidence="4" type="ORF">HW555_009434</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000209">
        <property type="protein sequence ID" value="KAF9411899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000724">
        <property type="protein sequence ID" value="KAH9632216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2H3"/>
    <dbReference type="OrthoDB" id="7474542at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9632216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="12226" checksum="B3C5C713797413C0" modified="2021-09-29" version="1">MSDDGSTAVEKKGRGRAKANGTQSEAKGDTKKRGRPPAAARTKESTKSSDDEQAPVAKRGRGRPKGSKKKAAAKGKSAPVEGRGRGRPRKDPVKDAASTDEEQDEDYEDEGSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2N8</accession>
    <name>A0A835L2N8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_011369</name>
        <name evidence="7" type="ORF">HF086_012307</name>
        <name evidence="5" type="ORF">HW555_007428</name>
        <name evidence="4" type="ORF">HW555_009985</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000126">
        <property type="protein sequence ID" value="KAF9414732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000369">
        <property type="protein sequence ID" value="KAH9638814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000175">
        <property type="protein sequence ID" value="KAH9642813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2N8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9638814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9642813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="451" mass="50689" checksum="1FA7B824238DB4B6" modified="2021-09-29" version="1">MPNSHRRRGRSVSRESRHHRRDVRSRSRESRSRGRISRSRGRESHNSRLDLQGNRIPRQPDIASNSLLTQQMQQILDRLTSLEEDRRVSRAASLRQPSNQQQQLVEETATTARDGAGFRDSAAPSSPGRSVSAAADRDATVTDRLIDAIRSINTTVRSNQAYFISNFDPSVNDIDTWCEEVDRAKVSNNWTDNECLSRIGNCLKGDSKTWLNEWVTSDRTWSNFIREFKPLCPRKPDVANILYEVMSTNSDRYPTYADYARRSLLRLRIVKGLSDELISAIVIRGVMDPQIRAAATNAKLMPNELVEYLSIYVKSNLNSKKYTNPSNNDRSFKSTLETSQRKRKFEDGTCFLCGKYGHKSSNCHKRQAANSSNNSNGNVQRNYPVSSSSADSNDDNAESTPEQAANVDTQPTIDTSPEPMPSTSRAAEALQPQPQENGDVLQSGEAVLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2W0</accession>
    <name>A0A835L2W0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000156">
        <property type="protein sequence ID" value="KAF9413523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2W0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="550" mass="62959" checksum="A3A52EA2458D76DC" modified="2021-09-29" version="1">MVGAMPVNLIPKFCNGTMDSHNGTEDSEIQVHIGSRVKCNDDFGTVKYIGEVHGYKGIWYGVEWDDPARGKHDGSVDDVQYFKASKPGAGSFIRPNKISPLKTCAEAIRKYYGDREDETVAAHRRTVINEWKREMGAPFIEMVGFEKIHQKQNFDRLLEVCVHDQNISKAGEVASLCPNVRSLDVSRNLFCNWREVIQLSAQLPDLRELDVNKNRMAIDMPEETLAQLSINFANLEKLNISVCDYEWADILALSHLWPKLNEMIAAYNRIKTIIPPTVTLRTLTVLKLDGNPLASWYEVMNLGTMKNLKVLSLNDCQITEIRFNDNPDDKVDLFEKLEVLFLNRNRINDWRSLSELNKLACLKKLYFLKNPIQESEDYDTGSQLVIAKIDTLQELNGSTITRELRRGAEYDYMKRYGAEWKLAQNDPVSQRAFSVEHCRFTELINKYGIPDDSLLVKQPKTMTLTSQLLEIILRDENGKSFKKKFPSSMFVQKLVTLAQRLFPRPGHTGPPTLYLLDDQMQGAEICLDNVMKDLAYFSVKNGDIILVKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2Y6</accession>
    <name>A0A835L2Y6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_010694</name>
        <name evidence="7" type="ORF">HW555_008223</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the insulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000576">
        <property type="protein sequence ID" value="KAH9635011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2Y6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04366">
        <property type="entry name" value="IlGF_insulin_bombyxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032871970" description="Insulin-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9635011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9079" checksum="4A962D2982CCF86F" modified="2021-09-29" version="1">MMKLVVVAVVLACCACVCSAQVRGGVHCGRELSETLATLCWGPELSKRSWWVPPAGALAGVRGKRGLVDECCSKACTIDELMMYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L323</accession>
    <name>A0A835L323_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000545">
        <property type="protein sequence ID" value="KAF9406824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L323"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF3">
        <property type="entry name" value="BETA-HEXOSAMINIDASE FDL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="406"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="557"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9406824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="923" mass="105963" checksum="8F70C0CF111C4114" modified="2021-09-29" version="1" fragment="single">INKCVHPKSPVKQLNIKSLVRILNKYKQDIYGRKVDKAVLDADDIQTLIKEKCFWDLKDIPNKMYVMYSIMLFHCCVNSDEGNVDKEICTHLTKKEQDMILKFCERLADMEITASNIQCAIKDAYGLVNSNLNAKKEIKNAGTHKKLQSESSAPTTSPDKSSFNTVTTANTTIKKDESELSEDLIKDSNTLKFKSSVTLMPSAIPDTSYSEVDYVVNYTSKSDVTEKEPFDKAPKVQLHVHRYISRDGNVATDSCEMRKRCGMNCACNKCSRNLSCCGEPARSSLFCQQEYKAYRCGEKKNLFSSFPCELECKWKIFLTIVIILLLIASAIAGFLFLPLPFDSDLDESTSDKIEEFRMSGGQEARMFQLNAYVCKNGLCEKLIGPTSDYFFSSLSRCTLLCTGPQIWPFPIGYTYYSKKIVSLATSRLEYKFNSVPSEAVHIYLAEAFKLFLGDLAKLEQYTSDPRNLSSENKIVKKMSIEMDVETDPDPRLRLDTEESYQIKIDTVNNQVVMKLLAASFCGMRHALETLSQVILLDQTTGYLITLSNMVIKDAPSYKYRGLMLDTGRNYIPIPDIIRTIDAMAYSKLNTFHWRISDVTSFPLYLPEIPQLFEYGSYGRNYKYTKEDVRAVVKRAGIRGIRVVMEVAAPGPVGRAWSWVPEATCPSKNRNFTCSNILCLRLGMRDSVFDILQIIYSEILKLTKIEDVFHMSDSIFSLANCFYLVEEREGFLEKALERLKIANRGFLPKLPIVWYSTHLTKDYEARAWDRFGVQLSEWQPNPTEQFLSRFKVIHSSRWDLSCEMKKHRCKRYRTWQDMYSWKSWRNIDVFTIEGGESMLWTDLVDSGNLDTHLWPRAAAVAERLWSDIALNGTVSGEVYVRLDSQRWRMVLRSIQVQPIWPLYCSFSPGVCLEKIRRKEVVQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3C1</accession>
    <name>A0A835L3C1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_009678</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3C1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="15">
        <location>
            <begin position="54"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="14">
        <location>
            <begin position="271"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9411606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="629" mass="69537" checksum="86C631B3F833EC12" modified="2021-09-29" version="1">MLHFNTVPEDYVRKTNQYAQVALACGRAAHQTAIRGATSPNPQLAALTPKVRAFVERSAALCQPEHVHVCDGSEAEASALLHIMQQQGTLKRLPKYDNCWLARTDPADVARRKRDVVPIARAGQKSALGNYIAPDDYEKAITERFPGCMRGRTMYVIPFSMGPVGSPLSKIGVEITDSPYVVYSMRVMTRMGAKVLEALRQDEQFVRCLHAVGTGGGVAGWPCDPPRTIILHKPADNEIVSYGSGYGGNSLLGKKCFALRLGSVIARREGWLAEHMLIVGVTDPKGRKRYIAAAFPSACGKTNLAMMTPTLPGYKVECVGDDIAWMKFDKNGVLRAINPENGFFGVAPGTSEATNPIAMSTVFQNTVFTNVGETSDGGVWWEGMGAAPEKLTDWKGQPWDPSKKTPAAHPNSRFCTPAEQCPIIDDQWESAEGVPISAILLGGRRPAGVPLVVESRDWQHGVFMGATMRSEATAAAEHAGKVVMHDPFAMRPFFGYNFGEYLKHWLSMPQAGRQMPKIFHVNWFRKSDEGKFLWPGFGENSRVLDWILRRCDDEPCYTESPLGNIPAEGDLNTQNLGPIDMKSLFSIPKDFWLQEADAIEKYFKEEVGQDLPQEMWDELNKLRNNVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4C5</accession>
    <name>A0A835L4C5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="326"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="821" mass="90959" checksum="C6BFDF57C52DDDAF" modified="2021-09-29" version="1">MADLMQRLRELGRKKDVNLNNSVYSVISCSDLTPGSVDIWVDLPDEIKFDPLLAPFKQRYEQQHGKIESEEPTEGDKTIFDKKHEVDTKKEDAEPLKDAANRLMDPMQTKDEKKLKSAKKKRLDQALRTVKLCALISCWVLLTVSLLMNMERSDVVLHTAVQGGEIKEYVLPASEHRVKVSITLTGPFAQPVTNDSVNSLHLWLHRSVGDNTTAEFEQNSTKWSIHLQPEDILDFSPSSTESRLLILEDQAPILTRGHHDLNTSSHSLITEEITRWGQIGMNGTKLTLRMSSTSSSIVPLTVSYQMNPIDPEDGIIYATILLITLYTLIIFEIVNRTIAALLSSTLAVGVLALCGARPTLPELVSWLDVETLLLLFSMMLLVAILAETGLFDYLAVLAFEVTGGRTWPLINVLCFFTAIFSTFLDNVTTVLLMTPVTIRLCEVTQLNPVPVLMSMVIFSNVGGAATPVGDPPNVIIATHPSIVKANINFTTFTIHMGVGILIVCVQTYFQLRYMFKDINKLRHSVPRDILELRQELAVWRRAAASLSSYSRDEDIVRRALEKKVEKLNMALNRREAGGGASRTDPMFCSTLAQMKQKYRIRDKPLLVKSTICVSFVIIVFFLHAIPELQRLSLGWTALLGALLLLLLAERADLEPILARVEWSTLLFFAALFVLMEALSKLGLISWIGSMTENVILQVGQESRLTVAIMLVLWVSGIASAFVDNIPLSTMMVRVIAALADPAGLGLPLAPLAWALSFGACLGGNGTLIGASANVVCAGVAEQHGYRFTFLQFLKIGFPIMLGNLAVASLYLLFCHCFLQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4N5</accession>
    <name>A0A835L4N5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000118">
        <property type="protein sequence ID" value="KAF9415083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4N5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19598">
        <property type="entry name" value="serpin77Ba-like_insects"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF367">
        <property type="entry name" value="GH21475P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032886227" description="Serpin domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="29"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="44253" checksum="3775FA28BBFF2704" modified="2021-09-29" version="1">MKAVALVLVFVGTCYCQVEFNERPRNFSIELLYYTQAETDGHVVISPFGIWTLMTGIALGATGNSYNELARAFILPRNQNTLIKGYKDLTNAVLAQGNNGVSLTSRNFVFLDNDFTVFPAFRGSLQNDFGASLKVLDFDDPNSARIANTYIEKSGGRVSNVLRSDDFQESRMILTNVISFKGLWASPFNKSDTVLEPFYDEDKNVVGSVNMMFQKGQFAFSNMQSLKSFIVELPYGTNGKYSMIVILPYPSVKIADMYKNFAHVSLKDVFKRLQDDVDSFGMEDVDVKIPRFHISTNLVLNRPLNSMGVYDIFQPDQASFQQVSKDNIFVSAIVHKADIEVTESGTVASATTTATFSDRISAPYFHANRPFLYFIMEKTTTTVIFSGIYSKPTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L527</accession>
    <name>A0A835L527_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L527"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="547" mass="62288" checksum="8ED87EFBDB544F3F" modified="2021-09-29" version="1">MMIEMTMKIFCLHELAGAASDSDSDGSRNGMPDRRPADLKKQQIITDIENNYVLDTNVDIGVAGELVEEVAEENKSLLWFLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDNYYHADILAEAQQVEDPYQRFVAVLRWYLSGLYRKPKGLKKPYNPVLGETFRCCWRHSPESYTYYVAEQVSHHPPVSAFYVANRKEGFVIEGSLLARSKFYGNSTSAILEGCARIHLLNWGETYVTTAPYAHCKGIVHVMCAETGYHADVEFKLRSFLGGADQTNAIQGRIKRGKETVAVLEGYWDGKIDIKDKRTGEESNLFDVSLLKEQRLPRYLMNMDKQQEFESAKLWIKVSEAIQNEDQVAATEQKTLIEEAQRARARNLVTPWVPRLFHRNLQAVPTDGVVDQGWVYNHININPWAPDEVMEYEEDFVIKTLREGAAPVKPAADIRRDLARRMSDTDSHDELTRPKTSARTLKQSLYAIDTALREQTLAIERLSKSVETISEGQRQAAAFRPQNVGRVPTSSHSWDLFGGFVLAMVLQALLNWVFYQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5S0</accession>
    <name>A0A835L5S0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5S0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="228" mass="26480" checksum="7168A39A3234AB90" modified="2021-09-29" version="1">MVSVLPRRTMKAALRLKEQEYSIKAPWGNIAGKIFNIAYPGHITRVVELDPVPAHHTWPFTREGLHDWYHSYYMMYNDERFHKFNSGLDTAPKYSYEKAQQLMMQTRGLSKEATEHVLERCLVPAGDGLYRFTFDQRMKEVSVFPFSGEMLRKIYTTTTTPTFCVLAKKMIELGVYEPVPFVMDEKAWPHGNYKYKIVEGGHDVHIDNPEYMADDISNFILEGTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6D2</accession>
    <name>A0A835L6D2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6D2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052644">
        <property type="entry name" value="ZMAT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="2">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="2">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="389" mass="44429" checksum="55129EB70D03F558" modified="2021-09-29" version="1">MNYDDILKDDVCVGLENDDFSEYLNDEDEKAGNKKGNYTRNDSSYGGKGSGNYEADDYGPSGHEPQYTWGRGFGPNGPPFPTNNTRHNPIGFLIGCGVPRQSLRGLPRALLNLMEPQFCGVCNVKLENDNSTRLHYISKNHTRKQKTWLTQQGEHGPQRPKESAFKARELYCELCDVHITSKSHADSHYSGKAHRGVVEGRREIKNRYLLQRGMEGRLNSLIRREKKYLKFIVANEKSTPKPEPVKEVVLPDSELCCKICKITVTCIEQMTSHMNGKKHLSKEKQHILKMMKGVPENTSKFLTHSVPSTHYINVLNAQALKTRTLLMSLRKITLPKLQKLRHNMRVKMMIGVMEMAPGMSENTQYRLEEFTLWCAFTAAVFWKSAFIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6Q3</accession>
    <name>A0A835L6Q3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">ATP-binding cassette sub-family B member 6</fullName>
            <ecNumber evidence="30">7.6.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">ABC-type heme transporter ABCB6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="ORF">HW555_002819</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="45">BAW_Kor-Di-RS1</strain>
            <tissue evidence="45">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66768"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167478"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66769"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:66681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:19262"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58687"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:61361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61336"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:61337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167480"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:66773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66776"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167479"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:66777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Melanosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="45">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.5" evidence="30"/>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6Q3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18581">
        <property type="entry name" value="ABC_6TM_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000022">
        <property type="entry name" value="ATP-binding cassette sub-family B member 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032410">
        <property type="entry name" value="ABCB6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16185">
        <property type="entry name" value="MTABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="27" id="KW-0458">Lysosome</keyword>
    <keyword evidence="25 42" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0964">Secreted</keyword>
    <keyword evidence="21" id="KW-1278">Translocase</keyword>
    <keyword evidence="15 42" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22 42" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="44">
        <location>
            <begin position="249"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="43">
        <location>
            <begin position="573"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="41">
        <location>
            <begin position="814"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="41">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00024320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00024385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00024439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00031413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EMBL" id="KAF9421107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="846" mass="95932" checksum="2075F7310F7E9E2E" modified="2021-09-29" version="1">MMEYCPPNVTLGEIWVDHGISQCFMETASAIIIGGFLLTLGLIQIIMYKRYAIEVEDIRSSKLFGVQLFFTLFVPVLAVIRFLLQAFVFKGGQIYGYMILALVITLVVFPFSAYLAILERRFLLPSVPPSGHGFILLVFWAMIFVSENLSFLNLNKEGWWWNLKTLQDRLEMSLFVGRYVSCMIMFVLGLKAPGIVQYHYLGAEDENRRNIPPRQDENRSTFRNVFSKLRTLLPFLWPRKSACLQIYVLICILALLAGRVVNLFVPIYSKKIVDSISLPPFYFRWDLVVIYVFFKFLQGGGTGGMGFLNNLRSFLWIKVQQYTTRELQLELFKHLHDLPLRWHLSRKTGEVLRVMDRGTDSIDNLLSYILFSITPTLVDIIVAVVYFVSQFNVWFGLIVFSTMVFYIIATIAVTEWRTKFQRRMNLADNEQKARSVDSLLNYETVKYYGAEAYEVVSYREAIVNYQREEFKSLITLNMLNTLQNIIICSGLLAGSLLCVHMVVETNELTVGDYVLFASYIVQLYVPLNWFGTYYRAIQKNFVDMENMFDLMRVDSDVRDAIGAPDLLVRRGAVEFKHVSFGYGPERLVLNNISFKVPPGSTVALVGPSGAGKSTIMRLLFRFYDVNEGAVLVDGQDVRTVTQASLRANIGVVPQDTVLFNNSVRYNIQYGKLNAPASDIISAAKNADIHDRILTFPDAYDTQVGERGLRLSGGEKQRIAIARTILKDPAIVLLDEATSALDTNTERNIQAALARVCANRTTIIIAHRLSTIIHADEILVLKEGEIIERGNHETLLAQGGFYASMWQQQLENRNNTENIGEGNNNNNEPRPPPGQPNGAFGHGHGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7C3</accession>
    <name>A0A835L7C3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="3177" mass="375027" checksum="609C0F9D3D0AE270" modified="2021-09-29" version="1">MLLTIMKSLTLEGETLGEKRRHFNKLVADAVASKRYELTPIDYTDSDIDNLLKIEIACKTRNVDYVIEVMKSKDMLFASTAIKKSTWLITDPQYANIINPEYLHTQLKPYMTTKAFNKLILHIRLNLKDESRVEAFYEHLKSTRNSEKWLQNCSIPFIENAISFIVPVWFYRRLLKKSAHFLTFDTYIDAYREERQAAYLMLKSRTADVLDILEDTTEFLMKKCPQRVFENIKMYRWAIDMSVIARYMNKNEIAAFLCKNASDMVFCHDHKILIHFIKNMPEEERVKFIQKSFIDRTEMLFDKNEISFIDSSFRYYQWYEFFPFEIAFPKMNNLIRKENLPMGVYTETENDFQLCWESIIIRKVLTDEPVPESIEEKCTFRSFKNISKTLNVEQKNKFITYILTYMTARTTSEGFASESDFRDTLNKMESVLILLKDFNKTLSDYPFITKKIQDLNKIRQVNKWFVDMSCLYNVNKSWRKYMFEDSLSLSLCEETCLNALKHKPQLLTRHDKQIYTLQTNDAVSLPRVLAKLRVYWPDSLAWHWSKAYMQHLNGPTGHKAIIKGLFMLLSQDQVIELAKRYAPKNFKINWCLTDRTKINIRINIAKHLHLARPLVPLETVLWYAKGDYVQYAMQSHIAIWSALSEVDMGKNLSKFYDAPVIVLKFALNQAFLKLKTNNVINIFLYIWKCTRSSLIKSIILNRTKYATQKAHDNEIIQNELWKLLNMFIKDLSSEDESADIYKQLTDFEIVPYEKQAEYYMKISRYLASLPDWQRYKDEILYFSPRHMKLLDEDFVLNLLLSPVENIFCSSNRLILECFSNFLLYGKSEEDQLEILRKVEPAFDKVFQNWNKTNASKKNFESFLDIASLLFKNGNWYGMSMLIPAKLFAEIEFKMKNGLSLLENYKLFTTWKLITAYIKIFKLCEERRETGDKDYDRDFSPLLSSIILEYLKDDVEEYGPMIHDMFAAALDKMCKMLFIHNYLIIEMLRHMLNDEGFVPACLVVSKILPKSVHEETKHAQSEIFQKLKSNEDTFGEKRRKFNKLVADAVASKHYELTPITDTDSDINNLLKIEIACKTRNVDYVIEVMKSKDMLYTSTAIKKSTWLITDPQYANIINPEYLHTQLKPYMTTKAFNKLMLHIRLNLKDQSRVESFFEYFRETDGACKWLQNCSIPFIENVIKKRPVPAWLFKRLCKRSARFLGLYAYVEPYEGKAEQASKYYTYIVFMLKSHTEDVLKMIEDQRHTILPMLGKRKTEILLKKFKQRVLGNLDRYLAMLDLSTFTKCLQKNEIKTYLYKATKHVSGHVRDAFGEFDTWKYFLNRMPEEDRLKFVKNVLIDKNEIELLLNGQQRHEIGERIKSHQWYEFFPYDEAFSEFKNKMCQQSKPSERWGMLSTLILCAKSNIDNTKSLVKYVAENHINEPFKFKKEFVNTLLSNVPIHEFDIETWNYLNQLFQSMEVYVESKKRKMQLSLQAVILYNVLHNKPIPEIIQHKNTSYDFTHVLKTLNEAQRSKLFTYILGTVCSKIKTDNIVNEADFNETLHEIEYVLILLKDFNKKLNDYPLKKMWTTDMSCLYNVNKSWRKLMFEESLSLSLCEETCLNALKHKPQLLMCHDKQIYMLLTNNAVSLRRVLAKLRVYWPDSLARHWTEIYMQSLNKPTDHKAVIEGLFILMSQNQVNKFASEYVPENFKINWGLTDHTEVNIRKNIAKHLHVARPVVPLDTVLWYAKEDYLQFTVPSLNAILSNLSEFESRKHLPKLLEAPVSLSKFGLLVVSLKFETDEIIKIFTNVLNTTKNPSLKFVIFQRTYNKIREMKNSPAVKELWKLLSLILDDLSFEQKGNMFMKSYEFFTTLPDTHDNDSYLYKLLQCVPKVMESLDEDFVAEKLLVPVDTKFCANCCNHIESYACFVLFGDSEENQLVRFKRVLHPAMKEAFNCWQNNFYGTFYVQKQFNQLLDLLGWYFRVYFTLNKIRIPAILFAEIKTTLEQGLPEVKDYVRHTSWKVVTEYITLLKDNRSVSDAFKDAEMIWKDIHCKLSPSFGPKIVNFLKEDSERYSPTVFNLFADAFERSFEILGFRNNDFALETLKYMLDDQDFIPIYLVVSKIVAKYCANYDAKPYNKSLMSEILEKLKSNPSKIVKLEGETLGEKRRHFNKLVADAVASKHYELTPIDYTDSDIDNLLKIEIACKTRNVDYVIEVMKSKDMLYASTAIKKSTWLITDPQYANIINPEYLHTQLKPYMTTKAFNKLMLHIRLNLKDESRVEAFYDHYDDIRIKDKWLQNCSVPFIENSISHYVSLWLFKRLCKKSNHFLTCTSYVAGKRKNGAVYLTMLKSRTADILHIIEDKKAAHFISAIGKKRTEFLMKTCPQRILKNIKMYRWKIDLSVVARYMNKNEIAAFLCKNASDMGFCHDHKILIHFIKNMPEEERVKFIQKSFIDRTEMLFDKNEISFIDSSFRYYQWYEFFPFEIAFPKMNNLIRKENSPMGVYTESENDFQLCWESIILRKVLNDEPVPESIEKKCTFRSFKNFSKTLNMEQKNKLITYILTCMSARTKFEGFASESDFRDTLNKMESVLILLKNFNKTLSDYPFITKKIQDLNKIRQVNKWFVDMSCLYSVNKAWRKYMFEDSLSLSLCEETCLNALKHKPQLLSRHDKQIHTLRTNDAVSLRRVLAKLRVYWPDTLARHWTEAYMQHLNGPTGHKAIIKGLFILLSQDQVIELAKRYVPKNFQITWCLTDQTEINIQINIAKHLHLARPLVPLETVLWYAKGNFVQYAMQSHIAIWSALGEVDIRENLSKFYDAPVLVLKFVLNQAYLNLTTNEIINTFLKIWKCTKSAGIKSIILDRTLNATEKSYDTEIIKNELWKLLNVFIEDLSSEDENADIYKQLTNFKMFPYEKQPEYYMKISRYLASLPDWQRYKDEILYFSSQHMELLDDDFVLNLLLSPVENIFCSSNRLILDEEFQLERLKKVEPAFVKAFQNWYETNAYKKNFKRFLVIATLLFKDSNFFGKKMLIPAKLFAEIEFKMKNSFSLLENYKLFTSWKLITAYFKILKLCKESHVGEDDSNFSLLLSSIILQYLKDDIKEYGPMIHDMFAAALDKMCNMLFINDYLIIDILRHMLNDEGFVPAWLVVSKILPKRVHDEETKHAQSEIFQKLKSNVSISVQVQFNNDFRDYLDEECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7P6</accession>
    <name>A0A835L7P6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7P6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="16023" checksum="0121EDF39AE752D9" modified="2021-09-29" version="1">MSVVTSFINDCYKRIAAGASRSGTHCNKRSTYPSKEVQKTVRALMTDEPTKQVIRKRARAAAKQSDAEVINKAVREMSESSRNGSSLEAIRTYIGAQYKIDAEFLAPIAPASEVGGTGDKSNASEGGAKRKTSAAAASGPPAKRAKTAASDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L846</accession>
    <name>A0A835L846_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intraflagellar transport protein 122 homolog TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_003751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L846"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="4">
        <location>
            <begin position="2"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="629" mass="70549" checksum="505BAD146984C4D7" modified="2021-09-29" version="1">MSEAYSVACLGVTSLDWERLGVAALEELAFEIARKAFQRSENIMFLNLIDHLQERFEAGEKRAVVLGEVMAYRGRYADAARSYRSVGRDDKALNLYVDLRMFNKAQEYVGEGEGLAALARRRAEWARHVNEPRAAAEMYLAAGDVKRAAELMAETGRRDMLIELARKLDKGSSGSLRFVAEALVKAGEPATAADVYQRLGDYTKVAQLAVAAGEWSRAFTLAREHVECKREVYLPYAHRMAQENKFVEAQKAYHMAGEITTAMRVFTILVGNAVAEERFSDAGYLHHLLAMQCLETAAAATTDKERNRSLREYANNDRLARIYHAYDVVHRCVHEPFSLTQPEALLNAARYILALLDVEPPTGVSMFCLYLCLSKQAKALNANTLARQMLDKILGLQIPHKFQESVELLILKTRASTGGESRDDEVAPLCWRCRRHTPPLCATRCPFCRHALAHSLATHEVLPLVQFEPAEGISYEEALDLIERAPLPETTLADNTDYGAEVLRIDHDVDSNDPFLDKVDEDDEVGVVVCSRGALLQLSPASVIIINRPPLRPIMYRNMLPELPATACQHCHKLFYLEDFEIQLVTRGHCPFCRHPAEEPRPEDEETEDSLMNDSSPTPTSPSNDRGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L849</accession>
    <name>A0A835L849_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L849"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000611">
        <property type="entry name" value="Capricious, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032483491" description="LRRCT domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="575" mass="65143" checksum="1BF9F428D50E8124" modified="2021-09-29" version="1">MGSCVAKWRWWVVVVAWAWGTAARTLCPARCACDDALRAASCANASLEIVPIQLNPEATHINLTHNAIDNLLYTFGFYTQLTVLDISYNRIVDLGSRNFENNMEMTHLNLSHNFLKRLDKDTFIGLKSLIDLNLANNEITNIHVQTFKDLSALERLDMSNNKLVKFEPDAFKPLMSLKILSLKNNSILDIPSYNLAFIMHLEVLDLSENLIEQVPKHGIPYLQELKHLDLNNNLIESVDQLGFHNLPSLRHLDLSDNNMTSIPTSALSKLSNLSHLYLSGNFFQNITALSFQSLFHLKHLHLSRLYELERIDSRAFVDNINLQKIWMNENVKVGDVPPRLFHGNPKLTHIYMKNNALVALEASHFPIDRLQELEIAGNPFTCNCSLLWLWKLGRESEISSRKSGNTSSILKIDYEDVKCAAPAHLKGVLFVQIPESEFGCSSGWVIVAVVVLTVSIIISVVGGVLYFMGPLKKCKGDKSKQVMTSVMMNGDVSKLGNGLGYSTRSREQDAKRDVDRYLMIGSSVSNNFHSLNPPWHSVDKNPYYQEDSEEHIYQQFAYETIPHHRTPEKPHIVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8V6</accession>
    <name>A0A835L8V6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8V6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="21343" checksum="CA575196B52C30C3" modified="2021-09-29" version="1">MREKLKYHRLFKKYGNPRDNDTFSLLRSRCKKLIAEDYYVFVSSVESSLEHDIKNFWRFVNSKKDTNAIPQTMTYGNLVSSDQRGICELFSRYFGSVFDSSGVTADGETNGIPYKLDPVYLQPGTRDYKVNIPTLPQCVNREIGVTANICDEDVAPSGTIPEFNTLLVYRLGNYQHIGVVSITVYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9B9</accession>
    <name>A0A835L9B9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9B9"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="394" mass="43473" checksum="169A422169A4BB20" modified="2021-09-29" version="1">MTDEQGYLKPKPGFATTAVHAGQNPDKWNGAVVPPVVMSTMYKQAPEGHKGYVYSRSANPMRDTLQECLAALEGAKYAFTFSSGQGATTSITSLLNKGDHLVSIDDVYGGTSRLMRENLPRHGIDVTFTDITDLDKLENAIQDNTKMVWLETPTNPNCTVVDIAATVQLVKKRGDIIVVVDNTFLTCYLQRPLDFGADIVMYSLTKYMNGHSDVVMGAAVLNKQEIADKLRIIQKSLGIVPSTFDCYQVNRSLKTLSLRMERHKATSLVIAKWLEKQPNVIEVLHPGLTSHKGHEVSKRQTSGHSGVFSFRHTGGLKESRKLLSCFKVFILAESLGGYESLAEIPSIMTHKSVPPPQKAQLGITDSLVRFSIGLEDPEDLIADLENAFKETFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9U0</accession>
    <name>A0A835L9U0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9U0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9422217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="732" mass="83097" checksum="3F1F94823B9EECCD" modified="2021-09-29" version="1">MVEADNISVVLSNTSPKKYLSAYELNGSIHTKSVKDITSTLDKRQFYKVVVNGLDVTPNNIVDPEYVTLNDLTTHAAFDSRSRYKIEGPFKFSRSRSRAGLDSTGTKFYATTINLDDIEIDVSQNTEEGLQTGDDKVSPAPSAFNLPKFPSITSYPPEICITLKETETVFLISLPCLSYEKGSLEGNLTEEDNAFYDYITIGKGKNKKVVHEETQTQIKMVQSRHVLATRPQKKNAISFASVWDMHDTYAQINETVVIEDDDEMVMYDTPASYMLRKKRKKAELEKRLGKTFEEIAATSQYLDAVLLMERVLASLKFAAEQKKFRGLFQMDPLALDLIYIYKMVKLWTYEYEETLNTPISCISYNPKYPSICAISHGKYGYADVCRGIVCIWSSKNPSKPERLYRFKDPVTCVSFSKKHPNWLACGFCNGDVIILDITSYSIKIKAKSKRDTNPCHDPIWVISWQSVEGDSEFVMTTSQDGRIRKFRKTKTHDFISTPLMRVCTVEGKLKGLETTRPCPKHDVPITRYPAVLCMVWHSTIDHCYLVGTDEGCIHRCSMHYLNQHMDVYRAHAGPVTDMCYSPFMDYLLASCGADNAIRMWIEGMDDVIMTLICPGAVNGITFCPINSTILISASANTVSVWDLRRKTHKPCAEYSFPGDVTLTYIRFAPCGHNVFVGDTLGRLHTFHLEDTPIPPFNQKKLLDDVIRKALCTRPHMLKQLDKLLKFKKRKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB96</accession>
    <name>A0A835LB96_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_005319</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9417612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68273" checksum="EE66CA50C3D1881D" modified="2021-09-29" version="1" fragment="single">CKFRSVNAYYIPRWSLSVIVDGRAITHSARHTNKIMTVIYFDWLDYLVFGGMLLCSALIGVYFAFFASKKQNTTSEYLMGGKTMGMFPISMSLIASYISGISLLGLPAEMYTYGTPAVDGSALGMGSYLRLRFNQKVRLLGSIIFIIKMMLYIPIVIYVPALAFSQVTGINLHLITPIVCVVCIFYTTLGGLKAVVWTDTLQTVLMYFGVIFVLAYGTWRLGGISNVISINEKGDRLEFFNMDVDPTIRHTFWSTVFGNYFSWLASCSVNQAMVQRCLALSSLKRARITIFIMAAGIFIIVSLCCYTGLVIYATFADCDPLTTGSIRKSDQLLPYFVMTITGSIPALPGIFMSGVFSAALSSMSTGLNSMCGVIFEDLIRPAYNKPISERAASFIMKIIVVVVGFACVALVFLVEHMGALIQAGKSLAGITAGSLLGLFSMGLFLPWVNSTGALTGGLTSTMLVGWISLGTQAAMMRGDIIVTPKPVSVAGCPGNHTFSTPSTPLHAVEFDRSGTFFLYRLSYLYYTLVGMIVCIIVGSVVSYFTEPNDPAMVHRDLLTPIVHRWLPTQHPHCRRPRLTQHDIELHARELDQLRAHSSYDKMGDSPESMRKNNNNINDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC53</accession>
    <name>A0A835LC53_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-ureidopropionase</fullName>
            <ecNumber evidence="6">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC53"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000008">
        <property type="entry name" value="Beta-alanine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="389" mass="44079" checksum="88077AB1A3B836D0" modified="2021-09-29" version="1">MENETVSLESIINNNLNGRDLEEFNRIYYGRTDNHEVKLKESSIAAAKEADFEIAAYAFPAKKEQTRTPRIVKVGVIQHSIAAPTDRPVNEQKKAIFDKVKKIIDVAGQEGVNIICFQELWNMPFAFCTREKQPWCEFAESAEEGPTTRFLSELAAKYAMVFVSSILERDENHSDILWNTAVIISDTGSVIGKHRKNHIPRVGDFNESNYYMEGNTGHPVFATRYGKIAVNICFGRHHVLNWMMFGQNGAEIVFNPSATIAAEAGSEYMWNIEARNAAITNCYYTAAINRVGYEEFPNEFTSADGKPAHKDLGLFYGSSYFTGPDGVRCPGLSRTKDGLLIAVMDLNKNRQIKDRRCYYMTQRLDMYVSSLSKVLELDYKPQVVHENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCE4</accession>
    <name>A0A835LCE4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCE4"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9419086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="478" mass="53916" checksum="54432024C2268304" modified="2021-09-29" version="1">MGDVGEEKESAASGDNSETKKPEIYTPPEPEPKPPDVELFVDGFGFMPKSKHKKERRRSSVFEKTKLPQQESYDDHSEQSLCASSTNIDIVRRYTWKTKNRMTVQVITYGATITSISVPDKKGVPDDVLAGFDTLEEYFQPGNPYFGATIGRYANVIRDGTFVVRPSGRMYMVSNNKGHNHYNGGYVGFDKVNWRSYVSGLKVIMSHVSERFHEGYPGTVMCQITFEVTCNNTLKIEMKCTTSEPTVINLSNAPFFNLAGHHTGAELMLDHIFTINADKFTAVDEDGLVTGERKVVGGTAYDFRVPRILRSMLPKIPMGGYDINYCITRGTEQDLAFQARVLHPLTGRVLEVYSNQPGMQFYTGNLLPDPDRIVEPVPMSEEEREEVDHSEEMSSESSSVEVEDEEGDEREGKKGYGYVPLLGKKGTMYKRHGLFCLMPQNYPDAVNYKNFPSPVLNPGEEYIHRIQYKFGILLGRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG58</accession>
    <name>A0A835LG58_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG58"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="227" mass="25537" checksum="220BEB47FAE73600" modified="2021-09-29" version="1">MTLENLLSQVGIGTKQLTDRIFNACGTLGIPELLTPTHKFYYHRYSEVPVHDHHVYYAYEPSAPSHGPVATSKYNYGGSHHKSGASMSALTLLAFLFFLHILQQCIKDHMTEMSTAPVMIMTAGREGEDAITKSSTFNKIDKTGMTEVGPDSSINDRMDAIHQNKIAENYNVKNPYNNDSPSSKHQLLKVKTEQLPKPEETKQKYVFKNYANRSSMYGGFYSAMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G1C2J8</accession>
    <name>G1C2J8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_002321</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-03" db="EMBL/GenBank/DDBJ databases">
            <title>Housekeeping genes in Spodoptera exigua.</title>
            <authorList>
                <person name="He P."/>
                <person name="Niu X.-H."/>
                <person name="Zhang J."/>
                <person name="Dong S.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="18">Antenna</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="JF728817">
        <property type="protein sequence ID" value="AEJ38219.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF728818">
        <property type="protein sequence ID" value="AEJ38220.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF728819">
        <property type="protein sequence ID" value="AEJ38221.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="G1C2J8"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03706">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
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        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
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    </dbReference>
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        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16 18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="14 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="57"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AEJ38219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9421881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="465" mass="50870" checksum="A820DEC0AFA5613C" modified="2011-10-19" version="1">MATISFAKSLVNPAVKLLLKQNNCSHVRCTTGLNGLTPLSIVLRRNYAEKQVFERTKPHCNVGTIGHVDHGKTTLTAAITKVLADANLAQKKGYADIDNAPEEKARGITINVAHVEYQTESRHYGHTDCPGHADYIKNMITGTAQMDGAILVVAATDGVMPQTREHLLLAKQIGIQHVVVFINKVDAADEEMVELVEMEIRELMSEMGYDGDKVPVIKGSALCALEGKSPEIGSDAITQLLKEVDAFIPTPIRELDKPFLLPVESVHSIPGRGTVVTGRLHRGVLKKGTECEIVGHGKVMKTTVTGVEMFHKTLDEAQAGDQLGALVRSIKREQIKRGMVMAKPGTVKAHDNVEAAVYILSKEEGGRSKPFTSFIQLQMFSMTWDCATQVVIPDKEMVMPGEDASLRLRLLKPMVCEPGQRFTLRLGDLTLGTGVITKINNNLSEEDRLKLLEGKKAREKAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A385H8V5</accession>
    <name>A0A385H8V5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotein hormone alpha 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_010252</name>
        <name evidence="3" type="ORF">HW555_004521</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2018" name="Insect Mol. Biol." volume="0" first="0" last="0">
            <title>Identification and expression analysis of the Spodoptera exigua neuropeptidome under different physiological conditions.</title>
            <authorList>
                <person name="Llopis-Gimenez A."/>
                <person name="Han Y."/>
                <person name="Kim Y."/>
                <person name="Ros V.I."/>
                <person name="Herrero S."/>
            </authorList>
            <dbReference type="PubMed" id="30171635"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="MH028086">
        <property type="protein sequence ID" value="AXY04255.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000715">
        <property type="protein sequence ID" value="KAH9632327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A385H8V5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000049">
        <property type="entry name" value="Glycoprotein hormone alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052680">
        <property type="entry name" value="Glyco_Hormone_Alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129:SF2">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044075630" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AXY04255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9632327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="12928" checksum="CDC365989F39CB98" modified="2018-12-05" version="1">MLLRSLILLISLTNVLTAESWRKPGCHRIGHTRNISIPDCVEFKITTNACRGFCESWSLPSIMLGFKRHPVTSLGQCCNIMESEDVPVKVLCLDGERNLIFKSAVTCACYHCQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2R3</accession>
    <name>A0A835G2R3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001402</name>
        <name evidence="1" type="ORF">HW555_012841</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000522">
        <property type="protein sequence ID" value="KAF9406984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2R3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27768" checksum="F1D4C83487DC58B4" modified="2021-09-29" version="1">MQTLFKSRMDAYEDKLEKVSAAQSPTADLSSLQQEFMEFKEFVLRALTSFKSQIELLAQGYDRHETAMRRKVLLLHGVPEHRNEQVREVVGKVFSNEMKLAELGTSDIHVCHRLGSSSRSPRPILVRFFTTEHRQLVWDNKKLLKGTGITISEFLTQLRHRAFTAARKHFGLSNCWSVEGKIVIIAPDKSRHKIESSTQLQELVARFPSGCSSGDVPVPVDSSSPTRITAEPGARIQRRVRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2R4</accession>
    <name>A0A835G2R4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000519">
        <property type="protein sequence ID" value="KAF9407009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2R4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="47" mass="5410" checksum="5105350F93F0EDB4" modified="2021-09-29" version="1" fragment="single">HKQGGTLGNFVKWNFTKFIVDKDGVPVERHGPNVDPLDLVKSLEKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G369</accession>
    <name>A0A835G369_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000480">
        <property type="protein sequence ID" value="KAF9407354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G369"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="753" mass="87031" checksum="18AA4897065855D8" modified="2021-09-29" version="1">MTFEKTAFVYFVIIVLSISHISAWTIDLPEVRKLLFERNEKYKDYKKNDYDDFLREDQKFYSNIDGNSKHHAEDYEHVHHSYDKENYAEEYGYHTYMEKKVHAIVRDGSTYLEGLRRSLEEYNELLESCNRRNGSMQNSSSSNSTWSPAYEPPRNSSPPSGSSPPVLNFQNYENSPVPLKPNSSDSSRPGTRPGRRNMSCDEATESSEQIRRFADLALWATGRLQDIAYAKKYQKTDEQEENELILKLAWFLDRLAYLSGYEPDIKKHYNEARTTKSTPTLPPTPPTLVPSSDDLNKEMMDCLRRKSSEPATVRCRYPMEMPDIMRQIVEQGTSPSPPSSDTVVPMSGTPDNVAGPSEILITADSSLPLPQRTKRSTEYTYYFPTKPLHEVAYPVPIVKLIKHRLSNIKSVVKSIVERRLAHLAEKKEEKQHFEKHFDKRSIDDKFEVSNSINPSPDLPKPFIKSIEKKPLDATLLLHYPVSDVSVINTKSFKKRSIDNRSVTSNHVNRMSNWKSSDKYVKKGPLFRKKFENLLPSIKATRRSSKYSDSKIKSINKRFTEDPFSKLANYYIKYKVWDNSNPTNSKNYDEKKPANFDVKNHLTAPKTVQKRSLFNKKVVHMHIPKPLQIVHTYVNSLGKGHTKPRLLSHLQKLHEIKHKKHDKLHKIIKRSLKYEHMYLPRIPMDPQGDISYYVKNREGTNFNPDPVQAAQLRLGLEQVFQTGNIEVVRRFGSNYNPLNPAPFYSGIIATMTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3A4</accession>
    <name>A0A835G3A4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_014341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000989">
        <property type="protein sequence ID" value="KAF9404421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3A4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1500">
        <property type="entry name" value="Glycosyl hydrolase domain, family 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9404421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="557" mass="64322" checksum="2E16EDDAB143303C" modified="2021-09-29" version="1" fragment="single">VRYQQLKTKASILYKEITMVLVLKGKLVITIEEEVNQLSSGELFVVNAGDTADLTSDLERTCSYLTTPSEEQRPSELSSKTSQLSISAEYSEDEYQKKELIIHVGSWECLASKKVQTEILELKKQIGIKYISVHSLFTHMPLSFKIYEQAKMNSFPAFEEWDYILAFLMEAQLDVFYQLSLVAYRAMGKDIKDLTQKFFSCVQNKYGTIITSRWKDLLKLATLVDGFGFWLNIELYEQNTQKRPLKNDGLELFHYYSGKRPVYFCLWLARRMKGTILSQGEEYLLTYEAGNYQLLLFNTNYFDPHLSSEEAFLKSQAVAFELELIGIASEHYQVKQIDFNRHSGALFYMYEEFRSAKTLDLETQEYIVEQTRPKIKVFDTEIIGAFNYYKRIVTREEGTNMSIYDYQVKTTKDETVSLEDYRGKVLLIVNTATGCGFTPQYEGLEKLYKKYQEQGLEILDFPCNQFGHQAPGTNEEISDFCQMTYQTTFQTFGKIDVNGEHADPLYDFLKGEKGGLLGGAIKWNFTKFLVDRDGKVVKRFAPTVEPEKIAGDIEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3C4</accession>
    <name>A0A835G3C4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spt4/RpoE2 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000655">
        <property type="protein sequence ID" value="KAF9405983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3C4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="57" mass="6623" checksum="62D61CEE7A532227" modified="2021-09-29" version="1">MIAVMSPEDSWVCKWQRINRFCKGVYAISVSGRLPAGVIRDMKSRGYVYRPRDTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3R5</accession>
    <name>A0A835G3R5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_014449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer composed of ParC and ParE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010001043">
        <property type="protein sequence ID" value="KAF9404233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3R5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000001">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000002">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.90:FF:000005">
        <property type="entry name" value="DNA topoisomerase 4 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="entry name" value="DNA gyrase/topoisomerase IV, subunit A, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005741">
        <property type="entry name" value="TopoIV_A_Gpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01061">
        <property type="entry name" value="parC_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004044">
        <property type="entry name" value="PRK05561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF9">
        <property type="entry name" value="DNA TOPOISOMERASE 4 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="GyrA/ParC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="341"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9404233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="736" mass="83514" checksum="DB36719818A9A522" modified="2021-09-29" version="1">MVRLSQDWKLREVLIEMHGNNGSMDGDPPAAMRYTEARLSKLSGELLKDIEKETVDFVWNFDDTEKEPTVLPAKYPNLLVNGSTGISAGYATEIPTHNLAEIIDGTIYLIDHPNASLDKLMEFIPGPDFPTGGILQGKEEIKKAYETGRGKVILRSKTKIEPLKGGKQQIVVTEIPYEVNKATLVKKIDEVRLNKKVDGIAEVRDESDRTGLQIAIELKKDTNAEGILNYLFKNTELQINYNFNMVAIDNMTPQQVGLKRILDSYIAHRKKVITNRSRYELNKAQARQHIVAGLIKALSILDQVIETIRGSKDKKDAKMNLVKEYAFTEEQAEAIVTLQLYRLTNTDITQLEKEAEELNQSIAELTTILNDEKELFSVMKKELREVKKQYGNDRLTQIENEIQEIKIETEVLVAQEDVVVTVTHEGYIKRSSLRSYSASKPEEIGMKDGDFLLYSGEVNTLDHLLLITNKANVIYRPIHELPDLRWKEIGEHISQTILNLSIDESIIAVYPYKELSLTKTFVFMTKEGMVKQTKMSDFEPWRTYKSRPTSCMKLKSESDEIVNVYLTNEQKVSDVFLVSHRGFGLRYPLEEVPVVGAKAAGVKAMNLKEEDYVVNGLLVYQEGDTPIIVLTQRGGIKRMLAQELTQLGRAKRGLMVLRELKKNPHRVIFMAESSPLELLITTQTGKQFTIDSEKYPINDRTSNGSFMLDEKQDGEILEVHEMHSAELGEKSDPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4J2</accession>
    <name>A0A835G4J2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000508">
        <property type="protein sequence ID" value="KAF9407085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4J2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="158"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="36989" checksum="EB20BBECF325E554" modified="2021-09-29" version="1">MACLNTLKLEIKTLEQVFPKNHERFQIMSASVDELTCRFVGKNGKKYEIHANITETYPNTPPVWFADSEDPIVTNAVQILTNTQGRDNHVINQVGILLRELCKLHGVPEPPDLDSLSLPVHPAPQQRVPSVTSNGAESGTEEDEEMAAEEDESEGEDDLPLEMVDDAGRSNKVLFRTIVIHELVNDSLYEWNIRLRSVDPDSPLHNDLLVLKEKEGKDSILLNIMFKETYPFEPPFVRVVYPIISGGYVLVGGAICMELLTKQGWSSAYTVEAVIMQIAATLVKGKARIQFGATKVVSQSQYSLARAQQSFKCLVQIHEKNGWFTPPKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Q3</accession>
    <name>A0A835G4Q3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000493">
        <property type="protein sequence ID" value="KAF9407235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Q3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="14949" checksum="DB9FB21F4059262F" modified="2021-09-29" version="1">MNTEKLKKLQSQVRIGGKGTPRRKKKVVHVTAATDDKKLQSSLKKLSVNTIPGIEEVNMIKDDGTLGPEGLNQLKRLASSVAAPKPLDEDDEVPNLVGNFDDASKQEAKEVITNEKEKEKEKKPESETKAADKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G632</accession>
    <name>A0A835G632_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan recognition protein family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000557">
        <property type="protein sequence ID" value="KAF9406716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G632"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF77">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="100" mass="10871" checksum="0EB75864DBE0C5D4" modified="2021-09-29" version="1" fragment="single">FAVGGEGSVYEGRGWENVGAHAVSYNVKSIGICMIGDFVENLPPQDQMESLKKLIATGVELGYISPNYKLIGHRQVSATECPGQALFNEISTWEHFTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G673</accession>
    <name>A0A835G673_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000578">
        <property type="protein sequence ID" value="KAF9406536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G673"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="88524" checksum="A6BC9963BA23ACF6" modified="2021-09-29" version="1">MLDEVKIIVQGTSILALFSSLSYTDHLVFRGYVSRLALNGYDIVVMTPYPGHFKFPEAEKIIELDVSEESAPFWDEFVLLMTNTDDYYPRQKAINEFSIKLAIAQLKSKAMMSLFINPNLKYFDLVITEADVPLLYAVAEKYKAPHIAITATSGRIHQHESKGNPIHPILYPDVNTLNYGNMSRWQKIIEIYRHIQTRNEYYNNYLPLCELAAKKLFGLKRSLLEVEYDIDFLFVAGNPALIGNRPNVPAVVYVDRMHINPGLRLPRELQSLLDSSTKGVIYFSVGAIQEAEQLSPSLLQTLAEAFGEVPYTVLWRIGDTTMIKKPDNVFTKSWYPQQEVLTHPNVKAFITHGGARSLEEAVFYKVPIIGLPLVKSRKVFINEITRHGAGEILDPYNLDKETVKDTIAKVASNKKYKQAITVLNSAVFDPMVSDPDNAVWWTEYLLRHRNVRLLRSPVVGVSFFKYYLLDVACYLLLITFIDSPCGIMTAVRTCPGLYCGRTELDDGSWSDCGACPRGFRTNSTSYCVPCTDKPTLYDGLYLGFMVLLPMVLHWFFIDMVAVAKGTKNILVQHICAFVEVATGTLAALLVLPPTGTIALHVCSPKALSDWYTLLHNPQPDYKETLHCTQEAVYPLYTVVLLIYAFSLLMTITLRPWLLTWDSVNPGKKAIYCALYFYPILVLIHTVAAGLIYCSFPYIIIIISMMTSASHFSIKIEQTAPALLMSSLTNTRNLIILLGHWIIHAYGIISLTGFKELWYLSLVPAPALFYILTAQFTDPMKIHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6F9</accession>
    <name>A0A835G6F9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000413">
        <property type="protein sequence ID" value="KAF9408028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6F9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF4">
        <property type="entry name" value="DROP DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="122"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="510" mass="58635" checksum="2CECC6A0B3A61E22" modified="2021-09-29" version="1">MLQMGHRVPRYSSLLWGVCIPSSCSSFDLEEELSQRVSDLGISVKVHNNMCSVKSFKRPYSFGKTLSITFFLAILLLLSLGTILDDGKEGVTNFEKLLNAFSLKRNLRKVFDLSDSPTREKGVDAYRGINAFALLIAHKSMAMAHNPYVNKVSFSAVFGMPWAVVGRSAILYTDSFLYLSGFLNARNLLTDLERKGTINLKDRLIARWFRLFPLFVSLMLFCTYILPDLNNGPQWNLVVEEHSRVCEKNMWKSFLFIHNYFGFEDMCLTHTHQIGMDMQLYVATLPLMLVIWKYSTLGWSLLALIAMASTVLRYLAIYWYDISMFVYYGISVQKLLDAARYSYILPTHRATIYLIGVNQTRLLWTFCLVLMTATIATPYKWGLEGYQYEHFPAAMFSALSPILWGVFMSVSHWAIVNDYAGIGTAFLESRVFKFFNKIAYSVYLTQFPIFFYNVGVQRHAEFYSPLLLLHIPEVFTVTAISILTTVAIEMPFNQVYRIYFGQSQKKLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6G7</accession>
    <name>A0A835G6G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000552">
        <property type="protein sequence ID" value="KAF9406757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6G7"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001007">
        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25174">
        <property type="entry name" value="Beta-prop_THOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36681" checksum="DC8185115C58DAB1" modified="2021-09-29" version="1">MKEPKHTQTPIEDLSELRSYFASHNLVREYVAHSSKVHSVGWSCDGRKLASGSFDKSVATFTLERNRLVQDYIFKGHTGSVDQLCWHASHPDLLSTASGDKSVRIWDTRTHKCAATIATKGENINIAWSPNGSTIAVGNKEDLVSFIDTRTYKVVVEEQFNFEVNEISWNNTSDLFYLTNGLGCVHILSYPSLELQTVLKAHPGTCICIEHDPTGRYFATGSADALVSLWDVNELACLRVFSRLEWPVRTLSFSFDGRLLASASEDHIIDIGDTETGEKVAEIPVQASTFTVAWHPSRYLVAFACEDKEPPERKRDAGNLKLWGLPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6J4</accession>
    <name>A0A835G6J4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000289">
        <property type="protein sequence ID" value="KAF9409922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6J4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128349" checksum="83DCE83D4490B5B9" modified="2021-09-29" version="1">MHMRNLLGIYLSCVARRGPAGHASPRRQSTTMQLPETPPPPLAPLWDRVLRARALPPDLDVELLYVAIRDRLTHPEWEVRLHALRVLADLLPLSGNALSFPFDQVVDNLGHNSPNVRKAALDALKVFCTHCEDVECAARAILDKCSYHNIRPHSANLDTKVNVITGLILSIPSVMAILKRRHSHLDMLPIFQVLGDKLYDPVHRDVAQRSLLKLRRACGPRDYMMYLSRLDPKVQDRFRHLCETYDEDSMDVYYAPRKTAYRNNNTPLVKINHVFNNAHTGPIRVSTDSSSEDSFAPLPFYNNNFAKVIIETEIKFDSDTAITMTVLEENETESDKNTGSEDDYDSSDRNMLKYSDGDSEDTDVVVKRVRFGGESVKIRTPDSDNLLTSEDDGNVHRQQRNGNFKEIMAPPTPVIVTKMNEIKREALEREAQNKVNNNKKSGIPLPVIHNKLQKPAYVAKYNGVKIKSKSLSELYDYFRSKNEEGEGKMQEMSGLALSLAEVRSPEKSGRSSRSPVEPHKEVEVLHNLQRSPTVSPRRHQTRVELERDGFVLSLLASSPPKETDILTPRTPTPLRAHYDWEELGVVPQHVSDQLHNTENWIAAVRAADQLHSTLLEASSVRKVEPAALSLVQHMWALSEEVAAARAPAEGAVCALVRGASSDCARQLLPALISHMAREPLPAALPHALLQRLALHHIVDLIFDPSMIGVGGDKEEMQSAQLRATLCLARAAGPAAVLSAVRRRLAGTARADVFCNKLRERLSRPIENIKPSHVNRSSQLPVPVRRRARSTPPPAAPPPPRRLRPLPDSAPLPGVSQPGRDYIPFKALSPIPLSDRDSSALTSYEDGENNKKVSASKEGADERVKNSAITEVNIGGEQVQQTIPTPPRSPSIRVEDYSEKSNPSPLSGRSQLQVDPLPPQTPGSASASTGHESLESRASTVVEVSPVRKSASTRPSPTPPRSSAPSPVRSGVPTPEPASDAYDEPPQACERDVRTALAECIVPARHEDWEVIVSGLMETERLAADPSARAPAVSWRAASRSAAAHVRSLRSRVARAACTTLGALFEHRGRALDPEIEEAAGALLERCADVNRFLRADAASALVKVACGGSELLADANADTRQHARQLCLALGEDVRFKQMLKEAMPPSRYRAIEKYVDKLRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G792</accession>
    <name>A0A835G792_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_001708</name>
        <name evidence="8" type="ORF">HW555_011699</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000367">
        <property type="protein sequence ID" value="KAF9408701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000286">
        <property type="protein sequence ID" value="KAH9640356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G792"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF125">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9640356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="403" mass="48334" checksum="9A31E66B0EBE017E" modified="2021-09-29" version="1">MEEVKVEPQPQPVMKFISVTSDALTDEQREMYESVLTTWKPVMFPKRIKRYICNKCNKEFKNYQNLYLHTTRVHSSEESAVICDICDKTFKNKHYLYMHRMNKHYSELEKCYCQFCLQEFRTRRALHMHVKRIHPNTLPEIKCNECGKEFAVPYKLKYHIEACHRTDKEKYKCHLCHKLYKNSLNLNRHLHFQHTPVQRHPCVFCNMTFKSRHHMKRHVLNIHPPLESKVTCPECLKEFKNDQYLKEHMQVHSSLDSKVKCDICDKFFHSAIRLKKHKKIVHPSKPKMRCEKCNKEFAHAHYLRRHNNAVHLEMDETEYPHSCEQCGKKFKLKKYLNNHLQRHEQQHLKRISQMVKTVMGEEKDVPVKKRGRPRKARAEIEFIKCEPVSSSDSESGETESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7T4</accession>
    <name>A0A835G7T4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000242">
        <property type="protein sequence ID" value="KAF9410878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7T4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032658233" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="166" mass="17956" checksum="2845968589B45587" modified="2021-09-29" version="1">MLRVVAYVCALLALAHGQTTNVNQCTFHSGPLPIHTYIEGCVTPPCVFPQGQDAVVNIKFRAPRAVQSMTTHATAFLSIIPIIYPLGEAAQTCNYLTNSSCPLEEGEEVQYSLNMFIEPAFPVGTSLPIEFRIVDDNNNNLVCIRVPIRIAPPVSSNMLAGPAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8N5</accession>
    <name>A0A835G8N5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000216">
        <property type="protein sequence ID" value="KAF9411702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8N5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="24222" checksum="26F3036D484A89A2" modified="2021-09-29" version="1">MVIYGVYIVSKSGGLIFNYDHNIPRVEAEKTFGFPLDIKLQYENKKVIVAFGQRDGINVGHVLLSVNGTPVNGRTTEDGRDVFDIIETKENYPLSLKFGRARATTNEKIVLASMFYPLFALASQLSPVPKCSGIESLTADTFKLSCFQTLTGVKFIIVTDPSMQGAEVVLKRIYELYSDYALKNPFYSLEMPIRCELFDTSLHTLLELVEKSGTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G938</accession>
    <name>A0A835G938_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G938"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="295" mass="33586" checksum="7B7FD3B51F5B324D" modified="2021-09-29" version="1">MSDRKRGPNWHLDEKILLVDLVTEHFSIIENKRTDGITMRQKNAEWAKIAESYNCETTFTHRTADNLKAQWESLKKSTRKEAAAVRQSLITTGGGLPKPKNNDPLYDKIMGLISTTVTGLQNPFDSDNMESTNMSEEVQDNFACVEILDKTDFIPVSTQPQNTVPDAAAENIESIDKETQNITCDWGDYTPKMLQGPKSAPLRFEVREDGMREDNGRKAWSSKRRPEAPAAAALEELHKTKIRAVELQMKLAAEERADAKTIFEIDLQIKAEKLKQEKIRTRLMMARLRPKIKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G955</accession>
    <name>A0A835G955_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_010278</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000249">
        <property type="protein sequence ID" value="KAF9410733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G955"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9410733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="398" mass="44123" checksum="79980E1FD54A50A2" modified="2021-09-29" version="1">MFYRKVMHCTICLKHGTVGISGNGILLQQLARISTTQCWNSKLPLTTQTTATVKSKNIPQDNRMWKETPSHDRKNQLGNYCMMLSKFRLSSLVVMSSMAGYALAPAPFDLTTFALCAIGTGLTSAAANSINQYHEVPFDAQMSRTKNRVLVKGLLEPVHAIGFATLAGSTGLGLLYFGVNPLTAALGAANLVLYTSVYTPMKRMSIYNTWLGSVVGAIPPLMGWAGCAGALDPGAIVLSVILYSWQFPHFNALSWNLRPDYSRAGYRMMAVTDPALCRRVALRHTGVIMGACLASSYLEVTNTWFALESLPLNFYFMYLAWQFHQKSDSNSSRKLFRFSLIHLPALMLLMLVNKKNWYKSETQEQETTKVQDVKIPDSRISVLPRRPVVAAQESDLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G998</accession>
    <name>A0A835G998_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000243">
        <property type="protein sequence ID" value="KAF9410853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G998"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="2">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50720" checksum="EC63311C087596C8" modified="2021-09-29" version="1">MSSGRYCCVPGCKERGAPSTTSLQQLNLGHGPSPSSLTATMQEAALPSTSETNVHLNLGEKTTVKKAKSRVFLTNTEKYLQDKLVAASIKLSKMKNRFKKLSVNVKAAKQIASNPAAISYTFASSATKGPERAQQIKDVIRGLQESGFIVVATVCDQGPNNRQALKLLINENRGIYLRKGKNILPAECKDTADLLLFMDNIFDSVNGSRQKNRNAKPLLGPATPNSAHHQIWIEGVQIFKSMKFVSNGKKQSVPSITNWVWTLSRINKLQNEFNVSSVWLRHLNQDPLENFFGAVRSQGCRNTNPTCDQFESAFTTLLINNISSVHTRGNCEKDFCDALYSLTINENAETTSTCSSFDFSNIIEFNFTPIEIKERDPRIVGPLQYISGYFLKKIKSKIFKTCTDCCNLLMEKNEIEYIKYREYAGRRWLCTPSKKLIELISNMQDLIKQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9G6</accession>
    <name>A0A835G9G6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rac1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000202">
        <property type="protein sequence ID" value="KAF9412075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9G6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046843">
        <property type="term" value="P:dorsal appendage formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007394">
        <property type="term" value="P:dorsal closure, elongation of leading edge cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007390">
        <property type="term" value="P:germ-band shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008258">
        <property type="term" value="P:head involution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035011">
        <property type="term" value="P:melanotic encapsulation of foreign target"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006911">
        <property type="term" value="P:phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090303">
        <property type="term" value="P:positive regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903391">
        <property type="term" value="P:regulation of adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007426">
        <property type="term" value="P:tracheal outgrowth, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20253" checksum="1EEFD9FADAAD10AA" modified="2021-09-29" version="1" fragment="single">AVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWFPEVRHHCPSTPIILVGTKLDLREDKDTIEKLKDKKLAPITYTQGLGMSKEISAVKYLECSALTQKGLKTVFDEAIRAVLCPVQPIKPRRKCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9M1</accession>
    <name>A0A835G9M1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Poly(A) polymerase</fullName>
            <ecNumber evidence="12">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_010882</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000291">
        <property type="protein sequence ID" value="KAF9409884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9M1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="198"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
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            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF9409884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="430" mass="49212" checksum="D7FD8058350C5BEB" modified="2021-09-29" version="1">MKLREYLASFGVFESEQETQHRCEVLGTLHQLVRQWVRVGSLREKLPADVASSVGGKVFTFGSYRLGVSDFHMWTFYSFLTKVSLSRYTTKALTLTRCALRRHIERRSFFSTFYCLLKAKKKVGATCCSLLEYFTCMVISGNRYNVHEANISYVKDLIAVENAYVPVIKLNFDGTDIDLLFARLPLSVTDDILRNVENFRLTLRANKLWAKRRGIYSNALGYPGGVSWAMLVARTCQLYPNALPATLVNKFFLIFCQWRWPLPVLLKRVDPDRLGFLVWDPRVNLADRYHLMPVITPAYPQQNSTFNVSASTRSVMVEELKIGLATTEEIMKGNCGWECLFDTPNFFPKYKYFIVLLASPPARTTSCSGRFNSAPLNATTGQPPANCCSMWFIELQFEKSTLNLDLTYDIQTFVENVNSQARKSYMLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAS8</accession>
    <name>A0A835GAS8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_008463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000166">
        <property type="protein sequence ID" value="KAF9413241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Blast:Tyrosine-protein kinase Src-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 domain-containing protein Dlish"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
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    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
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            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
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            <end position="167"/>
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            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="339" mass="37559" checksum="E0FC7D621B528783" modified="2021-09-29" version="1">MAFLCPVRIRRGKKKKSSSGDSDKDLSRPGSGLSPGMGRITGSASIETLVRVGIEKEHGLSPDSKMVVLHDFTPCVDDELEVKRGQIVNVLYRENDWVYVIVAESRREGFIPHSYCAPCEPHDLKKKLPRSRSPTDLAHRDVSQLSVSDGVTNDGHSELGSEGEACPFSKDPSGRYVVLYTFTARDENDVDVERGEFVTVLNREDPDWYWIVRSDGQEGFIPSGFVYPAVVQASPQDTTQPVLSPATTNSNTSVLNNSKLNSSAPPQDNDGRYHGTELVMLYDYKAQAPDDLSVKRGEWVYADLTQQTVEGWLWAHAPKSRRSGFIPTAYARAPHTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBC1</accession>
    <name>A0A835GBC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9411996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="359" mass="41871" checksum="7AC770436D4B3B91" modified="2021-09-29" version="1">MAMEFYLRPSGRINLRLNNFTFYKHLKARSNAHRWSCTAYGSKWKCKAHLIITDRLEVLKANIFHSHPPSLKKEMKGPVPKLMKKEGKQDTQNNSNISIDENYPALTPFQNYLAAHSVFVNIFMTTRGKERLIFNDYTYYKQSRTKCGFRWGCTKNRWHKCKAYLHLSDDMTIVRSNMDHTHTPFSTPEHCNSLFIMISDYIHIHNITQYITLVRGSKLLLIDGFTFNKSGYIRNRGYRYTCSWYKKNCRAFAHISPDDVILKANLEHNHLPTRYAQVEAQYITLVRGTRLLLLDGFSFFKSGFIRNGGSRYTCSASNNKSCRAFAHISSDDVLIKANLEHNHLPPQYKQLSNGRYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBG9</accession>
    <name>A0A835GBG9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000251">
        <property type="protein sequence ID" value="KAF9410696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1943"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1946"/>
            <end position="1958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2171" mass="242728" checksum="8B79D9B4222052B8" modified="2021-09-29" version="1">MSASKPRSAAAGGDGPEGKKKEDKHDKEKAPDKEKDKDLKEKDKEKENKDVKEKDKEREHKDVKEKDKDKEKVLKEKDKEKDMKEKGAKSTNLEDHSKMESDQRDKDAKNKIEIQSSLNMENEGSPEQMSDVELIKTASQIAREEAEYRAMLRRQRFKRRWPEITKVKIRTKPWHPPPPPQRPPPIVVDRPSFATRPWVPPYAKKKLSRPKLPRIPPEQVNQPLPLMPSKLKKIWHNFSQVDKNKMILQGHIACNSKKYSSTHCGAQTGCIAVACRALLDEKTPAEFVRNDVDEMIATGDRYYKQCMIALKCYKGKPALQLNQLLTSFYYNDTKYTVKLLETDKGLLAKHPDNIQADEDFMALMEKRIGTQYTLILSIGGDRHFLIWGHPPDPEGNSQAQTICYIFDPHMLNELGQVDKLSGAGAFLRYAGITSFVLDFLSNYGDLDAAKQGNPKPPITLTSVEVVQKEPLIREPTYDLDLKALKVHCRSEWDSLNINALIEKKKKEGQYPLGSLSAVSLATSRATSRKKVRDFYQKMPKEPPPVLPVSPDKVPVNPTNEQIMALRGENFFLYSPRLDGHTFGRDDLIPLPKSETILHSPVEIADQNYHSQYVQLDVEKWILRGTRHMASHRYQIFKTYTAIPCCVAALGMLRRYRARAWNEDMFDETLDIGYNLFRESLVERGGPIRRLVLGELKETFRIRDREYKHKVRGIAVWGKLISNNPKVFDLCRGLEHFFKESDSGILQVPGEYEVAVWYEGGKYYLYHPWPADRYGNRVGLQDGGKGCVMYFPKVSRLCEYFMDNVSNMKRKPFSISDVAVTQLSIDMPEPVNKMKPVAPGRWIIRGSFHEADARFPEEHRGRQATPVSIAALAMTQVVDPADWTSEEVDETLVRGDILYQSTMEHLERMGISLDSPKTFEEGGSEEDEIRLPGESSPNAGTLAAADVLNRFKVSEYDCIETEVMDSTYNGTLNPEVNLGAPTLKNVLKQFFKEHTHGVFTARGGSTAIWKHDGHFYFFDPHGCDENGLPSDEPRASACLVRIKGKESDLANVLLSNLAPGSDDSFNISPVAITATKLNAEIGAPETKLESKAFEWINKGTAAIMMGPRGENAAIGKAAEKAGINKNRTSPYARSTGSSTMGKTAGFTRSTKGINPLSRKMTFRSAWDMESAFDPQADDMAGRTIGLPAAAAFAAATESVPPPHMHQDHMFNFLDAGADYYLNHLKKTGRQTIEPEDLTEKFEMGANTFSIELGEAIKLPLRLPDETPGDLLFKMWYDTTKPTTISLLVGDYHQLGLWMTAGGKVVAFDPAPTMTKGLLTSHRIRKGDELRLQRLMDEMTGEGAGEPGEEDEEAGAEGEEKIEPEIEAVPPESCPVLIVAASPGEFIDKLTRQGGLDPKQCIAPYKLYPVKVINELTSVLREKRGGTAKEKAEGDEEGGLPVFEEILVPALEDSAMGKYMNRQSRSTASVRARLAQNENYFLDQPNRDNQDAANAVMGIVVDHIEPYMFWKPELLDAVLKYGDRLYTMSIGNAESPPRLKPDEMVPEFHVTNFNVKLDIDGDVIRGDIKAGETGSVNSLKKAITSFFTTEKYGVLCSKGYCVAIWKGSDDKSFVMLEPHAVGPVGKTSPVGAAALVVFSNIEELADTFRSNVEGLMKPGDNKFSISAVKVFWEFSKLSAPVTHQGAVPDEGYEWKVLTAYVETARGRTILRGTRPPDLLKFTRDALLQSACAAIVGAAMSHIRRPHLWTRKTVDEVMAVACQLFTASLGSLGFEFRPGEDVLLPLQVLKRFVLGVNYVRYDLEEVYSGKLEQKEPSQMTVRCALERFFESHTHGILWSVPHAVCVWRVAGAPSYYMFEPHACGPTGLRVDAMDDGAACVLTFTSPKLMAFAYLQNVPVSERPKHDFQLYAMSVTVQPIKKMGGVEPPIVRAPPGVKLVPATSKVGIDGSKRRAEEKDRKHPPGSTTCMDAQRAAEKADKEQTKLKGQRNTSGWLVLTDGTQFLSAQHSMACRKFPYASRGHQALACSVMAVAMSRVEDVCRWCSSTLDQILESGDQLYQDREFFREEKAGVFVAGRGDFAVALFRTPRGYYMFDPADRDRYGRAVAPPCIGRARACFSQYPNVQCLAEKLGPNIPPSPEVVKLEDTVKFTEPPAFSIYGMDVTSLRRLNQHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBZ6</accession>
    <name>A0A835GBZ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBZ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="128"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="27797" checksum="164BD0444900C906" modified="2021-09-29" version="1">MRSRRYLEKSAIEYFKLFLSDDIVSHIVEQTNIYSTQINGTSVNIKEDDVKTFWKSSGIWESLKCMHIQIIGLKFYADIMTLKKFQLLRRYLHFNDNLKDDGDTDTTKIRENCLQVEEETRFSTDEMMKWGYKIFVRAGVSVVYDFLIYGGGDTFRFHFFTEEENSMGLGAKVVLALTKSIYSETCMQNLCFDKFFRSIELLQYLRDEYGVFALGTIRANRLREAEKKLPTDKNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC53</accession>
    <name>A0A835GC53_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC53"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41583" checksum="F1157BBACA034E34" modified="2021-09-29" version="1">MTTTYDAEEEARRLNKPVLNVPSTPLNDKGKNKGRTSMNKPTPSAVVAPQPAAPKKPRPPAPPPVTLQAAPQQQYYYQHQPDEAHGANMGYGLYGATDDSKANRNMQHNIKSHHQVSSSGQVDNTRPLEEMPYQSGEFIALKTELNDMWPAIWRVDGKTLLQKYEPFEENGKVLYRNISTYTVWNPENKKLYTQVPVKVRSQTHLETIVELVRSEMPADDCGFIEKRMLETQIVAAGAGSCRACARAAVARLLLYGQPYNPATLEPVQPDARLAYEKEFLVCATCCSRVQLYSRISHQKYLMYAECSKRVAEKRMQNPSKDTTVILNELLADEVWLSQLFRDVRHSWAEAEAWERKLRQAMSRQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCI7</accession>
    <name>A0A835GCI7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCI7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="328" mass="36323" checksum="916D9A8397499F54" modified="2021-09-29" version="1">MKIVQTLGKSPGALFDSTSKRGLEFILVFLKFAQKFWEHFSIPQKSGYVQNRVEQCPRVAVMSRHLSHIFLITVFVSLFPNPFTKALIETGLSEPTGSGEESKRCFGLYSFEGKQETHLLRTAMKFVENMDILLLLHFLSSFLFEVDKGDVKKRFFVQIGMYFEFLKLSSNIVLSGPELDTWALILCWSEIGIGGRGSAKAPNNASLTSRSELRHNLISSSSDSNDNSDLAPIGGTLGYGGAGVFKTESVLNRRTLSPAKLHLFLRPLGDRSCRGDRLGRGERLDTSGDGDRNLHSVTSSDASVSVSTGSCSLMEPNEWSRCCTLEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCI8</accession>
    <name>A0A835GCI8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="34796" checksum="2BE97D217D536474" modified="2021-09-29" version="1">MQSTASPSSSAGHGDSTSDSISPQMESYLSERTGGRIDQAVLQQQYSTQLEAKLRERDTYWEQKIEELKLSLASVQGEEAAAAQAVARTAQAEAAKAVLERDAAKRLVTELKTQLAAAERAQDRLDALNEELEQSRREWARERAELSGALSQAEARAADLADNLALLSAALPPENPHHHMEDDDKREVTPTGCADYDRVCRERAVLTRQLQEAKMALADVKTSWSGQIASLETQVARLSRQAGEEGSERRRVEIEKKELQEKLQSAAAELEKTKQNLANSEAKVVRLNGEVHSLALEVKSLRSAADHAAVSPSLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCY8</accession>
    <name>A0A835GCY8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF12">
        <property type="entry name" value="PANCREAS_DUODENUM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9412555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="665" mass="73354" checksum="69562979EF6449F3" modified="2021-09-29" version="1">MCVPGPASDKLVTEGSAGVGDQAPVADNVTGNEKLSFARKRPRNPALVGGGSLDVSSEEEGLLAPKLPTARRGRQARGASVSRPRRDAQVRFVRSNTPAASEAESDMGVTTEDPGGESCASLGSSKAELNATRREQRKAVAADEDLRRQVAALSEQQQRRTSTDAAPVVAPAPAPRPAGARTDDEVERIVRLCLLQCGSMMNARIEAISRRLPAEIIRPPLAADARRRTEEAPRPASRKAKPAEGAQKPAEGTPRAISPRLPGLRVRPGRQSWAARRPAKPLRRPQQQHAPRPNRKGGCSACAADCQSGIIVNCAFIEYVTFFLFITFRVTLFNKMNPLNQPQYSYCLPQGSVSAPLPVTAPNLNYHNWHNGQSTGWPIARPQAPTLANKKPKRVRTAFTTDQLMALENEFNQCRFLARPRRLQLADILRINERTIKIWFQNRRMKQKKDLAESQSSSAESSEDNQSPILQYHVVIPSHPAAEACAPTSSNVLPEQHQYSPNMYWETQPVIPPSNAPTQQWQPSVQGVPPQEASYPRAASVPSDLTEHHQYSPYMNGETHPTIPLDNIPEQSLQQEVLAPLLLEASHYSTEQPTQDVHNDHNNFSWPQLDLGDQLLLPLAKSDSPEVDVAFLEVEKEALPLMRYPVVEVFGVDKKDSWRNDHDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GET1</accession>
    <name>A0A835GET1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GET1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9952" checksum="CF9E31BF1AAF45AD" modified="2021-09-29" version="1" fragment="single">VNNNRFNENNTPIPSPECATNHLDYDCSNDFCPRRRHVVDWIDNKRKKLRNLGKEYKSHDGTTRLAKSLKPMCLENCRQMFIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF58</accession>
    <name>A0A835GF58_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF58"/>
    <dbReference type="OrthoDB" id="6493579at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032641282" description="Cuticular protein RR-1" evidence="4">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="13919" checksum="CA1F22D3A143439C" modified="2021-09-29" version="1">MKSIVLACMLVAVAFAAPQQGAPAEPIPIVKDDSQINGDGSYQYAFETGNGISADQKGELKKVGDVETLEVQGEFSYPSENGDPIHLTYTADENGYHPAGAHLPTAPPVPEAIQRSLAYLATAAPPQAAAPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFF4</accession>
    <name>A0A835GFF4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000138">
        <property type="protein sequence ID" value="KAF9414235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="27653" checksum="02B9E95BF424D082" modified="2021-09-29" version="1">MGLLAFGSSVVACILYFIEMMNEASPYTFRYGIHGFMDFFLAMGTLMFAFGGASTFPTIQNDMADKSKFGKSLQYGFLAVLILYLLIAIGGYAVFGERVLPNVALSMAATPLTLAANVLMAIHLLAAFIIIINPVCQEVEELYSVPRDSVGWRMAVRVSIMLALLFIGESIPRFYTILALIGATTIALLTYILPSVCYLQLVNQPVPEGQTPIESPGWMKMVCYEVIALGIVGGVAASISAFGAIFSTSMAVPCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGE6</accession>
    <name>A0A835GGE6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000078">
        <property type="protein sequence ID" value="KAF9417055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="10">
        <location>
            <begin position="43"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9417055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="285" mass="32681" checksum="BB70FDDC5947F91E" modified="2021-09-29" version="1">MKLITEKYPQIKKLFGYDPNFKWVVTGMVLVQIISLPFVTQLSWPMMLVVAYCFGGVINHSLMLAIHEIAHNLAFGHNRPLANKLFGFFANLPIGLPYQGNEVIDTDLPTLLEAKLFCTTGGKLLWLFLQPFFYSFRPLVVRPKPPTPMELINLVIQLFFDAVVIKLWGWKAIGYLLIGALMAMGVHPVAGHFVAEHYMFKKGYETYSYYGPLNWITFNVGYHNEHHDFPAVPGSKLPEVRRIAPEFYDTLPHHDSWSKVLYDFVMDPDIGPYARIKRKHHGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGJ6</accession>
    <name>A0A835GGJ6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGJ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 49-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="466" mass="51965" checksum="613E1FDC434BDCFE" modified="2021-09-29" version="1" fragment="single">CMAYTPSSRSCDTSELAFGTERGDVTLIRFLQPKLQLFHTKTPDAINYYFWMELPSPPHTSYCSIMRWRKVHSRSVKRVAYSRGGVILVSCSHDATASVRIRHVPGKMDDYVFKVIRGVTCFHIVSALHLVATGGCDGSVRLWQPCGRTPFATLAAPTSPAILDLAIIAPHELVIAFCNNCTLYIWDLYEECLLQTIKLRFPFLGVLGKKVEFGPYCIHPGPVRKELEEETEQSMLEEPIVMSRRASSVYQGSTGGLMLQLDMENEWDKKGLEDEPEFKRFNRCEILISCCDFVCTVRLGDAVGAVVPPPADTLRARRPSVWDLPDYPATSTSSTTPRLRPSLAPTPLLLSPSTAEFPVTDLDTLLENAGLQGILEKDFVLMQGLKNDLNKKLAEMEANKQVMTNAVSAGAPYLALKTYDPCLVEPVDEMLDEYRRVMKLFPTTSITGTPTGSEKSTPRRSRSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGW3</accession>
    <name>A0A835GGW3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="21755" checksum="3AC3780AC800580B" modified="2021-09-29" version="1">MREKSGHVLNNMQVFFVFVNKIKTDVKSFLHFSVFKVIILKLETQKGGQHMQDLNLRPSRFNHVRDALHHPTELMCQALNWGIFTAQSSVNPPQGEPCRTASPVKEKFFELNRLQPDLSNITVNPFSTAVFTDRRFVCKLDGSLLEDFLELEELQELQELLLLVELLRGRMESIATTLPVKRIEIMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH73</accession>
    <name>A0A835GH73_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH73"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="355" mass="40976" checksum="0AEECAA9CE32F9B9" modified="2021-09-29" version="1">MASNNKIDIGFLEEKSNWLLHPKYFPSKVGGKPAWLNLQDLPSPNELSCKKCDEPLVFLCQIYAPYEESDDAFHRTIFLFICRNGSCCQINSSDNLKVLRCQLPRKNDFYSFEPYEEIESEDFPMDKWPRLCNLCGCKGPSHCSKCKKTYYCSRKHQILDWQKGHKQICPELQTADVKPNNFIVTESGKSVLFKEWELIVDEEDEEDPKDVNINEEMEKLQKLMQEKKAGTLSNVSEDELEQYTKTMPEDKVFNKFSKRVARHPDQVLRYDRGGHPLWITGNSGNSIVNVPNCQYCNGERQFEFQIMPQLLNFIGVGIEVNSIDWGVLVVYTCKSSCSEGPAYKEEIIIKQDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHB4</accession>
    <name>A0A835GHB4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHB4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9416645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="29443" checksum="80C3EA323A28960B" modified="2021-09-29" version="1">MQTMDPRLLKHVIGAAIDMGYRAIDTAYIYGNEKAVGEAIQAKIDDGTVTREQLFIMGKLWSTFHRTDLVETACKNSLEALGITYFDLYMIHNPMSFKEGPDPIPKIASVVQFSEYDYLDAWFGMEGLVSKGLAKSIGVSNFNSVQLLRILEKGKIPPVINQGTPVEYKNSTFAVIDDPLVKVMASGLGVSPAQLLIRYQIDSGHNVVVKASCANHLWDNLQALTFELEKTQIDALNALNKNKRTFTFKGMGETHKNYPFLEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHW1</accession>
    <name>A0A835GHW1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHW1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24626" checksum="7EC3141F96AF5659" modified="2021-09-29" version="1" fragment="single">GEFVCPREEKALGRCLRDALNAYIPQLATGVPEYGVPPCEPLIVPALSIQQSSGPISVRSSYSNVTVQGPSKMRVKDVDVSTQLRRVVARLYIPDLQMTGNYRVTGKLLMLPIDGQGQFAAKYGDIDATVTIILGRQPRPNGVDALKCEDLAVSFHVGHATMKLGNLFGADDEFSHSLNQFLNDNWQKLIEELQTPMEVALRDFLKPLADHTFSTLNADDILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIB7</accession>
    <name>A0A835GIB7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_006206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIB7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000013">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032330977" description="superoxide dismutase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="13">
        <location>
            <begin position="101"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="25883" checksum="23AA9D9AB5C4786A" modified="2021-09-29" version="1">MNLRLHVFFGQFLWLLAALNGKTIQGIPGYGRNLLIKTLPAIEDYQSNIYEVFMEPYLYEFGHQVYPPGNRAEKQIEYIVPQRSPGLQAIVHLQADEESGVEGDLIFTQLVPNGPVTIEGNITGLAPGLHGVHVHQTGAVKDNCKEIGPHFLAFYGRHGGPRDNVRHVGDLGNIKAEEGPVTVKIIDHLISLAGPRSIVGRSLAISKGEDDYGRASTEDSALTGTSGPAVACGIIGYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GID7</accession>
    <name>A0A835GID7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_006155</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000013">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="18">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="236"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1055"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9416488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1283" mass="141769" checksum="2304909AD3777291" modified="2021-09-29" version="1">MSGGVRLGLTRPATPAGDLRYEAALTTMDVIKFKVNGVEHTVGSEISSDVMLLDYLRNYLQLRGTKYSCREGGCGACMITAAKTPGAPYLAINSCLQSVASCHGWDIVTIEGLGNRKDGYHPLQTTLAENHGTQCGYCTPGWVMAMHGLMESNSQMTMLDIEKSLSSNLCRCTGYRPILDSFKKFGIDCPTEDKIKSIKDMSICKQSNKCCRSYAKDNDWCMVDNDMSGEKMFTLQLKDGKTWYTPKTLTDLRKLVEENLESYMLVAGNTSKGAYPIDDYPKALIDVNHVQELKANNIDQNLVVGAGLNMTEFMDILKTSAEQDNFSYLSKLYDHVDLVAHIPLRNVATIAGNLMIKHSYNSYQSDLYLIFYTVGAQLTIVDYHGKEQIVTMNKFLELNMQGKIIVNVLLPPLSKSHKLFTYKLMPRAQSSHAIVNAGFLFKLTSENVVEEATIVYGALSEKFEKAVSTERYLIGRKLFDNDTLKGALKVLDGEMIVEDHPPEPSIEYRRYIAKALFFKALLNLAPSRASRSDSAIVDLHVTRPCSKAKQVFSTDTSLWPLNKPMPKLEGQIQCAGEAIYTDDIPSFHNEVFGAFVLSTVGIGTILKMDPSEALALPGVLAFYTAKDIPGLNSFTPIDGPGGLTSVNEEILCEGDVKYNGQPIALVVAETQNLADRAAKLVKVKYTNISTPVTDIKKAKEDSTRNTLFISADATTTGSDVHKTITGSNIVHGQYHFPMETMVCVAKPTEEGLEVHLASQWMDGAHTMISRALNIEQSKIDVYIRRVGGSYGLKITRCIQSATACSLIAYKLNRPCRFIQPLVTNMKAFGKRMPNVTDYEVAVNSSGVLQYVNLVAYTDNGCKINEPIAFYASDVYFNCYDGTKFNYKSYNTVTDTAKNTFCRAPGTLEAIANIENIMERISYELSLDPIALRLANLSSNYKEIAEVVEALKTSAEYTSRRAAVDSFNTQNRWKKRGLRWSFCRWPPAGALYTDVNLSVFHSDGSVVITHGGIEMGQGINTKAAQVAAYLLKIPVEMIEIKGNNSIVTPNSFASGGSVTTEGVIIGLKRCIEQLQARLEPIKATMTDPTWLQLITAAFAANVDLQVHGYCSALDAQTYEIYGVACCEVEVDVLTGEYEILRVDLTQDVGISVNPDIDIGQIEGAFMMGVGYWTCEKLVYNPDNGAVITDRSWDYHLPEARDIPQDFKVTLKNFYSNDFILGSKGVGEPPSCLSVVVPFALREAIVHARQESGIPTTEWFDVEGPFSTEKICMSMKTNVDDFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIR8</accession>
    <name>A0A835GIR8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIR8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="204"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="515" mass="57551" checksum="E9C396BDB8BD78DB" modified="2021-09-29" version="1">MSANKSESEYSLHQNHDIVENPRKRFCVDHAGRKSWSLLERTTDEEVLQEMGVSLLESDEESSCGPSVSGITQKSTKHRQDIENVNPNINSVMSPRSRYSPRSPKRKGSPNAGPSKAKSPRSSDKTKPLQQTEQQVLETSIIDDYLIEEETPLGQSVSAAYIPTTRATYSAGSDSSGGRQSYTPLGIEDDLMLERRHKSEPTESDSFKLLSDEMMLSVFSWLPKRTLSHCMLVCKRWYRVACDETLWVRMDLGNKTISKDALGRIMSRKPIGDWTPAAPPSASRLQYLDLSMCSISPSTLDTLLACCPNLKKLSLESLPVEDSTLSIIGRCTNLETLNLTMACGLKTEGFKALFEGCTSLLALNLGWCGISEECLQVLVEKAPQRLQRLNLGGIRTLNDDILERLVNRCPRLLELDVSDCGNLTIKSVSSFLKLHRLEHLAVNRCYMIPITELPELAALPHLQYLDIWGLLQNHSMPSFRATVPNLTVNTFMFSAIARPTVGTRRTSIWGLRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIS5</accession>
    <name>A0A835GIS5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIS5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="22696" checksum="60CB2548B09096CC" modified="2021-09-29" version="1" fragment="single">MTREKDDPEKRNLLMEQKEDKKRRQYSGSRSKTDRVSLDVVTSWKRSCESSSSEQRKRGTPYKSSSTDQRADFAQNRTRSLVSTVRRRRVGGFGLRKIVSSEYACIGCLVVLFLISVIVAYFIVCKSVPGMVSDDCKDKGVSTTLPPITDCNAADSERLKRKIEMLNGNRLKNEYPGLNEYGKDMKGYDDPMMSPNRGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ23</accession>
    <name>A0A835GJ23_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF5">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="50045" checksum="39C6CE0F3CF7C6BF" modified="2021-09-29" version="1" fragment="single">GNRTKGLQSVSQTQLVFEQSERGGLLLLRGGYQHNKKRENKNGTTVWCCVKWQTRKCRGRVVTKNNLVVSDDPHTCQPNFAANIIKKQLNQCRKLAATKSDPIPTWYPFYQLYTIHGDLGSSEETSNVVPLVYALLLNKKQATYEILFQIIKSQVPDWNPKKFQSDYEAAAMNAMQKIMPNCKIVGCYFHFKSALRKKAKELKLNKNPVHKAHVAICGALSLLPQHLISDGYLYIMEDCSNNGQILAFNDYFVNAWIESSFFGKWSFYGERFRTTNHLEGWHSKLNKGISNAKPSFIKFLDLLLKNIKEFDLKIKQFEQGIPISYRNKNVIDFDKRLAHIITQHQNCEITLGHCLEKICNLTIKTHLGRQNSLVFIKAFSKESSTAYYFRKYNDKLLHPTHTRCLNVSPSLFTPENASDYYQCTLQKADDLYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJT3</accession>
    <name>A0A835GJT3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJT3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="69" mass="8266" checksum="77116323855B8CB6" modified="2021-09-29" version="1" fragment="single">IIVTIKVSITMAGRELSGLVMKTIWLLYFFLLCFTICTAQVFSRRHPEDKYPHMKPWRDVYCSYYPQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJX8</accession>
    <name>A0A835GJX8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chitooligosaccharidolytic beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-GlcNAcase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004074</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJX8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF42">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="16">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="15">
        <location>
            <begin position="135"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9419426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="516" mass="59111" checksum="8711AB1EF60414F2" modified="2021-09-29" version="1" fragment="single">NYFCYFFRFDLQNVPAPVLSLMVDMTKLVGPNMLAECDGTVTEMVETPVVVYLTVRSANKSLTLDTNEEYMLDVQNNNKEGQISVRITAETVYGARHALETFTQLVASSKPDFSDDKTCSLLLVSGAKVRDRPAYRYRGLLIDSSRHFIPMENLKKTIDGMAANKMNVFHWHVTDSHSFPLESTRVPQFTRYGAYSAEEIYSAEEVRELIQYAQVRGVRVVIEIDSPAHAGNGWQWGPEYGLGHLAVCVNQWPWRGICVEPPCGQLNPANPQVYRVLADLYRDIADALPAPALLHVGGDEVYIQCWNQTEEIIDYMKTKNYDPTTNGFLKLWSEFHEKALAAWDEVMQAVQTPKQPVMIWSSDLTQPQWINTHLSKERYIIEVWEPVNSQLLHKLLGMGYKTVSVPKDIWYLDHGFWGITKYSNWRKMYAHVLPRDDNMLGGEVAMWTEYLDEQALDTRIWPRAAAVAERLWSDPTADVLAAEMRMQRQRARLIKRGLRADAISPAWCSQHDSRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK73</accession>
    <name>A0A835GK73_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein TEX261</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK73"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032569409" description="Protein TEX261" evidence="8">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="22796" checksum="146D626D8B43D4CC" modified="2021-09-29" version="1">MFFLYFLSLLSLAVQATFITLSIAAGLYYLAELVEEYTVMAKYIITWTVIGTASIHIGLLIFEDIPLYLNALGLVQQAFHMLLLKDFPVVRITSITFVAAVLTLILHHYLAFKFFGTVYYSFSEVLSYFTLCLWVVPFALFVSLSANDYVLPTTGEKQPLLLGDNNVLTDYLARKSKKYSLLSFFSFAKDSILPQRSKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKF0</accession>
    <name>A0A835GKF0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKF0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="528" mass="58382" checksum="D79BF862A83E80C6" modified="2021-09-29" version="1" fragment="single">LVGRGSRNTCVTSIKIMEPKVNLKQDPAYVEIQKFYDANADKINIQQLFKEDADRFNKFSLRIPTPNDGEILLDYSKNRINEQAWSLLLNLAKSRNVEKARDAMFSGEKINFTEDRAVLHIALRNRQNRPILVGGKDVTPDVNAVLAHMKEFSGQVISGQYTGKQITDVINIGIGGSDLGPLMVTEALKPYANHLKVHFVSNIDGTHLAEVLKRLNPETALFIIASKTFTTQETITNATSAKTWFLEAAKDPSAVAKHFVALSTNAEKVTAFGIDPNNMFGFWDWVGGRYSLWSAIGLSISLYIGYDNFEKLLEGASFMDQHFTTAPLEKNAPVILALLGVWYSNFYGAETHALLPYDQYLHRFAAYFQQGDMESNGKYVTRSGAQVDYSTGPIVWGEPGTNGQHAFYQLIHQGTRLIPCDFIAPAQTHNPISNGVHHKILLANFLAQTEALMKGKSADEAKAELEKSGMAADAVAKILPHKVFKGNRPTNSIVVKKVTPFTLGALIVKCTNYASSIYLCLKSVGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKT3</accession>
    <name>A0A835GKT3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKT3"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37654" checksum="E4E118C27E0FE952" modified="2021-09-29" version="1">MPKDDPETTALKKELTDLIAKVKAEQEKLADAKLAEKCGDLGDVTKIRFVTKKVLKGHINKVNSVHYSGDSRHCVTGSLDGKLIIWDTWSGNKVQVIPLRSAWVMSVAFAPSGNFVACGGMDNMCTVYDVNNRDSTGAAKMVRELAGYEGFLSSCRFLDDTHILTGSGDMKICVWDLEVGKREMEFDAHAGDVVTISLAPDMKTYVTGSVDKTCKLWDIRDEKAKQTFFGHEADVNSVCYHNSGHAFATASEDKTARLFDIRSDQQLGHYTPPGSGGFTSCGLSLSGRYLLAGSDDNDVHSWDTLKVTHTGTLRGHENRVTSISMSPNGVALASCSWDNSVRVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL76</accession>
    <name>A0A835GL76_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000053">
        <property type="protein sequence ID" value="KAF9418574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58598" checksum="EEC9B6C5D282DFB5" modified="2021-09-29" version="1">MSQNHYTGVKSVDEDVEGVAENSKISWTLFLRQLPISMLQLFVTGGVWTIYFVLGLCYGAPNVIIPQIRREANSTEAVSEDMASWLLDEDVEGVAENSKISWTLFLRQLFVVGGVWTIYFVLGLCYGAPNVIIPQIRREANSTEAVTSIHGYAALPWILILPILSRRFGRKVPFVILCINTLIGYVVFYFSTSTIILLISEIMQGMLIGSNMTLLIVVVTEYTSPRYRGIFMTVKSTIFFWGVWIANATGTFSHWKNIAIIAFICSILSLTAFFWPESPSWLALNGRFEECAESHYWLKGYDKDSENELENLIQSQKEYIARCKKKEGSSKRFKNILETISTKAFYKPLLLSMTVMSLYNFSGKFVCSMYSIELIKKITKSESTAYTGMLILEAVTIFSMQIGCVLSNCGPMILACSVYGELTPLRYRSSSLPTLAIFSEILMASVLKVSPYIFKYFELHGAFLFYGVTASVFAFLLYKYLPESKDKTLQEIECYFIESKKSEDVSEELMEEREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM3</accession>
    <name>A0A835GLM3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ku domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="12">
        <location>
            <begin position="275"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="703" mass="79229" checksum="CD02A9A2BEA4BB73" modified="2021-09-29" version="1">MSRTQGTILVLDIGRNVSVVGEKEEKSFFQSARECAARIIERKILSQGKNLIGIILVGSNTTDNNLAKQFDGAFKRIQVLDMVTPTWQMIRQLPEQPTNTKGDWFEALIVAADYYKNVLSGVKLETKQIILLTNFKKSVSLDPENIEEVLNGFTDEGYEVSVIGPDIESKQFQDNESVQLVKQFIDSTGGVTSTIENIMKYDLLFHRKKLVKGTPWNVDLSIGPNIKIPVSAYVRTRDEPAVKGWVKSVKDPVTGKSSIYESVTKTKEYINEETGQAVDAADKVAGHLYGQKIIPLGDFDNNLLYQSGVKSLTVYGFTSADNIQWQNLNGDGLSYVFGRKGDKKAQKVIRCLVECLHELNLVCIVRKVYNNNNLPKLNVLMPVIDTNNYVCLSMIGLCYKDEIKQMSFPTTNLKKYKCSEEQVDAFKDLISAMDLTDAYDDTFDDTEAFPVAECVSPSVQYVLDCIAFRALNPDQPLPKPREEIMTLFKVPPLLQEKARKPLEKLKSLFTLTKVEVKKRHNKNLMDIDQVPNPNLQTDDPVTPNIPKVHMPAKEQIVDGIKSISTINPIEDFKALQSQNKDLSELTTGMIKAIESLILNNIDGKYNKALDAMKHLRMELVKTDPTDYNNWIKKLKTDLTACGKTEVFNQIVENQVSFILKTENSLSTYEDEHSHEESQLFENDTIPNSTELTISSDVLNMFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLZ4</accession>
    <name>A0A835GLZ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Erythrocyte membrane protein band 4.1-like 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein NBL4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000116">
        <property type="entry name" value="band 4.1-like protein 4A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF4">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="9">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="772" mass="86957" checksum="B975D5F6A52044EA" modified="2021-09-29" version="1">MKESHSGWQPGCGGCGARMMDCLCPAPRTLACRVVLLDERELLHEIQDNNTGQALLDVVFRHLDLLETAYFGLRYVDQDNQTHWLDAGKRLRRQLRGSDPHTFYFGVKFYAADPCKLLEEITRYQLFLQLKQDVLRGRLPVNFDLAAELAAYVLQLLIVTICAAELGDYDPRRHGLGYVSEFRLLAHQTPELEARAAEIHRTLTGISPAQAELSYLDKVKWLDMYGVDLHPVLGEDSVEYFLGLAPSGLLLLRGKHTVANYYWPRVSKLYYKGRYFMLRVADKNNDTSTYGFESPTRSACRHLWRCCSDHHTFFRMQQTSPASADIFSLGTRLRTRLRISGEVLGVEVPAVGGSPRSTRSAPTRRGLYSASPTATRPPPAPRHRSASVDSQSSNDSRSNRKHKHRSRRQQSDAESELSRGSGRSGRRHRRHRSRHKHESGSERDDSQPDTKEYELVDSESQWKEVLRQTTVGSGVQVANVRRSQMEPETGTHRSSHRHRRHRKHRSRSGSPNDKKWLPSELKQHLEFSLVDTTGMTEEQLKEIPYTVVQTSHARQTKLRTSSKHRQAEHGSLARRDKSSSSHGKNIHDSHNQGSLRSSSSTLSTHRTGHEKHGRRVYPSYDEPVGRTGDDFLTNNGYKGNVTPISNNNNPYSPVTNSNSNSSSGELIGSARVSHEHTDSGLGADQDYAYSSERSSDSAKCGAGGSSRTAPRHASNNNILVGESGSLARRYARPTRESRDHNANVARTHSRLAHHRHDNTLDIILKPLIESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMB1</accession>
    <name>A0A835GMB1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MAGUK p55 subfamily member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="141"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="239"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="404"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64656" checksum="D208D092DF04DD81" modified="2021-09-29" version="1">MWNIVNMDSSTEHWDPALTRLLTSLKEVQSGGEDVAFLSELLQSKQLHALVQVHNKIVAKGKDDKFYPLLSNAMQVTLEVFELLHDVVSVSKEYRELLNLLQKPHFQAILCTHDAVAQKDYYPHLPDVPPELDDEEETVKIVQLVKSDEPLGGAQSAEPIVGATIKTDEETGKIVIARVMHGGAADRSGLIHAGDEVIEVNGISVENKTPADVLSILQSSEGTITFKLVPSFGKGGSRESKVRVRALFDYNSSEDPYIPCKEAGLDFKKGDVLHIVSQDDAYWQVFTVAFVFRWQARREGDRVMRAGLIPSRALQEGRIIHERQTDPQTLDGKPALCSVSNSNSDCAPKTPCSPTPSATALLPCKSTPKVKKVIYDITENDDFDREMIPTYEEVARLYPRPGMVRPIVLVGAPGVGRNELRRRLIATDPEKYVTPIPFTSRVQKSSEQNGKDYMFVSRDKMEQDIADGKFIEHGEYKGNLYGTTAESVETIINSGRVCVLSPHWQALKMLRTPRLAALHREEELSDIVRSSNRINFLYGYMFDEEIVNEDLASALSKLLKTAWRVQSEPLWVPASWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMK6</accession>
    <name>A0A835GMK6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HW555_002175</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">BAW_Kor-Di-RS1</strain>
            <tissue evidence="24">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMK6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19008">
        <property type="entry name" value="LGIC_ECD_GABAR_RDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000033">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="115"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="330"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="429"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF9421955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="571" mass="63584" checksum="6F992A33FA2D4F74" modified="2021-09-29" version="1" fragment="single">GAGGGGMFGDVNISAILDSLSVSYDKRVRPNYGGLYNWICFSNKAPLLSFAGPPVDVGVTMYVLSISSLSEVKMVFTAAKLLLRRLVSGRHVTVLWFGFHGARRARDSRLGLIAGPPVEVGVTMYVLSISSVSEVLMDFTLDFYFRQFWTDPRLAYKKRTGVETLSVGSEFIRNIWVPDTFFVNEKQSYFHIATTSNEFIRIHHSGSITRSIRLTITASCPMDLQYFPMDRQLCNIEIESYIKKPQCNGCLFYRSISLHGTVGYTMRDIRYKWNEGPNSVGVSSEVSLPQFKVLGHRQRAMEISLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVSLGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFTAVQKMAAEKKMQIDGPPGTSEPLPPPRTSTLTRPPPPSRSSEVRFKVHDPKAYSKGGTLENTINGSRGPAPAPVPAAPQPDEEAGPPPHLIHASKGINKLLGTTPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVVADDLVLLGEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNI0</accession>
    <name>A0A835GNI0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNI0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="100" mass="11643" checksum="4E4CB7A4F5A767B9" modified="2021-09-29" version="1">MRDIVPNKFIPNHDSLELITRRNPALTPKLVTLLKKKNTNKYQDGKSLRRRPRRNDSEERRGDNIPARKIATILAPKSTPMVCAIRGSCRRQQNRRRAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPS3</accession>
    <name>A0A835GPS3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dual specificity protein phosphatase 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_009589</name>
        <name evidence="6" type="ORF">HW555_001646</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000872">
        <property type="protein sequence ID" value="KAH9629199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPS3"/>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF6">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9629199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24457" checksum="4C6B3DF5D0AD9443" modified="2021-09-29" version="1">MKVLTVSDKVASVGNGNEPTVVDTQILTKEELNKGCPLGVSRVTSFLYVCGAHALPGAVRALHPGLIVSAAPELPPPPEDYVPRKFVPLLDTPNSDMHPYMESVADLINEVICNGDVVLVHCVAGISRSVTLCLAYLVKWQKMTLRDAYYHMKQRRPQIRPNTGFFKQLIKFEERLFGEPSVKMVYCEAIDKEIPDVYEADYIGMTWFRQRYGPIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPT3</accession>
    <name>A0A835GPT3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPT3"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28728" checksum="40F7EB87F1DB021D" modified="2021-09-29" version="1">MEVTPDVSEQDIDDLRVEPLFFSVTWHAKTHQCKDLNIAPIKTACLLKSKQKNVLLHLSCDMMKATYLTELLAKLQENGICNLFLVSGEGFHPTNSDFVNTTEMIKFIRAKTGQYFCIGIAGFPGCSDEKLRLIKEKVDAGANFILTQAFFDVDAFKNLKDRCEKMGVHVPLIPGVFSFETPKQLDGFINMCKVKVSEDLLNAVSDNEKMNRPCTDIIKQLIKQLNTTCNITHYHFFTINKLNDVQKLIEGINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPZ8</accession>
    <name>A0A835GPZ8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032494933" evidence="1">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="18468" checksum="B1F8FD8C7BB766FE" modified="2021-09-29" version="1">MGLAWFVLLMFALDMATTDGPPARARLPPAVSACNTGVTYNKVLLKHVTLLSKYVFTGKVFGVKSGYNGTRIYKVNIRRVLKGDLNDIGVLVKFGTAKSLRFSDATIFVESSSTSCPPLRVRTYGIFLTEKRREGGALWLSLVIEPLVLTLRSIGIIEAVVKVGHFMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ94</accession>
    <name>A0A835GQ94_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ94"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="18753" checksum="58CB4526545C2E22" modified="2021-09-29" version="1">MSELEKVDARISEMSDAESTQQHEHAVQVELPVAGSELEKIDASMSDSEAPQPQLEEATQKVFDLETADANEVMDEIIRVTQVNYEYMKQRMANPSPYGPNGGSMTEEILKKYEEKDAILDLYFDRLKTLLQEATPGFTELQIQQRQLAAALEWSSYLEFLIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRR3</accession>
    <name>A0A835GRR3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi to ER traffic protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_004137</name>
        <name evidence="6" type="ORF">HW555_000736</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRR3"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9633423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36482" checksum="5EA34905D793E30A" modified="2021-09-29" version="1">MMAARGDRGVSRVLDKLEASVNSGHYYEAHQMYRTLYFRYLSQKKYEDLLNLLNKGSTLLLQRDQQESGADLAILLIDVLNKSETKPCHEWIEKLAKLFELMSASMPERESFLTNAVKWSMDNNKKGHPLLHQRIAEVYWKEKKYAAAHRHFLHSCDGAAYASMLVELHTTKGLKSEIDLFIAQPVLQILCLRNIQMATDTFNKYTGLHPTINNNKGPPYIFPLLNFLWFLLRAIEQKHSNQFKILRNWYAISIKRDPNYSVYLDNIGRIWFGIEIPPDNKHGGSLFGGLLKSIIGEADSSDDDGDYVSRNTAAPELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS36</accession>
    <name>A0A835GS36_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Spondin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS36"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000026">
        <property type="entry name" value="Spondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF15">
        <property type="entry name" value="SPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spondin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="375" mass="41938" checksum="352303C6534FFF0A" modified="2021-09-29" version="1">MFLGQSHSSNYSLYHIGSVSSDSVRAFAQYGKIDDLVKQGDDDQQVYDQFSAPAVGSGTGATENMVFVDGRHNLVSLICRMIPSPDWFIGVDGVNLCVDSSWVDQITLDLEPLDAGAASGLTFTAPRWETNPPDPVTRHKPRLPDHPAAGFYYPLLRELPAIAKVEFTKVRQYSTKELNNLARTELLSTLKAKNEQNSEQLPTDQANDDNSDEEIEEEEEHPALTTRTNMDALKDLEEEPVGTPRPNVPENHVVVVTTAPTTTTTEKEFEGELKSMDDVVLAVAHGRKLGLHKHLPRHFRSRLHHAVNKIQPNDCLVSEWSPWSPCSVTCGFGEQLRYRSVVREKKDGGRDCPTLTDRKHCGNVNSCTHIDYFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSC6</accession>
    <name>A0A835GSC6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diuretic hormone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000136</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSC6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008036">
        <property type="term" value="F:diuretic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000155">
        <property type="entry name" value="diuretic hormone receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002001">
        <property type="entry name" value="GPCR_2_diuretic_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01127">
        <property type="entry name" value="DIUHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9424835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="305" mass="34919" checksum="F13D1CCA779C4DEA" modified="2021-09-29" version="1">MNESLFAVSSAQPQQIMRVDLRCLRNTIHTNLMSTYILSACSWILNLALQNWSDEAQQDQTSCTILVICMHYFYLTNFFWMLVEGLYLYMLVVETFTAENIKLKVYTTIGWGAPAVFLTIWVICRCFVNIVPSNAADGLALAGEAKMCIWMSEHQVDWIHKAPALAGLALNLFFLIRIMWVLITKLRSANTLETEQYRKATKALLVLIPLLGITNLLVLCGPNDDSWFAHAFDYTRALMLSTQGFLVALFYCFMNTEVRHAIRYHVERWKTGRTIGGGRRRGASYSKDWSPRSRTESIRSKLSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSI1</accession>
    <name>A0A835GSI1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="358"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="682"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="1741"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="2089"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="2372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2372" mass="278791" checksum="00EA5B85FFC8C71F" modified="2021-09-29" version="1" fragment="single">VLLCEYLSSKKILSTGTTLTQELVWLLANDCDFETALAVPITHRYPFLEIFMFYIEWKKERLANIHQVEESKRENLIKAMEVMTQPVLEKLASMPSPRFVKTHLPMCCLNPTIVDTAKVVYVARDPRDIAVSAYHHARLFTVFDFGGTFKEFWHLFTNNRFPMTPYLEHVKEAWNLRHHPNILFLFYEELTKDLKASINRVADFLGKQVTEEQMARLCDHLSFENFKKNKSVNYEGLRDYGLMTPRKDEVKREVGVTTLMRRCRNKLRNGSRTTLRILTCAFLQQNDHNYIVSFKMGEQNGGSNFPYEIEELKPEIRAELAKYYASEPDFVTIGPKKYVFLRPYLEDVENVYNMSLRPSDIFVVTYQRSGTTWTQELVWLLANDFDYETAAKIPITERYPFLELFMFFNKKWQQDLLERHEDKDKALALIEKIAKPVSERLRVAPSPRFIKSHLPMCLLPPKILDTAKVVYVARDPRDVAVSCYHHSKLFKVLDFPSPFKDFWNLFIRNLFTETPFFEHIKEAWELRHHPNMLFLFYEDLIKDLPAAIRRVADFLGKEVTPAQMARLCDHLSFENFKKNDSVNYEELREYGVLSSEEKFMRKGKAGGWRAYFDEEMTQQAEKWIEDNLKDTDLRFPTEFIFRYDKNTHPDASNSARVGPKGYIVNKVFKKDSANIYNMPLRPSDIFVTSYQRSGTTWTQELVWLLASDLDYEKALAVPLIERYSFLEMFMFVPDAGLESFIKTVSTNSENFNKEKMMGLVNWLGTPVSRALATTPSPRFIKSHLPMSLLPPKLLDTAKMVYIARDPRDVVVSYYHHTRLFMLTGFNGTFKEFWHLFHQMPLTPYFEHVKEAWEKRHDPNMLFLFYEDLSKNLPDAVKRVANFLGKKLDDVQTAALCDHLSIENFKKNKSVNFEEFRALGMLAKDEAFVRKVSLIVRVSCTEVSYQVSRMGEQKDLPFPYDTKELDPEEEELITVNLGKMPTSYVKLGPKGYMVLKPYMKDAANIYNMPLRPTDVFVASYQRSGTTWTQELVWLVANDLNYEKAAEIPLVQRYPFLDGFMFFEPEKKELYADIVSETADENFDREKYMAMMEFLAQPVSPLLAAAPLTQKRFIKTHLPMSLMPPTLLDTAKVIYVARDPRDVAVSCYHHARLFKLMGPLKGFKNFWEVFYRGLFTLTPYFEHVKEAWEQRHNPNMLFLFYEELSKFEDCLNTKSFQDLPAIINRVADFLGKELNEEQIDRLCDHLSIENFKKNKSVNFEEMRDMGVLAKGETFIRKGKSGGWRDYFDEEMTQQAERWIEENLKDTDLRLPFPFEFKELDPEEEKLIEDNLGPFPTSLIKVGPKGYIAYRPYKRDAANIYNMPLRPTDVFVASYQRSGTTWTQELVWLIVNNFNYEKAAEIPLTHRYPFLDQFMFFEPNEKEKYINVMSKTGENFDEEKYSQVLDILNRPASSTLAEVPLSETRFIKTHLPMSLLPPTLLDTAKVVYVARDPRDVAVSCYYHARLFKMLKPDKSFKDFWNLFHRDLYTLTPFFEHVKEAWEKRNEPNMLFLFYEELSKDLPTSINRVADFFGKKLNEEQMNRLCNHLSIDNFKNNKSVNYEDLREVGVLAKGETFIRKGKSGGWRDHFDEEMTKQAEKWIEDNLKDTDLRFPIKIISTLKAYINLTDRISYEKNIINSIMEEQKDLPFPYEFRELDPEEDKLVKANLGSFPTNFVKVGPKGYMVYRPYVKDAANIYNLPLRANDVFVATYQRSGTTMTQELVWLIENDLNYEAAKVLLAQRFAYLDGFMIYDPEKKEQYESILPNPEKLDIEKYLELLEYYSREGSLLLASIPPTERRFIKTHLPLSLMPPSMLDTVKMVYIARDPRDVAVSSYHHARLLYLINKQSNFKDFWEMFHRGLYTLTPYFEHVKEAWEKRHHPNMLFLFYEDYLKDLRGCITRIADFFGKKLSEEQIQGLCEHLNFEKFKTNGAVNMEDFREIGILADGEYFIRKGQAGGWRDYFDEEMTKQADEWIKDNLKNSDLRNFDTSVKMGSENFPFEIEDLEAGLAKKLMECFTGEMTGYVRVGPKKYFFPQKYKQEAAKIYNMPIKPDDVFVTSYPRSGTTWTQELVWMVANDLDYEKSYATPLTARYPFLEFSICVHPENKKKFIEENSHSQKNLELLEAVTQPGTDQLAKTPSPRFIKSHMPLSLLPPSLLDKAKMVYVARDPRDVAVSFYHLNKVMRTQGYTGDFKTYWNYFIQDLHHWAPYFDHLKEAWEKRDHPNMLFLFYEELSKDLPASVRRVAKFFGKEYSDEQIERLCDHLSIDSFKNNKSVNYDVMKILGIMIPSDQAFIRKGKAGGWRDYFDEEMTQQAEKWIEDNLKDTDLRFPHLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSZ0</accession>
    <name>A0A835GSZ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0455">Luminescence</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="13">
        <location>
            <begin position="59"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="14">
        <location>
            <begin position="485"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="13">
        <location>
            <begin position="616"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9424231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123669" checksum="CCDB1209C0FA57CD" modified="2021-09-29" version="1">MVARNLFTVNRTLTTVKQSSKYASVVIRNHSVWTQERVIKSPFKDIQIPNCTLYEYIWQNLDKWPERTASVCAVTGRGYTYEQAFKLSNRFAANLRTKFKIQDGDAVAVMLPNVPDYPLVSLGILEAGGVITSINPIYTAHEVQRQLKLSAAKMIVTLPEIVPTIKEALKLAQLDIPIVVVKTNDSPVPEGTALFNELSEDIHANKSILKQVRRTADDVCFLPYSSGTTGLPKGVELTHRNIIANCEQINEPIIAMHKETTATHQDVVMGALPFFHIYAATVLMFHKMSVGAKLVALAKFHPDAFLSCIEKQKTNVLMVAPPLILLMASHPAATAKTLESIDVVCNGAAPLAGSDVERLMRRMQRDIDFRQGYGLTETSPTLTVTPKGLVRYEATGPPVANTEMRIVDSDLNNLGPNETGEILVRGPQVMRGYKDNPEANKETLLEGGWFRTGDLGVADEDGILVIADRLKELIKVKGFQVPPAELESVLREHPSVNDAAVIGVPHQTKGESPKAFVVLKNGHKCTPQQLSEFVNEKVAAYKHVDDITFIESVPKSAAGKILRRVLRDQKVRPQFNRLCLSACFREKSVWTSDKVVISASKDVDVPSLTVDQYLFRNLDKWATKTAVICGHTNRQYTYEEVYKKSRILAANLRRKFKIKDGDTVAVLLPNAPEYPIITFGILAAGDEIQRQILLSSTTLIITNEDLVPTVKEALKLAEKDFPIISLNDKSTPEGTVSFKELVEDNNVDTSILKEVNRRDDDVAFLPYSSGTTGLPKGVQLTNRNIVANCEQQNTDFRQYEYTTESHQDSTLVVLPMFHSYGLSICMLHKMSVGLKLVTLPKFQPDMFLNTLLAHRLELMYLAPPMVMFLGAYPQVTAKHLEHVTAVTSGAAPLPSADIQRLFEKAQREIQFCQGYGLTETSPLVSLTPFGEKVYEDVGYSLPNMHCRIVDGEMNNLGPGEVGELLLKGPNVMKGYLKNPKANSEVFVDGDWLRTGDLAKINENGLITIADRLKELIKVKGYQVPPAELENVLKEHPAVLDAAVVGVPDQATGERPRGFIVLKPEAKASDKDIIEFVSKRVAPYKKINEITFLKEIPKNPSGKILRKTLKEEYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTL2</accession>
    <name>A0A835GTL2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTL2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="63" mass="7371" checksum="2E60A73FB4ADFECF" modified="2021-09-29" version="1">MNGRLPRRKLVGGQRMHQSRSDQRMTLNVTAALRSRRCIDRNPSVRSFRAFLTRAQTKTLKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GV75</accession>
    <name>A0A835GV75_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GV75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="70"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="206" mass="23215" checksum="3F5518D58BDE8A86" modified="2021-09-29" version="1" fragment="single">DWLLPDNTVAGTLKGLRRILANGSLELSPFPAEHYRRDVHATTYRCRLRLSSGFAILSKNIHVHAALNIPWEIHVPDEYVMAGNAAVLRCVVPPHCADRVSSTDWFTDDQNNVPHHLGSKYQRLDDGSLYISGVSPRDRHNAFRCRVRDRITGTLYTSPYFGHVIVTEPKGGVRPRLAIEPRTRRIQAGHDVRLPCAAHAWPVPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVM7</accession>
    <name>A0A835GVM7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_000840</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVM7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF113">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="132"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="284"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="525"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9424131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="63951" checksum="017D85BC21454C3F" modified="2021-09-29" version="1">MVIELIISDIESRVTIIQRLARLCAGGHERVSRDRDIIARDASGGCPLRDGGADGPLPVSRAHDAASAMHADPESPTCREESQLLPDDWLKVKPVPANGNLSPGIYYPTTGSKRSRSHRHGATRRARRRAILKNGECNILKSKISQRRLRFLQDMFTTLVDAQWRWTLLVFTLSFILSWLGFALIWWLISFTHGDLEPDHLPPMQEASNWKPCVFNIYDFTSCFLFSIETQHTIGYGSRTTTEECPEAIFIMCLQSIVGVMIQAFMVGIVFAKMTRPKHRTQTLLFSKYAVVCQRDGELCLMFRVGDLRKSHIIGASVRAQLIRSRTTKEGEVLSHYQTELELNADGCDSNLFFIWPITMVHKINADSPFYGVSAADVLQERFEIVVILEGTIESTGQTTQARSSYTTSEIMWGHRFVPLVTYNRERQGYEVDYSKFEETMQVDTPLCSAKELDEFYGSQGDRRSIDREPHEPKAEHNDGDFTVTFSSIPGDVTLRESINSAMLPPFVNIADRLVADAIRRASLTRRPSSVKYPPNYFSSPTEESSSSSEEETKRRRVKKKNSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVU3</accession>
    <name>A0A835GVU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="22305" checksum="C81B9EF0BF434AA7" modified="2021-09-29" version="1" fragment="single">YCIVTILFSARSVRDRWVNIRSTFNHNHRRVERSKLKAKTASDIYVPCWPLWKPLQFLKEVCKKEDSNYEFYESASSDMKQLTNNVNVKEEQQSEFENDLFLNIRQRSQRTDRPRHKSRILHKSNRKTKCKQVIDDLLVAMKPLASDPLLEQNYWFFGKHVAEQLNCMRRLDAESAANEIVNLLNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWS9</accession>
    <name>A0A835KWS9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000688">
        <property type="protein sequence ID" value="KAF9405746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="250" mass="27984" checksum="FDB5AC0A51393BEC" modified="2021-09-29" version="1">MAEISEKYNTKCPGVKRLMREAMELAEATEEYCARPLEDNLFEWHFTVQGPKGTDFEGGIYHGRILLPKEYPMHPPHIILLTPNGRFEVNKKICLSISGHHPETWQPSWSIRTALLALIAFMPTPAEGTIGSLDYSPAERKVLAKKSVTWVCPQCGEISALLSSTAAKPITEEEKSVLNQIAFKAEEEQTAKPPEEPVIEPEPQVLESSEPTNSFLDQLTEILVALLVGAIGIFIYRRWNAHYPASETEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXA2</accession>
    <name>A0A835KXA2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000579">
        <property type="protein sequence ID" value="KAF9406530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXA2"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32465" checksum="73DD020888DDE8AF" modified="2021-09-29" version="1">MAKVLTALTRSIGRPYYVTISLRCLKTSSPKMDKALENLKTNPYYEKYAARIADLQKTSPEEFMQRVELQQQSKEEEKKKKFASVDTRQFSSVLNPKQALEEVSDANEKKLSDIFKIELVKDKDAKEIQQIWEEYHKSKEVISATIPKDTYCSLQQQMQQCPTFLFPLPRSQGYEFIMCQSHGHTVHFTPLLAYQVHKENAPECLTIVHYTELADKGLILMRGEFDKNVLDGQEAQCLANQFQMYYSGKDSTKLQLLNTFTKNPDTFKHMDLIAQLENIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1U5</accession>
    <name>A0A835L1U5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000848">
        <property type="protein sequence ID" value="KAF9404949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1U5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="443" mass="47401" checksum="C5AC74365A838710" modified="2021-09-29" version="1">MIHVYFMKRCCRVHEQGARWGRPRAVFQSAVYGSPRRVHRGDRGGKDRGLLLNPRSMGIVARFLSHGAGWRRAVYPAPEAPAASGGPNTLPKRAAASPWGSDVCNTHRKKVMIMPNNDDVLSCGPVDARRSQVPGPASDKLVTEGSAGVGDQAPVADNVTGNEKLSSARKRPRNPALVGGGSLDVSSEEEGLLAPKLPTARRGRQARGASVSRPRRDAQGRFVRSNTPAASEAESDMGVTTEDPGGESCASLGSSKAELNATRREQRKAVAADEVSEMARRARERRAALAAEGEPSAVALSQLALDGVDLVLKVATKSGSLKGTFTRGLKEAAADIKEAVGTLLNRTASDEVAKLQEENGRLRNDLEDLRRQVAALSEQQQRRTSTDAAPVVAPAPAPRPAGARTDDEVERIVRLCLLQCGSMMNARIEAISRRLLRKSSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1X1</accession>
    <name>A0A835L1X1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_011145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000313">
        <property type="protein sequence ID" value="KAF9409506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1X1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000005">
        <property type="entry name" value="Inhibin beta A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF298">
        <property type="entry name" value="DAWDLE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032735638" description="TGF-beta family profile domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="10">
        <location>
            <begin position="185"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9409506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="35156" checksum="DBD434660B5481E3" modified="2021-09-29" version="1">MQLYLLLTLLHCICDFFVSVINCTDFSETVISQLPDTVISVDHNMDQRLDFGECLTSGRYPFKCLQFELPPDVEPEDVNVVELWFYKERDPLDEYNQTFVISEAAHWDSQQQFKKTKPIAIKETNIGEGWVRVELAWAVRVWLEGRERLHTLHVACRTCQLRRAPLSFHEKHRPFLVLYTKYAGKRRRGRALECGATTSECCREPLYVSFKELGWDDWIIKPDGYHAYFCKGSCSPISALSNTDSYHHNVIRRFYTVTERKAEFKPCCAPTTFSSLQLLYMDSTNTVTQKTLPNMVVESCGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L235</accession>
    <name>A0A835L235_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L235"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="110"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="463" mass="52103" checksum="01784885ADC81BC3" modified="2021-09-29" version="1">MEDELEDRVLYQTYLSFMKILSRFTSSVPLDTPVSYLWKMVRLYLLRSEVVVFTLAIILFFMYLQSIELWSRTMLSRLSQAMSPISAVQRMKILEGSDADKQSWEQKGTLSAAYAIKGRRMHMEDRFIINENINNTGISLFAIFDGHGGEFAANYAKDHLIQNLYNKIVELHAFKDGKILSPPMVEVTEEPKQKEENSITIDRKSSFKKSVSTADDTSKKEITDPELLAQLSKARPITREVRPATKPVKNIVKPLTSYMDKGKINYGKLLTDEVLAADRLLVEAAKRSMNVAGTTALLAVMEGNHLIVANVGDSRGVMCDSRGNAIPVSFDHKPQQVREQKRIEAAGGYIAFNGVWRVAGILATSRAMGDYPLKDKKFVIADPDILTFNLDDHKPMFLVLASDGLWDTFSNEEAVKFIKERLDEPDYGAKSLTLQAYYRGSVDNITVLVINFLTNKVFAAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2P4</accession>
    <name>A0A835L2P4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000197">
        <property type="protein sequence ID" value="KAF9412212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2P4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="269" mass="30057" checksum="487CE596E7C4B84B" modified="2021-09-29" version="1">MSSQSSTTASTSRKPTTDATAKVTKSLRQIAARPSEPPQASKAASEPDATDSEVATHRPTITIPETPVTKTESEDRSRISETIIDWEQCGISPPRQIISDEESSLASSAGQIDRPERKSMLYRTPRRGTGVEMDLATREANNLLQKGKEALEAAGNMKRECKTATYECLQGLYETVLSLADSRARHKYNLERERSRHAQELVRVERAHNRDVMALKAELSLMRTDLSDTKREAKGIREWLGHETLDAFKGIKEVKEEVKATKLRFKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2Q0</accession>
    <name>A0A835L2Q0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001969</name>
        <name evidence="2" type="ORF">HW555_007419</name>
        <name evidence="1" type="ORF">HW555_009939</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2Q0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="138" mass="14707" checksum="15F0530D13C5BADE" modified="2021-09-29" version="1">MGLSTAKGAAGRFTIAGDVPCVFGILDVDDTIMSPTSPHAKVLTRLHKYTLPGLCKEFLHGNLGAPQTSLCSPDLHFVSYGGKPDQNRSMMVSAGLLPQPVTYLNRSSSEIEAQFCITYAKGDIGTVLARHLSNALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2T7</accession>
    <name>A0A835L2T7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_010195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000243">
        <property type="protein sequence ID" value="KAF9410857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2T7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9410857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="782" mass="87891" checksum="B2A7BDD443EB90AF" modified="2021-09-29" version="1">MSDDEVMRFEITDYDLDNEFNPNRNRRAKKEHQIYAEQIIYKIEVCGLKDSDEEDNEDNIRQRTRKPKDFSAPIGFVAGGVQQAGKKKEESKEIESSEASTSRPKFADSSDEEEQNAPDASETAGIRRQGQGMRPVNLGGNVGTWEKHTKGIGAKLLLKMGYQPGMGLGKDLQGISAPVEATVRRGRGAIGAYGPEKAAQKAKKEEELRRLKEKEEEKGPKEKNYNWKKSHKGRYFYRDAADVIQEGKPSMHTITSSELSRVPVIDMTGKEKRVLSGYHALRAAAPRFEHEPRRQCQNFAAPQLVHNLMLMVECCEQDIIQNARELQAAEDEIVVLERDLTDCNTKLEEQDKVINRMQGILQRVEMLNQPDVSLEKAHDVLAELKETYPLEYDMFGLGTIAGNIVSPLLSSLLAPWEPLQTPDEPVPTFLKWKKLLTEEAYNSLLWQHFVPHLTTAAESWNPRTPTPMLRAVEAWQNASPDWVTRACVSRVVVPRLLAAVRAWDPTHDTQPLHQWVLPWHDLAGEALASSVYPLIRSRLATALAAWHPADGSARGLLQAWQGAWGPALTAMLHQHIVPKLDHCLTHAPLELVGRENTAWMWCVEWMGLVGASTLAALAARALLPRWLAALAAWLNANPPHATVLASYTHFKKMFPEEVLKEPAVRDAFRKALDMMNRSADIDAVEPPPPPRFAMPEPKETSRIADVITTSAPTKSFSELLETRCIEKGITFVPIPGKTREGRPIYKIGHLQCYVIRNVIMFSDDNGRIFSPISLDKLLNMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L355</accession>
    <name>A0A835L355_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_014120</name>
        <name evidence="8" type="ORF">HW555_006898</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L355"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9639256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="275" mass="31301" checksum="1F29443A5A17FC2C" modified="2021-09-29" version="1">MPYANQPSVHITELTDDNVKFVVEDTELSVANSMRRVFIAETPTMAIDWVQLEANSTVLSDEFLAHRIGLIPLISDDVVDKIRYSRDCMCADFCSECSVEFTLDVKCTGDQTRHVTTADLKSSDPRVVPVTSRHRDEDQADYGETDEILIIKLRKGQELKLRAYAKKGFGKEHAKWNPTAGVSFEYDPDNMMRHTLFPKPDEWPKSEHTELDEDQYEAEFNWEAKPNKFFYNVESSGALKPENIVLMGIVVLKNKLLNLQVQLAQEAQIDALAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3R5</accession>
    <name>A0A835L3R5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Semaphorin-2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_006251</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3R5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000369">
        <property type="entry name" value="semaphorin-2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000021">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057563">
        <property type="entry name" value="Sema5A/B-like_TSP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF79">
        <property type="entry name" value="SEMAPHORIN 5C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23260">
        <property type="entry name" value="TSP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032681926" description="Semaphorin-2A" evidence="20">
        <location>
            <begin position="21"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="21">
        <location>
            <begin position="27"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9416404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1140" mass="125292" checksum="AEF21EEED4496318" modified="2021-09-29" version="1">MMWSVYKVAALILLSALSKGQLPEDDFRIINRQDLLTTEHSDVFEDSSSGSFSQLLFDVARDQVIVGSRDALYRLSLRGLGVLERADWLAPSSKIKMCQMKGQTEEDCHNYIKVLLLHGHKLFACGTHAFSPVCSWREIESIKTVTEWATGVASCPYNPHSNVTAILASNGEYYAGTPTDFASSDTAICRSQGAASHDSGMLRTTQYDLNWLNEPQFVGSFEDDQFVYFVFREVAVEFMNCGKIIYSRIARVCKNDPGGYLVMKDSWSTFLKARLKCSVPGDVPFNYDEVQSVEYLPQEKILVATFTTPTNSIVGSAVCVYSMADITAAFDGPYKVQDRPTSTWEPRSPSKQARDHFKCVPDSRINEAIEYHRYHLMYEAIQPVSGEPIFKLTSERFTHVTVDVTGAKNIEKQLVLYVATQASHVLKLAVLPKLDGACLVERWKLNGKNNSFEVLTMQFVKDTMSIYIGGKTGIYRISGARCARYTSRSGCVLAGDPHCGWDDARELCVSAAGKLGDPAFKQDTSACPAIDAPGLYISPYQGTMHPLKETATSKLKTLTAGVDGGWSSWSQWEPCMQDGTSVSMYEDDKPDMCKCRTRRCDNPRPAFGGQPCDGASISVTNCTVHGGWSSWSGWSKCSASCGIAIKSRRRTCTAPEPKFGGRVCVGLDIDDVYCNLPPCPDPNLAAVDGGWSDWGPWSTCTASGGPGCGPSGGWKERRRECNNPVPKNGGAECEGFSTERQPCDMAPCEVRKATAWSPWVQIPGNGSDGSYTEKRFKFQCRAPSPEQLKLSMVREDERYCNSRGRCSSEPISDNEVGWEPWGPWEACSVSCGGGHQRRSRRCLKHGQCHGPSEMLQACNKLACTGEWSCWSEWSECRGECEGAEGSAAGHRTRSRSCLSPGGCAGAGDEWAALERRVCVKNCADSEAGWGEWGPWGDCTGGERIRKRACMAGACLGAQLQVARCTDDDRDIDNELYAMPAYSQNVEMASFVTTGNETLSLGSIIGCVIGAFAMGCLVCLAGVIFCQRRGTRMPWNKQHRVPSSPHYITAKQNSYVTVPLKEVPRKAKRQPSFSGIGSTSGLLLSKSNNIVNANNHNTVATTPKLYPKAIANEYDSLGTLRRHSNQPNNKNNLDIEEDKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3Y7</accession>
    <name>A0A835L3Y7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3Y7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="66" mass="7068" checksum="CEAE4A702905E19D" modified="2021-09-29" version="1" fragment="single">MNSGEAGGVVSPLPAGVDPGASQYGQAEAGRISVLIARRRGRDQVRHFTRHVLADRPAHVMDQGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4A8</accession>
    <name>A0A835L4A8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4A8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="533" mass="58778" checksum="299666710DC3C175" modified="2021-09-29" version="1">MDDTEAQVQAHKLLGQKTRVPRPPDNGLTRALRSCCVIPQRYILGVMGLLGVCNAYTMRVCLNLAITQMVNRTKSGGSHYIDPDACPSDDLINNVTSVVVEKPYAIFDWDEKTQGLILSGFYYGYAATQVPGGYLAEKFGGKWTLGVGLLSTAVFTFLTPVVIRAGGATWLFILRILQGMGEGPTMPALMIMLARWVPPHERSFQGALVFGGAQIGNIFGSFMSGILLADGRDWAYVFYFFGGFGILWFLLWSMFCYSTPNSHPYISKKELTYLNNNVTTAETINNKDPVPWKAILRSAPVWALVWAAVGHDWGYYTMVTDLPKYSHDVLKFNIATTGTLTALPYIAMWVSSFLFGLVCDVCIKKGWHTIKTGRIIHTTIAATGPAICIILASYAGCDRTAAMVYFVLSMALMGGFYSGMKVNALDLAPNYAGTLTSLVNTTSTFAGIITPYLIGLLTPDSTLAQWRVAFWVCFAVLVGTNVIYCIWADGKQQWWDDVRQFGYPEGWKHGPLTRDTVEQPESVRLSDHKASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4I7</accession>
    <name>A0A835L4I7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4I7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="567" mass="64871" checksum="3216A609E042A4F1" modified="2021-09-29" version="1">MLKENLQKALHEISKGMSKKLAAKTFSVPRSTVQFRLKNPDHRSKPGPPTILTDEEEQLFVDWIKISSKKGFPKRKEDLIKSVSDFINKSGRASSFRNGDKWFKLFLARHPTVTFRTPEAVTAASSTVSASDVRGWFEQIRIYMTENSYYDILSDPSRVFNGDETNFVLCPKTDTIEKSLNPSTIINGFRATGLCPFNEDAVDYSKCLGTSNKNNITIAQPKHVTDNRVLTKDDFTKLLGESTIHKIDKRELRPEESSECLLKIWNFFTTFQNDLHNSSKLDTERQNDNIGNFDIENMEIIINNSPNKNVAEQSFDFVSQDVVVEEIVQCSELNYFIEDISTLQERIPETHASILQPSLTYVPNNKQPSTQQTFVQQISIYQASVSSQQQSSIYSTPQKPSIRVTGDVKISADQNNFMQLKAPLVKEDNTIVKLQDILVLPKTPQRKGIKNTKKTPFVLTSAEWKAQENEKLKIKEEKAEGVKKRKEEREQKKLEKEKKMVKKNKKQTKAKDNVSKILFSEDFYKLDNDKLEALLKNYNKENQKASTSKNYSAAEIEKMLTETDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4X4</accession>
    <name>A0A835L4X4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="38722" checksum="6A94129ABB12D191" modified="2021-09-29" version="1">MKTKPMLTFSKLDPETGDLLDRMFDKKDCMVEINPGRVILPADYMTIGQDILDMEVRDSDVWMCSYPRTGSTWAQEMVWLIGHDLDYEGAKSLQQIRCPLVELSCIMVAGHSTWHKESVQGTSVDLVKHRLPFPRYIRSHLPWDLLPMDIENEDGSAKPKVIYTSRNPKDMVVSYYHYCTLVHGLKGTFEEFCDLFMRDRAPFGPVWNHILGFWNRRHDPNVLFIKFEEMKHDLPSVVRRTAHFLNKELTDTQVDKLCDHLSFQNMKTNRAVNLEAILEKSFGVSYLESTDLRFIRKGEIGDWKNYMSDDLSRRFDEWAEQHLKGTELSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L583</accession>
    <name>A0A835L583_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L583"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="29766" checksum="0AED26C75E536C3E" modified="2021-09-29" version="1">MGHLLWGLSKLVNDPSTALLDELHQRVFRKKELKRSASLEEATISSSESVELKSIQLSDAANSTTNSFFTVKNNNPETATISVQTGTGYFTNHEVCIQVKRSLLGKHNKSTSVQSALQSDRCTGASVIITKRNAKTKPMKLKVCQDHRDIVTILRQWPLWDYSKYRHNSIFQSLKSSLTGILKSFNMEKIENLPAYYAPDAEMLKLYKSASLDRLVDIEKPHRRKSNTEHCVKPRILYENCVTLKCRGINYVQNKYNTRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5D6</accession>
    <name>A0A835L5D6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000276">
        <property type="protein sequence ID" value="KAF9410129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5D6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37603" checksum="55D79EBF0AA5310B" modified="2021-09-29" version="1">MFSRVRQIRDENSETPGDFLNEVHKWSLESLGLIALDTRLNCFDASEDSESMRLIHAVQTFFLSVGELELRAPWWRIYPTKMFRQYVEALDTILSVTLSHVEKALKEIEANGGSKSLLQDLVTAAGPRVAAVAALDLFLVGIDTTSNAVASILYQLSLRPSIQERLYEEITKVLQNRPMKPGDVNQMPYLKACVKEVMRMYPVVIGNGRQLTKDTVICGYNIPKGTQVIFQHYVMGNSDDYFYNASEFKPERWMTRSPAQKHHAFASLPFGYGKRMCLGRRFAELEIHTVICKMIQAFKMEYNHEPMDYHIHPMYTPNGPIRIKLTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5G0</accession>
    <name>A0A835L5G0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_010628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000272">
        <property type="protein sequence ID" value="KAF9410234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5G0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9410234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="609" mass="69977" checksum="439711656000BACD" modified="2021-09-29" version="1">MEVGHQKPKKRPTKIEEMTKEQIRQAILKKRECNAKAQQIVESLLEPNVTETYFLQCLPDINQTHFEDIFEERSIIHLCGYPICPKTLSKKDIPKQKYRISLKTNKVYDITARKNFCSNTCYNAAMFVKKQMLTSPLWFREYEVIPKFHLLKLDAVGSMGEEVDVTLIERVKISENKSFTSINDFTNASLNEMGPSMNKQTNEETNTNKQLEGVDSNYQADVIKAIASINEGIENIDLNGNDNKNTSDTQSVSDSSQEKKETEADKKVSLDSTKPEEDKPSNKVVKPKTNPLNIVGEIIEKPERKIDPILTTPVNITNIEKENKPSKKVVQKKQPLVTALTIEVEKCLGEWFTLDTLLLLFGEEKVREMVADKGDCIREYLNNYAKGIFYNSNVYDQYQALCKKLNMLELEDRKFDNQTLKRETKPLPDYTMLQEESKKMQLKVKAFFSGELEVPEPVAEDPIQSSDLVDEENTTNLPLVDKNSQNALRRRIVCQHLNKALPDILRSLGLLSLSISSDIRLLVNTFNLKANNIMFKPIQWTLIAIIFIKLLSLRDKRLEHLLEQPTAYQHMQLLLLSYKQDGGYLDRLICWLTDIDRLLDTSDTQLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5G3</accession>
    <name>A0A835L5G3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5G3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="64" mass="6864" checksum="9F024CA4D66BCE3C" modified="2021-09-29" version="1">MHSIIVDPVPTTYIRIKTNILDANGKEMDGTSEGLSVCQYSRVPRANDNAAALTGDLETLEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5G6</accession>
    <name>A0A835L5G6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5G6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="275" mass="28155" checksum="C1FA76C6BED00D61" modified="2021-09-29" version="1">MHERGYCLQVRDASYGSSSDSDGEADGAAGDTWGVARLLYAGLGTLALGLVVYFVGTGDKGFKTPALRLVGPSLIIAGLACCLLRILFCIFAKPCCRRRTIYKENRRLSGCGEGEEMPLAGSAGGGTGGGSGGVRAGPAQCSPARRLDASSCDVSSLSSGEEDERLRRYRTASLHPPPLHQVTPHQGASSPNGLHQSGSHHSALQRSGSQHSPVAGPALTVAPQSVPASPSPGAQAPPLPSAMAGAPSRRPPPRNVSFAGGPDGELVLSPAQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L685</accession>
    <name>A0A835L685_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L685"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="56"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="707" mass="81829" checksum="63069E99875B1451" modified="2021-09-29" version="1">MRGCLHERENRRDATSGNERAKRHYIVASPARLATRPPRARDERAAGALTMFDIEKFILEVRERPALYDVQLSEYTYRNREIKAKNWYDVGSAMFTEWDDLTSKEKKEKGLELMTTWKSLRDQFRKELKLQQCSKSGQAASKRRKYIHYDALLFLKKHTEHASTSSNMFNEDSQDVFEDDDSSVNTIPSVTEPSTSNKKKTLVQMFLESNKEISNVMRESIDIQRNNVQPQYRDERGNEAFFRSLLPLMDKIKEDCLIDAKTEIMAVIKKYTPPSHTLLDSYSRTSTPTSGDDIAQMLEHFDGIIILSTETLLISLSSGTTESLLWQRDVKETRRYRYESPRNRRDTVTTRDDTRRNYRSFVEIIRRYKGGLVAILSLVEAAPKNIVSRIGDCLSDEDRVVLKEFCRRFTQAALQRWQKSNRFLDNFRRKYENWLGANIDWPSFVQILVNQEPSVDKAPRAPSVSLEPSTSTSIGTMTKRSRKSFKDLGSKQKKRRSDEHTGEDSSELVYAAAARLKEEGHGDIASVIEYMMKNPKVAAKLTETLKKPAKTVIFTPEKALGLLLSLKLSKWQYITLREAAIREGAKDIYPSYYKVQQTKLDCYPPKQSVTVTDSSARITLQALLDITRQKPMSPTMDTEHSEEELDEDEELDEEEELDEELLDDESEEEEESDRRRFAVDGFNVLFSVLAIWLKRKNDTKKKYDILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L686</accession>
    <name>A0A835L686_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L686"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9420317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="456" mass="52262" checksum="7BC7A1DE7FBEF0BB" modified="2021-09-29" version="1">MCDDVQNCCRICLDVESDHVNILENPTITLQLKACLSVTVSSNDHLPKTICSSCVSLLNQFYNFQLNARCSQDWLESSIQEKLKNKTESKMVIQPLPDSEYNSDSLLEFLNNTANIEEYLNNLGKEDIPCIVNMLDKNEHSFEISKLNNKITKVPSPKKINLAKKFKSEKDLCDSEVQMVKGIVMRELDSKTKVNQVKVESSAFICFGCKTKYDTVQKLLQHLSVCDIASRTCIHCDMLFNSKQQMQMHSITHNTSAPFTCNCGQEFPSKERLLQHHKTCLMDYAASVGCVYRCKGCGDTFKERFQLYKHAKEHIVKAEERVCDICGHTFNGTDALIKHRKDEHEKPEKVIYRCKVCNITLMDRKEMYLHVKTHTSKPEPTRHLCESCGRSFATRTSLFRHSILHASETTMCHICNKQFADGKLMEHHLKEHIEITICEKCGQGINRYKLATHTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6B2</accession>
    <name>A0A835L6B2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6B2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="13423" checksum="236E9C244D9DB9F0" modified="2021-09-29" version="1">MGRVIKTPYPNWVLVIAVLMILAGVLPIPVVLLLRRFQCLQFDVDIHQGSIRRIETTVSTKEMMSDQDVLSPENAPPAPAQLVAEAAGTRFTIGDFDGMDSSDERPNKRLPEVIARGRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6S6</accession>
    <name>A0A835L6S6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6S6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="49574" checksum="2D7518B9A81F9D40" modified="2021-09-29" version="1">MSEEEIVDIEQELSDLLIKVQPNLQDVIKRSFTNVALQQTKNGEHIKPDSLGDTSYFAKNTQVNLFRLELVKVPTFHMQALSLDLKSMSLTLRCSLGEVNVKGLYSAFNENLYNLIPVMAEGHVVISLSNMIADVRVGLVLEDDAFSFINPGIEFTHDEVLVKLSWPSPQRTGGYEFATTEQLAKHIDDLPLTAAVSLPLYALLREKLQLHLALVLRQATSVSEVMCSNPSLMEAYSGMIDSLAQNGNKVVDMILINIRRTLLQSCREVLQLPPLHATFMHKIGSLSFIGKFETDTGWVKNLATINRISDVSVTRPDPMKTSFYVTLRIKDLQIGYDEYRIRAMGVSCSGRAAAALHRHSLHLALTIGLAHWEPYAQLDHLRVQNLDCADLHVTGLGPLSGASNLVCAWLRGASTALAAPAVSAQIQHELHTALQELPLWDLLHAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L848</accession>
    <name>A0A835L848_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">39S ribosomal protein L12, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_015264</name>
        <name evidence="6" type="ORF">HW555_004668</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000730">
        <property type="protein sequence ID" value="KAH9632060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L848"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9632060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19468" checksum="8BFC3F056CB16338" modified="2021-09-29" version="1">MNGVRIIRNLPLQWRSFSRCAILRQEVAQAATPLSIPVPEGVDKPVSPKIEKIVSEITNLNLLEVSELSQVLKKRLNLPDAPVMPMGGFVAAAPAAQDEEEAAPKAVKTSFTVKLTKFDDKQKVALIKEVKGLLEGYNLVQAKKFVESVPAVVKADVSKDEAEKLKEALSKVGGVIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L956</accession>
    <name>A0A835L956_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L956"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000018">
        <property type="entry name" value="Aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016697">
        <property type="entry name" value="Aquaporin_11/12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017529">
        <property type="entry name" value="Aquaporin_11/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="293" mass="32302" checksum="1EE7115F9B851555" modified="2021-09-29" version="1">MDCSFTLEHIKLNTWEFKTHINKVTFAPLVVSTLFILLTSLLAHCARRVVQKVVKEPFVRLLFEEAIAAAELCGCCFELIVVADNFGVATYAIFLFALTIWWSLNWGDATACPYTHIEDVIEGKGDIRKALLKTWAELTGGILVFKYVQMYWALEISETHKDKAFEDCKADLQVPVIYGAVVEGIATCLCRLASRGLGDLNPRFATAIDSFIGTSLVVAAFDYSGGYFNPVLATSLKAGCEGHTMLEHAVVYWIGACAGSLLSVYVYKLPAIQKFVRGSSVANGDSIWAEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L993</accession>
    <name>A0A835L993_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heparanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L993"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145">
        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46145:SF4">
        <property type="entry name" value="HEPARANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032829064" description="Heparanase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="92318" checksum="D44508D8DFA6EC9D" modified="2021-09-29" version="1">MTTIHLFLFLLLRYLILCSSDTYSVKIGTEEHVNVVDSRFLSFTIDPKYLFSSSDKYSSKECICMAASLTPSYLRIAGPSTAHMTFHNTTISINDVDYSDKDLLRSTFDILAFDSDVPQKHRDHQTRNLAVSHRQWRKFVQWAKSTGFDLVFALNNEERTAAGMWDPNTALNILTVAEKVKVGDIFWELGYECRNQSIDEYLNDLETLRAITETFPPGRTEQWKVVGGDVTKCLQAESKSDFKDYLTLSNDMMDALLLNGNSSSHELERMTERDRLKLLRFLSRSQTPLWLTETNQKQHSDLERAADWLASLGYSAKNGFSVHFRELEEEEMYEPTLSFYMALLFKNLVGERVLNIQMDPEPAVLFAHCTSLRHKPVPGAVTLFGANMDNEPARFSLKLSKREEGGDIMQFILGNDHNGNIMVNGRPMYYEGNIKPIVKRVHPYKTLLINLPARSFGFWVLANTKIEACHNVIENKTLVEAETVEHEAHRVKRSVNDDFDDYAHIADLSYDFEDIDTYLPGNNALRSRITDMNRDLDKIQDVFKRNLGQDRFKRDISDRYGSRLHKYGFRHRTSKRYDHDVNPKKFIDDLLERARQRLNDLKELRSSMPKLNINRKSSKYPKTSYKVRSFKSLKEDSPIFGGRSRKQKTTKTLTEDSDEFLKKVNKKSKSDEDKKTGSDEGTNVSESLVRRRRSIDNDIKETSADNEIDLTGKNKAKLLKLLKKLEEEFGETSEEHIENEIDSTEGIILKTEVSDDSATIRVKDSNHGVIKTTMRSMLHMLEDFNKNLNKVWNAVNLLDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9E8</accession>
    <name>A0A835L9E8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9E8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="669"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="838" mass="91424" checksum="216ADB8066479CA0" modified="2021-09-29" version="1" fragment="single">REENVKCDILSAYTALLRATRPPPALQITIVPTDNSPQALLLQRVSGVVRGALRVIRGRSIRARGAALALLRELLAAAPGCLADHAARVIRALTPALTDKSTASSMKIETLVFVVCLVRGHPASTMRPHVGALLPAVLCCVHDPFYKVTAEALRVLQTLVKVMRPLDDIPVGGAQMVDAALQQYIPAMYEVTLVRLRATDMDQEVKERAIAACGQLLCHFGDYLQHELPVCLPIFLERLRNEITRLTTVKALTKVASSPLRIDLSPILSDAIPILGSFLRKNQRALKLSTLVLLDTLVQNYSNAISIELLSKVLLEVPALVVEADLHCAQTALTLVRGACIRLPAALTPEARHALTPNILALAKSPLLQGGALKAMLGVLSALVSADVAGCSRRDLLALLVAPVHKLTDHTASTHHIKQAFHSLAKCVAAVVVEGGSDALDVVRGFLRDIAHPASDAHHMFALLALAEIGRHLDLSSIPNLKEALLSSFTPSSEEVKSAASYALGSVAVGNLPEFLPFILGEIEAQPKRQYLLLHSLREIISCESCTPEGVEALRPFIPEIWVQLSKHCQCAEEGSRNVVAECLGKLCLLEPQDLLPHLKEFLKSPEPLTRTTAVTAVKFTISDQPQAIDPLLRGCMSELLVPLRDPELGVRRVALVAFNSAAHNKPSLIRDLLPQVLPTIYSETKVKKELIREVEMGPFKHSVDDGLDLRKAAFECMYTLLGTCLDRLDVFEFLRHVEDGLRDHYDIKMLTYLIATCTMKVKANSVKQEYEKQDELKRSALRAAAALLQIPEAEKNPHLMDFVTQIKSFPDLQPIFESILKDSSGGGGVDSNLMDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9X1</accession>
    <name>A0A835L9X1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Dynein heavy chain 10, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_000036</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000006">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="19">
        <location>
            <begin position="186"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="17">
        <location>
            <begin position="361"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="16">
        <location>
            <begin position="633"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="994"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="1461"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="20">
        <location>
            <begin position="1604"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="21">
        <location>
            <begin position="1757"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="848"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9424735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2039" mass="233380" checksum="5067D99316CB0253" modified="2021-09-29" version="1">MEYVERPVLMVGETGTSKTAIVTNFLRGLPPEKYLVQQMNFSSRTSSMDVQRNLESVVEKRTKDTFGPPVGKKMLVFIDDMNMPIVDKYGTQQPIALLKLLFERKGFYDRGKDLNWKNIKDVGFLAAMGKAGGGRNDVDPRFISMFSVYNLQFPSENTLRHIYVSILKGHFDVFPEEIQNIVEKIVQMTLDLYKVIIVDLPPTPTKFHYIFNLRDLSRIAAGMCLTHPNYFSEKRCVVRCWRNEFTRVICDRLISTQDNDLMRGHIHEHVMKYFPEEEPVVLEEIVVHEEDLKIEEEQELDEFGMIPEQKPESEMEEYVFRDPLLFGDYRNALDEEEIRYYEDLLDYEAILDEYNERVGKMSVVLFEDCLEHLTRTHRILRMDRGNALIIGVGGSGKKSICRLASFAAGCEIFEIVITRNYNENTFKDDMKRLYNALGCENKKTVFLFTAAQIIEEGFLEFINNILMIGMIPALFDDDEKDGIINTVRAASAEAGYGVGKDSVWNFFCTRCAENLHVVLSMSPSGDILRNRCRSFPGLVNNTTIDWQFPWPKQALLAVANVFLADVAKIPEEFRPIIVEHVVHVHMSVAHYSNEFLLRLRRNNYVTPKHYMDFLTNYLSLLKEKDAFIVAQCERLIGGLAKIEEANVQLEDLNAKLVVQKVIVAEQTKECETLLAEISKATTAATAKQTVASIKSAEITEQSAVISEEKAEAEEVLSAALPALEAARLALADLDKNDITEIRSFATPPEAVQTVCECVAIIRGVKDISWKGAKGMMADPNFLRNLQEMNCDLITQQQVKAVKAHMKKSKKLDTMQQISKAGYGLLKFVIAVLGYCAVYKEVKPKKDKVEALEKEYTEACNYLASLNREIDRLQRTLDGLNNKYETAMLRRQELQEETDIMMRRLVAADKLMSGLSSEQKRWTEDLGALYVEQSRLIGNCLLSASFLSYAGPFSFSFRQTMIYEDWLGDVLERGIPLTTPFTIEKNLTNEVEISGWNSEGLPPDELSVQNGILTTRASRFPLCIDPQTQALSWIKKKETKNNLKVLSFNDPQFLRQLEMAIKYGMPVLFQDVNEYIDPVVDNVLEKNIKTESGRTFVLLGSTEVDYDPNYRMYLTTKLSNPQFNPATYSKAVVINYTVTVQGLEDQLLSVVVRAERSDLEEQRESLIIETSANKSLLSGLEDSLLRELATSTGNMLDNVELVNTLENTKAKAAEVMEKLQLAAITTKDIETLRDGYRPVAKRGSILFFVLSDMAGVNAMYQYSLSSYLDVFSFSLRKAMPNVILVKRLKNIIDMLTKNVYDYGCTGIFERHKLLFSFQMNIKLEQSENRVSQMQLDFFIKGNISIEKSARQCPASWIPSQGWQDVMKLSMDFQDSFSSLPDNISRRLNDWQEWFDSDTPEANDIPGGYRDKLQPFEMLMLLRCFRVDRIYRALTDYITVTMGEEYITPPVISLDMIFEQTTPFTPVVFILSPGSDPTADLMKLADRCGFGGGKFKYLSLGQGQEGAALALLEGAISHGQWLILQNCHLLVSFLRELEKQLELMTKPHPEYRLWLTTDPTPTFPIGILQRSLKVVTEPPNGLKLNLRNTYFKMRAQALNECTHPQFKKLVYVLAFFHAVVQERRKYDKIGWNISYDFSESDFVVCMQILQCYLDRCHAVGGPIPWATLKYLFGEVMYGGRVIDDYDRRVVSTYMEEYLGDFLFDKFQPFHFYHDSFFDYVIPPDGEKEQYIEFIDTQPLANTPDVFGLHPNAEIGYFSQAVREMWRHLIELQPQTREGGGALSREDFIDIIALDVLSKLPQPFEIWRVRKQFNRLILRMRSTLSMLRKALAGEVGMDAVLDNVANCMFNGQLPEVWRELAPATCKGLGGWMDHFIARTKQYTDWATIEEPVVMWLSGLHIPESYLIAHIQIACRLYTWPLDRSTQFTKVTGWVCPDEIEERPVTGCYLRGLYLEGARWDLEEKCLRRSHPKVLVTELPIMYVIPIEAHKLKLQNTLRTPVYTTSQRRNSMGVGLVFNSDLWTAEHPSHWILQGVCLIMNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB80</accession>
    <name>A0A835LB80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_005443</name>
        <name evidence="3" type="ORF">HW555_005377</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000635">
        <property type="protein sequence ID" value="KAH9633809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="254" mass="27045" checksum="EA178B6370FC9FEC" modified="2021-09-29" version="1">MSLAGKVVLLTGASSGIGAATAVFLSKLGAQLSLTGRNVENLKKVCEECEEPSSIFSVPADLTKESDIEKIVKNTIDHYGKIDVLVNNAGIIETGTIENTSLGQYDRLMNTNVRSIYYLTMLAVPHLIKTKGNIVNISSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNCINPGVILTELQKRGGMTEEQYAAFLVRTKETHALGRPGQPDEVAATIAFLASDLASNITGVSVPVDGGRHAMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBD7</accession>
    <name>A0A835LBD7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HF086_008809</name>
        <name evidence="20" type="ORF">HW555_005185</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">Golgi stack membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000003">
        <property type="protein sequence ID" value="KAH9646001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBD7"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9417771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9646001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="193" mass="21823" checksum="2F66CC3D7F249016" modified="2021-09-29" version="1">MFILDWFTGVLGFLGLWKKSGKLLFLGLDNAGKTTLLHMLKDDRLAQHVPTLHPTSEELSIGSMRFTTFDLGGHQQARRVWRDYFPAVDAIVFLVDACDRPRLPESKAELDSLLTDETLSNCPVLILGNKIDKPGAASEDELRQFFNLYQQTTGKGKVSRSELPGRPLELFMCSVLKRQGYGEGFRWLAQYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBT1</accession>
    <name>A0A835LBT1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="638" mass="70627" checksum="B28E314C6DBA16EB" modified="2021-09-29" version="1">MVRLIYNVRSLFSVNSHRFPRIVSRRLKSSDASDNNIDVKKIRNFSIVAHVDHGKSTLADRLLEITGIIKPGAEHAQVLDQLQVERERGITVKAVTASLNYTYNNEKYLLNLIDTPGHVDFSNEVVRSITACQGVIMLVDANEGVQAQTVAVYSLAKRNNLLIIPTLNKVDLPRADPEKVKSQLQSLFKIEPESVLSISAKKGWGVKELMEAVITRIPPPSVDTKGHFRAHIIDTWHDKYRGVLCLAYIHSGKVTVGQAVKWKSDSKPQTVKFLAMLRPNEEPIDEAVAGQVVMVGCGPKGGGSVGDQLLAKELADSDSGSSVPPVKHMVYAGIFPADQSQHPQLSDAIKKLALNDSAVAVTPDSSPALGQGWRIGFLGLLHLEVFTQRLLQEYKAEAILTAPSVPYKVKVKGAKAIKQYKGTEVVVTNPLLLPDANNIEEYYEPFVIGTIITPVEYLGAVTSLCIDRRGTPLPSNAVDDRMTMLQYILPLSEVVIDFHDTLKSITSGFASFDYQDYGFHPSALVRMDILINGVLVDELSTIVHTSRLEYNARRLAEKLKEMIPRQMVQVAIQAVVGGKVFARETIKAYRKDVTAKLYGGDVTRRKKLLKQQAEGKKKMRSVANIRIPRNTFIDVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LF18</accession>
    <name>A0A835LF18_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LF18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032973389" evidence="1">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="27707" checksum="DEA8DB0D0E5737B9" modified="2021-09-29" version="1">MSSEAKSVLAMLSVLLLLFCAVVSVLSSPAISLTQCKTDDDVCTTKAVNLAYPLILEANPEIGAESIDPLFQPEIEGNLSILKFKLFNTTVTGFKTCNVENAKYNDEQQTLRIDVVCGAFTLSGTYDINGQLIVLPVQGNGDYVLTTKKYRLIIDVELKTVTGKDGKNYRAVKNFKVEADPLEPVNYDFRNLFNGQKDLADTVLKFANENWREVAHEVQNPVFVANIKKMVKNANKYLKTLPIEDYVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G104</accession>
    <name>A0A835G104_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000702">
        <property type="protein sequence ID" value="KAF9405653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G104"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="176" mass="20270" checksum="84D019E5E9E2BAC3" modified="2021-09-29" version="1">MLRFLDVVREMRPTTSNLEDKFDETSGEENQLQETGSESSNSNSKPGSRKTQSMTLFQRSLINSMEKSSQDDNDSDKQFLLSLLPQMKKMSEAQNFDFRLDVMNLVKKYRFVTTNTVQQYNILSDQCNYEQNRSPLPQTSQFEHGGYYTTDYYTDSPQSASSRVSADEDIEALMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1D7</accession>
    <name>A0A835G1D7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000904">
        <property type="protein sequence ID" value="KAF9404698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1D7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="74957" checksum="733ADF9746FA554A" modified="2021-09-29" version="1">MALLTKQVGIFEDIKTLCTNYKKDSITRKNVEYLEKRLKNLEELWGVFEKQHKILVETTEHKNIGYFNNDVYTKTKTMYESTKRHILDLMASQNKQPKQDLNFDLSGLIDEETEDGVKKLITQQERNFKALTKAMSKINIDFITENWEFEEHLATLKAKWQSIDKIHWELDDELKGSSLNEDYNEKYETIEQKYDSLKRDLNSKIWSKIHLQKSTPKIEIPEFTGKYVHWITFKDIFLETIHNNPSIPKAQKMQHLKTKLKGEAERLVQHLSISADNYDSCWEILSHRYDNRRLQFTSFMSTMQHLPTIQQPNANNLKRMHDVITECLNGLGNMGVEVSSWGPMIVYMMSQKLDPTTLNEYTKETQNNRELPDLDEFLKFLELSFLAHETAKSCLKDSGENKTPHRPMTKSWNHNYKFKSNFKKPEEQTKVGHSKIFHASFGKCPLCNNDHVLMQCDKFINMDILQRNKTVAKLKLCKNCLYSHGNNNCNSKKTCRECNSKHHTLLHTKPSDSEPTAERRDDSTNSRPSTSTQPASHHVKTEYTEILLTTVLVKVKSADGTYVTLRGLLDQGSQINLITENAAQLLRLPRKKLDAAVTGIGSTITDVEMQSKKPPAKKARDGADRMTSGNPPPTRRTLDSDTDIEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2I3</accession>
    <name>A0A835G2I3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000551">
        <property type="protein sequence ID" value="KAF9406764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2I3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="199" mass="22645" checksum="14636D2A9601D355" modified="2021-09-29" version="1">MFAAFNIMATADDRYVNYITESPGMIYDPVGTVKIISDQFRIVIPIDVSPFNEYIENVHDILNIIQNQCRQNEEIDYSLCQNMLQPLESLFKDLRRDYNSISHIVSNNPKRRSAWFSGIGVVFKHIFGTLDEDDAENYNKAIRTINTIDAIALATLTPLDTKVLECTKSEKSRITGKSEYLPDDITLDSPTHPNAYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2Y5</accession>
    <name>A0A835G2Y5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_011168</name>
        <name evidence="6" type="ORF">HW555_012706</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000499">
        <property type="protein sequence ID" value="KAF9407167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000187">
        <property type="protein sequence ID" value="KAH9642575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2Y5"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9642575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16546" checksum="A5E1B17BEBE8E0A1" modified="2021-09-29" version="1">MSAGTYYFVIVGHSDNPIFEMDFIPVTKEPKKEDNRHLNQFIAHAALDLVDEHMWKVTNTYLKSVDKFNQWFVSAFVTASQMRFIMVHDARNEDNIKNFFTDVYEAYIKLMLNPFYKEDTLITLPAFEKKVQFLGKKYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3J2</accession>
    <name>A0A835G3J2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000807">
        <property type="protein sequence ID" value="KAF9405116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3J2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="208" mass="23004" checksum="93752D5E5245F88E" modified="2021-09-29" version="1" fragment="single">NELKCGEHEEILCLHSCPPVKTCHNLYVEVSCLTPTEPCENVCVCKDGRVRNAKNVCVPIDQCEPKCAGPNEVFTTCKKSCPPDICFSLVAKFSCDANELCQNGCVCKPGFLRKSLDSPCIPICQCPEMKYSPDCKNEVYSDCKQTCPPEICFSIVAFYDCYDKQDCEKGCACKPGYLRTEMNTCCVPLCQCPELVNAPECIATKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3T6</accession>
    <name>A0A835G3T6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000426">
        <property type="protein sequence ID" value="KAF9407877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3T6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="586" mass="66182" checksum="FE46BF80031605E3" modified="2021-09-29" version="1">MSYYNCSLRRETPLGTDMVKVAVVTGSNKGIGFAIVKGLLKRFDGVVYLTSRDVARGQEAVAKLNKLGRHPQYHQLDVTDRDSVAKFRDHIQEKYGGIDILINNAAVANIEDRTYEASKTVVDINYFSILTIQELLFPLVRNNGRILNISSDCGHLSNIRNDYWIQRLSKKDLTVEDVNEFANWFLEGVKKGTFDYGDIADGGSIASYRVAKVALSAITRVQQKELEAKNISVNSMHPGLVQTDMTRGVGFYDIDQAADTPIYLVLDAPDTLKGAYIWYDKRVLDWYDYKADYYFKIKTLEKVAVVTGSNKGIGFSTVKGLLKRFDGVVFLTSRDDGRGKAAVAKLNALGLHPEYHQLDVTDRNSVAKFRDYVRDKYGGIDILINNAAICNCTDLYLSYEESKNIIDINYFSFFIIQEYLYPLVRDNGRILNISSDCGHLSNIRNEYWIKKLSSKDLTVKDINEFVNWHLEAVKNGTFNRADFADEGTIAAYRVAKVAVSALTIIQQRELDGRNISVNSMHPGLVRTDMTKGVGFLDADQAAETPLYMVLDAPASIKGAYVWYDKQVLDWYDPKADWYFKSINFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G416</accession>
    <name>A0A835G416_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000568">
        <property type="protein sequence ID" value="KAF9406634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G416"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="5">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="26460" checksum="2D77A04DBA7CD631" modified="2021-09-29" version="1">MSDIKIVAASIVNFLKRQLEGDSLSVDSRESVEVGVQCIETAFELGPEDAARGVDLLQLVRAQVRPTSLTAPPSRSEAEKLKNEARDFEGSVADCTAALGLQPDYGKAHSRLGLALTALERHREARAAYARAVQLEPENETYRQNLQVTDELLASHGERAPLDLGGLLQNPALLNMATEMLADPNMQNLISGLMSGAGGAGAGGGQAGGAGGMSALLEAGQALAQHMQAANPELVEQLRRQVRPPGPNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4H7</accession>
    <name>A0A835G4H7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000493">
        <property type="protein sequence ID" value="KAF9407236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4H7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="217"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="307" mass="34320" checksum="6B4BB68C80756FEA" modified="2021-09-29" version="1">MALATGLGFIIRAGIGKGEEFEQKRKTKKTFNLPVFPHVVPKTGTAFGQNGYKLFLTAITIIGTSTRISCARLVGPHLTIIAFDPVLYRRSKEKMYSTVEERSFATYIFVSKRRMPLPKERMAVVKMQRLTLVNEALSSEIAIKSSVSEPSQRSDHEVSPSTSHTNVCDQPGCSTSRIGCDDLQVELSTSHIEKTLHCDKAVQVNIKPNYRSKGVNALPPNKAVMADRGFKDLSCLLEAKRCTLIRPPSVSKSTPSTKNEVKLSKRIAALRIHVERILEDLSKFCVGHKACEFKIFINLEHKTWFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5V4</accession>
    <name>A0A835G5V4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000319">
        <property type="protein sequence ID" value="KAF9409447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5V4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032820179" description="Inosine/uridine-preferring nucleoside hydrolase domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="343" mass="38106" checksum="4B0C8F1E44D7BEF7" modified="2021-09-29" version="1">MVMFVWVIMARKILCFILLTVYWIASSDASPVCSRKKLVIDHDGGADDAFAITISLLNEEYFNGPELIALTTTFGNVNLTQANINSDRILRVSQRRDIPIYSGANKAFIENMGTDGFFGVDGLGDTSYQPPNSIDIEKQPAAVALIELSKKYEGELIVVAIGPVTNIALAVKLDPQFINRLSQLYIGGGHIYSEEYPKAEFNVAMDPEAYHIVVDNATTDKVTIIPFSQVKESLKIPIEWRLNVLGAIDTPIMKALNLYEQVALPKEKVWNLLDPAVAAIALYNEIVDEFRNTNNTIILEGAKRGINTNDFSSSDPNARVVYKGNVEYYKKFLLDVYSAELNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6E1</accession>
    <name>A0A835G6E1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000418">
        <property type="protein sequence ID" value="KAF9407974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="129" mass="14602" checksum="6030EB36A060C2DD" modified="2021-09-29" version="1">MNLKFEEIKTEFSSNIKVVNEIKKENEQLKTTVKDLGMRLSLMEQQARSTNVEIQCLPGHNKEDLVSTVLNISKVISGDINESKIHHVTRIAKQSPANNPPKSIVVQFSSPQIRDNFLAASINFNKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6J5</accession>
    <name>A0A835G6J5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_012117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000408">
        <property type="protein sequence ID" value="KAF9408095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6J5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF50">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032427541" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="307" mass="34544" checksum="EFB87B5E215360F2" modified="2021-09-29" version="1">MAGLLYFGLLLIIGFTQCEPVEPEIAYIDDSLRGSRIVSGWEAVNGQFPYTVSIRMVGPTGGVGACTGSILTNEWILTAAHCLARRFTFVVRLGQVDITTPGYMVEATEKYIHEGYDQEDTAVQTDDIGVLKLDRYIPYGDYIQPIRLQSSQRNEEEYTNLQLVQSGYGRTDDWWAGGIVPDILYWTYQRGISMLVCRSWYPRSQVIHDRKTVCAQFYNDTSQNPCTGDSGGALTIIDVDGKPTQIGIMSFGSSRGCNTHNPSGHVRPEYYHDWIEKQTGINFDWNVEDLETKPDGEGVNQQIRFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Q0</accession>
    <name>A0A835G6Q0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000448">
        <property type="protein sequence ID" value="KAF9407664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Q0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30386" checksum="9098B311B01E9D25" modified="2021-09-29" version="1">MIWRTSGGRRRPASARTDDEVERIVRLCLLQCGSMMNARIEAISRRLPAEIIRPPLAADARRRTEEPPRPASRKGKPAEGAKKPAEGIPPSDQPTTAGSKGETWATVVGRKKARKAAKAASAAARAPGRTAKAVAQPARRTAKGGRKGPTLHAPRSEAVTLTLQPGAAERGVTYASVIAEAKARIKLSDLGLQSVALRQAATGARLFEVAGAASGSAEKADALAAKLREVLNPEDVRVSRPMKTAEVRIAGLDDSVTSRHGLTRHWAEDLASSTGARCLRAPLRGCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G770</accession>
    <name>A0A835G770_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000329">
        <property type="protein sequence ID" value="KAF9409221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G770"/>
    <dbReference type="OrthoDB" id="6595846at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032971995" evidence="1">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="149" mass="17005" checksum="C32289129839E7C0" modified="2021-09-29" version="1">MFINKHITIHILCAVYYVVGQQDKESKFGEIVKRTVIAAAHTCMDHVNATTKDLENLRNEPPYPETSACIVKCLLEKIGVVKSNRYSKMGFMTAVTPLVFTNKKKMEHMRTVSENCDKEVNHKHETPCQLGNEVTTCIFKYAPELHFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G781</accession>
    <name>A0A835G781_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000443">
        <property type="protein sequence ID" value="KAF9407709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G781"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24308" checksum="B415D0CFC06829FF" modified="2021-09-29" version="1">MRLAERQTFWAFQTSLARHASNNPVRYMETQKMWRERDGISKRWQLIYKAPMDTALKYASSYLTVSTGIIGASSLYYAAFVFDKADMYNPVVIGDNVVIANSPVECLVYLGSFIALHIAIKVLISKYVIRMYQDGDEYLAVFRGHFFNSINTHKFHLKDFKKLSPTFVVSWGDARFSLGNKHGIILENYFKTPEHFNYMLNKKSSEKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G785</accession>
    <name>A0A835G785_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G785"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="443" mass="50755" checksum="397E1D0F4A3E71DF" modified="2021-09-29" version="1">MDRTIRYLNLTKPELIYEISIRGVQPMDRVEDLRTQITKLVQEYPADEVLESCFSVEEDLNGIRQTLSKVNISLSTLEQLFNKGIYERTRTYLNHIYFRMERLSKPVSGEHQQLFDTLQGQFLDYSERLNRVLSREQSAPKLDIPTMDPNSSTCNSPNISQPPLKADFIKVVCDRNSSAEILKHKFDGKSCVRAFITRIEELRRARDVSDEKMFKLAPEILTGDALHWFRSVKDSIASWSELLSCLREDFDVFDFDYKMMEEIRARSQGEDESITIYLAIMHGMFSRLTRLVPESDRLDIILHNIRPCYASVLAYRPDIGTIGELRDVCRNFERVTARSTNFKEPVSTSQANSVAPEFLYVSKKDPKGRSNHRVAALSENKLQCFKCGMKGHTVNTCPKSKGGSRSFQSPYRCYKCGLRGFKVANCPKCSKVKPTEGAKIDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7R4</accession>
    <name>A0A835G7R4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7R4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="27440" checksum="45E0A9DEC165E663" modified="2021-09-29" version="1">MMSARESYGDDAVGYVQLYRDNGICTVKCKMCPEHKVRTKAYNVTLIVNENDGEIISCECHDCAASAGGCKHAVAFLMWVHRRSEEPACTSVECYWKKPALSRVGTTLKFITIEQMTKTLVPHRPSTSALCEDFILEAKKRKINKCELLKYQNDFVHSDITRYSLHSFMVNLPQETKNDVGLLLSVMKSAFTSDIIKNIEEATRQQNKTNFWYELRYGRITASKAHELLTVMVEDDMVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G885</accession>
    <name>A0A835G885_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000400">
        <property type="protein sequence ID" value="KAF9408186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G885"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032509238" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="81"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="37109" checksum="63F1F2444CE74EFF" modified="2021-09-29" version="1">MLKYITSLFLILGAVNCDYFLNRINHLEYYRNRTNGRPSKSFSSFSTNYFNQNLVTKPGKGEKVQCGTRTVDFNPRRTGKIVGGTETPYGAFPWQVEIQMLDVDKLTFEHHCGGAVIAERLVLSAAHCFDKQPLNLEHIRLVVGEHRLKVQDKHEHRFLAEKVVLHPDFRKNGPHSNDIALVLVSRSGSGVQFNSHVRPICLPDDGVTAGKWCTVSGWGFQAENTENFAPILRAAAVPVLDLNTCRKSQVLGGRQQTILDSMICAGILSGGVDACRGDSGGPLACMNSNRWQLHGVVSWGSGCARRARPGVYTRVASYLDWIRRTASALGHKIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G899</accession>
    <name>A0A835G899_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000279">
        <property type="protein sequence ID" value="KAF9410079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G899"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MADF" evidence="5">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="558" mass="63481" checksum="4A0D1F288C1DA0B0" modified="2021-09-29" version="1">MEPVASSSRADLQTGCSLASTSQEITFIESQRGVPIILHAGYEYTKKRDNKNSSIVWRCVNRRCQGGMVTSNNNVTKILRHDICTPSIAINDIKEEIHRCKQEAKSSEGKSIPSVFNSSIKKLLDKGTDKIEKLPELSNVKNSLYSARNKAQQIKKATFKTPFEVKIPDKKESTYETAFALIKSQIPEWHPISFRTDYEKAAMNAIRNIFPDVICKGCYFHFSQALWKRAKALKMNKKRMFKKHIALCTALALLPPELKCDGWLYRMSKNLASNWIPTMPQVRVREKKVRGASEIDSDAIWDLEKCKDNWAKLRNAYCSALKRRKTKSGQAATQGTPWKYEDQMGFLRPYMEMRNTKTNLIPPSSPSTSVETITSELPAESPEVPESPPDFRSESQQSNLSSYSQRSSSSKKKPDLADIYDMMKTQHSLRQQKQQSKLDLDETDMFFLSMSKAVKALPKLDQTKIKLDLHMAISQAEIRNIEMERVVKTPLRIVSQTVVPPSNQPLPEPSRVYYYHNSPTEINEFSPESQSILDPEAQNTNSTGEENLSTYYSGVTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8T0</accession>
    <name>A0A835G8T0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000287">
        <property type="protein sequence ID" value="KAF9409961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8T0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="425" mass="47801" checksum="0C5EFE313358717B" modified="2021-09-29" version="1">MDEKLIDAVKKFPCLWNTSLSFYKCNETKDAAWEEIVKEIKYKDVKSAKYRWKQLRDSHRDALKRQKSKKSGQATTKTREWKYQKLMEFLLPYMANRDRESSYKEDISSPNNKDDSSQSSQYSLNQDDSSQSTEHTPNQVDNPDNLYEIASTSGISTDSVTASSSKKKKGDELSILIQKHMKNQEDFRKERQELKELLKPTDCDDIDHFFLSMAKTFKKLPDYMQVPLKRKLFNMISEAEESYMLSWYNQNIGYFSSSGTNASNIAGQMDLPPQLDPEQLGYSSSSGRNTNKTAGQMDLSFQLEAVQPASPGTRNTNKIAGQMDSSFQLEAVQPASPGTRNTNKIAGQMDSSFQLEAVQPASPGTRNTNKIAGQMDSSFQLEAVQPASPGTRNTNKIAGQMDSSFQLEAVQPASPGTRNTEPNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA22</accession>
    <name>A0A835GA22_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA22"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18287">
        <property type="entry name" value="BTB_POZ_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000051">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000042">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="642" mass="72570" checksum="40DD4897B9267BE4" modified="2021-09-29" version="1">MSSQHQYMSVNNTPSARIGDIEHISHLSEHIGSLCLSSEYSDVTLVVEGQRIPAHKVILAASSDYFRALLYGGMRETNQAEVELQAPLQAFKALLRYVYSGHMGLSMLREDTVLDMLGLAHQFNFQELETAISDYLRQVLALRNVCSVLDAARLYGLKALMDYCYNFLDRNAIEVLQHDTFLQLSVVRSATGLLERDSFFAPEVDIFKAVCNWFNANQLWVKSEAGQAQIEKILKCVRLTLMTLEELLTVVRPFSLVTPDMLLDAIQEKTQTKSTELRHRGLLLPEENVATPKRGARVISGDMRSALLDGDTDTYDMERGYTRHTINDAPDNPGIIVRLATSTIINNIRLLLWDRDNRSYAYYIEVSVDQKDWVRVIDHSNYFCRSWQNLYFEPRVVQYIKLVGTSNTVNKVFHAVALEARHTWRVPPLRAGLVEPLHNVATVDLSAVVIEGISRSRNALINGDTENYDWDQGYTCHQLGSGAIVVQLAQPYLLSSIRMLLWDCDYRHYSYYVETSLNNWDWEMVCDRTRESCRSWQVIYFKPRPVSIIRIVGTNNSVNEVFHLVHLECPAQVEDTRDDPAAKKQRPAHDNALNPIGNGGATAGGAGSPATSRASSSSSERSCRRGLPPAETATEAEERYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAB5</accession>
    <name>A0A835GAB5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="8">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_007526</name>
        <name evidence="10" type="ORF">HW555_008706</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000880">
        <property type="protein sequence ID" value="KAH9629041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAB5"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="9">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9629041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="519" mass="56473" checksum="5D8CD6057294E060" modified="2021-09-29" version="1">MASTMLGRIFVIKSNGFSKNKVYTITKIFSCASYSTASRSNKIYESAKEAVSDIQDGSKLLVGGFGLCGIPENLIVAVKDKRVSGLTVVSNNAGVEDFGLGILLKTKQVKRMIASYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGIPAFFTPTGFGTLIHEGGSPIKYTKDGKIAIPSAARHEQQFNGKNYIMEEAITGDFALVKAWKADRHGNLIFRKSARNFNPAMCRAAKITIAEVEEIVDEIDPDFVHVPSIFVHRVIKGEKYEKRIERRTVQKPAQAGKKSDSMRERIIRRAALEFKDGMYANLGIGMPMLASNYIPQNVKVFLQSENGILGLGPFPTEENVDADLINAGKETVTVLPGSSFFSSDESFGMIRGGHINLTILGAMQVSRYGDLANWMIPGKMVKGMGGAMDLVSAPRTKVVVTMEHTAKNGAHKILPECTLPLTGKNCVDMIITEKCVFEVDKEKGLTLTELADGVTVEDVLVSTGCEINVAEKIKKMGDVTQPDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAC8</accession>
    <name>A0A835GAC8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000285">
        <property type="protein sequence ID" value="KAF9409984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAC8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="296" mass="34218" checksum="483F913EAF526B80" modified="2021-09-29" version="1">MNFFFFFVSGYFWHITDFHYDPLYTSQGDTRRRRYKMLTISKFSQVTPTTALTSVNFYCELVQDCRRADERGSSGHHRALGRFGDYSCDSSLELIESAARYMRTRHSENVEFVLWTGDIIAARYTGNEDDKIQAIRNMTDLLSRTFSSHFVFPVLGHLDPAPSESLTNLWMHWLPLEALQTFKFGGYYTIEQKQSKLRIVALNTNLFSVRDSNSIQAKKQWDWLDAVLDKATANKEMVYIVGHAAPGSDSRHPYDMSADANAKYLRMVRRHAKIIAGQFFGHLHADTFRVIYDNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB08</accession>
    <name>A0A835GB08_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000198">
        <property type="protein sequence ID" value="KAF9412171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB08"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="82307" checksum="CA71286596F0722E" modified="2021-09-29" version="1" fragment="single">MKTMFGLLKMNNFRGFNKKSKATVIFHNVIDKDVQSMLQPFTVMQFILFCPRYRIKDNFITPNTTAIKIVSMLVTLTFILSNMHRTFSLYFYKNFIENTTFVYIASYYDCICSCLRGIVIFTTTTIQSEININFVLTFQKVHRVLNEETSFRRFITWNWTIVFFSLLNFLIGFSSSISMAGLSHARMLSCYFLIVFDVNVVYFFRILVVLEDKVLLWNIRAFNYHKTQHARDEEFSKQMFEAYLLYYIFEEFTHGLVYTQVAIETLKRSILVGDVHTAIAVPTAMLIWGLTKLFWHTIVTVRCEKFYIALQNLEDNCSLILMLNIPGSTNVNIQNTVDKDVQSMLRPFTVMQYVMCCPRYRIKNNFITPNSTTIKCISMFVTLAFTWSIVHRTKTLLVIVFIIATIQTKRNIKFVLTFQKVHRFLNDKTSFNHFTTWNWIVVFGTLSANIIMNTFLFVQAGQSIVKVYSCYFLIFFDCNIIYFTRMIKVLEDKVFLWNSRTSNFHRTIHVHDEEFSKQMFQAYVHILESYNIHKASFSMFIFYYFFEIFSHSLLYSQVIIEMMKNMTIDKLDDAIALSILIFMWQSKDLLWQTIVTKQCEKLYLALQRLQDTCSLILMSSCSVSRINNFVENDVQSVFLPFNIMQYIMFSPRYCIKRNFISPNSIIIKLFSMFATLVFIFSIVQRNIEVPLYKELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCM8</accession>
    <name>A0A835GCM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCM8"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="11">
        <location>
            <begin position="53"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9412358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="652" mass="74873" checksum="8691E189688E9947" modified="2021-09-29" version="1">MIGANKLLCKNNVCQKIIQQRNFTRKNIKDVNYQYLQRSKLPTMHFQKSLPRLPIPELSKTSERYLNALRPLLTTKQFEEAQQRTNNFIAKEGKVLQEKLIAKDKRNKHTSYISDYWFDLYLRDRVPLPINYNPMIVFQNDVRPEYNDQLIRSTNMLISAVRFMLSLREQILEPEVYHMNPKKSDTPLFRNVTRMLPEAISWYGAYLFKVFPLDMSQFVGLFGATRLPRQNKDEIFRDPKSKHVVVQRRGNFYVFDVLDADGNLLSPQEILGNLSKVMNDNSPISEYPLGVLTTQNRDQWAQQRVHLESTGNSEILRKIDSAIFNLVLDDDVINDDKRVLLRKYLHSDGTNRWFDKSFSLIVTGDGVAGVNFEHSWGDGVAVLRFFQDIYAETTKKPFIHPESKPADSNISVQKLEFKLDDKSKQFIDNAKREYNAWCDSLSIDYILYEGLNKAACKKFKVSPDCIMQLSFQAAHHLLKGSFVGTYESCSTSAFKHGRTETMRPCTVKTKAFCETLHSNNRSDDDLRSKLTECSKLHLELVKEAAMGQGFDRHMFALMKMAEDNNMPRPEIFDSYEYKYLNKSILSTSTLSSPSVMAGGFGPVVKEGFGIAYSAFPDKLGAAVASYKSHNNSTHYVEALHKSFLDITKILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD67</accession>
    <name>A0A835GD67_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD67"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13735" checksum="37C7E6206D0A28CD" modified="2021-09-29" version="1">MGRTSQKARPILLKLQDVALRDNIWHTKTKCKGSGITISEFLTKARHSVFMSARERFGVSQCWTREGTVYVLDFKGIRHRVTSSEDLDKIELQPSERDVAPPVAMAAGKVVVPRAKRAASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDD4</accession>
    <name>A0A835GDD4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prothoracicostatic peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000200">
        <property type="protein sequence ID" value="KAF9412114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDD4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40253" checksum="F94F0C8DD6D0B127" modified="2021-09-29" version="1">MQRVTFGGLLRMPRYALLRGRSVAVRTDHPGGGGGRRRPPRASTATGNCSKQFIPQPPVHTPACSQTDNEIELSEEEKRAWSSLHGGGGWGKRGWQDMSSAWGKRAWQDLNSAWGKRGWNDMSSAWGKRAWQDLNSAWGKRAWRDMSQSPWGKRGWQDMSSAWGKRGWNDMSSAWGKRGWNDMSSAWGKRAWNDMSSAWGKRGWNDMSSAWGKRGPEKWANFHGSWGKRTAEPDYEEIDAAIEQLIPIQQLSESERMEAPEKKAWSALHGAWGKRPVKQAQYNSGSYYWKREPAWTNLRGMWGKRSPQADADAVDDDHGNPARSHTSLCLSLSTVCLCLTQSCSCLFHVVTSKACNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDP5</accession>
    <name>A0A835GDP5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDP5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="158" mass="18990" checksum="AED4EFC6648F6970" modified="2021-09-29" version="1">MNDHFEAKRLVSTEHQIHSKPIKMLVLLKDPHYDWQTQNRCDPFTSEKRLSGHYHTTFKKLVIHRRWKKFYNCYRMSYSSFQELLLMVKPELTRQNTAMRSCISAEERLLITLRYLATENDNNMNNALDGTTVREMFKDYFNSDEGSIPWQNDIVNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDY7</accession>
    <name>A0A835GDY7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_008449</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDY7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF61">
        <property type="entry name" value="RH14937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9413283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="23240" checksum="67DF7BB48BA0BA07" modified="2021-09-29" version="1" fragment="single">RDIYTWALDHRVHHKYAETVADPHDIRRGFWFAHVGWLVLTPHPAVEDRRIALRPTCADLIADPVVRLQKQFFIPMFALLNIAIPIWVPWYCWNETLVNSFVISFVMRFVKSVENSLVSLAALGEGWHNYHHVFPWDYRTSELGKLNISTGFIDFFAKIGWAYDLKAATTDMISKRAKRCGDGTFGESEEPYPSSEKCHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE26</accession>
    <name>A0A835GE26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000141">
        <property type="protein sequence ID" value="KAF9414149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE26"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="53"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33626" checksum="A7417C91100316C9" modified="2021-09-29" version="1">MCGAPTARPTRRDVARRSLDCGAPSPRSCPANPATIARPHPYNTKMLGIDTEALILAVKKRPALYNKNDPYYYNNKKHKSKMWFDVCKEVFAAWDNFNPQTKVEQGHELQKRWKSLRTCFTRELSLQKREQAEPSKKRKRKRYEYFDMMSFLLETGGDDEEGPSNTVKDSDESSSDPLESIKNEPAIYEASLQTDNSAHFEVETEIPAQAGTTTASYLRPVYDRSENLEDKILDMLKEIKKDEEDEDRQFMLSLVPSFRKLKAKQKFEARIEILRVLKDITFRDDEEPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE88</accession>
    <name>A0A835GE88_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small integral membrane protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE88"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031933">
        <property type="entry name" value="UPF0767"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28599">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28599:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15990">
        <property type="entry name" value="UPF0767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10024" checksum="E81DA16B12FAF9D3" modified="2021-09-29" version="1">MWPIIMQFLRTNAPYFTLPVAAVVGVIGYNLESLLSDRYTPYNKPVQDQRVERLIDEDVLSDPTNVQKLKYKENVLGRNLSPSLQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEC3</accession>
    <name>A0A835GEC3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_005481</name>
        <name evidence="10" type="ORF">HW555_007696</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000606">
        <property type="protein sequence ID" value="KAH9634488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEC3"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9634488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13879" checksum="EEC27A58301DD141" modified="2021-09-29" version="1">MDTVVKNLLDEEPEEEKKGLVIFGRDVSKIPCFRESFLYGIATGTGVGLAAFIKTSRPMLSQHIGVGTFSMTTMIYWCYCRYQWSKQRFDAQLLQDALKDKILYEGTIVEKELEQKGVLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEF0</accession>
    <name>A0A835GEF0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_015480</name>
        <name evidence="8" type="ORF">HW555_007650</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000548">
        <property type="protein sequence ID" value="KAH9635480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9635480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="192" mass="21000" checksum="AD3306700006ECBD" modified="2021-09-29" version="1">MSHNVKILPGATVCEDCTLEGDITIGGGTVIHPRVTIIAEGGPIIIAEYCIIEEYSTIIHKKSDKQENPPKPLFIGAHNVFEVGCKLESPCGHIGESNVFECRSFVGVDVKIGSGCVIGAACRLTAPQTLADNTVIWGSDHHVREALEKQPSQLLQLDFLSKVMPNYHRLRKPNVHKRQPSTRQSQESSPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEP0</accession>
    <name>A0A835GEP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucokinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000155">
        <property type="protein sequence ID" value="KAF9413554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032696450" description="Leucokinin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39136" checksum="8D1ADBD48132D513" modified="2021-09-29" version="1">MLHQWIIITFSWLGTVRPQYINNGGLSNGYILDSLDSNIQYPIPYYFNLPSSRNDYETAQNMLQNIPISSYEETKADILRKRRTPEEQDEIREKRWLPNMLDMDQTLYAQEEQLGNPGMNSIEAFDENGTNLLDVKDKKYFSPWGGKRDKASIEHMWTWKRASNIREPSMPKRVRFSPWGGKRSGQMIYKPGSKSSKIIFSTTIPELTRIVSNYIPNGNDRFNFAGFQFIPTLDKRHPIKILALSTKTNERTLREAMPFKSFLDSLPKIFKPGHPYLDVNLKKDGKRKVKFSAWGGKRSPPIIGPIWTPAPQNLKESTLDTILLIRNSQDKDESTSKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF10</accession>
    <name>A0A835GF10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxypeptidase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000166">
        <property type="protein sequence ID" value="KAF9413253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.10">
        <property type="entry name" value="Anthopleurin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023355">
        <property type="entry name" value="Myo_ane_neurotoxin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032277253" description="Carboxypeptidase inhibitor" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13026" checksum="082512BCF97ED82C" modified="2021-09-29" version="1">MCNSSFVFILCIVSVLANQDFKLLDSIKQEQPCLTMGGVCTIAGDCPAGHLVEERGLCPTQQKRGIECCLGLSVKETRCSKRGGECFPGRDACNDIVRYSEATDCPKDTTCCILVRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFJ1</accession>
    <name>A0A835GFJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="JACKWZ010000105">
        <property type="protein sequence ID" value="KAF9415665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFJ1"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="426" mass="48560" checksum="F46E8D07F8396F41" modified="2021-09-29" version="1">MNVPYQDDSEYPKSLDNNDPMGHFRQRFFLKKDSIYMCGNSLGLATKDAEECVLEVMERWKEEGIKIWTVEDNKYYLYSRYLAKLMAPIVGADPDEIAVFGGTTINIHQGISTFYKPTKDKYKILVDDINFPTDRYAVDSQVLLQGYDPKDAVKVVKSKGNFMDEDDIINAMTEDVALIFLPTVYYRSAQVLDMVKITKAAKERGILIGWDLCHGVGAIEINLKEIDADFAIWCTYKYLNGGPGSSAAIYVNRRHFNRLPGLAGWYGNKIETQFLLRQEFDHQQDANGWQIGTPNVLSMASLEGALKVINEAGVSNMRKKSLHITGYLMYLIEKKLSAYGFTIGNLREDSKRGGHVCLEHDEGYRISIAMKKRGIVADFRDPNVIRVTPTALYTSYEEVYRVVDILLDIVKTESYKEIDRNRNYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFL5</accession>
    <name>A0A835GFL5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="29484" checksum="4602C4AF90CEF67E" modified="2021-09-29" version="1">MLMPAEAHTVEENSSDEETAAEETDKFGVEIDSINSIEIVEFENKDSEIEDIFNASEDDVQSEVSSTTSHDKSETLRFDPLSIENVHVSPELPAHLRCSAHKLNLCATTDAGKVLRNQNTRLSKTHERVINKCNKLWNAAGRPKSAEIIQTVLGHTLSRPGDTRWNSTYDALGQIYAIKDKSIPLYETLKISCSSQLRHNEFHYIQEYLKCSKPIADALDILQAPVERLFSYATMINHPKSHKLSDEMFEKRVVLKANLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFR5</accession>
    <name>A0A835GFR5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFR5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="139" mass="15832" checksum="3E8490203B4DDE16" modified="2021-09-29" version="1">MINSALESPPLFLVEERIKTFKNWPFSDKNKCNVRNMAEAGFYSVATGADDADAAKCFLCGKELDGWEASDDPWAEHKSHAMKCAFVQLGKKEDELLLSEFLSVIKQYMINETKRIAELAKERIDEKAKAVRRRCLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG98</accession>
    <name>A0A835GG98_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG98"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF15">
        <property type="entry name" value="OSIRIS 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38840" checksum="8FD965E2B79536D7" modified="2021-09-29" version="1">MCTAFRIYVLSVICVVVATGNVHGPRRSRRMEVDDSAQNEIDSGRAEDSSWWWTAELSVLQKLYDDCSAQKHMSMCLKGKALMALTRAVEQESVQLADGLTLVKQADAPSAVAEPRFFPGMSTEDKLDAMLRTRFEQLMSTHTISMDLATEGRGRGKKVLPYLLLGIFTTVTIVGGMALKTLAAIAGKALIASKVALTIAGIIALKKLFSHDGAPAETTFQYLNSKAEPVCGEASKSRRGGSVLLRRADDGERVALVSTSGASARAHRHTATQQHCHHQTRPSSPPPGDSIAPTHKITSKPKYRPSWTSFCDSMVVHLDFKSMPLSLHALVEKSPRNVSRFSVNVGATAMNVESRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGJ8</accession>
    <name>A0A835GGJ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Josephin-2</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Josephin domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_006224</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGJ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000003">
        <property type="entry name" value="josephin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF0">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="25711" checksum="1B1AFA30B2C267A7" modified="2021-09-29" version="1" fragment="single">VKELCALHALNNLFQMRATYSKSELDAICSRLSPNVWINPHRSMLGLGNYDINVIMAALQKKGCEAVWFDKRKDPGCLDLSNICGFILNVPSDYKLGFVMLPLRRRHWITIRQIQGNFYNLDSKLESPQLIGRSSDLIAYLKEQLDSKEKELFVVVSKEVEEKQLWMHQYTMDSNKQSAQNTGLPHTDGQCESPVDSVSSLSQYDYRNRDAECLKLTEVSNCVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHC2</accession>
    <name>A0A835GHC2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_007145</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000117">
        <property type="protein sequence ID" value="KAF9415111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHC2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9415111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="104404" checksum="3D595B476842E271" modified="2021-09-29" version="1">MEVVLYNSNVCRLCGEENDNGTLLYSSEENNQNLFEVINTYLPIKVSDDGQLPRTICPGCTIQLEATVEFLNLIINGQKVIRELHNREKEYKRSLLLPPTEQDIITDKIIYEVNTSDGVYHVEHPIALQVAGFEKPKRKRGRPPKKPKTPEELAKEAAAKEHEAKLAKKTEKEEEPSGKRRRKTPTRFKEAVQGKELERIFKEEGVTDGEESEIENLKGQLIDKKPPVPREPEVIGHLEESGELVVVVKGKGRGRPKGPMIPTRKECAICGMEFTCTGRYMSHIAQHGPVLYQCEQCSETFTTRLSFNNHQSEVGHTGHNIIPCKKNTERNRNKKNAKAQLETVSVVEEDPLSITDMSPVQTIDNVILPVANSLPDLDPQLIVVDNEVSASDSQRTANPKIEISSPIADNDVKLVDSSTDVTVTEKSDEVDQVVTTPSGKPRLKCPHCDKTFSSKQSKSLHIKATHQGERPYACAECGARFAYPRSLALHAVSHRRHRSTPAKGYACDLCGKVLNHPSSVVYHKEAEHAGQRYVCNKCGKCFKHRQLLQRHQLVHSQDRPYHCKLCNSSFKTKANLLNHSLLHSGVKKFSCDICKHKFAHKASLTLHMRWHTGQKPYACNICGKSFSQKGNLSEHERIHTGEKPFQCTQCPRKFTTSSQYRLHVRRHNSEKPFVCSCPAGRGRRTCVARRARGRGGAARMHRCVECGRAFWERWALHKHARRHTGERPHRCPHCPRAFADCSNLNKHKKQVHKQISLLATSNQHPLPSPVTLKVELPDSPQVQLETEQTVSLPDSSPVKMLEEAAEDELEERVIYVTYDVDDANSPAFHILDPEQVTDEQGNPLHFTMQDGTRLAITSADGKSLQVITQDGQTIPVEINGFADEEEVDNPDTIVHQLNLQKSIDSNVSSPVTHYFTIRESTSQMEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHE6</accession>
    <name>A0A835GHE6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000103">
        <property type="protein sequence ID" value="KAF9415748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48366" checksum="D62CF4446011F9A6" modified="2021-09-29" version="1">MVIECDVLQSQVEVLTQSFSPMYTETLLCLLGARPGSRISAADTYRRRRHEVKNHDDDAYDYNDFKRMSKNTNAGDSPDHEQFWCTKDAVPSFSGQDKTYPVSKWIQDIEDNGDIFQWSPIQQLLVARRSLTDGIPDLESNKIMLYGVTTYSDLKDKLKIYEMVKEKMKVRIPSTPHEATPRPPKQIYFTTNECGAIDDVMHDVHVVNTDMKCATIHERNATYDSDSSNRSIDVIDRDVKDNNNIALFTSRSRQKPLKTVKICGKTAEALVDSGSDINLITDEWRRQLGLSVNSDSVSVSGLGFSIIKTSGSCTMDIIIDDRNYENVKFYVISKSEMPFCIILGNDFLQRVTMCMSGNSVWFGTKDDEWLNCMLSEVNTKDAEYFRIPLTEVPWTWNWVVSAHRSPLWRSPVASANTWRFLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHI7</accession>
    <name>A0A835GHI7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000058">
        <property type="protein sequence ID" value="KAF9418257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHI7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27488" checksum="244DE3762798F303" modified="2021-09-29" version="1">MSQVSEIISIHKNVQESLLKRMGDIEAQIQSAGPAKDTVARIAEEFRAFRELVFDMLKMLRAQVIECCRSIDDLEMRSRRKAAIFQGMPELDNEDCSGLILGVINTKLGLDLPVSAIKVCHRLGASNKDHHRPILVKFSSLDDKASVWKAKTRLRGTKISIREFLTKPRQEVFSKARHHFGMRSCWTRDGNIFLKTSDGNKHRVTCLEELSPLLIQYPRAPGASQPEARHGAGVNSSKLKDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHN8</accession>
    <name>A0A835GHN8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family. AFG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHN8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000567">
        <property type="entry name" value="ATPase, AAA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="257"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="515"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="744" mass="82848" checksum="8535708689C50B5E" modified="2021-09-29" version="1">MPPKGPKKTLWVDCERCGCSITSNDKSMHVELNCGKDQLKCPYVEDGKLFTWLQRTGVAPDGAPRDAVLVHPSAGTLIGAVIGCPLQLSREGAPMMVKRMWPSKASAPAAVILPAADLCSAWSSDSMKVTVSVVQEDIPKVSHITVKLNNHKTESDICDILKQHFYSNFICIGSILVYYYFGKKLEIEVLDIKSDKLDHKGWFVLTENSTWSMHKESTPKPKKKSQTLGGVDDILEEIKTFIKISFNMDGLAASFQPTRGLLLYGHSGIGKTAICKYLIENLNCFHIEINGPAIFSKYFGETEGTMRSLFEKAMQNQPSIILVDEIETICPKRSSGSTEQERRITSAFVNMLDNLHAENSRVFVLATTRKPENIDPMLRRFGRLDKEIEIPVPDRIRRKEIVYSLLKHLPNKISSEDLENIADLAHGYVAADLVNLCTQATMKCIKRSSDFVARDDLIAALTIVRPSAMRELLIEIPNVRWSDIGGQDDLKLKLRQAVEWPLKHAESFRRLGVRPPGGVLLYGPPGCSKTMIAKALATESGLNFLSIKGPELFSKWVGESERAVRDLFTKARQVAPSIIFFDEMDAIGGERGAGEAGVHERVLAQLLTELDGVVPLNSVTILAATNRPDRMDRALLRPGRLDRLIYVPLPDFETRLQIIELKLSKMSVSDDVNSHVLAIKTEGFSGAELQALCHEAALRALEKDLDCPEVTMEHFEHVLKDFKPRTPESLLKVYQEFALGQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHX4</accession>
    <name>A0A835GHX4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_007036</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90234">
        <property type="entry name" value="Zinc finger domain of DNA polymerase-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="479"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="781"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1265"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9415287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1481" mass="169469" checksum="15FF18D5ABDA8741" modified="2021-09-29" version="1">MADSLAGQRAKRQKVDKHGRLSAFEKLKQLKGKGVKNKYDVDEMENVYDTVDEREYSERVMQRQEDDWIEDDGTGYVEDGREIFDDDEIEDTYVASSTKESGRGQKRKARVAPPTSKGNIRNLIGSMPTKKKEDVKISEDNILSDIMSDLDGNASAAVKPKPVVTKTSIVESSKRDAQNYFKTLSSVAKKPTTTLLNQEQPAIKVENKENLVSSDQPAAKKSNCKLIVQQNGETSKSVTDKSVPKKQEWKIDREIKEEIEDSATQNIEEFHTQDLNFDDDFSNDNTPKPAEVEIKKEILPNTGETITDVAEEFLNEDFEIFSTKKESPKQLKPLTSTWTDQMGENQVAATVQVDGQLPLQTNESGEKILKFYWLDAWEDRFVKPGVVYLFGKVYANPSNKKAGCVSCCLVVKNVNRQMFLLPREYKLDSVTLEPTDQEVTMMDMYAEFNSAVASELGLKEFKLHFHRLPKDKKYLTFSHIFGANTSSLETFLLERKIKGPCWLEVKMPEQVVAKVSWCKLEAACEKMEHITVIRNGADLEPPPIVVATINMRTAMDPKTRKTKILMLSCLSHTNFHLHKPPPNPPFQQHFCVMTKCNEIWPIDLKQALPQYKATKLTKCDTERELLNYFMVQFWKMDPDLVVGHDLQGFQQDLLIGNILDLHIPNWSRLGRLKRSVAPQKKYAAKDAFLGRLVCDIKISAMELIRARSFDLDTLCVNVLKMKEGERVEVALEDLPRYYENSNDLFQLVSLSMQDASYILKMMCELNVIPLALQITQIAGNIMSRTLLGGRSERNEFLLLHAFTEKNYIVPDKVYGKKAAADDDDDQEDGTNNASKKQAKKKAAYSGGLVLDPKKGFYDKLILLMDFNSLYPSIIQEYNICFTTIKRKTASSSDDDVANLILPKNNTDLGVLPTQIRKLVESRREVKKLMKTPDLSQDQYMQYNIRQMALKLTANSMYGCLGFTHSRFYAKPLAALVTMKGREILMDTKEIVQKSNYDVVYGDTDSLMINTNCLDYDNVFKIGVDLKKEINKKYRQIELDIDGVFRYLLLLKKKKYAAVLVTKNKNGEFVFTHEHKGLDIVRRDWSQLAAEAGKFILSQILSEQSADERLESIQIHLNKLKDDLVSGKMPLSMLTITKQLTKNPNEYADKHTQPHVQVALRLNSKNSRRFKKGDVVPYIICEDGTANSATQRAYHIEELKNLEHLKVDFNYYLAHQLHPVISRICEPIEGMDPARVADCLGLDPSGYRQIIRRDNTNTETYEVENEHEKYRQCKDFVFVCVNESCKTENRIREAVVKLDKESITFLDKCQNDKCTLRPVDYLASIQNQLSLQIRQYHAQYYAGWLSCEDPACGHRTVRLPQTFAGGYPLCRSCEKGVMFREYTEKDLYLQINFFLFLFDMSKNSNSKIRITPQITNAFQQLKEMVVEDWLAQSAYSIINLSKLFRFFTLDPKAGNKVKSEPIEIDILPETEQIDALLEMGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI24</accession>
    <name>A0A835GI24_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI24"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="18571" checksum="3233610D20364BD0" modified="2021-09-29" version="1" fragment="single">FGIYLFPSWYFAMGSKVLLFCIAILAVHAVHARVWEFGADDKPAAIVVASYKGRFSLFEKEQKIQLIIPQCFILTYVNVEVNNRISSPTVQLNSQTNVVPPCNVVTYVEVKVDNLISTPNVFFNPQTNLVTISYKLWQNGHCSYDIISKAVWIQGCDTVATTDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIH1</accession>
    <name>A0A835GIH1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIH1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30282" checksum="EA21C756F0A52C15" modified="2021-09-29" version="1" fragment="single">AYPHSHANHGAHRAAKRGAMRAATVNSPHSQGSRRAHSIVRALDAYTLGMDSETITASALLLCSLAIYSYALKKKRIIQKKHRKRRWWITTIHRNRSSATMEKLLNELVAEPSDEFKKFSRMSLNDFEYLLSRISRRISKQDTQLRKAIPARIRLAITLRYLATGDDYGSLHYLFKVSPQAISEIIPEVCHALCEVRSSTSLHIYTPPGSIDMYDDDGVLIQPGSWRTNQDNTSAFRNLRTVPRRPANNAIEIRKEFTKYLITFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIH2</accession>
    <name>A0A835GIH2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031736">
        <property type="entry name" value="REXO1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15870">
        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="438"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="599" mass="67505" checksum="445DCEBC08AAEF06" modified="2021-09-29" version="1">MEEEFDMESDEDAIALECKKIFDEYVPVEKPKIIEDTNKIEDTNEEETVVGKKRISRAPEKGVKVAPKTPIKPDFKLSAAQAMAQRLAKVRDYHSARNASVPSDNEKPLSKSNFTPPTTGNSKIRIAHVPYASTLLNAKKTISPSQKVPTMNEPSTSTTITQTVKKGAQRVAHVPNEKFIDRPGVLEPLGSKIPANIRSTYLNMMIDECLKLYLSAHDAYARAQHEELSTSKKCSTVQIYKNSAVLAVSRLRKEFQESKGVKKSGSDCVTLQKVPGMTPGKQMGSWSIEGKNRKNADNSHEFVGAKLYSNIKKWILSEEQLKQNGFPRPHESGQKGRAIIYGQNKQKPPKGLFRTCCRCKKDYMVDKFGFAAVKEECIYHPNNKYRIRGEARYQCCSQDGTSDGCCIAPSHVYEYVDFENLKGFVKTLPPEKDMDDYGIYALDCEMCYTTHGLDLTRVTVINSSCKVIYETLIRPLHPIIDYNTRYSGITEEQMQGITTTLLDVQATLLTMFNSNTILIGHSLESDFKVLKLIHDTVIDTSVLFPHKMGPPYKRALRNLSSEYLKKIIQNSVDGHDSAEDATVCMELIHYKLREDLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJE7</accession>
    <name>A0A835GJE7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17270" checksum="DEDCB3DCFE06028B" modified="2021-09-29" version="1">MCLPFDEDDKDKSVWFLDHDYLENMYGMFKKVNAREKVVGWYHTGPKLHQNDVAINELIRRYCPNSVLVIIDAKPKDLGLPTEAYQAVEEVHDDGSPTTRTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGSLSQRITNQLLGLKGSALSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJJ7</accession>
    <name>A0A835GJJ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">trypsin</fullName>
            <ecNumber evidence="8">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJJ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032456545" description="trypsin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="31"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="29930" checksum="7A09D63C1FBC88E4" modified="2021-09-29" version="1">MRTRVARTMRAIILLAILGSALAVPRNPSRIVGGTVTHIERYPYMANMQYSFFGTFFTQSCGGSLLTTTSVLSAAHCFYEDFEWQWRVVLGTSFRSQGGSVHSIQRIIMHPQYIDEILNNDVAIVRLNVPAVYSDSIRPARIPGPEYSLADGSIVAHVGWGRQWTNGPLSEQLLHVHVNVINQEVCAARYAYLKTQPGYEEWPDINEGMLCAGKLDVGGKDACQGDSGGPLAHHGDIIVGVTSWGFECGHSFYPGVSARVSHYTDWIVANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJM6</accession>
    <name>A0A835GJM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein L55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_003790</name>
        <name evidence="1" type="ORF">HW555_005145</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000093">
        <property type="protein sequence ID" value="KAH9644291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJM6"/>
    <dbReference type="OrthoDB" id="9986315at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.20">
        <property type="entry name" value="Mitochondrial ribosomal protein L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018615">
        <property type="entry name" value="Ribosomal_mL55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044884">
        <property type="entry name" value="Ribosomal_mL55_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09776">
        <property type="entry name" value="Mitoc_L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9644291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13384" checksum="50428223D1178667" modified="2021-09-29" version="1">MNTKVLLNLKSSIVNLCMKSYLHNNVASVTKIHRDLYTRMYPTKVVLPDGASINIRYHEPRKIIKLPIDLSKLSEEERKLRLEKRKPKKKVKIVDDIDDDYNAKKYLKYIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJQ5</accession>
    <name>A0A835GJQ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="30206" checksum="41FF0A221A5D86FA" modified="2021-09-29" version="1">MEQARRDLMELALKREEEKRNRIIMDAKWEDLRKKENLLKESFISFNKFIRENQEKRDRAERKMQADNEVLERKTKETEAMRQRDYLMSVVSNYPEFKQPLDVLNRYEALAAAKSTLADRQERDLEMLENARQEIASLTEEKKLFIMGLNNTLADLRWRYDKIRNRVLKWELALNRLKETAARRHVELCHVRSAIWSLYVKICKQKGLSIDVATDDFEQQLVVIMRALLELRRIYKIAQKRSKDKDIESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJY0</accession>
    <name>A0A835GJY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF163">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="138" mass="15851" checksum="D7ECDA10A4218C34" modified="2021-09-29" version="1">MHVKTHNGEKYACPHCPKTYTRAAYLKAHSLVHTGVGKPRPFLCTYKGCERSFPSKYSLIVHTAHAHTKERPYKCDFCYKGFATATGLKIHLECHEYKELPCNICGKKLKNKRVLQKHMKTHDVDANDMILETVDQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK18</accession>
    <name>A0A835GK18_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13112" checksum="89EE595F899E1EB4" modified="2021-09-29" version="1">MKAQYEDVCDEGNCETVLETPNVSNDKVSFEHLKKVLSQLATQFELSLSNDEQKTCSDESEDVVSTKDKQSSEDGSIEGPPSCSAKIDTNNSKESSKPVVKDNVEDIENKSDKKTEDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKX8</accession>
    <name>A0A835GKX8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Splicing factor ESS-2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKX8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53834" checksum="8BC34F36BA5D2579" modified="2021-09-29" version="1">MSKENNISKPGAAALENMKLLKHESSIFKVPKVPKKKDNVKKTQVLDEDVYVEGIAKIIQRDFFPDLEKLKAQNEFLEATENKDYARLRELTRKYSGQRPPTEPYNSPATFDTPHLDRPFSTTTPTRDHSDSDTESVSRDKPKDITDNHSLDSYLASHTSEDNASYDRVISLENKKRATKLATQLQAEVTSSALADAALALPSIEQQADQTERPHELDTWRYKAKNYIMYVPDGAESQRPPPKPELVHQNTRLKAEPFDHVKNKEAISAIARSQDASVTGKIGVDGVSISTEKSGEAYSLVATPSPRPGEGPDQSPIMTWGEIEGTPFRLDGGDTPLPAVGAGAAYRMLEGGVRERIALQLAEQAAKRRRPTTPRIAPPTPSFRSNTERLASMSPAARKLAAKHLLSPRLKLTPNDMGILSHATPKRTPTPQRPLVATPIGKKTPRPSREGSVNNNMTTEDNNLTDNLLQINVAKRTRLKAQDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL12</accession>
    <name>A0A835GL12_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL12"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF28">
        <property type="entry name" value="SIDESTEP IV, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="153"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="252"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="528" mass="57720" checksum="407861648F7960FF" modified="2021-09-29" version="1">MAYLLQFSDNNATVSTLNLVPMAEDHEKYLVCRAENPRVPNAVIEDRWFLNVQYVPIVTLKLGSNLNPSYIKEGDGVYFECSVKANPKTKKLTWYKGAKEIQHNASAGIILSDQSLVLQSVTRAAAGDYSCLAYNNEGSATSNPVSLQINYAPMCKTVNDGEVYGALKMETVVLQCVVDSSPPPTYFSWFFNSSGEQTEISPSLYTVYGNTSTLRYTPTTDLDFGTVLCSATNSVGRQETPCLYKLVAAAGNPTALQNCSVVNQSSDTLLVECLEGFDGGLPQVFYMEVLELPSLMVRANVSSNHTPTFEVHNLDSRSSYTLILYAANAKGRSEEVTLYTVAIRPPDKYTAGVSTSIPLSPMLVSLLSVAALLCTGVCGVITALYRRHAARRHDIDKHPPSTNALYMEQSVESLSKQDNLNTYCASPKLDYCSQYELKMEGSGEDTDPDIIPCHYDKKPIGEYSKLSTPALDSDPHRIFSERPIIPSSASSVSICVVNRGVTARSADISAARRPEVVTTARKVRESCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLH1</accession>
    <name>A0A835GLH1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">trypsin</fullName>
            <ecNumber evidence="9">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_005963</name>
        <name evidence="13" type="ORF">HW555_004563</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000772">
        <property type="protein sequence ID" value="KAH9631192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLH1"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032549480" description="trypsin" evidence="11">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9418735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9631192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="263" mass="28141" checksum="4E879EBB1161BD83" modified="2021-09-29" version="1">MRVLILLALLGTAFAVPKSISRIVGGSPTTVEQYPYMSNMQYGLWGIWWFQACGGSLLTPHSVLSAAHCYFGDVPSEWRVRLGTSLASSGGSLHSVSQLILHQQYNPNTLDNDVAIVRLSVPAVYSNSIQPARVAGSGYSLPDNSLVTTVGWGTLSSGGSSPEQLQHVDINIINQQICAERYAYLKTQPGYAGWPDITDNMLCAGILDVGGKDACQGDSGGPLAHDKDVIVGVVSWGFQCADAFYPGVNARVSQYSQWIAQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLS3</accession>
    <name>A0A835GLS3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1523"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1542" mass="176004" checksum="5D50879D3D107070" modified="2021-09-29" version="1">MVAMLEVAETRNNDYFRSFLPAVNSPPVPHRDISAPTATYRPYTEEYATVQRRVERPTQPEEPERKKDKKWSIGKLFRRKKKDDESGTSSESDEGVSTRSPSKRKSKKKKKTPAVNNFDHIVIRDSRRAQSLAKSNLRDVTDDGVLSDPSAGFINYRAKTQDMYRASKESLSLSQREDNSNRSLGPSLESTSRKTRKGRLKARVEALRNSMRGDSSSEEESLKSSNSSLMIRFRSEDSLMRSRDSSLNKRSRSARNERYIKRLSRDEENQLNKEAELLQQGYTKAEVEMLTRTPTSQSSGYGTCKRDQTQNIKTEQLYANDANRRPMKSESISSFPSTQSYPSSINFNAKVNNEHINYSIPTSNINRDMLYANNNRERSVSNQYENPENVMCVKFPLGNVTNVKREEKAPPVPPPRDMQRKVATPISMYYENNPMIADRIANTQQTVLHGVPNNDFERVMRRSQERSLSHSFNGLRRPISNSEDHIAMQNNEYIQNFQIKNEQPRRPASVSAEPNHYGLYANSPPWRKSVGPTNIVKPEPVQLRHDYLYYADQSPRSRRPISVKTSQNGYENQYLSDSQTSQNVAESVYRRPRNASEFWKKIDDAERQRRQQNIYANSRSSSDFSNSTQVNRVAPYLEQNKLGHEYTDIQNKNKNPFKTSSVDTTDGAKVWKATTEYKRSVTVDPPKTVTSPTSKTHVRHKSDTYVPSVYQMPSDDEKSSERRKSTNLDDALNELEAIYNSLGLGDEDLLDRAERRELMTPKFNDHFNDWNGNDDEIQLRSQPTTPLRRVQRRSTLPDKLQDDMAFRRMNSLTKEKPNYKDAQAQISYMLASPVFVPYASDDDRQSERNEPDIVYDDVVYRNIKQTNSRLKTLDPQPPFGIPIGPVSPAPQSDYLHATPENKGRSRFVPRRSPDLVSDDLAYRSLRKDNRHSSHFNGEDYTGLINNNHSYNEYSYNKDTASNLKKKRAVRSLSANIFTMIQKEIDDALNMSKMATLQKTHSNSDVMKRLRNTFESNDNEQDHYPRNKVKQRHNTVSLFVNNTHAPTHHFAKDDSFIHSDDKHLAKPPSCDKSKSSSPSNRSPQASKRSSKDEFQQVLSMLAQEAMDTSNKLGVALAELDKNRNNNEKKSDVQSRISDSRQTFLNGLTCKSLEEPAPEVKLVKVHSEVVSESKDDKPVTILNENKTNEDSKGKKTEDSLLAISDQLHKVEDQLKHSFEKELNFEDESLKFSNYIAKAEEQLKAQETTVVTPETKMIPDVIPLTIKEDAIEIENVTQKQDDIELKPPIINSLNPFLNSDDKIKEINEINAFKELKDGISDLIAGICQVNEKLFTQNKGPKLDNSNTNPEKISGITEATEKLNQVSQSICSQEVPNRASVNLSIYEDDLETKKDTAADSTEYNSSEELATIFQLDSNAKSRAVSESQNDSDNKIRGELSSPKLVQTMNQQLRRLSVDQTDDCAPSQSNSLPTNVVPWRIKRQTNNSQKENRGDNAQSKRDWHDSGTLMLACTYTMMFSQHLADLDWLTLLGLLLAMITIIAMLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMB9</accession>
    <name>A0A835GMB9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMB9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="2">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="1">
        <location>
            <begin position="314"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="839" mass="95298" checksum="8D97CCCAC5DE5106" modified="2021-09-29" version="1">MKVTLTDNPRAALETHITALQSESKMTRKQALLKINEEIFENPANKNCDLTVVFPEVYAYVLKSFSDPSEACRETSALIISNFIDKLPLNDYYLTYILPVIVRRIGCPEIIEESEEIRLVLIKLVRNILEKYKVSQLLSPFINDFTSILTKTVTDPFHLVKLEASECIIMVTRVLQRDFHFQSESYVKPILSNFGHRHFRVRVAAIKAIGSVVIAGNAKCFELSISALAEKLFDESNEVRMQVTLEVGHWMLAYRDRYSFWHRMLPLILTSLSDVIEDIRTTATSLWNDIGRQYMEENEEEFKKKTDFLKDVPKHYPDVTRPNFGCRALVQSNIGKIVPAINREMDGWQADARLRVSQLLCWLILCAEEGATQHANAILKAMLRGATDEDPRVILEIKRAAELFGYFIIPSTWWPLLEAEVDSWAALLVIANIIKGSRPELLQEKVLPKYQTNLLHMCEALLDVCGEACTEVADDLFTINFTVLAMPYDERIQFMAIANLDKLRYAEKCGSTLISLYDKHLGKMLASITSDALTWTQLSPDKCLLECAMLNAGSAMGAQLHLIAPLLKECLATPKVDPEVKLKIFTTLSTVLLRRDTNFSRCDNDKLEAFLKIVIEEVIMPNLVWSAGRTAEAIRTAAVACLCSALQENPYNETPLTEEKRGDGDKDEKVVNLFPSKESLEPFLEKMVPLLVGLADDNSTLTRQHTLRAVCCLAVLARQRDCFSGDTLHKLYYVVLKRLDDSSDKVRSFAVQTVVTLFMNRPQLYDVTLYGAHIDALYSAMLIHLDDSDEDFRKQMLEALIKLSDIDPKTLMKKVKANIHLYRNKSAYEKLSSHIEKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNM5</accession>
    <name>A0A835GNM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_004795</name>
        <name evidence="5" type="ORF">HW555_003641</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000837">
        <property type="protein sequence ID" value="KAH9630089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="40"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9630089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="649" mass="70904" checksum="70BA9931201800D6" modified="2021-09-29" version="1">MKQRVATDERPFKTGSTDETPSEEEPAAALVVPPDGGWGWVVMIASFCCNFMVDGVILSNGAILPAIRKEFNATEIEVAPINSLLAGFYLLLGPIASALANKYGFRTVTILGSVISAVGFATSYYATSPQYLYVSYGVIGGFGVCLIFMPAVLTVGFYFEKWRALATGIALCGSGVGVFVMSPITKSLVDTYGWRMTIFSQSGMMLLCILFGLTFKPIEPVHVVVEEEAATSEEEEAERNKLAAEKLKNMMKLENRLDSGIRMPHDMKFATKSSPHTWMGVSNNTRYPTAEEVFRGSSTVLNAQRRSSATAGTIKSNLGAKPAYATVSEKDEQEDSNSTPDKATQPLIGSVLRVMSHTDYSHQRRSTVDLVARPLYREDIFFGASLARLPQYTSRTSLGYHLAVTHVPSAEDEKEEKGRCQICPVAVRRALATLLDISLFKSVTFVILAISGFFTMTGFFVPFVYVQNRARENDVPAEAIEWLVSSIGVANIVGRLLCGLVSSMPKVSPLLVTNIALTMGGLATMLSNLCFDTYFQYGYCVIFGLSVACFAALRSIVVVEFLGLERLTNCFGLFLLFQGLGALIGSPIAGMLYDATKSYAISFYVSGAFILLSAVMCYPINRISKWEKKRAEENEKLKNTLPTSLVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNT2</accession>
    <name>A0A835GNT2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNT2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026112">
        <property type="entry name" value="AMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995">
        <property type="entry name" value="AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995:SF2">
        <property type="entry name" value="PROTEIN AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032457645" description="Protein amnionless" evidence="11">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="436" mass="48142" checksum="90E373CC71891E74" modified="2021-09-29" version="1">MSPIVALHCLVIFGTSLISATTVTWLPNSSFKLPDSFKERKLPCSKQTVVFPQTIVGSVEIASQTEVGGFILPEDGELILEGLLSFGADPADTNCTEGNAYYIDKTGSSWNTADVWSSPKFNKATPDSDRVPCFNDVVVFPKDAKITVTLPTLTQYVKEIRIGNDSFTNTAEFRDHVTLHMRDETQQFVLNDNSIVGLSIGRSMRCSQFGCACQNIPLEIDCSAKFCPKPQCVEPIRPLGFCCDICGGYLLFDADEGFDMKNFGELVEGIAGESGKNDIEYYIGFTPEIPFRRIQLVVVDKGEYEGSSAEIINSISYALHDHWVKGHKVAQISGSPLYKAGLGGKIFVSMFFAVILTLGALYVYYYKIPELRIPIVSRHMPAGIFSRFERRSDSVVSLTRRDSVISAASRSNTAFRNPLYNSKRGRVQVTEAAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPL8</accession>
    <name>A0A835GPL8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPL8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF36">
        <property type="entry name" value="EG:BACR7A4.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="549" mass="61022" checksum="BD37B4BD03FE12D8" modified="2021-09-29" version="1" fragment="single">VKTRSSSSPQDKRNTGAPNSCTADIVNESLINKPSRCVVQLSEPVTPMQEINKAYELSKFGRFHVKLLFVSFFGCIASILVTNTTSYLLPIAECDLNMNLKQKGLLTAMPYFGMFVSTVIAGLLIDTFGRIYFLRIGFGGIFLCTLFSASSQTYEMLAAAKLCEGILFATSLAAISSLTSEFCHTSVRDRVMLCQSSFAALTQILSPAMAWGILIQDWKYSFFGGRFVLNIWNFYLLIMSLWSLTAFLLYMILPESPKYLVTQKRYVEAKNILIQVYSENTGKPADTFPYKNIFEKEIKEAENDKSDGEVKVNFTKKILMSLKNMKPLLRRPLLGYLCLIAVMQFITLGTHNVIRLWFPQLSTIVEHYNLEGGQNLCGLLDEYTGSLEIKSLSNSTSDVCVPHVSGSETYINSIIIGLISLLPYFISGVIVNKVGKKVLLFVGGLISSGSLLGLKWSNSKTMMVAFFSSNIAVTQTMKSLTQVVLIEVFPTAMRTLSLSLVMLTARMGTLVGNVAFPILLAMGCSIPFYTMSALMGCKFYTFFINNFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPV2</accession>
    <name>A0A835GPV2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPV2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="292"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="105"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="380"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="634" mass="72306" checksum="03997C1D08240888" modified="2021-09-29" version="1">MNKMSRIPKMPPVTATKENKPGLPNRRPLARTLVSTLSDADKKDLLINHTKPARTGPSTVVPAQRLKRSATAPSAVAVPPPKVNKVEKKVTVAPKIAPYDYKARFNDLLGKHKNMKSEFDDLKEKHIEVSDSYEKTKDSVQSYVTERDRLKENLLKSLTDLREKTAEYDRMKVDYDIQKMENENLQRKTVLLDEITTSLKQKTAELDKVQSEFDALSRQHKSLQEETEALRVLTDSLKKISIQFDKLQLDYKEAQETIAKYKSESEILHNILAAMHKEQRDLRNTIQDLKGNIRVYCRIRPPLESEQSKPRYNLNVLDSCSIEVEKVELMNSVRKGKPQHGFTFDGIFTPHATQEDVFAEVSTMVQSALDGYNVCIFAYGQTGSGKTYTMEGGCGTEQYGIIPRAFNMIFTSMEDLKRMGWEVTIKASFLEIYNEIIYDLLNSSKDQVTHEIKMSDSKGTDVYVSNLKEEEVKNSHDFIRLMIFAQRNRQTAATLNNERSSRSHSVAQIKISAIHEKRKEKYTSNLNLVDLAGSESGKTTQRMEETKHINRSLSELSKVILSLQTNQSHIPYRNSKLTHLLMPSLGGNSKTLMLVNINQFDECFSETLNSLRFATQVNNCRVVKAKKNITMFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ44</accession>
    <name>A0A835GQ44_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001705</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9422711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="270" mass="31902" checksum="3CF3B959FC8DAEF2" modified="2021-09-29" version="1">MSSFLSVNLTVNYFTLSIKSQSKHQNNLRRFSAKMTNPFGVSAAEYNLIKQQAQRRSELRKEFLKQRTNPFKHASEAGYVFDPAMQKFLSMKVTQLEHFQANTRTSLFGICTIVIPMFAYGYILWKHRTTREDQIRKGELRYKDRMFKLQRANYRKEFLKLRTDPCKHSMQAGHVRNFSKGHLHLLDMISNRGVGGFLSGMFDKAIQHFLSMKNCQIEHFQVNFGTIRFALLSLAPMFTLGYIFWRTRTDREREIRCGRLKYKDRRNKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQI4</accession>
    <name>A0A835GQI4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQI4"/>
    <dbReference type="OrthoDB" id="7464803at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="51304" checksum="9F250F1FBE2740C1" modified="2021-09-29" version="1">MERAQAFMENFIGNWNGDFPNYPLTAEDLKKPHAVMGALLQVLDRLGIDTDVVLAPPPKEDRNENTIYYWDLLPVINMTRVINHLVSVMPQVEATISIVHFLQPTATTSHSILLLLFNLMVFNEEKMRNIAPYEEELFAKTGEVKALEEKKNRLLEMLNEQAEEKGKRAGRLEKLDHDIKMFEEELKQEKEIHDEEKLELEAIQKENKQTEMIIEQKKSHRDALMAEVARKRALRVYDADDIKAQAEQATQNLQELEEKLDSLRAILMQKENSLKNLQTIKPNLDSANNLLHEIMKLSDSLKDFENGDLDTDSKEGELDVLNTELGELQAQLSELQAARDEAARKRAESQAKRQQERTVAHSSLREAEEKDKKLRERSKKALQRTEEIKELTTKYENEKTAGIEQLATIKNNFCSELKSMEELLLKKVVEAEKKVEEKLKNRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQK6</accession>
    <name>A0A835GQK6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQK6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000002">
        <property type="entry name" value="glutathione hydrolase 1 proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="393"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="512" mass="56167" checksum="0092B96616244D32" modified="2021-09-29" version="1">MVQKIFNLAPYYSTCGNTICPVYGETTTNPIYGVTGYSDKRTHQRPYYYVTGSLLGGSIFSCSHYAVFFSTTWSSGPLSIGVPGELRGMWAAHKRWGKLPWETLVAPSLDLCRNGFAMSKVMYDGLESAPYIKNDPHLRKMYFNTAKGQFHKPGTMVKPSEALCNTYQRIAENGGDDLYNGTLAADFLDDLERVGSIITAEDLRQYEAKITEPIAVPLSNGDTFYSPPPPSSGAILVNILNILSGYNFTASSINTTEDKILTYHRIIEAFKYAYATRTKLGDSDFLDLSELIRNVTTPEYGTEVRLRINDTATSNDTATYGADTYNQPDAGTAHISIIAGNGDAVYGAGFSTLKTGIVMNNVMDDFSSPGITNYFGLKPSPANFIAPHKRPMSSMSPSIIVDRNGNAKLVIGASGGTKITTAVALVTIRKLWFDQSIKEAVDEARIHHQITPMHVEYEFGVTEDIVKGLRAKGHGMVRYRSRGSIICALYRNRTAIYANADFRKGGDVAGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQL1</accession>
    <name>A0A835GQL1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF174">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="43118" checksum="825D9AA8DFE0FAA1" modified="2021-09-29" version="1">MRTECTLGGVRAACGAAAGIGMSMTQPAGPAPAAANLLLLASNGPASTLTLFKSGPREAKIRPLAPLMLPTPSYDSNAGSPASSPSTPCSSSSFSIDKTDNHDTFGFSADAADMRKEDERMKTFEKWPVSFLTGEQLARNGFYYLGRGDEVRCAFCKVEIMRWVEGDDPAKDHQRWAPQCPFVRKLNGSASSDTSSSGQDECGARAAPSGTSPPRMAGPVHPRYASEAARLRSFKDWPRCMRQKPEELAEAGFFYTGQGDKTKCFYCDGGLKDWENHDVPWEQHARWFDRCAYVQLVKGREYVQKVISEACELSASEAERDVAPSRTATEPSAPTESPENSVDDSKLCKICYAEERNVCFVPCGHVVACAKCALAADKCPMCRRTFQNAVRLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQV5</accession>
    <name>A0A835GQV5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQV5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="842" mass="95613" checksum="BA6ED2B17D2F2B60" modified="2021-09-29" version="1">MAKSFDRSLQMHSTQFTPLKNRKNRQLLAREDTLNLSPILNETSIFKNLNDTSLRQVLDESSIIVNPGVSAEGLSEAFFEIIQASRPSDVLDTLARLAQVCCDSLELVEPWNRYNAQNYWLAEEANTWKLLHCLYADSITEHPESLDSLITETTLSQQTLVNALFRSDSELRLLQLLVDWLEATAAYQEEATKTSAPIISNNIHWGNTLHQLLLGNSLFNTEKSKSMVTCMDPDAPRRQKKIVHSEDQKDDNDLCKRIFTEVRCGKFKDAVSLCINAGQAWRGAVLQGWILLHYLPQEEPNSALEISGNPSRDLWKWCSLGLANNTAENIHYRATVGVLCGHLASTLPACQGSWEDLLWAHLRAQIEARVDKFLHEHHATVDASTTPSDVLELLQSELQVDEMTLQQIFNAVKALMDGKKESLYQTCQRHLMLGHVRAIMQDSLQWIDSCDDRFIRFLAHLILILRQMGKDPQHDIGDKILEKYVTELVSKLIDGSVECPELIAYYTSTVPVTRQIALYAELMDHVHKSEYREGVVKAGLNAGIDVGASARVAIKKAITDIQQGYGNLDLTFTQTTAVEKDKTLIQKVISSLEWLSLISNQVEEALWLSNAMIRTFIFIGNTDAALACVVNVNKMFPDFLNKIPTSSAELREHLCLKAYLEALEGFATWYRHFISGQPKDVEPLAPDASFSDKVHHEQRCAQVEQQKSRWLNAVQHQAKHTKDLLYNVLLFPGGWLQDENDSTTSEKFSDDEKQERTKQLETLRRLCLPEIVILILKILQSTDDIENHKEALKLCDLIAAENRCLYQVFTKSKMMEFLDRIKESSLILIEKGRDMFGYEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRG3</accession>
    <name>A0A835GRG3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein inscuteable homologue C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRG3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.10">
        <property type="entry name" value="Inscuteable LGN-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038205">
        <property type="entry name" value="INSC_LBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="2">
        <location>
            <begin position="869"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1168" mass="132187" checksum="048DCAAFC2BB209D" modified="2021-09-29" version="1">MLGMSNFQRTRSKVWWGDSPPNIGSPVAQPEWNRNNRARDDPDWEPQLPHWIANQPDEPQNNSADDIAQPIQMNQWPLRHGSPGSHKSQDSGFSDSDSSPPPSQYYQAPETTDNNKSSSSSDSNNNQDVTVKQAPGYQKTSPSRDANNVMLPDNVSCGMPTPKPRLRSSSVIQTPYDLQKYCEIHQDEEHMELLKDKDTENVSRIEKKSPSPKNINKDKVKVENKIDIKVTPPSNVSNKENNITTKSAIQKDTKEVPAKNINVISPSKKYPAKKSFISSTDSDSTKVIKVAKVKDLETSKNKSDDSLEYLKLEDDNEIAVNNQPRVRTPISNVSYVPTERTSTSRAEYTRSLSNEDATPITTTPKFQRNRLNKSLNFEAQRLDQQILDIQEGYHSLGYIDEEPNNDMMYENEQIHKPTKAILGKNIMDSLHLKPTKKPGPKAKQRMATKTDKTKDLFRIFPKKEKPGVVDDYAGGYLKGSRVPVLGLPRVKEQDSWVIVGHPEEMLIPHYNERLVGEQSDVTVKAAEKKENVEDFLKNGRVTPPPQFQDKQKAPYETEPKTNKNLTHDSKREKLKGELDFVDVQLNLACTSTPKMLAPHEFMDVPKSDRKSARKLNIQDEFNSENYPSRLVLNNQNEILYRERSIDQTCLERLCDRKPEPVQYWLCDLIGSCENECMTTLQSKPLGAEMKAMVSASSATITGNIKKVQTHGQIIVYQYSDVLRQIESGKSSEEQICLLIANINEFVLAHSITLNTKPPGETPERWDKIKKSLQLYLQKLIDVGEDVKVELNESVPEWTLVCKHLDTLIEIFLETTKAVLVQQMKTLVSIIEEPPSDMILKSTLTSIGHLAMLSDTTEGSLHEKCSKIMKNITELPFVDCAGGGIEIISDILSDRKNPEPQMREAITVLTQITAPWLRGHYDLTQMHLYLNNIVEHITGILSRTECCQLLLLCTACLVNLVRELELEKKDDDVTTKSDIVEVITKHRTVERLLDAVKRRGPNISVFLQTHIIFSLLHQEQTASLLASLSRIPRCMLLLSRVTSVCVALVCFARFSPGACARTAELRAQARLHCHAAEAISRLTVMPDVAYQIVQLEGVPLLTKLVRLQRTRPPLDTNPDQTLIHCLKALRTIYKHHPNTFDDEQDINDMIRPHLMESLMLFSAKKESYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRJ7</accession>
    <name>A0A835GRJ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_001374</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000344">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000345">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000306">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000382">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000124">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF31">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1728"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="155"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="272"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="375"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="492"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="603"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="717"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="829"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="953"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1057"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1175"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1281"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1389"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1506"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1767"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1788"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9423070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1884" mass="210096" checksum="EAF323A01C45C99A" modified="2021-09-29" version="1">MQARVTSHPPRVRLKPAQYKCITGFWLLLTILEVVVANRPPRFLIDGQSEIVVRLKEGPDTPVGSLIYRLRGIDPDGDTLQFGIRDQLGSDILRLEAISSNEANIYLVKELDREVRDEYSFVLTLTDGRLGDGNYITQSFLLLVEDVNDNEPIFKPYPSAITVKEDASPGILATVEATDQDEGAYGQVLYHLQELDGDVQSFAIQTVNGKGVIRLTNRLDYERKSLYQLRVLAVDRANQGRVNTGTAAILVKVQDVEDQPPEFVVASPVTRISEDAPIGTSVLQVRAIDGDRGINNRISYSIISGGEEHFDIDSSSGVVYTVNQLDREDPNNSNGAYILEILATEESRTISPMPSATTEVTVIVTDVNDETPRFRNDRYVGEVLENAQQNTPITFLQDAIPEVFDYDQGKNGTFELYLTGDHGVFDVTPFKGINEASFLIRVNDASFLDYEKVTVMNFSLVAKEIVTKDPKMSIVPIVVHIKDENDNFPEFTESLYTVSIPENCGVGTTVAWVQALDQDSDNYGTRGIRYTSLGGSIANLLNLNPISGVITVKQAGGDSFDRELISRHYLTVEARDDLGKGNRNTAQLIINIEDVNDNAPMFLANKYEARLLENEKEFENPLVLEARDLDLNGTKNSHIEYSIVGGEYKDNFTIDPNLGIITPLGGLDFEQIPGDNSNLRPIHLTVRARDFGEPSLSSTVPVTIYVQDVNDHAPLFQQMMYKRSIPEDMPGGTSVLEVKARDADGSSPNNRVVYRIQRGASDKFVIESRTGVVSVANGSTLDPDKTTPKSNRYTLTVVALDGGIGDQQLSAAVLVNITIVDVNNKPPVLVEPGTIVVRENTQVGTQIYRALAHDPDDQPVLRYAIDKANSVARDEDGIPISLTEYDFLALWDLNAVDGTLKVVRLLDREKLEIVKLVITVEDMAAIDDGPRQTASATLTIVVDDENDNNPVFRKPMYKTSITENSKNGANIATVIADDADKNKSMNYFLEGREDLLNLVHMDSKTGEVVVASKIDHELYPWINLTVKGVDSGVPPRYSVVDLFIQVLDENDNNPIFESSAFEYRVLEDVEPGTTIANILARDADSGEFGKITYLLDRMSTQGKFLINADTGALTVSDWLDRETQATYNLVIEAWDNYQFGYLSGESRNAFKQIVVHIEDVNDNPPILHVPSECTTITEFHNYREPIVSVSATDADDNSAPNGRVQFHLVGGKGHELFRFEQVGGDANTGRLFARQSLKDRFGNYTLVVEARDLGIPPNVVRGELRLCVTDYNDHAPVFVHPPQNVTIKVPENATIGTTVVEVRAIDADIGPNGAVRYRVRQDAAGAWRAFTVHATSGALRTTQPLDRDKQTTYQLRIEAYDLGLPTPLSSDLDLTIYVQNVDNYRPRFPNKHIHINFTENAPNNGIYLPSVIERDEIDRGDEPLLPVCYYIVDGDADNVFDLHRSTHRLTTKKPLDREQKSEYFLTILASEDCVTQPKYDEEVDGISTLKVHVIVNDVNDNAPKFVSKIFTGGITTEADFGIEFMHVKAIDLDEGENAKISYYLIGDVKETLAEGLENLAVSLFLVNVDTGAISLNFDPQKGMKGYFDFKVLANDTGGLQDEAHVFIYLLREDQRVRFVLRSHPSEIRDKIHVFRERLARVTESVVNVDDLRVHENKDGSVDNTKTDLYLHLVNGEDHSVLEVEQVLKLVDKNIEQLDDLFKEFNVLDTQPAEYQPLTAETLSSNQTVFWLVWTTLFLAVLLVLTVMMCLSQRADYVRRLKAATATAYSSPTPGDSDMTIRSSGGRVPNTNKHSTKGSNPIWLHAYENDWYKSEDQLSRSERDSLDENAVDQDLSNEKPYFITTGAFPSLESNETEPQTNQAKYDFYQQLEQMKNAKNMETTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRN7</accession>
    <name>A0A835GRN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein giant-lens</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRN7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021633">
        <property type="entry name" value="Argos"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11581">
        <property type="entry name" value="Argos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30622" checksum="DD893C22D19B9E78" modified="2021-09-29" version="1">MRFKTVSSSPASPRRKNVPTANRLPNGTSSGRKYDRWSFWRQKNKRTRAHVHIGSEEDLPDCRPRQVCSKVDLYDATQPWIERKCRCLGHRPCSSDLTADDNHTLSDKTTLYKTCEPVKRLPKCKYFKDAAWIIYSFPDSNATQQIVNCHCPKFSVTYLLKKLPYTTPSGEQGNQYQFACSPQSRLRCSRKEPCKLFSARRRHEQIDEVNANTICQCPRGHTCPRHHTETGVLAGITYAAEDIRTYHGYCMPEPPPDAYRFVGDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS17</accession>
    <name>A0A835GS17_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemosensory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_008954</name>
        <name evidence="2" type="ORF">HW555_000162</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000188">
        <property type="protein sequence ID" value="KAH9642544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS17"/>
    <dbReference type="OrthoDB" id="6625994at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032443807" description="Chemosensory protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9642544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14987" checksum="E386D91EB4C1E997" modified="2021-09-29" version="1">MKSMIVLCVLSVAALVVARPDDSHYTDRYDNVDLDEILSNRRLLVPYVKCILDQGKCAPDAKELKEHIREALENECGKCTETQKKGTRRVIEYLINNEEEYWNELTAKYDPERKYTTKYEKELKKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSP0</accession>
    <name>A0A835GSP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine-rich storage protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the hemocyanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032597627" description="Methionine-rich storage protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="163"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="448"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="89056" checksum="98E51CBA85D14C43" modified="2021-09-29" version="1">MRVLLVLAAVALAAANVVKDDTNVFIGKDNMVNFDIKMKELCIMKLLNHILQPTMYDDVREVAREWTIEDNVDKYLKAEVVRDFIDTFKMGMLPRGEIFVHTNELHMIQAVKVFKILYFAKDFDVFMRTACWLRERINGGMFVYALTACVFHRADCRGITLPAPYEIYPYFFVDSHVINKAFMMKMTKAANDPILMNYYGIKVTDKNLVVIDWRKGVRRSLSQNDRISYFTEDIDLNTYLYYLHMSYPYWMKHDMYAVNKERRGEIMSYATMQLLARMRLERLSHEMCDIKPIMWNEPLKTGYWPKIRLHTGDEMPVRSNNMILVTKENLKWKRMLDDVERKLRDGILNGKIERRDGTVISLKKPEDIEYLARMVLGGMGLVSDDAKFMHMMHLMKRLLSYNVYNFDKYTYVPTALDMYTTCLRDPVFWRLMKRVTDVFVLFKKMLPKYTREDFDFPGVKIDRFTTDKLVTFMDEYDLDITNALYLDDTEMKKKRPDMLMVARMRRLNHHPFKVTVDVTSDKTVDAVVRIFIGPKYDCLGRLMSVNDKRLDMVEIDTFKYKLETGKNTIVRNSVEMHGVIEQRPWTRRILNNMRDTVGMISKTVDVESWWYKTRVGYPHRLLLPLGRLGGFPLQMYVIITPVRTNLLLPTVDMNLMKERRTCRWSVCFDTMPLGFPFDRKIDMTKFFTQNMKFADVMVYRKDLGLSNNIKDVDMSDMMMKKDDLTYLDTDMLTRWSYKDVMMMSKDDMMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT33</accession>
    <name>A0A835GT33_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT33"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17240" checksum="3042CEE9B88EBF5D" modified="2021-09-29" version="1">MTDFEKELKKNPNTSSDTTQGITAEFSAFRSFAMQALTMLQQQVNFLAQTIDTMEMRGRRKILLLHGIPETKEEDTAGVVVRVVKEHLKLDLEVPDIKRCHRMGRSTQKPRPILFKLHNTALRDGIWFGKTSLKGTGITISEFLTKTRHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTH3</accession>
    <name>A0A835GTH3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTH3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032765026" evidence="1">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="132" mass="14815" checksum="A7173DAD314D2D10" modified="2021-09-29" version="1">MKTFAVFAVVIVSCFAQRSPYAGRLPIGYPYIEPSTAAPTTAGSGLGNRFGDEVGTSTTIRLPLEALGDVELVRRLSKLPVEHQPFWLLNWKALEENRKRPQTYPQRGNGFIDDTFNSNSLLLNNNQRFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU72</accession>
    <name>A0A835GU72_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU72"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="288"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="375" mass="43269" checksum="152A670EC5C91B1D" modified="2021-09-29" version="1">MCSESLPKEFEKTTEVLPFPKYGLSSMEEFRKAEEEVHHHEWLKKAGLTSEEIKLYQENEAGLLDQRKKIESGVLKDKLEEIYNKINNTHNETKSHTVTSQTEQPSTSSTPENLIERLQQKPITFYPEGHPMNELKQLEGNLFGHMKNDIMPLTKRRKLLRRLQRKKERLQHDNPFNIAAIPSTSRVDRPGSLWDMREMPRLIPHTITSKDQEANAMGPHFRAMYTVRNNKILRLEPVQREQEEYRAVDIVMPINDAEANLLEGTKMTVDDIRKIDRFKDWTPGSPSKVLYLKNIAPTVSHEQLSLLFNQFVLANGGPVDVRLMTGRMRGQAFVSFQSEEIAIQALEEVHGTILSGRPVIAEFGRNTNSIQDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVP5</accession>
    <name>A0A835GVP5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVP5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="46"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="396"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="520"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9424208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="799" mass="89769" checksum="823CA3E51C7FCB34" modified="2021-09-29" version="1">MEMESLDPAQAFMAKITERFKPVHDITARGTSSVQQFYHGSTAFMTGGSGFLGKQLIEKLLRATKISKIYVLLRCKKGKTVQQRLEETLKDPLYDKLREQQPDFVDKVVAVSGDVSELKLGLSEKDWNTIADEVDLIFHLAATTRFDETLKTATFINVRGTREIVTLGKACKKLRSFVYVSTAFSHARDEYVYGEVLEKFSPSPVSPETMIGIAETMEEERIIDITTKLIKSWPNTYTFTKAIAEDIVNTMGKDLPICVVRPAVVTCTIREPAPGWVDKSCIYGASGYMYAVGLGVSHVAYGNHSNQLDLVPVDYVNNTILAAAWETARLKSSAPEENEIKIYVVSSRSRNPVTWSDLQIIMAKEGRKFPTPQAVGYTFAWCTSNQLVFWIYSWLLHLIPAYTIDTISVLFGNKRRFGKLAQKLSKMKVALSHFMKHYWKFEDQNTVTLLSSLSEDDREIFDFDVTKIQCIIRFAMATETLDPAQAFITKIANRLKPVQEITARGTSNVQQFYCGATVFVTGGSGFLGKHLIEKLFRATKVSKIYVLLRCKKGKSVNQRLFEMLKDPPEFVDKIVAVSGDVSELKLGLSGKDWNTIADEVDIILHLAATTRFDETLKTATFINVRGTRELLNIGKACKKLRSFVYVSTAFTHARADRVDQTISEKFYPSPISPETMIGIAETMDEGKIYNITSSLIKNWPNTYTYTKAVAESLVEAMGKDLPICVVRPAIGALHATYVKEDNIMELVPVDYVNNAILVAAWETAKTKTSVPEENEIKIYTVTSSSRNALYWREKICLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXZ3</accession>
    <name>A0A835KXZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_014128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000864">
        <property type="protein sequence ID" value="KAF9404872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051794">
        <property type="entry name" value="PG_Endopeptidase_C40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359:SF3">
        <property type="entry name" value="NLP_P60 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359">
        <property type="entry name" value="PEPTIDOGLYCAN DL-ENDOPEPTIDASE CWLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032548252" description="NlpC/P60 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="7">
        <location>
            <begin position="170"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9404872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="287" mass="31468" checksum="5D820A05447C2B18" modified="2021-09-29" version="1">MKRIRFNFFLLLADQVFATSDETQEKIITESTEKLSQLKDTKQKYSEQKNEKIITLTDLNKEIQDIQQNLEQLEKFNLAGKVNDPSKENTSTTESLFTSLPVVLSTSEQVSNPITDIKEKLTDLKQQHRSLLEETTEISTNQELLQQEEIQLAEKITQAQQQKSELIKQIDSRSAVVAAAKAHLGKPYVYGAAGPDSFDCSGLVQVAFAAIGHPVGRTTINQETAGTTISVAEAQAGDLVFWGSHGGTYHVGISTGDGSYIHAPVPGDVVQIATVASYSPDFAVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY75</accession>
    <name>A0A835KY75_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_013370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000632">
        <property type="protein sequence ID" value="KAF9406159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="31"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="371"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9406159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="505" mass="58025" checksum="11E0A9729205BDC4" modified="2021-09-29" version="1">MAATQLISASDVIAGDFNKIENETKYCPQCFLGKILVEKLLRCCPGVENLYLLVRQKRGKDIYTRMEEIFDDPVFSRLKEEVPKFRHKVVVVPADCEAAGLGLTLTDRQMLTEKVNIIFHSAATVKFDEHLRAALVTNVMAPLHLLRLARDVKKLDVLMHISTAYSNSHLPMIEERFYPCEADCEQLHQMVDKLTDDQLNIMLPKILGPWPNTYTFTKALAEKELRASAGGMPIGIFRPAIVISTAKEPLKGWLDNMYGPTGVAVGSATGILRTVQCDKMVSADIVPVDSVVNCLMVAACSVHNAYRRSSPPLEPPIFNYVSSVENRITWGDFLSKNMAWIHHYPFSDAVWFISVRLTKSAAVNKIYMFFLHLIPATLVDGLAVCLGRKPKMLKVYRKIHKFSSVLSYFCTREIKFCNSRTRELWEKTSEADKKIYPFSMSDLNWEEYFRDYLAGIRRYLFKESDDTLPQARIKWKRLYYLHQITRFIFFILAVYALWWILSLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYS4</accession>
    <name>A0A835KYS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYS4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="49539" checksum="BA8061525D9C17A8" modified="2021-09-29" version="1" fragment="single">WQIVTSQRGKRVLLRAGHRYHEKRRNKDGSCKKCKAKLIIANNNTITRDDKHDCEPDFASNELEIQFNKCCEQIKSDYTISIPRAYRETVAGPVDSGIDFIKKIPTLENIKHKLHRKRNKSLGVQKICFNSIKEIIVPERYQHFLLADYSNGPSRIIIFANRDCKKILTNPNLTILCDGTFKFCLKHNDTYNNIIPIIYALLPNKNKNTYITMFKLIKSQIPQFSPQLFILDFEQAAMSAIKHVFPKTKINGCYFHFAQSLWRKADELNITTSKLARKHVKRCTVMAHLPREAIDNAWLYIMAQCPTNKNVVLFNNYFVQTWLNDKSFFADKWCSNHLHRTTNMIENWHSILNKKISSKPKNIAHFLTILEKENNYYEVLYTNGTSIRKKLPETQEIDQHISQTIEEFITGDINIDLCIERLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L050</accession>
    <name>A0A835L050_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000387">
        <property type="protein sequence ID" value="KAF9408379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L050"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="674" mass="77587" checksum="BB53BF4EF27A7E63" modified="2021-09-29" version="1">MKKPKQPEPKTKPGPDLTEFINRIYAEPYSMTSTVFDTFCETQVTYNSHHPLSLGTQSLFNEFKISPHQNTVNPTEIDLTCNELMLPLDFSPLDEEIPLNTEGTCENSPLDFDSDDSVIDKDYCPSDSSESHMSDVPESGRKTKKKTMKTNNGNYCSILPVHDEDRMFFNLKSRRRNSIGTCKETTPERLCHRKRCKSVDGNYCSTLSDILQLPRKRMKHNTPLQHRRLDAKNKNYPPFHSISIILGAMKSALRNEQHAFVEAHTYVAVPKRKITNGTRKDVCKIYFLTTLGYLKNNDRILHPTFTDSSIDKRGKHQKTPAFDRDLLNQHVESFNPLEPHYRREHAPLRRYLPSDVNITQMHNNFETSHDATVQILKNCTVCVDWSYHRQRYTKARDLYQKHKDETQNNTQIFYSSDLEKVIMLPRLEMFKAATFCLRLSAYNQTFAPLGKITAQLKPLTVIWHDGIAGRKQEDIMSAFYNLKNSQNKNWLLHAMLTHMINSEDIATQIITLYYFEPGHTFMSCDQVHHQVELVMKKKAFATLDGNFVAELPRRLGEPLAGKRDDAERCFCFRYLSTGMNFCQTSCACVVTASYPLNVARCIKIHVMRRCRSYADGRSVRGRPSRRERVTVRAERGIVRDGTTDLRRSVPVICILYAITCIGVPPRKFGDGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0B7</accession>
    <name>A0A835L0B7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="17781" checksum="9D93C0842EFE7BAC" modified="2021-09-29" version="1">MAGFRVDRDKDVPPTSGVRTGFTGVVDTTDPLLTEQKYAENPQKGWIWDCFEDKESSARLRVTLMNRDYSYLRPNEILITHIKRLLDRMTDLQVTVPPRIRHLYALLKKDFKQAPEYGQMHHLLDFNKTLPPKYNANKLNRVFTTAITPYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2P0</accession>
    <name>A0A835L2P0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000253">
        <property type="protein sequence ID" value="KAF9410652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2P0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="99"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="45702" checksum="CB02EA7E32FD9FD0" modified="2021-09-29" version="1" fragment="single">RETITAEILRADVNDEHKVDFKVQNQVVHQLSVYVTDGTSNYIVKHVVWLGTEADIVACDAGQVVGVCVCGRGRGVRGARVPTRRVLQYGMPRQRDAMVMVPPHARDQFLTSLDTEGVSHYVHIEDVAQALEKHDADISSWRSSRAPRMIFQDYQRYAEWVTTPVALYSVYRLVENLRPQDRDLLHDIDWIILPVVNPDGYEYSHTTDRLWRKTRSIDESVSTTCVGVDGNRNFDVRHGQGTPADPCQNTYAGPRPFSEPETGYVRDILAEHKDRVQIFMDIHSHGNYVLFAYGDTTLPPNALQIFLVGAAMGAAMDAIKLPQAGFYRVGNSASVLYPSSGSAQDYGQVAGAATSYTLELPGYGYGFLVPPHYMDHVNEETWQGIAVTARYSRALYRQRYNAASNTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L351</accession>
    <name>A0A835L351_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein odr-4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODR-4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000177">
        <property type="protein sequence ID" value="KAF9412830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L351"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029454">
        <property type="entry name" value="ODR-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966:SF1">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14778">
        <property type="entry name" value="ODR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52139" checksum="1C0082D331455577" modified="2021-09-29" version="1">MVRTVYSPEYCLQYLEQYASKEIFVIGLILGQSTAARENVIHLARTPDEKSSESASEASYVSDKVETKTLLNVSEAWVADHAKHVTRMLPGGMFVQGIFITSDEDIFEEPNSFSKVKSIVNHIYKAMNTNQYMFGNCPNSNERFMLHMSTSTKVLTCKSIEVGAPAKSTVIKPVEWKFLPKAQQWQRLDCYYEFDDVYPVIVKKSGISVKQQFQQILESAHKTIESSIMFIDGELKDNSEVLEQLFKKKKPKTNSKSAQQELPKSMNVSLFVPFENSLPETVEYLECDGSIHFSGVVSSSVFMYPKATVSETIAAVKQDIIRSLASRFTMHCDALIDDNLLPEEKVCFNEPPRRVLVPVGALYLCDYLFPGEAPAEALLSVRELLDLKITEADVICDVETPADTSEFDALDRDASSEELLATPQEASQFMYITGICFAMFVLIVSIIIHYYDGIVKVLSKVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3D2</accession>
    <name>A0A835L3D2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_003481</name>
        <name evidence="9" type="ORF">HW555_007713</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000488">
        <property type="protein sequence ID" value="KAH9636663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3D2"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000004">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9636663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="159" mass="18533" checksum="DD856768CB244BB8" modified="2021-09-29" version="1">MADDIVFELLHSEIINYALDQSKDNNNDKKEVDLSVVEYIGFAAGYKIMERLTREWPRFKDELDTMKFICTDFWTCIYKKQIDNLRTNHQGVYVLQDNAFRFLTNFSNGHQYLEFAPRYVAYTCGLIRGGLANLCINSVVTAEVQSMPSCKFHIHVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3V2</accession>
    <name>A0A835L3V2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_017107</name>
        <name evidence="10" type="ORF">HW555_012184</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000418">
        <property type="protein sequence ID" value="KAF9407971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000221">
        <property type="protein sequence ID" value="KAH9641583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3V2"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF14">
        <property type="entry name" value="FI16615P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9407971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9641583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="13045" checksum="82F0B9FD510BEFD0" modified="2021-09-29" version="1">MYPANPPPYPGQEPTPVQVNVIHVQPVAGHYVTASGDTVLIGQPVGTEPTLVVCQSCRHQIITTTEMRPTARTHLWAFCLFIIGCWPCMCIPYCTPSCMNIDHYCPNCRGYIGKYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L439</accession>
    <name>A0A835L439_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L439"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="592" mass="68756" checksum="71CA74E609B1904B" modified="2021-09-29" version="1">MSSFLCFICRNTVNSDTSEDTREKYREIVGMNLCPDSHLCYICKHLVDKLWLFKSLCLKRSLEYPVLFSAKGTVNLQRNAIKPIILCTEEICLRTDGNQFYIENKDQSINSHDYIKLEDDRDDHRHDDYFSQTHVEDEEKQTNDDLETNDCQIYDNDCQIYDNDCQMYNNDCQIYNNDGDLDNNVDSGENEEDFTSNHENNDLESNIDAGNIAAPSEFYAEEKNECINEIRNENSAQEGEDDAETKSDKTSSKTKTKAFEKILLPFEEQKADLEQQRRSKKYLESEFKCFNCALGFLFKDTYQTHMMRHEESNGEYRCDVCSLRFATGAVLRSHAMLHSVRYRCLVCSEWVRARQTTTHAKYCHRTATSATCHLCGRLFQDSSGLHQHLKRFHMTRTGNRTYSCSVCGKNYNNQAAVRTHMIKHIHRKFSCDQCSSVFSSPYTLSQHKKKHLRTEESREFFCDTCGVSYSTRKSLLAHQRQSLNHQTRSYDCPICNRACPNEKSLASHISAVHSSTKNFCCSTCTARYTNRKSLIRHIKSHTNPTPIKLAYCHICGNSFKGKSKLNRHLREVCEKDKLEEELSSYYDQQHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L468</accession>
    <name>A0A835L468_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytosolic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytosolic galactosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytosolic glucosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytosolic glycosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_007674</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-galactosyl-(1&lt;-&gt;1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:59292"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-galactosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:43908"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:57934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:43909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59284"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:59285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59288"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:83992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:59289"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000134">
        <property type="protein sequence ID" value="KAF9414420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L468"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9414420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1011" mass="116113" checksum="38D8CB5334D81D29" modified="2021-09-29" version="1" fragment="single">MAAVAIQGANVRQQRRFPDDFLFGAATAAYQIEGALPNNFVNNVLLFPGKGENIWDHMIHTNPTVIRDVTNGDVAADSYHNYKRDVEMMRELGLDAYRFSLSWPRILPTGMANEVNPAGITFYNNYINEMLKYNITPMVTLYHWDLPQKLQDLGGFANPLFSDWFEDYARVVFENFGDRVKMFITFNEPREICYQGYGGDLNAPILNSTAVGTYLCAKHLLIGHAKAYHLYNKEFKPTQGGQCGITISVNWFGPATDSAEDQMAAEIKRQAEWGIYAHPIFSSEGGFPKEFSERVAEKSAKQGYRRSRLPEFTEEEKDFVRGSSDFFGVNHYTARLISATLYKEAVPVPSLLDDMDVGHYAPDDWATSASSWLVLAPNSIFNALKHLKERYNNPNFYVTENGWSTYYEAGLIDEDRITYYRASMESLLNCLDDGINLKGYMAWSLMDNFEWMQGYVERFGLYEVDISDPARTRTPRKSAFVILVGSDGWTDTRKRRFPQNFLFGAATSAYQVEGAWNEDAKGESIWDRFAHEHPEKIADGRNGDVASDSYHLWKRDVEMLRELGVDFYRFSISWPRVMPTGFPSKINEAGFKYYDDLIDELLKYDIQPMVTLYHFDLPQDLDDLGGWTNPLSVSWFEDYARIVFKRYAEKVKFWITINQPNTICMEGYGSDLMAPGLNARDVGAYECVKNVLLAHAKAYRLYEKEFKKEHEGNVGFAVAVNWFESLDHNNTVNKEAAERARAFEFGIYLHPIWSKEGDFPPIVRTIVDKKSQEQGFKTSRLPKLSNEEIKLLKGSADFLGMNHYTTFLVQHSKEKFEGPSVEDDRNTIYSQGPEWISGKSSWLKSAPYGLYKALIHLNLNYDYLPIIITEHGWSTNKGLGDQSRVDNMRGYLGALLLAMEDGTQVKGYTVWSLMDNVEWTAGTSERFGLYEVDFESETKERTARLSALVYKHIIETRDVEDGWSPSSLKIEITKKSYEKNYNYKASYINKLIFTEIQHYFCLPIHFESYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L487</accession>
    <name>A0A835L487_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">trypsin</fullName>
            <ecNumber evidence="10">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_011810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000377">
        <property type="protein sequence ID" value="KAF9408542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L487"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032895535" description="trypsin" evidence="12">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="109"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9408542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="354" mass="38773" checksum="B7482B6817D7B7E2" modified="2021-09-29" version="1">MWKSLTVLNIILLNLVISEDVGETCTSNQALEGVCMEVSKCEAAIIAISNKKFHEFKRCGFSGFEEVVCCPRTTTKFGGDETRTKAKRIADRECQKIKDSSIPPLDLHILGGETASLGEFPHMVALGYDRGNGYEFDCGGSVLSHNYILSAAHCVDTLDRIQPSIIRGGVIEIGGREFNPDTDDRIAEIILNPRYTRKEKYHDLALLRLETPLQFSSNLNAVCLETSEQDPQVPLTITGWGKTSNTRDTRSNLLLKTNVTTVGRSKCSESYINWRKLPSGISPDQMCAGDPEGIRDTCQGDSGGPLQSSGSDGLSRLVGVTSFGRGCGSSVPGVYTRVSRYLDWIESIVWPNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4P0</accession>
    <name>A0A835L4P0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4P0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="38035" checksum="295D45CB3D8FE230" modified="2021-09-29" version="1">MFTIKRVDDGSDWSALSRRVYHQSTRSPLPFVVQHAKCNPEICVEETKPEMPSAPLTSEYMEGFLQHMERNELSRRKHALKHRQSILKKYFLMVEPTGFLLKYVYGIQGYIFCTASAYHTKMSSRQPFREDSDTADTDGRLSSECSPLPQRRGGILKGGRLWKSLDTDKDINEQNDDQRSTTTASDEDGSITPRSVRFLERPKDSEEDHPKKEPETVHTQTENSEMTTQQKEYNSTSGTHRLETPLILTINAPKANSAVQQLFNSGRPPPPAIEPQLVTSETLRAWDAGVRPKTEEAAVRRVAERNALRCSLLRSEARKKQQPKIRGNFNMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5K0</accession>
    <name>A0A835L5K0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5K0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF106">
        <property type="entry name" value="T-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9415007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="43623" checksum="89C6262D16691688" modified="2021-09-29" version="1">MAASHILSAVEPTVGGGSSRSGREREVNVALDDRELWVRFQTLTNEMIVTKNGRPKLRRMFPVVKVTASGLDPTAMYTVLLEFVQVDSHRWKYVNGEWVPGGKAEVPPSNAIYIHPESPNFGAHWMKEPISFAKVKLTNKTNGNGQKALAARCECATVSWLPLSSVRRIGGWFVTSQSLYGSSNAASRRPAPYPPRPPSRPRTLSPPSSYSNSERTTTATNGSGSYTWVSSSGYWNSTQGSSSPQPNTSPAPYRTPPHAYPAPLEYAPAPPTSTSAPTSAPAPLYPLQYEAPAQHHSPYYQHAYAPYAHHAIEDISYWPNSLNSYGYQPSEYVGSGEVAYGGEGMPFGSAGPSLEAAAAGEGRATPPGQEHPQSEREYKFSAEEERQSPCDEPALPPRSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5K6</accession>
    <name>A0A835L5K6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5K6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="628" mass="70912" checksum="E040521B2E06330E" modified="2021-09-29" version="1">MKCLPVGCHAYSQGAAGTAFTQLVTHFLASQCLITEQWPTDYSYGLSSGDTFDFIIVGAGTAGSLLANRLSEVEEWKILLIEAGGDPPMESIIPNYATATHRTRNAYQYYTEQEDNIHRGGLDRRAYWPRGKGLGGTSSINGHLHMRGSAGDYAPWHMSEDDGWDWPTLREYFKKSEKMVDPFILNNPELRKEHGTEGEFVVDQLNFTHGDIAERLTDAYKELGLTYLDDLNGPTQLGVGKLRGAIHKGRRVSSATAFLNTARERKNLKVMKYSFVKKLEIDAKNKTVKGVTLSLLYGDVETYFARKEVIVSAGAINTPKLLMMSGIGPKAHLKEMDIRLVTDLSVGKNLQDHVRIPIPVTVDTGAERRGEEFWQKAAAQYLIDQTGPLATNYDQPNINAFLSVTGDKTLPDVQIDHNYFLPNTSYIHSMCKDTFSFNDSICKQFVEFNKEKEMFIFFVALCRPHSRGEILIRGKNAMEHPKIFTRYLNDSRDMETFVKGIKKVMEIVKTPTFKNMKAEIKRIYFEGCDDFEFESDDYWECMARTVTYHVYHPVGTAMMGKSRESGAVVDSRLKVFGLKNLRVVDASVMPTIPSVNTNAPTMMIAERAADFIKEDYQRGTIENQRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Q7</accession>
    <name>A0A835L5Q7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5Q7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="429" mass="50131" checksum="7FDFAF0733B349B2" modified="2021-09-29" version="1">MIDEAITYKKMGFNRTKYEAKSNRKGVEKIIQRFYEDDNNSRCAAGKKECITRNKIKKQKRYLQDSLKTCTKRYAEFCKLRPFWIVVPKLTDRDTCACIAHENINLKLDALKIANVLKFSTYQTALMILCCDRYSEDCLARTCKNCSIKIIPYMEFDNSKKIEVKQWKQVKELIKDLKIKQNRYVTKYKKEINSFKPRDLITQLEEYDLPKLLQHNKISFINSLSEMDAIIHMDFSENYTTKCNKEIQSYHFGGSRTQISLHTVVVYTEDKTTFYCTLSLNFCFCDNVECSHYKLGTIIYQSNTKRLQVQDVFTDSEDDMPLASISQNAQEKSKISYSSGDYVLLKLILKRKEYRYAAVCSKYDDEDGELTVKFLKVSNDTGTEFQLNENDIADVPYEDILHKLPVPKVIVKGGTVCYKFKEPVNVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7K7</accession>
    <name>A0A835L7K7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7K7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1010" mass="116552" checksum="3D3EC2CA4319DBF0" modified="2021-09-29" version="1">MVQCGPHGRFEYCIDGIPGCVIGCHCHPGYYFDTDTKTCEPNVKLTQDIRQHYYGEHGPGSGAPSFIPSTETYPSATPNDRIGNKGNEILKDTDELGDWLYNQFFKTIESQVINNSNSTKPINNNKPPTRRSGGDSKPSVVSTKKIKTRRSFGRTRKRKHNMKMHGLRRKLLRITEDDSLRPKPPLPSFIFLPNMDTPYYPPIGLPPPPPMPMYPMVPVPPMGAPMYPFPGTVTNCDVNITTTTSEMTTLTTTVSTTTKITIPEKKSGVRRSKFERFKNRPVDDEEFMLRASEPGKQAKLKNTQRNKLMRKLRDKIKEKRKNIAPPTSEDESDLLVNLDDLPNVSDAFTSFKKRKINKEDDESQTPNLKDVDFKYLSELIHKVNQSAPRNKIYPSPPLPFDLKNGIKELQKLKAQPTRRNFDYFAQVPAPVGAEIASPYDQPRNLNKPSSDDAYYTNLGRQIASMIRNNEFKTDQPFNTDQHRQVPFRSVLNENNYSPGSLWERSVRSPLPQLSDIKPNTYLDESRTLKHSNEKNLLNLENEVESYVSTQPPLSLQELENILNAVEKAQDLMKDPLDSPKPTNSSLNVNILPEYLRGDHAFRKLYDMDNTDDFSPEEKTRHYFYMKKSPADTKYSNFSLNFPPEYHRGDNTYRSLFGSGIDDFLSPAEKAQYYFQVQKQDSPRYPKTSNINYTVTIPSDYVRGDNRQSFGTDNANILKPEKATNSFELQNTPEDEKPLNDRLNVHLLPRHPRGDIDNLYPIERAQFYNQLKNSLATPKPTNGSFHVLMVPKYTGDSHVYRRLYSADNQPLTHTPRPPNKFVEPKLITGNYHSLYPLKFEEARNPTNTSNKTIFQDIGRNHIPQSRDYWMSINDHVPNQLEREPKSPVKSEHIEQTNKPLQHDNKIQATNQVGQDPFVGVVVPTSLIHTNSPRTEYLQFLKIIPNLKQTSNQKREPMKQNNLLNYFSRNKYHYMFEKDSHPILAPFRRRISKNYDRPSYFHHNLHHYEYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9A9</accession>
    <name>A0A835L9A9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement component 1 Q subcomponent-binding protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9A9"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000005">
        <property type="entry name" value="Glycoprotein gC1qBP, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32399" checksum="7702FF2A7A48CDF8" modified="2021-09-29" version="1">MNGLGRTATRLIQNCVKNTTLTGALVNRAQAPVKRDFTRGIWHMSCSKRLDGSATTSTLLHNHSNTCSCGCGLKALHTKETEIEPPSSQLKPRPLGERELVEFLTEEIVAERKAQKVKVLPTELEGFVICGDGAEVVLSKKLKDELVRITFNVNHTVDSDDLEGEVQPEKQEFAEMRSRPQFEVDLVRGDTTLGFTCSFLQEPPPAAGGADEYNDVFGIDEVTIYKGEWNDKVYAVAGDVLDGYLYDLLMNLLEEKGISNEFVNKLSDFSTAYEHSAYIKLLESVSQFTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9Y7</accession>
    <name>A0A835L9Y7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-binding cassette sub-family F member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_000654</name>
        <name evidence="10" type="ORF">HW555_006537</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000599">
        <property type="protein sequence ID" value="KAH9634682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9Y7"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000467">
        <property type="entry name" value="ATP-binding cassette sub-family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="82"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="394"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9634682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="620" mass="70755" checksum="7135BAE7EDBD93D9" modified="2021-09-29" version="1">MPSDAKKRAQQKKKEQASNRNKKTVARVTNEENGSATNGNKEERELTAEEALCLKLEEEAKMNSEARSCTGSLAVHPRSRDIKIANFSITFYGSELLQDTLLELNCGRRYGLVGLNGCGKSSLLAVLGRREVTIPAHIDIFHLTREMPASDKTALQCVMEVDEERIQLEKLAEELAQCEDDDAQEQLMDVYDRLEDLSADTAEARAANILHGLGFTKEMQQKATKDFSGGWRMRIALARALYVKPHLLLLDEPTNHLDLDACVWLEEELKHYKRILVLISHSQDFLNGVCTNIIHMSKRRLKYYTGNYEAFVRTRMELLENQMKQYNWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVIDDKILNFYFPSCGKVPPPVIMVQNVSFRYTDSGPWIYKNLEFGIDLDTRLALVGPNGAGKSTLLKLLYGDLVPSTGMIRKNSHLRIGRYHQHLHELLDLDLSPLDYMMKEFPEVREREEMRKIIGRYGLTGRQQVCPMRQLSDGQRCRVVFAWLAWQTPHLLLLDEPTNHLDMETIDALADAINDFDGGMVLVSHDFRLINQVAEEIWICENGTVTKWQGGILKYKDHLKSKIMKENAENASNSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBH9</accession>
    <name>A0A835LBH9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBH9"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="432" mass="48654" checksum="1C86E515926E6EE5" modified="2021-09-29" version="1">MGDKGDGETFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDYSVHRLILGTHTSDEQNHLLIASVQLPNEDAQFDASHYDNDKGEFGGFGSVSGKIDIEIKINHEGEVNRARYMPQNPCVIATKTPSSDVLVFDYTKHPSKPEPSGECHPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEGRVIEAKSVFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRCNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQTTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEEPETPASELESGVNVNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBQ8</accession>
    <name>A0A835LBQ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002571">
        <property type="entry name" value="Protein odd-skipped-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="324" mass="35988" checksum="9B421084E2B42151" modified="2021-09-29" version="1">MQGCLIKHDSRSINLNVHQPWDDALETVMSDNAGAVVSRASTPRPVNDTPVAAPLRSRHDQFLASSAERAQQRPSSSGRNPSGSFESPPLPYHRQMTTGSLLTSSHRETSAFVPVVPTRSMHPVIYPNEMHPALIPSEIIERERMMDRERTEPAKGSPDRASGNFPKRNSFDLMAMMVEKRKEVALREAAAAMLLPHHRTSSIEGMMSDGSSQPPIYGPPGPFLGAPGPSPTAAGSFTFPGAGLFPPGAGPHQMHPHLDRRLLRAPGRASRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC45</accession>
    <name>A0A835LC45_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="89" mass="10087" checksum="A43678F399B600F4" modified="2021-09-29" version="1" fragment="single">MGRSQELLNAAREGDKRTVEKILGQITNISGPFTSFKNILQVGKPRGVELPVPVTEQVSKLEKPEEPIWFVNKRNQTKVINIKNETCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCU7</accession>
    <name>A0A835LCU7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCU7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="434" mass="50455" checksum="9295D8B84B90236D" modified="2021-09-29" version="1" fragment="single">YYKKKDNKNGSSRWNCKYKSKRRGTITIKGNTIMNKVSHSNNCVRDHAGNEIKKEISTWKVESGQGVLPLQTIYNEGVNRLKDPDLCLNLLTRIPNFNNVKHGLYNSRRKEFGIDNIKPKTVTDVKVPVKYNDFLMADYQEGARRILIFSSKEAREKLKTVKHFFADGTFKCVVPLFVQMYSIHGDLGSTEKSTNIKPLIYALVTDKKEETYQIIFQLLLSQNPSWKPEKFTTDFESAQMNAIQSVFPEVDIKGCFFHFTQALSKKAKSLHILKNRACKRHVALCAALALLPEQATDEGWFYIMEDWSEENENLVKFNDYFTKQWLQKEDMRRIWCFNSERHRTTNSVEAWHSSINKKLCGNTKPNILQFLSIIKTDASMTSLTIAKLENGHQILNKRKEYIEKDEKIAYILEQLDNNYINVGHCLEKLLTYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCX1</accession>
    <name>A0A835LCX1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_006991</name>
        <name evidence="12" type="ORF">HW555_003770</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000448">
        <property type="protein sequence ID" value="KAH9637347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCX1"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9637347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="26510" checksum="2CD2ACC1A43F7823" modified="2021-09-29" version="1">MGRKFVVGGNWKMNGDKKQVTEIVETLKKGPLDPNVEVVIGVPAIYLEYVQSIVPNTINVAAQNCWKAPKGAFTGEISPAMIKDIGANWVILGHSERRTIFGEKDDLVAEKVAHALESGLKVIACIGETLEEREAGKTEEVVFRQTKALLPAIGSNWDKVVLAYEPVWAIGTGKTASPQQAQDVHASLRNWLSANASADVASSVRIQYGGSVTAANAKELAACPDIDGFLVGGASLKPEFVDIVNATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A385H8Z4</accession>
    <name>A0A385H8Z4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pigment dispersing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_012768</name>
        <name evidence="7" type="ORF">HW555_010096</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2018" name="Insect Mol. Biol." volume="0" first="0" last="0">
            <title>Identification and expression analysis of the Spodoptera exigua neuropeptidome under different physiological conditions.</title>
            <authorList>
                <person name="Llopis-Gimenez A."/>
                <person name="Han Y."/>
                <person name="Kim Y."/>
                <person name="Ros V.I."/>
                <person name="Herrero S."/>
            </authorList>
            <dbReference type="PubMed" id="30171635"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod PDH family.</text>
    </comment>
    <dbReference type="EMBL" id="MH028121">
        <property type="protein sequence ID" value="AXY04290.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000107">
        <property type="protein sequence ID" value="KAH9643893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A385H8Z4"/>
    <dbReference type="OrthoDB" id="8178425at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009396">
        <property type="entry name" value="Pigment_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06324">
        <property type="entry name" value="Pigment_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036073267" evidence="5">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AXY04290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9643893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="109" mass="12564" checksum="7F984607616D574B" modified="2018-12-05" version="1">MVNLVRRVVFLFLTLVITNEVFANDYAGEPDIESYGEEELAEMIPSMENDKYIRHIHSMINAYRDDILGRRMVIETNALVDTKYKTWKRNGDLINSLLALPKGMNDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1L2</accession>
    <name>A0A835G1L2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000956">
        <property type="protein sequence ID" value="KAF9404515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1L2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="34165" checksum="5CB0E8BFCE72E933" modified="2021-09-29" version="1">MYDVIIIGAGPAGMTAALYASRSNLSVLMIERGAPGGQMNNTAEVENYPGFDSIMGPELAYKMYENVEKFGTENAYGIVMDIKDQGSYKEVICDDKTYQTKTVIIATGCEHRKLGVKGEDEFAGRGVSYCAVCDGAFFRNKKLLVIGGGDSAVEEAIYLTQFASEVVIVHRRDELRAQKIIQDRAFANEKISFEWNTVLEEILGNDMVVTGGQLRNVLTDEVKEVPADGVFIYVGLDPLTEPFKNAGLTNDEGWIETDQDMKTSMPGVFAIGDVREKTLRQITTAVGEGGIAGQQVYKYIEDLSEVEEVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1T1</accession>
    <name>A0A835G1T1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_014263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000938">
        <property type="protein sequence ID" value="KAF9404590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1T1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9404590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="24614" checksum="2A48FD141889CF27" modified="2021-09-29" version="1">MNHLIDELDQARYTTLEQLVDQGVEVLLNTDVTKINAEKKIIICEGSDERVAEVKYDKLILATGSNQFSTNMTLPSEDKVTVFKNYPSSVAVLERLETSQTISIIGGGYIGVELCDALKDKGKEIHLIESADSLLFRYEVLPMKAEEKKFYDFIMDRTKAEHQEDMKHLLAELMERRTADKLDKMYLMSVVPRALSYLDPDAVNEVKKAVSEFSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1V3</accession>
    <name>A0A835G1V3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_014180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000892">
        <property type="protein sequence ID" value="KAF9404759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1V3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_uS9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9404759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28075" checksum="23DEA5F890A55D87" modified="2021-09-29" version="1">MSPGNSSVCQTSNRKLEERNVRTTYMAKSGEVERKWYVVDATDIPMGRLSTVVASILRGKNKPTFTPHVDTGDFVIVINADKVKLTGNKASDKIYYRHSQYPGGLKSVTAGELRDKNSRRLIETSVKVQYSGTGRRKKSVARVRLVPGTGKITVNKKDVEEYIPHADLREVINQPFGVTETKGAYDVIVNVNGGGYSGQSGAIRHGIARALLEVDPDFRGALKRAGLLTRDARMVERKKPGLKKARKASQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2Y4</accession>
    <name>A0A835G2Y4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000692">
        <property type="protein sequence ID" value="KAF9405718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2Y4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14480" checksum="E22393B0E0C5825F" modified="2021-09-29" version="1">MQARYVRRKQLNQYLPASLLRAHLPRYQQLFIDTLTPARALTTSCVPRRNRATPWEETNWNEGSDTAESFLEDLDHLFSTTSESEAEPEATPQLVQIATSLNLGKIGNLKMCHITDIGSNKELHQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G327</accession>
    <name>A0A835G327_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_014447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001041">
        <property type="protein sequence ID" value="KAF9404236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G327"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.320">
        <property type="entry name" value="Putative peptidoglycan bound protein (lpxtg motif)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054360">
        <property type="entry name" value="InlK_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009459">
        <property type="entry name" value="MucBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22122">
        <property type="entry name" value="InlK_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06458">
        <property type="entry name" value="MucBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032884421" evidence="5">
        <location>
            <begin position="21"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Internalin K" evidence="7">
        <location>
            <begin position="290"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MucBP" evidence="6">
        <location>
            <begin position="479"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9404236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="621" mass="67473" checksum="448E0349E8630F86" modified="2021-09-29" version="1">MLLVLLAPTLLSSSLALADGSENEVDQTTTAQTTATEETQEETLDSSASTESSTTEEMSETDTEVGTDTSSTAQEIAATTTPTAEPLATNADAVTIPDAALKQEIVATLNLPVGSDLTKTDMERLTSLDLNSSNSAQISSLSGLEYATNLATIYMNIDNNVTDFSPLEQLTSLTYVTLQTASLNSANFPDLTKSTGITNLNLGGTDIDNNVFPKITQLTQLKRIYLDSNMKITTIEPLKHLPNLTSLSVQFCGITNFTVIPEFPVLNNLAAFGQNTGRYDEPTTIGRSSLDYDIAQQTIFLPFSMMPNRMTNFDGYVPPFSTSNSASNTYLDFNGQQLPSNRLQITDQGITVSGVTEDEFKNITSFEYNARLNNPAGTYAQPDGFTFYAISSGTYLHQFNVLDDGQPVTVQYKDTKGNELLPDEILTGFVGKTFAISTPEIAGYTLKETVGEPSGSFTNQEQTVTFIYEEVSVIKKKGTVIAHYVDTDNHTIKTDFRFVDVIDAPFTLEQPKIEGYTFKEVIGATSGKVTEEEQEVTYIYTKNKIEEKTDPSKTTAATNQNSANNSTSNNNETAQKNTAAATKKVFPSTGEKAASSLFVLGIILVAGAVAYFMFRKAKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G353</accession>
    <name>A0A835G353_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="5">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_014200</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000900">
        <property type="protein sequence ID" value="KAF9404718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G353"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02803">
        <property type="entry name" value="OYE_like_FMN_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1510.10:FF:000001">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051793">
        <property type="entry name" value="NADH:flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010030">
        <property type="entry name" value="PRK13505.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917:SF2">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(2E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="309"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="404"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9404718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1270" mass="137571" checksum="C1190A9EB9507838" modified="2021-09-29" version="1" fragment="single">RAKGGTGLITLENVCIDYPMGTNGARQLRMDNDQYISGLWNFNEKMHAYGACTSVQINHAGASAYGLRLEGAQPVSASNIPSKKGNPIPRPVTEDEIYQIVERYADGALRAQRAGFDCVEIHAGHSYLLSQFLSPLYNKRTDKFGGSPENRARFTKLVVEAIRKAVGPFFPISLRFSADELLEGEEVDILNVSAALNDSLQYQIDKMNLADGWRAYMSKAVKERFPDKVTVTSGNIRSPKRAAEILESGDADLLAMGRGLIAEPNWVNKVANGQENLLRKCISCNIGCADHRIAKARPIRCTVNPDLHYEDEYKMKPVLHPTKMVVIGGGTTGLEAAATAAEVGISVELFEQKDYLGGLGHEIARFPDKKRIDDFITYEINRCKELDNLSIHLNQAATLADIKAIGPDIIVNATGAKPLLPPINGLKEQLENPQRKIFSIFDILGDMSKFQEFEGKEVVVIGGGAVGLDVVEYYAERGAKKVSIVEMQGELGKDLDLITKLAMMEIVKNYGVEVHLETKLMEVKENCFLVEKDGEQLEVPFDLGFVCLGMRAEAPMIRELDNYARENGAILLNMGDSKVARRIMEGTREAHELSPAAKLVGAVNTVTNKDGKGHLVGYITDGTGAMRALKEEGVEVKDKIVTMTGAGGAGTAIAIQAALDGVKELHSKAAEKEGIELEAAPVTKFKSKPKMHIEAMWLFPTPTVLIVGSVLVGFFAAGGVMQLGLTVMGEMFPAESIGLTEDDLELFGKYKAKVNFSTMQKLTNNEEGKLILVTSINPTPAGEGKSTVTIGLGDALNRIGKKTVIALREPSLGPVMGIKGGATGGGYAQVLPMEDINLHFTGDMHAITTTNNALSALLDNHIQQGNELGIDARRIIWKRVVDLNDRELRQIVVGLGGPIQGVPREDGFDITVASEIMAILCLASDLEDLKFRLGNIVVAYTFEREPITVSDLGVEGALTLLLKEAIKPNLVQTIYGTAAFVHGGPFANIAHGCNSILATKTALKLGDFVVTEAGFGADLGGEKFLDIKVPNLKKAPDAVVIVATIRALKMHGGIDKAELNIEDISALVKGFANLQKHIENMKSYGLPVVVAINEFVNDTPAEITALRDLCEAIQVPVELTSVWEKGAEGGEALAKRVTQVIEGQSANFRTIYQVGMDLEEKIKTIVTKIYGGKDVVFSKKAKTQLATFEKYGWDRLPVCMAKTQYSLSDDPQQLGRPDDFTVTIRELVPKIGAGFIVALTGDVMTMPGLPKKPAALNMDVDKDGNAIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3W0</accession>
    <name>A0A835G3W0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000605">
        <property type="protein sequence ID" value="KAF9406353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032459291" description="Carboxylesterase type B domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="544"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1572"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1599"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1615" mass="179179" checksum="FDBB94FF68025D85" modified="2021-09-29" version="1">MWKCTLVFCSILVLVQGQDDDWLQVNITQGPVRGRKDPDGGLYVFYNIPYATAPTGRDRFKPPLPPPVWMSPLDAVNRNIRCPQPNVLEHTQEDCLVVNLFVPDTTDTNLPVLVFIHGGAFQNGHGLSGQYRELVRTNKLIAVSFNYRIGVHGFLCLGTEGAPGNAGIKDQVTLLHWVNTNIARFGGNPQDVTLAACSAGSGALDVLTLSSATTGLFQKAILESGSSTGAVGVIIDPIQNAKNYAKVLNFDNVDDLESLEEFYRTAPFELLTSRVDEIVDNKDTAVRFAPCVERDIGQERVITDAPMNVIKRGNYTKVPLLYGFTNMEGAMRLPYFDIWKNQMNEKFSDFLPAELHFDDDQVKEQVAQKVKQFYFGDSDVGEDTMVSFLLYFTDVLFAYPMLKSLSARVEALGDTIYLFEYSFVDEDTPSFPHTDVRGAQHCFQSRAVRDQDLTGRTDAYRRMVQIAREYTLNFILTGSPTSSDARFPLWRPANAQRSPHMSIGPVIELRDDILGDRAAFWDSIYEEHYRGPIVPDTNVRADGSRVVNITQGPVRGRLLPGGGVYGFYNIPYASAPTGADRYKAPRPPPTWLTTFEAEDRKIMCPQRFTSETMNIQEDCLVVNVFIPDTEETNLPVHVYIHGGAYQFGFGLQGQFTELVKRKIISVSFNYRLGVHGFLCLGTEAAPGNAGLKDMVALLRWVNTNIASFGGNPDDVTLSACSAGSGSLDFLTVSSLTNGLFKKVIQESGTVIGAVAAQVDPIQNARNYAAVLNFDNVNDLNSLEEFYKSVSIQQLVSRSDAIVNNEGVTSRFGPCVERDVGQEIFLSDAPMNILSQGNYTNVPRMYGFTNMDGSVRFSVFDTWKEMMNEKFSDFLPSELHFDSEEVKEQVAERVKQFYFGDSPVGDHNFLSYIYYNTDVLFSYPMLKTLSTRVEALGDSIYLFEYTFVDENSPGFPQTEEIGARHCAQEMIVSDGDVTTATDEFKRMQEIMRNYWMSFISNGYPSSSDPSLPTWRPANAQRSPHMSLGRDIVLKESSPIPERAAFWDEVFEEHFRGPIVDPVAPTPTPTPGAASSLRSLTIHYMTPPTLNGKKAIPGALLARKFGDESRVVNTAQGPVRGRLIPGGGVYGFYNIPYASAPTGADRYKAPRPPPTWLTTFEAEDRKIMCPQRFASGTMNIQEDCLVVNVFVPDTEETNLPVHVYIHGGAYQFGFGLQEKFTELVRSKKMISVSFNYRLGVHGFLCLGTEAAPGNAGLKDMVALLRWVNTNIASFGGNPDDVTLSSCSAGSGALDFLTVSSLTNGLFKKVIQESGTVIGAVGAQVDPIQNARNYAAVLNFDNVNDLNSLEEFYKSVSIQQLVSRSDAIVNNEGVTSRFGPCVERDVGQEIFLSDAPMNILSQGNYTNVPRMYGFTNMDGSVRFSVFDTWKEMMNEKFSDFLPSELNFDSEEVKEQVAERVKQFYFGDSPVGFPQTDEIGARHCAQEMIVSDGDVTTATDEFKRMQEIVRNYWMSFISNGYPSSSDPSLPTWRPANAQRSPHMSLGRDIVLKESSPIPERAAFWDEIFEEHFRGPILDTDPVAPTPTPSPGAASSLRGLLSDENGSWQTGSDEICLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G401</accession>
    <name>A0A835G401_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000887">
        <property type="protein sequence ID" value="KAF9404778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G401"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="258" mass="29132" checksum="85EE91900B17BBF8" modified="2021-09-29" version="1">MVISCHVDLGSQCSLIKISKAKELGLDIKYSPNLPVLRGIGANLTCPVGMITAEVEVQSIKKVIDIYVVEDYVLSHPALLGHSFTEMPDLIITKTPNKLLFKKIDSTKVQLMCLNDICIPKRSLHVVRVKSDLSFTGNVYVRGSLRGEEDTTNVIPSEDLTVIRQSASENIKTQQLKDIERFNSRRKSSKRYEAGDLVRVERQVPHDGKSHKLVVKFQGPYRVIKVLPNERYVIEDTPMTRKHGRRYEAVDTAMAIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G404</accession>
    <name>A0A835G404_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000729">
        <property type="protein sequence ID" value="KAF9405496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G404"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032858314" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="90" mass="9608" checksum="B33EA08D308AEC5A" modified="2021-09-29" version="1" fragment="single">WRPLHVLLLLPALLLWSSSAEAGPLFESLSLLPSASNVSEHLQHQLAALELLAGLASLAADTAGAASLFHSILSEDKIDGRCQIIEPHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4R5</accession>
    <name>A0A835G4R5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_012823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000519">
        <property type="protein sequence ID" value="KAF9407007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4R5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF55">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE LBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9407007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="680" mass="76767" checksum="B21D06B3A2F609C1" modified="2021-09-29" version="1">MSTRSGRIRASVIEVSPPRTRKGVSPTRSPARTRKSSPPPSGKTPPPARSRSSGRKSPARKSPSRKPVSKFPARKSPSRTTKETAEPEVVSSVPKSPAKRPPIDIGVSIKLEDLSSKLDSYRRSTRSKRLEYSVKDLTSSITENEYSLDKANGLDSSELYSLRNRRPVEEVAPRRSSRLREFIDNVPDIRRSLSKSLSQSKSISKSVSKSLETFSDEENSEEEYLKQREKSKSVTRRLATPLRNSINNLTHTASKWEFGGRIGSLCLILLIPATVFSILISCRKSCSPISLLDLSAYKSVQVFFSLHSLYFFAVQCIIQAVFAVVPIFGIRSDRMDGSGTRYCFNAFFSSLVTASSLFVLDYLKIINKGTLLNEYLRLAVLSYIFAVILSIVLYVKSGKLTKDKLNQYGNTGYTLYDFFMGREVHPFIKKLDIKIWLSRISNTTSLILLSLIFTQGLLLRMPKKDEVSLENWKQFVSSVELKPTVLVFTIMQKVYILNFIMKEYRITTTFYWQSEGVGYLQAVASALYPYYFTTISKHVADTDLVLSTNTLISASLLFVLGFFIMLVSNNIKYEFRKTPLHLSLANVDSMPTFHGKKLLVSNLWGILRHPNYTGDILIHSALALPGIISGHYLAAAPAILTILVLVHRAWRDHERCKRRYGAAWQRYCKRVPSVLLPKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G589</accession>
    <name>A0A835G589_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_015867</name>
        <name evidence="7" type="ORF">HW555_013147</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000582">
        <property type="protein sequence ID" value="KAF9406504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000864">
        <property type="protein sequence ID" value="KAH9629537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G589"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9629537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="9193" checksum="DACEEE34822A0C38" modified="2021-09-29" version="1">MSLEIESMVRYTSPINPAVFPHLTLLLLGIGIFFTAWFFVYEVTSTKVSRDLFKELLLSLVASLFSGFGILFLLLWVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5A8</accession>
    <name>A0A835G5A8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein CPG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000577">
        <property type="protein sequence ID" value="KAF9406544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5A8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032999125" description="Cuticular protein CPG" evidence="1">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="14270" checksum="6BE098DABBFC4F45" modified="2021-09-29" version="1">MKSMIVAVLAVAAVASAKPYLGELGLGLGGVGLGGIGGGIGLGGLGGGLGIGVGEGYGAGSDYGHSGYAGGSNGYGSSGYGGGAVDVGHDIGHQESDFSQEVHHHQSSGHDVGGAMEVGQGGHNLYGHNNYGTGQSGYGHGYHQGGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5G4</accession>
    <name>A0A835G5G4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase-modifying factor enzyme-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase-modifying factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000434">
        <property type="protein sequence ID" value="KAF9407808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5G4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF19">
        <property type="entry name" value="FORMYLGLYCINE-GENERATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032723377" description="Sulfatase-modifying factor enzyme-like domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="3">
        <location>
            <begin position="67"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="336" mass="38363" checksum="D568DF6F14F25F1E" modified="2021-09-29" version="1">MLFIFIICIFQPVLTSKESGCGCNINRGKDGSLNEENLINSNDIEHCPFEDENKASKYLNTEQMNTLDEMVLVPAGDYQVGTDDIAIESDQEGPKRIVKLESFYLDKYEVSNKNYANFISETNYKTEAEQFGDSFVFSAFLNNTFKEQLKDFRAVQAMWWYKVLGADWKHPHGPDSDIQDIMDHPVIHVSWNDARAYCKWKGARLPTEAEWEAACRGGHSDTKYPWGDKLFPERKHMANIWQGTFPTHNSAKDGYVGTCPVDMFPPNDFGLYNMAGNVWEWTEDSWAGKNPKEKVKKGGSYLCHLSYCYRYRCSSRSHNTEDSSAGNLGFRCAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5L0</accession>
    <name>A0A835G5L0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000613">
        <property type="protein sequence ID" value="KAF9406285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5L0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="280" mass="32914" checksum="E82AC96C70E56FBC" modified="2021-09-29" version="1">MTQQKKIPKIKKIKEELNKEFTFLKNVFSVMALPLQMKEIVNDNPKSNEDVEMPKRARSIAELEEKLEKIKSQNKFSFKNKLQKKSLTSKLNKKIKKTERVKAKVKPVVDKPFADMLKASVEEKPKPNIAKPVFNNEGKLVFSKFDFANVGKKERPNKAEKDPKKILENLKQQEERLKQLEEKEDSNKVKEIKEKIAWKNVLQKAEGQKVKDDPILLKKTIKKMDQKKKQSKKQWDTRVQNVEQKKTERQKKRSENIAKKKKEKKSKIIKTSIKRGRVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5R0</accession>
    <name>A0A835G5R0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000443">
        <property type="protein sequence ID" value="KAF9407713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5R0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="247" mass="27861" checksum="D6BF98C373AB6EE2" modified="2021-09-29" version="1">MDPINNTVAGLMDLFNKRMAQFEAQLQREPAEPSNTSNLAAEFFSFRVFITQAVTTLQQQVELLARNIDSMEMRGRRGILLLHGVPEDKEEDAAQLVVDVVRDRLKMSGFTLADIKRSHRMGKTASASRSRPILVKLRDVAVRDNIWFKKTQLKGAGITISEFLTKSRHDLFMAARKKFGVSKCWTRDGCVYVIAPDGSRRRITTFEDIGTLKPQDAMKFPIEPEIVDTPQKPIIAGRSKRAAAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G619</accession>
    <name>A0A835G619_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G619"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17880" checksum="3D840DAEBCD8202C" modified="2021-09-29" version="1">MPRVSLLSPTSKKRKTWDPDQMKKAIEAVRTKVMGYKKAVKTFSVPRSTLKRLVKDSQESLELLVDKPLGRKPVLPLHLEKRLVKYLLYMESVYYGLTRMDVRKMAYQLAVKNKIANQFRNEVAGRAWMDHFLKRHKDSLSLRRPMGTSYARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6W0</accession>
    <name>A0A835G6W0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6W0"/>
    <dbReference type="OrthoDB" id="446244at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19482">
        <property type="entry name" value="RecA-like_Thep1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010248">
        <property type="entry name" value="PRK13695.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146:SF1">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21629" checksum="D92BA1EEA7528882" modified="2021-09-29" version="1">MASKTYKYFILTGEPGVGKTTLTKKLVKEIVGKGVKTSGFYTEEVRYDRIREGFDVVALDGARGRLARDQNLLKNPVKHKVGKYGVLVEEFEIIALPSLVKPNDSQAHLLVIDEIGKMEFFSEKFKNTIHNIFSPSSDYTVLATIPVRKSDQLIESIRNHKQARVWTVTRENRNSLQEEILNEINKTISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7L3</accession>
    <name>A0A835G7L3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000346">
        <property type="protein sequence ID" value="KAF9409014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7L3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032738">
        <property type="entry name" value="Tbc1d30_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF2">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15733">
        <property type="entry name" value="DUF4682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="213"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122816" checksum="13A2F0F11D4CF61A" modified="2021-09-29" version="1">MQTISVQQPINLKVVRFELDFSDLVNEKSSPVRRKSKKIKVPKINNKKLSAIPPPPLLKNTSQKRGVKDLVEDLLDELYSKQRDWSGQSAIDCSQSTSASFTSCQSNCGEKTEAIERSYLEALDIKELWEQKVEWEERLQATGERLAKCVRIRDRLRRQQNRICAAFTVLLRHITGESGARFGVTPGGGEGPGEGGYAEWLHAMRLVARLPAGVPQHFRRKLWLTLAERHLTARRIDWPSAERACFRGTAQPDDTELGAQILKDLHRTGCSLFCGAEGRENQAMLRRVLLAYARWNKDVGYCQGFNMLAAIILEVMIYLVEAVLPEGYFADDLRGLSADMAAFRDLLRLRLPRLAQHMDHLQRISDGGGVEPPLPDVFTMQWFLTLYATWLPREFLLRIWDLVLLDGNEVLLLTALAIWDMLQDRILSARSADEFYSCMGGGAGAVWEAGDSLVARVVAFGSAPELPRLRSLHRYRVAPPAPPTSAPIYHPPLHSAMQSMTKRGLRLFYSEDEGDSSDDGNKMALATFVPRREDRLAAGDRLSLDIGALKRQYARLRERQRQAHVILAAACARHAAVQGVPTSPTSLTVNNLLLGKSALVSSRGRRLGPPPGAIPPSRQTSTHEKSEPRSRQSADTISWNEEKSRKTLSRRNSVKWKDIKKDKVKQKERKASIDLDEAGDGIIVSEIEANRMIATVRSRSSSETSSYSSHSASSTDTSLCDENERGSDSEPEIPDDEKDKRNLNKYKNISSPSASKPSKNSHHLTKKEPVLLRTPDPDTETTMMLDDKPIKNISEYLDSAAGEPLRTYIDGFESKLKDSLKITNDVTVFNPTNISPCSPRMTTERNEVLQRLNRTKYEENSTSREITRPTSFTKSPNVFTELSPIDLSPCNCGVGRKSPYEYDFEKNFKRPPLNEPISRPPDIIDSFTMYPNFVPDIDLSDKNVSDFESPPGSPGGESIIVSEDEPPIPLKIDKYFEHSPEFFGARVTDPNSADIPNRRSTKRLSRLPKKPDSLTLQSNHNDKIIKEEAERASSLPQSHSFAKKTSEEYKEPDFIAAKNEKLLKQAKKREIFFLQKITFYKQGGKIANEPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7V5</accession>
    <name>A0A835G7V5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000328">
        <property type="protein sequence ID" value="KAF9409234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7V5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="86132" checksum="DA9C8384A202D525" modified="2021-09-29" version="1">MYDPEADTMGAADPFGLIGQIMMACLSGSTLPLSSSWSQGQYNSRGESGVDFGDPVPVAAQPRRITNVNIPRVQQEDSNPSENTINSSLWDCCCPPWCNYASKASEKMENTTVELDPINLENENLVYDSDSCIAPPPTPVEEFASEYEMLPSAAEIQSSRNRRNIRMGRMNPLEDHERKIIIEFCHLLEKSKQLFNGLRELPQYGHKQWHSYFGKTFDVYTKLWKFQQQHRGILDSKYGLKRWQIGEIASKIGQLYYHFYLRTSDTAYLSEAFSFYFAIRGRSYYTQASKEDKCELMVKKLRYYARFIVASLLLKKMKLVRDLLNELDKQISEYGITYEPDDQNEWRIVADEVRSFIKVEPVVTVYHPQEFVVILSHRLSPQTTPPIERTSAMTLILQEVLIVGSNATQLKFSELTMDMYRMMQTLEREPNGEAQHLYDESPRQRCASTPSAFNNKGYNLECGLNKNEGPHKYLLFKPSPNQVFVYLASACDDLLCNGVVLLYISAEGLLVPPSKNHCEEAGGYDVGGLITTSKIDVLGRETTIKEGKSAPPKYKDLQVLHPGDLYPFTRRPMVIIVDSDNSFIFNDMPRLFGQPLIILMSPMELPSNLYPIPGEARVEGSLFTLFLHCPLSALCLCCDIKKMGLMNWERAQSYIDAFLKEAGALVARSRTEYVLFLGDDFLRLLILRFIFCETFLRMHRLFRGRAQHTRCSPPLPNDIYDHPTLTHIFMELLAHLQVRSHFHEPAAAAQASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G929</accession>
    <name>A0A835G929_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_015929</name>
        <name evidence="5" type="ORF">HW555_011460</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000342">
        <property type="protein sequence ID" value="KAF9409076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000914">
        <property type="protein sequence ID" value="KAH9628399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G929"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000003">
        <property type="entry name" value="Kurtz arrestin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="200"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9628399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="438" mass="48960" checksum="7070C77B3A6C201B" modified="2021-09-29" version="1">MEDAGSNKQRQATRVFKKSSPNGKITVYLGKRDFVDHITHVDPIDGVVLIDPEYVKDRKVFGHVLAAFRYGREDLDVLGLTFRKDLYLAAEQIYPATNTTKRPLTRLQERLVRKLGAAAHPFYFELPPHCPASVTLQPAPGETGKPCGVDYELKAFVADSQDDKPHKRNSVRLAIRKIMYAPSKQGEQPSVEVSKEFMMSPNKLYLEASLDKELYHHGENIAVNVHIANNSNRSVKRIKVSVRQFADICLFSTAQYKCTVAETESEEPKSMSARLFKFPFIGIFNKKQSMQSVEGCPVGPGFTLSKVFTVTPLLANNKDKWGLALDGQLKHEDTNLASSTLIADPSQRENLGIIVQYKVKVKLCLGPLGGDLSAELPFILMHPKPEEEPRAAPDAPRVQDHDLIQLDPHPDENGQEQDDDIIFEDFARLRLKGADADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9U6</accession>
    <name>A0A835G9U6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000229">
        <property type="protein sequence ID" value="KAF9411308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9U6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032314142" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13625" checksum="5FB12EC9AD12050B" modified="2021-09-29" version="1">MKGIIILLVIVYAAVGRAQLDECPKEQETNWEIEWLLRHEDCEKFYKCTFGKPVEMSCPDKLWFNLETWRCDWPHNVDCEDRLRLALGRRMPSFVQQALDIQTVTEIIITDDHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAN8</accession>
    <name>A0A835GAN8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAN8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="358" mass="41682" checksum="7D24D2C0090597FA" modified="2021-09-29" version="1">MEDDENTKEENQPSTSKKETRTNSANDLYNDDRQQDDRASNSETSVSATYSARSRIEMANTRPEPPKPVAKREAKAPERKKRTRRQGRVEKRRRSYTRRQVRRATIRRRARMPIEKKERNLSVSTIFTRLSSRSGSRTPGCIHCGHRCCRRRYLKKRAMRKKCKRLAKKFAKRKVLNTKRKVEKAKKSRKTPKLKLLARHLKCEATASKHSKEVQYGSRSNMLSPLFIKTNSALADSASPSLPVYCEVTPDMIVEGLRALITWKQNVQDIMLMNFIKRRYPVNPNDEELLNEIQEKLRIAAIVGIVIQSGEDSWRLSCELLHRRLTSNHVTLFWKAFADTLDPLPRKQEPPKEKTIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBE9</accession>
    <name>A0A835GBE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000202">
        <property type="protein sequence ID" value="KAF9412070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="13700" checksum="6674BDEA6B4C0AC1" modified="2021-09-29" version="1" fragment="single">DGVGTGPNSAEQRGRLLSNDGLEAINVCVCEHARSTAEKKKKRYTNSTICSMSSSFGYCEVIFDRNLTGTQNMNSTESTLSVRYAFSNSSNRCFPFLYSGCGGNDNNFKSYEECRKTCGGRSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBJ1</accession>
    <name>A0A835GBJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003864</name>
        <name evidence="3" type="ORF">HW555_009024</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="39037" checksum="FAD0364FC89C6F78" modified="2021-09-29" version="1">MSCWSNEESLSFLEHYQMEPCIWNPKDANHKDKKKQADAWIRLAELTGRPVKEIKNKKEILMTTFRKHLKKKRESMRSGAGAEEIYNPTWYAYETMESFLLPVYTCNEGINTETTEDDPLIRVSTPSRPPSRSPSRPPSIQAVTNKRRRPASETAEKQMAVAFGQLTNVLGQRQNENIPAHKDDDCDLYAKLLAIKLRELSTDERKIMMYQIDGLFINRISQKSNERHTPYPQYYSRPSSMAGAYSTPSPQVIPSRPTSVNSVYSEPIHNNQSFFPSPNTQTSYSAPDMTKHIPTPIAPAPSTSTAPSSSIRIISDQIINPTPRETNIINMAMLNAFEDFDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBQ9</accession>
    <name>A0A835GBQ9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009263</name>
        <name evidence="1" type="ORF">HW555_010162</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000241">
        <property type="protein sequence ID" value="KAF9410920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000199">
        <property type="protein sequence ID" value="KAF9412133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="223" mass="26272" checksum="2AF3581DEE7E688E" modified="2021-09-29" version="1">MHEFDIDIEEFPKLSDILPTLTKKTSLDYENMPDTMVKNLTIDLDKINIKKFKNKITKIADFMGKNDPVLKASRRQANIKKTDEKKFKKAYTYLVRRKILDLMLQTIYMARHKVKPLEANQYFTNKGTSYRVAFLYQRLKLIHGTMMKRFQDITVTSSLRYTKHTGFFDILFGKGSKDYCLHYRKALADHASIIQLHVLFDNLFKVLGKLHDLNKKIGKRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC78</accession>
    <name>A0A835GC78_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000338">
        <property type="entry name" value="zinc finger protein 383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42212" checksum="DE11527852432D59" modified="2021-09-29" version="1">MDTSNLCRSCMKEVASWEKENFDPRVVEMFCFCTNIAISEDDKLPKQFCYDCAIKIESAFTYITEAHKVDATLKNIISRTNTSIIVEPETQSRHIENLKLTLPDYKISATIDNYDEHILFDGIDLPVSESQIIPEKTLEEIEPVQNSSEGSEECVKEKVNVEETKKTFSKASLLSDHAATHSDERKFACSTCGKRFKRRKQLACHARAHADVRPYACDKCSMRFKIKSILKSHMKVHDGDKQYLCYFCGWSFAQAGNLEVHMRKHTGEKPFCCNECGFRAAVSSNLRRHQRQHQAAKTYVCKHCNKGFYDASGLARHLRTHTGELPYQCPGCARAFADSWKRKTHLMRAHRLALPDIPRMRRDGRTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCK3</accession>
    <name>A0A835GCK3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCK3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="43355" checksum="FF4607E420783BF4" modified="2021-09-29" version="1">MKTTFNDVVNLNGDLNNNNDQVTDNVPILPTEKCHVVDTVDASAYVVEAPGQSPEPSNENALALIDTQNVIVTHVDSDVEWENAAELNDAQCEQTKSLTPDEEKSLRSYLNTLNLATQPDGTNSIEIKTEIEEIINQEIKHRLRKKAMADDFFLHRLGPPRMLDVIDEEGSSGSSMTSRRQSYLSDKRSDVEDLKDEVFEDNKNKLTKQKKMMSTAVHKKSFGKLVPQECLLVGAKIKEPEVSEARGDWTMKTVEKMTGAEVVYLTDTSSSTSSLHEIGDEDDGVDTDVSVRMITPTIEVTDTENFLKKTFISNTDNDKQDIFTNTDKTKDLPIKIMANEKVSEDTDKKNISNERVVKVQVENDQSVNTETIVPEKLSTERIIEVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD70</accession>
    <name>A0A835GD70_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9411994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD70"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="148" mass="17153" checksum="844CD02FC8D18C5A" modified="2021-09-29" version="1">MLSLILYPGCGSVLLTVPAQFIPGRTGAGLLILNGFTFYMKNHQAHGKKQWYCSSRDVHGCRADVITYKGVDGIYYLPSHRTGSMVLIYNDNKYWINNRYQNTINWTCRDRKRLGCNSCVQTTIEGRYLKHKGFHNHEDNYTKYNFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDA0</accession>
    <name>A0A835GDA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000203">
        <property type="protein sequence ID" value="KAF9412061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="504"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="61902" checksum="B2F7797752341C88" modified="2021-09-29" version="1">MADAAAAISTIQSMQIALQLLQTITPTAWQYPHQCAIQDGDSFDFIVVGGGSAGSVVASRLSENEDVNYPAWFTLLARSVYDYNITSTDDGKTAQNLQGKVVTLNQGKMLGGSSSLHHMMHTNGDPEDYNEWARMLNDKKWSFKYAQKYLKKMETLIDQDLLEPEDIQWHGTDGPLKVAKDTRKSNEKYLKAFEELGHKIVSDINAANPAVGYTENLFEIADGFRQSSALGYLGRAKKRSNLCLALSTSVTKIIIEDQKAVGVQATTADGETYKVYAEKEVIVSAGAINSPKLLMLSGIGPKEHLESFGINVVADLPVGQNLQDHACAAIVVKTDKCDDTTPAANPHQFPAPSFNGYVSLDNSTATADYDTINLEFSCSSSDILQLSVNMFSYSYDVSQTIFEATKDRKVIFTLLGLVMPKSRGQVLLASTDPTVNPQVYTGMFSNEDDIDLIARAFMDHIRVLNTTYFKSVGASLVDMGVCKDAKTEYEFWRCYAVAMSATMWHYAGTCAMGNVLDSDLNVLGVDSLRVVDASSMPTLIRGKLYAGVMMLAEYGADIIRNDWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDY4</accession>
    <name>A0A835GDY4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Decaprenyl-diphosphate synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDY4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46788" checksum="57975EE701043A27" modified="2021-09-29" version="1">MSLSRFCRVVRCDLVKVQSSSALVSKLWGPCAAREVSTCSAQRASVAQHSSKPDWNRAVSEAEKIVGYPTSFLSLRWVLSDEIANVALHLRKLVGSNHPLLKTAKNLIYNGKNNMQAWGLIVLLVSKAAGHSPEIPDMEQDKAAGVLHSQRALAEVTEMIRTSHLVHKGLVNMNSRQPIAAEPDDMMFGNKIALLSGDYLLANSCSELANLRNQELVELMSSAVRDLAEAEFLGERDEQNNPLPSRPLPKDQIEEATEWDIITDPLPMGGVIGCAGREWSARHVLAAGALLGKSCSAALKLAGHKPQLQTQGYLFGCHLALAWQAFLDLEAFTGPEPASFSLVGAPLAFTLEARPELYEYIEAGKKSVQDVDYHALYKAVLAGDGLEQTKRLQREHIARAVHVLDSFPDCDARTALANIIVAMHHDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE25</accession>
    <name>A0A835GE25_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sex combs reduced</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE25"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="26958" checksum="6A7C336B035D3B90" modified="2021-09-29" version="1">MNELNYNAGMSSYQFVNSLASCYGNQAPGRTGTPVDQAGHPGLPTPGADYYNPNAAASAYPNACYSPPQVGHHYPQHPYGTPATGAHMQPQTMIDYTQLHPQRLGSSASHMHQHSNPSPGALSPNLMSTPPSQAAGASCKFADSTSTTGVASPQDLSTSSGPGRTSPGFGGVGQNSSGTTSTKLGLTTPIASPVEHKANVNQNISSPASSTSSNESNEANNSSSNTKNSKSSASNSSANPPQIYPWMKRVHLGQSKCKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEN4</accession>
    <name>A0A835GEN4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEN4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39449" checksum="0D6C10693DE368B6" modified="2021-09-29" version="1">MDHLKLTPDKLSWMKSRIWSRMTDAEQCLCLSELLGITLKGKSLASKVLRLEYEAYEPMALKAMKSICDEARDKWPAIHSIAIYHRLGMVPCREASVVIAVSSPHRRDSLDAVSHCIETLKASVPIWKKEVYDGDEPVWKENVECTVDSTPLPTPAPNPAPPVDKTLVQINVSCEELQQRIQNFIERKREQVNVSNIHDFIPNNEADTEETETCARVRTQFVRRGDSKGHLKVHKVHNEWGPQTVAPGDFFPEQRDQTGLPSSIAERVVAIEKYLNIGPVSKDIYKRLKDMEDKIAYLQSVSPEYAQFWKSAKDRDVKQEVAMDYAFSADDIARKIEQLEKGMMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFG0</accession>
    <name>A0A835GFG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000138">
        <property type="protein sequence ID" value="KAF9414250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF340">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="158" mass="17921" checksum="69D4790FD269E8A6" modified="2021-09-29" version="1" fragment="single">MFFYKFVATRFEDAKAALLPGESEEDFDPHAHREIPKPTTYSETMMHMLKGCLGAGLLAMPNAFKRMGILYGTIGMISIGLFATYCIQVLVHAQYKLCKRMRRGYMAYNKSMRVAVQAGPVFMRSCAGFFANAVDFFLFVWQMGICAIYFVFVAENVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFX2</accession>
    <name>A0A835GFX2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFX2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="78" mass="9261" checksum="2F65625F4399FC01" modified="2021-09-29" version="1">MFDTYVTLSADQYNAISKKYEEFQRTCDDVTKEPIKVYSPLSQKNLEELYLIREVSKTLQKKKEEDMKKAAAWQYQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGG6</accession>
    <name>A0A835GGG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF18">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="560"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="736" mass="82724" checksum="135152E4B9558005" modified="2021-09-29" version="1" fragment="single">LINGIFSELQPGYGSPRAEPVTSQGSTLIPAFVAPITITPNGNSPEIKMVGGMSMDVQPDFVPMESKIEEIAVRTNRGKKQKPQANNNSTKLSINERYRRLIPYMTFYYANDLAAPVTDNVKEVEVEKAQILEASGINHANHREPKKIFYPNRNIPRYQGNRLTQHNIASANPTKIYYKGGQNIPNYNPLLSDFNNGVLRNEYENVRLVHKQIPKSQGIAFVPTTRKPYLNLYNEDSPNVRYYLSEKPKYKLVPYEQTPPVKVPENENVYDITKKQVPVLIPKEHVYVKPRPARPHYVYDNVDVQQQTIRKQPSIVSESYYEKQRPQLLLAQPIVQSGFKPILNSPQYSKEPATFTTSVPDIDHDFENQKYNDARLQAPQNENYEDIKPHYYQYVVDQAPTYKPPQATSNTAPLASLLNSLQLNKSIPKPITKENVGASIRTLLQVLNVLKAVPQPNNGDVPVLSTPKPFVPSEQVKVSTPTVDAQSDPEPEQPTLPEAEFPEEPYLAPVNTPSQQLDELTPGVGSSQHFPLQQASDDEGGTPGRPGIDYPILTTIPTTSFDCKTQRYKGFFADPETRCQVWHYCDLNGGQASFLCPNGTIFSQAGLTCDWWFNVRCATTTQLYVLNESLYKYILPHSPKFPEDYSGPLVDKYLTLKFKEMEEEFKKNKNKQSAAEKSDSDEEESEDSGENSAEKEDSREKEDTEVSKDGGSSVSPGASVIVDSPGESGKVERLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGI8</accession>
    <name>A0A835GGI8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CVC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023339">
        <property type="entry name" value="CVC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052294">
        <property type="entry name" value="VSX_homeobox_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46892">
        <property type="entry name" value="VISUAL SYSTEM HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46892:SF3">
        <property type="entry name" value="VISUAL SYSTEM HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51496">
        <property type="entry name" value="CVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CVC" evidence="8">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15465" checksum="ADE1A0AF1EF9F1D7" modified="2021-09-29" version="1" fragment="single">LSRRSHCALPAQNARAPHTHRGTLHKFGCITIVNMLSCRAPRHEGTANLMTHRAIIAQAQIKIILITRLPSQVWFQNRRAKWRKTEKCWGRSTIMAEYGLYGAMVRHSLPLPETILNSAKENDAVAPWLLGEFGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHW9</accession>
    <name>A0A835GHW9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000055">
        <property type="entry name" value="Dorsal-ventral patterning protein tolloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF1">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="276"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="597"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="888" mass="99368" checksum="AAD0E53A81970052" modified="2021-09-29" version="1" fragment="single">SKRDHCNKTVEIYEDVSSPPVTSENFGRPLTCTYRFRAFRGSPKDWILRIRFKKFKVGTLINGTTCHKGYMQIVDGNAKTDVSNRKEPGLFCGEIEQPQTFISETNFVKIVFHADNFTDQTYFSFDSRAEQQFEVYLRYGQHPELYPNRRGEVVAGYHLNTRLPYIKLYIENEEFNIDGQRCENIMTCPMRPITSGSENCPYDYIRIYDGKDESASVIGTFCGMGKFPYSIIGTSQDLFVEFVSSPAGPLLNTGFHFNVGNWPGHVEAPGSKVGTCDWLLTAETLKKSGDTEGIFLSVAHWYPPHTSCTYLMQGFPGQVVRLYFPSFRINRIESPIQPWTGDCGESLTLYDAPRPDDARIIKTFCDTFSRPMEKHDFVSTGNAMFVRFESKTGSYSGSSLYYWAHYDFFNNTRFGEPVPGTACDEIIASWKQRAGRLRSPLNTLVYKQASPGEDVHCLYRFVTDKRIYARVILTILSVNFKEHPYTSVTCQNCYEDRADKLIIWEPFPGGKSPNITAPGVSTTPLPLHLAVQRSLGSCLCAKHANAVSRARPYRVVSSGESLNLQLIVDNAHAAASYFKNPSPLFEARYEFVHGPLCGPAVLAAASDGEIVYPHLEALGYMEPPKRIQCIWDLEIEEKRDIWLHFESIKFASRHCEDGNIQIYLPGRLDPYLSVCGDNVTETEKLPILSAGELGFESLDDPLVMEKEKTRSIRIVFIGSASPARAAFKIAWTGLYHLPKNSDGTLMTSRLTDGETKSPDSGHGCDFICPGEALCIPARLICNGVVNCPNVTSGDRKFWTAEEKRAREAYSEDSLRRLGYLDLLGGLPLGQLHDEAPELCARARSIGGNDWTAPALGAGLAIAIGVCALGAAWRLCCRKRSPDEESLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI26</accession>
    <name>A0A835GI26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_006930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000111">
        <property type="protein sequence ID" value="KAF9415403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI26"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="10">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="52353" checksum="77D7B4EB83AC9484" modified="2021-09-29" version="1">MEAVQSFEVRAAWQIILPLPNNGLADGEVESIIKDYKYPPGADGRPVILNDIYTLRYYIRHDIHKGWRDHAFNRFVSDLIPINRTLADPRGQWCKNQNFSSDLPKATIIICFYNEAWSTLMRTISSVLNRSPPELLEEVILVDDFSNMVHLKQKLDDYVRNTPKIKLIRATKREGIIRARLLPINDVKTPVIVYLDSHCECADGWLEPLLQCIKEDPTRVLSPVVDHIHDTTFEYIAQTIEDLRLGGFNWDLKFDWIGIPQAIGYYDEGFEIWGAENLELSFKTWMCGGSLEIVPCSHVGHIFKNRIPYKDTQKIISRNHVRLAKVWLDEYAKYFFERIGNNLGDYGDVTSRIELRKKMNCKSFKWYLENIYPQLEMPDVYVASGVSQVIRHKQTAKCLNIGKFPEGLKPVLSECFHSTSQKWVMEHFKFDKLDPLIQMEINHYHNLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI84</accession>
    <name>A0A835GI84_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1894" mass="221100" checksum="69057BC706C91648" modified="2021-09-29" version="1">MECSLVRAVRYPHQALEMAHLRLAEVVMGQHWAKSWQITDPYTYTAAPHSPWFEPRPLNCFTFLWKHIRKNLGERHKDLNMKVHEATIKRVDFDEIKQTPEESDVDKLFKIAVASKYMNIEYIIDVLKCGDPLYISKALKCDWIYGDNYAHIINPRNLQNDIIPYMSIKMKKKMLTAISMHIRNESRAVEFYNYCVEIGCYEIMTVEEKETWALQQIASEKEILGKGQDYLWYKFINFEKAFKEMKRLVMITPNRSKRADMILILIESAKTQRDLETLLKYFYERHINEQKHVKENFLDKVLRYFNVYEFDKDCWEALNIMFHNLEVYSSTDYISKNEYRLIADVAKECLRYFNTLLDEEKLWHKEAQAIVHALFQLGDLNFKVDLMKKFAPSEATINHSEIDEKLLRIQMAICSHILYSRPPIPLECTFMYLKGDYVPFCLPIFNALLSNLPVPLCMDFVENLLNKPVSIQKHGIRLAFECFNTENFNTVILSAWNKTKNVSLRLVIFDALYSKISSLPSGQEALFETLKSIILRLQPDDDDEIFNIIKSNKLPEHLVVETIEMAWKVVSQFPPKLTNLIRMQDLIICITNRIHQIRQDIVSEIVDTFVASVFKPHEVETKDKLSYEAISLIDSKWQLTVNFLTYVDENNLDKKIEVTKLILMKSFKPQNYGSIKNRHDLIDIGISFISQLEDSSYNQAPTRYITINKLMQSVIETLQTVFATEEIYILIWKLQLGIVARKTIIKPVNEIAANIFARELGNLVKEFIDKELFFNSFLSQINYVLQDKIQHVCRELLLFEMTEIYWLVLYLLPVYSLEINRDDYVYITTKLNNENNKEMRFYMYNTQAGPGKDEATINHSEIDEKLLRIQMAICSHILYSRPPIPLECTFMYLKGDYVPFCLPIFNALLSNLPVPLCMDFVENLLNKPVSIQKHGIRLAFECFNTENFNTVILSAWNKTKNVSLRLVIFDALYSKISSLPSGQEALFETLKSIILRLQPDDDDEIFNIIKSNKLPEHLVVETIEMAWKVVSQFPPKLTNLIRMQDLIICITNRIHQIRQDIVSEIVDTFVALVFKPHEEETKDKLSYEAISLIDSKWQLTASFLTYVDENNLDKKIEVTKLILMKSFKPQNYGSIKNRHDLIDIGISFISQLEDASYNQAPTRYVTINKLMQSVIETLQTVFATEEIYILIWKLQLGIVARKTIIKPVNEIAANIFARELGNLVKEFIDKELFFNSFLSQINYVLQDKIEHVCRELLSFEMTEIYWLVLYLLPVYSLEKNRDDYVYITTMLNNIQHRIEMIILTGKNLGERHKDLNSKVHEATAKRVDFDEIKQKPEESDADKLFKIAVASKYMNIEYIIDVLKCGDPLYISKALRCEWIYGDNYAHIINPHEEKLWHKEAQAIVHALFQLGDLNFKVDLMKKFAPSEATIDHSEIDEKLLHIQMAICSHILYSRPPIPLECTLMYIKGDYVPFCLPIFDALLSNLPLPLCIHFVENLLNKPVSIQKHGIRLVIGCLNVEKFNTVILSAWNKTKNVSLRVAIFDALYSKISTLPSGQEALFETLKSIILRLRPDDDDKIFNIINSNELPEHLVVETIETAWKVVSQFPPKLSNLNRMRDLINCITNRIHQIRQDIVSEIVDTFVALVFKPHEEETKDKLSYEAISLIHSKWQLTVNFLTYVDENNLDKKIEVTKLILMKCFKPQKYGSVENKHDLIDIGTSFISQLEDASYNQAPSRYVTINKLMQSVIETLQTVFAMKEIYILIWKLQLGIVARKTIIKPVNEIAANIFARELGNLVKEFIDKELFFNSFLTRINDVLQDKIQHVCRELLSFEMTEIYWLVLHLLPVYSLERDRDDYVYITTKLNNVNNEEIRFYICTIDKLVPGKEFITASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI91</accession>
    <name>A0A835GI91_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_006404</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI91"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF39">
        <property type="entry name" value="ALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="15">
        <location>
            <begin position="21"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9416152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="978" mass="109280" checksum="6436B3E79FF47D79" modified="2021-09-29" version="1">MYRVPVKSGISLQRLLVRQKHSSSSIRSTFIEYFEVNHGHKHVKSSSVVPLYDPTVPFVNAGMNQFKGVFLGKVAPPCAKAVNSQKCVRVGGKHNDLDVVGTDGHHHTFFEMLGNWSFGDYYKKEACEMAWQLLLGPYGLKPENLVVTYFSGDVAIGQKMDTDCRDIWRKIGVADSRLMARGARDNFWEMGTTGPCGPCTEIHFVNPDGSLTEIWNLVFINSFRDDNGKVNSLAKYHVDTGMGLERMAAILQGVPSNYDTDLFQPLIKAIEKNSKGVSPYGGSYAPDAVLDAAYRRLADHARMISVCLADGVFPATRILYDEVVETLGTTYPELVTKEIDAKLIIDHEEQGYAKMRSGLKKKMRDLVKQYPEVKTLSDVELPGFVQGYKELKETMAKQKSTEIPGDLVFKLYDTHGLQEDLIKRIADLNKLSIDNKGFWSLLAKHKARHKTAIKEQDNRGQLFDEALKNLRSNGYVNTNDQPKYDYIQKEKKIEFKTLKTKIIGILNEDLDWIDFLDPCSDRPYYIVTKDTNFYCEEGGQEADRGAIYFNQNMVMEVDSVFKLQDFVFHKGHFLLTNEKKTNCVHCDMDVELEIDEERRLKLMQNHTGVHLLNAAVRRVLSKSAICPTGSSVTENGLSLNLSVYGEKLSHKVMMDVQDLIRESIKCNAPIDTRIVDSVQLSREPGVVTIPGETYPEVGTPSRHCFPTSSFQVNIYHRELCCGTHLPTTGALGEFCVTSVKGAGGQTPCIHALTGDKAKQARELFCRAEKLEQVIDLVDPDRKKEEISLIRNELSSLCGTSGAPYGEYAKCLDLLDSFSKREVHKNDLALHSMASTEISEVVSQAEREGRRFVVHFVRVSYLMAGPAAQAALAPRRALPAMLLGCAGGVLVAACSVPPEMVTQSFTARTWLGCAARVFGASLQGDDHDHTHAIMTPSKVSLINCEQLVQDAMRVAIKFAQSHIKENTEQSRNTQNRQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI95</accession>
    <name>A0A835GI95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="436" mass="50147" checksum="82222E3F75973F8A" modified="2021-09-29" version="1">MTIKSKMTTDNILQLPIDILVNIFKLLNIKDLHNVMLTCKLLKDLIKNDNTIWRHLSRDKLIIGYSDKRRPNDLWYNRCRTSQNWCNGYYRIKLVIKHYTNYMPWLTFHNSEILLVSVGSELQCYPTNRKGTPNCREALWKVEVPKIPRHDVRTNDISRFIIKNDIIACGNRDGCLAVYKLNNTRKRPCLQYHVQDCHKKGAVEVSAVEVIDGRNQTIVVTGSSNSSDLQFYGLKKESDNITYICKGNDKNLFNISLYETAGTKCMALNSTSDKLAIGLTGNSRPILLDVNNPRVLMAADATKNRKEAVRDIQWHNDNTLLYVTHAGNLHLLDIRSHELVYHTWDPFRAAFYCVKSDGQCAVVAGSAEYSRCVLFDTRKQIHHTQMFFTQKKASPVYSLDFDPYQLITAIDRGVSVLDFNINTSLEEPKDYSQVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIF1</accession>
    <name>A0A835GIF1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase-activating protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIF1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000022">
        <property type="entry name" value="Rho GTPase activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000007">
        <property type="entry name" value="Rho GTPase-activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="711"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="890"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118444" checksum="B368623D9592E2DF" modified="2021-09-29" version="1">MASERVEWVEIIEPKTKEHMYANLTTGECVWDPPEGVKVKRTDSSQWWELFDINTHRFYYYNASTQTTVWHRPTDCDIIPLAKLQTLKQNTDPQKRRESATQTNQPAPQVPPVLDPVSSNGNSTVASVSKLSPGNAKTVTLTQTSPVRTRRSHYHHRNSGESRRGRLSEDGSTQLCRHTDSGRSSDSSISSAQQRRKQELSAAVCNPPVCTPQLRKRSSAAQAHEAEKWSPHAGLNRSGSFISPRKDASDDSMHEKYFKSVESTPLTRRKLKQQSAGGSSCDSASPQSPSSPLQKPQPTPFLQTTAARPSLVSSISLATDAAASVGSRVMHSLERPHQLSRHARERFSDRHLDKDRLAELERMDRYPEKQAVYSVDKPFRQTSLDLRHNASANWHPTRDFTRRQQAEPERYTSSKTSVSSGSSKHRTPPHEPHHNFMRLSSANEQDNIAAVNYKLKCVNLVEPPLTEPNVQKHNQRLERSTAPRDRTKSRRHKRPVEVEDGAMDGEEEEDEGGSSPLYCNWDLRGMQHLLPLQDYIIQQAKLSSRARYGGGSGSDGESGSSRSHSRSGSESRSLSGHEPDNESSDGGARTPDDDDGSGVYLPHSYAHRPVDVEYMNHGVSYYNTFVGFDRDRQPSPGIHRTSSLGGGGGGGASGGAGGAEVDGAGALYSPVRSHAPRPPLEQDIEIFAKDNLNFNKGIFRRKASVRDLLSWTSSSISAPMVGADWDKAHKKAAIDLFRLVQIYMGDRKARPGMTLNSVAQDILHATFSNEKLRDELYVQLCRQTTENPLRDSLLRGWELLAVCLAFVPPSSAFQPALTNYVNRHRDPAFADAFPEVGKWPIHVQVSHYAGVACKRLERIGFGGKRQPRKPTTDDIDQARIQIFRQSMFGNTLSEVMALQKERFPNRQLPWVQVALSQQVLALNGRETEGIFRVSADVDEVNALKAKIDNWELPDASTLTDAHAPASLLKLWYRELYEPLIPDALYGACVLTYLISFLQQFTAPEVVSQTKMDSANLAMVFAPNCLRCTSQDPRVILENARKEMTFLKTLITNLDTSHVQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIF3</accession>
    <name>A0A835GIF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_006185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1569" mass="164490" checksum="057B6219B2E1932B" modified="2021-09-29" version="1" fragment="single">MPPFRKGLLKRKVDAEDVVQNEGVNTINQTEETDQDLITGQLDAASDTTDSEHEDNTEVFSDHERDEVLFDESADSTFGDDEQADDASDSSSDVTDSEDDGESEEEDADSDSEADSGAESGPAPPSGDSASDEERSKARPAGRVKIKPDAATQHTDTSVDRLADSIHKATVNTQPVTQKDEYSSGDTSDEEDRRNTVGDVPQWWYREYPHVGYDLDGRRIIKPPQRDQIDDFLKKCEDPEFWRTVRDPSTGQDVVLSKQDLELLRRVRAGLVPSAQHDEYAPWLDWFSRDVLAAPLRAFPDHKRSFLPSRDEARAVGRLVHALRMGWAKTRRQLADERRQRRQRAFYDLWGAGSADARALQRHIPAPRRPPPGHAESYNPPPEYLLDAQEMKEWNKLSETPWKRKYTFLPTRHASLRAVPAYERFTRERFLRCLDLYLAPRAIKMRLTIGPEALVPKLPSPRELQPFPTFEAQCLRGHDGLVRSVDFDPSGQYIASAGDDGTVRGQCTFYTFHMTLRLSVLGYCLKVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRASSAGLWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTLRARAAAGRQLWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTLRARAAAGRQRGARGVRASSAGCVCAVWETGSGRCARVLQLGGSVARVVCELVVQGVCVRSVGDGVGTLRARAAAGRQRGARGVRASSAGCVCAVWETGSGRVLQLGGSVARVVCELVVQVCVCAVWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTRARAAAGRQRGARGVRASSAGCVCAQCGRRGRDACCSWAAAWRAWLWETGSGRCARVLQLGGSVARVVCELVVQGVCVRSVGDGVGTLRARAAGRQRGARGVRASSAGCVCAVWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRASSAGLWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRASSAGCVCAVWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGMCACCSWAAAWRAWRAASYSAGCVCAQCGRRGRDACCSWAAAWRACVGDGVGTRAAAGRQRGARGVRASSAGVCVCAVWETGSAGCVRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRATVQVCVRAVWETGSGRVLQLGGSVARVVCELVVQVWETGSGRALQLGGSVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRASSAGCVCAQCGRRGRARVLQLGGSVARVVCELVVQVCVCAVWETGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRASSAGCVCAQCGGSGRVLQLGGSVARVVCELVVQGVCVRSVGDGVGTRAAAGRQRGARGVRASSAGCVCAQCGRRGRGRVLQLGGSVARVVCELAVVQGARVCAAWETGSGRVLQLGGSVARVVCELTAGRAARAVWETGSGRVLQLGGSVARVVCELVVQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIM4</accession>
    <name>A0A835GIM4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIM4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="415" mass="43965" checksum="F834B18335BC076B" modified="2021-09-29" version="1" fragment="single">SRRRRVRRKGKRNTRRGVRSTRRRRGARCRRPTPRERCTPQPLALCMPRCTAHQAWGQQKPPPSRKRGRTEKKIETSDNVVYRNFKFQDSFSAIVTAPLSFNACGLGVIVFACMLVAAIADPKPGVLYSAAYTAPVAAAYTAPVIVLACMLVAAFADPKPGVLYSAAYTAPVAAAYTAPVVSAAYTAPLAYSAYTAPLAAFDIIQCISISVTTTNMFKYFVFICMMAVAFADPKPGVLYSAAYTAPVAAAYTAPVVSAAYTAPLAYSAYSAPLAAYSAYPYASPYAAYYLRNRNVSFPHLVYNKKHKPTHQNIILAALFAVAAAKPGIHSVAYSAPLVAAPVAAAYTAPVAAAYAAPVAAAYTAPVAAAYTAPVAAAYTAYSSPYAAAYTASVAAYNAYSAPLVTAAYKAPVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIM5</accession>
    <name>A0A835GIM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9416683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13105" checksum="6C14EC02F1E8EC2D" modified="2021-09-29" version="1">MTEVGGVYRPHISNNKEKLISLIREKADAATKSELAKKMKVLKGFYTVELSPPRGSEFVKFAADLALAREFLKNKCYLHITVRQAWLLFLVGLEITMWFFLGETIGKRHIVGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIM9</accession>
    <name>A0A835GIM9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIM9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="203" mass="23665" checksum="811508E219C2D3DE" modified="2021-09-29" version="1">MFNFIWQPHTLIPASWFIFIFHTGNSTHKESDINLNSLQNTRTLPYIPCGNRRRDTLRLSRKLRTAHALSVMSGTILRQRAPENAGDRDARIDRHFVPVITKVYLLHKYIPVNMMRFLPKSGSQSASMCTPRSMNELKSRTMIWRISSGSRGIVSRRDRFHEIFPPKSDSCQIPQKRYRRQRTYTPGREVTQAMAGIIKEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ47</accession>
    <name>A0A835GJ47_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9417004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ47"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="23590" checksum="9F34768D5609E3EF" modified="2021-09-29" version="1">MSFSHPHVRARLEKHMGSNLVRLTDKAYMTELEERIRAVNEENLNKRITTRVMDEMERLKRLILVGKTPLKECPPELFHHPVFVFWRMVNREVSRASKKRADKYYRKLKAAQKVDLSMAEEHVPEEVVNGKTLTAEELLSKAREEMEHQKQLDLEKGVRFTDEQFAQLKYETNDIKTLKNLTTVEELYALADRIIGNKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ95</accession>
    <name>A0A835GJ95_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_010321</name>
        <name evidence="8" type="ORF">HW555_005731</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000906">
        <property type="protein sequence ID" value="KAH9628587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032602882" evidence="7">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9628587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="434" mass="49732" checksum="9B57CB19CA9B6F67" modified="2021-09-29" version="1">MKYHTKMNLFVLLIWIATTICVMADTLDEENPYTKALKNNKQWHNVHGYVQVRPGAHMFYWFFFANGTRVNAHHKPLIIWIQGGPGFAASGVGNFAEMGPFHMDLQPRNHTWVKERNVLFIDHPVGTGFSYVTNSSLYARTDRDMAMDLAKAIKMFFRRHKEFRRTPTYLFSQSYGGKICPRLAYYLHTAIEKKSLKINFKGIGIGGGWVDPKESILVQPEFLHMSGGIDRNLYLSSSKVAKQLVRALEIGDYAQADVLDDVLFSTLNKQGEINFNNVYAPSPYPALDELQNTMNRYVKPSLSMVNQTIKWQYLSMGAYDSLKKSFLVPSVSFLEALLDKTKLKIAIYNGNLDVVTPLGGASNWVHKLEWHGAADFAKAKRKRIRGTRNGYYKEMKRLSFWWVFGAGHWVPEENPEAMDHILDYVTDETVYLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJH1</accession>
    <name>A0A835GJH1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000066">
        <property type="protein sequence ID" value="KAF9417734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJH1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032858045" evidence="2">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="158" mass="17609" checksum="45606D85C4E5124B" modified="2021-09-29" version="1">MGKIVLVFSVLAVFLIAESSCQKFIRPTYRPPRPRYTVGPVRPKLVRLRRDADEPLWLNQGDIPRAPSSADHPVLPSIIDDIKLDPNTRTARSLGTPSHVSHGGGSRRSSSRDTGATHPGYNRRNARSIKRSSHRIIPTTPPFNPRPKITPLIYAVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJR4</accession>
    <name>A0A835GJR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_007730</name>
        <name evidence="6" type="ORF">HW555_004215</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000398">
        <property type="protein sequence ID" value="KAH9638423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJR4"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="60"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9419288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9638423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="219" mass="24479" checksum="CAA2A2D2D2E7613E" modified="2021-09-29" version="1">MAEENWNDDSVEAGSMAIDSAPLPLAADIPEIKLFGRWSCYDVQVSDMSLQDYISVKEKYAKYLPHSAGRYAHKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAFEIIHLLTGENPLQVLVTAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECVADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKZ0</accession>
    <name>A0A835GKZ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="13872" checksum="D13FF3340571AA09" modified="2021-09-29" version="1">MWKSLLGHLRTSSPTSRDSLSTIVTILSNKSLKFQNFQLKVTVINIDNGKVRQKAFPKNMKHWKIPIGFVGITYIFDAQSIEASMKNGRIIILSIEVHNYGAYNSTAPCACAAPDNAELIADAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL03</accession>
    <name>A0A835GL03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36159" checksum="E435415226E683AA" modified="2021-09-29" version="1">MEALHGTLAELRSEFRERMSKFEADLNKTPSVASGGASSGLVQDYAAFKRFTFDALECIQRQMEFFARDLDALEMRGRRKILLFHGVPETTKEITAVVVANVIKDKLSMDTFTTSDIRRCHRVGSLTSKTRPRPILVKMQDMGIRDRVWYSKTKLKGTGITLSEFLTKARHQVFMAARDKFGVSNCWTKQGHIHVLGPDGARHRLLSLSDLRAIGEPATILSGLPRWSRGRSAAPPGEFSEAVKMMNTDLTRIVKWSTAYGLKVNPAKTQVIVVGSPRLRSKITWSHVSPIVFNGTTIPYSDTVKNLGILIDRDFSWGPQLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMI1</accession>
    <name>A0A835GMI1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMI1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="17215" checksum="F120CB9768F49C29" modified="2021-09-29" version="1">MLRFRPKLGSERNSEWRCCFCLHVRTGTILLGTWHLMLHLIALGFLAAIVRDPRLLDELERDSAPVPNWSDVARGNEAIPTPLSNVEPPPSSFPQHVESPRDHSLIYHDVDVGALVTVCTLAITFMLIYGAALGKPAHLLPFFCLQIFDFAITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNA2</accession>
    <name>A0A835GNA2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="223"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="709" mass="79451" checksum="CD0A11EF4E86CECC" modified="2021-09-29" version="1">MTSIIKLHCLSGAGNEAPPCYVLQIDEFKFLLDCGWDENFDMDFIKELKRHINTIDAVLISHSDPIHLGALPYAVGKLGLNCPIYATLPVYKMGQMFMYDLYQAHRNVSEFDLFTLDDVDAAFDRIVQLKYNQSIDMKVWRIAAPGEEDIVYAPDFNHKKERHLNGCEIERLMRPSLMLLGAMNADYVQQRRRLRDEKLMTTILTTLRGGGCVLVCTDTAGRVLELAHMLDQLWRNKDSGLVAYSLLLLSNVSYNVVEFAKSQIEWMSDKLTRAFEGARSNPFALRHLQLCHSVGEVSRTPGPKVVLASFPDLECGFARDLFLLWAPNPQNSIVLTARSSPGTLARDLIEKGGDRTIELNVRRRVRLEGAELEEYMQNQRVKLNNTVKEETAGISSDSDSDGELEMWVVTGKHDIPVRHDVRAAGCFKTNKRHHAMYPFHEERTRADDYGEMIKPEDYRLAEIVDAEGEIRDVPPAPPPKQEPDEEMTEIPSKCVSSMRQVQIKANIQYIELEGRCDGESLLRVVTQAKPRAIVGLRANPGALLTLKKHCEAEGIEKIYIPSVGDIIDATTESHIYQVKLTDSLMSGLAWRSAGDTELAWLSAVVTPRAHQRENTTTSEEATSDVSMCLEAAPGGAHSASFINSVRLSELRAALSKLGLSTEFTAGALECCNGTLAIRRLENGRVALEGVLSEEYYKVRELLYEQFAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNE7</accession>
    <name>A0A835GNE7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MG17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_015969</name>
        <name evidence="2" type="ORF">HW555_003385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000914">
        <property type="protein sequence ID" value="KAH9628439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032940672" description="MG17" evidence="1">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9628439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="23231" checksum="E09887E88E09BF3E" modified="2021-09-29" version="1">MKSLLIVASVIALAVAGPAHRGLVDPGQAGPAPAPEFNPIAIGPAILDFEPIAIGPAVIDSHPISVGPAIIESEPVDISPAFVDVMPIDIGPAIIEEPIAVDPVHVVEEAANVPSNSLVQIILNINGVTHVIDAPISLPAAEAVVPTPVHVVEAAPEPVQVVEVAPEPVQVVEVAPKPVQVVEVAPEPVNVVEIAPAEIGTPILPTPEVVIEPAVIGAPQLPQPAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNI7</accession>
    <name>A0A835GNI7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNI7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032928637" evidence="1">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="214" mass="24721" checksum="2360BC1F11209EF6" modified="2021-09-29" version="1">MKFYHLIFFAVLSCVSATPTRDDESKEKYVLATVLFYCNEKGDKIVAAGEVPKKVNMIIKKDVERIYNNKNTKIVPIYRKYSDVPKINEVYNEIRNKHDKVFTSTLPEGLSSRLVEKKSKLFEKNGKVSGIQRFKREFVKNKSDVLDKDIESNVVPTKSQDYRKSLSVYMKAGSPDLEGFVPNTVYYAAQLKYRTNDKIIKTLKAMLNEPKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNP9</accession>
    <name>A0A835GNP9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNP9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032756916" evidence="2">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="126" mass="14386" checksum="43EE4375A0C1570C" modified="2021-09-29" version="1">MKAFVVILIIMISSAVEGSDKSEKSNEVEPRGKAKYALITNLAILLAAKVGLYKLVLVIALTVASLKILLIMVWATVIYKHVPDPYLHYQKSEPFPHFQDKYAHHREGYQALDLIADFIKKRQRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNT4</accession>
    <name>A0A835GNT4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="128"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="44744" checksum="7012B2DCB1762FC5" modified="2021-09-29" version="1">MLSLLLNRFSVSSTTTSVPPLPIATPTASPTSRKFPISHTTTPRPNVTPARHIAPIPHQYTFLSGPVVPVPACTPFVPPPKPDFSAPGRRVSEMKCFEYIWQMKMRSDKAGQENECFEIRSRGMAPYVVGGHFTFEGDYPNMGAIGWKAVIGTWKFLCGCTLISSRFVLTAAHCSKASSRDTTIADVIPKIVRLGDKNIQDTVDDRFDAAIIEIINHPKYTAPKQYFDIAVMKLGEEIVFNMNIQPACLWTKDSITRYGDQAQVTGWGVIESGTLKTSPELQAATVDIIDFHKCNKLLARSCNRNWCGLQPDQLCAGKMGGGVDACQGDSGGPLQVKIPLPILNQGTMHYVVGVTSFGIGCALPGLPGVYTKVAKFIDWIESVVWPEVNATHVDNTKGELTNRCHQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP00</accession>
    <name>A0A835GP00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_003620</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP00"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="16">
        <location>
            <begin position="60"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9420026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="39141" checksum="8F84C653161BFB10" modified="2021-09-29" version="1">MAQSVQTTTILEQKEEKTVTLLVPQAGKRKFEFVYQNLITFAYWHIAGLYGLYLCFTSAKWATIVFSFILFVIAEIGITAGAHRLWSHKSYKVKLPLEILLMVMNSIAFQNTVIDWVRDHRLHHKYSDTDADPHNASRGFFYSHIGWLFVRKHPEVKKRGKELDMSDIYNNPVLRFQRKYAVPFIGAVCFGLPTLIPVYCWGESWTNAWHITMLRYIMNLNATFLVNSAAHIYGKRPYDKKILPAQNIGVSIATFGEGFHNYHHVFPWDYRAAELGNNSLNLTTKFIDFFAWIGWAYDLKTVSKEMIKQRSKRTGDGTNLWGLEDKDTPENLKNIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP44</accession>
    <name>A0A835GP44_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13551">
        <property type="entry name" value="HTH_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="164" mass="19761" checksum="029B3898A12B3E48" modified="2021-09-29" version="1" fragment="single">MSTRNLNHEERNQIIILHGQGLNISQIAVELNLQRTTVRRWVRRYEEEGSLTERVRAPRRRAINEEQLHNMIVSYQESPFTPTRSFAQEYEVSMQTIRNELHRAGVHHRRPAKKIIFTQEQKAARVRFAREYRDFDFTYAIFSDEKCFRSSQQGRRNLWRIDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPF6</accession>
    <name>A0A835GPF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF323">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER BEDRAGGLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="752"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="974"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="127622" checksum="57F6A6117BB937FE" modified="2021-09-29" version="1">MEVVNIGEGRYEQSENVPGSSFDSDASSSAFESNDSDHCSEDLDKTSEDGDLKEDLQKTIPECYKSDSNFSSHTTSITNDEEFQATALCQFMDILNDLDEVLDKSLLACLDDDTKNFDSDEEDLICKIKECIGEGHGESDHSEAPSSLDDNTQVITCSNVQPSAPPIEEMDITSSISERSNLTSLGRSKSFSELTDNDRQALVSSLERASTTADTLRNSMRRLDPIVLPAITAEASCEPLTLPVILFLEHNINMRPTSAPIQLQVTAANLSSDGASGPLIVGRRALLMNRTLSLPSPGESDVTTGDWTGRNTARSTARSTSASSSSTESLNVAPITQNVTSATEERIEETEEPPFGVWPHRMSAMLACLSCTVGIFNISRFAIFSVHFGASFIIQFFILSFLIGIPLFTLHLCLGQVLESGPVDMWRISPIFQGVGVSLLITQAVIGMYSIIGLSWIFVYFRDSFITSNDKYKWALPQEFNFEDAAKNGTYKIQETLPQYFHEEVLQRNLGSNTSYFGTIKFQVAFNLAVVWMIVFVALSKGLRSYGKAVYMLIFLPICGTLVLCTKLLTLIPYDTVINIFAETEWSEFFINSNSWAAAAQETFLTWGLLGACIMQLTSHKNAKNKTNVMLQKESACIVAFTFAVLLLGSFLANTCVQILKNYGYVYIPGSFETVKTTQFLWPISEPMPGNVVSTPVRYMGHYGSLVGVTVWKTGNIARVLSGWQPLQLATQIVPATLAVLPANLLSPAWAVIFYFIIIMFGIAQQLAIWHCVITGIMAINAEALKVWETTITFLSCVFGLAMGLLLSTDAGIRIVHFIDYVWVGSWWQCIVQVSLACGVFVVRGRPYSPDVVVAALYSSRSRLSATLAALLSFTWTVVLPVLLCAICVMDFRVGQQKQMYSWRKPAGYWPVWCRQVAVFLQQGALLLVPIAAFVQTWRYMNKGPPDILDRIQNLYRPRMGVSQEPGLGRAVPLATASAPAPPDPPPKYTPPPSYSTATGARLLNTIRRSFRTLRRITTARTEQSPAEDTTQLPITLSETVERDALVSLETQPPDYSGVFTTPSITITDETDSRVTRPRSSTSRTSLSLTRDYLRRSFVRKSDSAKSIRSSLRRSFKYGGALTSSHEQLVRGAEPMSSTVAMSAVSSSHDSHSRASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPU8</accession>
    <name>A0A835GPU8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="131" mass="14412" checksum="504588E9BB805F8B" modified="2021-09-29" version="1">MVEGAMAGSKKPGPLRKSASCQMYAVAHLNHLNSSRSDTSTSTSSSSENYDTPLRRFNRILRSSVARHWTFFKRARPDFRSRGRSVSDTGLCEIVDSGPDLAYLDIPGISPRRSLQTFGKESNGAPSLFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPZ4</accession>
    <name>A0A835GPZ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9423006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF134">
        <property type="entry name" value="AT07769P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032744504" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="31"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="69"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="357"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="592" mass="62414" checksum="0ABB17003BAD6BFC" modified="2021-09-29" version="1">MLRMTHFIVCIHSKMKSLVFGLSLIVCASALLEVQTNYHDAIGIPAAEKIKALEDASLANEAVTNDNRIVGGALAPLGAHPYFAGLLISLVGTTSRSVCGSSLLSLNRLVTAAHCWFDGSRQAWEFTVILGSNWLHSGGERISTRQVFMHPQYVPQFLTNDVAMIYLPWSATMTANVRPIRLPRNMELWNQFEGHWAMAAGFGKTSDQQQTSASVVSHVSLQVINTNTCAQRFQAGYVTFSTLCTSGVGNVGICGGDSGGPLAAYDNNGEPFLIGISSFAAYNMCQNGFPSGFARVTSFIGFISQHIRYISLVLVASTSALVEVGTGYHQTIGIPAAEKIKAEEEKLLAAQASDNRVVGGAIAPANAHPYFGGLLISLVGVSGNSVCGSSLVSASRAVTAAHCWTDGWNQAWQFLVILGSNLLFSGGTRIATSDVIMHPQYSTANLNNDIAIIRLPTSILFSNSIQPIALPASLWNTFVGNWAVAAGFGRTSDQQAGASTIVSHVNLQVISVAACEAVFGNAFVVPSTICTNGAGGVGICGGDSGGPLVLNQNGVPTLIGVSSFVARNGCSLGFPSAFARVTSFDGFIRQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ09</accession>
    <name>A0A835GQ09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000018">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="537" mass="57740" checksum="2B0B8A270BA0E323" modified="2021-09-29" version="1">MSRVLCRSVLSLRLIRVPMARNASSYLIDDPKYSFLKELGLKEKNVGVYNGKWEANGQVIKSFSPANGKIIAEVQAASPEDYEACATAAQEAWHTWAELPAPARGEIVRQIGDALREKLQPLGQLVSLEMGKILPEAIGEVVEYIHVCDLALGLSRTLPGTIFPSERPGHVLIEKWNPLGAIGIITAFNFPVAVFGWNSAIAMVCGDVSVWKPSDTTPLVAVAVTKIVESVLQKNNIPGAVAALCVGGKDIGEKIVKDERMKLVSFTGSTAVGQQVGVEVQRRFGRHLLELGGNNAIIVNEDANLDLLLNAALFACAGTAGQRCTTTRRLFIHKKVYSEVVSRLSKAFAGVVSKIGDPLLSETLIGPLHTLAAVEAYKKTVAEAVKQGGKIEFGGKVMEREGYFVEPTIVTGLPHDSPLVKTECFAPIVYCIEIPDLDTGIKYNNEVEQGLSSSLFTENLGDVFKWIGPHGSDCGIVNVNIPTNGAEVGGAFGGEKATGGGRECGSDSWKNYMRRSTVTINYSGTIKLAQNIKFGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQL7</accession>
    <name>A0A835GQL7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UMP-CMP kinase</fullName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate/cytidine monophosphate kinase</fullName>
            <shortName evidence="9">UMP/CMP kinase</shortName>
            <shortName evidence="9">UMP/CMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQL7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050145">
        <property type="term" value="F:nucleoside monophosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>CMP</name>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="198" mass="22170" checksum="5A08963A14AA12A0" modified="2021-09-29" version="1">MVPEVVFVLGAPGAGKGTQCSLISKEYDFVHLSAGDLLREERQRPGSEYGEMIEEKIRNGEIVPVEVTCSLLHKAMQNSGKQRFLVDGFPRNKDNLDGWERVMSDKTKLLFVLFFECSPEICTERCLGRGAAGSGRSDDNLDSLKKRFNTYINDTLPIINHYDGLGLVRRINAEVSPNEVFEEVKATFNEVGLQRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRB0</accession>
    <name>A0A835GRB0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRB0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="302"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="482"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="629" mass="71484" checksum="2DBB848384559224" modified="2021-09-29" version="1">MINDISRCSHSLNAELLKFSAQNYIPNMYSAKSSGSRKDARYGNGRTESVLRGKYHGDIAKSWKQPRSVVHRICREKKNLKNAMSYNSNAPTILRVSNLDLEVSDLDMRELFEDFGILKRAGINRDRTGRPNGTADVVFERRADALRAIDELHGRKLDGRALNIQLESYEDNKHEEVHNMKRRYGEDLNRFESRSGSHGRAEAADGGKRSALTAEQLDAELDAFMAYIKEAKRGKLQMYSAKSSGSRKDASYGHGRTESVLRGKYHGDIAKSWKQPRSEVHRICREKKNLKNAMSYNSNAPTILRVSNLDLEVSDLDMQELFEDFGILKRAGINRDRTGRPNGTADVVFERRADALRAMKELHGRKLDGRALNIQLESYEDNKDEEVHNVKRRYGEDPNRCESRSGSHGRAEAADVQMYSAKSGGSRRDARYGNDRTRSLLRGRYHGDIEKSWKQPRSEVHRICREKKNLKNAMSSKSNAPTTLRVSNLDLEVSDLDMQELFEDFGILKRAGINRDRTGRPNGTADVVFERRADALRAMNELHGRKLDGRALNIQVETYKDNKHEEVLNMKRRYGEDLNRCESRSGSHGRAEAADGGKRSALTAEQLDAELDAFMAFIKEAKRGKRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRC9</accession>
    <name>A0A835GRC9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRC9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="366"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="528" mass="59935" checksum="763F292C65D80EA8" modified="2021-09-29" version="1">MHVKPDLGVGDDITVIPILLIHGWPGSIREFYELIPKLVTPRPDHKFVLEVIAPSIPGFGYSQAPVQQGMGPQEVAVVFYNLMKRLGFTKYYVQGGNYGAKIGSVMATLFPNTVLGFHTNTPTIMWSPMAIFYTLFGTIWPSFIVEPTLADRMYPLSQYLRTIIQETGHFHLQATKPDTVGIALSDSPAGLAAYILEKFSAWTDVGNKQAIDGALLHKFSLTHLLDNVMIYWTTNTITSSMRHYTEYKQLWVLDRIPTDVPTWGIKFKYNLCFQPDSILRLKYKNYLHSSIVEDGGHFAAMEMPDVLADDIFDAVDTFIRFHEEKKKNEPQPEPAESKTAETVSAKKSSEPVKKTEPAKKPTEVDYMKAKSVHEFTVKDINGNEVKLDRYKGQVLIIVNVASNCGYTNVHYKQLNELYEKYSSKGLRILAFPCNQFAYQEPGSPEEILKFTKAKQVKFDLFEKVSVNGEDAHPLWNFLKRMQGGTLGDFVKWNFSKFIVDKNGVPVERFGPNTDPLELVPYLEKLFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSK6</accession>
    <name>A0A835GSK6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSK6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="101" mass="11414" checksum="18D73F1F502B202B" modified="2021-09-29" version="1">MGSLSIAYSPTFIAIFFLCSYSYCEPDRDRRFIVLGDNNIGIALSFGGSIGSGVISSSKFKRKSFNARHGCTKKLNRGHAYNRHGSRIWLPWWSPPHIFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT87</accession>
    <name>A0A835GT87_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT87"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009911">
        <property type="entry name" value="Fibroin_P25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07294">
        <property type="entry name" value="Fibroin_P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="364" mass="41539" checksum="1BB7657EE663895B" modified="2021-09-29" version="1">MIDIKCIQQYFVQNSQCTLPSGPAPDSYRVKSVPMYIPHVNVTFILTDVDIKGFNDFKIADVNKKTNTVLLEVEFRRLWIYSPRTIISYHRKGKEPLDLIDYAFIEYLNLSLTLTAPQINNIDMSKNHIYTYVSDSNPKTGLGPIFTDNKDHAFARNPHYEQSIVRPCSIHDVNCIRGFFAYNTQCSIAEGPAPDPFVPDKIFLPTPHANLTFTLNNPQIKGLNNWKIKDINKITGVLVMEVVFDSIVVHTPKCIVTYYRRGKEPLQTADYTEIDYKGLSMTLTIPDLKDPQLSEAHVFTYVPDSKPVYVLGPDIYKMKDPEFQRAIFVAESKVEISLVELFVSQGPILFSKFFQSSICDTAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTD3</accession>
    <name>A0A835GTD3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTD3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="148"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="603" mass="68412" checksum="2F3922D8F5DA0E1D" modified="2021-09-29" version="1">MDPEKKPSSEVTVDDILTILGPFGKFNVFSFIMILFPVFLAGMYSSVYNFEVMDLKYRCSVPECEDYPDHINFTIPHDSDGIPSKCLRYAPFSNVSFYTNDSQCSPHYYDTSTEIGCESYVYLEEHSIVKEGKVTKVQNLTTFSDHQSTIANLLVLPLALIASQQVCSLATVSHTKFDLACQDWKRSLVGTVHNAGFFIAIPLTGLISDKYGRRPALIFASVANGVFGVIRALSVNYNMFVVFEFLEPAFGAGVYTACFVLALELVGPKGRVFVSLLFNTMFILGGVTVTLLSWWLLNWRYLLFIIYTPAVFVFIYIWTLPESFRWLFSKGRYEEGLNVLIRSEKMNNANVPKDHYEQVEKQATKQRDERKCENVERNQSTFNQMLTSSMIWKRLFICSFLWISSTLVYYGLSINAIELSGNRYVNYIVILVIEAPANVCKLIFLDRFGRKKVIATAYFLTGLILINYGFVPVGNWSILLYLGGKFFITLAYNSLYVFAAEVFPTNYRTSLLAMCSTIGRIGSTVAPQTPLLTRFYEYLPTMIFGGMAALSGFLVLTLPETNNLKLPDSLKEAQDQDRRKEVDDTVERSVERTNTTTDNKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTM9</accession>
    <name>A0A835GTM9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_009444</name>
        <name evidence="8" type="ORF">HW555_001704</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000510">
        <property type="protein sequence ID" value="KAH9636248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTM9"/>
    <dbReference type="SMR" id="A0A835GTM9"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9636248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17204" checksum="47A1C145DF686427" modified="2021-09-29" version="1">MGRMHAPGKGISQSALPYRRSVPTWLKLTADDVKEQIFKLGKKGLTPSQIGVMLRDSHGVAQVRFVTGKKILRIMKAMGLAPDLPEDLYYLIKKAVAMRKHLERNRKDKDSKFRLILVESRIHRLARYYKTKSVLPPNWKYESSTASALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU26</accession>
    <name>A0A835GU26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU26"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000080">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF33">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="124"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="624" mass="68925" checksum="B151932838ABE683" modified="2021-09-29" version="1">MALKNLQLFHPVRSEMGYQQRQATPMRAPPTSLSRNISRSAETLAGSTKSKELKTRKARSTDQPGGGMAKGSSVLGLPNLTKGWGRDDDSIRSRSRNGSGSSRAGSVDRSTRGSSTTLNADEDNINVVVRVRPISEKERSCGERLLLEFPGKGQVVCHNTTPSQKAKVFSYNVVFEPEATQEDILEYSGVKRLLEMAVEGFSCTAFCYGQTGSGKTHTLTGPPGLVESGASPFAPEHGLVVRSFVHLFRLISERPESHFILKASFLEIYNEKVIDLLNPGSARKPLQVRWSKESRGFYVENLFTVDCETLDDLFAVLEEGMRNRAVGAHAMNAHSSRSHTLLCVRVRRDLREDAGVVCSTHGKINFVDLAGSEMTKRTHSTGKTLEEANNINRSLMVLGYCIAQLSDGKKRGHIPYRDSKLTKLLADSLAGNGVTLMIACIAPTRSNLSETINTLRYAARAKKIKSKPIVKMDARDALILSLKREVEALQAENQHLRTALHVQTDYNLDSYSQRRTPTQIEPNKLYQLPQSELVELVQLHMEENSALRAENSELFGVRDSLLRDQELLSRENERLLKKLEDVNSVCVRSPIIPARPTYSGSNDNEANIWTNPVSSSASIVSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUP0</accession>
    <name>A0A835GUP0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032461272" evidence="1">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="25936" checksum="E4069994427EDE2E" modified="2021-09-29" version="1">MHQTVTGWALLALISSSAILHTLAYPQHVPLITQATSSVRTHNPQYYSNSLPAPQPEQAQERKFAEKSNALKKVALDDIDEIQTNSISDGGFSWSNMLGMLMQMIFNPGTTGPNKSDSIDTDSVSPSPWANLLSMGLKILTAILGGGASSDGIDKVDNGSSPMQTVLLLACFRVFWLRFCRRCSVQKIPTRSPPWQSRLERYATHPSFSQLRNYLFLVSTIERSTISIICCLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXB9</accession>
    <name>A0A835KXB9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="15">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="15">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="15">PHB:PPT</shortName>
            <shortName evidence="15">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">coq2</name>
        <name evidence="16" type="ORF">HW555_013096</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:44505"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="15"/>
    <dbReference type="EMBL" id="JACKWZ010000573">
        <property type="protein sequence ID" value="KAF9406592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXB9"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9406592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="412" mass="45285" checksum="8FE1891EA8C6CC9A" modified="2021-09-29" version="1">MLNNSIKMYKITQLQNLIQRTISLNAKRKFSVPLTYSCICGQIYLKNTHHRYEITRVHSTQSDQHRQKVVIETTTPKIVYDKLQEKVLPDHRHIDVGPGFWKDKVDPYLKLARWDKPIGIYLLYWPCAWSIAMASVPGTVPLQTSLQTAGLFLIGAGLMRGAGCTINDMWDRDVDAKVERTKTRPLVTGAVSETQAVVFLAAQLSLALAVLLKLNCYSIVLGASSMLLVVTYPLAKRYTNYPQIFLGATFNWGALLGYSAIQGDLNLAICGPLYIGALAWTIVYDTIYAHQDKEDDLKVGVKSTALTFGANTRPALSVCLGVSALSLSLAGQAADLGMPYQLAVLAYIAHAAQQIYTLDMENPEDCASKFKSNASVGAIILMGILAGGYKKYMNNIAEGKNIQDTAKSCLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXH5</accession>
    <name>A0A835KXH5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine protease K12H4.7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000540">
        <property type="protein sequence ID" value="KAF9406851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF5">
        <property type="entry name" value="RE36938P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46204" checksum="BEE7C7F8453406CA" modified="2021-09-29" version="1">MSIKDLDSSIPNLAFLNIDQALGDLAQFIQHVKSDQFEGGRYRNASVSLVGCSYAGTMATWMRMAYPHLVNAAFSDSGPLQPQEEFPEYLEIVAKALAEQGSQECVDAIEAGVQGVLDLLATPTGSAQVSEIFQTCEPLNAASPLDVTLFFGSTVIYHYAALVQYATGTQIANHCRILLASAEPDPVRRLAAVIRRDECVETRYSVLIEQYRNTSYDSRLSTLRLWMHQTCVEYGWYQTTSGSNHPFKSIMPLEYYHHLCRDIFSSEIDETWKRSDIYATTTSVNSFNEEKLRAGIDRTKIFFGGWAHMPDRVVSVAGGHDPWSPLGPNESHAHHNAPVYLVPNTTHCKAILPTSVLDSSELIRVRRAVMDRMHEFASTRPDSPTTVPPTDPTTEAAPGSATSVAASTLILLLTTLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0J0</accession>
    <name>A0A835L0J0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalose-6-phosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000289">
        <property type="protein sequence ID" value="KAF9409913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000113">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000324">
        <property type="entry name" value="Putative Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000150">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="90039" checksum="09DB356D57D0CB65" modified="2021-09-29" version="1">MSGTDSSASRSACNSKGSMIVVSNRLPFILKRNEKTGELERKASAGGLVTAVAPVVIRGSGIWVGWPGIHLDDPNEKIPESNPNDKTPTAGLLSEKIVPIHAEPKLFDSYYNGCCNGTFWPLFHSMPDRATFIADHWKAYIKCNEEFAEKTVHALHLLKQQKGKNGNSPPIVWVHDYHLMLAANWIRQRAEEDEIKCKLAFFLHIPFPPWDIFRLFPWSDEVLQGILGCDMVGFHITDYCLNFIDCCQRNLGCRVDRKNLLVELGGRTICVRPLPIGVPFDRFVQLAQNAKPVLSTNQQVILGVDRLDYTKGLVHRLKAFERLLEKYPEHIEKVVLLQISVPSRTDVKEYQDLKEEMDQLVGRINGRFTTPNWSPIRYIYGCVGQDELAAFYRDAAVALVTPLRDGMNLVAKEFVACQINKPPGVLIVSPFAGAGEMMHEALICNPYELDDAAEVIHRALIMPEDERTVRMNHLRRREQLNDVDSWMKAFLKAMDSLEEEADDIGATSMQPVTIDDFDEYLSKYIGYTQKLALLLDYDGTLAPIAPHPDLATLPLETKHTLQRLSNMSDVYIAIISGRNVDNVKNMVGIEGITYAGNHGLEILHPDGSKFVHPMPMELQDAVVKLLKALQEQAKRAALAEQARKLITEAGFTPAPAHCALEARPPVEWDKGRASIYILRTAFGLDWSERIRIIYAGDDVTDEDAMLALKGMAATFRIASSNITKTSAERRLSSTDSVLAMLKWVERHFSRRKPRANSLTYKNARKARDTIQMHMSYQMPAKTSPRHTPPLTPDKTSSGSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2G1</accession>
    <name>A0A835L2G1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_013902</name>
        <name evidence="13" type="ORF">HW555_013519</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000662">
        <property type="protein sequence ID" value="KAF9405923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000451">
        <property type="protein sequence ID" value="KAH9637086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2G1"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9405923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9637086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="129" mass="13387" checksum="F2744CECD4225A4E" modified="2021-09-29" version="1">MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGGPGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2I4</accession>
    <name>A0A835L2I4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2I4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="651" mass="72733" checksum="97E53AB7B07B0DA7" modified="2021-09-29" version="1">MNTSSFAVDSSRGKTGDAAKTFILPDKCFQKNVGCAWGRGNKFTIYPRSQTVNKTPTNTADNKLMNIKQDILLFTPILRKLVNESNGTYLSLQKAAEAAKVSDNQVEFLKLSRQFRSIIRVCLENLQEAATKTEGIEKNCLLSYITIFYSIECIWHLCEILYIDNIPGDIVLPYLLEWVRFHFPCHEQTAAQLLGACERGSEEHEDYWDTVVGMVVQGRVDVARALLKLHSAGESNEFKLVDNSLRSMPVYSVYGGISTGEFTISWKHWQAECRSKLSSRVLASQPKLELIMKIIMGDYSAFESIRSKYSSWFDILGGWVMFTAPWSRRHELGAAAAACAGMQATGRSHLDDMVRALLEGDLHQVIHEIQQISDNGWFATHLTDILFHCGKLTIMDKHQTNVTSRLRDSLILEYGCLLMEHKSLWPVGLSYLASCPPEGLRRAELILERMPVDTEAKAMKIIAEAKKYELIGVAQSVCRCMSARHLSAGRAGGALCWAMRARCSAASSRAAHAALAHYTRHAALPAQDLLLTAGSAMLLSDTLLFLGKYCDFHRLYKTREFKKAAQLLVSLITSKIAPEYFWETLLLDTLPLLESDEPVFTSNDTYEIMLCLELRSSTLDGEKADLLRLALARNLARTALAEGDGTDEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2U5</accession>
    <name>A0A835L2U5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein O-mannosyl-transferase 2</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_008337</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2U5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9413445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="683" mass="77512" checksum="13960159A039D594" modified="2021-09-29" version="1">MYVFYFNENNSYITMCEKKKSSETAKPINKIWWITFGILCGATFVTRFYKVLEPDHVCWDETHFGKMASWYINRTFFFDVHPPLGKMLIALSGKLTGYDGTFPFEKPGDKYEGARYEGMRLFCTTLGALIIPLTFLSIWEMTKSLESTLIGTMLLLCDVGFLTLNRYILLDPILLFFMSCSIYGAFKVRTLTEDNLQPFSVRMLSWQLFLGASLACTMSVKFVGLFVVLFVGLRTIADLWNVLGDLSKPVSLTVKHLIGRAVTLILWPTLLYVLFFWIHLTVLSKSGNGDGFYSSGFQARLEGNSLHNASAPKSVAYGALLSLKNHRTGGGYLHSHHHLYPYWSWRATATDDNNRWVIKPYDKEQVEGVVLVRSGDLVRLTHAQTGRNLHSHRERAPLTTKYMQVTGYGEDGIGDANDVWKVVISGGKDGDEVQTVRSKLMFVHYLQACVLTTTGKQLPKWVPKVSFEAYASGFIERFFESHAVMFQGNAGLKPKEGEVTSQPWQWPINYRGQFFSGSSHRIYLLGNPVVWWGNLLFLVAFFIIYVINAIKEKRAEAFGTPVPKGKSRELLNAAGWTFVGWALHYVPFWAMGRVLYFHHYFPALVFSSMLTGILTEYLLTSIKSCLSQELGKTVYHCIIGLVLSTTLYSFYLFLPLAYGMNGPLAHEPNSTMSGLKWLESWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L316</accession>
    <name>A0A835L316_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L316"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1144" mass="132035" checksum="38765DC0D13165EB" modified="2021-09-29" version="1">MTLRTPRRRISPRTKRRYRAIREFFRRALGSSSQPDIKISSSIALNVTDLKRKIVGLEQQLDEVNRHCKDITCFDCSRRESESCLRSEARNIRESESSNPSEGKHLRELDSCNPSEEKFVRNSNSYILADAKNEIDTIEEQTETSYEKKLNGTETKFLYKSSDGNYIKSKESENVCNIQDAIDAKQTQDLLDEYGRHITKVKNKKSKLNRSNDHSAKLHKHKARSVYDNIASANSTCSFRSLTEPRMVRSSSPGYSGRHKDRNYSLEYAEAAPSRTHKDKKYREHMKRNKIELQKDYYEQRPLKARKNKNQNRELDQDFIADIIRRQYKPVKMFDRKQSDLSQISAPVCRDQEFPSIREDIQEGTELCSCCYDVTKHRTKYSDLSEMRSICDTRLYSSKRHSRGKRRRIPIEVYDNSDLYDLIPVKEKSSPKTRRKFVEDTMIPYEYYREVPPSPRTLRPKLNLKAQYNTEFEDYMKHAVRKASPHKQRRRRERLDVESDITSVADPKLNKGQLLKTHKNMTCQVEDEDLCQRQQDNATAISLQYPSYTNDQVNATIETTFNKTEEIEMPVDKTDKALCEIKDILQNFLHEIKKETTASQCDKSEISSKDETVENNNINENSTKITGSRMPNSRHSISYNVGCNPSPYMTPFQNPCCYPMMPVCPVNYPISMQSGFMIPSQSYTCTNCVNAPKEPVHTDHCCNKNATTTGTCNTETCHTETEKLIKEIYKFVAQSPNKKKESSVSDRNEARNVGTKMLTSRSVGESSKMSKHDAKVGTAPLRCYSKSCEAIGSRNDSEDYSSQTNPTYSDTVLEKISLEVTQSTIESEMEDIIASEGKDKRNKFSKVLRSFGMFKKKKKDVIEELSESGSVIDVPVKPISQRAPYQQEITNYMMHEPEYYHPPPLTSYYQRPHEYHPDYNPPYNPGLPEYQPPPPIHDYYGPRMPYPGTAEQASAPPLHPKERPTAPPYLSSYDSPYKPMQQPQVPLCLKEIEVKSIGTQSERKMSIFRKIKKKMQPLQPLSHTPPIPQSSDDDNYQKTCSTQTQVAEAKFAPVTKPFFNWKKLQSKAMMGNGSVDVDPMKKFTAIAQKELAENDLKIRRAMMKKLFNKRNPFSSKNLVMQTLLGKDKPHYIEPPVMFKPKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3B7</accession>
    <name>A0A835L3B7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032997402" evidence="1">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16197" checksum="7C0F567E1106ABED" modified="2021-09-29" version="1">MKIFAVVLLVAIAAGVYSNEEQGANMLNYEEKDPNIKMESDQMTTRPHVWGSYGPNDRLISRTVHVISALTLLTNDQEVTYRGHEKTNITSIVVQENGLNGFSTQVDLLDGGLYHNFVTIGLKAGRSYTINKDIRIYATINCFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3J8</accession>
    <name>A0A835L3J8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000208">
        <property type="protein sequence ID" value="KAF9411940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3J8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="304" mass="34824" checksum="18786168BF3204A6" modified="2021-09-29" version="1">MATTWVNRCSEDLECLDLEDEQPLAQLSSMQTDKMTLFFTELLDHDRDDVIIDTDFDQFFERLAHFADWSPNSSEFHILLEVKREFIDHFINPLPAKWGDLPYYRRVCGPEASGINMPGRTTLDGWLARWALHLSEMKRFTDLPLYLQYLCKILFHVIDRTTETCTCMCTYALLSKAMNDELNFVSKLRSVYGTGAITKPALAAFYRSVIGLNAARIDEIIDTAYDRMTSNGYLILDYGTYVHCFTNWLMGKNPNGPGQWVLVPPKDSLPPPPFPVDYSALNTEPAKLEPYAPDKKTNRHSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4T9</accession>
    <name>A0A835L4T9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="947"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1721"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1904"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2122"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2157" mass="242763" checksum="178EF6A2EBA77AAE" modified="2021-09-29" version="1">MTSEIEAIKTNEFLRRRKLRLQQVREQSKDIAKKIRQRAKVEKIRQVSDLDAKKQKEYFECQDKLVKQLQVLYTRGVENVGAGHQSASELTKQDELTKTDVSKLRGKEAVAILRRNKQEKLDQQKKLLDRKLQAREAANEISRDKSSLVANKLLSKFSKVQDCNDLHSKAGGSSELLSSKYDNKVAGKTDNETEPVKTSDMATQWDLETIPHEWEPAVPELSIPTDKDSPNDFDDNGNKAEKNKILDLFAVSEEMPSSLRGNNLLDTREREPGRPSLTIISEYLQNRKMRLRETEPSNINKKPSDDMQSLRQTILRTRTTKPEGSHFNACQVLDEQIVPVPTWRAERRCQFCSHKVHYTTPAQSSTVQKQSRQYKSVTTSRINQIFTSINPMQQADIVPSPVLRHTSPFRRRRTGPGICSNKGACSSDKMKTSQEACGLQRKSSVVMYNHSTRDTRDLPYGDDKLVVRDLQAAEDAYSQAMKEAAVDAKSKEQNKKQQELRNKVAVTKQNVEKEYKDTMNFLNSLPKDKQSKPIKNAYMDEHRQQMQYETRQLRMQQEYKKIQKECKKHHCQKNRNLSKSPVGRDLDVNYANRDFQYSWMPVPESDGNLAIHAIPNSVKSAKQGNSVKFSTMDSYHEYRSRHKHTPPTKDTNQDSAPKKSVIEREDSEYSDSSSISSDTSSVENLKIGPKKRRKNAKEINKDLSDAERIIIYKVLDSKSDKKTKRQTKLLNEIAKSLSCIGKTQKICDEESQQYKKVVSEEGPSKSIENGISLEQLHEGVYKMVEEQGDNIASMYFNDDQESNKVPETQSKTENIANEPCCCRSTNKPLQTDKVTPHFDSGDSHEPRQKSNENRDLSPGLTKKQPNKPSSISTCSYNTAMNDKANTSEGGYIKLIDETGQDAGKVFIGPSGFLNNNAYEVVIQLRKKDGTIEEKILDKDAFFANKQAASETNSTSEGKNISNKSNTDVKDPQPASSEIIHDDCDYRSAANEHSTAVLLQPAVSSKTVLSEKSQAPTDKTEPLHHRTNTDADEEIFLIQSDTNKNMCDKGVHTQSTDDVKQDGMSRPATSTYTQTSLSSPLHRPMYYHMSSSTSTAYLSPPELILPKFLKPDCIMSEDEPLHTIELTAKEYCEEYTDCTCKKCMQARNIIVRKISVKPTHEIKTKYENKNIMTPPNSTITVPEIRRENVEIPKKKKPCKTSTTERSKCSHKTRTHVDPVKRHCHRNKRKTSVESVRSITTRTSTARTGMTSSSKHRCNPISTSRDKKSEKSNLNPIIRDYVNKLLALNRDGLKAVEVADQECSSVGTPASSIINVPYNIDKRKTSLLHTISLEQIKTLLKKQIVQEEFTKNFKHMQHSFVYSVANNKNSMKSLSRSVRRKPVHKVKSLNISRNLVKRRPTEGKSSKPVLQPPTDGNLKSRVDFHSPKKVRSKSSPTPRHVSNSEPISRCDDSESATKNSTGTEKSDDNCNKKAINNKCVRQHIKKLPSHRATLTDSTVDSISESTVDLQHYPNSADIPVSMSTQTTNIELNTDSNLMKLAEDKLHNMEKIADLTEKCTKRLSDLARVLQEVRKNKSLVYSQISSAESTDSQPDHKSEKSTVSPIIFDSNDIAKGEEIQSPDGINDPVEEKEKDIGNDIPSPEYMTILSDIPKPDKAQESKHVTKFTEATEAFDSALHILSTNSSELSVKNRPKPPPALSRLSFKHGQDFVIPHELSTVIEVDSPMSVKHKTHSARNNDKETSNNNSNRSSVGDITAVEDHRKNRSKRGSIMNPDLLQTNLQLSNKYKLSSAESSDESKFQMIDLKQFNEIMLEPFISIQEYAKQYNMEPPDEGSNLEEIHREDPVNDDISSLHSDGSLPDVIAELLKRNVITEPFKFDTASNVNSTTISSESTLSMLALSKARRSRKKPSAISKNKENIGETSDTLSISSNPDLENAFKKLGMGWASSTLKKTKERLALSSSSNTSSSSLSQFKMKSFNQDIPVLVTDSVSSVVNVSKGVQNMSAVDYSKNAEQQTTLSNSMTVKEFLRKELAKKITFTNKSNVNGSQEFVSLFETKMPEEMKENSQVNRDEHSIDSAPSGANRARTSTPVQLFKSMTYHSSSSSNVSNGLFSNVDDLSSVKMTSNSMKNHSTSDKDDLTIPNFSLRLKKSSDCSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L537</accession>
    <name>A0A835L537_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L537"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="71892" checksum="D098DD4B300C47EB" modified="2021-09-29" version="1" fragment="single">MTKAQWVDFNTRHTLLSQEIEDKNINYFMDDIYGKTKIMYENTKADMVKLLQAAEENVKFDLSDLSAGEADEKTKTLLTQQECNFKAIDRAMGKIDFDNVSEKWELDDYLAILKSKWERIDSTHWELEALLKGSKNSYNEMFNSMEAKYDEARKLLKSKMWSTAHHQQSAPKIEIPEFSGHYNKWISFKDLFLETIHKNPTLNKAQKMQHLKTKLKGEAERLVQHLSISADNYSSCWAILTQRYDNRRLQFSSFMNTMLQLPVIHKPDAYNLKKLHDVTTECLNGLTNIGFDITSWDPMIVHLMAQKLDCGTFNEYIKSLQDNREVPTLQEFLTFLENQFTAFETMKSSKKESQSAEKAAGTEKHASRNYEHKKWQLKTYHTSYGQCPLCKNNHVLMRCPQFIDSDTKQRNSIVAKLRLCKNCLFRHENETCNSVKTCKECNMNHHTLLHYNKSHNKIANSTSTENQRSGQRPSKETGTASSNHLSANNMEVLLTTVQVKVMTVDGTYINLRALVDQGSQVNLITENAAQLLRLPRNKLTAKISGVGSVSGDYLSEIAKFWESEEVTIKNTDQEPEDHSLTKTIRIVAWIRRFLGNARNSTKRDTVCLSFCELSNAEELIIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L563</accession>
    <name>A0A835L563_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lancl1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L563"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF21">
        <property type="entry name" value="LANC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39001" checksum="ADBEC966E7D6C1BB" modified="2021-09-29" version="1">MSPKGSFENQYDKYSADVASNILNKSGDGAALDYIDIEKLKGRKISFLCGDAGPLAIATVISYKLDTEHIEHKLPDYKTLALRLTSLISLLNESPDELLYGKSGYLYALLFVNKHISGKEIIPVNHITKVIDSILNTGKQFAIAMKSESPLLWNWHEKVYFGAAHGMAGILYMLLQARSYINIKDIRKYIKPTLDWLMNQRFQSGNFPSSMGSNSGDKLVQWCHGAPGFVPLCILAHQVFDEEKYMKIAQQCGEVIWQRGLCTKGYSICHGVSGNAYAFIQLYQATKKPEYLYRACCFMEWCAVARLGTELHHPDRPASLFEGLIGRLYLSEEMTHVSDANFPAFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L596</accession>
    <name>A0A835L596_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L596"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000160">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23816" checksum="BE468A84FF23625C" modified="2021-09-29" version="1" fragment="single">PVPDAKTGFQQVNEHTDADFAFIHDSAEIKYEVTRNCNLTEVGEVFAEQPYAIAVQQGSRLQEDLSRALLELQKERFLEQLASKYWNESARQACPDADESEGITLESLGGVFIATLFGLGLAMLTLAWEVFYYKRKEKNKVQTFDTKPEKLAFESKTSLESKVAQSVAKIRKRGKIGKKSTVAKNVTFGDSFKPVSEKGVSYISVFPKDYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5H8</accession>
    <name>A0A835L5H8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="3">
        <location>
            <begin position="704"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1314" mass="150611" checksum="D4A639033D592293" modified="2021-09-29" version="1" fragment="single">IASCSYSHIHSQLSENITTSTSARKLTSSATFKIYGDSTTPHSTNDMSLLENQYQLFQELERFRVSKPAVPGTSSEDKPETFVSNRQEGSATPQPQRPEKGSYSRLDESLRKQEANFRAFVRTIANINIENMSEKWEFQDALKTLESRWTLIDSLHLEIDSELMGSDLQYETSFCQHEEQFNNLKKEINKRMWSASYREKSTPKLDIPVFNGNYNSWVSFKDLFTDAIHNNSSMPNSQKMQILKTKVKGEAERLIQHLYISSENYASCWEILNHRYNNKKLIFTSHMNILFSLPNIQHNSVSQIKRMHDVTLETLNAVKNLGVDITTWDPILVHLLSQKLDSETYNDYLESLKQPRELPILQELLEFLESRFTNLETSSRRKQDATLQKINYQHSYNNQKAAFTKSNQNNSLLYNGNRTKTTGHWSIAKSCNVTNFTCPMCKHEHGIYKCKSFLQLADDKKLNAVNKLGLCVNCLFSHNGKECNSKHVCRKCSQPHNTILHDALQKSRTSGSSVAIATPPRDSVTSTSHVSQEVVIMSNLIKRLPNKTFSKPSWTNIQNINLADPEFYVSRPVDLLLGADIYSNIILSGIIKGDDASQPMAQQTQLVHGAHTLEQGQQLIHDLNLLLRSGGFILRKWSSNNNQCLWRTGPRWLSTFQPERTLKQTYQTDEEKNLAKQISFSKIVRILAWIQRALTPRRERLPNYLTLQELRKAKNAILTFHGGPRLTLATLRQDYWITGGNNSVKKELRKCVTCRKHEGRTQEQLMGDLPSPVTKLSILPLEKPNETQPTTTITTNQTETATFVRKKQKQNKGSNYISSLIGFLLCLMAIISSGHCFNLTPLNEHQAIYFDKLANMQLVRDEWKIIAYYDLQPYWEGITAYEKYYKHLETICSTLQQLTHCDIIMLQLRHTYTELKHNNKHLMNLEKTSNVLAQQISTTEAMTEFTLSAMAANNLLTHLRNIQDTLLDTITSIHNGRLNIHLIDPIQFQNELSVISGQLSQELTLPIDNIQTNMQSIYNLLRVRAKMTKNYLMFEIIVPLISTENYDLYHIIPVPHRSDEGMFTILPIESYVAVNLQKDAYLPVTENELEHCITRDPTTYLCELKTPIYKMKTDTDLCIKDNIHPEHCKTLVSACQSKWTHLRTIRILCKDQVTAHQLTGINIISLKEQCVVKTDNFTIYSHKHQESTMSLQNKIETLQIAPINHIINISIPRYNLTDENITYPGHEQLLQDIEQRIQVMKNSSALSEISTHDIHHYTLIYLTLGIVAITAAVVVFRRTRCRRQPAAETAPRGAAPATASSSTVEQFSERVQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Y6</accession>
    <name>A0A835L5Y6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_009400</name>
        <name evidence="3" type="ORF">HW555_004848</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000438">
        <property type="protein sequence ID" value="KAH9637732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5Y6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9637732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="208" mass="24003" checksum="15354AC54155424B" modified="2021-09-29" version="1">MASTSTSELCFFLRIKHFPPVINGRININEFIEASTDLIAVVERLGSVFAPVKYDMQGNIDKLKNIYKYDENSCLLELMLAENANGQPVAAEGVLWLNRALLFFEILFSQILSHVQANDIDISMKKIFTVAYEGSVKKYHNWVTQQIFSFICKMSPTLPQVIKSFEMDNDMKGFETKIESFQKTLHLVRHKIDEFFTENNLFTDQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6M6</accession>
    <name>A0A835L6M6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6M6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="182"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="357" mass="39869" checksum="B2C152F35133A22A" modified="2021-09-29" version="1">MPNTHDVTKYDDVLTSILVNEKSILGFLSAIFSFLARRTDFYYVPQGAYENMGFPPGVAEELVIKVLRTCDPKTWKGTNGAQKQLDLTNEIMCSTVAQEVEVVAENEDDSEDEATPQTQPKSKATSEKPVESSKKSEVNLVKSADETKKSSDPISSTSKAIPEGYKPPDIPVQKNSDTYNGAEQENYLWSQTIMELDVIVKLPPDIKSSKDLQVTINAGDISVASRNGGVIIKDTLPYKIKAMDSFWSMTGGNLLMHLEKVQERWWNRLLNNEPPIDLDKIDCSRPLDDLPEDHVAKVRELQWNQERKMKGLPTSDEIRNMDVLKKAWNAPGSPFKGQEFDPSVLSNSSHTLGSFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6W2</accession>
    <name>A0A835L6W2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6W2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="786" mass="88853" checksum="B19870202F6BFFD2" modified="2021-09-29" version="1">MGCCIPPKESREPIRYDPDFNGPIHNRSCTDIFWLVLFILSLGGWGYVGYYGMTHGNIEKLLAPIDTTGARCGLDSSVKDKPYLVFFDISKCLSPGTPIVGCPTPQVCVPNCPSRTIIFGAEMNEQNFGAYRSDMVCTYDVNVNTLTYTQAVEFISKGKCAPYVLESQAVLSRCIGDLSTLQCQGDSKSSPKTLSKVTDSCVRNPSEARKSLVNRATALDSYVGWIVASWMSFFKQTDERETHIVRSARSCCAWRSSTLMGRCFVNVADVKKILQNHNITEEEVISQIVNLVQFQELSAQIVQDLVQSRWYLLGAVFGVVILCFLYILLLRWVVGPVVWVSIVGLIGLLGFCVYLCYKNYAYYKANPGLLHQTTNLKGYAESMFTKPGTWMAILIAVAIILLFLVLMVIFLRKRISIAIAIIREGSKAVTAVKSTIFFPLFPWVFQCFVIAYGVLVLMYLLSIGESAFKIVNLQNDTTCSCSNGIYTQDYQSCDPVTFLTHCFDQNGGSCSKAMCHFTGLENPHSVVYLHLANLLGFFWTMFFISGVSDMMLASTFSTWYWTYDKRDLPFFTLTSGIYRTVRYHLGTVAFGALIIAIVRVIRVVLEYIDQKLKKFDNPLTKCLMCLCKCFCWCLENFLKFINKNAYIMCAVHGQNFCTSARDAFSLLMRNILRVVVIDKVTDFLFFLSKLLISIGVGVGVYYLLQWNLLYEVTQGQPLHYNYIPAIILSIATYLICTIFFNVYEMAVDTLFLCFLEDCERNDGSPEKPYFMSKNLMRILGKRNKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7G7</accession>
    <name>A0A835L7G7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="101" mass="11005" checksum="F19C214B629D509C" modified="2021-09-29" version="1">MSRSKRYTQNGAKRIASTLRSVSCLCATDGGRPLHPPSADENEMRGTRRRAAVCAPVCVHGEITLVCVTRLPVCYLLDKGGEVWSLSKKDVSTSSIYHIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z1</accession>
    <name>A0A835L7Z1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20815">
        <property type="entry name" value="C1_p190RhoGEF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15789">
        <property type="entry name" value="PH_ARHGEF2_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="8">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="597"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130611" checksum="1F964DA0FFCAAE46" modified="2021-09-29" version="1">MCQYEGGGSSDSRSDSSEDEVTEHVTRSTPPPDMAAARAQVPTISVTPHSPGLLEDSLQQLRRLHAAVQRMRTAPLPLLATGTSRLSTSCPSLCKDGVVEVDCSSPTHLDFYPQSRKGSGESRQWGLWERRDEGRRSSWAALEPGPRTHESHRQRSALNGHSASLSSMESEGEVPRPVRHSTHSLNDNDLAKDFEKVTAALRAGGVVPGSGVVAPVEGGRLAARLPLQKSVSTPSIVAAVQPHLAQPPPNVGAAGSDSESDDASAATVGVTQPARLAANHQDLGLHRLTFLEQAAFDHHAEKRRKRGSLFFRKKKDKSRKTAHAWSAACSGGDCDWCGRALADKPALYCDNCTKTVHQNVCKDYFDCTKPKASKTSVAKSLSANSGKSSKRSSVSSQSQNTNSTSHIYNDDKDGSDHKHDQSNASDDAGVSEWPEVYLTPEQLGDEAIRLGLGACEPDTWAAGAPKGLAKQLGDRETKRQEHIYELILTEKHHCLTIRLMQKGVPECVLFVAQRLTKYPLLLEPLLKTAGDDLTERDLLQRALCGVKEILVDVDNQVAAKEREDRKLEIYHRIDAKSFANFRGRKFKKSDILQGNRSLKFEGVATLMQGRSKMQTLLVIVLTDVLFFLHDNNNKYTFFTPDNKTGVVSLVKLLVREKAGAEGRGLYLICSGPTEPEMFELRVHRPKDIQTWIQAIRAVVQSCPEEVEESEVGATAPSAEERQRQLDARHENIRLITEALRAKDREHATLLEEKMALQMKLVGITDETWLTLPHTGSSTAFPGLVFPDYVRLAAPSADKYALWQDVCKVVMDALEASSAPWQSGGALGRSTSSAGERHSVAYESPALPRRADTFAGFDANRHRVSNVTLRMSTDTPTEGGEAEAEKAGERPDLSGEAALKLQHAIYTLTCIVWQQLTTIHSLEAQVSAWRWQGGGGARTPDWSDAQLEELRHAQARLTRDRAAFDAQRAADHAALNAERQQLQAARQELAEQQKDVEQQRERLFRRLERLQQHAGGSQEEIASVGTLSPDSSVSDTTRRKEPKWRNNRGSTGSESSVSACSARVGVLPPPQLLSAQNETRATVHASAISQMVKQQLPLKLASGKSQQPPPGYHRLHESPSEHQHQNQGLVIHHTRTGSSPAPLPSQQQINNKATRTNTYPKLPDKFRVRSPDTGASTASPPAAASEEEVIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8H8</accession>
    <name>A0A835L8H8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FANCL UBC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8H8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23832">
        <property type="entry name" value="DRWD-C_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.20">
        <property type="entry name" value="RWD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026848">
        <property type="entry name" value="Fancl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044037">
        <property type="entry name" value="FANCL_d3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043003">
        <property type="entry name" value="FANCL_d3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18891">
        <property type="entry name" value="FANCL_d3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCL UBC-like" evidence="1">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="318" mass="36335" checksum="93D5A892EF60E401" modified="2021-09-29" version="1">MEHVVPNIQYVGDTKDLFKLSGCVQDLLQFNTQLIQSVKSDLIDVEILEEIKNITTYENTSVYFGKTLRDIKIVIEDEELRKHEIYLEYKVPKKLIITNLKLPSSIKLNREYSCIKDIIEAVKQNVYDLARYFYELENIDQVCCIMEPVNGSFKDDFRRIFLDDRTWLHVEVTPEGLATNIHLIGQSEHWHNKLQSGLLNWDHDKSIVDNIMTIFDLFQFPQPTFKHGAPLGMDTGDATENAIVCGICLCTELPDSPWCTTTFMPKYILWGLLSQNLSISVLLQWLVACSGSRPPTFGVANGSCPTCLQSITCSEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8S8</accession>
    <name>A0A835L8S8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="14"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="6">
        <location>
            <begin position="553"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1344" mass="153961" checksum="F5A810941E32A627" modified="2021-09-29" version="1">MHEAYEISHLLNATVQIEAIAAYDNNLLLGTRQGHLLMYSLSQTNGNQKYELQLLRYCKNFSKKPIQQIEVIPEENLLLCLTDNVLSTYNINGVNFPLVKTFEQTKGASLFALDNTPTTSMTGESNSVVRLCVAVRRKLQLYYGKNGEFKQHLFDFTIPDVPKVMSWGQQYVCVGFKAEYVLYDLASGNPQELFPTSSSKSLEPTIAKYSETSFLLGRDQTSVLVEEAKNIDIKKTIKWSEAPIAVVWDEPYVLGLLSDQVIVQTVEPSLFIQTLPELNKARLMYRCKRGLIFVSSVGQVWCLSSVDITKQRQQLLKDKHFQIAIELTSLSDCTPEEKEQKIHSIQVLYALELFDNKQYSQSMKEFIKLKTDPVDVIKLFPELDGKTNDDNPKKLVGKDLENALNALVMYLKELRANIGNSTGQDEATKQRNVTQQLELIDTTLLKCYLQINDALVAPLLRINNCRLEEAERMLLQHGKYSELIILYQTKGQHMKALQLLRDQAKEPDSSLGYQETKNYLQQLGAEHINLIFKFSDWILKEHPEKGLKIFTEDKVEVENLPRPKILDFLLREHESLVIPYLEHVIHTWNDTNSLFHDALINMYRDKITDKKANLTDAEVQHIKAKLVAFLEKSAHYTPERVLVHFPVDSLFEERAIIYGKLGRHEQALAIYVLILGDVDRAIRYCENVSATPNDKNQDVYVILMRILMNPQQDSALKENPLAKVPRHPKTSVPDLETALDILEKHADKISPLKALSVLPDSVPLSRLKHFLESALDGQLTLKRRMQVLKGLLYAEHMQVQEVKQFHESKSVVINDYNVCPVCKKRFGNQSAFVRYPNGDISLPTCPREEKEQRLLSIRRLYALELFDNKQYSQAMKEFIKLKTDLADVIKLIPDLEYKSSDDKEKVKKLSGKDLDSALKAMIVYLKAVQSNLGKDTGQGEAANESRHRELIETTFNNICLEQAEKKLLHYKKYSELILLYQKCGQHMKALQLLKDYAKQSDSSLFGYQRTVNYLQQLGVDHINLIFEFSDWILREYPDEGLRIFTEDKVEVENLPRPKILDFLLREHESLVIPYLEHVIHTWNDTNSLFHDALINMYRDKITDKRANLTDAEVQHIKAKLVAFLEKSAHYTPERVLVHFPVDSLFEERAIIYGKLGHHEQALAIYVLILGDVDQAVRYCENSSTNLNNHGQDVYVILLRILINPEKESARDTISKLLANATIHPKTAVPNLERALNILEDHVDEVSSPLGVLSVLPDSVPLCRLKKILENVLESQFALARRLQIVKGLSQAENEQIEDMNQYYESQASLITDGDACPVCKKHFGNQTALVRYPNGVIVHFHFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L918</accession>
    <name>A0A835L918_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L918"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14366">
        <property type="entry name" value="CUE_CUED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040195">
        <property type="entry name" value="CUE_CUED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040192">
        <property type="entry name" value="CUEDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467">
        <property type="entry name" value="CUE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467:SF3">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="247" mass="28115" checksum="B430AB835EC86786" modified="2021-09-29" version="1">MASTMQLEFTQAMTDFKTMFPDMDDDVIEAVLRANQGAVDATIDQLLAMSTDNQNERLRLEMERVESSTPSRRKDRRSGSRPTDNGDDNDTTALVDVEDDSIPLAIRRKWVPRMLGPLPPMFLRIPPGTDARIDLSLEMDDDKIATFLQNEEFMAELRWNQEFMAALDSEQGQKTKCHDDEAAFKERLKNMGKSSRKKFAQLSRMFCRGGSRRSGSARAPPRGPPDSLLLQEEHSDDDDRPQHHVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9Z4</accession>
    <name>A0A835L9Z4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9Z4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="131"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="1">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="32217" checksum="8B2B6FEF414981BF" modified="2021-09-29" version="1" fragment="single">DNETEDVTTTREWHYGNAPNTNNLDFTATAGLKVDMREKEPIDFFFLILCPSILNLIMTCTNRYGEDLKNAASAIHSRMKEWQAIDMGTLKTFIGLVIHMGTIQYSRMSDYWKTHYLFKNDIFRKYMPRNNIPLTRELLNSRTFCTGTLKMNRKGNPKELLKTKIKKGECIILHDKNNITLAKWMDKREVLFLSSEHNKRLLPPIHPREEIPLAICPMHFPKQITKEPNSRRAKRKQCRQCAKQKKRVDTIFYCPNCPDQPGLCLNCFKPYHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBC4</accession>
    <name>A0A835LBC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="156" mass="17512" checksum="76A279D3C2AD46A0" modified="2021-09-29" version="1">MLSVKCAVFRCSDSVEEMSTLSMRAPGLQTTTVLDTRTLRMRGVTALEGVRRNLFGSTDREENRRFVERELARQLELDSQRWGFDFANEKPLPTSQRFAWQLVPASTIPAALRRSPITVTTPTASKPTQEAKVSSPDNSKTQKRITDPLIALMDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBH6</accession>
    <name>A0A835LBH6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="13382" checksum="A5B88D75751E4D62" modified="2021-09-29" version="1">MSRVYMKYTPGVLNGKLVDPPQIRYNGAQIKTRNIVERTFGIWKRRIPCLSKGPGNKLETVSLIIVACAVLHNLSLILNDNMALGIDSHSDQENGANETSVMASSSAGFVVRVTIIENYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBJ1</accession>
    <name>A0A835LBJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="154"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="416" mass="48211" checksum="B2C8E4757DF5F5F8" modified="2021-09-29" version="1">MLSRRLPRVVKYGLYGSVAIGGTVTAAVKLNDGDYDSLAVVRLSRTAFTAVEIGRTYKSMLYSKEWDRSSQEYLEVKSQAHQIGAEKLLELCKANKGVYIKVGQHVGALDYLLPNEYVKTMRILHKDAPKNSVEELYKVMKQDLKRDPKDLFEEFEPEPLGTASLAQVHKAKLKDGTDVAVKVQHYFVRDNVKMDLKWMEFIIKTMSKVFPDFELQWLIDETKKNIAKELDFLQEGHNAERVADLFKNYKWLKVPKIFWEYSTERVLVMEYVSGGQVNDVKYIDEHKINRFDLCRKLGDLYSHMIFISGFVHSDPHPGNILVKKDPKDKDVTVYLLDHGLYAQLSEKFRYHYSKLWLSIIDRNRDDMRVHAEELGIRKELYGLFACMVTGRPWDSIMKGIGRTRPTSDEAKINIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1I7</accession>
    <name>A0A835G1I7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001018">
        <property type="protein sequence ID" value="KAF9404314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1I7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160105">
        <property type="term" value="F:tRNA (adenine(22)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006901">
        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38451">
        <property type="entry name" value="TRNA (ADENINE(22)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38451:SF1">
        <property type="entry name" value="TRNA (ADENINE(22)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04816">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018637">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26737" checksum="07864E9CCAFE3AE6" modified="2021-09-29" version="1">MNENQLSKRLKRVGEFVPEQSRLADIGSDHAYLPVALVLQSKIPFALAGEVVKGPFESAKKQVRKNGLEQQITVRLADGLDAVEKADEITAVTICGMGGSLIRDILDAGWNKQRLNGTEQLILQPNIGEKTLREWLTVHGYTILEEDILEENNKIYEIIVAARKATRIAYTEKEKLFGPILIQQRSTIFQKKWQRELKQREHILAQLAQAAGDQEARQEQLKREISEIKEVLVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1V1</accession>
    <name>A0A835G1V1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_013351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000629">
        <property type="protein sequence ID" value="KAF9406190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000040">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000765">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9406190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="88252" checksum="6C7291ED1AFF2184" modified="2021-09-29" version="1">MAAPNKPLKFDKICRACLEIKKDMRPLFEQLTATMLMGITKVQVAVGDGLPAQLCLQCVHQISRCHAYKDLVERNDIVLREYAARMQEEVFKREREEKEKLLNMNCQDTYMQYMEVPLTNANQILDGFFAGTPEQTPTNAPEQETKIEFVEVEKAETTSPENQAKDKEGLNSDEENYLQMVLFQATATMPPGRHVCNLCHKEFKHARWLKQHMRSHTNWIKANCKKPHLCPICDRVFKGPGMLKMHMRTHEQRPAKQPTCSVCQRTFPSKTLLYRHRQTHFEQKTHLCSVCDKRFFSGYALRSHMARHRGERPYVCTTCNKSFYNPTDLKVHFRLHTGEKPLKCNECNKTFRRHSTLCQHMKKHRGIRNHVCNVCNKSFYEVSKLNAHMRIHTGERPYECQFCDRRFAQKSALIYHSRTHTGEKPYCCKVCSARFTTSSARNNHMLTHTGNKKFVCTICMKGCTSRSELRVHTSKHTGDKLFPCDQCGQRFSSASYLAVHRRYHTGEKKYHCPVCGKGYVESSSYKKHVKSHGAAAAKSESSSSASEPPEHPEPAVERPADIPPPMAEESTEEQNQGQVEIQVHEPQQVTPRGRSLQKLFRFKCAFCPKTYMYLHNLKKHTAVHSEVQQQVAAQQVLQVGGVPPLALHAQGIVQPLQTQHPYPVISSVQSLQLQQSQQVNAQQPQQLQVQTIQIHPQHQPIQIHAVGVQQVQQQQLHVATSSCQTMLPNILQLQPATVAVSGLSQQELGGVTHRIILQPQPSAGHPAVYTIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3B8</accession>
    <name>A0A835G3B8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000661">
        <property type="protein sequence ID" value="KAF9405934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3B8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="319" mass="34378" checksum="0C9988DEB95D695A" modified="2021-09-29" version="1">MYLKIYKSPCMVQGDTEELFPNRFRIRGQCSELHMWAQQNSFCNTVSRVRYLQLINPVISRTTIAILDLMFVEFVKQATYSRVECSLTEDRVSLLLAEGMWDRARRRTTSCSRSQRPPPPRSRSSIVERRIGLAARRDGASSAPAAGAAGVGARGGGAAPAVAGPLAAAAAGAGARRALGAALRGQAPGSRRQAQGRLRVLGSVLTPTPSLRPQADTVSLRATQPGPKLFSYHDVDDAELAAAGRGCSAREMEDAVALHDALQALHAGHKVPGPLHPCSTTLRLPPCSTTLPLQTSSSRRSRRSRPRHWLDAQASETDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G520</accession>
    <name>A0A835G520_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor, arginine/serine-rich 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000359">
        <property type="protein sequence ID" value="KAF9408821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16983">
        <property type="entry name" value="CID_SCAF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12227">
        <property type="entry name" value="RRM_SCAF4_SCAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000004">
        <property type="entry name" value="splicing factor, arginine/serine-rich 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1344" mass="147165" checksum="B948FD1B44BA0FA1" modified="2021-09-29" version="1">MGSHCSIAPTASDLPTTVSFATPKYFPYPDFKANLFSPAGNAVKISSGEGPSPSPCGAPRLSALYDNKPPISKAKMSAITRGAIKAIKFYKHVVHSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQDKDVFAPRFAKNMQQTFANLFRCPPEDKRNIIRVLNLWQKNNVFSPQVIQPLLDMADPNHPLHQEIQQQQNNTANGSSLNISHNATDSKISPVPQPLHTPQSSTPMGDQFQDQPSSQPAKFNRKLLNDFEYESEDDAAPEPAPQHSSHSTHTSHSIHTAHSATHAQQNPADALGSILTNPEIMRQLQSLQAQMQMMTGMQIPNLMPMMSDLQMQQSQNQGLPFMGSQSDSQKQNDPKDDMVESDIEFVETGPQVIEIPDANDSRDKDRDRDKEKNYKEREAEREKQREREKKGLPPIKKENLSVCSTTLWVGHLSKLATPEELSDLFGAIGGVAAIDVVAPRGCAFVVMERRRDAAKAIAKLNRHKLHSKEITVAWAPGKGVKGREWKDYWEAELGVSYLPWAALQARWALAALSLDALEDGGAVDEDTLPPWLPPRILPKTMMDNMSMLGMPGTAPGLPLGTLGTLPGSLPPVSMPPVSMPPTLSLPPNLPPGANPAISIPRMPPPGMSAGMPPGLAPGIPPGIRPPTLPNMAAGVPAAGYVVGLQNEAGLAPGAPLLRFPPGVPPQSLAQTGMVGGFLSSLLGVGGLLPGVPILHPALHDAGHARSGEATQSDDAMDLDPEDSHAEETAADTTDTSAPPPALLPDQIQALLSKPPPNFNSAEPPPGFNIDQGGSREKSPRPPANNENPEKSLQERLWEMANGKPAREDKREDFPEQRDREDGREDQRTDRPPLIDRLPARLDGPPPAMDTGPWMDGPGPGPFGPRFNGMGPPFNRPPFDGPRPPFDGGPPMFEGGPRFERPPFGRMPFDGMNRPPFDGPRPPFDGPRPPFDGPRPPFDGARPFEPPFEGDRPPFDGPPRFDGPPEFFDHRRRDRRQPRDHEDNRYNRPDRGDRRRNFDDQGRPGDQRRGDDNQNKTNDSRRTDETQQNKSADSRRGDDQSRREDSQSKSRPPKDERNDKNDRNSSRRDRDRKSRWGAAEEAETTGNGDSDKPQEADGANTQPAGDLAASAEPSEVADTTSQDEQTLRTEVSDSIPSQETESEKAFQPPEDSMDSNDTPGLTERSVEPSPGELDEKMEHSLPEPSPPEQSLPEPSPIERSPPECSPPETSIPERSPPESSPPPAEERAQEQTANALYDTDEAVDTNFSAPATTEYEREREPSPPPPVVEKDFEESGIEASKPVDMFSPELEQSESSQEADVSEPQSAESKEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G527</accession>
    <name>A0A835G527_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000449">
        <property type="protein sequence ID" value="KAF9407648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G527"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="29662" checksum="FB36EEB63D24D638" modified="2021-09-29" version="1">MPRNYSRKTDRQGWDKTSMEKAIEAVNNNEMGWLLASKVFNVPQSTLRRHALKQNKFLAPTTKEPEGDSTAAENLCIPSSGPSQVEAGSSTSLIIASTSAADNPLPLSVAQSRDTATAIPTTPTSSKLILQDMNINVPVSVLSPVPIGTYVAGQGKRKPRKKPTILVLTSTPNIEEAKAKSAPPPVPKKNTRKVTKALDFSSDSENDFSSIQGFTEVGDDDEDCPCIYCNDLYSRSKPKEVWLMCLSCKRWAHASCADVPKNTKRFTCELCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5H8</accession>
    <name>A0A835G5H8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000602">
        <property type="protein sequence ID" value="KAF9406375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5H8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="377" mass="43177" checksum="D7622C140742B502" modified="2021-09-29" version="1">MFVVMTIVDLSKTLISLMLEAQQRVERYGTSDVITVETINGWAELYQELVNCCDKVAVCFGYQYTFALSCSTVHYIILVYYVIYYNVYTTREYESTFKLLLLIIGYMIVVILPVVATQMASDQWAKCQRVMARLHNTMIDDAGAAERRLVKQFIRVIKKHPLQIRFMSKMPAGIFLLPALLTVVINNVIIICWCSRKEVGKAIFTCDQEASATDQVYVQDASWHFLTASLTHCVATQMASDQWAKCQRVMARLHNTMIDDAGAAERRLVKQFIRVIKKHQLQIRFMSKMPAGIFLLPALLTVWAKCQRVMARLHNTMIDDAGAAERRLVKQFIRVIKKRPLQIRFMTKVPAGIFLLPALLTVVVDNVIILLQFNHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6E5</accession>
    <name>A0A835G6E5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nose resistant to fluoxetine protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000370">
        <property type="protein sequence ID" value="KAF9408649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6E5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032494160" description="Nose resistant to fluoxetine protein 6" evidence="3">
        <location>
            <begin position="18"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="4">
        <location>
            <begin position="266"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="77546" checksum="D914EA5CB31CDFCA" modified="2021-09-29" version="1">MFLLFLIFILFSGPVYPQATNKTQADTFLDSWAQKLKLEKWKKDEVPCLESVLNVLENVKNHTLWATWILNANALPSGNLYGSFAHYANYDQCLKPPWLHTHPELKTKYCLTEVLLSDISSMKKTPDYDPYGPVVEFIDSPTASGMPVNQIMWGLCIPAACSPPAVSKLTRVVYEAATFSSIASDVTVKHCQEAGETLPYSTGFYIFIAMIFSLVTIAVASTYYRMHLSPEDQTSNSLITIITKSFCMIKNQEDLLQDNKDEIHVMNGIKFLTAANVVSVHVLFYMALSGISNARDYDMAIEGIGGLLLHIDIIVDTFFAISGLLHIKGLMGRRQNLLSVLWKRYIRLIGPFAVIIFYLISVSKHTASGPGWYLGVEEETNVCAESWPKSLLMINTDIKYICHAVTWYVPCDYQLAILGTLLFYFYQKNRRLGFAIFAVVAVFSMVIPGVLTYWFRLPVVHFLDVGKILREIRDAWDVTYTYTSPYSRASSYLVGGAMGYIMAMYKPADYRKSVSTTWSIFGIATSLGAMLVVLSLGYITKYREYYPLEAAVLVATNRIVWAAAICCIIGMCEYGTVPIIPNILGWSVFTPLSRLSYGIYMIHPIIVQRHKFALRSPHKFDVYGLILDTTSTLVISIVLSYAMWLFVEAPLINITNQLFFNKSKDSHSVKSSRENGIQHHNGVSKTKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6K4</accession>
    <name>A0A835G6K4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6K4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="31114" checksum="FBC2E576218FD3CC" modified="2021-09-29" version="1">MEEKQVMKDMEENIKEAINKNIDEKFDRIETKTIELEKKIEEQQKTIQFLDKQVRRKNIVFFGVPESEINYESLLNYILDIINKKMNIVCPKWEIEAVIRLGKNKDKIRPVIVTTTTVSRKLQLLKNKKTLENTGIYIKEDFSPAVLQKRRELQDELQKKRSSGEKVMLRYDKIVKIKSKVHRNDFFKKTSSSKILQMESPENTISFKTSNNEDETVVPREINASKRFLSESPEMRSNENPSLNVEQTKQIRNSSIKIRIMGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G714</accession>
    <name>A0A835G714_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA-directed RNA polymerase III subunit rpc8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_011831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000378">
        <property type="protein sequence ID" value="KAF9408521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G714"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000130">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="15">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9408521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="24099" checksum="3EF3988C8D6A0623" modified="2021-09-29" version="1">MFVLAEMKDVIRITPEHFHQSLTESITTLLNRKLTNKVVLNVGLCIALYDIIDIGNSYIFPGDGSSHTEVKFRFIVFRPVVEEILIGKIKNCSREGVHVTLGFFDDIVIPVNALQHPSRFDETDQAWVWEYPKEDGEKHDLFMDSGESIRFRITSETFEESLPTGPPGTECTIQTVAPYRIVGGINEPGLGLLTWWEAPEQDDGDENDEENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7J9</accession>
    <name>A0A835G7J9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000312">
        <property type="protein sequence ID" value="KAF9409520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="488"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1839" mass="202199" checksum="1C0F2885DE794200" modified="2021-09-29" version="1" fragment="single">VPVQSRHRRAHCSYAPVPDGSFSCTRRGLLKLSRKLASLLSFNSQRISAVGRSSVALGRGRLGAAGAGGRRARRPALHGDARVVRVRLAARRLVQDGLRQLRERSVDVNVGLRRCLHEPDAVLARYLQHTKHSQTINITNSVRVACEYVNPMTPATPMTDYGGQSVHEPETPNVNYSGFNVGAVVNSTVNEPPREEAEESHHEEEEPRSPSPTPTKRVTRSRGRRGDGGFVGRLAESPPPPPLRRRGRGGRGRGRGRGTAPPPAYSPPPVLLPGDDENSLYNILRFNKTAINQVVDMWIEEYKTNREAALVQLMQFFINASGCRGKVTPDMAQMDHTLIIKKMTQEFDEESGEYPLIMTGQTWKKFRSNFCEFIQTLVKMCQYSIIYDQYLMDNIISLLTGLSDSQVRAFRHTATLAVMKLMTALVDVALLTSVNCDNCLRQYEAERLKARDKRANERLEVLVAKRQELEENMEEIKNMLSYMFKSVFVHRYRDTLPDIRAITMAEIGIWMEKFPAHFLDDLYLKYIGWTLHDKVGEVRLRCLQALQPLYECEELKGKLELFTSKFKDRIVSMTLDKETEVAVHAVKLVIAILKCRMHPDVLTDKDCENVYELVYSSEEPPPPARSRRGKLRLPNTPLIRDLVQFFIESELHEHGAYLVDSLIESNPMMKDWECMTDLLLEEAGPNEEALDNRQESSLIELMVCCVRQASTGEPPVGRGPSRKHHHMLSKDQAKMVSDDRARMTAHFMVTLPALLDKFGADPEKLANLVAIPQYFDLELYTTQRQEGNLALLLGKLRDVVRVQTEADVLETAARTLELLCREHCAVYSRCNVARATVTDMCVNRYKEAIDDYRSLIEGGETPDADELFNVINSLRKVSIMYMCHNLNDTNIWDSLFEDLPKCVKENESQMPPQALVYVVRACYYSLLWALHGAGARGRGRGGTDACALVYVVRACYYSLLWALHGAGARGRGRGGTDACVRRRWCTWCGRATTPCCGRCTGRGRGGAGGAVLTRVCAGAGVRGAGVLLLPAALVYVVRACYYSLLWALHGAGARGRGRGGTDACVRRRWCTWCGRATTPCCGRCTGRGRGGAGGAVLTRVCAGAGVRGAGVLLLPAALVYVVRACYYSLLWALHGAGARGRGRGGTDACVRRRWCTWCGRATTPCCGRCTGRGRGGAGGAVLTRVCAGAGVRGAGVLLLPAALVYVVRACYYSLLWALHGAGARGRGRGGTDACVRRRWCTWCGRATTPCCGRCTGRGRGGAGGAVLTRVCAGAGVRGAGVLLLPAALVYVVRACYYSLLWALHGAGARGRGRGGTDACVRRRWCTWCGRATTPCCGRCTGRGRGGAGGAVLTRVCAGAGVRGAGVLLLPAALVYVVRACYYSLLWALHGAGARGRGRGGTDACVRRRWCTWCGRATTPCCGRCTGRGRGGAGGAVLTRVCAGAGVRGAGVLLLPAALVYVVRACYYSLLWALHGVETRPEPGAAALLRERLQGYAAHCKDIVARGITPELKEEAYTSLCDLLILFAEHLVTLHHPGDPEMRQLVFEPDAELCDMLNAFIQEFVFVQHNYDGQDERRIEELHKRRNFLAAYCKLIVYNVAPIRRAADVFKHYIKCYNDYGDIIKATLSKAREINKLNCALTMELAMQALFNDMLQKHAGTPPHRQLPEMLELKVRRGPYCSAAPTAARPLLQRGPYCRARPLLQRGLLQELAKRFSVMFGLDAVKNREALTALHRAGIAFAALEQAGGSGPPPRLLFLEALAEFSGKLLRQDKRHEVRTRMKRATTTWSLTRSNRGECDGGTLRVAALSARCLVVPHSLSTAALRGGGGVHFVNSFPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7S5</accession>
    <name>A0A835G7S5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000405">
        <property type="protein sequence ID" value="KAF9408139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7S5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032298513" evidence="1">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="124" mass="14788" checksum="DE6EE13C8DE4C534" modified="2021-09-29" version="1">MQLLIISAIYIMVIESRLVPTTKRRMIRRNNDPVLPKVFFDRGQSLSPSFKIPNQEFCSGMSLKPEDHYKVLPWWYHYCQDLRENLVKNKQGKDHFSAAHLYILNELQAYKKRMKAKQLKKMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G804</accession>
    <name>A0A835G804_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G804"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40814" checksum="9605B9661AF5F1B6" modified="2021-09-29" version="1">MEREKFCSRNVYFIYTCLQIAVLISFSKSMGNPIEIAAPSSLLRYGMPAACKNQTFCFEKGDNYPDDLVEQFLKAIPLQNNLGSRIGFSFRGGDEENGNADCPANTTYVDKPIYYIVDEMGMVRVVIQSPKKFEQIYSTRWCLNPGVITKNTAHFFPESLTFKKVQLRCETSYMDLDFMVLVDDYDQPTYEVVKALGGIPVCYQMPEACIGQSYCFEKGDHYPDDIMQKLNLNFEIQNSIGTRKGSDVDEPDCPSNSTDSPIYYIVDKNDIIRVVVQIPDKFPQRFNVRWCLNEGKINSDTKHFMASTTLKKYDVECVSSKLEFDFIVLSLESDDKIEIATTNLPVCCKCRYELKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G879</accession>
    <name>A0A835G879_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U3 small nucleolar RNA-associated protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000227">
        <property type="protein sequence ID" value="KAF9411362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G879"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="7">
        <location>
            <begin position="292"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="67002" checksum="FE7929597EF42F91" modified="2021-09-29" version="1">MAEQVNQRIEDMINELEQMRRTQMYDDEEIKEISRKRKEFEYHIQRRVKQKEDFVQYIAYELALLEDISLRRQQAKLSEKKKDIEYAIAKRVNKVFKQFIYRFQDDLEIYFEYIKFCQSVGFDYAISGIIGQMLQIHGDKPKIWQLASKWESKEQNNLDNARNFLLKGVHRHPESEILYLELFDIELIDLTFKTGDEEDREKQVKRADIVWKNGAKNIKSPKFLFNVFDLCRKYEIKESFVDDIKKEIWLRNDSKDVWSYIAAKELEGCHWEEIEEFVDEENNFSKEVNNYIGVYEEALQKFPDETLCTKYIHDLLGASETVCSDQQKISAVKHAWKYGYENGLLTNEMFAFGLEILKLENETSDEELMEILDSAIIMNPKLRCVWEEKILLCKSDEKKMLSVLQAVKGLKSDDLLHIYNVVLDNVETDVALKNLYKKFQSCENAVLLAIKPKLLQKMYEKNGLKAARDLYEDLIRTPPTQIEVHTNMIDIEMLQEKPNPKYIRKCYECAVQHHGTDNVDLWVKYMEFETDHNAQATPAIYRRAVGTLKKEHVDQFIRAQTLAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8G0</accession>
    <name>A0A835G8G0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8G0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="308" mass="35765" checksum="6857C7580785FACE" modified="2021-09-29" version="1">MEMETDPLEGSSYEVGVTVKAEIKEESEDDHFNTMALLELAQCVQTNQEPIEFNSTDAMMDPKTGLMICLHCLEDFDPNLLSDHMVNAHNYRRVLFKCQICQSTFQERKMLNVHRQECQPEQKVRKRKTFQQILRDVEAKYYMADEQALLEPVSCPICLLELPKYCLKEHLVNEHRKPDVILTCGRCNRNFKSKLTLREHVKLVHEAVEDSEECELCGQKFRSLKYLSNHKRNVHPSGNKIHKCSVCGKVFKSRLCLHQHSKYVHPPESASVECPHCPNKIFKSRMNLTQHLKVSHGYKRKISSIPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAE2</accession>
    <name>A0A835GAE2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000264">
        <property type="protein sequence ID" value="KAF9410410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="264"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="491" mass="57375" checksum="781F29D7B5B78BE1" modified="2021-09-29" version="1">MRKLNDKENISDSNMKESSINQSESFEEWLEKLNAKHKAFMENARKSINEMLEKYDSRPKIGADKETPSYRCSSYEDSCLEFGGKFNKTESTSNRMTVDPHPGQMAGNTFNKNNEEVLKSHKEPCKDWHIAHKLISEKSSAIDSNENVVLQLKNKEKPTSFNHPSCSESQFKFDSKYKKIQKSKENHAPQKSTIATKENNERKNPKKSIIKSIELKHELTIPNNGKENQRLAGLPDLTPEQDNLVDTALKLTPADKVLIGKYKINIFKEDLETLSRDKWLNDKIINFYMNLIMQRSKERKDLPKLYATNTFFYHKLKCSGYNGVKSWTKEVIKLLLQFYQFWIFGHTTLRVIHFGYKHTKYVDIFAYDVVVVPVYLENHWCVSFINFRTRKIEYLDSRGQKNDSHTCLDALLQYLKNERQDRKGVPFDDSGWETIVREDIPQQRNNYDCGIFMCTFVEFSSRNAAYTFTQAHMPYLRRKAALEILTGKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAF2</accession>
    <name>A0A835GAF2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000214">
        <property type="protein sequence ID" value="KAF9411747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAF2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27305" checksum="80748DF2E86227B5" modified="2021-09-29" version="1">MTNRPSYAQLEGLVEFLEQNPGIAKGLLRTTQAKLETKRKWATLATSLNSLGGANKDSQGWAKYWAEKKCALKKQCAQLSSSMRLTGGGTASNLPTLSALDQRLVAVMGGHEFGNRDSRLAVDPFPELTIPTSPIIEMPVIETPVTEDTSPVPGTSHDDTPQPICLIPPATPTPTPVHSHHTTTVTIPQPRRRRSLIPRAQNADMEQFARIEERRVEAEMKTAEALAKIAEHMGTIGCALLEISRKMPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAX1</accession>
    <name>A0A835GAX1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAX1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033024243" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="105" mass="11484" checksum="A999FB829E32EAB9" modified="2021-09-29" version="1">MKITLLLLAVCLAVCLASAANINSDRRHILINKPKVDEFGPRNKRSPWPWARPGGGVKGYRPAEAPPSELQMKVRKGEYVCGNRICKLQPGVEPAGCNGICQYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAY7</accession>
    <name>A0A835GAY7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">28S ribosomal protein S21, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_007193</name>
        <name evidence="4" type="ORF">HW555_009566</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000216">
        <property type="protein sequence ID" value="KAF9411700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000201">
        <property type="protein sequence ID" value="KAH9642073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAY7"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="Ribosomal_bS21_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9642073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11673" checksum="EC09BE5697A80875" modified="2021-09-29" version="1">MFLTLRLLSNRHPSFIARTVFVKNNNVDDACRLVNRILGKEGILEQYRLTRYYEKPYQTRRRVNHERCKAIYNEDMERKIQFVLRKNRHEPFPGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAZ7</accession>
    <name>A0A835GAZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinesin-like protein KIF13A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_008360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22706">
        <property type="entry name" value="FHA_KIF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000002">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="45"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="13">
        <location>
            <begin position="1651"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1295"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1352"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1492"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1675"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1402"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1295"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1356"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1492"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1506"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1537"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1550"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1580"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1688"/>
            <end position="1697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1697" mass="188757" checksum="06A5F585D90DB47A" modified="2021-09-29" version="1">MPKMKRDVTNISHQIEFRYRTTERRKQPSPQGDWLPTPHDYVAMDIDNLMTEGNKSRTVAATNMNSESSRSHAVFSVVLTQTLTDAATGVSGEKVARLSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSSGTKNKDKFVPYRDSVLTWLLKDNLRREQQDCYDNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRQEVETLKEMLKYATGSPVGEEVHEKLAQSEHLMKEMSRTWEEKLVETGRIQSERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLVGGSSSADIQLSGLGIQPEHCQLLVEGGGLHMEPLGAARCFVNGTPVVSRVRLGHADRILWGNHHFFRVNCPKATEQDSGYSTATASEPQTPAQPIDYNFARDEIMLNELSNDPIQTAISRLEKQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYPPYAYDPLKLAARVERWAAERDDTFKRSLGRLKADILRANALVQEANFLAEEMRRNTRFSRGAFVSEPAIMVRRPGRSGQVWSMEKLDNKLVDMRDMYDDWRRRQQRGDEVIEEVRLPSGDGEQTETAIDPFYESQENHNLIGVANVFLEALFHDVTLDYHTPIISQQGEVAGRLQVEISRVAGQFPQDRICEAASDSSGDHPSINKAGDGVAAVAVPLRVLSVLAGGGGARRGPARRVGGHAPRRAPAPPLSPRHQSLVTFRFDHKKDFTIPLTEEFIEHCAEGALSIEVWGHRSAGFSRARGNWEVEQQQLAKARSLADRWTELTRKIELWVEIHELNDNGEYAPVEVVQRNDVWTGGVYQVRQGQQRRIAVRVRPALNSGTLPLVCQQILSIEVGSVSVRSRLQMPLDSYQDEDLAVLRERWSDALFRRRQHLHAQLQKLVNMSPSMKSERDNEREQSLVEQWVSLTEERNAVLVPSPGSPIPGAPAAWVPPLGMEHHIPVLFLDLNADDLTTHPSGEEVTVAGLHSILPKEHGNKFYELQILHHHDKDVSAVASWDSSIHDSQYLNRITEANERVYLILKTTVRLSHPAPMDLILRKRLGLNIYKRQSLTDRIRKKIVSYYVDRTDQLTQTGVTYEVVSNIPKASEELEERESLAQIAATGEEASAADGETYIEKYTRGVSAVESILTLDRLRQSVAVKELEQARGQPITMRKTASVPNFSQLMRLDSSFESLAGLASGRAGSMADLAEDTPRRSVHRHSYAAPSHNDPEIPTPTKPFGLARPTFLNLNLNLNSLRLQTPNKSSPASGKLGLRMTTLHEEPGRRNDEDSHSEPESAPVDELTTPRAHATAQHPRGFLPTSKTLDSLHELACERVPNKNSPSISSSGYGSQAVSSTNLTNDDTLSIRSMSVDETPDFDKTMDYTHISRTKNSMAGLRNEITELRNDINDLKNDIVESKHELDDSMFEKAKTPVLTPGSRNRINPFLRDCEDAVKDESKNQMVDPLGALPVESAVLSSSKSVENSQVNGDVTHDSANDVSHDNSQDTSFGEAEIESVSSEQSSHDAERSREASSVGESDSASTGPDQPVVKTQLPAGKVVRRRAGGSARNASRASFPSARPRSAHEPGLHHTPASSTERIGDEEPSECGVVQAWMCVGESVQLRLSSSTGVIAYAGPTHFAPGTWIGIELDAPTGEGLHNLHRSRSRGDSINAVGTKTRNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB31</accession>
    <name>A0A835GB31_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_014492</name>
        <name evidence="14" type="ORF">HW555_009500</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000212">
        <property type="protein sequence ID" value="KAF9411803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000311">
        <property type="protein sequence ID" value="KAH9639734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB31"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9411803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9639734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="9479" checksum="46E08B134F33FDA1" modified="2021-09-29" version="1">MGKHFGELAKIRGLITYKLSPHEQRAYAGAISNGIPNMFRRFRESVFKVAPPFIIGYLVYEGVEREHKRLARKNPADFENDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBC4</accession>
    <name>A0A835GBC4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="22445" checksum="A7DF88BC95F7C45A" modified="2021-09-29" version="1">MMAFNSPSILRGKDTNPKNLYYKLDDEIQKLLYPFDVTLLLLLSPRYTIKDDYITTIGKKRTAVQCLSLFFIIIITISSTLSFITDLMVHKYPIVNVALFLWVAKDILLFITQSVECEKFYIANEEAMLACIQLMKNKNCPSDQLHLYKQVLRINRNFNKMSACGFFHVNAQSTITVIRILVGYICVFLQFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBY3</accession>
    <name>A0A835GBY3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000223">
        <property type="protein sequence ID" value="KAF9411484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="29797" checksum="208640779C124607" modified="2021-09-29" version="1">MNIACYVCYVNFEQFSGFDALTTAKSTPNGLPKTKPKTGTSENTQTANFTIKSLIPKRTKFKVRKLVQKCLMNKRERPMSIGPYVVPTQLDLVLFTQRTLLKMFRSYHEKTLLLLKDIKEATRATVAVEKTCRGDGKSMYKKCVRQVSKKCVTITKDLGQSLERQQAQVIALTEDTICNITSMKTDPIQLIKVLAMDEASLEFALPAFLRLLGGCNVYCTKETPPDRRPRLRQLTDQELVVRHFLTKKNYVQLIKDTNKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCG6</accession>
    <name>A0A835GCG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09390">
        <property type="entry name" value="LIM2_dLMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="243" mass="26056" checksum="EEB622DFBAD8E31D" modified="2021-09-29" version="1">MRMRILMTSASNDCMSCGQQDDNKYGLTVNSNVSGGTGGARLCAQCGKVITERFLLKAMERFWHEDCLKCGCCDCRLGEVGSKLYYKADLMLCKRDYLRLFGATGNCVACNKVIPAFEMVMRAKSFVYHLECFACQQCNHRFCVGDRFYLCDNKILCEYDYEERLVFASMAANPSGLAHIRRQVSGLQSPTSGGYVAGVAGCGGGAAAGGAMVDKDGGGCAGADDASSGYGSPPDPDVCDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDD8</accession>
    <name>A0A835GDD8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine aminotransferase 1</fullName>
            <ecNumber evidence="12">2.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Glutamate pyruvate transaminase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamic--alanine transaminase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Glutamic--pyruvic transaminase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_008197</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDD8"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000236">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="84"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9413619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="479" mass="52879" checksum="20DCA07CEAF9A388" modified="2021-09-29" version="1">MKLDNSLTADNINQNLLNIEYAVRGPILQRALQIERELTKGVPKPFERVVRANIGDCHALGQKPITFIRQVVALAACPALADAADVPADVKQRAREILSACTKSSVGAYSPSAGLRAVRARAAQYIAARDGGAPASSDDVFLGSGASDLIKSVLTMFVEPVDGKPPAVMIPVPQYPLFSGTLSELGLRRADYFLDEDNDWALQTCELERCWREASEHSHVRALVVINPGNPTGQVLTRENMEEIIKFAYTRNLFLLADEVYQENIVCKPFHSFKKVMHEMGAPYSSMELASFLTCSKGWAAECGLRAGYVELVRLQPRVAAAFSTARAVMQCPSVLGQCILDCVMKPPAPGEPSYPLFAEELGEIQRVLTERAETAYETFNSIPGYFCNPIDGSMFAYPRITIPEAAQAAAKELNMSPDEFYCLRLLEETGVCVVPGTGFGQLPGTFHFRTTILHPRDEFQHMMDSIRRFHLNFLDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEM1</accession>
    <name>A0A835GEM1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="400"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="540"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="861"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1445" mass="164256" checksum="04EB7AEC2E014576" modified="2021-09-29" version="1">MVNNTIAPNAIYKALKRHYDEYFQNDEDDNLYSPRVQSSSSSSPSRHSVASLSLTYQDKYKPAVVVQKELAAKLIKDPNQVCPPVLPSLAALRQIKYEKRQSKRLHAHPILSILMMTICSQRVTLNRVTEERILEETPHLCTPDFANNEILKSVQHLKKDITTQEFPSVPQKYNAMVGKLKDAGIDIITSIPKFSSIKDTLYRTRNSAAQVQKLQHKNVLEVEVPPRYQDFLLAEYTCDDTRILVFSSSEARQTLCELTDFYGDGTFKSCHIPFTQLYSIHGDIGSTINHTNIIPLVYALMSHRNTEAYVILFSIIKSQLPNGNPIIFKVDYEKAAMRAIATVFPSIANANKAIFKKGRELHITYTQDPKKKRMFAVVITGCLVTRKMAATAWTNEKTLEFIEQYKNKPLLWDIVHNDYRNKIKRHDALLELANSFEISKEEVEKKIKNLQTTFSKENKKVKDSLKSGAGRDEIYVSKWYAFQAMMFLQERNRPRSPVSTEDRPHSSMSTDDDTQKSPSVPTWHSQDILENLHLQVLHRIFIECVQQYPCLWDTKLISYKQLDVKDAAWKEILKKTNIESVTQAKLKWKKLRDTHREKLKKIKKTTSGQSQKQIKPWKYMSHMEFLLPYMTNAERDTNVTPHPDISTSFEETANTDVSRDSADTITAPKKRKTDEIIHNDEDLLNFLKDMDDNLAKRTAQRDELRKEVLTSSDPLKAFFDSMYHSTKQMPEYYQRTIKRKLFQLVMDAEDNIANTNYSYTGYYSNDYSYNSRPSTSQTNFSTGHGSASPEPSGSGVQQIGIGEHTTRTNTHCREMTTGCSLGVSSNRLASIAERRHARLPCPATVAGQALSIVWSSEQILTLIELYQNSQILWNTSHSDYKNKIKKNDAWESIATTLNIPRKDVEGKIHNIRSQFLRERKKIASSKSTGSASGDVHKSNWFAYDSLLFLVKGATSSGSMDSMNAQTSESSVAHKEIPAASQVLTQPPEAPTSPPPLPTQPMPLTNTQNKRKKDHLSELRNIKNEYTVLQTKYFINNILLEAKMGKYNYTENAMGSNSSDNQSYQSYGYRSASQQSSYSTNSVNNNIVTANASHVNNDNGASAEPTHIEFRQFENIQELTMLDLFAMGHFLEHWRNIQQSGFLLPERRQLRECRAISICDMSPSENAALSFIALVAQRQTSEASAPWQCEQSAINCLYMHLFCSPGKPWNNFLCLLIVSVKTAKSRWKQLRDNHRDALKRQNATRSGQARKQRKEWKYQKAMSFLLPYMCNRDRSSNFAPLDDSVSETSNPPNTIDESSRESCNLLPSNSNNLPSVDVPNDSTASGPLPSTSKKRNNDEILDLLKKNQKRRELLEQERIEVKNMMSASDKYSPNNYGYSTASSTPTTDNINTSIDIDTPSAPNDINTSINTPSASQIQTTQDIETSAAEQTGPNENADNFETDYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEP6</accession>
    <name>A0A835GEP6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1296" mass="148701" checksum="D3D509BBA88A1A5B" modified="2021-09-29" version="1">MVPNIKKTSVVVLKTIIKILVCLLRVSTRRRQKVFIIFGTIITLGLLPHWIAWIFRKPLGLEETRSIVENRSMEYCLQEKGKGCERPKLDPFSAEVMALTRDMPKVTCDGFDWIVCKKSECYVTQEILNNVTDISCDYRDIMYVNDQEYYLSDSTIIKGGDNLFTPRWEGVKTGLRPVKTYPNPQNHGNSYNVMILAFDSSSHNGFMRKMPKSYKYLSKNAIIMNGYNIVGDGTPAALLPILTGKSEEEHPDARKKITKKVYVDHRSFIFHKLKSFGYQTAYWEDSPHIGTFQYRFNGFQHQPADHYFRAFFLEHNSLSFFTPKYCTGSTPTYELMMNISDELDGKKFCFTIIGDICHDDFEQISTADDFLLSFMESWSSRKVLEDTLLVVMGDHGSRFSKLRETYHGKLEERLPLLSIFLPEKLKRLRPDAVAALNENIERLTTPFDLHTTVLDVLDLKDLSNMYTIPGCNLLRALSLLTPIPASRSCADAGIAQHWCTCTKWQSVDASSPMYNRVANALAEYINSLTSELRSKCEIRQMTFVKSVLRQKVDDQVLKYVNYKEEDAFFGNPQISAPKAPSEYYMATIIMNPGRAVFEGSVVYNTQTYSFTITKSKISRLSPYKNEPHCISATHPHLNPFCYCKDLPRSKTNVEFLKTIKKMLVCLLRVSTRRRQKVFIVFGTIITLGLLPHWITRDIRKPLGLEETRSIVENRSMEYCLQEKGKGCERPKLDPFSAEVMALTRDMPKITCDGFDWIVCKKSECYVTQEILNNVTDISCDYRDIMYVNDQEYYLSNSTIIKGGDNLFTPGWEGVKTGLRPVKTYPNPQNHGNSYNVMILAFDSSSHNGFMRKMPKSYKYLSKNAIIMNGFNIVGDGTPAALFPIFTGKPEEEHPDARKKITKNVYVDHRSFIFYKLKSFGYQTAYWEDSPDIGTFQYRFNGFQHQPADHYFRPFFLEHSSLPFNTPQYCTGSTPTYELMMNISDELFQLDGKKFCFTIIGDICHNDFNQMSTADDFLLSFMESWSSRKVLEDTLLVVMGDHGSRFSKLRETYHGKLEERLPLLSIFLPEKLKRLRPDAVAALNENIERLTTPFDLHTTVLDVLDLKDLSNMYTIPGCNLQRALSLLTPIPASRSCADAGIAQHWCTCTKWQSVDASSPMYNRVANALAEYINSLTSELRSKCENRQMTFVKSVLRQKVDDQVLKYVNYKEEDAFFGNPQMSAPKAPSEYYTATIIMNPGRAIFEGTVVYNTQTYSFTITKSEISRLSPYKNEPHCISATHPHLNPFCYCKDLPRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEV8</accession>
    <name>A0A835GEV8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000168">
        <property type="protein sequence ID" value="KAF9413156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEV8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF17">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="3">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="350" mass="38916" checksum="7CC9207F1074F356" modified="2021-09-29" version="1">MFKYIFTDTASAHIMPSQRVMVRRVTRSSPDSDDTLPGDESEEYRDDAFLVSSNPENNYYVGAGSSGNSSFCSRFFTALGRQLHSMSYLCPGLFPWVDCGPATDLSGMFVIKAVGVMYLLIIAFDMFAAFGSPGTSTFTNVSMLLLLFGIFAILLMISRRPQNRVALIYTTPGLPFVPTIAIIVNIYLILNLSYLTLVRFTIWMAIGLVVYFKYGIINSSMEKKESDETVEVPPTPNPLDRTTIPPPSPHQSRPTGDRNIFEGDGNEGLYGNLEYNSLLTWHESNLQPVASSSGFSTPSSGNRMQTTYNPTTTYRQVETRYDVDTNTTTTALGRPPWAYPDVAVYGNWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEZ0</accession>
    <name>A0A835GEZ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000149">
        <property type="entry name" value="Cyclic nucleotide-gated cation channel beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF1">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL SUBUNIT B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="465"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9413213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="684" mass="78006" checksum="DD6EFE93CB9EB9EA" modified="2021-09-29" version="1">MEIKVDVHTVHPARTDRRPPQPKATWCTPDSTPIHTTLTKTRSNIETKSELQDGQNKDRDLSQLQKVQLFSPSPPPAYKSENDITQADTELKEFKLPSSNDNSPTIPPASEDKLDAIIETPQSPVPSSPSYHQKCQKFAQLSALRDLFVPIDPQGPHYISWLFIMTISYSYNAWCIVLRATFPYQTPSNTSIWMACDYLSDVMYLLDTVFVKPRLMFLHEGFWVDDLAETRKNYRKKSQYKFDVISLLPLDLLYIYFGTNKVILRFPRLLKLQTFWEFHQAIDRVLASPYVVRIGKMLFYIFYLIHLNACAYYAMSDYIGLGSNGWVYDNQGSAYIRCFYFATKTATSIGKNPKPENTIEYLFMTAAWLMGVFVFALLIGQIRDIIATATRTRTEYRKTLDGSRSYLRRLNMPVTLQRRVASWYDYTWSKQRCFDEPRILNSLPSNMKRDVALEVHMTTLSKVQLFRDCTDSLLRDLVLQLRPVCFLPGDVVVRRGEVGHQMYIISSGECCVMSQDEKEVLATLQEGSVFGEISLLGIDGLRRRTATVRARGYASLFALSKSDLDAALKHHKQAAQVLRIRADQIIRENAARQTKQRMIRLEAKKSVSIHEDEGIVRRRLSNTSTSSNLTIEGARRQRSASALSKRRLSAVSESGVVDQNQAATLAVTCDRARTPVPTIVLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF73</accession>
    <name>A0A835GF73_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF73"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="10134" checksum="BC5A105436CA83F2" modified="2021-09-29" version="1">MESPVMAYAYDITPNYSYIFEFENEFIHTDYRKWMTENWTVAFYYVGVYMAFIFGGQYYMQNRPRYVTMSSVPSSVCQWPTHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF75</accession>
    <name>A0A835GF75_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032511868" evidence="1">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="192" mass="21879" checksum="65620A587DB95658" modified="2021-09-29" version="1">MLRQLLLYHLLLCSLVMSQETEKESSSSADDQGEQLITSLRNDANLDLSADEEYEDLRAELLAYNTALASLTPTRRAIKGTECWKRKGICVKMNLCEGLPYLSLVPGCRSNKEVCCLAWNKFIVKDLKHLGIGKRYEFGGGQGIILKWKEKPVDLQKIVDSPVTRVKRNNVHKRENRVSDIPVMIIFRNNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF80</accession>
    <name>A0A835GF80_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000144">
        <property type="protein sequence ID" value="KAF9414049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010629">
        <property type="entry name" value="Ins_allergen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21163:SF0">
        <property type="entry name" value="GH08205P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21163">
        <property type="entry name" value="PROTEIN G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06757">
        <property type="entry name" value="Ins_allergen_rp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="654" mass="75478" checksum="037793F064E08EB9" modified="2021-09-29" version="1">MFIIKHTGAVQSASQNSGNDTRMMKQALVVLALVALAFSAPQSRKLFHEHVEDFLDIIMEEAGHEIEHLNEHYLEYDEFWAALDYIRTNNFKDLVYEMESLPEFVAVIEFLEQDNIDIHYFIDLFNQMIEGIQEVRSARHSTSGRDFTSFIRDCIDAFPKAKLSALFDQKMADDEEFSTAVTNLKSEQWDAVFSALWANPVFQAEVATLAENGIDVKVFLDEIVAIFVSLCIGLVSGFIVPSSVPELANKWNETTTESTSNVTSDTISNTNSSKYSVLPKNRSDIDEKDLYEHATEKQNNQSERAFIYLNQKFRKPARNKIFKLPPVEKIMYGTVVPPALPSIVTPCPMSNKVSLNSYFQGFDLSDKLPQEMASYFADPTVFRCKDNTKNSNHVNKKVPNTTPRKVLPQSPNKMDERREYFELLKPPIVRPMNRNINNKANYESVRQNEFPSLTPSSVMPYKGRYPKKYSLKIPYVLKPKMSPIRNDDISNKKFGFDSSYNRRPFQTKDVNNRVEDVNFERDFINDDNYHRLYENNQEDDKLLDKYLKDTLEEQFTPDCSYRDCILQSAKPYKNAGRLVKPDCKCGRRLNIKQVDPFVVKDRALREEGKHNDTDFKSSSEINYYEEMLSEDLNVIKQDDDVVRPPNKTNDTSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFS9</accession>
    <name>A0A835GFS9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000004">
        <property type="entry name" value="Type II inositol 1,4,5-trisphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031896">
        <property type="entry name" value="INPP5B_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16776">
        <property type="entry name" value="INPP5B_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="514" mass="59581" checksum="11E2EB8EC2D675CC" modified="2021-09-29" version="1">MNHDEIKSVVQEKFLSSERVTAFLCDAKVLHPDWVKKDRLLAIVEFGDEKAVFCLFTSCYPPKSFTDLSIEIVLPIDKSFKCEIDNKPSDPEAILYLNLQSRSNKYKFEIQMTPRVDNFVDDLFRGIEAVNKVPTQPDFVWLKKYTGKIDNDILTHTMAHPGGVPHTQSSAPVAIRESLIKHKMSDKEYEYTFTKKFSIFCGTWNVNDKSPVIPLKDWLSVDREPPDIYAVGFQELDLSKETFLFDQTLREDEWYSAVIKYVDKRAKYVKVEKVRLVGMMLIVLIKEKHLSHVRNVVCDTVGTGIMGKMGNKGGVSIRFDLHSTSLCFVNSHLAAHVEEFERRNQDFRDICNRTRFVQLNQLPKSIKDHDQVYWLGDLNYRITELDPTTVKKLCNENSFAPVLEWDQLKQQHKLNNVFSGYTEGEINFKPTYKYDPGTDNWDSSEKNRAPAWCDRIFWKGDNISQLGYRSHPSLNISDHKPVSAIFNSSIKIIDEEKYRKVYEEVIKQLDKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGR6</accession>
    <name>A0A835GGR6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_001342</name>
        <name evidence="13" type="ORF">HW555_007072</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9634140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGR6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9415196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9634140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="462" mass="50589" checksum="383A0A0D0B993643" modified="2021-09-29" version="1">MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYHEARYEEIKKEVSSYIKKIGYNPATVAFVPISGWHGDNMLEPSDKMPWFKGWTIDRKEGKVEGKCLIEALDAIQPPSRPTEKPLRLPLQDVYKIGGIGTVPVGRVETGILKPGMVVVFAPAAITTEVKSVEMHHEALQEAMPGDNVGFNVKNVSVKELRRGYVAGDSKNAPPKGAADFTAQVIVLNHPGQISNGYTPVLDCHTAHIACKFAEIKEKCDRRTGKTTEVDPKSIKSGDAAIVTLVPTKALCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVTFKEVTTGKITKAAEKAQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGY8</accession>
    <name>A0A835GGY8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000084">
        <property type="protein sequence ID" value="KAF9416762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8429" checksum="3A178F8CE20E4AEE" modified="2021-09-29" version="1">MRRDCLKLRLSDPSPGSLSFHASDSEEESSDRGSRSSRSGMEEPHVLPITVTAAQVNKVAEFLSMDIYLFIMALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH83</accession>
    <name>A0A835GH83_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_013092</name>
        <name evidence="3" type="ORF">HW555_006789</name>
        <name evidence="2" type="ORF">HW555_007190</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000693">
        <property type="protein sequence ID" value="KAH9632720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH83"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9632720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="228" mass="25649" checksum="12A553F48B921370" modified="2021-09-29" version="1">MKIWTSEHTFNHPWETVAQAAWRKYPNPMNPAVIGTDVIERKVVDGVLVTHRLVSSKWFFPKWAQALIGTAKICYASEKSEVNPNERQMTLKTTNLTFCRYIAVDETVRYTPHPSDTSKTLLTQEAVVTVQGVPLSSYMEDLLTNKISLNAGKGRQAIEWVIGKIDSEIKELASTACKSTDELLSHTKKSLDDITSTARRSMDDISSKAKRSLDDIEKFTKANANQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHF4</accession>
    <name>A0A835GHF4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Slowpoke-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53555" checksum="9D5FA7CC821030D1" modified="2021-09-29" version="1" fragment="single">KIVHIKKISQDVQLIPAYESEQRGKEQKEPETTGHDRFYQERPRSSYRKKKRRGACRRAQSAAELNPESIAAANKRNAFRIRSVSTDREESEEENSERAPLVAQKIDSLAKLLFNKSLIGTGSGKSSPSEPPASPRAGDRSMESSAALAICTEYLSQSPRYDLLSALGSIGSRLNKHWFAIHDNSIKTDRLLTLMPLTSKCPIEQGERSKTLIMELFRALHHPYIYPVLDLELCNGHALTVLPFNARGSLKDLIYKSTWNDDYARKYGTLGTGLPAWQVARFGRQMLEGLLFLKEKGFPPFRHLHSGNVVVQNGVARICGLENTLIGAQPRCPIALAAQLEHVEALSLGHVLFEMCAGTEIDLALLPDLLPNYPNVVEIIEQIFGPRTPTLHELLLCELFRKIDLREMKGSCLPNFSQRLSRSCLSLLGEVARRTPGSPRTRTPPRRSVPASPASPATPTHRRRHFPADQDFTEESQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHP0</accession>
    <name>A0A835GHP0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="8410" checksum="F31B75865AC578EC" modified="2021-09-29" version="1" fragment="single">PADSPRDLIESAMAATVAAGAGAALGSSSPTRHESRAHRDNWSTGRWPRNKSPSPLPAGSKLPGAGLYSLMWVGPATTLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHV5</accession>
    <name>A0A835GHV5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_006432</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion inner membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="16"/>
    <dbReference type="EMBL" id="JACKWZ010000096">
        <property type="protein sequence ID" value="KAF9416109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHV5"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <keyword evidence="16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="17">
        <location>
            <begin position="38"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="18">
        <location>
            <begin position="486"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9416109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="637" mass="70948" checksum="C3923F1E18A3E98E" modified="2021-09-29" version="1">MIHFARKSCLIAKIIRRQLPTKYFYRNAAYTIHHHMHDVVIIGSGGAGLRVAVGLAEAKFSVALVSKLFPTRSHTTAAQGGMNAALGSMHPDDWKFHFYDTVKGSDWLGDQDSIHFLTKNAPTCVIELENMGMPFSRTKEGKIYQRSFGGGTINFGKSVAKRTCAVADRTGHALLHTLYGYCTQYKNIDPFYEFFVLDLLVQNGEVVGCLAMDMDDGSLHRFQAKNTVITTGGYPRMYFSCTAAHTCTGDGTAMATRAGIPLQDMEFIQFHPTGMYGSGCLMTEGSRGEGGYLVNSEGKRFMEKYAPKAKDLASRDVVSRSMATEIRQGRGVGPKKDHVYLQLHHLPAELIREKLPGISESAFTFTGADVYTQPVPVLPTVHYTMGGVPINYKGEVLIYQGGKDCTVPGLYAAGEVVSNAHGANRLGANSILDVVVFGKSIADTISQNFKPGDKQMTLKDNLCDCSLDNLEKVKNANGCAPVHELREAMRQTMQAKCGVFREAKLLDEADVEIQKWYKAFEDIRVTDKRTNWNTDLIETLELQNMLQCAVQVVACAKNRKESRGAHFRDDFPKRIDEFDYSKPTEGQTKKPFEEHWRKHSLSTIDLNTGKVNITFRPVIDKTMNDEVKWIPPVPRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIB5</accession>
    <name>A0A835GIB5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIB5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="542" mass="62258" checksum="E85D7B9D48CBA0F3" modified="2021-09-29" version="1">MAQELKELCQLLFPDSAEENAEYFSEITDYIKKLGSQNWDHIRKEPERLNEEMKQLTEQTQELAFTNYKTFVETAEISHTIINDLAKSKESLSSFLDNTPIFLQECDKFSQVAGNIIKEKSRYSTIRNQSDKLLELLELPSLMREALNAEDYESALDIFTFVRNLSKRYSEIPVVQNTTSEIMTLWFETLYHLFNQLRYDLPLPQCLQILGYLRRANTVYRSTDEDESSLYSGSNKNTVSADGLHVHFLKARNAWFEKALEDAKNTEELHRIHLFNVLTQHKSIFLSDSQEAKIRDDELSGTSALSCWLKLKVETLAKILNQDLPKEDEASFESLLNQCMYLCLSFGRVGADMRCVLTPLFRNNILMQFHSGLEKADNLFETQMRSYKVPSIKNVPRPINESATTGPPENLLDYYPLAEYCNGMLSVLNSMRVTAPLNIVKEVYNAFRESFNKAVQVLLTFYYREQQSFTDIEKQNFVSLCVCFTEDLVPYIGKCLAQSFPSTQVAELLGVTLTVLQESNILHIDQNAVCEPLNFITGVVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GII1</accession>
    <name>A0A835GII1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GII1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="688"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="105935" checksum="032F202DAEDCAFCE" modified="2021-09-29" version="1">MSTESEENGIHIESVDVSEKVKENGLSVGENICDSGLDTLDTSSAAFPASDSDISPIKNITSDDLGHGSSTGSLSHENSLSSSGSEDGATDNLNFELPQQTHTDFAKELIINCIDGINISEPEEKCNEHQQINDLKQQECYDKGNRNLTTSTVSLDDNQCTDNNIISKSPFSRSAENITNITIDNKNEKTCLNSSDKELNADKILSQFSSQKTKASAVQKIPENVNNTDPRYTRIPKELLSQDIGSIVKNVHGIFSSVSGSLKSAYTHRTVYAQKPPKTTKNLPNGKLMNDIFEDENTNTKTDMTEKPETMDCKENIPNCKTPIPNSVDLVLKPTDSDNLDTSDAKKDVLRLQIESLERVLAEQRKENASLRDRVKQQCDELQQKDLTFKELEVKLDMMGKRVDHAEREKDAAVMRYASVECAAIEAKRAAENAAKAEKAAQAEVELLNGKLKSAAAEKHRICQLYDDKCHELMVSERELAKVREDIRELDGRLKWTQSKLRVEMDAYKEALEKSEKLAQQVTELEGARETAVANATDSARAKQLETELKESRAALILCRHERDELERKLTTLTQQLDTCTKERDTATASLARATAEVEKLKESNLRLEEEAAELAALRAKAALADTLSAQLQRESERASQAEEALAVERGVAETCGRREAAALEHAASLTAAHVALSAAHSRRDAEARALTVDNASLREQVASLEIECARLQTALTEETERRNKENRVLARKVAELTEEVSEANKKLEWEKGENNVLKKKHASAIKELNRELQRAVKRCEQLEAKLPQHGESAPHEERLQNGHSDTLPDIQVREPDRQTLIERIVSLQRAAARRAERCDFLEEHSRQLTAELRTKARLLRHLLCELPAGAVGSSRRDDNKKEIARLGGGAMAAVWGGDPGGITAELSLEMNRRLQAVLEDTLLKNITLKENMDTLGAEISRLKEQLKTQENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIR0</accession>
    <name>A0A835GIR0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Extracellular superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_005631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIR0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000004">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="12">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9417229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="279" mass="29757" checksum="A40FB1AEE7063FDA" modified="2021-09-29" version="1">MEVLVDFGPKPDEVILNKTLAELKSQDGVKDAVYKEGAILVETALPSTQILEMVTKTSGKRAVLQGFGDTQSAVAMISSQSCCKRQVLGVIRFQQTEEGALVADGSIDGLPAGMHGVHVHTAGDLSQGCKSIGEHYNPCGAPHGAPEDPMDRRHAGDLGNIVADETGRATFRIVDNVLKVWDIIGRSVAVTERKDDLGRGSSPSSKIDGDSGTPIACGIIARSAGVFQNPKRICACDGVVVWDEKDRPLAGKGRREEKPKRRCCENHNNSSVVNPCCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ97</accession>
    <name>A0A835GJ97_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ97"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000009">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="208"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="393" mass="44937" checksum="9F29EC11A8D3A167" modified="2021-09-29" version="1" fragment="single">MGQINSYSVTEMTMVAVLFIVPIVTFYHSYQPEYDKNGVLSDTFWKTPQRAIPGRPLQTVKRTEVMSGSSYQQFQASVNDAWDMGDDDIISGIAETKISKAISQTAALNVINSHRNSSRNVKNNDVKVESEIVKPKAEAVEVKKNEVRKLGAGGSGPMRHYPGRPRPVRLSALTSREESSESKLERFQQMHDSAVIDLNELKQISWSGIPVKARAITWRLLAGYLPPNAERRAETLERKRADYKHLVRQYYDAERDDDTYRQIHIDIPRMSPLVALFQQITVQVMFERILYIWAIRHPASGYVQGINDLVTPFFMVFLQEAAPGQELDNFPLDKLTEEQRDIIEADSFWCLSKFLDSIQDNYIFAQLGIQYKLDIGSYKEDKQKLDQYAIGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJW2</accession>
    <name>A0A835GJW2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJW2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF54">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transferrin-like" evidence="1">
        <location>
            <begin position="65"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="1">
        <location>
            <begin position="400"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="728" mass="81863" checksum="79D984815371B9E6" modified="2021-09-29" version="1">MNFDRRIHFTNLDACTLLNYLQSTYKTADAAHYNCSRRPLPPTRVDGCSYLCRWEHAALLFSFTVRLCIVEGRGLYKRAPTHCPILDKEKAGVECVLGTDRLDCLRRISKGTVDFGVFFPEDLVAAQWANIDVLVTNELRFRSRPFARNIVAVVNRRILPDDSSTLHAVLKNSTLCHPGESMDDLRPLSETLSAYLETLVLERSCDPTRSHTENRLKALADFYGKACKAGPWVPDRTRDAELKRQYPSLCAACAKTCMAGDIYWGNSGSLTCLTDGAGDVTWGEADDVRTYFKIKEGEPLTGYENFAYLCRDGTWRDLTQEPCIWLRKPWNVIVAKRKASEAVSKLTQSLTNSSVTVDRHWRGALSALLESNQALPEPLHPPRAPMDYLAQAQGFREAHITFCTISLLAKNKCEWLSEAGAVYGIAPPLQCIMRSSTEECLKAVSNGECDATAADSDWLVAGIRDYALTPILNEITPIVEKTGSIVAYVNKDAEITKMADLRGKRAAFPRYDGVAWHSVKDYIMKHEKMSCKDYVEEYFKEICAPGMDGKKCYEAGEEEALKSLLDDNSDVAFISMKTFNTYKENNKASETIKKIVPLCPEGNQKFCFVSWSNLGHIFVANNITNIRRHEIINVFTKLDQLFGKHPPFHNAMFSMYGPFNHEMEVIFHSNTKSLATINVLSTHPYNKIPYNFELAMSNVTDFTCGFGAKTTPSFFVFLVTLVVFLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJZ8</accession>
    <name>A0A835GJZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10115" checksum="FD6378689B048348" modified="2021-09-29" version="1">MPKSQRNQAVPTKTSLLLTLRYLATGSYLRSAADFCGVSPPTASRIVKKVTEAIAQLRTVIIKFPDNLSTLQDGFYEIASFPRTLEEIAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKX1</accession>
    <name>A0A835GKX1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_005043</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKX1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="341"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="792" mass="88902" checksum="EAE1F8B00A084446" modified="2021-09-29" version="1" fragment="single">DTYATQSQVKDEVGVRCQKLFQDFLDEFKEDNEVKYEKAAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPFLNQAILNYVLSIADSGVKKDLQGKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVLGTFVCLDCQTVIKNVEQQFKYTIPAICRNPVCANRRRFMLDADKSVFVDFQKVRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGSLSLPGAKAELTTRTRQGNDGQMEGIKGLKALGVRELHYKTAFLACSVQAISRRFGTAEMATDDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGILLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVKDEESFDFVIEAGALMLADNGVCCIDEFDKMDIVDQVAIHEAMEQQTISIAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSAPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEETYDCVYSREDLLRYIAFARSFKPIITEEAGKLLVEYYTLESMLRLAEAMAKMHCSGHVTPQHVHEAYRLLNKSIIRVEQPDIHLDEEDPQYEPSMDVDQEIPNGGTEAPVNGDSAPKKKLTLSFEEYKSLSDMLVVFMRKEEVEAETRGEESAGMRKSAVVSWYLEQLVGQGQIENEDELLERKTLVEKVIDRLMYHDQVIIPLSTTGLKASQKSSDQEIEDDPLLVVHPNYVVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLE6</accession>
    <name>A0A835GLE6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="11696" checksum="DD59B42C718D23DE" modified="2021-09-29" version="1">MVTVMILDSAANRINVNIGGDGTTYVVILQCSKQGPIEGILMIYHMLVSVCKSSDRVETTPGHDARAGSHSRTAPERRPTYVYCMEINNWPPYSSFDELSGGSIMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLN9</accession>
    <name>A0A835GLN9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLN9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="225" mass="25769" checksum="77969FF9B8656CEF" modified="2021-09-29" version="1">MSDYIHPCNETSRECLVKATQDAIPEFVKGIPELGVPVLDPFTIEKLSIPLSGLTFTFYDGKVSGFRKCIVDDVISELEKRHFVLAFHCNLTIKGTYDANGRILLFPIDGAGDAKIKLTNLRMKVDIKTKYIKDNKGVNHFAIKNYKYTFDYGDRVAFELDNLFKESKELSKTVLQFLNENWRLVAEEFGKPIVDYAVELAIRTIEKFFIVVPYEELINVPIPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLW6</accession>
    <name>A0A835GLW6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_004758</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion outer membrane</location>
            <topology evidence="1 14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLW6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="419"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9418470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="630" mass="71898" checksum="7E77E1D2A572340F" modified="2021-09-29" version="1">MVYESVPRTVRILLLGEPGVGKTSLILSLVTEEFTEHVPPKAEEITIPADVTPEQVPTNIIDICLAEQTLEQVGEEIERAHVICIVFSVDRQETLNKIASYWLPFVRENCPDDYRKPVILVGNKIDLIDYSIIDNIWDIAEEYPEVDRCIECSAKSLINVSEMFYNAQKAVLHPINPIYNIEEQELTEKCKRALTRIFKICDLDGDGLLDDYEVTMFQRKCFDSPLQLQVLDEVKSVIAQNIAGGIENDCITIKGFIFLHCLFIQRGRNETTWTVLRKFGYEESLELTHSYLYANIKVPVGCTTELSYKGQQFLTQLFEKYDSDKDGMLNPTELKNVFSCCPRIPWHNLRYTVPTNDKGYLTLQGWMCRWTLMTLMDLQNTSAYLAYLGFNFLENETQKSAIHITREKKVDIAKKQSSRNVYQCHIIGPRSCGKTSICRSFLGIAHKKIKPHANERGDSNTYSENCCINTVLVYGQEKYLVLKEIPITRVSDPLQPHEVNCDVACLVYDVAASRSFEYIARIYIKYFAESHIPVLIVGTKGDALIARQEYILQPDVFCNKYQLLPPQLFNIRENKHDVFVKLATMAAFPHLKHFASLSGDNSSWWKAGIGVAAATVVGLVLIKIFSFQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GML1</accession>
    <name>A0A835GML1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GML1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="21818" checksum="1A81CBD1EC282B84" modified="2021-09-29" version="1">MTGDFNLPNVEWSLSGMGIRWILYNSHKNTNDRILDLVLSNNYLDVAKCSEPLVSEDPHHYHRKFKKYGNRCDYDSFSALRDRGKILEREMFADYIDTIEKFGSLLSGRIFMFKSPRTHTVVVDPKGSKILFKELRKFCIFLTEGERFDNPSTQSVAQYNLETMKFYEHSEKIIPSEMVWNAAAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN05</accession>
    <name>A0A835GN05_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="438" mass="49316" checksum="2B7025637E2AB0C5" modified="2021-09-29" version="1">MQTLTAKKQPRQTIVQTRTAEKVVKPLTIAEMRADILSLRPVMSNTNTRVTMAPEAPKFPKPEYRPKKSMYLLQARNNVRISGINNISETPVVTKPAISRLTLANKENVSHQPSIKKLVPPKPLIRKQIIPTIPDTPMSNESWKSSCDASFLQKEKEINDAEAKTKAIMEEPTLENIAAVTPPVSTPFKEYRNVQEYFNHSSELESSAVYNDNTIMSFDKPSDNKENTAREESVIVSLCDLLNKASVATSGKISTELEDLLQIEKQTEHNLKMIDNSIAALNKIKESQLTSLKYVRKLINDKKPQENGDKTLTDTKETQEALVTVKNENSSPEHKSVVSKPCSVIKSCSKSPSYKIPKKNLCLRKKVFCKSMPNVSNETITPVKSDMGNRALSMYMKMKEHMNFLNTPVAKRDFIVPDTPAVTSHNLQKQLDKLYDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN97</accession>
    <name>A0A835GN97_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN97"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068">
        <property type="entry name" value="LARVAL/PUPAL CUTICLE PROTEIN H1C-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068:SF2">
        <property type="entry name" value="MIP24391P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032507334" evidence="3">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="221" mass="23817" checksum="D477F357333FBF5B" modified="2021-09-29" version="1">MIHKVLILLCPIALVNAGIISTDGGTYSSISTPNFKNIPSPVVEKTVATPITHTRIVQPAPAYHSILSTKESSYESPDGIQHTILTKSLDTGYATVNKHESRTNDGTADFNPSIYSSVSHSPIVYHQEPSYDISSPFVTKSESVPVTYTTHEVPSTRTVISPSLSSYSTLDKTKFATSGLSSYSSNSPVVESQPLKTTITYPEAPLVSHMSFTGLGTSYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA6</accession>
    <name>A0A835GPA6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stathmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPA6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12340" checksum="E0258F6E7B69E4D0" modified="2021-09-29" version="1" fragment="single">VAFEIPVEEFDGTKRASTPPAHLQRLLQPVQPDISLPDIEEKLAEAEQRRQSILQARAASAQKRAQKIMKNVQEMDRLDSEHEHSEPTKHVRNSLTIPPEPGVCEDKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPI7</accession>
    <name>A0A835GPI7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPI7"/>
    <dbReference type="OrthoDB" id="6095487at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="714" mass="79777" checksum="59B7F90A69AC5EBB" modified="2021-09-29" version="1">MERLSHDLNLALEESNCGRQERRKLGLRRRTRSAGNLPAAVAVSLVEDGSSSSPPQAPLITQPLSDSDDPHLSLHKSSLKSRHYCQIGNFESDSFNENFSPTRPANARRKRKYKKMPVEYIDGKRSPPVEILSVTTEPNALPATIILQSQVLSPAIHVNKHKTLTKPESCIFRNAFCGKRKWSHRDKGDGCEMRERSFSGGCSSKSAYFSKNDFKSRKYDTDIPKKEPVLQPGKIILKSQNAEGIKSTTPTNTPSLPGSSSFNFVYKNSSKNGTPTLSKLTGYKITTDLPPFFNPTTSTGKNSFDGKYHRKFKMLNKSHPPSLRNPLMFDDSNSGMDCAGNESSSLSSSDSDGVVTNDSDREGDDELTDWPGIEELKVFNKSLTFKTSKSVNNNSPKSASNMPPPKRLKKEKLLVKSGWASCKNRFKKKRAKVDSGNDDDAMMSDSKTVVDLEDEAISKENRDILQPHSSFSSFSDIKNAGVSGQNANESFFQSFQAFQKKSAQQDESFNQAPRTNFSLQKTSSSDLNLSEKSPQSDHYYSEHSMGNAVVTEVREIRAGCRRIRDERPGFLILSAANEQLSKFLQDSCQTELKLPSLNDPEEKEKLESLAKLYSLELQVEMGRPVLRKTSNTMQAIRVEHSYHNFPSDHKRRCYGDDTDTSLSLSDQNSVNSINDLEDTQDVPERLCDMVQQDLVDTFSNSLVDKSHLHPGEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPM2</accession>
    <name>A0A835GPM2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fanconi anemia group I protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI helical" evidence="4">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 3" evidence="2">
        <location>
            <begin position="257"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="3">
        <location>
            <begin position="476"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="85086" checksum="8B9AD736C40747ED" modified="2021-09-29" version="1">MCMEVVSILRRCLVQDALVKQLLYSQLYDCAKDKQMLHESILELFHDHLIKYLPEDENAGSLLIDKCVQINGVNVVLTEPIGQLLFAVAQFLQTTEVEDLEDILSSQTVETGHAYLKSKLNRVMQQLCDADSFVDIDMEESNLSDMTPESKAKSLKVQQTLQCYEALIAHTVMQWTVTSNDSANKLYKLFKACNQILEQTKVLPKSSKKGNKTLNETRETIKSQKSQKSQKDKGKAPIKLSNLVKDKAGPFKPLPCLWDTRFCLKIIELLYSDEVSWASLEQRNQIRGRRDFHTWVLRCVQSVLLGDNLDKKAVVTHVVKIATILYNKAVCRFQHMCGFDDQVTVTCLEVFKTCLTLLFSPLYSLKMDCFLSNITGCNESSSECLASILENIHTALQHFEMDSVPDERDLVVKKQLGVLIQIAALLLETPTPSCPLKTRVLVKLEDYLRTSTQDCLALIGPVLTAGYSELQEAALLDELLVKLANVLGRIDEEDTSAGEESDKFHAIDSRTGHAVLVTICTHLATRARGLEHLLARARDLTVAAGLAAHSVEQRIEKDLTEIYKSVVVQLCQVSGWTSGCCKLRCSVGAASDRVLAAAVRLYCLLAALVKQIDPGMAQTVRFERLLKLCGKKLSSVTDNLITYLEASQNKETATKLLRETKLIPRLVLEAELFSKQLILLSNKAKLNWQQYLSLGTARDFRIKGPVLQEALNAQEQQDESINEDEVDINDAETDIIEGASDAEEEGSDKEASRKKRRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPW0</accession>
    <name>A0A835GPW0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPW0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="26603" checksum="67DD7163AFF99FFC" modified="2021-09-29" version="1">MLIGVGKTSLVVRYIGKMFSKHISPTIGASFFTCNINLDNARVWDTAGQERFRSMAPMYYRNANAALLVFDITSVNSFAAIKGWVKELQRLLRVGNRGESEQGLWYGRGCEWLCPNVPHLNVPEAMVLSVVGNKSDLEDLRAVQSSEAAQFAASIGAQYCETSALHDQQGIDEVFLNTAAALLKLSNSNLVSSLRSYDSADVDPDKIPTGTPTEEAATHTGKVELPAWSIDSIAHGDVQKNMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPX8</accession>
    <name>A0A835GPX8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_003539</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPX8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032999132" description="Alkaline phosphatase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9420126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="497" mass="54838" checksum="D190A0175D92BEC4" modified="2021-09-29" version="1">MRPRSILAFCAFIVTVRSALRTDRQFWTDLARNELEEALKVKWNLNPAKNVILFVGDGMGPNTVTAARIYKGGESHRLVYEKFPHMGLLKTYSANKMVPDSACTATAMFSGVKVNQDTIGVDASVPHRDCEASLQSEARLKSLAALALEANKSAGFVTTMRVTHATPSPLYAHSASRSWECEASLPDNSSCKDIARQLVEDWPGRDLQVIMGGGRQQLVSNATGTEHDPISLSPWTCYRQDGRNLIEQYKADKSTRGLKHSVIMNNKELAELDVSNTDYLLGIFSNEHLSYEHERNKGPEGMPSLSEMVGAAIKVLQKNKNGYFLMVEGGNLDMAHHRGWAKIAVNEALAMEEAVQLAADMTDAEDTLLIVTSDHTHSLSINGYPDRGSSIFGIAQPSSHDKINYTTLSYATGGPGSFQYYVHIDANGSRVMRRDPSEDDTEDYKYTQVAGIQLVENYHGGGDVTVYARGPYSHLFHNVHEQHYVFHAISHAAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQJ4</accession>
    <name>A0A835GQJ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQJ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="37"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="366"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="459" mass="51729" checksum="57B720C1DC0C7ED5" modified="2021-09-29" version="1">MTYRQINEFDAEKFTAATVPTSYVSVPDFYAGKTIFITGGTGFLGKVFLEKLLYSCKDLETVYILIREKKGKTPQQRVEDLFNKPIFSRLKQKDSQCMKKVTAIIGDLSEPGLGISKDDEELLLQKVSVVFHVAANVQFYKEFKEIINTNVGGTKYVLQLCQRIKDIKAFVHISTAYCHTDQKVLEERLYPPPAELSEVLKFLQQPQHDKKQIKELFKKQPNSYTFAKALAETYIAENCGRVPTIIIRPSIISASLKEPLPGWVDSWNGATGLITASYNGANRVLLGEGGNFLDLIPVDFVANLAIVAAAKCTSSLKVYNCCSSGCNPLTLKQLVSHMNNVGFDKNVSIIFTNNKASLSTLTFFLQTTPSFTADMFLRATGKSPRYMKIQSKLTIARNALNFFTCHSWVMKADNSRRLYASLSLHDRHTFPCDPTDIDWKKYITIYIEGINQFLMKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRN4</accession>
    <name>A0A835GRN4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_011563</name>
        <name evidence="5" type="ORF">HW555_002774</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000620">
        <property type="protein sequence ID" value="KAH9634303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRN4"/>
    <dbReference type="OrthoDB" id="19729at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF12">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9634303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="116" mass="12517" checksum="B8183C1BD1165A01" modified="2021-09-29" version="1">MSASPIARQATNCQAIPSRRVLITDPSQMPDVYSSTPGGTVYSTTPGGTRIVYERSFMMSLRQSPISQTPPKCPLPAALLKNPNSVPNVIQPTAAQKARSNSISFDESQETFSMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS06</accession>
    <name>A0A835GS06_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_013240</name>
        <name evidence="3" type="ORF">HW555_001887</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000654">
        <property type="protein sequence ID" value="KAH9633563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS06"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032811848" evidence="2">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="292" mass="32075" checksum="3D13B646F55C8595" modified="2021-09-29" version="1">MNRSLIVVFALAALAVVITADDPPRPRLIDFNPWAWLPSNRNRSPSIMDYFFPPSRTPKQSNLDPPADRRPPETTSQTVENTPAPTTLEERSTTYAKKISTKTKSTAPVTNPTATTPPKTKKSTRKPITVTTTEIKTTQTKTEAPASTTKDATVTTYKPPTKHYTIRPVVRTTETPTVQDTETTLNSDSTETVSDFETAGTTVDGPKDTAPTLSTAEESRSTDAGTASTATVESTTPTDSTEPADSREGYLPLRDKPQQTHVKINEQTKKEEPDEVHYDCKKENKNTLCYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSK8</accession>
    <name>A0A835GSK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Organic cation transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSK8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50991" checksum="F815FE2DAB54052D" modified="2021-09-29" version="1">MGRCEVKQCEGMNTSLWLEYAIPKEKGKYSKCFQYAFKDTAGNGACTAENFDSNSKVKCSSYVYSDDDSVVKDFDLGCQNWKRTLVGTIHNSGFFLALPMTGIISDRFGRKKALSFAALMNCIFGLTRSFSTNYVMFVIFEFMEAGFGAGAYTTAFVFAMELVGPQGRVFGNTIINVFYVFGLMSLSGLSWILQDWRKLLRMIYAPSCLIFSYMWILNESVRWLLQKGRHDKAIGVIKKAAKMNKVQISDQALAPLQEMQSKPTERKDELVNQPKKSLFLQVIGSSIIRRRLLTCSFLWITCTFVYYGLSINSVSLAGNQYINFMLVAFIEIPANFTCVVVLDKFGRKKVLIIVYILSAILCIGLSFLPKVFPTNVRQSLLGACSCAGRVGSTLAPLTPLLALYYENLPSIFFGTMAIIAGLLVFTMPETINIPLPDSIEEAERLTKTKRRKNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSQ0</accession>
    <name>A0A835GSQ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001563</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSQ0"/>
    <dbReference type="OrthoDB" id="9799930at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9422779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="14946" checksum="971B191819E6A9A1" modified="2021-09-29" version="1">MPMLKSDSSKTRGKAKSRSTRAGLNMPVGRIHRILKNGNYAPRIGGGAAVYLSAVLEYLAAEILELAAKAADDNQRTRISPRHILLAVRNDDELNKMLEGVTISQGGVIPHIEQQLLPKKTNMKSQYNTNSSSQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTJ6</accession>
    <name>A0A835GTJ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_001659</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTJ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06383">
        <property type="entry name" value="PBP1_iGluR_AMPA_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000080">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000142">
        <property type="entry name" value="Ionotropic receptor 25a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032401810" description="Ionotropic receptor" evidence="17">
        <location>
            <begin position="19"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="427"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="437"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="78"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="774"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9422665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="103793" checksum="000D0CA5745B0BE3" modified="2021-09-29" version="1">MSTRTVFLLIYFIRITFGQTTQNINVLLINEESNALAEKAFEVAKEYVRRNPSLGLAVDPVIVVGNRTDAKVFLENVCRKYNDMLSAKKTPHVVLDFTMTGVGSETIKSFTEALSLPTISGSFGQVGDLRQWRSLNANQTRFLLQVMPPADILPEAIRAIVTKQDITNAAIIFDEFFVMDHKYKSLLQNIPTRHVITPVKSFEANEIKTQLESLRNLDIVNFFIVGSLRTIKNVLDAADKNQYFGRKTAWFALSLEKGDISCGCKNATIVHIRPTPDANSRDRLGKIKTTYSMNGEPEITSAFYFDLSLRTFLTIKSLLDSGKWPNDMKYITCDDYDGKNTPNRTLDLKTAFQEIKETPTYAPFYIPPDDPMNGRSYMEFSTDLLAITVKDGASISSHSLGSWKAGLSSNLTLTDPNNMSNYSAQLVYRIVTVEQKPFIIRDDQAPKGFKGYCIDLIEEIRAIVKFDYEITLAPDGNFGTMDENGNWNGIIKELVDKKADIGLSSLSVMAERENVVDFTVPYYDLVGITIMMKLPRTPTSLFKFLTVLENDVWLSILAAYFFTSFLMWVFDKWSPYSYQNNREKYKEDEEKREFTLKECLWFCMTSLTPQGGGEAPKNLSGRLLAATWWLFGFIIIASYTANLAAFLTVSRLDTPIESLDDLSKQYKIQYAPLNGSAAMTYFQRMANIEEKFYEIWKEMSLNDSLKEVERAKLAVWDYPVSDKYSKMWQAMEEAVLPNTIEEAIQRVRDSKSSSEGFAWLGDATDVKYHVMTSCDLQSVGDEFSRKPYAIAVQQGSPLKDQFNNAILQLLNKRKLEKLKEIWWNNNPESMKCEKQDDQSDGISIQNIGGVFIVIFMGIGLACVTLGVEYWWYKWRKRPAVEPAKLTRNNVDKQGDGFNFRGRNLGINFKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU10</accession>
    <name>A0A835GU10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="35872" checksum="4FB4DDA4B138B963" modified="2021-09-29" version="1">MAANVPSVTFNNGFTCPILGLGTWQSNPGEVTRAVGEAIDIGYRHIDCAHLYFNEKEVGEAIKEKIKQGIVKREDLFITSKIWNTYHRPDLVEKAVKISLSDLGLDYLDLYLIHWPMAYKEGSDPFPSDANGKVIYSDVDYVDTWKAMEKLVEKGLVKSIGVSNFNSVQLTRILNAATIKPVTNQVECHPYLNQTKLFDFCKARAVTLTAYSPLGSPQRPWAKPGEPSLLEDPKVLSIAKRLNKTPAQILIRYQVDRGIIVIPKSTSKSRIAENFNIWDFALSEADIKAINSLDCNGRLIPQAEGREHKDHPFANPDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXS4</accession>
    <name>A0A835KXS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000745">
        <property type="protein sequence ID" value="KAF9405417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXS4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="133" mass="15019" checksum="C5B4C44811990B13" modified="2021-09-29" version="1">MFRRPEPSVRWLVNGVLVDEEYEHNTGDVIENRLLWPAIRRADYAAVFTCQATNSHLVPPKELSLVLDMFLRPLTVEIKKPAEVGEGGVLTAERRYEVACESAGSRPPAVITWYKGKRQLKRITVSVTTSPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYG7</accession>
    <name>A0A835KYG7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_013075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000570">
        <property type="protein sequence ID" value="KAF9406618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYG7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19874">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000037">
        <property type="entry name" value="39S ribosomal protein L44, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="38"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="223"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9406618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="321" mass="36784" checksum="45E12F4DDBCA2487" modified="2021-09-29" version="1">MALIRRCVPLLTKVVRIHPITVQNQKIHRWVAPTLMELKRRENKVGKKINPRNTYLEWNLEAELYGFARRLNEEFDSDLLLQAFTDRSYVIKEEMKQKEMDFDIKLKDNRELAEKGDKFINAYIQNYLETVLPKFPMEGVKGVRSFLVSEDTLANISLNLGTKDIILAAEYPVDNYILATNFKAVVGALLESSGEERAAHFVRDFVITQLNGQDVNEYFPIEDPWSMLVDIMKREGVTLEPRLIGEVGRNTLLACYRVGLYVDKKMVTSGFGETVAIAKEMAAREALKKIFGTEDHMKPIDFKIEGIPKPSSQTRYQISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYV3</accession>
    <name>A0A835KYV3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000603">
        <property type="protein sequence ID" value="KAF9406366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="341" mass="39582" checksum="775DA41EE718A423" modified="2021-09-29" version="1">MDIQPCGNVTAVSYYIAKYTSKHEPQDVGQAVKDAVSKVRSCHGDIGRQLFAVSMAILNHRRVSACECAYRLCHLKLRDSSRKVVFVNTCRPHERYRMLRYDSDDGQTYQNIFDRYIQRPTNLEHLSLAEFAVNYEHTSRFVNDEENGDTEAYEDLEEGTETTRNSIRLLNGSIMKRRRKPAILRTRYYTQTGDREGYFYSYLVAHVPFRNEDDLLADFETCEEAFMEQRNLLRPFHGDSVEQFQFIERELQQVIGQVLALAEPPLLNNFNGQQTENFDVGAIVEGYDPRMADADVDIEGEEVEESSHINITDAEFHHIVRSMNLLISFDIHIHPFICCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZC4</accession>
    <name>A0A835KZC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000768">
        <property type="protein sequence ID" value="KAF9405277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="103"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="301" mass="34440" checksum="8736785A070DBD46" modified="2021-09-29" version="1" fragment="single">NQTMMFGFCEALLKEDTSNYGYNSDDETQRVGGSADSDTEQELSDDDGHTHVQDSDKDDIIYTGKDGTSLWYSNPKQAKIEPLAIEPTIPGVNPFARNAKTEIECWNLFFNDEVLGDILYHTNEEINSKTYSEHHNTRVHIIKETSMDEIMALLGLMYITGLNNSTGYNLTDLWRFRWYRMTMSLQRFNFLQGCLRFDDAATRAQRSAVDNIALVRDIFDKFVANCQKVYNPNHFLTLDVKYIPFRGECPFRQFMPKTSAAYGIKMYSLVDAKDSYTINMEINADCVKCTTRGITVKAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZH8</accession>
    <name>A0A835KZH8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZH8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14054">
        <property type="entry name" value="REPETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14054:SF14">
        <property type="entry name" value="REPETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="846" mass="75371" checksum="657BE302338C2CD8" modified="2021-09-29" version="1">MLFLSTSYCKPADGLPDGISLNDNSFSMPDPFSFNPFTSQHQQAAPQKQAPTPNLFNPGTILNALSPKLPQNPVGSLVSNFVSSILPTSHANTASGSSSNPSSLANGSPQLSSPTGSPSVPQSNGNLASAATNPSGSPAPSLPGFGGVPIPSFPGGSPTSPNLSGTDSGSLPNAVTPGVTAPSGTTTKGAGGTTAAGATTAAAGATTPAGASTADGANTPARATTAAAGATTPAGATTHAPGATTPAGASTAAGATTPAGATTPAPGATTPAGASTAAGATTPAGATTPAPGATTPAGASTAAGATTQAGATTPAPGATTPAGASTAAGATTPAGATTPAPGATTLAGASTAAGATTQAGATTPAPGATTPAGASTAAGATTPAGATTAAPGATTPTGASTAAGATTPVGATTAAPGATTPAGATTAAGATTQAGATTPVPGATTPAAGATTPAPGATTPAGASTAAGATSPAGATTAAAGATTPAGATTSAGASNAAGATTPAGATTPAPGATTPAGASAPAGATTAAGATTPAGATTPVGATTTAPGATTPAGATTPGGETTPAGATTAAAGATTPAGATTAAAGATTPAGATTAAAGATTPAGASTPAGATTPAAAAGPSTPTAGPGATTAASGATPTAADSTPVAASSTSTPTSSTPSITGGAASPTHSSPSLPNFPNLTPGNIPNPMTGLGSMPSEIPSSVGSPVNPGQAVSISQLQSAISSQGVPSSGLPSSLPGSLPSQASAVQNAASSAQAISSFAPAGSLLSAFNPQSAVSALSSSAQGNPASGFSSISGAAQQFAGNANKVAGAAHDLAGSFVGAAHDITGKATNLAAQMGGAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZY4</accession>
    <name>A0A835KZY4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000251">
        <property type="protein sequence ID" value="KAF9410692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZY4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="339"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="478" mass="54647" checksum="142FCA0311F61F76" modified="2021-09-29" version="1" fragment="single">VFFSVLIEKLIRSCGDINTIYVLARNKKGKDPRVRLHEMMDEFLFHRAHEENPKGIHKVVPILGDMELPGLGINEEDRKMLASKVTIIINAAATVKFDEKLSVSTAINVKGTKEVLKLAKECRNLKAITHVSTAFSNTQVKHIEEKFYEPPMSVEALEAISEVDEKLVESILPTLLGSRPNTYCFTKAVAEEAVRTYGEGLPICIVRPSIVVSTYEEPVRGWTDSVYGPTGLVVGIGTGVLRTMYMDQEKVADMVPVDLCVNAILASAWHTAKNYKENQTSHIPIYNFVSGAQNPLTWGEFIERNRKYGIDKPTTKAVWYYGLNPTNNYYLFLFYNFFLHYLPALMIDTYCAITGKRRAMLKLYSKVMKLANILFYFSTQDWKFSDMNVRNMWNSLSDADRVVFPFSIGEMSWEYMCETFLVGLRVYLIKDDLSTLPEARKKWNKLFYLHQTLKAITLSLVVYLTYFVLQPIIALVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L002</accession>
    <name>A0A835L002_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000247">
        <property type="protein sequence ID" value="KAF9410764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L002"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="522"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="650" mass="72645" checksum="570866A692A018ED" modified="2021-09-29" version="1">MTEAGFVKAQSDNLPKIDAFMMTAYFASNPDFTSAEIRGVKAARSTRESYGDSAVGYVQVKRDGDICVVKARITPEHNVRQKCYAVICTCNETEETILSVQCEDCAAHLGGCKHAIAFLAWLHRRSEDPSTTSIECYWKKSKLSSIGTSKKFIKAKEMYKTPKHELVPTSLNTESFLTVVKNNCTLVGDTKNHLMKFYRAPSTVEKLSIHHLLSTSKATNPLDFIEYCKLIMTADACKGAAIATLEQNDCPLWHELRYGRITASKAYDAAHCNTLDGTLTETILGASKLRDTEAMERGRLLESQVLKEVEKICKIKISKCGLKLNSTHPIMGASPDGENSVYSIEIKCPTSEKAMGRYVSSGNKVTAKYMAQVQLQMHFSNKAKALFCVADKDFEKTKKISILEVNYDQQLCENLLEKCDIFWNKAIFPKLNITMPIDLYYVPGSAPCRAVLLTAKALNLNLNLKLVDLHHGEHLKPEYIKLNPQHTVPTLVDDGFSIWESRAIITYLVNKYGKGSSLYPEEPKARALVDQRLYFDIGTLYQRFADYFYPQVFGGAPADKDKLAKIEDALQLLNTFLEGQKFCAGPTLTLADLSLVASVSSFEASDVDFKKYPNIKRWYETVKTSAPGYLEANEKGLDAFKGLVNSMMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1S5</accession>
    <name>A0A835L1S5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1S5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053064">
        <property type="entry name" value="Ankyrin-MYND_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15897">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15897:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1085" mass="123607" checksum="48C0F49E7B6EC391" modified="2021-09-29" version="1">MPCNPPKTNATKRWPYDEYYLGERDEENRKNGYGSVYWSSAEFQDSYTGSIVRDTIHGEGEYRWRYEGAEHAATTYEGRFYNNRMHGYGLMSYPDGRVFSGLWRKSIRWGPGVETHAQLREDVGLWHGYQLIRLAWRPNMPSVAIDIMSNPVGLNMVVPHRKLMTSTTKIIGEVNSALDLLKQYRANPLTAAEKWTKLYPKNCTDTYSQLCHVAVFDRAYFNNNEVRLLTEVTTVPQEINTSQSSKESVAETKTYYAWNNSKVIMHMMKHCFTHEDQWNQSRLNMKHILSGPRTAFKPPGKYELDCRSLLMASYLGHISNVAQLVNEFDVMPDITDNQGNSAIMYAACGDQPEIIHFLVEAGPDIDSFNDACCTPLGITILRYALEKKNIPYSAMLQAILPPPALVPPPPDESIQEWNISRDSQQTTERSDVNTKSSPGNKYSTSIQQPLEKKKAEKNSLDSIADTAEDKRMYDSLNLEYMIKVAEVYSVRCEVNPVPYIFEVYNMCKDVEVSIGDEQKKVVEKLMKKSQSKNTKQSMKPSRDMMWQDQDDAIDATEQKNREKISRIMATITLLLADGADPRLIRCPQPPLFMAVVAGCPDLIRVLVKYGADVNEIYPQAHEYSALDIAVSAPVSNENLGVIRALLECGASPDHRLKIPETPQSPNATPKIDVEGPTLLHAVLSKKIENDELENRHLLEVRDQILGLLLEYGCNPITQFNGVSAVDLAMNKSLDLFDIFVKSPRTDLNAVINNLNQTILVKMFYLPFCKNIPLTERLQMLTNLLLFGADPLLKCQNGKEEYGNLFVFARKIINDIEATRKPINQSGAKKSKSDARPKKDVSSKHGLTKATDDNQGDYKQALELVVDCARLLHIRWLQAKLLKELIDIVYEYRHRSWNMIMKEHKNKKCTGLWLTAARCLEIWDVLKTTKKKLYNDKKIQKQVLCIIHFYYKKMRKIIQIPLTFQDKEIIEREVASLIHEHKMATISTADMVPAVRPYVAPELTVKGIEKFNVCFECATPFQDSKINCGTCNLIGFCSLDCIERNIERINCHPCSSVLKNKYFPTPESTITETSEEPNKQNSTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1T7</accession>
    <name>A0A835L1T7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine kinase</fullName>
            <ecNumber evidence="8">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000241">
        <property type="protein sequence ID" value="KAF9410900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1T7"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000200">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="289"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1127" mass="128914" checksum="A6D636390DF3BB8B" modified="2021-09-29" version="1">MGSNILKSPRARRVRTTSMSQPNKRTTAESILHADRRTIYTAGRPPWYNCTGGQEVEPFLIGICGASASGKTTVATKIIESLNIPWVTIVSMDSFYKVLNEKQHQAANRNEYNFDHPDAFDIELLISVLQRLREGKKVEVPIYNYVTHSRENRTKTMYGANVIIFEGILAFYNAEVTKMLDMKVFVDTDADIRLARRLRRDIVQRGRDLEGVLKQYMTHVKPAYQSYIAPCMAHADIIVPRGGENKVAIHLIVQHVHKQLQLRGFKVREKLAIAHIGQPVPDSLYVLKETPQVQGLHTFIRNKDTPRDEFIFYSKRLMRLVIEFALSLLPYSDLVVDTPQGFSYKGRKCDVEKICGVSILRAGETMEQAVCDICKDIRIGKILIQTNQQTDEPERLTSLEAQWVDFNTRHTLLSQEIEDKNINYFMDDIYGKTKIMYENTKADMVKLLQAAEENVKFDLSDLSAGEADEKTKTLLTQQECNFKAIDRAMGKIDFDNVSEKWELDDYLAILKSKWERIDSTHWELEALLKGSKNSYNEMFNSMEAKYDEARKLLKSKMWSTAHHQQSAPKIEIPEFSGHYNKWISFKDLFLETIHKNPTLNKAQKMQHLKTKLKGEAERLVQHLSISADNYSSCWAILTQRYDNRRLQFSSFMNTMLQLPVIHKPDAYNLKKLHDVTTECLNGLTNIGFDITSWDPMIVHLMAQKLDCGTFNEYIKSLQDNREVPTLQEFLTFLENQFTAFETMKSSKKESQSAEKAAGTEKHASRNYEHKKWQLKTYHTSYGQCPLCKNNHVLMRCPQFIDSDTKQRNSIVAKLRLCKNCLFRHENETCNSVKTCKECNMNHHTLLHYNKSHNKIANSTSTENQRSGQRPSKETGTASSNHLSANNMEVLLTTVQVKVMTVDGTYINLRALVDQGSQVNLITENAAQLLRLPRNKLTAKISGVGSVSGDFTIKNTDQEPEDQCEAYYKETTRRDSDGSSLTKTIRIVAWIRRFLGNARNSTKRDTVCLSFCELSNAEELIIKYLYYLRLPKDIKDYRVILMDATVATGAAAIMAIRVLLDHDVPEHNISLVSLLMAEIGVHSIAYAFPQVKIVTSALDPEINEKFYVLPGIGNFGDRYFGTEPADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1W8</accession>
    <name>A0A835L1W8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000238">
        <property type="protein sequence ID" value="KAF9411035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1W8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="110" mass="12684" checksum="B49F18B71853CA02" modified="2021-09-29" version="1">MVPYLTLRNIHIRLQQLKQDQGNFGGINVILFGDLMQLPPVSRITGGSYCFRQPSNLTGETNLWQLFSFCELPQNMRQAGDNTFVDNLNNIRVGELRWTNLRSWTAAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L229</accession>
    <name>A0A835L229_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000301">
        <property type="protein sequence ID" value="KAF9409741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L229"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="19527" checksum="FA4F966079759149" modified="2021-09-29" version="1" fragment="single">DRHVTFFHESQHRSADRVRSGQRTGRTSPNFSYSPRPTSVLVLFRGPCCVNTDPCYLILSSRMSYERRDHTRCVNYALVMYRNRTHNRVVICRVVSGTPQVNNNAPKLDRAIDPTTRRGRAVYSRHNSERWRCVRRRRVCRERSLSVACGGSARLCAVCDRRGSAHAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2A6</accession>
    <name>A0A835L2A6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000140">
        <property type="protein sequence ID" value="KAF9414168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2A6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="522" mass="56396" checksum="A60DB94D11AA07C1" modified="2021-09-29" version="1">MADTMASGAHPVVACLSSHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRESNPKPFGTKNPNKRQVHNLLSIVLFSSNLPTTLPAPDQGWHYDNVTDPPWITSTLVLATLGQSWAYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRLNFKAIPSQYEGDWQPRHAPTRGRHEPGPSTTRLSVTRLQEKAKQAHNQQQQQQEQEISSAQGSVVSVITHAGNAPGTTAVLSPTTDQHVTNTGSYSINGILGIEQVEGLHNGNATGLKRKRHEDQDENRDFNSHSEDDVKRQRSHYNGDQIYSNLWSSSKWSLKDEYKLLSELGGAAGGATGYYGELFDTPYEHAAHPHYTPHSATNDSTGSNGGAGGEPPSAAASPDAAALVVLQPPAPPYPPYAHYDEGGAVGDHTGFVWANEPAQEPAEQKCCWLKRVRPTLASEYAYAAPYSQYSPYGGPYSHSAATGLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2G5</accession>
    <name>A0A835L2G5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000267">
        <property type="protein sequence ID" value="KAF9410331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2G5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="612"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="747" mass="86281" checksum="8473C9BC4FF32FD2" modified="2021-09-29" version="1">MGEVLQNVLDTEDYHFNSSVYEDGNETPTGSDSVQEAQMTSTLEQEPELPSKRLRKPPDRYGYMCISSTVPASEEIVFSEALAGPEMVSSFKMSEEDENLHRLAGSSGDAPGGLIIKKKDPPAEFQFAKPSLLGLDKLAAAKRKQNRLISFQDDTNEDDGEDSKSEASSSKERKYRKHNEETPTYTGGISEQARERMLERLQKREKEAKEKGVHYSTQEEKKSRSKDDEDDRYYKYRYDRRDRDRDRRRDDRRDDRRDRDRDKDRRKDGRDSERSYRDSERRGESSRRSYYEPRFKDEPRTPSMKVLKPTDKTAWDDDDDDPKAPLRKSSWDFPTPLTRDGGDRSQRSERSGRPLRDYKGRLYENTPRATPHKFASSRRGVDIDDPEWEEAEKKLDRAWYNMGEGEADESDPFAGTSADYVARKEEQIEKRRNRKVSAQRQQIDKDNELWERNRMLTSGVVHAINVNNDLDEENVDRVHLLVHNIVPPFLDGRIVFTKQPEPVIPVKDPTSDMAMNARKGSALVKAFREQKERRKAQKKHWKLEGTKIGNIMGIQKKEEEMEDGPTKDAYKYAEHMDKDAPEVESKSDFVKKMTIAEQRRFLPVFAVREELMQVIRENSVVIIVGETGSGKTTQLTQYLHEEGFSRLGTIGCTQPRRVAAMSVAKRVSDEMNTKLGDEVGYAIRFEDCSSPNTVIKYMTDGILLREGLREPDLDNYCAIIMDEAHERSLSTDMLFGLLREVSAIVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3B8</accession>
    <name>A0A835L3B8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000138">
        <property type="protein sequence ID" value="KAF9414245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3B8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="134" mass="15195" checksum="27CFCA6D78BD3832" modified="2021-09-29" version="1">MVPPEIISRHKRGANLNDADRSSFEHFVKKKPDFQSKIIDDNTDTIPQAITSSKLHSEVKIYRIRRVYPIRESVQTGRAERSDACTLTFFRYGRARVIATNKMLSARSFEQARAPGGPGGNIGWKVVQRQCCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L429</accession>
    <name>A0A835L429_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L429"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15669">
        <property type="entry name" value="ePHD_PHF7_G2E3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042013">
        <property type="entry name" value="PHF7/G2E3_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF42">
        <property type="entry name" value="G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="763" mass="87681" checksum="F036C8C6115FFDA6" modified="2021-09-29" version="1">MKCTIVTMAPRKSIKKRIVAKIVTGNRLPCAFCQCEVDDELTYGKLYAIGEIHCHYFCVLLSSCLIQRGKDVDGLFGFLYEDIIKEIERAKKHKCSFCSRPGANLGCSVAQCKKQFHLPCGRERNAVSMFYGNYKSFCQVHAPKQNIPPAIMENAKQRMRKDNRNKKKISNFKDLKELSICDGNEVTDSDTQSVCVICYEVVDGYPTRMALSAGMHYLKCPLCNDKDNFYQAVVTQGYYVPDRSWCIKVCLLCGSSGVHCACAGSANKLYVCGDCTPAAPDSIEELANCIEAVISQEQRQTSSRSRRGPVMPSRMSLRRTKRNTSQNMPSCSSSVDMEIKQEVKCEPQTNTALARQELNIKPPKIQETHILENIHKQNTATQPDKESPKKIDKETFEYKYESPMKLLEESLRVKMKNLGAKNIILDEKTIEGLRKKFKKPKPLREKRKIVNDILNEVFDNLLKEPKQKDPVIQWNSPKKYDTTPEVIEIVENTPPSISDKENTKTPIKQEIKSESPFTTPKKRPDADLATEYNKNLEITFKSPNKLKTVDILKNSSLEISAEHEMVNVDVIKIENNENEDFIKSLGLKSPERSQKCAFKFSPYNKEVLESQNVDIDVESFKDRYLNEVGLQRIKTENVTPEKAVKKTTKKMRKRKLNDEIVLKLESKKRKKNRKDISIKDKNIKVKIRWRDEELKVHIKDTKKIKKSKKYRQYVLECSPDNCSTVKPEKEITPLKRKYKKQEKSPDNLIQTSIQKFFKVKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4I4</accession>
    <name>A0A835L4I4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_015919</name>
        <name evidence="2" type="ORF">HW555_008383</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000914">
        <property type="protein sequence ID" value="KAH9628389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4I4"/>
    <dbReference type="OrthoDB" id="10035275at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9628389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51025" checksum="0ED7F744521F0BC0" modified="2021-09-29" version="1">MALLYRATRLKDRADTHVFTFVVTRSATREPDRDVTSKDFCCAHQRWAVAFSRTDASLGVYLVWRGACEGMRVYVDFTFTLLSRDHFTANEGFSGKQVRFSAGCAAQGRGRCVSIAELNTKFADARGEFQLELSMSRVRTLYSCELRAPRLDTPPIAFAGFDWQVSATGGGGKEPLTLRLMRLSGEGQRCRVRYALALGEGERRLHSGPLECVCDADGRTPPWNPRPPSRLLTKGVRLTVELVWARAIAELAVPAAGRAATCYDRDKQAWAVRCDMHSEMVRLHMLYRDVHHVPRNHLRYVSWSAWLVRSGVAAGEPDAEELPGAPFEHYYAQDSADEGLMMETALRVEDMSRPGSAFLHPGGELRVRLEWGDTYLLFQATYHVYDDLCRLHAHQMRREIAVLQAENYSLERQLFSYQKSLAYAQAQAGEPAVAEASGRRSPAERSLSTDTEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Q1</accession>
    <name>A0A835L4Q1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Q1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114562" checksum="AD276994DEEAC0E5" modified="2021-09-29" version="1">MSKRNSTGATNTLFNYFSKTPPANKKVKSELEVEKSPNVNSPVRNGEKESKAENKKRERQITPSPEVKNNSESEDEAPIAPKRRKRIRLNPVDSDDSDVENKADNKMDTTEVEKPSMEKKLQDSFKYEPNQSPKAKPASKPPSKSTSSIKSSASPPKPPEDKPVVADDFNWIHCKLEWLKPEKIRDAQKRRPDHPDYDPSTLFVPPEFYKNQTPAHRQWWEMKSSHFDCVLFFKVGKFYELYHMDAAVGVNELGFSYMKGDFAHSGFPESAYGRMASTLVSKGYKVARVEQTETPDMMQERCRKIRREICQVTMRGAQVCGLQDNGPADPTAAYMMAIAEEIIYDRDALGLTPAVNCYLAIKALGGVVSCLTDCLLDIQVLGMNQFTSYAPPDVLNKTLPPEVKIENRWEGGSTMVLDAITLRNLRIVQDEGCLYERLNFCSTHMGKRLLYQWVCAPSCNISVIKERQEAVKALFENQELCQDAKSILTTLPDLERLLAKVHALGNLKRSKQHPDSRAIFYEEKSYSKRKVLDFISVLNGFTAALKLVDLFSDIDSKLLKRIMQFHPDGKYPDYRETLKFFKEAFNQEQAEKEGRILPGEGVDQEYDNTLQLIQEIEGELKEYLSKQEKYFKCRLSYVGTDKKRYQIEVPQNAAAKAGPDYNLEGARKGFKRFSTSETKDFLARMIAAEEQKTNVLKDLSRRIFEKFSSHYNQWETAVQCLSTLDILLAFTEFARQQSGDVCLPQITFEEDQKPYLNIVEGRHPCISNVVDFIPNDTQLGTEDSSLLLLTGPNMGGKSTLMRQAGLITVLAHLGSYVPAEECKLSLVDRIFTRLGASDDIFSGQSTFLVEMNETAAIVTHATVHSLVLLDELGRGTSTYDGTAIASGVCVELAKRGCRVIFSTHYHSLVHHLSSYPGIMLGHMACMVETDESAPDSEDNIPEETITFLYKLSPGACPKSYGFNAARLAGIPKEITLKAHQISKNLEKEATCVRAFRDILKMEDNPKDVRAMLAALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Z9</accession>
    <name>A0A835L4Z9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Z9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="360" mass="41301" checksum="C7D52C1029DD8ADB" modified="2021-09-29" version="1">MAADPLDELLQFLKPEARIDLRHIALDHLVGLSGTEEGITTLLSHEKIIQSIINLTDDKIEEVAKNALLILVNITANPRGVIELLKYKSDENKNIVKLCIGYVLNPEKKDADAAAMILSNITRVETELDNVLDAFLPHLNDILNAYVNINFNKKGSNLNFIGPMISNLSCCHSIRKWLTEEQPHIPLIKLLPFCSYELSNVRRGGAMGTIRNLSFDPEFHDFLLSNDLELLTYLLNPIMGGEEYIDEEMDTLPISLQYLPKEKQRDSDIDIRKMILETLNKLCMRKKGREFLRDNGVYYVLREYHKWETDPKVRLACENVVDILIQKEEEVGAEDLSAVEVPDEMKEKFEKMDEEYIQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L555</accession>
    <name>A0A835L555_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000101">
        <property type="protein sequence ID" value="KAF9415827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L555"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF17">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14957" checksum="1301E51D04B60261" modified="2021-09-29" version="1">MLFISLAEDARASSILCYDCNSAFDPRCGEEFDSFSLGIVNCSLRDPPEHLEPIEPTFCRSIKMEIYGKVRVVRQCGYVADDEVKEQSCRRVVGNGDLFVTYCTCNTDLCNSGVAQNYQQMAFMSAVLLLLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L676</accession>
    <name>A0A835L676_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L676"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51331" checksum="E612F57B73F838B9" modified="2021-09-29" version="1">MSPIGTTIIGNSSRKITSLVICHKCKKKVDIKSTALCSACDNRYELDCDGYPEHTYRLKDSEEKQKWRCKTCIRGKKYGKTDSTSGITLRKKPTVLKTTPPTQQVPNIQSNSTMLTDSHILTECETSNESYITPNKLSRSVDRTVSDMITTSEMKETIDQLTLKLESTENELENVIIENTDLKKHINKLSTEINTLKSLCKSTHIFKNPGSSTKKKKQTTLQQQQQQPSSPFSSTLQDEISEYVRRLEQEIVKLQKKLQIAEQEIALLTERISHGEGVELHNCETDAQASYFASKNAAGAKNKNKLYIISSNCTRGTLPLIEEVFYNQFEYCNYIVPNVTSKDFLRTIRYKLKDFSMNDYCLIFIGEKDIQNGNHADILHNLNYSMKNITHTNIVICTPIYVKGALIHNYKVEFFNNLLLTDIKNNEYAYFFDCNATYRMKCFPTIPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6E3</accession>
    <name>A0A835L6E3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6E3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="349" mass="39142" checksum="08091BF4071B2B66" modified="2021-09-29" version="1">MRLIMLSAQHTLEECPAWASERRVLVAKIWQRQVWREVASFCETSYLQDKDMLDLDSDRYSSNDGLKTVKALADLDYTRLLRKRNVCRDNEFDLKNLYQLNWPQLYSLCRNRADDCRADWRLERGAPLTAAGARFDVVWRAEGYALGPSLKKCTRLMLHGRALKTGRRCVQMAAALEAAGLGAEENCSGIGVVGLVGGGDASRSDIGVLSRIKVLVTLFSLNLLVRYTVQCSFHFFRAALCSRGKTKNVRKIYVLGGQRCIGLGEKLARTRINTKYEEYKVSSLIKPWAPSAEILNGCQNIEDLPENYMILSIGESDTNPTKITLYIAALLSVADIIKLFLDISIGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6I5</accession>
    <name>A0A835L6I5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6I5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033110135" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="519" mass="58795" checksum="C4FD4F2EDDAAD707" modified="2021-09-29" version="1">MLIFILFISFCECAFGHGVQVEVNTLDGVVQGYNEANISMFRGIPYAEVDENNPFADAHPYPHFDKPFVAIDDSTICPQYVNGIKGSIQCLRVNVYTPQDAHPGLALPVMVFLHGGAFYEGSGSLTDWAPNFLIKHNVILVTVNYRLGPYGNLCVPNTQYNNQGLKDQVLALKWVKRNIQSFGGDSDNVILFGHSAGSISADIHLLYNNDSLFNKVILQSGQAVTPLINDATPYKKYATDIGMTDENIDVDSLIQKLSSISVETLINNTKNYTFRPCIDGNFITSVPPKKNLQNVKIIVGATDKEMLFFYRDVTSFENFDFSSELDRPFDYSMLNPNVIDDIKEKYNLKLNKDELKDSTIDFGSDLAFNYPTERSIRYYLQNNATVYRYVFKYDGDRNFVKKREHITWPGATHGDELGYIFDIMSSNKITDLHVIDWIGLLWTNFAKHGNPTPPPPSKELPVTWPPISTLSEPYLQIGKELTILNEPLKTRMAFWDSLYKQHGKYAKGINLGEKWWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L708</accession>
    <name>A0A835L708_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L708"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="16453" checksum="D2A62F96F1036ED2" modified="2021-09-29" version="1">MPMLDLKVYVRVVAAVFSISSATAFVLALMRLLNPDLFYLDPLEGNEIGNDALGVHYFISGLMIVTSGIGFLNSCVTMNRSASQNTGRNITTWLLLDSLFETTRVIYVFVCEILLKGKGPMQLYELLISAAQYLLDSFLYCQMILRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L753</accession>
    <name>A0A835L753_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L753"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="514" mass="57810" checksum="CA80C0AFEED1B75D" modified="2021-09-29" version="1" fragment="single">ESDSGRMDSLYERAIAEVGQEGKFQITFDIFYNVLLSGLWSMAYNNIILALTITPHICKLPQKPTNVTEYYWKSKYIPTLEDAVGAKKFSDCLIYTSQELNKTKECEIFDYDRTWFESTIPSENNWVCSNEINVANIFAYSKIGEIIGSFVFGWYGDVYGRRLTYIISLAMLVIGRFMSILASSSFVLFATGCIIASLPSWSATQSTAIVSLEISSPKRRASVAKLRLISMSLGMKLIESPQWLWVNRKTKDCIKNLKRIAKVNKTKLSSATEEEILTSGVAEANETEVLGPLALFSGWRLATNTILQLVCISINYTVVLLSSAEKSNGNPFLDFAWQSLAEIPGFFIASWLANNIGRRYTGVISTAITACIWIFYDVADWLNRQWLGSSLVFINRLTITISYYIINLFNMELYPTCLRQTGMSLGNVVSGGAGAIAPYILVVVIVHIIRVLILIITTIFGGILTSFFLPETLNAKLPETFEDAQRFGRRRRNRTFYMSVNLKNETIDSNLPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7U0</accession>
    <name>A0A835L7U0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7U0"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="67"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="302" mass="33352" checksum="D84B77B6802C0824" modified="2021-09-29" version="1">MRVPRAYNPRIQERILKRFGVYNRVFPEATTPSRIVPEHIVRPDYISLTEKSVAPKVPEIKNVEQIEGMQRSCKLAASILQKIGDIIQPGLTTDDVDELAHKLCVQAEAYPSPLHYNGFPKSICTSVNNVVVHGIPDLRPLDNGDIVNVDITVFYRGYHGDCSKTFLVGDVDDRGIQLVSITEECLDIGIKCCGPGVPFKEIGSNIYRHAKRNGLTVIPSVLGHGIGQYFHGPPEIYHSINRYPGVMNPGMTFTIEPAVTHGSKQTVLLEDGWTLVTEDGSRCAQAEHTVLITENGAEIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L852</accession>
    <name>A0A835L852_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L852"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025848">
        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9423360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="529" mass="58474" checksum="2E3F6F2B446AF225" modified="2021-09-29" version="1">MSDAWEEIQAVKSKRNSLREKLEKRKKERQNILSANLGSGERSEGSPGGGKERLAASPSTGKHDVTPDKPKVVVPSASLEVQLLQVLSDMQLQLPATASALLPGLGDVDAGIVASLLQKFATQKLITIKERTESTTDASIEVVSAESVRLAAVLAALMEEQSNGNKRKGDNKTEEASNPKVSKTTTDEKKTGKNDTDIMSLLAMPSSREKAVKRVGEEIMDLLSKPTAKEKSLADKFKSQGGAQVMEFCPHGTRAECMRAFTTSKSEEGEDSAYSCKKLHFKKIIQGHTDESLGDCSFLNTCFHMDSCKYVHYEVDNSDPNANAPKPPETTPKGTHNGASVVSKPDGVLTLTPPQWIQCDLRYLDMTFLGKFAVIMADPPWDIHMELPYGTMSDDEMRCLGVPQLQDSGLIFLWVTGRAMELGRECLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGSPENLNRGLDCDVIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNVQPNWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8K0</accession>
    <name>A0A835L8K0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipoma HMGIC fusion partner-like 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8K0"/>
    <dbReference type="OrthoDB" id="10048434at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF19">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9419162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23799" checksum="66C7C44BD97216EB" modified="2021-09-29" version="1">MCYVIVTGRSLAWLLLSLVAFMLILTGIMTPKWLMGQPVVLNENNVTSFYVPSVGIYNRCIRMKNDRNNCASFSFYGLATDAEVYPTPWKAAMFFLSLCAAIQFATVLAGVMACCVQSVFKKSVISLAGATQALGGLFGVLGLLLYPWGWGATRVKRLCGENSEPYIPGDCSIGWALFVTATGVAQIFLASALSKTADKAANSDKVQFQMDEGKQLICLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8U7</accession>
    <name>A0A835L8U7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8U7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="148" mass="16017" checksum="3E6A53EF273BF193" modified="2021-09-29" version="1">MNSVPTCNDVAVNDVNHGSVPVRVCHVQCAHDAIHRLLNDAYKIPKNGLKHWRVIIVIVSASHLLKRDSACVRKSRLTTTLIDVELNKWWSGVGPGCCTAPAVPSRACDAERSPPPAPPPAPPVLCARPCCRDATLVPILLALFSFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L925</accession>
    <name>A0A835L925_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sidestep protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L925"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF28">
        <property type="entry name" value="SIDESTEP IV, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="226"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="421"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="519"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71410" checksum="D3FF5FC95595B89A" modified="2021-09-29" version="1">MILVPTSDVQGVLGKKASLPCDIQPLHSDDDVVMVLWFKESDGDQPLYSYDIRGRSINQPKLWSSPTVFGNRAFFRGSATPAVLMVDNVIASDAGVYRCRVDFKNSPTRNLKVNFTVIIPPNRPTIYDAKRRDRTKLVEPYNEGSNVLLICEVEGGRPRPRVTWYLENVVIDDSFEQRADGVTVNTLTFPNVGRQHLNSRLVCQASNTNLAQPETKVLILDINLKPITVNILTKEKQVSADKRYEVECKTTGSRPEAYVTWWKNNRQLKRMAKNFSENNETLSVLSLVPSVEDDGKYLTCRAENKHIQDSAIEDKWRLNVHYVPIVDLKMGSNLNPDEIKEGDDVYFECTVKANPKTHRLVWFHDNSEIFHNEGAGIILSAQSLVLQSVTRAAAGDYTCMAANSEGKGTSNPVTLLVRYAPVCAERRDGELFGALKQETVSLHCSVDANPALVSFHWTFNNSGEQTELPPKLYSSHGHTSTLNYTPTTDMEYGTLACYGENAVGQQKVPCLFQLVAAGRPFHLQNCSVANQSIDSLNVECVENFDGGLPQTFLMELLELPSLIVRYNVSTNRTPPYFEIRGLPPGVSYRIDLYAVNAKGRSDVSTIETVTLKGQAKFTGQYTLASHDEGLLNNKRSSCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9A1</accession>
    <name>A0A835L9A1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9A1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="127"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="421" mass="49028" checksum="604F5A94517EF31E" modified="2021-09-29" version="1">MVGEVKRVSLEDVLTEKQVHHIVKQATGADTWTLGASDVRPAADGMAGFLGDHKRAKLDVLVDGEVKHIHLFIKRIPLNNQPKADLITNNSYFRREQFMFKVLEEIRDDNDPTPWCPKAYIYTDSIIVMPDLSVEGYASPYFLDTLDYEHLMLGMAALAKFHAAFTNYETKKSIANNRPYNTNDEHGSLLIEPAFCDSPFMKACAKLTANFIKAYSCKPYRNLPDLEDKIAKQYLVACETMREWKGTLNVLIHKDLWVNNIMFKYQDNELVNAMIVDFQLIRYTPPAFDVMTFMCLTTSRSFRDEYERELCDRYFSVFCDHLDDDSKRRVKDLGYDKENFLKWCEKSRMFGLLEPAAIHPFILMHPKVAQKTFDDPETYERLVNEDRTEPVLAYAQQCARYRDRLLEVSEEFIERYVLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9C5</accession>
    <name>A0A835L9C5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="53"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="432"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="796" mass="88885" checksum="149779CB717D7414" modified="2021-09-29" version="1">MGLAVPKNKAVHRDLPGAMNPGRPGERHSPEVEDHVDFKKRSLMKSCKTSKGVMMFMHGLYLSGDDCLIPGPGKAHCYVNSDNCYDVWVPNVRGNFYSRNHTTLNPNKDSKFWDFSVDEMAILDLPAVIDYVLLETQESQLSYVAHSQGVSMLLILCAKKPEYNDKVKVGFGLSPTAWLDHSRFIVIKLQSLIAPGLTLTGPLLNTEVLKRNGLVQNAGELFCGTTTLAYPFCSSIIFAALGYNQFQITDEVLPVVFGHTPSGTSLKNFIRWGQIQNNGFSEYDYGLPKNLINYGRAKPPQYDLSSVSMPWVFLGSENDYVANVTDIKFLQTKLQKSSLCVLSDKTFGHLDFIYGKDIPNYLTPVVLSYLETVAIAIAHGCSHDAAENAIRKIMKYFCCILLSIVHTVWSANDIETKFGIKVSPRQDLPFLELANYDGYIAEQHFVTTEDGYILGLFRLPIQKSCKTSKGVMMFMHGLYLSGDDCLIPGPGKAHCYVYSDNCYDVWVPNVRGNFYSRNHTTLNPNRDSKFWDFSVDEMAVLDLPAVIDYVLLETQESQLSYVAHSQGVSMLLILCAKKPEYNDKVKVGFGLSPTAWLDHSRFIVIQLQSLIAPGLTLTGPLLNMEVLKRNGLVQNAGELFCGTTTLAYPFCSSIIFAVLGYNQFQITDEVLPVVVGHTPSGTSLKNFIRWGQIQNNGFSEYDFGLIKNLINYGTARPPQYDLSSVSMPWVFLGSENDYVANVTDIKFLQTKLQKSSLCVLSDKTFGHLDFIYGKDIPNYLTPVVLSYLETGNYTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB15</accession>
    <name>A0A835LB15_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Envelope fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB15"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="74370" checksum="29FDE4D0E2DAE5BF" modified="2021-09-29" version="1" fragment="single">KPSYVIPPRSETVIECPVSNLSEVANLKEGLILDHKIRDGVFLANCIVSLKPNNRVNVSILNTTEHEVPIDNYEVKCFVCSSFSEPIEIIEHSAGIYFDPTSIVYFQTDNWNVITYVDIINIRPYMENIEKSIENISTFCEKAHNIHVVRSTINSFNVSIQKLNNNEILLNRQIEKLNYIFASSSRTNNNILNLEKINSMFNIIEGSLLSISNVLDTVLNSILFAKANILHPYVISPKKLYNELSNNSQLKRTNEFPVSLTLQNIHTIIDLSKLTVYYYNNKIMFIIQVPLMSPIKFNLYKNLPLPTPSDTNQYLTYVLIRPSKLFVAVTDDRLSYVLLDSISECKHVNSDYILCPSPSILSTINNPSCESKLLTEVTLSLPEICDSKVIYGVINVWQKLNNNRYIYVQSKPNKLTLKCNNNITDYILHGTGILSLENNCVAYFQTLQFHPSNVYKSTVPSQITLSFDLTLDDCCKYNILNESTHSINPIILSNIDLESLKLASHKLENLETEIHNSKNQSYIVKYGNYYSGLTYVMISAIIIFIIYKLCTKFFSFRNSSCCIQIYNQCYNTKQMKKHNNVHSSIELTEISDDLENDNKSVKSLPNIDSVSIRDKRLYNLHSYAQMEIIFGSAQHFLPSIRIILVPIALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBL1</accession>
    <name>A0A835LBL1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="142" mass="15465" checksum="F460862612D0A3D6" modified="2021-09-29" version="1">MNFLTLICVSNLVKFVSTNHSKSLSRDTAKSITRKYYSNVSTVLHTLRVSNLTATMSSKEFFVLVLSIFGGLKPDVFPECHDGKCECGSKYIAYNNVCYGLLDAKCSKPSHCLSTSYSCVSGTCQNVEHKEGNITSSSKPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBN1</accession>
    <name>A0A835LBN1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBN1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="419" mass="49231" checksum="9D424A6626755A9F" modified="2021-09-29" version="1">MSDTSNNLSFMCLLPTELLLNIFYHLPAKDLWKIRGVCTRWLTIINAITELDDLWRSFCIREFGAKFTLKARSKQKNGLSYFHLYRSLSLWNRLSDANEERDEFASASRMYEEIRNFVILDKNVLGVHKKGAIIYYDLETFKEGKREPITGDYSRYMENDLAIVIQSYHLELYLIKKAIFNITLDDSNTTFSNGKLFYLTDDTLYFVTLSDEIYMCNYYKRQLKAHYITRSEDGIMSLGYTNKQLNILTFHRKIYTIVNNEMVFVCALGPDSNLLHQLKEYNFLEQLDWRIYFQWMYVLNHSIPDDGLLRDIIIIRPYGDVYFVGSNWGVLRIYYAPYSDGELDIFHTTPVKQYNFMERSDCPVLSTCQILQIDVSEIEDGHLVIVAMPKKIATLKFTHSFNSGPEFALVPYRIPQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDC6</accession>
    <name>A0A835LDC6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDC6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF4">
        <property type="entry name" value="CHORION PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032440208" description="Peroxidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1100" mass="126948" checksum="9DF764DD4B7B615C" modified="2021-09-29" version="1">MFIVIFFCLSYVLSFSNGIAYDSFNGTPISKDEVLRHIRDNTTFWCMIDIEPCDPNEWRRLDGSCNNLRNPARGAIHTPVSRILPPSYDENYEPRKSKTGKLPLVRKLRTTLLSEGQVPDQVFSILATYYLIFIATDISNLHDTVNYILWTPHCCTPKGKHDHMCAPVEVPPDDPVHRYSGIRCLNLTKPLTFQELGCRQKNTPPERIQSATPLFDMSTVYGNSLDKALEGRKFEGGLLKYEEEDGRVWPPRDVNETNCFMNRKPKESRCHKTPSDEVNTLITINMMSVWFWRYHNHIANRLAKLNPCWDDEKLFYTARDINIAVEMQIFLYELLPLMAGYDNLIRDGVIVYDGFRDIYNEAYIPQMSMEFPLALRWAHTMQEGNLKMYNPHGDYLKKVPLVDLTIRTGYLAVDNNIDYLTQGTFRQPSAKVGDNIVDPDTLEKLSDIYDSVEDIDLLAAMWVEKPIPGGHVPRMFYSIVAEQLLRTMKSDRHWYERPNRPHAFTFEQLQEIRKVTVARFMCDVGDTVTEIQPRAFQRIGPGNELLSCDFIPDMDITAWKDHSCSESWNFHRPNYEPMKSKAGKLPPVRKLRTTLLSEGQNPDQVFSILAPNFLIFIATDISNTHDTVNYVAWTPHCCTPKGKDDPKCAPVEVPPDDPVHRYSGIRCLNLTKPLTYQDFGCRQKNTPPERIQSATPLFDMSTVYGNSLDKAIEARKFEGGLLKYEEEEGRVWPPGDATNASCIANRRPKESRCHKTPSIETNSLVTINMMSIWFWRHHNHIANRLAKFNPCWDDEKLFYTARDINIAVEMQILLYELLTLMGGYVNLIADGVIIYNGFRDTYNEAFIPQMSMEFPLALRWAHTMQEGNLKMYNPHGEYIQKVPIVELTLRTGFLAVDNNIDYLTQGTFRQASAKAGDNIVDPDMAERVLGYAQPSQDVFSNDVAKNRLMFMQPYIKYVEHFYGRKTLEKLSDIYDSVEDIDLLAAMWVEKPIPGGHVPRMFYSILAEQLLRTMKSDRHWYERPNRPHAFTFEQLQEIRKVTVARFMCNVGDTVTEIQPKAFQRIGPGNELVSYDIIPDMDISAWKDKSCSKSWNFIRHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEZ9</accession>
    <name>A0A835LEZ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine synthase reductase</fullName>
            <ecNumber evidence="8">1.16.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.8" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEZ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="474" mass="53722" checksum="385059BD415550FC" modified="2021-09-29" version="1">MKMVALSAFEDIIADLQEIEKLSLPEFKQTPLKVCYTNDNNTETTYDGSGPPLPFAASKIFDADILTWKRLTAANEDCKAVYEITLDVEDSSLTFKAGDTVGIIPQNDDSDIGFIVNHLNLASTVDLPYSIIIESNIKGSKLPIHIPVKSTLRHVLRYCVELRSLLKKAFLLSLSRYTKDDEERKILEYLCSKEGSAAYTNHVLNKRLCILDIFSIFKTCKPPIEVLLGNLPRLLPRPYSIVNSGLKNNKVMKICFSVMTSNNRKGLTTGWLERLILNREATLENGFKNMNISIESQSKQKVSIYLRKNFSMFCLPENLEKPLILIGPGTGVSPFIGFLEEREFLKETNQDIQFGDVHLYFGCRNPKLDFIYEEQLNTYLAKGTLNKLFTAFSRVNSEKKYIQDALTESGKEVVKLIKEGAHVYICGDLNTMAVEVKEILINCFVEHGDMTLEEAKAKISYMQKEHQYVVDAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFH6</accession>
    <name>A0A835LFH6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001324</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="543"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="826"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="977"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1003"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9423255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1064" mass="113048" checksum="A895AC111F06811D" modified="2021-09-29" version="1">MSSRAWVTLATNDSYGLGALVLAHSLRRVGSSYPAVVLITPSVTDPMRERLGGVFAEVITVDVLDSQDAAHLALLQRPELGITFTKIHCWNLTQYDKCVFLDADTLVVQNCDELFEREQLSAAPDVGWPDCFNSGVFVYSPSADTFTKLIAFAQERGSFDGGDQGLLNAFFSDWAHGDINKHLPFLYNVTSAAFYSYLPALKHYGQNLKIIHFIGAAKPWLQQFNFESGSVDAPEHIRGFLQLWWDLFVGQVHSQLDTGMVEVADTHEGPPALPPHDVGQQFHYQPTPDPESEFAWHHPDTQTKEETRKKEIDITEFHDPWTIYRGHIPPNTKEEVSQHEELARVDDHEEIRKIDDQRHDHNYYDSSDPNTQNFHAIHKVLEQHVQEKKVKKRNRRRRLHRIDVYKESILNGEVSGSETDDFDDIMPRHPYDGFYLRHRVTVDARGRKVCSHEVPPTPSPSPPPDSPVQDDSHLLEQSIPMDTNISDEQSGVAGNLARVLPGSAGQREALDELSRRQGWEAGNIDYMGADSFANIWAKISQTLSKPRTSPAKQSPPRESPPKSVPEQVVVQSGEGVQKPEAEQVEVAKEVVPAEIAPPTAVEAAPAPLLTSHWPAEPAPAPVEAAPAQVDAAPASEETGPTPVEPVPEPVTAAPASAPAEAKPEQVAASPVPVEAAVKVEASEATAETSSASVEAAPVPVEAASAPAEVVPTTVEEVAAAVEEAPASVATAPAPVEAAPIAVKSAPADPAPAAVESAEVPVTVEAVAPVEASAPVAEVPVTVEAAAPVESAAAPVVAEPSDVPVSVEAIVPDVPVPVEAVTPAEAPAEAAVQSEAPKTPEAVSVAQKTEASPVQSSPVLSASDSPPLAHTPSKEEASSPLAPAAKSEERRKPAGKLKLSPPAAADPLPTPDSELEDAAALASDIIARELLTPTVTAASPPVAQSPAVPENSRLAVEGPEVPTPPVGAVSLAQIGVKVPPKGKSTTAAQIESSITETVTPPTPDATTAPATPPIAATSPAQPSPPSDAPKKKIVKKVVKKDKEAAAGGDAPVPPPRKKEKKPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3G6ITM7</accession>
    <name>A0A3G6ITM7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="16">5-hydroxytryptamine receptor/serotonin receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_013072</name>
        <name evidence="17" type="ORF">HW555_012816</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2018-03" db="EMBL/GenBank/DDBJ databases">
            <title>5-hydroxytryptamine receptor (Spodoptera exigua).</title>
            <authorList>
                <person name="Hasan M.A."/>
                <person name="Kim Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="MH025798">
        <property type="protein sequence ID" value="AZA07970.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000517">
        <property type="protein sequence ID" value="KAF9407017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000777">
        <property type="protein sequence ID" value="KAH9631114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3G6ITM7"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036338852" evidence="14">
        <location>
            <begin position="36"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="100"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AZA07970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9407017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9631114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="564" mass="63336" checksum="39303D57CE50E00A" modified="2019-02-13" version="1">MATQSHNSYCSLPSFVALPSCLLVLASILLQPALASVELESILSPEFNVSNPNSTVNWTFLDDNSTFLKHGHIKHSKYSIPTTILLVTIFMIVIIGTIIGNVLVCVAVRLVRKLRRPSNYLIVSLAVSDLCVACIVMPVATVYDIMGTWPFGPVICDFWVSSDVLSCTASILNLCMISVDRYYAITKPLEYGVKRTPRRMLFCVFIVWISAAFISLPPVLILGNEKTDTSCSVSQNQAYQIYATFGSFYIPLTVMIVVYYKIFRAARKIVKDEKRAQSHLETHCYLEINVKNGGAAEAKLLGNQPAQPPPRGSTASTNTTCSVDKTESTIGRCFSGQRKSNESQCPMLQQPKTPTKPIHTINRSPTQLVPGKLAVKERQRQPSESSQKNTTNRIRSSLSNFAHKSHIAKDLLHPQNAVHQKKLRFQLAKERKASTTLGIIMSAFVICWLPFFVLALIRPFVKEDAIPDAVSALFLWLGYLNSLLNPVIYATLNRDFRKPFQEILFFRCGNLNHMMREEFYHSQYGDPDQHYCVNNTTKMHNYEEGVEIVSAVDREETRASESFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1Y3</accession>
    <name>A0A835G1Y3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_014187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000893">
        <property type="protein sequence ID" value="KAF9404752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1Y3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9404752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="35785" checksum="44CF1BFBF9FDED59" modified="2021-09-29" version="1">MNSLLQEIPKMSTKSDTWYHFVKKGSSGVCKYCHIEVKTCGNTTNLRNHLLRRHPSIKSTNEDIATTSTSKEKFGINDALSLTSSKEYYDSDLESIASSSVSLKKSKLNQLTMDSCVDNIKAFSEKVAAVVTDNGANIVKAVTIAFGKQKHLWCFAHTLNLVAQKPFEEKAGIESAKQLLNTVKDITRYCKQNVNVADALRKAQNDIAVPLKLIQSVCTRWNSIYYQLVRFVKLSELLAPILLNYPKAPPMLTASQLDGIKDLINILKPMEAVTKEVSVEKFVTSSKIIPIVSCLLKTYSTMKTETDEEQSPSNGGNEELNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2F4</accession>
    <name>A0A835G2F4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000551">
        <property type="protein sequence ID" value="KAF9406767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2F4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="4">
        <location>
            <begin position="97"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="680" mass="77924" checksum="19F62E6D5C262EC9" modified="2021-09-29" version="1" fragment="single">MPRKYKRKEGVRARVVSWTTEQLQSAFHELDKKELGINEISRRFGIPSRTLRRRYAIKNQTKLTLGKHPVLGFEHEKRLVAHILKLSDAGFPPDRRAILYMNKKSAYINTDLFYKWLTEHFIALKPQGKVLLILDGHSSHSSAPDMLQVASDNDIILLCLPSHTTSALQPLDVAVFGPFKTYFNHETNQFMRANPNKKISRYNAGTLIRNAWIRATTPANALAGFRRSGIYPLNPNALPDSVFTISDIAHRSDNDPDQPCVLQRTQTTIPPISSIDCPTTFENEHLCVANLNITPPNMPSTSFNRKSPSLLIDPQILEDTIIDIVDIGDDSLIRILDNQEKETPSKFLVEASPIPQIPLTLARRAKQSADILNSREKIKEKRDIADRKKKQIESKINKTEATKKRRTIKKANKKAKEQIQKNKNKKGKPKKNYDSSEETDGDVTDCSHKENDYYLKVNKDRGFRKRLAIYSSNSENEDHLSPNAEKDSEIIETGLQIYILSCKVKKWNDDVLKLRVEDRDEDDDVTTDIGSVLDEKNNLLLAIFEAWHLTIQISGLQVIFHFITAFVKVLVYVIVITFWLNEYISGPNMALSQSVGLVLIIPKMLFEQIFFCVTCELFDIEIERSNSIIIWKLAHDTTSKRKWKNMSRVLNTYFEKMSAFGLFFVDASFIIDYFKTITTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2U0</accession>
    <name>A0A835G2U0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_014146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000872">
        <property type="protein sequence ID" value="KAF9404829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2U0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9404829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="23158" checksum="08FB6AC4774633E1" modified="2021-09-29" version="1">MEALSKLGLIGYIGGWTEALILRVDESDRLAVALILMVWVSGITSAFVDNVPLTTMMVRVVTSLGTHPTLNLPIEPLIWALSFGVCLGGNGTLIGASSNVVCVGLAEQHGYKITFMQFFKIGFPVMIGHLVVATAYLLHAHQSRNSRGGVLLLGKTTMTIIQRCSKTPQNVNSKYSAYTYLGLLRHTLSLPPSMIPRAGTQEFRNASLRVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G323</accession>
    <name>A0A835G323_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_013633</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000686">
        <property type="protein sequence ID" value="KAF9405759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G323"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000003">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000095">
        <property type="entry name" value="Adenylate cyclase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="647"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9405759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="920" mass="102848" checksum="2A52C1368B7A8515" modified="2021-09-29" version="1" fragment="single">ENQCMRIKILGDCYYCVSGLPVSRPNHAYNCVNMGLQMIDAIRFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGIAGRVHITKATLLQLGGRFDVEPGDGASREGYLADHKVETYLIVPPKKVSENGRLSVCTVDRKASIVSSIYQDISPTKPRDNISPAPSQNSFNEMETFPSRVLRTESLRTTGDLSRRASVKVVAFDNNQATSPGEGLGNGTVVTSHKPKSRSGSIIGAISPIMGTATPGVPTRSRPSSKMTKYVECWGADKPFANITDSTLAKNIGISSLAMIEQNLLPQRTTCCDCSTNSEGMNRVTLWFKSSTQERQYRNQSDAQFKYNVACAAALFAVLAFIQLLTVPKGVVLYASFGPTFFTLLVFVYLSWYDGSMLTRGLRPISDVPDDLYADNCTKPGQVVANNRFIRLTMFVVSVLLIGACAVINLFQSFVIIDYPMYLRSNASNLTEYNFTEEVGISGMHIYNDVDSAPSYLYSSVLTLASISVFLRVGFVLKLALMLLTLVTHITLFASAELFYEYQKKDLENEFTMLAYATKAGMVLVFLAALLHILDRQIEFTSRTDFLWKDKLKFEQEEVETMRGINKILLENILPAHVAEHFLTFVASEAELYHERYSTIAVMFASIPNYKEFYDENDVNKQGLECLRLLNEIICDFDKLLLKPKFSCIEKIKTIGSTYMIASGLRPGKEEQNDVTSKEEHTVAILVEFAIALMTILDQINRESFQRFKLRIGLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSTGIMGRIQVTEDTAKVLMNAGYTCECRGPTYVKGKGTLITYFVKTPNVGGINFKVVLHFIVLGLNRYSYVKYNLKKMQIYTRIITYTQYLFKHCMIAAVKFKCALRNKLAKLPVCDLVFEIMQCCIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3W1</accession>
    <name>A0A835G3W1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000549">
        <property type="protein sequence ID" value="KAF9406774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3W1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032928095" evidence="1">
        <location>
            <begin position="18"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="50857" checksum="B976CC7F56AB236C" modified="2021-09-29" version="1">MIANIIGIILLTPAVLGQMGVKPDVSFTENNDRFDLTGMMQAPAFRDVPLVDDNDNDAPSDDDYRRKLNIDEPEDIDVLKQKSPKANIENTYLTRKSDGGFAYDDKMESKEGGTMSDFMEGLKAFDRVDPPSRKRSRRNADQVVLSQYAFPIVMSVDGYLKPPPRKTNSVANIFVSSELSAMAVLISYLFLLGLISYTSGKQADDSLYGIVELLEAISNYEDNPKSQQEDNTRIISQDEKIQKYERDRNKENKMAPTVQSIYNLETKADKPLSNINLLVPIRDTLTDCNSVETCKDTKNLLESSRFEDQINNVIEVLSQLDNNVENDGRTTDRVSDGRYYNNQVYKINDNYKKKRMPKIFRISENFDAVMIDADTFERLMNNLNTNTYNERGAKLLESINLEQLEKDNNRNVKKYNTDAGAYDAENRDDGNALVRVLKELLSKARNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G407</accession>
    <name>A0A835G407_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle control protein 50A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000570">
        <property type="protein sequence ID" value="KAF9406613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G407"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37910" checksum="DBBAA5064911B008" modified="2021-09-29" version="1">MGADELNALRNDRVPGIHDSEASNKSIMQKVTQKLLIIGAIVGITFIIFGIILISCASQSDGYEIIQDYTDCMDFKNPEMKCKDSLKAMSQVCSCFLSINVKELMKAPVTLYYELESYDDITSKYAKSRDDKQLAGQLITNTSSCGNYTYANTTNGMKLIAPCGALADAMFNDTFSMQINNTYLIGIRTGLLSEEDKKPYRNPPGDLNVALQDYAKPINWKNNVTMLDEDHPENNGFQNEAFIAWMQTNLRRKPVMRINHTGYYEQGLPAANYVIRVRYAYPEERYSGRRKIIISSFREWTNYIARNFGIAFLVLGSVTVVAVAALFYLKRREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4K8</accession>
    <name>A0A835G4K8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000664">
        <property type="protein sequence ID" value="KAF9405913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4K8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032885735" description="Cuticular protein RR-2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9405913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14556" checksum="D7A5E65B2E87645A" modified="2021-09-29" version="1">MFSKIVAFGALLAAANAGLLGHGHAVSSQSIVRHDEAHAAPLHYAAAPVAHYAAPVVAHYAAAPVAHYAAPVAHYDGHDTYAHPKYDYAYSVADPHTGDHKSQHESRDGDAVHGYYSLVQPDGSVRKVEYTADDHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4M9</accession>
    <name>A0A835G4M9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000657">
        <property type="protein sequence ID" value="KAF9405960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4M9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032384573" evidence="2">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="176" mass="19953" checksum="8CC4674CEC665973" modified="2021-09-29" version="1">MLSMLVVAALTRISCIYTMPSYENQYYSHILKVFSEDDMTPDFRELLVIQDTQESDNKKQSPASNEKNETIPLEANITTTENPANVSLPAQPQTSEESQQQDKKIPNSNDEVDVVDREDHVTQYLSDLLVNTDNEITSLQGTEVEDDREVLLPCFAPKCHSVMIAPEKPFEVEDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G566</accession>
    <name>A0A835G566_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000639">
        <property type="protein sequence ID" value="KAF9406100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G566"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF15">
        <property type="entry name" value="RE18252P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="195"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="667" mass="76693" checksum="49111879C15C3555" modified="2021-09-29" version="1">MEGTSCLNCGISSRRERRYMIAQIGPEIIHRLHQWLPQQEFSDKDFLCNQCMNALQRNLDEAESSQSQQQLGHQHVCAWCGRSILRIRSNALRENAPERILIAARISPRQLPEEPRVCYACWVAAKRNIQRNANVDVARQSIDAEESVASSSAEGNIIPQPSEQLEIQEPEVQALRTEDSNERLEFNWDDSAVLLLIEKYQENELLWNPRHMDFKNRNKRNDAVRDIASVFNIASSEIERKLKNLSSHYFREKRKYEESKRSGSGRDDVQLPKWFAYKALSFLNNKNAPSSQDNITSQTTLLSTRTSRKRNIEREPEVDEALQLLREITSNARQRDDAAIFADYISSKLRKMDHYTMCTVQHQIQNIVYEAEMRMGDVFISDRGFRDAIINLVSYNNEPHKPESLEEGETQLPTIRANKSRCVTICRWVIEVINGKFKRDYKLLRQTYFNNTCRNVMTDFRIAAALVNVFHKLITDRTDAPTILNRIRARMDVPNQLGDFIEDHNVNRRRAAFSPINGDLPQLKKKEAEQKKIEKIETKKRKDELKKQKKTTTKAQNKKSKKNNRSAKTAKQRKVSSSEDESEEEGDTPCMYCEEFKYPILPPYPLYSKYGMARTTRGSVKPGSHGLISHRPGRAGTGRQAMGTVASDVACGGLMPAVTIHRKSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G582</accession>
    <name>A0A835G582_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000480">
        <property type="protein sequence ID" value="KAF9407352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G582"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="8">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="38729" checksum="675B17D2D2D381E1" modified="2021-09-29" version="1" fragment="single">ASRLILIFFSKIPKMSRQVDIKALVSHIVRGDGLDRCRICMGDTSEGQVHLEDTVMMDGDKPLTLAEILEVITGVQMELDPALPCGLCRTCSDDTLAALTFKNLCAQSAHHWTEGSNYLSQVYPPTEEDKAYFIFYNEEKTIVKDQIDRVPTTKDAADRLNLKYTIPEPEKVRKPRQHYGSKKACKCPDCGKKFSTAEYLNYHLRNTLKRACRECRLIVPKKKLAKHLAAQHDINLYECHACSKLFADEEQMKQHVESDHGKMAYSCHHCGNSYINERALRAHAHSHSLFHCSFCNRSFENIKCYKYHRNTCEFVDRPSVQFKNFTCDHCGVTLKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5A2</accession>
    <name>A0A835G5A2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000685">
        <property type="protein sequence ID" value="KAF9405771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5A2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="18988" checksum="1224F52EC1284F5F" modified="2021-09-29" version="1">MIFNYCKTTDAYKIEYANPRFFVPLDKIYLGIAAQSSIDELSKEIPEPKTVITDFKKTCLNFYIETIKQIVQRFHFSDPLYGILDVIEPSVAQKFEVKDLSNVLKRFPSVKEQINEMELQKEWKKHAFLDHNDLAKMNYYLSIVVYVNHRHDEDLNQHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5N1</accession>
    <name>A0A835G5N1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000649">
        <property type="protein sequence ID" value="KAF9406040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5N1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033047690" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="15708" checksum="7E47E50565E5053D" modified="2021-09-29" version="1">MLRVLSITLLTIAVEQVFAQDTSKEHRELQACGGQLKSPVGTITTPNFPNPFPVPIKCKWIIEHDIVNGTISIYFTQQYTTSGLTFTEYMYYDESYKLGERRALTLTEENITRIKWLQSSVVVKIEQRGQREECRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6X3</accession>
    <name>A0A835G6X3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000345">
        <property type="protein sequence ID" value="KAF9409029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="773" mass="88686" checksum="51F3EE9054197134" modified="2021-09-29" version="1">MRSSESEPNSTAGNFLFFCSVEDKVVLVLLKKEDTRGPGPFCTSYEQSALTNQNKLELINNINERRNFVAMGHSKILPFAANMKKICGPYWSNELATSAQRWADQCDSSLYPDKEDQCRDLENVKVGQSIASILGPSPGLSVKSFVEMWFMQVVDYTGSVAYYNESQDYKTNHLTQLLWANTEYVGCGKSKFYVDERNTMVERLVCNFAPKGNAHRKPVYSVGYPGTQCRNNMKPDDKYHGLCAHEKDLTELMTQRYQSMNNLLRILNLSNESVKHEIDPIRNILGQNIANNNHSNVQRNQKTRHILPNKTNGSVKRMPHLRKQLFRNNNLMNISESNNVYHYQYDRGHSHLYHGHEAPTHNYDSTTIMNTISHFRRNEYTTEPTGPYSSTDCRKYNKFGQCTRRIRLNPENCAPHQCTKAPNECCQTTMCPSTCTEASCSNSEEPCPVPYIPLSPEPCECTHRRAPSPQSLIATTIQIYSLFYHYEIILSYDYMSRCTKPGAYQYYDLVPNAVQNGNKVPLNVLSPRTFNVENNKEIPKDQNSEHKSLSDISKDYLQNYDYIYHSLDHSGLRKQRQLKEHITVKPFWQIENPEIKLLRFTTLSNNLKTKKNRKATRVMTTTEPITVSYKNDASSNRPKHSNTEKYLSFDELMHLRKNNKTFGQTNLGARMTLLHKQQTHQNILGTHPFTGTANGNESSVGPFGSRTPPGYVDGCTRTSTCTREFMDRNEKRKVFQKIMNAFVMTITLEKREQAQYLGSHDGKNTKVSLYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7P1</accession>
    <name>A0A835G7P1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of many from the eggshell of the gypsy moth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the chorion protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000409">
        <property type="protein sequence ID" value="KAF9408077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7P1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032472363" evidence="5">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="16699" checksum="923EF49910124067" modified="2021-09-29" version="1">MSLKIFFVCISTILFEAVFSACIPPPYLREPVCPNTPIVEGLNMATVAPVAPMFGRVIGGNLIIDTSAPYTTIGPAGVMIFSDNLLIDGVVLVSGRLPFQGTVGLEGLIPTKGIGAVNYSSGNNNIGFFKESVPNQVPGMMPNGAGYPGNINNLGLGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7T6</accession>
    <name>A0A835G7T6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000402">
        <property type="protein sequence ID" value="KAF9408165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7T6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="241" mass="26905" checksum="9CDD1B28D6362A9A" modified="2021-09-29" version="1">MAEFGEVLSVLNTVLDSVTKKMAAVEAQIQNAGPCKDTVAKVAEEFRTFRELIFSILRLLRVQMSESAKQIDHLEMRHRRKALVFQGVPEADKEDTAGVVLDVLHNKLALKIEPGSIATCHRIGAVSKDHHRPILVKFTTIETKASVWRAKTRLRGTSISAKEFLTRTRQAVFARARQHFGMRICWTQDGVIHVKVPDGTRHKVTTDAELDVLLKKYPKSSGVSSMESDVGAARQLKPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8C5</accession>
    <name>A0A835G8C5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000395">
        <property type="protein sequence ID" value="KAF9408250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40408" checksum="71C359A6C7FD77EB" modified="2021-09-29" version="1">MFQIYQHLRWYTNPSEQRWIVRILFIVPIYGCYSWISLLFFNGNSYYVYFFTVRDCYEAFVIYSFLSLCYEYLGGEGNIMSELRGRPVRASCVNGTCCLSGATYTIGFLRFCKQATLQFCLIKPVCAFIIIFLQARGLYHDGDWSPDGGYIYITIVYNFSVSLALYGLFLFLGATREMLKPFDPVLKFFTVKSVIFLSFWQGVALAILEKAEVISPFHDANGVPTTAGTVSAGYQNFLICLEMLAAAIALRYAFPAAVYAHAHRDPHRSVTMQSISSSLKETMNPKDIMTDAFHNFHPQYQQYTQYSSVMRAGAGAGKREEGGALAPRPPPQRVATISHATNYHEKTTLLSSDDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9J0</accession>
    <name>A0A835G9J0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000244">
        <property type="protein sequence ID" value="KAF9410831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="45"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="425"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="568" mass="64437" checksum="D114C9179B758C07" modified="2021-09-29" version="1">MAMETLDVAEKAELALLEKQKPMNEVIHRGDSPVQQFYKGTTVFLTGGSGFLGKQFIEKIFRACEVKRIYVLLRSRKGKTISQRLTYILSDPLYDGLRKIKPNFANDIVPIEGDIADIRLGLCDKDWDTLTKEVNVIIHLAATVRFNEPLKMAGLINVRGTREVLELGKQCLNLKLLNHISTAFAHTTVSRIKKDVMEQFYPAPVPPDTFIELVESVDEERLAEITSGLIKGWPNTYTFTKAIAEELVRRRAGDMPICIVKPAVGLSAHLLEHNNVTLAYFLKFHHIHSHVWFSVIGSYVEPSPGWIDNQTIMASPVGFLLGSGLGLMHVLYLRKELDFCIAPVDYVNNAILAAGWDSVQNRKIIDNEIPIYTVGSSACNYSWGKLIETIKSDEMRKMISPKSLYYACAVETSNPILFWLLTWIFHYIPAYFIDAIVSILGVRPKGLPSLVSIYTKTYNLFKIYEYFLFNSWKIRDDNLVGMMDRMSPEDQAIFGCDVREIDHRDVAISMSIGLRRFIVKDGLKGSEYGHKKQKILKYVNILCLALYGYLIYSLLSTIYSAFSIFIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Q5</accession>
    <name>A0A835G9Q5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine-5'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000251">
        <property type="protein sequence ID" value="KAF9410698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Q5"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23365" checksum="117A79766CF7FD28" modified="2021-09-29" version="1">MLKEICARHGKRYTADLEAKYTGGTDKEICTNLVKELHMNCSADKLEAELRELSRVKLPHAPLQKGAERLLKHLHATGVSFALATNSTRRAVRLHIAAKPKIFALFHHMVCAGDPDVDRGKPHPDIYLMAAAKFPDKPKPVKCLVFEDSLVGMEAGLAAGMQVVMTPPKHIPPQQTRKATLVLKSLQDFRPEYFGLPPFQDNIKGKPMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9T3</accession>
    <name>A0A835G9T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000282">
        <property type="protein sequence ID" value="KAF9410017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="177" mass="19579" checksum="E69815C72D001C1F" modified="2021-09-29" version="1" fragment="single">SHSSDPPIPMGHPLWLGTEPAYEPNGVEANEPEAKRFRATERFTGRCNFCGISGHRFAECRKRRDALGSVEPRDTPSTSRPLERKNDVTCYTCGQIDHVTTNCPDKRNGGKAAAKEVHQCEHRPSRGNLTTSSGNYRVVERSERTCLPQDGAHSIAPAHCGALCHPILCRRNFFGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAH2</accession>
    <name>A0A835GAH2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromatin-remodeling complex ATPase chain Iswi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_009491</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000212">
        <property type="protein sequence ID" value="KAF9411794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAH2"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="143"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="438"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="798"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="972"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9411794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118728" checksum="A52E5653A070F588" modified="2021-09-29" version="1">MSQTEEPMDVADVGENSNGSSSDTTSSRGKEGDFESKIETDRSKRFEFLLKQTEIFSHFMTNTPKSGASPPKPKAGRPKKIKLEESGSAGDHRHRKTEQEEDEELLAETNTKVKSIFRFEASPPYIKNGEMRDYQVRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYMKNFKNVPGPHIVIVPKSTLTNWMNEFKKWCPSLRAVCLIGDQETRNTFIREVLMPGNWDVCITSYEMIIRERSVFKKFNWRYMVIDEAHRIKNEKSKLSELLREFKSMNRLLLTGTPLQNNLHELWALLNFLLPDVFNSSDDFDSWFNTNAALGDNQLVSRLHAVLRPFLLRRLKSEVERKLKPKKEVKVYVGLSKMQREWYTKVLMKDIDVVNGAGKVEKMRLQNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVNNCGKLAILDKLLPKLREQDSRVLIFSQMTRMLDILEDYCLWRQYKYCRLDGQTPHEDRNRQIEEYNAEGSEKFVFMLSTRAGGLGINLTSADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITENTVEEKIVERAEVKLRLDKLVIQSGRLVDIKSQLNKDEMLNMIRHGANHVFSSKDSEITEEDIDVILAKGEHKTEELKQKLESLGESSLRAFSMDTPGATTDSVYQFEGEDYREKQKVLPIGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKVQAPRPPKQPIVQDFQFFPPRLFELLDQEIYHYRKTLGYKVPRNPELGPDAAKIQREEQRKIDDAEALTEEEIQEKEQLLTQGFTNWTKRDFNQFIKANEKYGRDDIENIAKDVEGKTPEEVMEYSAVFWDRCHELQDIDRIMGQIERGEAKIQRRASIKKALDAKMARYRAPFHQLRISYGTNKGKNYVEEEDRFLVCMLHKLGFDKENVYEELRASVHAAPQFRFDWFLKSRTAVELQRRCNTLITLIERENQELEEKERAEKKKKSGAANQNTPGGNATGKGANTSKRKADNTPDTAQKHKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAM1</accession>
    <name>A0A835GAM1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_008694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAM1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="223" mass="25402" checksum="5DAF8ADB1B7F6CED" modified="2021-09-29" version="1">MSDEDMTGDAKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEEERVVSTERGMQLAEQLGVEFYETSAKENIYVKAVFERLVDIICDKMSESLDSEPAMLAGGARGQRLTEQPQGNSTTNCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBP7</accession>
    <name>A0A835GBP7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_003167</name>
        <name evidence="9" type="ORF">HW555_008932</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000183">
        <property type="protein sequence ID" value="KAF9412620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000543">
        <property type="protein sequence ID" value="KAH9635553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBP7"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9412620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9635553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="108" mass="12122" checksum="BE31F20D9F6AA4E4" modified="2021-09-29" version="1">MPKHKKQESSSSSDSDEGPVDRNPPAEKKAKTGNSTRTADKEPTWVLQGKKLVKVREFKGKVYVDIREFYEKNGDLLPGKKGISMTPEQWKKLLSLGDEINETLSSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBW4</accession>
    <name>A0A835GBW4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_009098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBW4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="249"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9412429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="930" mass="104443" checksum="B7379AF1DA12DFE0" modified="2021-09-29" version="1">MPKEQYRETYVGRKISHVTFNVDSPAAIQQAAHIQVITKNLYAQDGQRVPAPYGVLDRRMGTNQKDANCDTCGLGLAECVGHYGYIHLALPVFHVGYFRSIITILQTICKNCSRVMLAEPLRRAYRRKFMNPELSYLQKKNLRAAVHKKAKACTKCPNCDSLNGMVKKSPAGILKIIHDKYRTKKPTDAVVKRVLKDFHEAKESNKELTTMINSGLIVEMSPVEVLDIFRRIPDDDIPLLGMNGLTRPEHLILTRLPVPPLCIRPSVVSDIKAGTNEDDLTMKQSEILLINDVISRHIASGGKSELVQEDWDYLQLHVALYINSEMSGIPLSMQPKKPGRGLVQRLKGKQGRFRGNLSGKRVDFSSRTVISPDPNLQIQEVGVPVHVAKILTYPERVFPANLQWLRKLVCNGPDVHPGANYVQQRGLKHKKYLKYGNREKIAQELKCGDIVERHLVDGDVVLFNRQPSLHKLSIMCHRARVQPQRTFRFNECVCTPYNADFDGDEMNMHLPQTEEARAEALILMGNKSNLVTPRNGELLIAATQDFITGGYLMTQRDTFFTKDEASQLAACLLAGPDATMRIDMPPPAILKPRKLWTGKQIFSLIMKPNKKCEVKANLETKGKNYTGNKDMCVQDSYVIIRNSELLCGSMDKSTLGSGTKNSIFYILLRDWGEEYAVRGMWRLARMASYYMMNRGFSFGIIDVTPGKKLIEAKNKLLEAGYSKCDGYILEMEKGTLQCQPGCTMEETLEAVMLSELSSIRELAAKACFRELHPTNAPLIMAQSGSKGSNINISQMIACVGQQALNGKRVPNGFEDRSLPHFERHSKIPAARGFVENSFYSGLTPTEFFFHTMGGREGLVDTAVKTAETGYLQRRLVKSLEDLVLHYDMTVRNAMGEVVEFRYGSDGLDPSYMEGKDRPVDLARVLADVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBY0</accession>
    <name>A0A835GBY0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000236">
        <property type="protein sequence ID" value="KAF9411065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="375" mass="40510" checksum="07E7F9F90EC31B8D" modified="2021-09-29" version="1">MCPKNIFPSLKNNLSAICAIESPVRAQRAITQRARACGVLETVHLRASVFVSQVELPYKKAAVKRARESPPPTGLVTPQPSDSEGEDDFSKRSRCELARLLLTTPPPEPCCRPSVIMRAHKDGTCSPEPLVPPPQQDNMNILKTLKFKMNRGHSYSQAKYIASQAQVVPPIQVEPPSPPPKAEEARVPSPHPECVPKHERARRAARAVPGRGPGLGAAGAAARARRARARHAAAHRGAVAGGARPGRAPPPLRVLVSRLREELLQVIPPESSRQNPHRRAAVPLRLGWVRASVLALGRAVPAQAHAYWGEEVRVSRVQPPLHALRPPRQAREETRQGARAPGARAQAAAVAAARHTGAGLRRARALTLCATTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC27</accession>
    <name>A0A835GC27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008695</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="78"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="462" mass="53946" checksum="5420083502B9CC64" modified="2021-09-29" version="1">MLRESVLNVVCAGVQYFLFIFYVMKFLIMTAMCFYVKTVLTLDCYWNSGCKYKYFSSKTPYEIVRGDIRDSIVKQEGCETISVWSIFRHGKRNPSSKYATDIQYILKYYKDFIVSSFEIGNSSLCAQDVENIKNWKIDTKMLDEPNEISSEGYRELFDIGSRIKETFPELLSKLQENEYKFQPAFGSRIEESARAFAEGLDDCNLLITKIYGDYTYVAPYSICGKYQIDIRNNPNVYHEAEVYENTEEYSNMRERVAKNLGLNFVPSSDNITAIYDLCRYSWNGILHQPSPWCAVFTAEDLKILEYVGDLRHYYRNGYGASQFSNTLGQLPLSDLLRNFEQSKRGNGKKIVSYFTHATMMDMIVVVLNLYRDPTPLLGSYRDLNRQYRSTFLSTFSSNLIAVLNRCRKAHTYDYSVSFYWNEKPLKELCNEGTCSWQEFENIFKPFLNATDDICEFKWTKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCA1</accession>
    <name>A0A835GCA1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000212">
        <property type="protein sequence ID" value="KAF9411807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCA1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032456633" description="ER membrane protein complex subunit 10" evidence="9">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="23335" checksum="FDB0608EF12C83CA" modified="2021-09-29" version="1">MHLQSFAVILSLGLVNYAACIDYDGWLNIKIEHSLNCGTEKYCPRGNIALKSIRAGAAVVDQIHFNKGHIEALKNLAEIDSFYTIRTLVTSAENSKGTEFFSSVKARAFLGNGLSEFFSVSFQVTNASQPLSLESGTQKINSNFYLRYVAMPDTATYIQKLEREREAREKGDLKDNKSFLAKYWMYIVPIAIFVMISGASNPEPAAQGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCE3</accession>
    <name>A0A835GCE3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCE3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="27358" checksum="F4B8F4A53B2E40A1" modified="2021-09-29" version="1">MAEIIRTEIRSAISTEFTLFREQLSNFEASMQYFSDEYDKITTTLKTITDENTHMRNENNSLQNKMKDMESRLAHMEQEARQNNLEINCLPEHKNENLIKTIVQIGSAVSFPIAESEILSCTRVQKSNPASKKPKAVICKLSSKAHRDNLLGAIQIYNRKNPKNKLNTKLIGYGDTESPVYVSEHLTPANKSLHAATRIAAKEKNYKYVWVRNGKIFIRKDETATSQIITHRDILKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCH1</accession>
    <name>A0A835GCH1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCH1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="26801" checksum="95947A00B679A60A" modified="2021-09-29" version="1" fragment="single">MVNSSLTKFCIQDLIPGSTKTSGKKVDVDAILPYLIVPGLLLIGSISRTITITVMVVIAMGALYVHSRPRQKNRSPFFFSWTISSGLYMFLVFENGILCFLEITMLENSIFLLLFLCTLYFFYKMKSIAEYELTGTGTKGKEYRWDCCVLRPNYLHFLAGHTFALATLLLGTNLGLTTVCQPFIFYGAILMPFDCDDIYYDFKMAICFVTSIYALGYALVVALVLIRQLIVYLPKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCM3</accession>
    <name>A0A835GCM3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000132">
        <property type="protein sequence ID" value="KAF9414485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="252" mass="27854" checksum="CE7D1F96D2B973B6" modified="2021-09-29" version="1">MSNGEVSVVNGGSAWLSPAAILKKFGAKKGRIPRSGDLDGIPPPSPLQGDPEVNPLFLGEVPLEPTFSLRISSAQRCCHLCVDTRVTCNGRAAPRNSVDKTNQCSVRRMNKLGVIYLSSRLLKKYVKLVRSSIEVMSVTSLTEAQRKALSYHTWPHYKVLLGITPAWILERHVLEGFRKHERFTEKSLIKSIQKQSTTCSMHHKVVIIKITAINCIGSIGSIYTLVQEAQIFVKKDGSGTMRIDRERTAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD18</accession>
    <name>A0A835GD18_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000126">
        <property type="protein sequence ID" value="KAF9414743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="323"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="693" mass="77993" checksum="3DFD43DBD273A56B" modified="2021-09-29" version="1" fragment="single">DHQSAVLTSSILSGKLLPLVSGSNRATRPAITGVVPNMAVGSQGIVVDVLEMKGAAIEPILIAVEHAPIPIFLSTVGCSDGGTAHSQSAKREGHSEDLGHKVKDHDEDSLHDEGYGNEYNKIITIFISYLIKIVFETGASSSQSYADEGIRTGLADVLVKPKEDDTSDHPHDAAAHSLQQQAAFEQVQVVWLGLISFSGDLLRHLCQGIWNKHPVTSRYLGPTASMTITKDTTIVPDVARPVRNRSMIYLMDFKRIDCYNLPLPLPGVADQNQNFSESAENAILSEAADETEGDWMEGPFVPETLPSTRPSPGTLIPGNASMTPIQYWEVFFNSSFLTTLATMTNEHASRIITGLVKPESRLKRWKPTNATELKTFLGILFFMLTVVLSGKYMSRDRFLIILRMLYFKYESKEIEHPYEKVNSLIEYFNNTMKNSVYPERELTIDGSWVLIKGRQTRRQYKRHNFIKLHVLADPKGLVHRINMNKRPANSEVSGTEHAKKVVLKLVEDYLNAGHSLYMDDTYNSVDLAESLLRQNTYCTGTLRSKTRGNPVSVISKRLTSGKKMKKVYLCVMKWKGSRKVLALSTEHKPDILSKPEIIDKYNKFIKGVDRHEQMLSNYPFEHKTKWYKKVGIHIMQMMFVNSFVMFKESTGKIISLDKYRDEILRFLLPPAPETVSVSPTHMPKEVDRDSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE40</accession>
    <name>A0A835GE40_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000144">
        <property type="protein sequence ID" value="KAF9414055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE40"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="484" mass="56078" checksum="1C49136A53C566DA" modified="2021-09-29" version="1">MVDSKELFNDNFESRSASISSNKSVAEQDIEEQFNMDVITNEEMIRPKKRDREEEEEGWVQSKGKKTKENCIEIYISSKEKLPRQFALARLFKEKDITDIIKVKYLNNYRVRIDCKNELSATKLQTCKDFMDMDWRFSRPDFKSYSYGVIKDVDLDLSDEQLMSCITCPENFELVSLKRLQRRSNNDSPEGLWVTSEAVRLCFKGDMLPGYIYADSLRINVEPFVFPVSQCSRCWKFGHTVRVCPSKKTLCPKCGSNHANCDTQHFKCLNCEGPHMALSKTCPAFVKEKNLKSLMAEFNCTYRKALQLYVAPSPRRDEKEFNKSSPTDGVFPKLKTKLTPTFVTSDDQASFVKSPSSPLYAEVVKTEATIHKARTHIDQQRTKKHEKTRVDKGNDWANWLPTETGETKELEHDPEDSKKKEVNFDELLTRLKNILFLKRCTVGEKIRMAIQCCLEWLILVVVDNVSDWNIVKKLFELFNGQTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE94</accession>
    <name>A0A835GE94_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000180">
        <property type="protein sequence ID" value="KAF9412715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE94"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="702"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9412715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1067" mass="122632" checksum="C95DCBCA2FAAB68A" modified="2021-09-29" version="1">MYSKSYETTKDSFLEQAKAAREERAFEKKREQSATRIQAVVRGWLERKKFVIRILNDFDGLLPESTSHGSQEEPPQPVELIPALEVYRVTCRLFLVFKQQRDRKRFENLCKYIVQSLHSESVKLSYVGVFLNKEYSLRWIAHIKDLLYKCCQYLEELKPESPIDMQSILIHLHTLVAFTANNTWALTRLKNFEKLRGGMTQLCANVMGSLFHRGYYLTLKSLLLRGLCREKVYLKNISLTAIVTLSLRPLVSAQFSEKLLTMYIIQILSVPTLVYHMQLISPESMSSYRSYSMFDKCLEFLSTDQNMRIVFNTLEGNYALCLLANLVQMAHCERDHAQPETYHPTFVLVVTRFLDSCQQYVVCKKGNLSNWHPILGWFSQGLDNFLPPAMGNLRNQLSLLWGAPLLKKLLATPLKDMMDAGVTGEEGAGPSQPSTPIQSNNPAAIIRRAIEARTNRSNANKHYRKLGSPDCTKTALICSMYHTALQTMTQVKLDILTGLCNQDEILYSLWQFLCTLGPNCGLKSFLDLLAVNTKTSAPEFQMILDDMEMYEQQNPFKLQDFINMSQFLNMFVYKSIMGQLFDLKTIQSNELFSSLHTLLLVLYRRDCRRAYTPANHWLVREIREGQFMADLEKGKKPQQVLVQKTPHMIAHGERVRLFRRAVADEKVVLGLTERACGGRSTLVTVRRARLVEDGYRQLAALPSRALKGCVRVRFINEQGLDEAGIDQDGVFKEFLEETIKRVFDPSLNLFRVTSEERLYPSPTSCLQENHLQLFEFIGRMLGKAVYEGIVVDVPFASFFLSQVLGQTQQALYSWIDELPSLDRDLYRSLTYIKHFQGDISSLELTFSVDEERLGEIVTHELVPGGKAVPVTNENKINYIHLMAHFRMHTQIKDQTNAFIKGFRTIINPEWLSLFSTPELQRLISGDNVPLDLRDLRRHTQYYGGFHDSHRVVCWLWDVLQRDFSEHERGMFLKFVTSCSKPPVLGFAHLKPPFSIRCVEVGDDEDTGDTIGSVIRGFFTIRKKDPLNRLPTSSTCFNLLKLPNYQKRSTLRDKLRYAVNSNTGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEC9</accession>
    <name>A0A835GEC9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000164">
        <property type="protein sequence ID" value="KAF9413309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEC9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="77327" checksum="89AD7AE0DCD3B40C" modified="2021-09-29" version="1">MWDIKNKIFLITGGASGLGAEYAKACLEHGAKNVAIIDIAEDLGKAKAESLNKAYGNKVIFVKCDVSKEEDIESAWDAVLAQFKQVDVIINNAGIMVDAPNMWRTASDVNWQGVVSFTLKGVSHMRKDEGGAGGTILNVASILGLSKLTFLPIYSGSKIAVVHFSQCLTMDPFYENTGVRVLTMCLGCTDTPLVQNLETKSWDPKLGDEIVVNVANNYIRQKKESAVAALIKMLVNGNPGSIWLSLDDKPARDITSAMDNNVAILDIAEDLGKAKAESLNKAYGNKVIFVKCDVSKEEDIVSAWDAVLAQFKQVDVIINNAGIMVDAPNMWRTASDVNWQGLVSFSLKGIKHMKKNEGGAGGTIVNIASTVTLTKLVAFPIYSGSKMAVLHFSQCIAMPPFFEHTGVRVLTLCLGLTDTALLENLVTKAYDPKIGQFMMAFAESQNVMYQKPESAVKVLVHMYKCGPPGSVWLSSVAILDIAVETGTATVERLNKSYGNKVIFVKCDVSKEEDIVSAWDAVLAQFKQVDVIINNAGIMVDTLNMWRTASDVNWQGLVSFTMKGISHMRKDEGGAGGTIINISSTAALGKPGALPIYSGSKMAVLHFGQCLTMEPFYDLTGIRILTKCLGATDTPLLHNLEAKAYDPKVGRLLVQTVETQGIIFQKPESAVAASLYMFQNGAPGSVWLANNNKPAKDITPIIDSAYAEFDKVMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFI5</accession>
    <name>A0A835GFI5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032944950" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="262" mass="29221" checksum="243D2FB08ACBA2C7" modified="2021-09-29" version="1">MNYLKLILLVIYVNFACARRIERSRNETSYHDSSDASSIGKSACHYSDPNVAECIQRIAEQARQLLAQGVPSLNIQPLEPLKIPSIRLRQHNMPQNSFKYDAWLSDVALEGLTNYTFNKLDVYPEEMKVTANISLPHLMMSGDYVVLGDFQMLPVESTGKMAANFTQCTAALEALGARVHKRMVIRDASVHLKCTGPLKASLMEAHSTTGEMEMITDHIAQMHSMDIAKEVQPAVETALAMVLEDVANKFLKHIPPDMVFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFW3</accession>
    <name>A0A835GFW3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_013998</name>
        <name evidence="3" type="ORF">HW555_006577</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000377">
        <property type="protein sequence ID" value="KAH9638726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFW3"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01820">
        <property type="entry name" value="PAF_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9638726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="225" mass="25691" checksum="D10B30E89AC0E7C6" modified="2021-09-29" version="1">MNPCSVAAPQQDTEGDGRWYSIHNRFLSDAKGKDGDVIFIGDSILQALEHTEVWNQWFAPLHCLNFSIHKDQTQNVLWRIKNGELDHVDPKVIVVHVGTNNVEYTAEQVCDGILEIIRTIREKHPSAYIVLPSLLPRGQYPNMLREKNSTINQLLREKVSNMNKVEMVSIDKGFIQTDGTISHHDMHDYLTPTNAACRKAFEPIYDLLQQILFEGEPEKDLTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG26</accession>
    <name>A0A835GG26_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000103">
        <property type="protein sequence ID" value="KAF9415730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG26"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="49" mass="5176" checksum="7D4881239F62F2AC" modified="2021-09-29" version="1">MLLEIYFLLLFTVRVADLIIVLASILSSGLANVLASDLVGVLDSVLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGB5</accession>
    <name>A0A835GGB5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">HW555_007349</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="36">BAW_Kor-Di-RS1</strain>
            <tissue evidence="36">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGB5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KAF9414880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="36661" checksum="DFAFCDDC3437870E" modified="2021-09-29" version="1">MVKARKYVVKKHFEGFPKREDYEIVEYELPPLKNGEILVKVEWVSVDPYMRAYNSRYPTPYDQFGFQVGLVEDSKDPRYPVGTRVVSHKGWCDYCIIDTTDTSVGPTGQPYKLPNLKGLSNSLGVGAVGMPGLTAYFGFLEICKPKAGETVVVTGAAGAVGSLVGQIAKLKGCKVIGFAGSDDKVKWLEEIGFDKAINYKTADIAAALKEAAPKGVDCYFDNVGGELSSTIINQMNDFGRVSVCGAISAYNDSNLPKATILQPALVFKQLKIEGFLVWRWFNRQNDAFADLIKWIQNGDLKPREHITEGFDNIFDAFIGMLNGENSGKAVIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGX2</accession>
    <name>A0A835GGX2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_001361</name>
        <name evidence="11" type="ORF">HW555_007060</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9634159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGX2"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20514">
        <property type="entry name" value="CYCLIN_CCNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000015">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000017">
        <property type="entry name" value="Putative cyclin-c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="158"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9634159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="31536" checksum="99FF3D55EFB5A3CC" modified="2021-09-29" version="1">MAGNFWQSSHHQQWILDKQDLIRDRQHDLGILSEEEYQKIFNFFASIIQVLGEQLKLRQQVIATATVYFKRFYARNSLKCIDPLLLAPTCVFLASKVEEFGVISNSRLITTCQTVIKNKFSYAYGQQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLLFVQDIGQDDQLLTYAWRIVNDSLRTDVSLLYPPYQIAIAALHIACVMLNKENHKPWFAELNVDMDKIQEIVRSIINLYEMWKSYDEKKEIQALLVKMPKPKPAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI11</accession>
    <name>A0A835GI11_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI11"/>
    <dbReference type="OrthoDB" id="6620433at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF13">
        <property type="entry name" value="HDC01644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032953826" description="Cuticular protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16555" checksum="DEF30D78E5CFB626" modified="2021-09-29" version="1">MIAFKTAAILLLAAFAAARPSEDWEPEGHSHSEHTKPYHVTVVKKIGVPVPHPVAVSVPQYVKVPIPQPYPVHVTVEQPIHVPVYKVVPQIVEKPVPYTVEKPVPYEVEKPYPVEVEKKVEVPIPKPYPVHVPVYKHVYHHKGGHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI64</accession>
    <name>A0A835GI64_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_006292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI64"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="14">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9416338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="46795" checksum="D1F172858F05061B" modified="2021-09-29" version="1">MTDALCHLVVDGNEVLEFKLVREIEDLENDETSFGPEMCHQVFGENENIFGYTDLHIKLFYSAGSLQTYLGIEYTEKIEPNKSEGMKADDVEGALTKVIAPGFTTNLDHFVSKLKKDETFVPYGKLIHAFQATPSDGGDKRSFEVYYSETSTSGFLDYHQRLQTFLLWYIDAASFIDVDDDQWTFFTVYEKFQSSEGGTRYATAAYATVYRYYAYPRHSRPRISQVLTLPPFRKLGICANLLEAIYANFMIQPDVVDITVEDPSQDFQRIRDYVDAASCENLPAFHPSKLVQGFSQDMAVQACNKFKINKKQARRIYEILRLKNTNTSDKTAYLNYRLEVKNRLNAPFQKKKLEMKKLQKVLKPEEYAATISATGLSETHGRLASQYLALEQEYRRVINRMERNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI74</accession>
    <name>A0A835GI74_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="447"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="67920" checksum="18077BC20414DA26" modified="2021-09-29" version="1" fragment="single">VQSVTLSNILLNILPNELSTNNNVIVCCHRCATTLRRGRTPTQAFWNGKWNDEIPPELKILSNVETRLLTRIIPFVKMVKLTGRFEQHDVDEIAEQLPLRMSSAGLVIVCNQLDSVQKLRGFSVNIPNLRAWLMSNNPIYANVGNDRRILRGSFNQSHSKFNDFPRGKQCTANAAVAIAVLKIKSAETLSSDIIDSILISGDRYTSSIQSRNAPNLVFGWSYLQPNFEVAKGRVAQNGAACLISFTEITALWAVLKSNIPKSQENRLDDDHNSIIKIRPEVYTKINEPDYDTDIGSHLSSQSPSDLNNDNIVITSSVLRVIDEPILELSTVIANDNCSELPVHQLRRKTEPPSQITRERRAEELSWFYLELIHDFKEMTIFLCIIGNGVLLSKAKRWCSVKNAPGRKSGRQFSRKHSSKYAAYARLKCLFAKSMFKSHCYCKIFRQKLVNDHPVTLSRHFMIRVNAFMRLLKNDDKIFGRKLTDFWWRIKFQNSGSPHLHMLFWIKNASNFDTFEGRSLISEIYLSDETVLLGPDETLRNNGRFCTLRQHSDEQYVNNYNTPILKLWKGNMDIQSCGNVTAISYCIAKYTSKHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI79</accession>
    <name>A0A835GI79_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI79"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66785" checksum="A7118595235A0D14" modified="2021-09-29" version="1" fragment="single">MDDIYGKTKIMYENTKADMVKLLQAAEENVKFDLSDLSAGEADEKTKTLLTQQECNFKAIDRAMGKIDFDNVSEKWELDDYLAILKSKWERIDSTHWELEALLKGSKNSYNEMFNSMEAKYDEARKLLKSKMWSTAHHQQSAPKIEIPEFSGHYNKWISFKDLFLETIHKNPTLNKAQKMQHLKTKLKGEAERLVQHLSISADNYSSCWAILTQRYDNRRLQFSSFMNTMLQLPVIHKPDAYNLKKLHDVTTECLNGLTNIGFDITSWDPMIVHLMAQKLDCGTFNEYIKSLQDNREVPTLQEFLTFLENQFTAFETMKSSKKESQSAEKAAGTEKHASRNYEHKKWQLKTYHTSYGQCPLCKNNHVLMRCPQFIDSDTKQRNSIVAKLRLCKNCLFRHENETCNSVKTCKECNMNHHTLLHYNKSHNKIANSTSTENQRSGQRPSKETGTASSNHLSANNMEVLLTTVQVKVMTVDGTYINLRALVDQGSQVNLITENAAQLLRLPRNKLTAKISGVGSVSGDCKGQLSITCKSIHSDSLTKTIRIVAWIRRFLGNARNSTKRDTVCLSFCELSNAEELIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIC9</accession>
    <name>A0A835GIC9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIC9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="180" mass="20594" checksum="7DBC5EC9312A1616" modified="2021-09-29" version="1">MAISWMSSLCTFPPATMTRSNDVKSQFFSCFNRDSNNDGPTRALIGWKKDLPLLLQPQHPGFMLESRYLQHTTCATSTDEPQKIKHGQFQIAEWMVRVEKDDEKKEWIKSSTAMTTSTMHSSTITYFLNEGKISYSFRSERGKLTIYEFDKESAGCPRLQTGEDRVLALSFSLSRRGSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIQ9</accession>
    <name>A0A835GIQ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="74"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="280" mass="32009" checksum="B017009C51DBC45A" modified="2021-09-29" version="1">MIPAKLKSCLLRPDTGPCRADILSWYFDAKQEKCYRFFWGGCQGNGNRYTSRSECFNSCYVNTSLAKAKVPHFCSLAFEYGDCFGHYNRWGWDPILKSCKRRLYSGCGGNQNNFETKMECLATCVTGPNSSLTKRKVCLLRPDTGPCRADILSWYYDAKKQKCYRFFWGGCQGNGNNFISEAECKEECFLSTKMKTAHTPYFCQLAFDFGTCFGQYNRWTWDHIAGHCRRRLYSGCGGNQNNFETKEECMANCMSKPNNTLNAAHSQLTTCIPFSIAEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJQ8</accession>
    <name>A0A835GJQ8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="44748" checksum="43BBE6C6F51B0EEC" modified="2021-09-29" version="1">MSALKCVVEGCNLEYDVVCSFSFYNANISTDNENKRQDWIEGAMHEESECLWRHVSLQLCGYHFELDNQGLWIDSPMLPELLTHQEKAAPVIQSPNDKKLAEIIRMEHNYSVEPVKEDPESVSRLNVRQLVDTLGYLSLKNLQRKQLWVVKVETDKAEASITQSEQVITKMPDPRQIIEIIPQTSTSTATEPEAQNSEVLQIMDDTTISDNFIYEIAEEQEITMEEVKEIPASSSENPEWTVNILPDDTKPKYAYIKHCASGKKKRHFTADMNEITLQGDFENYYILPDVDPSVGVEITTSYEPENYIVEEYQHLVLDERPKKRSKDDSGRKKKKRLSNPPVKEEPTDWVVDNNIVYEQDEDFDDPKKVASRVRRKNKKYLGYDFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJV9</accession>
    <name>A0A835GJV9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_010879</name>
        <name evidence="7" type="ORF">HW555_006110</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000646">
        <property type="protein sequence ID" value="KAH9633641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJV9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9633641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="212" mass="24535" checksum="E0787D617AA55949" modified="2021-09-29" version="1">MPKKLFYFNLNGLAEPIRYILHYTNQKFEDIRYDVYTWPDPKIKATLPYGQFPVYEEDGRILTQSLAITKYVARGTDLVPTDPWDNAVIESTLFSILDYWKNVVPSVREADPVKHAELRKNLLEQSIPYFFSRFNKHLEDNGGFLNGKLSWGDFVFCGVIEASDLFLGIELGKDYPAVGNLVKHIRNLPGVKEYVKANGPFTIDLERFKYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJZ3</accession>
    <name>A0A835GJZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCY1-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71133" checksum="7DE49EF47D530D57" modified="2021-09-29" version="1">MWQLDQQVIQVLPRVPSALQEAVQRLLARDPHPRPTTQLLPLIKYFKNKGDQEQAIAAMQFLDVVTMKDPNQKAHFYRTTLIEALPSIPKTEVRTAEVLASVLQSVMWMVKEADEEEFELYIMPTLKALFNSPRSIQASVTILENMHTIMLKCNQTEIDQEVLPMLYHALESNTTQIQAASLVATQNICDSIDNKALHTELLNKVKSLLERNASDVKIISLILCFYEKIIVKFDRTLILEQVIPTLLAMRLSDPDIVTRVVKLYKSLLMERKFGLTTNVMATKMIPSLAPQTVNPALNVDQFTNLMEVYFLRILFNFEVYSRFVGNKNKLTMCLLRRTAQILYDMLENIDRQQRYKLKADNLALPSPERRKLRHQMSTDNMNAPPFNIPNLRVDQRKTSSAEDMARKNSMSGPPPAAVPSTSGSVGGFKSKHTFTKCSVKSPTRTRVIRKFCTGTGIGQWFFGSSNSTNTDNNFLRVSSAFPNRRLSDNTLMTPKIRIAPSCASSPGGTPGGTSGLPTRRHSSIGPQERRGSAVNLSPPTGGSMPNTSSSVPFLLTSSMQSIRSRRPSACLSGSQGSGLLQQISSGMVRHLPSSSRHHSHASTSTNWSLQGATAAGYNALQHTAMAVRKCPSLNITLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK71</accession>
    <name>A0A835GK71_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK71"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008075">
        <property type="entry name" value="LIMR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625">
        <property type="entry name" value="LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625:SF0">
        <property type="entry name" value="PROTEIN LILIPOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01692">
        <property type="entry name" value="LIPOCALINIMR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="484" mass="54081" checksum="54943862D612C99E" modified="2021-09-29" version="1" fragment="single">IFLLLFILLYLVSFMLIEKFRRRDSEDYFTGDEDEVKVYRISLWLCTFALAVSLGSALLLPVSIVSNEVLILYPNSYYVKWLNSSLIQGLWNHVFLFSNLSMFVFLPFAYLFSESSGFPGCRGLKGRVYETFIVLALLGVAMLGLAYVISAWLEGDSSSIDALLNLWTYLPFLYSCVSFVGVLMLLVFTPLGFVRLFGVVGGVLVKPQFLRDLNEEYYVYSFEEDTIRRRINNAVSTGVGYISPEPMYPDRGDISAPLDADVSISKDSQRAAVKRGKETPLLRLRNGALQAGLNDRLHRVVAMRKEVEGQRKTSSLQRNVVYPLAMLLLLALTTITVLMVLQNTLELLIGIKALPLTIHAGHCVAVEAGVCGRGAGGVPDRITNFDLLGEFGRIEWLGNFKLVLLYNAIFAGTVTLCLVSKFTASVRRELYNRFRRIADVFTFPEETKTKVITKAALNATRASVERSPAAENMVNVDTEDAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKI0</accession>
    <name>A0A835GKI0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKI0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="74" mass="8818" checksum="ED4A9214E224C33D" modified="2021-09-29" version="1">MGKRKDDDEPVEVDITTNQQKRTKDLVPQENEEDIKDEDIDKFCDELNEEDNEQFESWVKLIEAKLHSNKKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLG4</accession>
    <name>A0A835GLG4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glutathione synthetase</fullName>
            <shortName evidence="15">GSH-S</shortName>
            <ecNumber evidence="4 15">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_003240</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:189406"/>
            <dbReference type="ChEBI" id="CHEBI:189750"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4 15"/>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLG4"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000141">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="18">
        <location>
            <begin position="174"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9420490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="50852" checksum="B8248D7DA166EEDA" modified="2021-09-29" version="1">MHGVAMRDKKHFNKDVIQVAPFVLLPSPFPRTEFEKAVELQPILNELMHKVAHNNEFLEHTLQNALQVDEFTKNLYDIWVKVRNEVITQSVSLGLFRSDYLMQNKEHNKIKQVEFNTVASSFGAMTSFLPTMSRYILRQLGHPELIKNMPENKALSGLCSGITDAYDLFGVPDAVVLFVVEEVSYNICDQRFHEFEIAEKRPDIMIHRKTLNEIYEETTLNDKKQLILDGRPVAVVYYRSGYEPAQYPSQREWDARLRVERSTAIKCPSIQYQLAGTKKVQQALASPGVLEKFMGSGANTARVRDIFTGLYSLDFDENGERAVEMGLKDAEKFVLKPQREGGGHNVYGAEVREALQRMRHSRERAAYILMERILPPLVQGYVIRPGAAMPPPVVDLVSELGIFGVIIGTSDKIFHNRQVGHMLRTKLADADEGGVAAGLGALDSPYLVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMX2</accession>
    <name>A0A835GMX2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMX2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="93" mass="10450" checksum="451F1F955B3F4EAE" modified="2021-09-29" version="1">MKTSSLYFTMEDGFVKAESTNLPMVNTLMVAQYFASNPDLSICSAELRNVKTAMSGRESYGDDALGYVQLKRVQNTCELIRIRLTEPIILYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMZ7</accession>
    <name>A0A835GMZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="213"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="530" mass="61164" checksum="36315A527832A805" modified="2021-09-29" version="1">MAMATSFICQYRDKMSARRGHSILRKHKIQDRTQRILALVPVEHAPSDTSDKSDTNSDNELPPPSPSLVSSSAPSIDSSLECLNINSSPEPETTQTEGELLEPSDIFHAEALQLTPVLQEICPDTPSREPNYDSVPSLSSMISLPSEIGSPMPGPSSTRIKKTRARKQIAPAAKKTKKIPKFTLTYKWKKGIFRHRAIIEEIHEASVDFPDDDPLNYFYLFFSEDIFTDLVEQTNLYSVQQTGKSIQVSEDEMRDFISMHIMMGIVEMPCYLDYWSNKFRYGQIADVMPLKRYQQIRRFLHFNDNNLQDLDRYYKVRPVVEKIRRNCLKQENENKFSVDEMMIPYKGRKAGNRKQYMKDKPNRWGFKNYVRAGVSGMIYDFILYAGEDTFRSYTFTEQESSLGFGAQIVIALARTIKKKPATVFCDNFFSSPELFYILKENYGVFGLTKKNRLKPLEKSQQCKILNPRSARPTSPIRFDNIGHYPSIKEDMGRCKYCQKNTTVYCLKCNMRLCFVTGKSPRNCFLDFHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN26</accession>
    <name>A0A835GN26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cilia- and flagella-associated protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1331"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2004"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2038"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1272"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1483"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1637"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2085" mass="239018" checksum="BB254EE927FFAA47" modified="2021-09-29" version="1">MVVCYSSGSMITFLDVHTKQTWFRRSTTGGTVGSITSYRKDPNYRLVIAEDREGDQDPIIILYTWPQMEMDAVLRDGTANGYACLDFSPDGELLASVGKEPDFNLTIWNWKRHKILLRTSAFTYGVHAVMFSPYCEGQLTTSGAAHIKFWKMAETFTGLKLKGELGRFGKTEICDVLGVYPMPDEKVLSGCEWGNILVWEAGLVKLEVTQRGRKMCHQAPIIQFMLSEAGDEVTTIARDGCVRAWYWDTVDQADPPEDDPFVELNPVAETCVPGCQIMSLKHKKDLLWYAQDGNGGIWVVELDIDKIECDHRRVTTCHAGGIVAMAALRTHPILITAGEDGALHAYHTEKHVLLARYVFPNPITALLYPPLDVDETSRILILGFQDGIMRTLLLYPDRIQGQKDMIDIRVHSALTIHSDDSDTADVIDLISLLKPHSKAISQITINIQRTLLVTCGEDSTIFIYLLNRGSPFTLERIGFVETPNNIAFMTWKPDSDRVLLLCGQVGLIMEAVLPEPIVRTYTDIKTFKLEFESYKETLVKKHFMRHQPFPEEEDLASIDEEALKAKEEAELRDDEDEGEWIGEIELMESESMLGTTITWAEYCEEGVWIVQQGTGALLLIQPGSNKILKYAPFPGAWCEDITALRFVCDGRYLLVGTNTGYIRMVRMPTEEEDNPQHHLNLWLLAQQKLLRKLKGRRLAKEQLQPIPRIDFIDHYYLPMHDRYTGAITGLEFNNDSSALYTAGRDGNIFSFVINFPEQLLPTPELPTPLETLKVEKAKEHSTLEGELMSHEQLKQKEEFDKMMAIANAHKRRVRDQLALLTTEYNKLIKANKALPVSQQIDVTLDTRPLQVQEKELEDAKALTKRKLAHQLEASDLALAKMHSRNIIQLDVFPFAVRAIGNPNIIIRPLRQKNLSAAFYAQLEEVYQQMADAAQKGRRTESAVRRVGTRKASYGPPRVASFLLGLPSKPPYPLKKALKNYHARLNRHHLQYIEWQEHLNRKPDPNAMPPGAAEALKEAEATIGNRILKTEPEYVASPGHNTQMRVCLCRKEVYDLKHEFNEKVLELRSRKVQMVQRMKEIGDRLSEIRIEIPPKLVKPPPPLPQFDDELEFPERHLEVKPEPINPTSRLPQKKGQQGPERRRASVNVTARIRQPRVNRFVPVTDIKPLYASWELLRQRPDHESSPIENEIRERRIERHLYEQDMLLLDADRQVRLFDTRLKELQRERVRVQEKNQLLELHLYQLHREMNVLNKFEMHEDRLAERVYVKLMQVRAVQEQIIDCERRIEEHIAEKDNLDAICQDLQRKFKRLVQDNKFADFLRRIFKKKYRPPRIRDEDDSSESESSSSSSEEEDEGSLDSRDIGPIRLDPNVCPEGCDRETYDKTFEMRNNRHKHEQNMMEQDRLVELLKRDIEAHNKIKRKLSVQLERRKNELREFMLEKQSCMNEVATVVVLRYDQIRAAAIRGCTGPQGLSQAVVFPEALLSRLRKRVLELLEEIKEQKLRQKINRTHLFRMNVDLRAMEAEATELRAQMRDVLTRKLGRPRKVDRTLDDLLRQLARRHKYAVSYATLPHVVTQLRTWSERHSSLEKKYLAALNHYSDRLRVAAALQAQVLPQKPTKDPVEMPGGYNPEVYKRDVMRLLIVRQRQNEQIKQLQEEIASLRQKPLSYRAPHATFTPTEPEQSDIYLFMVPRSLKQHRRKYFPITPLGSTTKFSSEVNVTTLLYDCLDAMRISRDDAELLLSDVINLLPNVVTGKCSRYELVDTTVRKWLLKAGGDPTQYKTQTRAFDALAALADRLVRQQIEVMEAPDDAEGIIGDLEDALRDMTDESNSLADRLGPAIATLLHSAHFTTMEDPETLASLVKSVTDENHPITKDSVERICSYDVLQDIKECGVDLPTEELQKVVECAMDAIRAQIVEPSEISEVQKEVHRVLKEKDIEAMIKKSIVNTYSDRKTLDSETSYIRKCKSVGDTDPKSILTTAPTSDHKGLQTRVSIATPNILGKSMTLSEHDKHEPSSYPKKLSTMSLDERKSLATRVSASILGQDKSSQSIGGVKEKPSVQIDIPAEQHEQTEGEQTEEEPTKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN43</accession>
    <name>A0A835GN43_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN43"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9419336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="448" mass="48315" checksum="284229ACC0B15519" modified="2021-09-29" version="1">MFRRNATTIRVVFKGRKYISGSPLNTTHIIYRRYHPPTQLQYLAWKNTRSPITMQLSRRLHTSPVLSGEEIVSAPTFPDSVSSGDVKFNKKEGDAVAMDEVIMEIETDKTALPVMCPGHGVLTKFFVKQGQAVKSGQKLFSVNVTGVAPAKAAAPAAAPAAPAPAAAAPAAAARPAAAAPRATAPPAVVKSKAAKAKPPALGALRIADPTKAISGTRTEHPVPMNKMRKRIAERLKNAQNTTAMLTTFNECDMSKLMAFRKEHLKTFTQKYGVKLSFMSPFIKAAANALMDQPVVNAVIVDEDIVYRDYVDISVAVATPRGLVVPILRNVDSMDYPKIELAVNELAKKARDGQLSPADMQGGTFTLSNGGVFGSLLSMPIINLPQSAILGMHAIIQRPVAVSGKIEIRPMMYLALTYDHRLIDGREAVLFLRKIKSGVEDPTSILAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP18</accession>
    <name>A0A835GP18_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12571">
        <property type="entry name" value="RRM6_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000738">
        <property type="entry name" value="RNA-binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034421">
        <property type="entry name" value="RBM19_RRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="483"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="618"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="722"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="849" mass="96189" checksum="4146FA30D82E5AF0" modified="2021-09-29" version="1">MSRLIVKNLPNKVTVEKLKDIFGEKGEVTDVQLKYTKDGKFRNFGFIGYRTEEQANQAREYFDGTCINSMQIQVQTCANLGDEKKPKAWSKYAPDSSAYKKLHKDEIEDKKKAEKKEKKVEKNKNKIKELLKKHKDDPLFAEFIEAHKETQEHDNPKEDNKSKKEKKEETQDDKPEPKKVADTAISDLEYMKLLMKKVGGPGKENVTEETNEQTTEEQQPKKIRNRPLFHVKIMGLPYKCKKKDIKEFFRPLVPFSIRLPYGKGKKVTGFCYVGFRTEKELKKALGKDKLFLESIGESGSIFVRNLPYVVSEEELTSLFEKYGPLAEVNMPIDPILRQPKGFATVTFVMPEHAVKAYTELDGTAFCGRMLHLLPAKSEKLEDDEDDEGLSFKEKKAKKLKAQAKSSHNWNVLFLGTNAVADVIASTYNTTKEQLLNDNNKNTSAAVRLALGETQLVAETRAFLEGNGVYLEAFNKPAKKRSKTCILVKNLPANTEKEEIKSLFVKHGQIARFLMPQHGITALVDFIEPFEAKKAFTKLAYSQFKSAPLYLEWAPENVFIKSAEKIDSVKNTNATQSDDVKDEVETSSSTAPVPKEPVSNNQKVQEKDETELEEPENDTTLFVKNLNFKTNEDSLKAHFSTVGKVHSVSIAKKKDPKNPGQFLSMGYGFVQYYKKEHANEALKNLQVTTLDGKSLELKRSERGNTNEVRTSKKSNKDTAQNGTKILVRNVPFQANRNELHEIFRAFGEIKTLRLPKKLTSGSDQHRGFAFVDYYTKADAKSAFDALCQSTHLYGRRLVLEWAEQGDETEDVALLRKRTAQSFNAQAPGGKKSRKGAVDVEKFVEGDDSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP26</accession>
    <name>A0A835GP26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heat shock protein 83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP26"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000003">
        <property type="entry name" value="endoplasmin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032958971" description="Heat shock protein 83" evidence="10">
        <location>
            <begin position="21"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="726"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="734"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9420396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="86937" checksum="B73E4D7D96BB10C2" modified="2021-09-29" version="1">MKYFVLVGVGILLLAGWSHAQEGVGVGSVEEVTVDADLGASREGSRTDAEAVLREEEAISPDELSVAQMREIKERAQNYTFQTEVNRMMKLIINSLYRNKEIFLRELISNGSDALDKIRLLSLTERDVLDANSDLSIRIKAEPEKRLLHIIDSGIGMTRNELINNLGTIAKSGTAEFLSKMQDAEKSGAQEMNDMIGQFGVGFYSAFLVADKVTVVSKSNSDKQHVWESDASAFSVAEDPRGDTLRRGTHITLHVKEEAADYLQPDTIRNLVKKYSQFINFPIYLWASRTETVEDATEEKRETKKTEKTVWDWELMNDNKPIWTRKPNEVNEEEYTQFYKSLTKDTSPQLAKAHFVAEGEVTFRALLFVPRVQPADSFNRYGTKTDHIKLYVRRVFITDEFNDLMPNYLAFIQGIVDSDDLPLNVSRETLQQHKLIKIIKKKLVRKVLDMLKKIPDSEYESFWKEYSTNIKLGVIEDPSNRSRLAKLLRFHSSRGDGMTFLADYVARMKPNQNHIYYIAGSSRAEVEKSPFAERLVRRGYEVLYLTEAVDEYCLSSLPEYDGKKFQNIAKEIFDLEESEQQKERLEAYKKQFEPLTTWLGDKLGAWVTRCVVSRRLARSPAALAATAFGWTGNMERLALSNAHQKADDAQRRHHLTQKKMLEINPRHPLIAELLRRVQEAPDAPETARAAETLYRTAALRSGYMLQEGQAVDFAVAVEDMLQQSLGVPPGALADLDEDEPEDSPDAEEPTPDEADEVAAEDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP86</accession>
    <name>A0A835GP86_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="89" mass="9893" checksum="CE56FF4557C63481" modified="2021-09-29" version="1">MDDVGQDGAFRRQDDSPARPGVLIPETRLLGSRTKIARCRRKVLKGDKIVIWLITKFLQTGYGVLCVTSEQPSLTLKNDLTSEHVIGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPW9</accession>
    <name>A0A835GPW9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_018452</name>
        <name evidence="7" type="ORF">HW555_001504</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000818">
        <property type="protein sequence ID" value="KAH9630536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14722">
        <property type="entry name" value="bZIP_ATF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9630536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="407" mass="44559" checksum="CC5F564C8DE648D0" modified="2021-09-29" version="1">MNSTSMSSTVPTIKCEDTSPSPSAPVGTDGDTASTYNLSVNVNLSAAMINMLTAETAGPTTLRTPEIVNDVITMTNPLDQYNYEKNASFKSGSGNDSNSSMSNGSSATSPASSTPPSIQKTCSELIKAGLKLSIESKRKMSGSDTDVGMKRMKKEESDDDYDSSHTLTNKSDGLTPEDEERRRRRRERNKIAATKCRMKKRERTVNLVTESEVLENQNIDLKAQLKDLEVQKRRLMDMLTIHAASCVKSNNSNTRQSPTTPYNMIGPYDSPTTFPVSFDAHSPYIRPESANILTSSYTCVTPLNGDSSIDTISSLDTIYVAPQLTDPEYNRPDSVLSLPPASERSYVTTDGYLPKSTNLLVPIDSEQDYYDPEANYNLGNQQCHTYPNTIPEATSKLNNGLNDGCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ24</accession>
    <name>A0A835GQ24_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ24"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="28317" checksum="B440E90EA9DBCF67" modified="2021-09-29" version="1">MTWDITLDFEYVVTKKPPPRICFGSAQERVALPLKGPCLSPFMRRMAIETREDVGPTTYEIKRDAFSDVTNRPPPRAPRPKAPIKQNCAPFNSTSKRKGIFSPSYNPAPCDYCPEYIKRQMKFAYSFSGKKTLKCAVQIKCVPYNLDECGYCGCSCSQQGDYWQYENRIFLCRKHYNRLFKHCLSKFQGAKLAEFKSVRDCFFAHAHNSCKAALKIMKSEEIVKKLRKEAYLDLFFPQRRFCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ29</accession>
    <name>A0A835GQ29_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ29"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000290">
        <property type="entry name" value="Unc-93 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60677" checksum="FCB532C02238BC37" modified="2021-09-29" version="1">MYCTIITGQQEIHGMTATHGGGREDDRPDKDSVYTIKTGFKNDGYQHDRDSNDDIVKPPPLPAEDDNYMSGKVKLSVNEKWRILKNIAAVSAAFMIQFTAFQGTANLQSSINAADGLGTVSLSSIYAALVVSCIFVPTFLIKRLTVKWTLCISMMCYAPYIGAQFYPAFYTLVPAGVVVGLGAAPMWTSKATYLTQAGSVYAKLTDQAVDGIIVRFFGFFFLAWQTAELWGNLISSLVFSSGVHSTNSTTDNSSKTVLTCGANFCMIGGGHHDNQNLHRPPDSEIYEISAIYLACVVVAVLMVALLVDPLSRYGEKQRKSDPSKELTGIQLLSATAYQLKKPNQQLLIPITLWIGMEQAFIGADYTQAYVSCALGIRSIGYVMICFGVVNAICSLVFGSAMKYIGRFPILVMGAALHLGLIVWLLIWKPSPESPTTFFIISGLWGVGDAVWQTQINGLYGVLFRRNKEAAFSNYRLWESAGFVIAYAYSTHLCARMKLYVMMVMLLIGVAGYIARRLKAIAEDPAIAAEAAKQPPEEDDEKDEIDDEIIITHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR56</accession>
    <name>A0A835GR56_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR56"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="615" mass="68940" checksum="75EC679C0B3D6D45" modified="2021-09-29" version="1">MWCNNSSCLAPTTGASPQIFAATLQYLAAAQCLLNHENVPDTPIINFQSFDFIIIGAGTAGSVLAKRLSEVKDWKILLIEAGGDPPVESYVPGLDHSITGSFNWDYVSLNNGVTDQAIINGSVYLSRGKMFGGSSNLNEMHYIRGHDQDYQKWFDAGDIDWTHDDIHRCFKKIENLQNMKMLRDPAIRKYYGDKGQLVINRFNSTNKDITHSILKSWNEMGFKFVPDLNMAGLMGSGITTVTAANGERQSTYTAYLEPIKNKWNIKILKNAVAKKLLITKDSKLCFGVEVEKDGKILNFYATHEVILTAGAVSTPHLLMLSGIGPKEHLLSNDITCLVDSPMVGQNLQDHLLVPITVYGNGPEKPTTKETYRDVINYLLDRSGRLAESTKFTDVTAFYSTKNQPYHPEFQLYLSIVPKNTSNLEELLKSQYRYKDPIVDSMTELNKKHALYFFAFTLLHPYSRGNISLSPNNPEDAPIIYTNYFSDARDLRTAVQGLKLASKVVKTTFFKSIEGFLGRMNWPACDHFELDSEDYWKCVSLNMVTSMSHLVGTCRMGPNPNTAVVNSRLKVHGVSHLRVVDASVMPEITSGNIYAPSIMIAERGAEFIIKEYHNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR78</accession>
    <name>A0A835GR78_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="208" mass="25086" checksum="C3C09C52ED7F5C96" modified="2021-09-29" version="1">MASYYRSPLSIFFSVDFVDEWFLMKSPVPVITITATYLYFVLKVGPDYMKTRKPYNLNSIIIIYNIFQVFVSVYLFYLCMQLMLANGLVSKTCLLEHEDTRRDITNVMYYYFLAKVSELLDTVFFVLRKKTSQVTFLHVYHHAMMAIVSWSILKYEPTYMTIYIRNVNSFVHMIMYTYYCLSALPVLKKYLWWKKYITKLQLVRFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRB6</accession>
    <name>A0A835GRB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_004922</name>
        <name evidence="7" type="ORF">HW555_002237</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000190">
        <property type="protein sequence ID" value="KAH9642390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRB6"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9642390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="14349" checksum="149D71B4393923E6" modified="2021-09-29" version="1">MSSVEHVSRVRRLYKLIFRVHRALPPELRIMGDNYARDEFKRHKKCNPEEAKIFLNEWTDYAITLAKQMKPIQQAKKKKVGEYLDPQLLDHMTDEQLVQLYELHKAATEPSTEEQSIPDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRI5</accession>
    <name>A0A835GRI5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="824" mass="91135" checksum="5C930A56F6ED70D3" modified="2021-09-29" version="1">MNDISLKIVESPKSHGGVDVSPTGDTSAENEVDPLAIDEGELDRVKEPVSQEAELEKLDEEKAGNCDDNAKEENLSESQTGSSDSFVNVQPEKPENGNESLKSGRSSSSPPVVAKTLTPEPPKQPQNEPAPTIEPVPSTSKAPDVIEKLVAADNVVVETVVPVKGPVSEKEELMVVEEPKKLEPEVDADMTEVVTVEEKAEQKVEKPKPKSVNGDVVTKEDQGTKRRPSEDVDTESPLKKLCQEVEKTFPQHDTMINDYIQRATKNNVDELQRHTEQLLSEIQTLRELAQKKEHEWNNILHLKKVKEEILLRLLRRKQVLNYEKSQEVNGGDRDRDPFEYLNNQAKNLAIDKSDEISGLSLKQPGTSMAPMLPTPIMPSTSHFNPMAGLPPPYDKAHMSMPKPVFPQQMMMPGHMTGFPRDMNGQLPSSFGLPMGRQGPTKDVKSIIADYRQRNPEVTPRRGRRMKSILNPNIMNAPRPIAPKVDNLNNLNNLNMLFNNLDMNQKAMLERLQQFQASGLPNGLSFKDVLVQFANMQQASAGLIPNRPPETITTRAEHHIRPEGRRRQERSHEDVHVSVKQAERLASPSPRLPPPPPYPEISLLPVTTSQSETTQQNSLLHGILTKQSSPASHSYSPTLAKLLMSPERIQSAPTLPSFGQAKNCGEITITPVQPTPPAEPQPEKPEEVVQLDDEESPASEGEASGSPSGSGSGRLVIDEGVAKPRLRGPRTKRMRMRRRPCARAVGGEMRNLSVQAVLTSGTVVGIVRSQHGMNIRTCALDSRVKYGGSRGSQEFDKQNVVISETKGGLVYNMVPFKSFYTILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRQ0</accession>
    <name>A0A835GRQ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRQ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032351762" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="8190" checksum="3796E5CDA576544A" modified="2021-09-29" version="1">MVRIALVILVVFVISCLAAPGERVRRHGYDFTHGGYGGGYGGGYGHNGHGGHGFGGHIPITQSFSKSSASASSSSGGGTIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT44</accession>
    <name>A0A835GT44_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_000280</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF274">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="70"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="419"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9424979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="643" mass="71094" checksum="4EDEF3A12BCCD362" modified="2021-09-29" version="1">MLPRHRPHNSRSPYTPYKIPSEDEGPLYKITQARIDAELNNTSWRVRPEEVLVEVGTGIGASPALHSINEVLKLSLGWSTRGSTGAASTLGTPSLTLSSFTVGLYKGNRVAVKKIHRKKLDLNKKLLWEIKQARNVSHENTARFIGACVDCPLVFVLTEYCPKGSLKDVLANDELQLDWNFRTSLVHDIVQGMCYLHGGLGAHGKLRSSNCLIDGRFVLKISDYGLNTLCTPTDLIKDDTYYYKLLWTAPELVASSIYPGAAASLKGDVYSFGIILEEIVLRAGPFHNYTNTMSSKEIVSHVCARESPPFRPVVSVGEVGAAAGGGGGAAVELLDLAERCWAEAADDRPSFDTINANYIKGYCDNLMDDLLRRMEQYANNLESLVEEKTEQLSLEKRRPVAQQLMAGEVVQPESFECVTVYFSDIVGFTELCAASTPMQVVDLLNDLYSTFDRIIGFYDVYKVETIGDAYMVVSGLPERNGDLHAREICLMALAIVEAVRGFVVRHRPTHRLEVRIGVHSGPVCAGVVGVKMPHYCLFGDTVNTASRMESTGQPLRIHLSENTRALLDQWGTFVVERRGEVELKGRGRMLTHWLLHCSEPEARPPTQGLQPPPQYPILFPTLPQPALSLQVPYLVVEPPTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT83</accession>
    <name>A0A835GT83_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Stress-associated endoplasmic reticulum protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT83"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="8145" checksum="9089A59A85CA01DF" modified="2021-09-29" version="1">MRQIYLLIIKNGPQTEDAYRQRDCQQKHYHEGMFEKDDQYPVAPWLLALFIFVVCGSAVFQIIQSIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GV14</accession>
    <name>A0A835GV14_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_008922</name>
        <name evidence="2" type="ORF">HW555_000178</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000188">
        <property type="protein sequence ID" value="KAH9642512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GV14"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032306091" evidence="1">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9642512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13783" checksum="527C86D9AA991227" modified="2021-09-29" version="1">MKSILVLCLLVAAVSCRPETYDTRYDNFDVEALVGNVRLLTAYGHCFLGTGPCTPEGSDFKKTIPDALRTGCGKCSPKQRHLIRVVVQGFQNKTPALWQQLVKKEDPNGEYKETFTRFLNAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWQ8</accession>
    <name>A0A835KWQ8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000702">
        <property type="protein sequence ID" value="KAF9405657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="131" mass="14721" checksum="35C2C5E9201217B9" modified="2021-09-29" version="1">MEVESEKECRLCFPPLPAVLVLAGAVPTPNLLGYGPPDVISLEARPRIEGFEFPDGDSVEARLKICPELMSRVNTVLFELRNKFKMKDIGRTSPTERDYIEPKILPGNVQFVKVVEAVPDAQRLSKRQNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYJ5</accession>
    <name>A0A835KYJ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger protein on ecdysone puffs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000552">
        <property type="protein sequence ID" value="KAF9406755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYJ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF9">
        <property type="entry name" value="CIP1-INTERACTING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63252" checksum="BC0C0A1AFAFB89A4" modified="2021-09-29" version="1">MANRRPQSNSGRRMDFQRNDRGKNFGRSGVSPWQGSGPGGGMPNLLPLSGGSTEATLALANNIINLLQPRQNPVPSLLDMPIRRDFGPNVGRYDRGYGPTRMGNQGNFRRTGTYNRFGERVNNNRKPYRPNDGQRQQNKSSPKRRPIQRLNLLRRANHPAVKQKRRMMLLQLNKIRRRIREMKRTRKAGQQPARDFYCAMCDMYAADGAIHRTTVGHRKLKKYLHPTCTSCHKEMPTRIELDEHRLTAEHLRNMQDKQEIITKPKPEVMVISTLNMEQMYLREDRQRRRRNDDKNGTDKDGDDAEAKDGEGENQDEVKNEAEGEAKPEGDAEEKKSKLDNEKTILDYKEGDDLTGATQDMFPAYSTERGVGGSFLSEFRCVQCSLCRKLLDTDETAQVHLRTWRHHQLFTRLLAEKSGTQLGNDTNSNKRPLDADDNSDAKRRKVDDETEQNGHENGEENKEDELLDSAAEDSILNKEDGEGGDGGEDMENWEQTVDEILEDEKNGPAQEEQPAPEPPKQEEPVKQEPEKPKTPPPVAAVAAMRDGYLFRSGAEAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZT7</accession>
    <name>A0A835KZT7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000426">
        <property type="protein sequence ID" value="KAF9407883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="10159" checksum="BDAB900CA93E66FA" modified="2021-09-29" version="1">MIVLNNRPAEQQNPNDAVDRVERRQRVVDSASDVGVAARGGALRRGAARGAGVAGGARAGARALRTLEIWVLFNERSITIHVPSATITDRLAFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZX0</accession>
    <name>A0A835KZX0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000348">
        <property type="protein sequence ID" value="KAF9408984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZX0"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000097">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF31">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="16794" checksum="E06A7E5037D0FE48" modified="2021-09-29" version="1">MGDGFRKVYTDGACSSNGRSGAQAGYGVYWGDDHPLNVSAPVSGRATNNSGEIQAATRAMQQAHENGIEKLEIVTDSKFLIDSATKWMPAWKQNDWRRASGEPVKNESDFRELDRAQRNLEVKWQHVPSHQGVHGNEMADRLAKAGARKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0F3</accession>
    <name>A0A835L0F3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000504">
        <property type="protein sequence ID" value="KAF9407113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0F3"/>
    <dbReference type="OrthoDB" id="6419576at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032816044" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="250" mass="28500" checksum="1231FC42A6C11389" modified="2021-09-29" version="1">MDKKYTALVLAFLVAAADANSINLKSQPTSKLLEASRNWGDLGQSATVNDYVDNTIDMIIPLIVKHGLDPMDLPEVIEGFEVRPLLITYSAWLKIYDGYMTGLVNVSRSGDQEVHYFAKMLRLRIKLQFRDLEFIYKYLIKAMNIGPTGGIIASLNRFVVIVDILLDFNNDEIQLQQFRLTDIGRLRVRFTGNILTDWLLNPVLNLFLRIFDTIIIKVVEVNIRNAVQNEIDSINASVKEVVRELEAMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1F8</accession>
    <name>A0A835L1F8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000362">
        <property type="protein sequence ID" value="KAF9408765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="84656" checksum="F50E30F27931E420" modified="2021-09-29" version="1">MSSSEIYENQLELYESIKKVGINVKKDGWDRKNSDYFKRRMQLLENLWNDFQFNHDRLSTEEAMSHPYFTSELHSKTLHCYKTVKELILQQNQQLTAQVRLPTKADSIQQDGGSTCSSKQEQDQKEKREDNNIAPDATQGINSEQSTTHKPIVTKTESGTNSKLDEMLRKQSANFKAFMRAHANIQVEFLSEKWEFQDALQTIQARWSAIDTLHWELECELNGEKIGVYEERYNRFENQYNELKKALNTKMWSGAHREKTTPKLEIPVFHEAQIKKIHDVTIECLNAIKNLGVDIDTWDPILVHILSQKLDSETYSDYIDSLKNSRELPSLKEFLEYLEAKFTALEASRRKQDNIPKPTSSSGQRSESPFNKKHFSKHYNNNYKSNNNKNVAKSFHASSTFTCPLCEEKHGLYNCAKFLEMSNNNKISTVKKLQLCINCLFSHNGKKCTSDYRCRKCTAQHNTLLHEACTKTATRDSTNSSNVSQNDETSEILLATAIIKIDASDGTQHNMRALIDQGSQISLITEHAAQLLGMKRQRCKGVIFGVGQKGNNCKGMITITCTSLYNNFKFETSALIMNNLIKNLPNKTFAKPDWSHIHNIHLADPEFYVSRPVDLLLGADIYSWIMLGGMIKGADTTQPIAQQTQLEAEYNLLKRSEATVEKQFKLFNQHLINVDKFTNNLQNEINSQELSIEFALSAISANSLLEHLRNTQEILMDTATNIYSGKMNLHLIAPEQLQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1G2</accession>
    <name>A0A835L1G2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008739</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 14"/>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1G2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="363" mass="40859" checksum="0D37B7453AF21D18" modified="2021-09-29" version="1">MEDKNVEFIPKNFPELKNDRLLRAALGKEVDKVPVWVMRQAGRYLPEFQEVRAKHDFFTVCRTPELACEVTLQPLRRYPHLDASIIFSDILVIPQALGMTVEMHPGVGPVFPSPLQDPSEIDNLKEEGAVDRLLYVGKAITLTRHKIEGKVPLIGFTGAPFTLMGYMIEGGGSKTMSKTKEWLEKYPKDVHKLLSLLTRVIIDYLIMQVESGAQLLQVFESSADHLNRDQFIEFSAPYLKDIRSGVKNKIEAKNLEQVPMTVFAKGGGPYLDIQTGLGYDTIGLDWTVDPEEARKIVGDNFTLQGNLDPQDLYKTPEEITKMTIEMVQKFGKKRYIANLGHGITPQTPLESMKAFTVAVHEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Y6</accession>
    <name>A0A835L1Y6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_007683</name>
        <name evidence="11" type="ORF">HW555_013982</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000801">
        <property type="protein sequence ID" value="KAF9405152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000134">
        <property type="protein sequence ID" value="KAF9414429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Y6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9405152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9414429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="47870" checksum="C6BE09A6FCF3CC46" modified="2021-09-29" version="1" fragment="single">NIAIASTGYSMGWTSPVNLKLQANDTTNPVGNPITKEEEAWIGSLLTVGAIFGPFLGGFAASKIGRKWGLLSTAIPLFVGWILIAATNNVGMIYGGRIFWGLAVGMLFTISPMYCAEIATDDSRGALGSFLQAFITLGYLLIYGIGPYVSYMVIAYVGIIFTAVFVAGFFFMPESPFYYLAKGDREAAASCLAKIRGRSHEGVQAELDLMAADVNASLEKTATVADVFRGSNFKAFYISCALVFFQQFSGINAVLFYMTNIFEAANSSLDSAIATIIIGVVQVIASCITPLVVDRLGRRILLLISASGTAIGLGLLGMFFILSEKGSPVVNSIGFLPILSLVLFIVTYCWGLGPLPWAVMSELFPIEVKAIASPIATAFCWVLSFLITRYFSAIASGLGMGGTFFIFGACCVAAFFFTLFLVPETKGKSFQEIQDILSGKPSKLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Z9</accession>
    <name>A0A835L1Z9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Z9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="139" mass="15598" checksum="559DF2CD4D8A1E01" modified="2021-09-29" version="1">MTFTLRLGCTTEEVIVKRTAKKGASKERQEMRRTGGGPPPAQPSGFCSDATDWLREIIPSSIDGNMAIFDDDVIYQKPTVFPRSENIIIEVVEDMTEEAHLQNKIPDNGKTNEATNNEKWDFDPSTPPTALSRDQCHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L203</accession>
    <name>A0A835L203_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Asparagine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_013937</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000775">
        <property type="protein sequence ID" value="KAF9405247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L203"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000151">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="253"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9405247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="555" mass="63222" checksum="F21968FF7188B8B0" modified="2021-09-29" version="1">MEDLSIGEIYTSDKKGSDETGDGTEAKPFKTILQAMRHAGKEPFPTIYVDAKDDTKVYEVAAKSQLKKIHKIWVRESYKAADKAKAEEETNDKRQQNLEEAKKIVIKEDPSLPKATYVKIAEAAEHRGERICVKGWVHRLRRQGRALAFLTLRDGTGYLQCVLHGLLCQTYNALVLSTESSIVIYGKLEVVPEGKMAPGGHELTADYWELVGLAPPGGADAILNEEAYLTSSLTTVGDLEHIMIRGENTSKVLRARAAVTRAFREHFQSRRYTEVTPPTLVQTQCEGGSTLFKFSYFGQEAYLTQSSQLYLETCLATLGDVYCIAQSYRAEQSRTRRHLAEYSHVEAECPFITFEDLLSRLEDLVVDVVDRVLASPDGHLVSELNPNFKRPKKPFKRMAYTEAIEYLREHNITKEDGSFYEFGEDIPEMPERKMTDQIGEPILLCKFPAEIKSFYMQRCSDDRRLTESVDVLMPGVGEIVGGSMRTWDHEELMEGYKREGIDPSPYYWYTDQRKFGSVPHGGYGLGLERFLCWLLDRHHIREVCLYPRFLDRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2A2</accession>
    <name>A0A835L2A2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000695">
        <property type="protein sequence ID" value="KAF9405702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2A2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="38"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="228"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9405702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="570" mass="64106" checksum="ACC265F98F7E63C0" modified="2021-09-29" version="1">MGDEKKVMFHEMELDDRILKAISQLAWPEPTLIQETAIPLLLEGKDVLMRARTGSGKTAAFTIPVIQKILNLKNTSTHQCIRALILSPSKELCGQITSVIGDLTTKCAREVKCIDISSSGDTATQKALLSDKPDIVVATPSRALAHLKANNMRLKEDLAVLVVDEADLVFSFGYEDEIKELLGHLPKIYQAVLASATLSEDVLSLKKIVLRNPVTLKLEEPELAPSTQLQHYHLFAEEDDKAAILLKLYLEQFKIGSCVLNSELPAAVRCLSVDQFNRGRYQIIIASDEMALEKPDGGILPIEERKKKKQNSKRKKDKESGVSRGIDFQHVSNVINFDFPLDVNSYVHRAGRTARGKNQGSVLSFVSIREKPLMDAVEAHLSKGFKSHQVIQKYEFALEEVEGFRYRSRDAWRAVTRIAVREARLKEIKQELLNCKKLQGYFEENPTDLAALRRDKALHTVKVQQHLAHVPEYLLPAALRSDETVDDEQEGAAAPAPAPQKKKKQNTQYGSAKRHKYQARKNDPLKKLGRETEDNSRRRHVADTFVSKSPRGNQHDTALAVVSYDHYQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L322</accession>
    <name>A0A835L322_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L322"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="67" mass="7364" checksum="6FC041554F787594" modified="2021-09-29" version="1">MQTTLVMAKFASVHNAYAYGVSYDYTTFSEPASHGRAQPPSSCDYYRPSSPRSPSPGTRYHASPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L367</accession>
    <name>A0A835L367_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cecropin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000226">
        <property type="protein sequence ID" value="KAF9411390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L367"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000875">
        <property type="entry name" value="CecC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00272">
        <property type="entry name" value="Cecropin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00268">
        <property type="entry name" value="CECROPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032835563" evidence="7">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="62" mass="6630" checksum="0CF13DA4583D0D12" modified="2021-09-29" version="1">MKFSRVFLFVFACLVALSAVSAAPEPKWKVFKKIEKVGRNVRDGIIKAGPAIGVLGQAKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3F6</accession>
    <name>A0A835L3F6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000134">
        <property type="protein sequence ID" value="KAF9414423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3F6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF66">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38006" checksum="5E9C1F0337F5E19A" modified="2021-09-29" version="1">MMIVAEAWKASYLYWVFPVLIVATVFAILGLFGVIFAIRLFAKYTCGRFRKTTRMDGKTVIVTGCTGGIGKETARDLAKRGARVIMACRNMEAAEKVKAEIIDSTKNTQVVVKKLDLSSFASIREFAADINKTEPKLDVLVHNAGYADTFKKRKTVDDIEMTMETNHYGPFLLTHLLIDLLKKSAPSRIVVVASSLYRLASFNIDNPNPVDTIPGYLYYASKEANILFTRELARRLEGTGVTVNCLHPGLIETGIWSSVPPPLNWMLFPIIKFFFKTPKQGCQTTVMLAVDEELEKVSGKYFSDCKESSLSSSVSNMSRAKKVWEVSERMVKLGDTDPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3M7</accession>
    <name>A0A835L3M7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000202">
        <property type="protein sequence ID" value="KAF9412080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3M7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="229" mass="25125" checksum="54098C52AF501D1B" modified="2021-09-29" version="1">MCVYMGNFYDGSLNNYTLMLSVLEVTLDNSPVKHTIDPKRRNEIVEETFSEQKGILLNMLESKLKEVRDKKKKSNDNNGGHNTNCNGPLQNIDVKLKVNGISAIGGANVNLKYGTGKGSVSFDADGISNIGKIQMSLALGETFHIPGLNNLFIDLRQKNCTIHNVNEPQEDIENNNTRRSENEATHRESASTITANVEGNLSSTAKAVKVKKKTVHPVNSNSTAKPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3S4</accession>
    <name>A0A835L3S4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000428">
        <property type="protein sequence ID" value="KAF9407864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3S4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF69">
        <property type="entry name" value="NOSE RESISTANT TO FLUOXETINE PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="696" mass="78436" checksum="48B9775F8BBBEBEB" modified="2021-09-29" version="1">MSIVFDASGQYTPNVLFGNEYWLGSLNACKDLQLTQYYAQTPPFPTTFYVAKINLTIDNDHLPQSRLMLVGECVPASCDISALTMILSAAEQAAAAQASDSGLAASFSTVKVRPVPGDYDLFADPKLQILGSVMTIVLILMLFASLYEGYLERKYRLAKETRDLEVANDDNANHKQPANNNVVADGKPMPTDNGDRDLRRETCGLWSEVLLSFSILSNGRTILSTDPPNDGALTCLHGMRFMSVIWVIMVHTYLTIFYVADNKTMRVITERNFWYQSVGNASYCVDTFFVISGILVTILFLRTEDKKSAKADQQDKQDINKNLNGFSNSALSISVISQQSFKEDLLDKPKTRAYSMAEFVTMIKSFFILLSYRIVRLTPAYGFVIGLNEIALRYTHDRSVFEPAIFDHITCDKYWWRNLLYINNLYPQREMCMVWSWYMANDTQFYVVGIILLLISVKHPKSAMVSLGLLMVSSWATTIYISVWYQYKARIQEPFEMFDPLYDKPWSRIGPYLVGKKFNYSSLLVTSMIVGWYLHKTKCQLKLPYWVVAVGWPVALGIIGSLIFSMVDGYFEVWPTAFYISVGHTAWGVAIAWVAISCCSGYGGLVNSFLSYRGLLPLSRLTYCAYLVHPTIMMYTSFLLDGPYHMQNSTVLAIYAGYAVMAFLASFAISLAFEAPAVRLLKIISGAPRSKKSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4J0</accession>
    <name>A0A835L4J0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_016745</name>
        <name evidence="8" type="ORF">HW555_006440</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000096">
        <property type="protein sequence ID" value="KAF9416117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000126">
        <property type="protein sequence ID" value="KAH9643538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF680">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="74"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9643538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="508" mass="56088" checksum="705A37C0EC953E2F" modified="2021-09-29" version="1">MLSFQEPEEWSRRQSGPMINPSFEPDDFLPQSLSPVKDEKKRPGDKSIFLVNMKEKNIPEVEEYEPYDNRVVDHPTTNLETFLHLMKGSLGTGILAMPKAFSNAGYVVGSVGTVVIGVLCTYCIHILIDSCYVLCKRRKVPSLSYTAAAEAALLEGPDWCKACAPYAAHVVNAFLLVYQIGTCCVYVVFVSENIYFVLTKHFGIEITVLQVMLCILLPLVLINWVRDLKYLAPFSAIANAVTIVSFGIILYYIFRETPTLEGKVPAGKLANFPLFFGTVLFALEAIGVILPLENEMKTPRDFVGKFGVLNCSMISIIVLYVGMGLFGYLQYGDESEGSITLNLPSGQEVLANVVQCLLAFAIFITHGLACYVAIDILWNEYIGIRLLNSKHRFLWEYFIRTTIVLMTFGIAAAVPALELFISLFGALCLSALGLAFPALIQSCTYWYYVSRSERIRMIVKNAIVVLFGALGLVVGTWTSLERIIATFGTGGIEAGSNHTLASNTTQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L512</accession>
    <name>A0A835L512_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L512"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="462" mass="52836" checksum="5CB76906A181405A" modified="2021-09-29" version="1" fragment="single">MPVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQRTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKLHRYNNEQALFTHQIEIFLNQPNIQKQSSSEIKRLYDTTTECIHAIHNLGVNTNAWDPLLVHLLCKKLDTDTQTDYREARVEPRKLPKLDELMTFLEGKFTALEQITKYDKEPATSIKRTPNPKVQNNYYKYNNYKGFNHRNYQAQAIHISKCAVCNLNHNRNLFSCKKFINMTPDLQMRIVTQSNICKNCLFSHDGNECTSTKRCKSCQGNHHTILHEALDDEELLLTTLSINVRCSDGTYITLRALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQSKGLVSIDCQSIYGDYNFTTEALVLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5L6</accession>
    <name>A0A835L5L6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_002207</name>
        <name evidence="7" type="ORF">HW555_004357</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000637">
        <property type="protein sequence ID" value="KAH9633756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5L6"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9633756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="15349" checksum="8B7BB5C9FE428DC2" modified="2021-09-29" version="1">MANSGKGTFQPDSDVHISFEDQQKINKFARLNAKVDDFKEELKVKQNDMKNLEEAVEELSLADDADKIPYLIGEVFICQGLEDTLKSLEDAKTRKVNEINELEAKCDELKSQMAELKAHLYGKFGSHINLENEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7U4</accession>
    <name>A0A835L7U4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="7">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7U4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="259" mass="28665" checksum="A0CE150E2A3AC199" modified="2021-09-29" version="1">MTLLVRNILNLRSSPSSIICRKQIYTTPRLASDMLLVHRDTRENNAKIPFQFTEANMKRIQAIVQNYPEGSQVSAISMAMDIVQRQIGWIPISAMHKVAELLSMPRMRVYEWATFYTMCKRTYRGKFNVKVCKTLPCMLRGSDIIIQAVVDATGCPVGGLSEDRMFGVDLVECQGACANAPVVVIDDDYYEDLTVCDVYNIIQTLKCGNIPPCGPQSGRFAAEPGCGLTSLLTCPPPPGYCIQEALLQNTPGGDDCNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L857</accession>
    <name>A0A835L857_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_006999</name>
        <name evidence="2" type="ORF">HW555_003781</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000448">
        <property type="protein sequence ID" value="KAH9637355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L857"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF120">
        <property type="entry name" value="CELLULAR RETINALDEHYDE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="114"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9637355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="38276" checksum="B486BC2154C5DE4F" modified="2021-09-29" version="1">MTTASMLLTVATTWNVSTDKIDKEGCLSLATKHVTAEAAKEVRESPSTKEQALTIMREWIQQNIDIKNVRQDESFLLRFLRHKKYSIPMAQQTLLKYLSLRRYYPEIFKNIDCDDPKLKDILSNGYIVVSPVRDSKGRRVIVYNMSKFNAHKYNCWDMCRAHLLVYESLLEDSMDQICGYVHVGDGSGVTGAHITTWNPTDFARLLKWGEQSVPMRHKEFHCVNVPTALKYIVDFAISKVTPKMAERLNIHTNLKQLHQHINVECLPTGYGGPLKIEDMVKYTSQLINDQKKKVLGLDTMEIISTRGIISSRRPNTIVVNGDVAVQGSFRKLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8C3</accession>
    <name>A0A835L8C3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SREBP regulating gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SPRING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019352">
        <property type="entry name" value="SPRING1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481:SF0">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10218">
        <property type="entry name" value="SPRING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="23136" checksum="7305FE15D2405A7E" modified="2021-09-29" version="1">MWYAAVVRFIRRRLVLGIIFASSLTYCIVSFLREGNSRGMIYQDVSFERKPFVWRTLQEHNDTIDHIMCRNSVQGKSLLVDDRGYVCHRSDMTKNGCCDTDADSADRYSCETCTENNCCIIYEYCVSCCLDPSKRDMLEVVLSKLSTEKNVLFRSLSDDYELCLTKCRTSSHSVLHENSYKDPINKHCFGDELPRSRTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8P6</accession>
    <name>A0A835L8P6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="379"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="565"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1674"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1858"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="2039"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2250"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2298"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2250"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2310"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2330"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2362"/>
            <end position="2378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2378" mass="266004" checksum="8D9C18CAC4BC836E" modified="2021-09-29" version="1">MAGPSENQRSFRLFVTHVDGDAHFLKISGQVDQQASLMIESLFDAARDNLEKGIGAVPPAAIHEGVICAAKYKDGIYYRAKVVSTNNLSTGLVGVHFIDYGNKDIISLSAIRFFDNYDPLFLKIRGQASDYYLSGVMQPSGRWEEPLLLKLQSLVCYSEYVATVDAQTRTIPIISIQFKGTDLSSHLVSIRFGVALPLAKQEVLLLQLSGDNQQASNWQPSFPNEASNFPEHVPFLMNQNFPANPASTMRIQQNASLPFNGSIQMAPSLIGQRLLVNKASRNPGNLKAPGRQPQHAPTNSINLSTPPPALMIAPKPGSPKKSSTYKSRLLEVNSQHKVFVSFAEEGPELFAVQLVSDAKKLQDMMDDINKRPHSSLTEPPMIGTVCLGRMSGDRIICRAIVMNLSGSQCKLFFVDFGDTEMVSYYDIFDIPDEFVKPNVFAMRFCLSGVKKLEKGLHLNETFKQLVNGKVMTLKVVAPEGPPLIQYGELYLDNKNILELLMANMKDKLQFKRIDILPLGSRRSVLVSYVDSCIKFFVQLSDHIDELNAVMDAVRTHCENSSSPGELPVGAACCARFPDDNNWYRATVRDTKKNKVVVMYVDYGNEQEVEVSDLRTITPELIRLPAQAMKCALKGYENKPVETKTSNQLEMLALEKTLTAHIVGMLSTTMVVSLIDETVTPPLDVARKMTQLSQPRSSHEAKATTPVRKDAPETFSSPDSASDDGKKKSFRREKSFKDEWRPPKEGNEEFQQRGGSFRNRDNRDGFDRSGPGRHSEKFGGRPERGERPYNDRRGGPPKPRENVPSSVGDDEWEETPSQPTTFQPPHRQNRDRDNNPREYTPRDRDSNPRDRRKPRSENQHDKPGQRPGWKKDSSGVGKRLRQAAEAASLDAQNAPTKGASIQDRLKRDNKHNQHDDRDDRPQRENRFDRSDRPDRSDRPDRRDNRDNRGDRRDNWGDKKENWNQKRDFRPNDRAPRSNFSPRDRAERSFGSDDKKSDKSFRSQDSGRDRVGRAPPYKSRSKFTQVQYKELPNPVPLDTPFLEPTAVEPGAQHEVSVTWIINPECFFAQIMALQPKFLEMMHKIPEIYKGVKSYTGEVPVGGSVLARYPVDGVLYRATIESVQPFSKFIVRYVDFGNKQLVDAKDIWQMDQQMMELPKMAVCCSLSGVMPVEGEWKPNNLDMDLCFNAPRYQCIFQEFVEDRYKVSLWNNGVSVADMLVEKGLAKLSEHQSSVTLKDEAIDLTIIVGQQILCRVTHVESYEKFFVQLDMDKAELVEDAIANFDTSKLTPLTADNLADGIHCTVKHDGKINRAILENVADPANITAVLPDYGKSITTSLENLMILPTELSVYYYQSLQCSLNNYTEEAKKLMTLEELKAKLTGNKVIVYINHVEEITLVTTLYDCVTGQKIAVFEPDEGAYDEVIQLCMRSVFNYNFGMAYIAHAENLNEFYLQKASDGDKIALLLDELYKFYEEGTPEALTTFEVDGICAAHSADGNWYRATIISVEDTQVKVQYTDYGNTETLSKESLKVLDPKFYEPCALALVASLGLVALQEDALAKLKEWTNEKEVQVTLAIGTDGWLASLHLDGVDLSVKLVNEKLATPQINAVEEEKVEETQTAVLSEPISLPEGCTQVYISHIDTPGHFWLQMSEKISKLDELQAELQNTANTFSNLENPELGTWCIAKYMADDQWYRAEILDSDSDIITIRFIDYGNTDVLDNQPGLLKEMPAALKDVEAYAIKSSINAVPTGTGQWSEASSEYFTQLVGDLANAVDALIVLKDVITYVDIYVQGNNVTDKLVTAGYATRSEEPDCGDLPSCFASHVNSPSEFWIQLETATAELQAMEAAMVDAENFPELTDKEEGVICAAKYPEDGAWYRAQVIVDGSEGTEVLFMDYGNASIANELRSLPDELKVKPALSRKCALQKPRDVKWSRQSEIRFNELAAEGATIFNVQFIASGDISIVELFHEGKSVTEDLLGLCEQIAAPRPAPVGQDIFGSGKICFVKGLDEFYVQLDEVNTDLDKVTVRMNDFEEFEPATDLKIGSICAAFWAEDEQWYRAKILEFCDVGYHVQFIDYGNKAKCEEFRKLPDDIASIEPLARGCRIMLESGDESLQEEGKNKLDQLTLDDITVCIEFLDSTVSPSLVKLSYGGQDFYSDLKSSNANNHAEEATKEEALPSSEHEVVKVPEAATASDIATSDIDTLESLETLNEQNTSQADLNESTESNHTVIENKSFETKQDNLSVEINADELKASENDKPSDNAEVTELSEPKNSTETVEAENIEQASAQVESVEQTAEIKSDVNETEILVAEKENPAKEDDKAKSVVTEDTDKTEIKENDVEKPVDNVTEPPGSPVKNATDSTEKVTEAGDTKTEPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Z8</accession>
    <name>A0A835L8Z8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein cortex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Z8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF52">
        <property type="entry name" value="PROTEIN CORTEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49330" checksum="D7360D6CAC841B04" modified="2021-09-29" version="1">MNRSTFGKKTLNGQRPRVDRFIVPREQFPELCRKIRWGATDNGTHDVWYSKYLQQKKYASYLDEAFGLEPMKTEPSQADDDESVQLWPCIPRKRRYLSSADSILDLPSYSYAAFPELLDWSNDNILVAALGRNYHKWSWRTQSLISQGVTDYEIHCCKFDPQGKLLILGTGLKSVEVHDNAQSKCIERGLCSCLDAKPPYCSITAVDWSPTGNSFITGCSQGMLSAFTRNSQPISWCQAHHNAILIVRVSPDARYVTAAAVNDDLVCVFSWPGLQPVSTLKSDWTIKALTWHPWRSALLGIGAVSSSLQTRVALWDAPTGKLRKRTLSRNQYCLDAMLFSKKTGELVLSLWNTFEDRGSLPPKPCSQLVVLSDPETMVDQWGEGRQGLDRVRTMVFSPDGTKLATATADEDLIIWNFLPMTRGNERSPARGSPRYQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9F5</accession>
    <name>A0A835L9F5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Intraflagellar transport protein 140 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="7">
        <location>
            <begin position="3"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="8">
        <location>
            <begin position="410"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="10">
        <location>
            <begin position="739"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1340"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1362" mass="149336" checksum="C9CE3AD4F3F80B2F" modified="2021-09-29" version="1">MTLYIDTKLSFNDGNVVSTVGTWHPSLPLLAIGSYNQEKGGFVTIFQENGLPLEGCDWPILLSNQVTALAWHPIRRLLVVGWDGGELYIWLEYSWARLEAPHNAALTSVAFSLGGGRLLASDAAGSLSGWQSGAGAPLTSFHHQLGDVITHITFCTPRPSSETSIRGLARAAVAGDENALDALAAWRPRTTARMREGAQPDNHSCYAAQDNGVILFIDHNGACSEVLNAPGNIIFMGIISNIYLLVAWESGGALSLTRFVMSDDGSLMTDTHVRMAARNGQCIVLAGNFYVAVITGDNLIRVWDSDTGDNDVLPNEKEEIVAGDIFTSISYSNLSDTLCCGTSQGNLYLWRRDHRNNWKLISSTSVKGTVKEVSWGSEGLMNPLLHVNCITSAFVLREQPVCWGYSPSIHMVQKSANEIALTGKSNVTSMINTSITIRAFAFKDQYIALGDGKEVQIWMCNKDNDIKFSLIRSFLWKTDVLIIYNDVLVGVVNPHIECYSIAGTSLGILPSTEGEGEPIGVTNTSKFIVIATMDGTLKLAEITKKGLRMPYPPKNCYQMIEDFGEVMRASVNCTGRYISLSIANAGLAPDPRLYLWDVANDVITHTLIAENSTPPYQSVPIAILWDSNDPRIVAVHMRSADLDRIHLFLCHEGSLHEYRNWCSSSEDYYMSDFMLCSLYTPYVVILSQQNIKKILINEFADIGEHDPANIRQVLDFLYYMTTGYLEKAVVVGTTLTGGKNSIIWDSLAKVCVARKRPDVGAVCLGKMGNIKGALMMRKVMSDDNMDDTCKVAVLAVNLGMIEEAEELFKEAQRPDLITRLISAKEGGLNEITNGTHEGENILLIKSAQHKLAKVLWSNGETGAALKLFESAGTLVPHVPRMLVAQGQSAILAQYVANSNDASLITWWGHYLESIGDLDGALEAYARANDFGEQTRLLCHQDRIDEAEKLCQKNRSSLYQMARYLEMQPDKTESAVKMYIKCGAVSSAIRVAAEASAWNLVWRAGSSSPTHALHAASILENAGQTEQAIALYHKAGKVHMALKLAVNSGDTNAMIAAVDALGDKVDPELANTLAAHLRQANQHSHAAALLATAGKYEEALDIVEQIPTPLTEELSERLAAPAGTTGRDALLRRLADVLGARGLYHQAAKRLAHAGDKAGAMRWLMRSGDADRIATFAAATRDRNAQLMAADYLRRRADWRTRPDLMRHILHFYTRAKAYGKLAAFYAECAKVEVDEYENFDKALDALKEAIKCLAKTSDTDTGAQTTALQEQSAIVKRFMDVKKMLETGEINPGVVAGQQLLRAVIGRPGLISEEKVLRLLLQYAPNHADAPRFENQLKALQQQPEEHSLSPDSTDHSIEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9K5</accession>
    <name>A0A835L9K5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9K5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="208" mass="22565" checksum="8C0F07B337A53565" modified="2021-09-29" version="1">MRVSKPSYNKYVMAKDSKLINETVHQFAGRTFGRPLKKMAQALIPLAFQIGAASTWAVVAALVGVKTLLVALAILKLLLIAGAAKIGALFGAKTQGHGHGWEPPHQKEIHLHIHNGGHPEVHDEHILPGWKQLPYQAQNVPWRYNRFYYVTAGWNRDGAATATADKNINLVINPYAATAAAAGPQTISTPYGNYVRVDSPSALSNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9L6</accession>
    <name>A0A835L9L6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">YLP motif-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear protein ZAP3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000658</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PPP1CA and NCOA5. Forms a complex with ILF2, ILF3, KHDRBS1, RBMX, NCOA5 and PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9L6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000399">
        <property type="entry name" value="YLP motif containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="116"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="459"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="619"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="689"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9424265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1063" mass="123719" checksum="8EE54BED822F3E2D" modified="2021-09-29" version="1">MAWPMPPAGQWGSGLSMTPEINMANMGSYTAEQWAVMQQQNWQQWTQWQQQYAQWHGQYGDKFQKWEEEIEKWKKDNVNHPDKQAYKEYEQKFESCRAQLMERRLQMKQKRARLMGANPPIQPDPPTPSTTASNITPTVNANLNTTNINAFPPKQTQSHGNNLQNYGNNNLQNYSSNNISHYNNNSQNYGNNSQNYASNQHNYNKNQQNYSNNQQNYSNNQQHYGGHQQTYGSHQMNYPNTSQNYGNNSQNYGKNAQNYGNNLQNYNDSSSQNYSDKNAHYQEDQFKGPKTANSMGNKNIDPQDRFESYQTMGDTDYQTNTNLSTSTSTAPISSTFLPSSGDNKGIPGLDLVPETDKSYTTNTNDDVIDISNDKSNQGSHIKAPDYTIISKGINNILGDEKIMNILSMVRGQTTQSPGTMGTSNPPPSSQYNSNNQNSGSFGQGRNLSSQIYNNQQFDNNRQNMSSNRQGLDHSSYPPPNRMPEEIPQDQYDYDNDRNVQYSGNNLRPPYQNNEPPRHAPPVRPNIPAPRPPLRPLMSNMSDHLMARDFIEPVHTFDYNHKSKDGEVRKKDFEKEVDDLFQKKSKRLDAENDYGRERYSRDHYSRDFERRAPRYEVDLLDEIRSRGPPRSDYDDRRRDRYDDRRRDDREDDRRRDDREDDRRRDDRDKYLRREDTFRDRDREYRDRDFGRESRREEGRYRSRSRDRDSRKRGLSKESDSGKHYSKKPKDKDEPPLSASSSKHIVMIDDLLESPGRSMRPDKIVVILRGPPGSGKSYLAKLIRDREAEYGGTVRIMSIDDYFMQEGEVEERDPSTGKTVKKPTLKYEYDASYEESYLTSLKRAFKRTLTDGYFTFLIYDAVNEQLSCYADIWNYARQNGFQVYICTMELEPQVCYKRNIHNRTLEEIEAISSRFFPTPLHHIQLDPTTLLQSAAITEVQMEDADDVQIVMEDSQETEVESVFTSKWEKMDDAAQLARLDGTSKPLRPSQLSMEDYLQLDDWTPNKAQPGKKSVRWADIEERREQEKMRAIGFVVGQTDWNRMTDPTMGSSALTQTKYIERVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBA9</accession>
    <name>A0A835LBA9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBA9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000026">
        <property type="entry name" value="Apolipoprotein D-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032420828" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="287" mass="32312" checksum="A61BB6A9A54D3F70" modified="2021-09-29" version="1">MWRLLLLTIIATASAQIPSLGWCPDFQAMANFNMNRFLGTWYEAERYFTVTELGTRCVTTHYTATPEGRILVTNEITNSLTGFKRIMEGHLQKVGREGEGRVMVKYSSVPLPYDFEYSILDTDYDSYAVMWSCSGIGPVHTQNTWLLTRDRLPSLAVMQNAYAVLDRFKISRTFFLKTNQADCTILPEPAAVSELKNADVPVVAEEVEKEKVVEQPVEKGVEPEVKAVEPEVRSAVPAEIAAEEANKPMQVPELIMSESEKKEEKIEKIEEPAMIAEIKETKEAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBI6</accession>
    <name>A0A835LBI6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026053">
        <property type="entry name" value="HPS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761:SF1">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="2">
        <location>
            <begin position="447"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="602" mass="66838" checksum="A215CB7601F1D460" modified="2021-09-29" version="1">MKAALVFDSVNDLVFGKWDDVFIERMKKFSVQAMSQLLAPIITSQRVMAAQFGNTYSSMQCKDKTTIVFDEWLDHVFVIISEDNVDDAHRELLDFKTFVQHICGQNVNLLHSSIYQDWLSVLLESRTKGDTIPGANGVIGESGATMAALNALKSASKDIKLPYQHSHLMLFVGDKLLALYSSRGSEDLSPPDLILLSIQCIAAQEYWKEVSNEDSDENDPQIVRLPWLSTENSAVVNLCAGPTGSPCAPHSIHLAEVAPRITFAVVVDMDLREVGVSTYMANQILSNLRRLLLQRNLELLPNTLDALETALKKTTDALRKNKANSNLCARLTSRMLELRKSCTTTTPLTPETTATAMHTALEAVIEQLKPDIPSLKMEQPLKNLRTTLAPYVEFLCVKAKRYFSLGSYPFHSIFTIIYFNLFALWSTSESDASCSLTLHKYVEEFPGLIHFIYVDRTAGRFLAPDMADCADMLAPETVRRAVWRSLCVVREGYCAGTWRRGALHACALLWWERRAQPVRPVAPPHPAAVRALPPPGDIQGSFYRQLTELAFPGDSRGITVKELICIHLGLLPASTAVQQARRLAHSVHELAGEIGTGAADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBN9</accession>
    <name>A0A835LBN9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBN9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="91"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="296" mass="32707" checksum="FDAA73ABE1C98217" modified="2021-09-29" version="1">MDMKEIPKWTGLHETACLCGVIEVLEVIGFGVKMDRPSTSRQSVEKVEMFEVREHVPYQAELTRAPAAYDEESGDVYDSSWTSAFRAMCQLINLLHHMQVAIVVFCLWHFALTAEANGSISNLELHIIFAGTGYQLFLVEAILTLHRHNSWSFQLSKDGKRIVHGCLQLIGSLFVIAGTFLGLARVDMVVSTPHGICGVIALAFTLLSFVSGIIALFSAKVRLMVRSGPVKIIHLAVGLFAVSMGLITIVLGFHMDFYAASREGLSSALIVFTLLILVYIMIQPIYDLVTNTRKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBT5</accession>
    <name>A0A835LBT5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF13">
        <property type="entry name" value="DOPAMINECHROME TAUTOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="511" mass="57912" checksum="6073271405C219D4" modified="2021-09-29" version="1">MAVSHQWFVQWSAPPMIFADITSQHNDVNDRWKSDVPTWSNPAVVPELSVDSYNDRDSLIDSNHNPNDIVVRVDVSDRANAAGVTLWLTMLGVMRAQSVPADNDTPPFSTLYKWKQVDFEFPTPRHRRHALSSGKFIPANVLPLGLEVWGHRVWVTIPAWRRGVPATLATLPRQGGLASPQLKPYPDWSFHRAFGDVKNCTGLTSVFRIHADHCGRLWVLDSGQIDSQDNPKQLCPPSIVVFDLKTDKLVARYTIPKQFVLQDSLFSNVIVDSRTADCSDLHLYIADTWRFGLLVFREKDQQFWRFSNPLFFPDPLASNFSLHGVNFQWTDGIFGLALTPIDPYEERILFFHPMSGYREFYVSTEVLRDPSRVNNSSQEFNIAGESRGLNGQASASAVDRTGVMFYGLVSRDSIGCWNTKKLYKKTNNGIVASNSETLIFPNDIKVDQDFRQNLWVITNRLPMFQAGPLDADDYNYRILYADTKEAVRGTVCEMDTGHSSPADIVHRGWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835FZU2</accession>
    <name>A0A835FZU2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000995">
        <property type="protein sequence ID" value="KAF9404396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835FZU2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF22">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="43229" checksum="7FEB56C9CB070927" modified="2021-09-29" version="1">MAKEKFDRSKPHVNIGTIGHVDHGKTTLTAAIATVLAKHGGGDAASYADIDNAPEEKERGITINTSHIEYETDVRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRNVGVPYIVVFLNKMDMVDDEELLELVEMEVRDLLSEYDFPGDDTPVIAGSALKALEGDASYEEKIMELMTAVDEYIPTPTRDTDKPFMMPVEDVFSITGRGTVATGRVERGEVRVGDEVEIVGIKDETSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVAREDIERGQVLAKPATITPHTKFKAEVYVLSKEEGGRHTPFFTNYRPQFYFRTTDVTGVVELPEGTEMVMPGDNVAMDVELIHPIAIEDGTRFSIREGGRTVGSGVVSEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835FZZ4</accession>
    <name>A0A835FZZ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_014281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000947">
        <property type="protein sequence ID" value="KAF9404557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835FZZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004970">
        <property type="entry name" value="PRK06333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9404557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="412" mass="43356" checksum="41292F8316DE441C" modified="2021-09-29" version="1">MKRVVITGMGAVTPLGNTVKEYWQNLVNGKLGIAKITKFDSEDTGVSLAGEVKDFDPSGVLDRKEQKRMDLFSQYGLVAASEAWSMSGLDYDKIDPKRFGVIVGSGIGGMTTLQDQVRVMDKKGAKRVTPFFVPMVIANMASGNISIKLGAKGPSQTIVTACASATNAIGEAFRTIKYGLADMMITGGTEATICEIGIAGFAALSALNTTDDPTRASIPFDKERHGFVMGEGAGMLMLEELEHAQKRGAMILGEIVGYGSNCDASHMTAPLKDGSGAADAIELALAEAAIQATEIGYVNAHGTSTPANDAAETAALKRVFGERAYDIPISSTKSMTGHLLGAAGGIEAIACVKTLQEGKAHPTQGYQIADPECDLDYVTDGARTIDATYAISNSFGFGGHNGVICMKKWEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0D5</accession>
    <name>A0A835G0D5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_014076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000845">
        <property type="protein sequence ID" value="KAF9404961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0D5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18548">
        <property type="entry name" value="ABC_6TM_Tm287_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03254">
        <property type="entry name" value="ABCC_Glucan_exporter_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000854">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="190"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="412"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="554"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9404961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="924" mass="101930" checksum="D384F93F30D804FE" modified="2021-09-29" version="1">MGLYMVMRTSPTLGWFVLGALPFLLIAVVAIAKISDPLSTKQQKNLDGINGILRENLSGLRVIRAFVNEKFEEKRFSKVNEDYTNSSKSLFRLMAAAQPGFFFLFNIVMVLIIWNGSLQIQEGNLLVGDLIAFIEYIFHALFSFMLFASVFMMYPRAAVSARRIQEAFDMEPVIRENETGLTEAKTKGYLEFKNVTFAYPGHAESPVIRNVSFTASPGETVAFIGSTGSGKSTLIQLIPRFYDVSEGQVLLDGVDVRDYKLSALRNKIGYIPQKALLFTGTIADNMRYGKEDATVEEMELAAEIAQASDFISQKPDGFDELLSEGGTNFSGGQKQRLAIARAVIRRPEVYIFDDSFSALDYQTDANLRARLKKETKESTVLIVAQRVGTIMHADKIVVLNEGDVVGIGTHRDLNGYVQENMTGFSVLKLYGREKETLQGFKNVNHNLNNFGFKASFISGLMLPLVQMTAYGTYIGMAVLGSYYVITGVIVVGQLQAFIQYIWQVSQPMGNITQLSAALQSASAATKRVFEILDEPEEELNEQDVPLPETVHGSVVFDNVSFSYDPKKPLIKHLNFEVKAGQTVAIVGPTGAGKTTLINLLMRFYDVTEGAIKIDGIDTKKMDRSDVRSVFGMVLQDAWLYEGTIADNIRFGKLDATDYEVVDAAKTANVDHFIRTMPNGYEMEINSEGDNVSLGQKQLLTIARAVISDPRILILDEATSSVDTRLEALIQKAMDRVMEGRTSFVIAHRLSTIREADLILVMNQGEIIEKASADVFGNVKLAKDTSIWFQSVLRGDSNSITINKGTNIQDGSVIHVDHDAPVFIGENVTVGHACMLHGCTIEDGALIGMSSTILNHAKIGKNSLLGAGSLVTEGTEIPPNVLAFGRPAQVIRPLTREEIRKNKENAQHYIELSQEFAAGNYPKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0X5</accession>
    <name>A0A835G0X5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WxL Interacting Protein peptidoglycan binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_014469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001055">
        <property type="protein sequence ID" value="KAF9404186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0X5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07382">
        <property type="entry name" value="MPP_DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000016">
        <property type="entry name" value="Putative metallophosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="WxLIP_PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00282">
        <property type="entry name" value="TIGR00282 family metallophosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 2'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 2'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="WxLIP_PGBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032660340" description="WxL Interacting Protein peptidoglycan binding domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="WxL Interacting Protein peptidoglycan binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9404186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="472" mass="52330" checksum="88C9A28DB6503FFA" modified="2021-09-29" version="1">MKRYISAILIVIGLISSCFLGNQITSAAETNFSAKAILPEKQWDQKKTYFDLRVKPGEVEHLEVEVKNYTDKEITVAVQANSAVTTDGGIIDYETTNPEMDETMSHPFSEIVEVDSEVTLAPNETKKVSAKVTVPEESFNGIILGGLQFTQQKELKKKDNKNKANQTQVIGVQLSENDNPIKPEINVMSVKAGQIDDNNMILAKLQNPAPKIIRDIVGSMGRDTLTTYLPKLKKKYRPQVTIANGENAAAGRGITGKIYKKFLQDGVDVVTLGNHSWDNKDIFEFIDDAKKMIRPANFPEGTPGQGLVFVKVNQLELAVINLQARSFMADLDDPFRKAEQLITEAKKRTPLIFVDFHGETTSEKQAMGWFLDGQVSAVVGTHTHVQTNDARILPAGTAYLSDVGMTGPYDGILGMKRQAIIEKFITALPRRFEVVEEGRSLLSACIIDIDDQTGQAKKIEPIQISEDRPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1M7</accession>
    <name>A0A835G1M7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000840">
        <property type="protein sequence ID" value="KAF9404993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1M7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="132" mass="15095" checksum="EAAD1DDF9376BE58" modified="2021-09-29" version="1">MREFSLAKAVYLKCIVCCRVKGQVVSPHMGNLLQQHLNLGGYQIETEGVDYAGAVFSASRQIQYRVRIGDTTASKMEVMFYTDQDFVGTHKESESSRKRYTLCRMKLALLLISGLRMEWFVERSAKSVPYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G202</accession>
    <name>A0A835G202_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_013195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000594">
        <property type="protein sequence ID" value="KAF9406428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G202"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9406428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="379" mass="43512" checksum="DB8F0C49E4C3CEF3" modified="2021-09-29" version="1">MALSILERFYLIDEGFFSFNIKYLFFVGLWPEKTLTRTQKILYKIYEIFIHTITILFLILSGIGTYQNKHDLVIFFSNLDKSLVIYKFFFKAIIFLIKRDELRDLIDEMEASGDEVTKERKKLMANYVMVITGMTAAVVFTFSVLALIEGTMSIEAWMPFDPRKNSMNLVLSLQIMAFCAFPGLCRAFAMQGLVCSLIMYLCDQLIHLQKELRSLDYVKDTEMVTRMKFKVIIKKHIRLMSYSMRMESIFNEYFLVQNLAVTVELCLNAVMVTVVGAQQITLLFTFLAYLIIALINAYIYCYLGNELIIQSEGIAQAAYESTWTSWPVDLQKDLLIVINASQRPLKLSAGGIALMSIQTFSQALYNGYSIFAVLNDAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2W2</accession>
    <name>A0A835G2W2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000699">
        <property type="protein sequence ID" value="KAF9405675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2W2"/>
    <dbReference type="OrthoDB" id="7470341at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9405675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36831" checksum="C5039F586DA1473F" modified="2021-09-29" version="1">MNKFIDTERLITEVRLREPLWNISHVLYKDRDAKLKAWQEVCEALFPNFDEMTLTEQKDIDKTIQQRWRTARDAYTRSKAAIINTKSGSGGGAIKKKYIYYDHMRFLDKKHTVQVEDSLMADDSQTNISVPDFEPEPEPQPEPQPSTSTIFDTRVFEQKNTEPASQTSQNKKNRRITKSKRSINKEEFEFDKQMLQMFKENSTILQNDDMAFFTSLLPITNSFSISQKLTFRSEVLKIATKIHDGDNALSRPQSQSSSTTYFVTSPESYSSHSQTSNNITAQESEQLLTNIYPNMLPVMVSNSNVEQTDFSDLVVFKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G351</accession>
    <name>A0A835G351_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000628">
        <property type="protein sequence ID" value="KAF9406198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="941"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="261"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="367"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="7">
        <location>
            <begin position="441"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1304" mass="140666" checksum="12571DCCB05BA6C7" modified="2021-09-29" version="1">MILTVAYLQVQSPVLVVELNLDRIEGTQLRALGLLAVYGFNVTYEVRAAAQAPGPTSCSAIECRLLGHCYASHDYQEFYCSCFDGYSGADCGVGPLCPTTSNMCKNGGTCRQMGPAAVSCICAPGYTGDLCEAQVAPPECGIEECAEVCKDGTACDCNPKDTDALSARFETRLQVVGLPNENISDEIAKQLTQFLKASNITLEDNVQVLNTSVTTTEGIRDAWVRVWSSRREAPALRAALARLASARTRLLPTTTHFEMHPALSLHKLVVNQRPEVWEGSEFILTCMAYGSPNMAFTWYKDSVKINFNGTTRDIWTRTVSEDALGRRMSVLGVTEAERLDSGKWSCAADDAGRRRCRALRLTVLRPPEIRLVPSTLTVNRGDNVTITCLAGAGRVHGALGFSWARERTLLPMAPGREVWEDLFPAGSVLKLYNVQKSSEFRCQVSSVAGTNAKAVTMWALGSGDAACESDASHGLRWPKTVPGAHATASCPPGHSGETTRFCEPKTGEHGVKWRLPDFSGCVADSLRDIYEQFTLISMGYSWGSVSHVSRQYGAVLRSLPTHPGEGEPPLTHAVHMLNYLMSPAAQPPDRYNSTGHLLNIYDNLLKHPDAFLDEEKIFDLQNAVVDTAGLRSSFNKRYHEFTVMSKPVLEDNAAHFDLQPALAEREEWAVTSAGVELVTKTENASVVTALYHDLGARLPSLKRFVEYKSGRATQYTIASQQIQLSVSGAGVDNTLLHTVTLLFTHSKNNSAIGPQLACGSRSRSSPRVWSTHTCELRVQEQTYIACRCRGLATIALFTVDSLGLTDAESDSRAIVKITVSLGSAMCLVAALLQLLSLVVGSKTRLPVLLRAATAATHSAAMLTLLECDTKQTSACVGPLGWAVAACWCAGCAALCAQPLLLHTELAATATRAPSVGLLAGVSTLCWLTARLWGGAPLQLGAAANAVCGAGAALLAALTLCLALCAARTLRTVTHKLPPDRREYVQERARVVRHTLVLLFTTTATQIAGVAYAQPGERTIPKVVALSVAALANGLAMLICYVICDEECLRAARRLLTLSSNNEWHDSPEGDTSLSLYIRQGREMECRGAVGSLECSSSHVSPANTYWRATPLQSPLHRRGSSGACVADIVRCVEYKQALLPPRNVHSRTLCDLIPIGGAEPRVSRVCVELGVLPEASQTTVTDASTFQPPSDTSDISKANCTLCAKSTPDVSATSTAPRPIKSCLKKRSPQLSWSTSLPSINHESDESNSHLQLVDTQSQTPSTHTTFTQTDKVLHKISHDLDFLLNRTPSRVGQLSAADEEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G354</accession>
    <name>A0A835G354_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000484">
        <property type="protein sequence ID" value="KAF9407324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G354"/>
    <dbReference type="SMR" id="A0A835G354"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00301">
        <property type="entry name" value="lipocalin_FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032673531" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="212"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="372"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="555"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="734"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="939"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119284" checksum="C6FCEC06325E0843" modified="2021-09-29" version="1">MGTNDPTMSKLNILVFSLLGLISACVGQNVITSTSNCATIITDLPRLPNFDARNFIGTWYDVGRYYQPTQLGQCNRALYGTPNANGQIAVQNWQVVNGEWVSVSGTATANAEGVLSVTLNTASGVQTAELRILTLTNEYAVLFSCRNEGTGSILGTFSTSTVILLHHKSCTVQARPYIELTGACDASFKGVSGFQLLNYVGQWQELRRYPQPTQTGQCNRALYEASEPGVVSVTNSQVLNGELLTISGRAVPGSTDGTGHLIVNFGGDRNSNYYVVATDYENFALVYSCTNEANGNRRVGSWVLSRSGSLSATAQATINQAIIDTPDLFDGYYQTTSQDADACFSYPTFDSKWEYIELPGDCDTRIKGVDDFDVTRYLGDWKELQRYPQPTQTGQCNLARYGPVNNGVVTVVNQQVVNERLATITGQAVIASTDRTGHLKVTFNVNGEVRESDYYVLATDYNEYALVYSCAPAGNGNRRVSSWVLSKTGTLSDKSINEIDETILKTQGLHKGYYVKTGQTQQDCFYYPEFDSSWSYVELSGECDAGIRGVSGFQAARYLGKWYELARYPQPNQSGQCNSAEYGSLPNNAVSVLNSQVINEELSTITGQAVLASSDGTGQLSVTFNDPANPSNYYILATDYNEFALVYSCRNVEGGKRRVGSWILSKTGTVSAASQAIIDKTISDTPGLTKEYYQPTSQTYASCFYYPDFTEPQQYIELPGPCDTSIKGVANFNAADYQGTWIENARYPQPTQAGQCNRAKYTPIAGGAVSVTNNQIVNTTISTIDGIAIAASDDGTGQLEVSFVANNELRRANYYVLATDYKQYSLVYSCYNVENGNKRRVSSWKLSRTGVLSDEDKAAIDAVVEKTQGLKNTYYVETDQSSETCFFYPTIAPNSEVIIPGQCDESITGVAQFNLDDFKGNWYQIRRYDPVSGTCAGVRFTPETDSIDVVAYEVFNGELFIAEGTARINSTDNTGRITITMPVEGSSEPVETVVYIMATDYNNYAVAYSCANVGNIQRRVRVWQLSRERTMSEVGNTAIAALVEQRQELHLPYFKDIAHTECPEPSSAFLFKSSIVVLLVCAVLQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3M4</accession>
    <name>A0A835G3M4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000573">
        <property type="protein sequence ID" value="KAF9406590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3M4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="11189" checksum="DA2FA04645E94C47" modified="2021-09-29" version="1" fragment="single">AILETVDMDETRRLNLDFTSIIPYLERTRRYYRMKTDAQLISLQATGCLSIYLPGCFCKAGYVEDQEQCVKPETCAPDEMNEEYFQRIVLESFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G448</accession>
    <name>A0A835G448_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G448"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="54720" checksum="19BBD9C833C49319" modified="2021-09-29" version="1">MREKIFVSVPTNPKRRKMWLQLARRDPKNVLSHTNIFMCEDHFDMEQDTTNYLKYKMGFSQKILLRDEAVPTKFHCQEDRKRRLSPEAGPSREAFLKRQRRSLVTECLESQSTTETEVESIQQLDNIIQDAVMLEETSKTQEKETSTETIITLEKSVQVTTKVTKHFRSKAVQVRIQNKSISTSPLKVCTTSSFTSPFKIEPCRLQPSQSGAVKAVKKKIVLEDDKSDSEISCLESGHSSPFVPTATSSSSKMTDSEKLEDNFGISLSYASKIFLSNISILSSVLNPFIVALDKKNIIKNLPIAFRHNHYNVSCIIDCLEIDIQKPSKALYQALTWSDYKKGNTVKYLISCTPNGLVKYVSQGFGGRTSDVTIVENCSFLNGLQPGTIILAGLYTWNLYFRQKNEIIKHLLRAGAKLTKSEVKQTKIIASLRIHIERVIRRLREFHMLKQHSVINTNICRVLDHIIIIACALINLQDSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5A3</accession>
    <name>A0A835G5A3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000629">
        <property type="protein sequence ID" value="KAF9406187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5A3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112008" checksum="5BACA8C4FFE03F96" modified="2021-09-29" version="1">MFSKNEMLDAEVSPSNMIEQVSNNNCNEESAKSAETDNGLTDDGGSEHEGETSTEIIDSASSPDTQSEVIDNSDDIVDVESNELAQTRDDCDNNASLMTDAPFQPTERSFMEEDRERNNRDEIVSNNSKERVINDISQEDFEPINVTNDENCADNANDMDSLTDSSNNINNFVKPDNSGFHNDGLSGNSNGIREEPCSQEESFIENVKPPGINQPTKQIRPLSLDKAISSIKDNLKNRFGNIKNTKAIPKAAKIYEEQIPNNYIEEGQASSTIIDNQQSSNCQDVEKLQVTTMKPVICDDEPKVNDESADKVSMQDLQKISDSMLQREEQERKSKAACDEFSTVERQPKMSTADNSKENHKDSEISANTQKIVIMDPREFEGNDRSDEDSKKSCQSGLTLPKQAEEVHDASGSASEVVASIMPQNNMVRSPFSFDKVVQPNLDLLNLPVPNLKDLIKIEPIPTFDEIKTGLDSLLGTRASVAEEPKTLQQTMSTDASTKSFRSRLPLGLEDIDLDILQLKPQTSLLKKLPKLELPSKNKLLLPDLQIKPLKLQSALNDKGILAGRKNPLDIFPNLESPGSRMKSLSRKTVKASRKPDVLRSSLNPTKGIEDLTEDLQSHAKHTLRHMQKTLQSTLREQTKIPTKMQSNDLLEAIARNHEDVSDKLKALHMDFNDRLETMRNNLFDSSLFESRAPEPFSSLSSNIKERKSSLKTAQPKTLTSRIRDSKKSKSRRPDQQKQSGFRLSSQANENKFRMPAAASVTVPKTLKVPTLKPIMPKPLELLKQKPMISTSKDDVSRVKAALPVALWKKESEKVNPNTRLSKINPFKDSKIEVTFSTTPRPPMPRAQFRKLTLPSSLSDRNTRRFGVLDNSGSPSNMRSAVVSSPISSQDYKLGNEAVDSENRQESLTRQQKLTGNGIRLANSQPKISTDLESWPKASESAFLSKVKDAVKARLSKTPALKNSENIEVSDSTDMLRAASENVGVVENKVLKENVSYKCTMVCTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5F7</accession>
    <name>A0A835G5F7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000327">
        <property type="protein sequence ID" value="KAF9409242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5F7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="19292" checksum="5DD10A6C3EA3816A" modified="2021-09-29" version="1">MVHGYSPYHWCLVSECKKTSVKTPEKLWIQVPTDLKMRNTWLKLARRDPKSLSTKTKYYFCEDHFDLENDMENYTQLKIMGSVKRIRMRPNCIPSRFDCQPGRKRTFTEKQKSGLQAKNFVTINVFIRGRLVLSAFTKPSSMVNIYSIGAEYQETPLVLTARSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6X4</accession>
    <name>A0A835G6X4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000432">
        <property type="protein sequence ID" value="KAF9407827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF4">
        <property type="entry name" value="GH03113P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="272"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="451" mass="50605" checksum="CBC874D46B4F157D" modified="2021-09-29" version="1">MDVRKSLVRDFVKGELRVRWYKDKILLGDSHTPEEPLPPRVQMHSNYSLQVDNLQTQDTADYTCEIIRPEPWGPIKQTHSIEVLFSPTVPEDGFLEVRMGDYVDIGCETTGTPPPIVDWRKNGEPMALLEHRSRIRFRAEHRLLAGVYECIANNGVGDPARATITVVIQGKLCPCSQHQTVPTCILLVGLRAALAAKLEFAVPPARTAWYRDGRPVRTDDRVVQMVHDNVHHLIFRSVRKTDFGNYTFRAENKLGMADLMFKLTGVPNAASFKVDPNLNKATATSFTLIWEVDSYSTIIEYNLWLRPYYGRLVTPEPDAFTTEPPANHWIKIIVPGDSSDGPIHSAIYTVRGLTPSTVYEAIVTSRNRFGWSKPSSILHFATEPGAGRTRPSTADYSEITPILVETEPEPYNISQAQVFERLNELSNGARETTSLAAILIYDPDAFAGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Y2</accession>
    <name>A0A835G6Y2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial uncoupling protein Bmcp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_007156</name>
        <name evidence="12" type="ORF">HW555_011873</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000382">
        <property type="protein sequence ID" value="KAF9408438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000511">
        <property type="protein sequence ID" value="KAH9636204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Y2"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000006">
        <property type="entry name" value="brain mitochondrial carrier protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="198"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9636204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33032" checksum="878B34AF1482FB21" modified="2021-09-29" version="1">MGDRDWRPFIYGGLASIVAEFGTFPIDTTKTRLQIQGQKIDPRHVELRYTGMVDCFVKTSQQEGVKALYCGIWPAVLRQATYGTIKFGTYYSMKKWIAQHRADGGSIEHLPTNTFCAAFAGGLSSAIANPTDVLKVRMQVGDEKRGLVRCFMEIHRLEGWRGLWRGVGPTSQRAAVIAAVELPVYDACKKRLTVPLGDSPLNHFASSLLASLGSAVASTPLDVIRTRLMNQRKLKGQAPKPNERIYRGTVDCFLQTVRNEGFLALYKGFVPTWLRMGPWNIIFFLSYEQLKQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7D2</accession>
    <name>A0A835G7D2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000359">
        <property type="protein sequence ID" value="KAF9408816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7D2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="262" mass="28915" checksum="1C42AEB35BA845CE" modified="2021-09-29" version="1">MSCGAECLSLGPPPDSILHMPPPPLPAFLASAANLTPPCRASKCPPHRNNEENSLFPGVEYHELPRHGEIQPATNDDTWFLVLITCCIAVLCIAALLALFLLKCREARGGCKSGTGKASGSNALYGGAAIDSRVLWAALTPRGTRHFVADTYPHDETEDHHYECVEPPLYKLGPPEDLAIPRHFNVEYEDPAPLIESYSDRTEEYFRNGMDTLRRGNRPLVSSPTRIERPNLPPLNLQPRTLRRAPHSRRVSDANNPEKSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7K8</accession>
    <name>A0A835G7K8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NTR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_011499</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000346">
        <property type="protein sequence ID" value="KAF9409017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7K8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03577">
        <property type="entry name" value="NTR_TIMP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030490">
        <property type="entry name" value="TIMP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00288">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="4" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033029294" description="NTR domain-containing protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="13">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9409017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="21849" checksum="9A6D34DB76D27923" modified="2021-09-29" version="1">MKSIRYSMLTRWLALALVVACCRVADACTCPPAHPQTHFCNSDFVIVGRVQKTFRGKDFYDAYKLKIRNTYKATPKAKVALQSGRLLTPSQDSLCGVSLQPRETYVITGRVVHLEAHVHLCGFVSKWREVTPRQRKGFRLLYKQGCTCKVHMNRRRSKSPNACTTGYNECYERHGICLHDREHRCRWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7K9</accession>
    <name>A0A835G7K9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000311">
        <property type="protein sequence ID" value="KAF9409543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7K9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="737"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="781" mass="82944" checksum="C91C05CDB808DCC6" modified="2021-09-29" version="1" fragment="single">APTEARPLSSGLAGQEAPVSSQPPPPVRPLNRQDSRSALPPQSPRPAAPPSQPRPQFQPGGPVTTTPQFAPRVGAPIARGPAPAPTGPPGTQQVRPAQPTVRPFGPQSIAPQQGPRPIQSPTGQPLQRAPPPNNLQFGPRQPPLVGATTPDGGRPQIAGQQPNGTIRNGAPPVPGVQRQPSQGSLKGLDISNNYQTKSANLDNQNISSENPNVPKAENGIEGPGVAKGRSYSIAAAPGAPSPLKTEDDRRKSVSAIGGRIDEFISRSPGLGLIQEGKLESKENVRESKESLRSEVSNEGGKEVPERPESRLSGSKMTESFIGALPTPKKKIDDDDDVILQNNLTSSRNVTETTKPKEEFSDRSPSLTRSDDSPEPKQKPSMSPSVPIKSQSITPEPARPKTPKAEPKLDPKTDSSKETKPVTPINKTPSKSPLPDAKPPQQVPKKPNDLTSPIGSADVKKTPRKTASAPKSRPKDGDNDSGVDESTQGNDVNGSPASPNKKIPSKLPMKEKSSHSLKTSLSRSSSKSATAKTPENPPPNEKKKVPMNKVQVGNAPSPNIKAVKSKIGSLDNATYKPGGGKVKIENRKLEFGNVTPKIAAKNEAYTPSGGVKKVIKLFYTTQKNVCKHAVIDISLLTISVFQIVSTKLEWNAKSKVGSLQNTAYKPGGGDKKIETVKLDFKEKAKPKVASTVNITHKPGGGAVKIENQKLEFKAQSKVGSMDNVKHKPGGGDIKIFDDKEYIKQMSGQSPVPDSLGHSRQESPVPAASQPPKSDENLNQQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G855</accession>
    <name>A0A835G855_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G855"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="137" mass="15803" checksum="FB9BBDDC0C2AD0F0" modified="2021-09-29" version="1">MTDFEKELKKNPTNSSDTTQGITVEFSAFRSFAMQALTRLQEQVNFLVQTIDTMVMRRRRKILLLHGVPETKEEDTAAVVVRVVKEHLKLDLEVPDIKRSHRMGRLTQKLRPILFKPHNTALRDGNWFGKTSLKGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8C0</accession>
    <name>A0A835G8C0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">HW555_010797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000284">
        <property type="protein sequence ID" value="KAF9409995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8C0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF37">
        <property type="entry name" value="INNEXIN INX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9409995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="389" mass="44431" checksum="411FDC84044D0536" modified="2021-09-29" version="1" fragment="single">MAVFGLVSSVAGFVKVRYLIDKAVIDNMVFRMHYRITSAILFLCCILVTANNLIGEPISCINDGAVPGHVLNTYCWITYTFTLPNSPARGIVHPGLGNDYEEEKRIHAYYQWVPFMLFFQGLLFYVPHWIWKNWEEGKIRMISDGMRGTAASIADDKNNRLNRLVQYLVDTKHMHNTYSFGYFFCEILNFINVVGNIFFLDTFLGGAFLTYGTDVVKFSNMNQEQRTDPMIEVFPRLTKCTFHKFGASGTIQKHDALCVLALNILNEKIFIFLWFWFIILSVVSGLALMYSAAVILLPSTRETILKRRFRFGTPAGVESLVRKTQVGDFLLLHLLGQNMSLRVFGEVLDELSRRLHMNSNAPSAPSTLEMAPIYPNIDKYAKETETFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8V4</accession>
    <name>A0A835G8V4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000261">
        <property type="protein sequence ID" value="KAF9410492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8V4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032422153" evidence="5">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="129" mass="14066" checksum="805A4B2940CB45E3" modified="2021-09-29" version="1">MKSFVVFCIVLVVGVCANEKGNKLASECIKETGVKNELLEEAKKGIISEDPAFKAFTYCFFKKIGIVGEDGVLNRDVAIAKLPSGVDKSEAEKLLDSCKSKTGKDAVDTVFEIFKCYQQGTKSHIMFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9S0</accession>
    <name>A0A835G9S0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000321">
        <property type="protein sequence ID" value="KAF9409400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9S0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000005">
        <property type="entry name" value="Arf-GAP domain and FG repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="5">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="352" mass="38878" checksum="AC7E61842B816281" modified="2021-09-29" version="1">MAANRRKQDDKNLEILRELISLNGNKYCLDCNQRGPTYVNSTIGSFVCSKCSGMLRGLTPPHRVKSISMATFTPEEIEFIKARGNDYCRRVWLGLYEGESVNFTDEQSVKDFMSDKYEKKRYYLDSPAITNNPVNGSSMKNKPKVKTGSNALNATPLISISPQTSKNTINNNTVVQTAKVVNNLLPANDLSYRVAQPVNSLVKPIMNTVNVTPVPAAVPASVPDFPVDFSTANIYNSSQINNNMNNSFATPPSMNSPAFNAFSTPHQPANDRYAALADLDMALRQQNMKHMEENNVVNNKNPFQSTTTNDLFASKNPFFNGGWSTATATVPVNPFMQSTNNGGFMNSKNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA50</accession>
    <name>A0A835GA50_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA50"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="46933" checksum="8C51D98249C84D7D" modified="2021-09-29" version="1" fragment="single">GPSKTKKADCVKVDGCENCIQRELRSELYQELQKLECEHEYQSYIFEKKSAEYANGRLLLKSAVSSDWFRILDEYIEESSEPAQIHDLLTQFNQTPSFASETSTVPRQFLLQLIECVFRNQRPVVETPPVPVGMEESPLLQSLAGFTRRANPINHMSTDVIQTMLEVLRNSAALTNERSLNESRAKELLNTERSRPSASNVSNNNFGQFINGHTTDSATLASITTPTRYPCTTNITVRTFASGMVNTVASASSHSHPPTAVYLTNAPHLPNTPLLLLHPVHRLPLIQRRPLIPRLLPILQAHHIPDCASSPYASHPPTAPQSHVRAVTTPSTYLPYQPAVPPPPTRGYYPQAYPSTSSSVQNAHQTYPNFPVRVAVNPQMARSSTATTATATATAPAPSAHNAQNYNAYLMARYPPQPPFGPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAF0</accession>
    <name>A0A835GAF0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="28940" checksum="D7E2791D49533B1B" modified="2021-09-29" version="1">MESKLAASFEAMKATLLSRMTAHEEKLEKVTAGNQPPADIAGLQSEYSDFKRFVLDALHSFGTQIELLSQGYDRHETVMRRKVLLVHGVPEAKQEKLPDVITAVLHDRMKLTEVGRSNIHVCHRLGHSNRGPRPILVRFFTTEHRHLVWDNKKSLKGTGITISEFLTQMRHRAFTAARKHFGLTNCWSVEGKIIIIAPDKSRHKIEYMSELEELITKFRRCSSVGDDTVPAGDPNLAGGGDPLAKTLRRTRNARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBF8</accession>
    <name>A0A835GBF8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000188">
        <property type="protein sequence ID" value="KAF9412462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="20452" checksum="3460DC40813D3BF2" modified="2021-09-29" version="1">MCLAKAQEYIENLHDSKYGTHIRDLPKSFEVRGFDANTQFQKYFDRIQEIAMQGNLNVVYKIKLEIEKPSKYHTKKVLVKKVNSKKYNIPLKKTSMKLSNFEVWLRKMAEQSGLNKKGNQQNQDLYPDVTTEGEKLITTTKQMQLKFKPIISRIKTNYTKFVKPVRSRTITLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCD0</accession>
    <name>A0A835GCD0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCD0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032760997" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="137"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="43110" checksum="66DAE57447458819" modified="2021-09-29" version="1">MLKYIIICLCVGLSGVIGDLNKEEGAPCEWDGVQGQCVKETRCLTTLDTRGDKHLVCSKQGDVNIVCCTDCLLVNDTRNVVMSPQTGYFWKDGTKARDACLEYLKTLPYRCRDGGFYSLITKSFDEEKKCHNVGLMGVGGAPPPGYEPGAKYPHQALLGYGDSLETAKWLAGGSIISDKFILTAAHVNNYSQTKKLQFVALGVKRLSDPASSWQVHRVKRFIPHPEYKASNRYHDIGLIETEKPISFNKNVLPACLHVAAVEDNTAIATTWRDLENYSQFADTIQTINLEKFTEQECNSAYSSHNLRLKEGIDYKTQMCYGSKTQAPEACKGLSGEPLLVERQFSTCIYTIIGITSFGSARCDKASLPDVFTRVAYYKPWIEEQVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCT1</accession>
    <name>A0A835GCT1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000197">
        <property type="protein sequence ID" value="KAF9412208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF10">
        <property type="entry name" value="PROLINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="437" mass="47872" checksum="35BE8918DC6C5975" modified="2021-09-29" version="1">MRYLSKLFQPVITIPKNAKIKNTEITCKSQKLLLECGLIRPTGPGLFTILPLARRSLDKLETLIRSCIEAAGGQRMAVPSLTSASLWDKTGRLQEIGPELIKMEDRHGKKYLMAPTHEEAIADLLADVGPLSYKQLPLLLYQIGNKYRDEARPKHGLLRAREFSMMDAYGVHESERCARDVYCAVTEAYNTMFKTLQLPVHRVEAPSGDMGGSLSHEWQLPAPAGEDSVYICSGCAGTSLQGGPCHKCGGETKEVQSIEVGHTFLLGSKYSAALSALCTPSSGPPAPLYMSCYGIGITRLLAASIEALSSDKCLRWPDAIAPYSVCIIGPKEGSREWQTHGIGAISELYQTLKPARPGDVIVDDRHQLTIGKRLMMADRMGYPYIVVIGKAALSNPARYEVYRSCDATASVQLLTTTELLELLSNEDTQRIKINNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCW8</accession>
    <name>A0A835GCW8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000213">
        <property type="protein sequence ID" value="KAF9411777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCW8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="36447" checksum="40163B4F34BED3B0" modified="2021-09-29" version="1">MHVRVHYWSSKPAARTLILLSRWGSCSRSIMSGRWGRMQSTAPAATSRASVPPLASSPPASWGGSTSRQPFDRFYRNIYLSTLTLQNELYQYKQVIIRYGGFGPQRLHELVHQDPADQQLVSVPTEYPRTKHQAIFGNALNSSFLEANPVAPLHLFFFVSLLILRAVMMDPSRILSLTLYAKAHHINETYIDRQGLLRVEMFHYQLKRPTRVQLIEVHERLRNALEEHLPLFLCYKLIFNGTIIYDVCRTPSSHLKSYGINIRTRRALQEDLQEDVVGRELVQHAAQELVRHEHRAARQPSVGLRLPRVVAQLYHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDC6</accession>
    <name>A0A835GDC6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_008718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDC6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="15341" checksum="19EAC6C53CEF6AFC" modified="2021-09-29" version="1">MVRVWFQNRRAKFRKQERLAQQKAGEAPVKAEGKRDKPTSPAASPHPPAAPAPQPAHHALPHLSPPDLKPITSAGRYPNKLCEELNGVGGDVGLPPVSGSGGGKWTGGCGLLRQPSGFPLLGVAPPNYLLSDHLGTLAKSNNHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDW0</accession>
    <name>A0A835GDW0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9414004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDW0"/>
    <dbReference type="OrthoDB" id="10061449at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032269157" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="284" mass="30394" checksum="FDA15B162178C35D" modified="2021-09-29" version="1">MFASKSIVCTALALLAVTTAAPGGNDIQKITKAPNVPTKSEAVSKASVLEPQPVNERFPHAVLFGGTCGGTIISPTWILTAGHCTLFTGGRYILAGTNNTENDSGITRRVKRQVIHPLFTVGPYWLDADDFNLKQVAARWDFLLAELNEPLPLDGKTMAAAPLNDQPNLPVGLNVGYAGYGTDHFGGTMRSDMHGMELAVQSDEVCSSLEQYNNKDMLCVKGRPPRYDSACNGDSGSGLVDETGKLIGVASWVENDAHECKNGALVVFSRVSSVRGWIKQVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE22</accession>
    <name>A0A835GE22_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Osiris 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_011832</name>
        <name evidence="3" type="ORF">HW555_008393</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000162">
        <property type="protein sequence ID" value="KAF9413352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000073">
        <property type="protein sequence ID" value="KAH9644663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE22"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF14">
        <property type="entry name" value="OSIRIS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032527608" description="Osiris 8" evidence="2">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9644663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25589" checksum="FD4F42352A544DB4" modified="2021-09-29" version="1">MVKYLLLLTLVAAVTARTANTAQNKLEGRSSDDNILGDLKLAYETYKDCSGSDISHCLKRKLAKTLSRLTKAEELNILNGVTITKDKDVQITEKEEAIPRGMDEGSLNNLILDKVVNFMRSHTLQVKFPTEDETDALSDQGRSRRKKLAPLLAIPLLIGGMMVPLAFGALALLAGKALIVSKLALVLAGIIGLKKLLSPSGGGHEAHEVVVSAGHSGSGWSRSLEKSSHDLAYNAYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE44</accession>
    <name>A0A835GE44_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000103">
        <property type="protein sequence ID" value="KAF9415747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032603418" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="17"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="198"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="52365" checksum="57F2A477545F48AA" modified="2021-09-29" version="1">MLKILPFFILLVTVSCENSNVDALIDQIFGPTTAKVTQEPNRSTVTVDQGNKTCTTPDGLEGECVVYYLCNATNSTPEPIIDLHFNENECVSYVDVCCHKSHRLSDDHYKTLTKRSPFNEMKEKMAENPTVPDPTPTAPGDTSKGEILCQTRDGKQEQIDVAAVKENVCSSYMDVCCEDVDKLPYAPLEREGCGWANPAGLSSIKVPPEETRFGEFPWMVAILEKVPLKENDPDSEKLNVYIGGGSLIHPSVVLTVAHYVHNKTDIKIRAGEWDTTSTKEPYPYQDRQVASIEIHKDFIKRTLFYDVALLFLAKPVELAPNVGVVCLPAPNVPQEEGTRCLATGWGKDKFGKGGHYSTVLKKVVLPVVNHNSCEKILRSKTRLGQVFSLHSTFMCAGGERDKDTCTGDGGSPLSCPIDTDRFVQSGIVAWGVGCGEDGVPGVYVDVSTQRNWIDDKIIGKGYDPKVYTYVHKGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEG9</accession>
    <name>A0A835GEG9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEG9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="10">
        <location>
            <begin position="410"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="862"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="985" mass="114306" checksum="46C987D9D33CC650" modified="2021-09-29" version="1" fragment="single">FINMRHAKSKLTSEEILKKKREAEKARLARIKSDPIKLAEYKEKQKLQYLKKKEKGQRKNVEEMTPREQRITRKKWKNYSSNYRQRKRQLKQTTNNFIRQNSPPLTDDEIQPIINEEIRPLKTKLNTQRQKYKRVKKQLKKVIKSVEKTPKTRIEDMSEDITKKKELVKKALFGEVIKTQLEENYTKLKTHEERKKFKQVISGNLVDKYKLWRIKNKAVTYKKTGHNLTNKKINKSKTIIQGLVQKFFEDDSNSLRLSCMIFLLEEAKRRDNVEKRRQAHVIRNMDLITTDTEFIKVFRLTEELIKQLEEDISPFLAKTKRKGGICNRTKILCTLAFLASGSYQKILCENARTYISQASASRAIRAVVNAINHPAIINKYIRFPQNTNERQILKEKFYEKFKMPGTIGCVDGTLVSMVRPKEHEERYYCRKGYHARNAVIINDPDLNIMHVDVTFGGATHDSFIFNNSVIKTHLEQLNNTGETVYLLGDSGFALRPYMMVPCSNPGPGSKEEYYNDLHATARNTAERTIGILKGRFRCLLVHRVLHYDPEMVGKIIKACCVLHNICNQARVPPVELPAHLQTRSKCDPKRYLLDTMKNLHKKFLKTTPCVISYSLFTRLRPFWVVPPTLSNRETCSCTIHENMNLQLAALKKANITTVSNHQNMLELLCCDRYSERCLERTCDNCCSKTLTYTEFDNSKPILIKQWVSKKESITDLKTKKQRFVMKCKIETQEMSPRNAITKLENDMVKFFRHSFNILHQCPGIKIDVIEECQIEKMNTIINDKSSEMVAFKGTLLVHQVTGTAYIPNNLTMKSLSCFCHTDGCNHYKLGSISYQTEISAINSTRINTSTVFSDSEDDVPLSTYVKDNDDRSKLDRDLSAPGTSGYSHHQSRYSSGDYVLVKYITKKTEYHYAAVCSSVDDEDGEVRVTFLKICDQNGTLFKLDERDVSDVPMDQVIKKLPVPNLITKGKRVYYQFQEKIDVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEP8</accession>
    <name>A0A835GEP8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(S)-3-amino-2-methylpropionate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
            <ecNumber evidence="3">2.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-AIBAT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_008509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="4"/>
    <dbReference type="EC" id="2.6.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000168">
        <property type="protein sequence ID" value="KAF9413155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047298">
        <property type="term" value="F:(S)-3-amino-2-methylpropionate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9413155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="499" mass="55984" checksum="186A1701FD1AD567" modified="2021-09-29" version="1">MRRRLTSLSRSSLTALFAKERRNYGISYCTEHQEPPCPQIKTEIPGPKSKELFKEMMGIQQCGSVQLFSNLERCAGNYLADADGNLLLDTYTQISSLPLGYNHSALLNAFCCDSDVRALVNRPALGVFPSDDWPQKLRDVLLSIAPPGLQHVMTMMCGACSNENAFKAAFILYCIKKRGGKTTFTDEEIKSALQNIPPGAPNLSILSFKGLKNNGAFHGRTFGALATTRSKAIHKLDFPSFEWPVARFPEYKYPLEEFKCENEKEDKECLANVEEQFERWEKKKPIAGVIIEPIQAEGGDNEGSPEFFQGLQKICQTRGVGLILDEVQTGCGPTGKMWCHEHFNLPSPPDLVTFSKKMLTGGFYFKPEYMPPQPLRIFNTWMGDPSKLILLEKVIQVIKNDNLLQLVEETGKVLKCGLYKLECEFPAMMNSVRGRGTFLAFNVVKPNLRDNIIKTMKQNGVLGGACGVSSIRLRPALIFQPKHAEIFLDILRKTLRQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEX7</accession>
    <name>A0A835GEX7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="23572" checksum="1AABB661B9FD5727" modified="2021-09-29" version="1">MANTKRHTFSLLKACPATVAGHGSRACRRSAILAKRLELTPREQPVVISLQCVSESTHDDDDELYDRICVVAAAILNKRKEKMKKKRRLWMENINYFRKECSEFKLFYELTNDAFRTYFRMTKDEFEYLHSLIEDDIKKENTNYREAIGTRERLVITLRYLITGTTYTALSKSYRKGRSTLSEIIPVLSRFSQNPKKRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG51</accession>
    <name>A0A835GG51_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG51"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="511" mass="58224" checksum="0955C88EE9368241" modified="2021-09-29" version="1">MSNPTSRNMNKLNCPYICPNAPPILEKSSYLQAGQKKSHENPFASPYVPGLIQPPEKKYYPADAPPHYLPQQMDSTSGDILGMGPIGPWAAGHVDWTPQAGMTGVRPVVDKYSITRYSTGEWRRNNLHTLTPRATDKAKALDASIKGDIAKALKDMDDMQNDSNKKLKERVKNLAHWKKQVQNTLKAISQEIQTLDADRDKLKSACRILMLPEAISRECLELRTFRYEPDLVRDDAEQELIKEVSIVGEIRRVFQDTLAKVEVQMAHNKAAKAAIEFDWSDKISTLKIDNRNLNLTSESNLILHHPGVARWPENATSLEYWEHFCKESIRNCEEVRKKSENLRGDLMTIILKGSQDMKTQADRTNLALAETVSATEQLCVKLEETLKSNLQTIADVEKLIDYLKESLRKVDERDKLSNTRLRNRNYGRPHVENCRDEAQYGLMAEAKFIKETSESLKGKLREAEAVRAELMKYRGELEKDIACKRKSLNIDQDRISRVRAHLPTPEEFADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGF8</accession>
    <name>A0A835GGF8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_003343</name>
        <name evidence="11" type="ORF">HW555_007374</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000123">
        <property type="protein sequence ID" value="KAF9414841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000058">
        <property type="protein sequence ID" value="KAH9645013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGF8"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000017">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9645013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8502" checksum="17C207B1715BAD71" modified="2021-09-29" version="1">MSKAHPPELKKFMDKKLSIKLNAGRAVTGVLRGFDPFMNLVLDESVEECKDGQRNNIGMVVIRGNSIVMLESLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGN2</accession>
    <name>A0A835GGN2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGN2"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9417227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="23896" checksum="A5AF33329023047A" modified="2021-09-29" version="1">MAKATTIKEAIKKWEDKTGEQAATATEVSLMFQWPPIEKMDNTLATLTNCEKLSLSTNMIEKVTGLNTFKKLRILSLGRNYIKSFTGMESLGDTLEELWISYNLIEKLKGIHVLRSLKVLYMSNNLVKEWSEFNKLQELPHLEDLLFVGNPLYDGCELEAWRSEAARRLPNLKKLDGETVLREDEPPLTVADMQPDCGDGVETLVSAETND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH53</accession>
    <name>A0A835GH53_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH53"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="8480" checksum="1E9957EC41F488EE" modified="2021-09-29" version="1">MYLNSRFDQSDGTGRDEYGEVRNAGSEDEFVAVKGSYSWVGPDGVKYTVNYVADENGFQPTIEQGPGGAVPSAVVASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH90</accession>
    <name>A0A835GH90_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable nuclear hormone receptor HR38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor subfamily 4 group A member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_006820</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms a heterodimer with USP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH90"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06969">
        <property type="entry name" value="NR_DBD_NGFI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000009">
        <property type="entry name" value="nuclear receptor subfamily 4 group A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="351"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9415612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="567" mass="62223" checksum="D5BEAD1C6C0A2389" modified="2021-09-29" version="1">MFAEGPSAIESRSPSAFTPNSSSMLLLQTHSNYGSSFTDLLSPQYQEDSTEILEENLDPFPDVEFHAPVPPEVKSHRTTPISEASSPTLGPALPSFEETYSVRYPKQEMAEFGIKMDEDCYNVSAYQGHTSTQLLYQYHQPSIPYVPSTYYAPAQPCSPTFDTGGVTPSQDSYSLPPFPSSVDLHIATDQSARQRRASLPVQRSESTSSNDSPKIPGGRVHCMQASAPSSASSSPGVAPEGAGPRVAPSSPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLAEKSCPVDKRRRNRCQFCRFQKCLNVGMVKEVVRTDSLKGRRGRLPSKPKCPQESPPSPPISLITALVRAHVDTSPDFANLDYSQYREPNPMEPPMSDLEVIQQFYTLLTTSIDMIKVFADKVPGYGDLCPEDREQLFASARLELFVLRLAYRTRPEDTKLTFCNGVVLDKRQCQRSFGDWLHAVLDFSNTLHSMDIDISTFACLCALTLITDRHGLKEPHRVEQLQMKIIGCLRAHMPGGGGAAGAALPTSAACWALCPSYARYQCRACNASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI76</accession>
    <name>A0A835GI76_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="49440" checksum="770894B7E8012C6E" modified="2021-09-29" version="1">MPSSAEAFVDALLTQEALDQPSDKVKPEELVLELPKWFDEEKFNKGRRFYLDNCFAMSSSMLLGLVAVFSIPSILRILVGTRRSNSVYTAYRRYLSTLLHTISWFENELKPGSISWKSLYAVRSRHLRAGLASKIKGMGVVSQRDLALTQFGFIGFSMLKPDKFGIRQLHEDDWEAYNYTWKVLGYMIGIEDRYNIVRDTFDETVEVCKLLQERVYTPCLENVPEYFEHAARVMLEGLWTINPTIETDGLLYWCRVLADVPGYIYTEAERIEFQRKIKEKLKGKSLDTGVDSMEFMCKPAIDGLPTIPPRLLYYKDFNTIETSPYYKHLTFKAKYKMYMYNLYSTLYTSYLGRLYINLNFWFSVFLMRYFPYLAFFKFGIKNSLVNIFEEDPTDETKPVTNAEYLKNRKPEPWYSAALSLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GID2</accession>
    <name>A0A835GID2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_004356</name>
        <name evidence="12" type="ORF">HW555_006204</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000757">
        <property type="protein sequence ID" value="KAH9631589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GID2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032922993" description="Superoxide dismutase [Cu-Zn]" evidence="10">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="11">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9416443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9631589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="173" mass="18338" checksum="AEC13BCD515B25C2" modified="2021-09-29" version="1">MFKTLMFVAAAAVLASAHDDSIEVKQAIVKLDGNGVSGLVKFIRLDDGKVHVTGKVTGMPAGQYGFHIHESGDLSNGCISTGGHFNPNGNDHGHPHDENRHVGDLGNVEFDNTKTANIDFVDPQIKLNGRHNIIGRALVLHQGADDYGRTDHPDSKKTGNAGGRVVCGIVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIR2</accession>
    <name>A0A835GIR2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIR2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="287" mass="32657" checksum="BD5A4658B33D3405" modified="2021-09-29" version="1">MPWRSVETIDITDVVLKGNSLVATVSVTNYNIPFVTKTSRELIIGGVVGFQVKVVTAMISNGHMTVYNNLVFVQFIKRRQNDELNYVLKLTATDLNIEDKRFTSDDGTWHLINENKRLQYTFQVNILLEVVPRVNSFASLHDDEELTDFELRGVDGSVHMHRAVLAAASPVLRRMLGGVWRETKEGFVDMPGTSRATLQDLKNYVYLRTLPETGLEELLLLSSYYMMPELEERCVDKLVQNVTAENAFEVIEFAAKNKMTQLMLAVLECVESGLVHVSEMRNHLQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJB5</accession>
    <name>A0A835GJB5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJB5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="246" mass="28561" checksum="F98D4ED21C36542E" modified="2021-09-29" version="1">MFNRIPDRAACKFKQDSAMSRGESQHYTRDSTVIVKWRDNKSVIMASNCTGSSSGTIVKRWDKKQRGYIDVAAPKIIQQYNQHMGGVDILDQQMEYYRTFIKTKKWPLKVIIHFLDLALVNSWRLYKNDCVANGYPRKDILTLLDFRFSVADTLTNFPEKDRRDDGALDSENVPPPINRQYRPIRPSLGKRYDGYDHVAVFDDIKAPRSCMMEGCHSRSKIKCSKCGVYLCLSRNQNCFQLYHLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJH5</accession>
    <name>A0A835GJH5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000078">
        <property type="protein sequence ID" value="KAF9417054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJH5"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="29935" checksum="EAD648D1D1BC35D3" modified="2021-09-29" version="1">MAVGKNKGLSKGGKKGVKKKIVDPFTRKDWYDVKAPSMFTKRQVGTTLVNRTQGTKIASEGLKGRVFEVSLADLQADTDAERSFRKFRLIAEDVQGRNVLCNFHGMDLTTDKLRWMVKKWQTLVEANIDVKTTDGYLLRVFCIGFTNKDSLSQRKTCYAQHTQVRAIRKKMCEIITRDVTNSELREVVNKLIPDSIAKDIEHACRGIYPLRDVCIRKVKVLKRPRFEISKLMELHGEGGSGKRGEAGDKSERPEGYEPPVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKB6</accession>
    <name>A0A835GKB6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKB6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="42302" checksum="8A44978C7CDF9A3C" modified="2021-09-29" version="1">MDNSSKNKYSSHLVLTAVLTGGITITVSLVYILLSIGALIYRFSDCKNVEPTHSGHVFWAVTVGAYILEDDRCEISQLVRHNTEITTAYTVFVLAALTLSFHALCLISAICLIIVIQSVEAARYLTYVVPTYIGTCVASLVVDLTTAAHFGIDHSTLRSKLANVLLEDSKSQLDIDNIYILENLRQGALYMMTFALKGYVAPFINIILIILLIIYVMEHRKLMKSNEHSIHKMGVLSGFDQPRRPDDNNWAVQNEAMSPYARGPRTNNAFINDDESDRSSRQPNRRQLTRNDFNNSNRSYDRSDSWHHAQPNLAQSARPFSYLEDIRRPGPVKPPPSPAVEVPWNRDSWQQGPPVPAPDYSPQPRRLKSALKPGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKD6</accession>
    <name>A0A835GKD6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKD6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="87"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="425" mass="46674" checksum="396B454BCAFCB2C0" modified="2021-09-29" version="1">MTWGFVTCGPNEALVVSGCCYSKPLLVPGGRAFVWPAIQNVQRISLNTMTLQVESPTVYTSQGVPISVTGIAQVKIQGQNAEMLLSACEQFLGKSEQEIQHIALVTLEGHQRAIMGSMTVEEIYKDRKIFSKKVFEVASSDLINMGITVVSYTLKDIRDEEGYLKALGMARTAEVKRDARIGEAEAQAEAKIKEAMAEEQRMAARFLNDTEIAKAQRDFELKKAAYDVEVQTKKAEAEMAYELQAAKTKQRIKEEQMQISVVERTQEIAVQKWEVQRKEKELDATVRRPAEAEKFKLEKLAEAHKLKTVLEAEAEAEAVKVRGEAEAYAIKAKAIADAEQMAKKAEAWKEYGSAAMVDMMLETLPKVAAEVAAPLSQARKVTMVSCGGGEVGAAKLTGEVLNIVQCIPELVKGVTGVDISKLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKM1</accession>
    <name>A0A835GKM1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKM1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="20061" checksum="D9889097523BEA9E" modified="2021-09-29" version="1">MERMALEDQEEILEVASKSSNLKGTFQKALKCRAASLLGIVKELAQRTTSDETRQLQAKVDRLQKEASALHARVAELMTRPEGTSEGPASVPTPSYLEDVVRKVVMEERAFTRACFAAIEDRLLPEKRLRPPLAADKVPETHSAPGPSTAPARPPRLPRRSLRIVRGRTHSCPPPPLPTSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKT7</accession>
    <name>A0A835GKT7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="307" mass="35472" checksum="553BA167EA833AB7" modified="2021-09-29" version="1">MIREFYDSSDEDDMEKQYQIDQECLVTRPDCDMHNRCCGGKAWCIRDICGIICAVLTWLLILYAEFVVMMVMLLPGVSTYPVYSYINIFIFQSLAFLAFASHLRTMFTDPGAVPKGNATKEMIKQMSFREGQLIFKCTKCCSIKPERAHHCSVCQRCIRKMDHHCPWVNNCVGENNQKYFVLFTFYIAAISVHAVGLAVYQFVTCIRHEWRDCSAYSPPATVVLLLFLIAEALLFAIFTAVMLGTQLHAIWNDETGIEQLKKEQARWVRKSRWKSIQSVFGRFSILWFSPFTQPSPKTKLESYLYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKY7</accession>
    <name>A0A835GKY7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKY7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="370" mass="41688" checksum="F2C1DA1A9CA2DCC9" modified="2021-09-29" version="1">MVQNKRILVIYTGGTFGMLKNEKGVLVPQKDIERRVIRKLPQLHDNAYWEKHLAGTDLKEYLVLPDGKDTEQKVLYKIYEYEELKDSSDFTMDDWITQARDIKKFYHDYDGFVVLHGTDTTAYGASILSFMLESVGKTVVLTGAQIPIFQPRSDGNNNLLCAILIAATQNIPEVTVFFGARLFRGTRVKKVSNTKIYAFDSPNFPALLEAKSTLDVDPKMLIHPPGSVPNECRLHDKLCRKVYILKVAPTITPELIKAVFSGMEGVVLETYGNGNIPIKRKEIYKEIEAAVKNKVLVVNVTQCINGTVIAKPLYETGLLLLECGVVPAYDMTAEAAWAKLSYVLTKTELSYEEKVKLMKTNIRGEMYNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKY8</accession>
    <name>A0A835GKY8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HW555_005201</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BAW_Kor-Di-RS1</strain>
            <tissue evidence="23">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04270">
        <property type="entry name" value="ZnMc_TACE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034025">
        <property type="entry name" value="ADAM10_ADAM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF3">
        <property type="entry name" value="KUZBANIAN-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="22">
        <location>
            <begin position="276"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="21">
        <location>
            <begin position="508"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="969"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1054"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1169"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1140"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1169"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1195"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF9417787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1310" mass="145941" checksum="FE7935D6E4E16801" modified="2021-09-29" version="1">MELLREFKLVLRPDPSSVFADGVQFHSTAGQVDFNPAKVYSGKLEDDELSHVYGVITAEGLFDGTIWTPTEEYYVEPISRYNIDHPSMHSVVYRRSDVEHPHDANEGAPCASHLLHMKRTLGQEVELFSSADQRNVKDSHLTNFTEDLRSEIHRRKKRWLPEDEMQDDEPKKNPELPLDLDFPYTSNNEPVDKLSTRKPKTKIDKSNLITKVRLDSEESRPKPKTHVEVIKTKAGVVAVNKDIVKKEPVGYTVLSANATDDGRHVNKRATVDPRKTTCLVYLQADHMFYQRYGSEEACIEVMTRHVQKVNAIYKVTDFNQDGKPDNITFMIKRIKVHTLDALKDPAYRFPNNYGVEKYLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSMKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEVCTPFGEDGNYIMFARATSGDRKNNNKFSPCSLRAIDPVLNNKARSPKGCFTEPQPAICGNGVVEEGEECDCGWASECTDVCCRPQAARPHYKPCTLTEHSVCSPSQGPCCTASCTLKFGDKCRSDNGCRDAAFCDGKACQLSRQPAQAQQDAECTGSICLAYGLESCQCAPRKDDPRSACELCCRKPGGVCMSSFEWNTAPYDVPDMYAKPGTPCNDYNGYCDVFQRCREVDPSGPLATLRKLLLSDESIAGFKRWVLKHWYAVLLILLAVVGLLVASTRFLGRHGKKLKSVTIIHSSTTETVRLPDAADQGLIVHTAVRSKLPLKKKVALRTRAYRNKKDHKKLGDKASPMHSANKKRKPNSQAKLEDVPKIAKENTVIVTNAEGKSPKHVILSKHKGKVKKRKSKMKKEIIDYSSMQKHPSSPIKDTEALSKVQRWLLSSPQPTAIPKSKSIPVGLTERTHRQIQKGSRKTRPSKSATNLLSGEKARLQVVFKPPFRFSVKICKSDKTKVVLDKSSKPDVDRKRHEVAPQQPPADVAKANPSSKAPKPSNSMRIAEAAATPSAPKLEKLQNQENKTHDYANLLPRSASDCKLTKKMPDVKVNNGHKKSNSVGQKKETTESRQNLISQEDGENAHVYENVVLSQDAFVPKSCSMPRRQNSAGVGIARQSSYGHLPRAQIRPHRHSTNNISRSRNSSTSELEHFYNVIESLRRNNANDANTCNTNTSSSSSSSRHDSALLKHTSNSRHGGSKTSRQNSLVDKPARSSPIESSKLQRQLSEAELAKSQGDSGLRGFQLVVGKDKLKRQLSDNELCKSRVQLAMPMSAGAEPRQAFCWNKRASLDCEASLPAWAPRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKZ8</accession>
    <name>A0A835GKZ8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000267">
        <property type="entry name" value="PH and SEC7 domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF376">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="8">
        <location>
            <begin position="449"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="699"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="862"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="922" mass="100506" checksum="15B7959158DF3FC6" modified="2021-09-29" version="1" fragment="single">DNLGFGFSLLGEAGLPHIIYEIEENSPAARSGEVEAGDVLLKVNGTDVNRFTTREVLKCLRLSSDPVTLRLRKDPQIKASVRRYLAAAAERRSSGAGARTNHDSRSASPPSSNSNSNSSSNSSSNGSGVQSGDSCEALVGVEDKRRGRATPKFEAYMMTGDLMLNLSRVEHPHHNHHAPTHRTHYHRYNSTPASPSENRMCGRVELAQRHNSSPDTGLVGDHASKMFISQPASPAGGGAAASDVCARAHHAVRTSRSEDHLQSRVCNGKFQKESSLSAVAVEMEEDVTSSLNTLLDARPDSATPGPRSDSDPERDRIVWTYNAPVSCASERAACNGSARSGATSNSTSISDGMSQRLSEAVSNISSPDYQDQDDMFETGRECPRMELSDPSDSDSTILVSEPCHKRAKSNSSYSNEHGSDVTLNGDHSNDYRIVIQVKGPDKQNANVTENVNNNNNSNYTQNGKENGHNSPENQGYQELCSGSDVGSDEGSDGDSLHSFHYSPKAVDIPSAERLAKRLYHLDGFKKMAMLSSNEFSRAVAEEYVRHFELSGASLDAALRTFLARFALSGETQERERVLVHFSRRYLECNPGSFNSQDAVHTLTCAIMLLNTDLHGCGGGGTFRRMSCAEFIDNLADLNDGDNFPRETLKQLYHAIRTQPLQWALDAEAPPASQGAGAEVRVGGAGANPFLDVPDQSRAIEYKKGYVMRKCCVDANGKKTPFGRRGWKMFYCTLRDLVLYLHKDEHGFRRSQMSDNLHNAIRIHHALATKATDYTKKQHVFRLQTADQAEYLFQTSDSKELCSWVETINFVCAAYSAAPLAGAVGSQRKFQRPLLPCTHTKLSMVSSRAVTLYRRPGRAIVPGAVGGARGARGPPRGGARRAEARARPRTRRARAALSPQGALPRARGDVFSYCAPFSCGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLU7</accession>
    <name>A0A835GLU7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Indole-3-acetaldehyde oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HW555_003555</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BAW_Kor-Di-RS1</strain>
            <tissue evidence="23">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>indole-3-acetaldehyde + O2 + H2O = (indol-3-yl)acetate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18086"/>
            <dbReference type="ChEBI" id="CHEBI:30854"/>
            <dbReference type="EC" id="1.2.3.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLU7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050302">
        <property type="term" value="F:indole-3-acetaldehyde oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000013">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000008">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000012">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="22">
        <location>
            <begin position="214"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1035"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF9420142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1238" mass="136945" checksum="4B75F6FBF3601ED9" modified="2021-09-29" version="1">MDRINFTVNGDKYSLTGTEVNPETSLNDYLRNYLQLYGTKAMCHEGGCGACVVSVSQVHPATKEKHVFSVNSCLVHILSCHDWDITTIEGIGNRKDGYHAIQDRLATFNGTQCGYCTPGWVMNMYSLDKSTKNLTTQQVENSFGGNMCRCTGYRPILDAFKSFASDTDPEIKNKLQDLEDLHINKCTKLCTRKCSTSEEDWCVIENPEESMKVLRTSVGRWYKAYSIQNVFEVLAREGTNSYRLVAGNTGKGVYPISSEPKILIDISSIETLKQVQSDENLILGAGMSLTDVMKTFQKWSKNNQDFSYLETLYKHLDLVAHVPVRNVGTIGGNLSLKNQFHDFPSDVFLLLATVGATITVVNNDLNKVELKTKEFLTANLKDKLISDVKLPPLSSNNLIRTFKIMPRAQNAHAIMNAGFLFKLDTAKLIKSANIIYGNISPTFIKASQTESMLVGQNLFTNEVLLRALRKLEEETTPVEIPGEPSASCRKTLALGLFYKAVLSHFLDVNPRYKSGGSILERPVSRGTQSYETDKTIWPLNKPVPKLEALAQCSGEATYVCDINNGVRAVHVAFVLSKVCRAELEEFDASEALKLPGIVAVFSAKDIPGRNSFTPNEVPWMEFDEEIFASKNIHYYGQPIGVVAAVTRRAALAAAELVKVKYKKLAGKPVLSIKDALQSPDKEKRLRKDVTIEPTTKGTDIQHTVTGTFNVPAQYHYTMETQSCTTKVTENGLVIRSATQWMDLVHVAVSKALNIDENRILVEVPRVGGAYGGKASRSSLIACACALVAHKLNRSATLVMPLTQNMEAIGARSACEFQYECGVNNDGVIQYLNVTYYSDCGCNYNDSAGAGIAVCIPNLYSKESWKITGYSVLTDKASSTWCRAPSTTEGIAFAEHIMERISHATKKDHVEVRLKNLSPQHDTVREMISSFKMETNFDDRKVEITKFNQENAWRKRGLKLSIMSYPIGYSWNYPVTISVYHGDGTVDISHGGIEMGQGINTKIAQVCAYALKVPLEKVTVRGSNSFVSPNSMVSNGSLTSDSVAYATLKACEDLNKRLQAATNDLFEPTWEQIVNQAYQKGINLQATYMTSPNDGLIGYNVYGVCAAEVELDVLTGNHVVRRLDLLEDTGVSMSPEIDVGQIEGAFIMGLGLWTSERLVFKESSGRLLTNRTWTYKPPGAKDIPVDFRIMFRRNSSNPAGVLRSKATGEPALTLAVVVTHVLHDAIVEARSEFGYNNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM80</accession>
    <name>A0A835GM80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_006988</name>
        <name evidence="2" type="ORF">HW555_003765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000448">
        <property type="protein sequence ID" value="KAH9637344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF67">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN TIWAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9637344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="20214" checksum="918CF33EF403F04B" modified="2021-09-29" version="1">MQAVKAGSPLPEDMSLAVDSKLIVGIPRVATTTKDNAPVHIDVGGTIYTSCLETLTSYPESRLSKMFNGTIPIVLDTLKQHYFIDRDGGMFRHILNFMRYRKLLLPSDFQYLDLLIHEAQFFELDNMVYALTKVKVEREGIKQDREWLSEATERLKKETEMLMQERDRLQQRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM88</accession>
    <name>A0A835GM88_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_014050</name>
        <name evidence="10" type="ORF">HW555_003374</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM88"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9639186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="554" mass="59056" checksum="26D9AF0B57E3E236" modified="2021-09-29" version="1">MSTVATALSVAGTRTSGASVRTQNVMAAAAIANIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILKMLEVEHPAAKVLVELAQLQDEEVGDGTTSVVIIAAELLKSADELVKNKIHPTSIISGYRLACKEAVKYVQDNLTVTVESLGRASIVNAAKTTMSSKLIGADADFFSEMVVDAAQAIKVTDYKGNPSYPIKAINILKAHGRSARESVLVKGYALNCTVASQAMPKKIVNAKIACLDFSLQKTKMKLGVQVLVTDPEKLEAIRARELDITKERLQKILATGVNVILCSGGIDDLCLKYFVEHGAMGVRRCKKADLKRIAKATGAAFLTSLTNMEGEEVFEPSMIGEAAEVVQEQICDDQLILIKGPAARTAASIILRGPTDAYCDEMERSAHDALCAVRRVLESGRLVPGGGAVEAALSIYLENFATTLSSREQLAIAAFAQSLLVIPKTLAVNAARDATDLVAKLRAYHNSSQTKVEHANLKWVGLDLTEGVLRDNLAAGVLEPAISKVKSLKFATEAAITILRIDDMIKLDPEQKGKSYEDACHAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMK4</accession>
    <name>A0A835GMK4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="25487" checksum="2140654029724B9C" modified="2021-09-29" version="1" fragment="single">GHVRFFRYSYRKLALKWHPDKNPDNADESNRRFKEISEAYEVLSDERKRRVYDQYGKEGLNNGRGRRSAPDDDYDFGYPSFPFTFRDPEEVFREFFGGSPFGDLFPEINGHGHGHHRHGRRSHPSTSLTSSLFSPFGFGMQGLDDIFAHAASNGNTFTSFSTFNSSLAGPGSANMRSTTTTTRIVNGKKITTKKVTENGRETVMSYENGVLKSKTVNGVPQSLTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN24</accession>
    <name>A0A835GN24_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN24"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039932">
        <property type="entry name" value="Spink4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179:SF1">
        <property type="entry name" value="KAZ1-TYPE SERINE PROTEASE INHIBITOR-LIKE PROTEIN TYPE EPSILON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032520844" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="241"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="831" mass="91364" checksum="CBCF1FC1BD972E22" modified="2021-09-29" version="1">MKTFFYIAFAVLGMVVVESYGPGGGGHGHGWGHGGPWSHRGPWGHGGPHGHPWGHGPGPHGHEPEGPRGHGPEGPHGHGPGGPHGHGPMWGDSDENDSGPQDSDEHSFEKYDSDDDWYKPCKGSSCGRPDKSKDETKPPTAPTKEPPITTYHPPFTSATEPPTIPALTTEKARPTRTVPLTNPTMHPDPQPPPTKQAPPAWPTNPTWPTGPVWPTRPTVEPTTEIIPETTTDGEEGFTTISPEVESCIEACPSTPEFNPVCGTDGQTYPNEGRLFCAKSCGVNVSIRRRSVCPPPIDDGGPPTPATTSRPTTPVGRTTSFSQFQHCMKSCRITSTFQPVCGSDLVTYMNIDRLRCAQNCGQDVWAAKFSSCSSEPTPPPITSPTTIEPPPSTLPPHILTCIRNCPVTSEYDPVCGTDGLTYTNMGNLECSKYCGVDVKFRYKSRCFDEFDLRPTTPDIDGSKDVTQTLKPEPTTYVPPVTRPTMPTVTPKVTPRWSTTLGFTIPPDVLNDIFGTKSPPTTKKPINPDDEDEDLDLDSRFGPGHAIHSNQSGQHRAENDKSEQDKSEKDKAEKDKSDKDKHDNDKLETDKPKISDEEKLDKIKPDHDQSDKEREVSFRRPCRDLSPECLRKTVQAALPTIADGIPDLGIESLDPYELKKLQLKLPGGIDIAFSNGYAKGLKTCNVDYARYGGGLFETQMHCNLTIKGKYRSSGRLLLFPINGDGESIIKCRNLKLRSLIQLGSVVRSDGRRYFDIKDSRIEHGYDGRVMYSMTNLFKGSPEMSNAVLDFMNSNWKMVAEEFGTPMVEYGVQSVMKNVKRLFDVLPIDELEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNC3</accession>
    <name>A0A835GNC3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNC3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="22674" checksum="FA612C995EFAE1A6" modified="2021-09-29" version="1">MTQIAEVLSNQKSLEERFTPLEAMFMQKMEAVQAQIQAAGPAKDTIAKVAEEFRTFRELMFSLLGLLRRQITECSRQIDDMETRSRRKALIMQGIPEKEGEDCTGLVLDVINTKLGLNFTTTSIKACHRLGQTSADHHRPLLIRFASVDNKLSVWRAKTKLKGTKIAIREFLTKERQNAFLKARQHFGCGLAGLRMASYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNY1</accession>
    <name>A0A835GNY1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNY1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF25">
        <property type="entry name" value="GH14967P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="35000" checksum="FED41D9FF3767883" modified="2021-09-29" version="1">MVPMTQVVAVAGEPVYLPCDIATQDEEDAVLLVLWYREDLGTPIYRSLYNIFSLLFVLISLKGNLASTNMSCTRTFLSPRIHETTSKGFETDFVMNLCFVEPCLEIRRRPYLGTHSLRHTRLGGVTIFANVDARERDFGVAERWSDESVFASRAYFLPERRPAELGVDRVKASDQGVYRCRVDFKQAQTRNSRVNLTVIVPPNKMVITDDKGDVKQAIVGPYIEGDTFTLKCDVSGGRPRPWIKWFRDEVETDTPATPLSGNGVRGVLHVGPLTRADVRAAFTCRASNHPRAHPIETTLTLDMNSYISIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNY7</accession>
    <name>A0A835GNY7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNY7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="13652" checksum="C5D364D8A55EEAED" modified="2021-09-29" version="1">MDLGRHKRNATFPGGQTASLLQSSTTRKYSADASTLRDVADGCQASRPRYCSGGTTTWPGPRVQPPQPEIPSLAAPTPIDTKVTEETGPRSFSPIPQHNLTMIHTSLQNEGFASIKFSTVTINIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQD5</accession>
    <name>A0A835GQD5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lin-52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_014570</name>
        <name evidence="3" type="ORF">HW555_001533</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000648">
        <property type="protein sequence ID" value="KAH9633602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQD5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16304" checksum="BE6F58F154FEA2F9" modified="2021-09-29" version="1">MAAKQNPVVEEEQTTSDDIPLTSLEESLFSSEKLDRASPELWPEQNERSQCSTSSFAVPGVSEFAPPPSNNQSPPLWARGVTKEDFAYMQQLGSLSTSGLIMEVKKLHDLAYQLGLEEAKEMTRGKYLNIFSSRRPRVCYSKSNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRM1</accession>
    <name>A0A835GRM1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRM1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF65">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2, 6-BISPHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032867217" description="6-phosphofructo-2-kinase domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="457" mass="52573" checksum="0BBAA11CFDFF414D" modified="2021-09-29" version="1">MRSRRISQFAPLLIALVGLPARGKSQLAHRLARHLNWNGESTKVFDCSEYRRRHMALYGSHDIFRADNAQGSAIRRQSAREAVQDAVLWLKDGNSVAIFDGTNITREQRRELSEYCLSDMGFRILFIECVCEDQELLERNIIEILHYSADYKSMSEEEAVDDLRKKLEHYMRQYEPIDAELETISFVRVENVGETVTAHRVAGQKESGILGYLSGMRGLPQTLYFTRHGESEYNVLGRIGGDASLSPRGLLYAQALADHMNALPCRDHMTVWTSERWRTKQTAAHIRAPKRVVRALNELDAGICEGLTYEEMQERFPQEFAWRDQDKLRYRYPWGESYIDIMTRLRPALSALEDEHNVVVVGHQAVLRCMLGYFLDAKLDELPYMNVPLHTIVKLTSYGYKYKVEMIKLPVDCVDTHRQQPKNCSINRTSADALVTVPSHYDTLPSNLWQNPTEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTH9</accession>
    <name>A0A835GTH9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTH9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="458" mass="53036" checksum="9AD922D42E28B983" modified="2021-09-29" version="1">MTVVEKIQGCITLFIGNFLDNTSRTNNMPRTRSFNNRSHSDSVTMDVLKDFPEDFAKALKTSFELLKNFNVRYMEENYSFIEKYWRFSYIFVTISIHVFSLGFHMPELLTEDEMTQFAYLIPSILVTIHAVLKSIVLIPMTRQISTFISELGSLWRVAFTEKQFKAKDGVLWRLDFVNRASYWASLTGSAQYLLSPLFETLFRRFVLKQDCELLLPFASDFPLDHTNNWLYYLLIYIFQLYSMFLLVSLYTGTALIMISCCALLGAEFLMLKDDLARVKPESCGTISNTDQVDENYNINKDLTIEEFVKKHQKLLELSRQLDNVFNGIVFIDLLFVGITTCAFSFMGQFARGPGYMLISYIGIASSMFTILYLCYYGELLTSASSSIGDTAYENVWYQGSRRYKMAIYFIIKISQKPCCLTSIRYAEVSMKMFTKLHLIIFFLRLGFVRLSLDCVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUU6</accession>
    <name>A0A835GUU6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Carboxypeptidase B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_000088</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="109"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="428"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="15">
        <location>
            <begin position="598"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9424787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="85568" checksum="6E8E84C8E6AE572C" modified="2021-09-29" version="1">MLVAFGFISQIYCSSQYDNHTLIRLHPTSLEHQKSVTQFNDPLGEIEIMKESRGVNDTLDILVPPTRMNFVHEYANSNGLLLEEKQKNYGRILDVPDRHPRRRILNVFDIFSFNSHANMQEYLESTARRYPRLVRLQELGKSFQGRKMRLVKISAKPDANNPIIFIDAGIHGREWVAPAMALYLVHRLTTDPAALQKGGELDGVDWYILPLVNPDGYEYSRSSTSNRMWRKTRSKHSASRCYGVDGNRNYGYKWAVSGVSNDPCHKETYAGPKPFSEPETRMVRNIMMDNAKRMKLYVSLHSYGQYLVYPWGFTGDYLPKQWKKLDNMAKAVSDAVERAGGQPFKVLSAGKWYPAAGGSDDFAFGAAGVPYSYTMELTEGYEFTYPENLLKTILPQFYEGFKEFAGRIRAEFGNQRRKRVTLDECKSLRFCYEEMLHTLLDRDEASCIEDAAIGASTVTIFLKALREFCGDVVLSKERPTTDNPEEQETKPTIIIEAGQQGGTESVGLALYVIEQLVACEENDQMLQNVNWVILPCTNPDGQEYSRYSQIPWKKNLRPSDDQLSYGVDITRNFDVNWGSCTKIESGFSPIYPGVAPESENETIFIKNIIQKHKKWAKMYVSLKRDGHSIHYPYGYKRDPFHPSSLLRRVAGDITMRVNQRTGGVHLFINSSLFVYEGKPHCGHSVDYAFENGIPLSYEMRVFLGSDNKILSKFQPLPRGYDNSLRNGYLSGIREMYNVLTNEKKYGKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXJ2</accession>
    <name>A0A835KXJ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000845">
        <property type="protein sequence ID" value="KAF9404970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXJ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052023">
        <property type="entry name" value="Histidine_kinase_KdpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45569">
        <property type="entry name" value="SENSOR PROTEIN KDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45569:SF1">
        <property type="entry name" value="SENSOR PROTEIN KDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="356" mass="39436" checksum="F32E46C5D0E872F6" modified="2021-09-29" version="1">MLDRQVVLYDEEDVRNPVGAPIKGPLRSLEELAVANWVFVNQKAAGFGTDTLMGAKALYLPVLSNGTTLAVIGIEKDQETPITDEVVTFLELVATQLSLAIEQSKLTSERQQILFENEKERMRGNLLRAISHDLRTPLTGISGSVETILGDQDTVTLPAETKRKLLVGIKEDADWLIRMVENLLSVTRINEETMKVAKSKEAAEEVVASAIQRMRKSYPESQIDVTLPDEFILVPMDSILIEQVLFNLMENAIRHSNSQSAILVSVSFNTKEITFEVADQGKGLTDEQINMLNSGMSKQNSPVDSKTGMGIGLSIVKTIIMAHDGALHVENKPQGGAVFVFTLPLERKEQMEWQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXP3</accession>
    <name>A0A835KXP3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000768">
        <property type="protein sequence ID" value="KAF9405278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17319" checksum="CA366CB6CC7E9983" modified="2021-09-29" version="1">MESKLAASFETMKATLLSRMTAHEEKLEKVTAGNQPPADIAGLQSEYSDFKRFVLDALHSFGTQIELLSQGYDRHEIVMRRKVLLVHGVPEAKQEKLPNVITAVLHDRMKLTEVGRSNIHVCHRLGHSNRGPRPILVRIFTTEHRHLVWHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ08</accession>
    <name>A0A835KZ08_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000463">
        <property type="protein sequence ID" value="KAF9407518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ08"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF3">
        <property type="entry name" value="BEATEN PATH VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="36232" checksum="6C3CE188F051EBB5" modified="2021-09-29" version="1" fragment="single">SGQATDVDVRLVAPAWVARGGSATLRCLHQVPPQLLYKVEFLRTGTKLLQYVRERVPPFTSYAFPGGRVNMTLSTENSITIDNLDPSASGLYWCEVSLETPIFTAASNPRQLTVVYSQKHPPIITFGKPDVVVGGLLRANCTSAPAAPAPRLTWYIDNEKVDEESVKYFSYRVSSSTRTKGGGGYRHRKHQHRLIAPEFNYTAKYWALVSETTVAPTVNTSKHHKCTLKDQQSEEMAKIQERPRVPPAVPISLWVSIAELKAPAHGRLQLTCTATIPDEVVAVNELSLKKPHSETSQANATSSCLQTYPLWILGCGIIFREFTLQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ62</accession>
    <name>A0A835KZ62_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ62"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="371" mass="43366" checksum="241F965058211AE2" modified="2021-09-29" version="1" fragment="single">PSTSQSAAIRDEIHDTLATWESAYFANEEVVHINQGLLYDDDELYGILADNVEDTLENCSQGIETQEAHDLSFCEDFSSDNETEDVTTTREWHYGNAPNTNNLDFTATAGLKAIDMGTLKTFIGLVIHMGTIQYSRMSDYWKTHYLFKNDIFRKYMPRNNIPLTRELLNSRTFCTGTLKMNRKGNPKELLKTKIKKGECIILHDKNNITLAKWMDKREVLFLSSEHNSVLEEVRNRNRNSTSLKPRAIIKYNKYMRNVDKHDQMLSYYTGEHKSVRWYKKVIIHLIEVCLVNSYQLFKSEKKLNISLYDFRANILERLLPPIHPREEIPLAICPMHFPKQITKEPNSRRAKRKQCRQCAKQKTCRHDILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZP3</accession>
    <name>A0A835KZP3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000371">
        <property type="protein sequence ID" value="KAF9408629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="67" mass="7384" checksum="3DF45726D28FF448" modified="2021-09-29" version="1">MRQDNFRNPQTSESTRTSEKRPAAAVTCYTCKKVGHTSNRCPDKNVEAAVKEVNTCGHKASRGSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZU3</accession>
    <name>A0A835KZU3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000639">
        <property type="protein sequence ID" value="KAF9406111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="159"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="400" mass="45501" checksum="B309955EBAAF8EC4" modified="2021-09-29" version="1" fragment="single">GKNGHKWSAQPSEARTSRTQSRNIVHIVQGPKNEAIIVLHTNVKIATKRENYAAKTATVSDTCAEEIYALIGLLLLAARKKDNHLTSAELFDPSESGTKYISISDDKSTCEERKAIDKFAPKREIWEMLIAVCRDSYKPGSYVTVDEQLLGFRGGCPSLYGTNKLLWNSKSASYHNKSLREDAWREISIEMGVPVPELKKKINWATTPRSSNTRASARNIIHFIPGPTSDARDLVEPIPIFHLYLSDEMIDQLVIYTNAEIEIKKVKYKELTHTISPTSAIELKALLGLLMQSAAIKSNHLPTRTERQKTMRRRTFVQSLADKLIEPWLRERYNTVTLRRDIKASIKDILKIEDATPTTSQAQQNKRKICSFCPYKKHRMTKYVCSRWKTAICGEHTIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L056</accession>
    <name>A0A835L056_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_010126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L056"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="106"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="305" mass="35132" checksum="82F75AC32089C77C" modified="2021-09-29" version="1">MDIDMIDLMDLEDLDMLETSRRSNRRRYRSIQDDTADLHGVSQPVVSKSCKMVAHSLAMMSRRFIKMPSSLSRLLGIIVCCCASAQQQTMRKFRSIAYFPTVIGAIDCTHIRVKKINPDGGQWYINRKGFSSINVQVICDADLNRGHSNKMAWQCDSRIFRECRLKQRFEAGAFSGILLGDSGYPCTPYLLTPLLNPTTPQEERYNRSHIRTRNTVERCFGLLKQRFRCLLRGMFGDIETTKKTIVACAVLHNIAIDMRKDLFPGEEDNIEPSIQFEPSETVQQYFPSSVRGNIRRRQFIETHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L060</accession>
    <name>A0A835L060_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000384">
        <property type="protein sequence ID" value="KAF9408422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L060"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11000" checksum="4ED58D5E9D2C0F12" modified="2021-09-29" version="1">MRNLLTILGSEAVTKSALCLRNVHVVVPEAVERGSKVEMKCLYDLEQEVLYSVKWYRGDREFCRYSPRDVPPLKIFRIPGIEVDSPNLFENPFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0C1</accession>
    <name>A0A835L0C1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nostrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000230">
        <property type="protein sequence ID" value="KAF9411271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0C1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11823">
        <property type="entry name" value="SH3_Nostrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035656">
        <property type="entry name" value="Nostrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="70"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="634"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="78042" checksum="57C57B4FE20C78EC" modified="2021-09-29" version="1">MAGTFSAIGRESRESSSSSRPASSSDAAPQPEEAEGNMNRENVSNKIAAGMDRWQNTLEDMINLRSSNNTVFKDYYWAQNGFDELRRYVKQGSDFSKELSSILQERIEAEIYYAKCLAKLGTKLTKACKESVGSCAEAWKHVALEMEKRSEIHRNYSSALSDELVKPMKHVIDNQLKLRKKIEGNVDKTTRSLGEWRTAEAKSKKHSHAAARENEKLQDASLEMSRLSRSSSVGHIPHAHSILSAARAERLPNATSEKDAAKLQVKKRKTEDAVKKTEVEYYNVCVHAERARLEWESSVVKGAGMLESLEEERLAQLKTAADCYLRLTSAVPAQLAEATNILVNPIKNANANTDMRVVRGVRSAQTGASEQLLPDFYCEHTTLAMNRERRKQALLKILQLVKQDIDRERKSKQGLEKLSMAIKQTPTFGNDDSQQNVADKLYHMRSMLTYLEAVRYKITASLNELDNRPPVQHPLAAHIQIIRDKQGLQQSILKVPPWLQADYQNEVNKNLTPNYTALTKSVNGGEERERRDSIMSRASSKLRIEHLSFRRNTDNKSAPVTPVVDIPSPPLQKQTVETPNPPESPLDWSERGAGDGLSNQQDSDFDEFSSQSDSSTDLTDIMKNENGDTVPPTPSLGKCRALYTYEARLNDELNLTPGDIINIHEKQDDGWWSGDLNGIYGIFPSSYVEEITTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0I3</accession>
    <name>A0A835L0I3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000492">
        <property type="protein sequence ID" value="KAF9407240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0I3"/>
    <dbReference type="OrthoDB" id="7458042at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032978688" description="Cuticular protein RR-2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14212" checksum="2CC08A41A7A30CFF" modified="2021-09-29" version="1">MFVKFVALLALMAVANASDQSSFAYSVADPYTGDFKHQIENRVDNNVAGQYSLLESDGTRRTVDYAAGANGFNAVVRKDPALIAAAPAISYAAPAISYAAPAIAAPISYASPYGFAKFGAISYGSPFPYSRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0I9</accession>
    <name>A0A835L0I9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000345">
        <property type="protein sequence ID" value="KAF9409030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0I9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47630" checksum="2BFEE76F1E87695B" modified="2021-09-29" version="1">MTLGKVAVGQNIATIHGNAPGLTPQALVDVWYMELLNINSSILFRYVPSSDIGHSHYDYFTQLMWEESNQVGCGGVKFKERLEDASSKYRIIYRLVCNFAPAGNLKNKSVYSTGAPCSRCPFDGICDPIYTALCSYNSAGNDIVTDKDDNVVPGNSDGLIEHSSQHIEALKERDAIDTATEYSNDSTESRPKSTLDNIIQKATFTTFDYFSHLYDYRRHMITSCTKHNLCKDMIMDDFIELLKKKLNNGSMIKDLLTTTTSSALTTYSDNSFSDIGMAAFVNKVYSKKTPTNKVSASEEYVTNSQPLSSVKPVMVHPELAEAKQNHDSTGHYFFPEEDEDNTQTTESYYDDVNLPVSDLVLEDLKMSTATNDFLDEILESDIIVESTTTLVTLSPDNINLYKSGYGVMKKFLQNIVDKSHTPQNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L165</accession>
    <name>A0A835L165_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000390">
        <property type="protein sequence ID" value="KAF9408334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L165"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="172" mass="19038" checksum="F7CBF247A151CCE1" modified="2021-09-29" version="1">MFQISLEHEILLHPRYFGPQLLDIVKQKLYTEVEGTCTGKYGFVIAVTAIDSIGAGLIQPGQGFVVYPVKYKAIVFRPFKGEVLDAIVTQVNKVGMFAQIGPLSCFISHHSIPADMEFCPNVNPPCYKSKQEDNVIQEEDVIRLKIVGTRVDATGIFAIGTLMDDYLGLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1P6</accession>
    <name>A0A835L1P6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000252">
        <property type="protein sequence ID" value="KAF9410684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1P6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="299" mass="34772" checksum="F541E00B444F7FE8" modified="2021-09-29" version="1">MAIKGISLEDEYKKNTGTTPEDIKKLRDWLNTQPHLPGEYMTDLDLILIFHCCDHSAEVSKQVLDLHYTLRTLFTNFFKDRAVDNKTEDNLHKVLLQPLPTRSRNGDAVFYCRLLDYEPRNFEFAKSLRSVLMILDLWQFEEGTWPGFVLIFDLDGLKLGHLTKLDVQTIQQFLYYLQEAMLVKVKGLHFLNAPSFMDRLMMMIKPFMKKELLEVLTIHQIGAKTLDKFVPMTGLPKEAGGEFKTFNEYEMLARLRANKDFFVQENKKRVVESSDQDKPKTISDIFGSVEGSFKKLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1W4</accession>
    <name>A0A835L1W4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000156">
        <property type="protein sequence ID" value="KAF9413536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1W4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="135"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="378" mass="43491" checksum="1790952D15884F34" modified="2021-09-29" version="1">MPARKRPYIKPRRKKEERAKIRYSTDQPPIKPTCGHNTKAYQCSKLNSNDVLFFNRAFYATNDKIKQDNFNLKYVISTAIIRRRPKIGNKPGRLMALKYFIRKKINRALIPVCKKAFLGILNLKKGRLDGVAKRHYVTGSIAVENRGGDKKMHAYRSRKEAVEKQDVCSTCLQLREEITVEKKGSEKIRLMADGCGGQNKNSILLSALMNWLYMNTQNIKSIEIIFPVTGHSFLPPDRVFALTEKQIRKMETILLPEDYMDVLKEHATVLRLGTDIPIFDFKTQSRNVLKSTQSFHFQITKCKRFIITLHRGAVKIRGEMSYYSDTGVAKTINKRGQSFEKLNPEMLLNGVPVNEAKLIDVRKLLETHFGQIGPRCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L266</accession>
    <name>A0A835L266_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L266"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="60" mass="6954" checksum="80D729F3D1BB5789" modified="2021-09-29" version="1" fragment="single">HCEDNLTVRSWWHRCYVLKHQLRPCRHPLLAVLVTRKACKFSACSSINNDQCSLGIGTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2H5</accession>
    <name>A0A835L2H5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000654">
        <property type="protein sequence ID" value="KAF9405994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2H5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="16963" checksum="27C5AB558E8882D3" modified="2021-09-29" version="1">MVCQDFPTININPASLALGGAVVLGTSIAVPFILKYYANEGNERYGRILDNAEFSADAVLEFAHQMLSGSHGLRGCPLRVACWAAQQEYANPRDIINQIVNNKLLASMVNSSAVEDAMISGRHGRSCSSYGPCPLQEHHVPMLMSNLAILTNTPGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2V5</accession>
    <name>A0A835L2V5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000157">
        <property type="protein sequence ID" value="KAF9413499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2V5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25212" checksum="65FE62405B59B223" modified="2021-09-29" version="1">MALALKLEEKIRGEVVTMLSLNDNRYTLSHLKSQIELVSRALDGHETAMRRKILLFHGIPEKANEKLSETVLEIVVRRMGVDDASIDMFEVCHRLGASQGKTRPVLVRLKDMEHRRVLWDCKTSLKGSGVTLSEFLTRTRHRVFMAARKHFGISSCWSAEGKIIVQVADKSRRKISSMGELDDLIALFPANVEPAIEAGGASPSAPGMAPKDPTKKTRNLRKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L350</accession>
    <name>A0A835L350_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L350"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF40">
        <property type="entry name" value="SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="561"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="738" mass="79455" checksum="E38E734EA282FC28" modified="2021-09-29" version="1">MASLQHDIIYELARNASDANAVTQQSSQKAANGASASGGASGAGSAASNAARASDVKPVECNLCHRKFKNIPALNGHMRLHGGYFKKDSDSKKLDKKESTGPPLQTASVSVRALIEEKIISRRGATVASTPSTGTTTDSVSSRTGFVAPAPPPLSNIRQPASPAATSTHFVSPRAPPVVTVASNAATNICAAQRDSTLIELLKKGNTKAVKRSASDPGQTSPQQDFTFRPELFGVSFNSDDGYFSPALNEDTFQFTTTHDQLEELASLEDYATVAASIRERSPVTFPSNRRLAAVLNSPLPESLADFGACHGGSPVPSPGMGYTANSPGLSYSTGGSPGLSFTAASPSSYSNHAEPSPGMAYPTPPASHDAHSPGNTAPRASSPLSAAFFTATMSSQEEVEEALEEVLPEECRSLDAYALEPSPAPRRIMLNSEDPLLSSSPRDFAHQRPFRRHSRMGSSTISPLQQWQHDSLQVCVEGRDTVPAVFLSPSSVPASPQRRKRRASPAGPFRSRIRRTSSHYIPPPILPPDRDGSGLLIECTAGAGTSQTDVLSQLEEPRPPQINIGRDFQAELPALCNDRIDLHRVPEQLLWDPGINDALDDNEVRMFMELAMCAAMPVGGHTKEFALQTLGETKDSKQCIQFYYFWKKLTKDYKLLYLRSWAMDQQVSSQGSVGQISATQAASCTAPTSSFDTEEFPCKICGKVFNKVKSRSAHMKSHRPLDAEPKRPKLEKPYEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3H5</accession>
    <name>A0A835L3H5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3H5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="410"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55317" checksum="175AE9B536E42980" modified="2021-09-29" version="1">MIKNKFYQYGNQSGRIPAYPNLGKEVYDNMVTNKDIVALVNADTSEQMTYGEMAQSIADIALSLSRMGIGKGDVVCICSEKNFEFLPTVLGVICSGAVFSPTDLTYGSPHRVKIVRPRVVFCSLTAFIQHKPVFDEVGSVEHYILYGDQAQDGAILFKDFLTETVPLEDFEPVPVNGLEDTAIILYTSGTTGLPKGIFLFFSYKAMVLYTSREFFHSYGLMYALACLRSSATLVYNVNGGEVPMLEAVQKYKVRVLQLAPMIVTELIKSVNLDRYDLSSINYIISSSTYLREDAVVAIKKRIPSLVSVLQLYGMSEGGCICNELACTKGYKAGSSGLPGLGFIMKVVDLETRQPLGPNRQGEICIKGPSVMKAYLGNVQPDCKDEEGFLKTGDVGYYDEDGYFFVVAPAEFEDILLQHPAVREVGVVGKPHHVHGEVPVAFIVLQSGATASEAELVEHLNSRVTYKMRLAGGVRFIDRLPRGAGDKLDRRDLMQRLVDEDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3Q0</accession>
    <name>A0A835L3Q0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3Q0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF94">
        <property type="entry name" value="CCP84AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="52920" checksum="73D824DF5758F7EB" modified="2021-09-29" version="1">MLVVLFCAFAAANAGYVAQSAPVAYAAAPAAHVVHAAPVAYAAPVAKVVEEYNAHPQYSFAYDVQDGLTGDSKSQHESRDGDVVQGSYSVVDPDGTKRTVDYTADPHNGFNAVVRKEALGHVAKVVAAAPLLPWSLNSSSVIVLITSFRCFLVVVGGVSYGGGVVDGGSLVGYRGSVVGHRSGYFSDHGSSVVGDWGSYFGDNGGNHLSDVSEGFLAHDGVESVVGVSGVVHGALGTVRVYHGVGALYDVSVAALVLALGVAGETVLHVVREAVLGVRVVLLDGDLGDGGDHLSDWGGVCHGGSVHYVRWSRGVRLVGDVGGGGGVRHGGGWFVVFACMVAAASAGLLPAGHVAYAAGPVAYAAPVAKVIAPVAKVAAEEYDAHPQYSFAYDVQDGLTGDSKSQHESRDGDVVQGSYSVVDPDGTKRTVDYTADPHNGFNAVVRKEALGHVAKVVAPVVAKVAAPVAYHAAPVVAKVAAPVAYHAAPVAYHAAPVYHSAPVAYHAAPVAYSAPVYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L407</accession>
    <name>A0A835L407_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutaredoxin-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L407"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="11">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9416785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="116" mass="12587" checksum="FB63AD59D2B291FD" modified="2021-09-29" version="1">MGSLASKITHSSKMASSQEIQQFIKQAISQDKVVVFSKSYCPYCTMAKEVFSKVKQPIKVYELDERDDGTAIQENLAAITGFRTVPQVFINGNCVGGGTDVKALHASGKLEPMLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4D0</accession>
    <name>A0A835L4D0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4D0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032957616" evidence="3">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="323" mass="37455" checksum="77453CFE0AA2C1AB" modified="2021-09-29" version="1">MSIKTVVVLLFCICFVVIKSEENKTIQMSIDKHGVCTVDSSYDLLEGTQYTVEVCTHKLSLRSFRVNEKRRFIQLSNQVIFYDNATVHPFDIKIQHRVYYYKLNVKRSLRGIWQFKFNITTGPKKTVLCITNITTHAKDQKMNLPSAPKPPTPSNDSSLLLIALTLFGIIVLCQTLYIIYMKRQKFACSCRDISKRPPYPLPPEVYDYVDASGQGVTNNTFNIADERTPIPARKIPQEPTHRSRRERLGFQAPKTVHERTTPKIGRKLPPPPKVPSHKYFGQAHKMANKKITRNVTKKQVHDSRLIWEENWEYEQLSPMQKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4F8</accession>
    <name>A0A835L4F8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000358">
        <property type="protein sequence ID" value="KAF9408831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="96" mass="10801" checksum="C5BF1990061F9B5D" modified="2021-09-29" version="1" fragment="single">ANRSYYPEQKNSADWQALGLNCIQWNQPLAGVNDATALKLKVSHSLVTSMLLLRPYMSIVSSSLCWTKETALPFRTYPAIQADSWKMNIRIMAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4M2</accession>
    <name>A0A835L4M2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000154">
        <property type="protein sequence ID" value="KAF9413586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4M2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="233" mass="26544" checksum="4248ED69FB2B17C0" modified="2021-09-29" version="1">MSEYSDLVKIHESVQESVTRRMNEMEAQIQSAGQAKDTVAKVAEEFRSFRELIFKILGLLRSQINECSRRIDDMETRHRRKALVFQGLVETEKEDCRKLICNVINSKMSLDISESVITVCHRLGVGHKDHHRPILVRFSSLDLKASVWRAKAGLRGSTYSVKEFLTKTRQTLFTKARQHFGMRSCWTQDGIIYVKAGDGSRHRVTSIEALDLLLLKFPRAPGNKSDHKPSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5I4</accession>
    <name>A0A835L5I4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminomethyltransferase</fullName>
            <ecNumber evidence="11">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_006312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5I4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000014">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF16">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="95"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="13">
        <location>
            <begin position="299"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="386" mass="42056" checksum="4E5857DB5FC8AB78" modified="2021-09-29" version="1">MCSIARSRVLLAPKVIAPKQLIPGAVSLRWFSDEAKATKTPLFDLHTKYGGRVVDFAGFLLPVQYSDLSLSESHLFTRKSASIFDVSHMLQTNFLTVFLNDKGGIIDDLIVTKVNAETLYVVSNAGRMKVDKEHMRETSEIFRKKGNDVNVEFWETSQRALIALQGPKAAAVLQNLTDIKLEDLTFMTSKLGKVAGVECRVTRCGYTGEDGVEISIPAANAEHVTEALLQSSDVKLAGLGARDSLRLEAGLCLYGNDIDESVTPVEANLTWLIAKRRRTDDNFPGSSIILRQIKEGVSKRRVGIILQNGPPARKSAVLKDGKTSETIGSVTSGCPAPSLGVNIAMGYVSEALKKAGTELLVNIRGKDIPCVVAKMPFVPSKYYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6K2</accession>
    <name>A0A835L6K2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ligatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF2D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6K2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11610">
        <property type="entry name" value="eIF2D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048247">
        <property type="entry name" value="eIF2D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="5">
        <location>
            <begin position="391"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="496"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="63858" checksum="583477DE28B49A93" modified="2021-09-29" version="1">MFAKPYKLKSNNTLKNSEKKHLAQRIQDEFPSTTDEKVKEIVSVKSTCICMRLVLHSGDLVNVYSVDGIPMVIETSEALIPTVCALWKVPNLVPVLAIHTPVLAKVQGGAPVYLPGVAIPSGGIGFPMFQRGSLIAMCTQENAAACIVGRATMSSADMLLRPAGVCLETLHVFGDLLCKDSKFSKVERPRLGPAGYSPTDITIDLTAHVTQLTIQPPLREEWPSLGRQEAPAPLPVQNEPSVIPDNLKDEVPSTEEENADDTLITDDSQMEEDDIPTDMDGLLQWCLLSFLKLEAKNIELPLKTNLLYRNYLVALCPPDRSLEVKKSSYKKLGKFLEVMQQEGLLEVREIEKGVDAVVAVNVSHPKVRAHAPGARIAPAPVQPATDYVAPQVREMFCVTANVADIFAPLKKGTALTAAEVRTTLTEYVKTRQLNSSQLKGAVVLDAVLAKITGKSEQEAVKWDVLMSSVQGKMTPSTEMRFSDGTVKLTKTKLEPVKMQVASRSGNKKVTLVSNLEQFGFNLAALSHVCQTGVAASCGVTRSPGARADQLMLQGDQTYFVAKLLIEKYGLPKKFVEGADKALKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6W6</accession>
    <name>A0A835L6W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-nucleotidase domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_002632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6W6"/>
    <dbReference type="OrthoDB" id="409330at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9421417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="60808" checksum="7E2664FA8D51A4EC" modified="2021-09-29" version="1">MSSLMSLRSNLTNGIQKWKSCLSHLPKKYPEDLLRRSFSTRELLKEAYCRTKLKFKSKKLPQDVNPRGVFACNELDLSEVKVYGFDYDYTLAHYKPSLEHLLYNLGREILLEKYKYPPEILQLEYKPNFAVRGLHYDIEKGLLLKLDSFLQIQFGAVYRGLTPVSTEEVLKLYRNRIIPIAYVEGDTRAHKPNRAKMVHLADLFSVPEMGLLCNVAEYFIRNHIDYHPEILFLDVKNSVQSCHPIMHKIVAQNVEEYIRPNSDLRKYFQMLQENDKKLFLVTNSPYHFVNAGMEMLVGHDWRDYFDVVIVNANKPKFFTEVSRPIRVFDKNANTHIWEKVSSLEKGIIYYEGTVKQLQDLTGWYGHQVLYFGDHPYSDLADVTLEHGWRTGAIINELTHEINTLNTQSFKENANWLQMLTQLIEDHQDYKDAEALEVVNEWMAERDYLRNEIKAVFNPQFGSVFRTYHNPTYFSRRLFRFADIYTSNITNLMNYSLTHTFYPRRGVMPHEYGSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7C5</accession>
    <name>A0A835L7C5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000053">
        <property type="protein sequence ID" value="KAF9418596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032339587" evidence="1">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="28123" checksum="F3DBD4372FA17647" modified="2021-09-29" version="1">MIKTIAVLLAIVATAYSAEISSSYAALDKHTAFKPELATAPLETHAVQDMPHEAAHPVYRPEEMIQARARIEPVKAFGPVIKHDSMLSDQPEVPTEVNRIDDLGILANGYVPGTADVAYPDVPYAPAYYYDSGYGASNNYDMYNSNNYLMEPDTSAFSLLWSQMPHARTMVSFVGRTITWILNSVIVLILGSLLTVGVCTYTNLCTIAFHGVGPIHEEMRALMSPERLEKISSAADFVKTAIDKYQKIQKVTDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7R7</accession>
    <name>A0A835L7R7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD and tetratricopeptide repeats protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="77079" checksum="C0C987FE7483E14D" modified="2021-09-29" version="1" fragment="single">ILTNNLAKMGRREEPAWASGTVGLLASRERGEVDRKFQSRLTVTRPMIDRLGLEKELHGHMGCVNCLEWNHDGSILASASDDLHVMLWDPFRYKELMNIATGHTGNIFSVKFLSPDVIATCAADGTVRARSVNSNAPLLECVCHCARVKRLATAPDNPHLLWSAGEDGLVLQHDLRMSHSCNPDSANVLVNLLNHLGRYAEAKCVAVNPRRPYQLAVGANDFYVRLYDTRMIKLARLQISDFYVHSYHPAYISNRSKCKCMSGQTSGPSRQMWERQNMRCSRAGHGDPDNNIPRAAVHYFAPGHLSMEPNEHTFPKKATTYVAFSNDGNELLVNLGSEQIYIFDINSARRPVLVESFIIQHNHGNRTSDAKQPLRNGTNGTTPPPQPPPPQLPDRVRQLKEMANDFVNKGNYPTAVEFYNEAIALCPDCAILYSNRAAALMRRGWSGDTYAAIKDCYKAIKLDASHVKSHFRLAKGLMDLKRAREAHECLLYFKDKFPRHATSHAVFLLQKDINVALESMETTPDEAAAESEDSQPTSLLERQLRGAALDYSQRLLGHCNTTTDIKEANFLGPDANYIAAGSDDGSLFIWCRKSGNIIRCLRGDDSILNCIQLHPSMFLLATSGIETVVRLWSPRPEDGKEESRIIRDSGSAAQANQQRMRSDPFEAMLLNISFASGNVDRDLHSPACRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L896</accession>
    <name>A0A835L896_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Required for correct subcellular localization of pgl-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L896"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="545" mass="58946" checksum="BE79C65B3EC9988D" modified="2021-09-29" version="1">MALHVPKAPGVPQMLKEGARMFSGLEEAVYRNINACKQFAQSVRSAYGPNGMNKMIINHIDKQFVTSDAGTIIRELDVEHPAAKLMVLASQMQDSEVGDGTNFVIVFSGALLEAAEELLRLGVTPSEIADGYEKALEKCLEILPGLVCEEIKDCKNIDAVTKGITPSIMSKQYGYEDFIASLVAKACIAILPEKTTFNVDNVRICKILGSGLLQSEVLSGMVFKREVEGDVSSATNAKVAVYSCPVDITQTETKGTVLIKSADELLNFSRGEESQLEKQIKDIADAGVKVVVAGAKFGDMALHFLNKYGVMAVRLNSKFDIRRLAKTVNATVLPRLTTPTAEELGYCDSIGVEELGDTRVVCFRMESSESRISTVVIRGSTDNYMDDIERAIDDGVNTFKGIARDGKFLPGAGATEIELAEQLLQYADTLPGLEQYAVRKFAVALESIPRALADNSGANATEVVNNIYKAHKEGNKNAGYDIESENNGVCDAKEKNILDLYVLKYWGLKYAVGAAATILKVDQIIMAKRAGGPKPKAPAGSDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9L2</accession>
    <name>A0A835L9L2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9L2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16460" checksum="2BF6772C4F5F7146" modified="2021-09-29" version="1">MLFWLLIKNVAALSDREKSAIQKELTSVGLQCIQQHPLSLSDIRSFRNKIIPDGKKPKCFVACLFKKIGVMDDMGMISPMKAQENAKKVFKDNEEHIKNVNEIMEKCSSVNQQNTSDGNKGCDRAKLAFNCFTENADKYGFNFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9X4</accession>
    <name>A0A835L9X4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033059964" evidence="2">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="471" mass="50216" checksum="6C8E6CCB87C85B88" modified="2021-09-29" version="1">MKVLLLCLAFAAVTLAMPVAEEKPDVAAQAPAVAAKPEEVNDQPAPVEEKKVEEVPKPKEAEKEPEAKNVPIEEKKSDKDESEKAAEPPVKEVVPESKSTEPEAEKKPESSDSNESKSEEKVVEPEPKSVEEPKPVEESKPAEEPKAEEVPAIVNEVPKDASAKAAALPEENIDVVTAVKNDAGIADDVMMPDVLIPTPVKKIDLPQQPATVAEPEPKKSEQPAPVEEPAKAEVSKPEEPKEESKAAESASDAKPAAPKQEESSEDSLRVVRNTVDGKLVVAAEDKPEAVAESKPEAVAESKPEPVAESKAAPVEEKKPEAVEEKKPEPAVENKPEPVVESKPEPTVESKSAPVPENKPIEEAKPEAKPAEAAKEADVPKEVKKDETEQKESKSADIAAPEPAAKAESAPAPAVEEKKSDNKETVPEKKEPAPAKVEEQPLNDKPSSSSEESASEESKENSSEEKTGAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBA4</accession>
    <name>A0A835LBA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syndecan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001050">
        <property type="entry name" value="Syndecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030479">
        <property type="entry name" value="Syndecan_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915:SF1">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00964">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Neurexin/syndecan/glycophorin C" evidence="12">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="287" mass="30758" checksum="08DF0751678E1AEF" modified="2021-09-29" version="1">MLFLWLVEDDYSDAAVEKPTEETVVQIQNDVHSPPDHDLFIDAADDGSGLDTDESSGSGWGAGPGPDDEDGRGSGDEPNGPPDDEDYGSTTIGSEETERTIIETPITPDNSEPDDIDIPEQTEPPVVTKVNIPLQLPTDPRNIDVLIPNTRNKPGEGTSEEGRGAGEEQPSRPDQTDISISGEDLVPSVDQEPSGSNVNQESRAPDKVVIMNAKPEDRATSFFAQPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPAAASYGKGHNNREFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBP0</accession>
    <name>A0A835LBP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="3"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9423849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="496" mass="55313" checksum="FA301ACE78DB90C2" modified="2021-09-29" version="1">MHEPQQLKPWLGVWDATRPLPGCLQYDPFVKKITGSENCLYVNVYTPKMNPGANLPVLVFIHGGAFMYGEGAIYDPIHLMDWDMVVVTLNYRLGPLGFLSTGDEVAPGNMGLKDQSYALHWIKNNILMFGGNPDSITLTGCSAGGASVHYHYLSPLSRGTFNRGIAFSGSALTEWTHSIKPAEKAKALSSIVGCPTNNNKEMMDCLKYRPAEAIVNAQIDMFEWKVHMFTPFSPVVEPRGVREPFLQQYPYHATRSGQMMNVPLITSVTSEEGLYPGAAYQETPDLLADLEAHWNQLAANIFEYNDTLPLNQRDEVARKIKQHYLGGKPVSQETYPQLIQALSDRLFVADVGKTAQLHAAKSGQPTYVYRYAFRGTSSLSNLMAHNDKNYGVSHGDDVLSIFSFPGMTQSEHDTAMIEALINMIYSYSTTGTPKLINGGPVWEPVKPGSPELNYLDILSPTKMEMKSSSDFGQKAFWDSLGFNENENYREYLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC20</accession>
    <name>A0A835LC20_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="352" mass="40313" checksum="ABF95C78A32025CF" modified="2021-09-29" version="1">MEFLLVLTVCVPFVISFFPGLMLGPGRWLVLNVMTCDNPEQYDLLFDISRKKINRTHDCFDIHINLDRVIDNTYAVGIKVDGGFKYYQTIADESACKFLMRQAEANVKGYSLRGTSIPRSGLIEIKNYVFDYRELPKTGVYGTFEAHAYIVYKGIRMGCTKVQSYVKTYLNNMSVALYFAFAFTVLFSTSYGDVELLGKGRWLVLTMMNCEDADQYDIILTSSRTKINRTHDSFNLHMDLDRELNSSYGVELVIYKEMDGGFKFHQTMGSDNFCDFVKEYTGENWSKLLSMAGVDPPDCPIPTGEFKITEFVVDYQQLEETGLYGTFDVTVFLLHEAHRIICTRWLGIGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG03</accession>
    <name>A0A835LG03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="22558" checksum="72BAFB584180D8E0" modified="2021-09-29" version="1">MLRSFIRSMCTMTIKNKPPIPVYGLEGRYVSALYSAASQKNELDAVEKSLRDVQQVLARPAIVDFISTSLVSRPVKAKLLMDIGKETGMPQTAINFLGVVAENGRLKNLRRMINMFLNIMVAHRNETPCEVLTAEPLDSATKTELIAILQKFVKPGKVIRIRERIAEDCLGGVVIGFEDHHIDLCIARSFNKYRELLKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0K1</accession>
    <name>A0A835G0K1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000805">
        <property type="protein sequence ID" value="KAF9405134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0K1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="2">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59716" checksum="3789C4DA75EBB581" modified="2021-09-29" version="1">MALSPAMNLNIPTDQIIGFEDFGKDVNSNQTENIADHVLVLMIKGIKMHYKQPIFYGFCKSATKAVILKNIIKNVIKKIFEAGLTVVATVCDQSTINSKVVHEMCNKLTEAHVLPEKIPKMKVKHAAQVFSQRVSGALRFCARKHLLPQECTDTADLLLLFDQLFDSFNGGSYKITHKIYKTCVKNNSEHFTLWNKILPVLCSMAFKTEAKKRDGTMTVSYEKVPSIKNWIHNIRTVKDFWQYLTKEYNITSLLMRNLNQEYPVENFFSSVRSHGVRNINPTCLQFENIYKTLLVNNLCSNHSLGANCEEDTNKMLHNLDVLLMNNPPEPPRNNDDDKIEEICSNDILAGGSDNELVSETKKYVAGYVIKKTKTLICKSCNTCNLDLYDTTPPKVDNYILSIDITRKSLQYPSQNFTICVNNIIKIIKHFLKNCPHKSGIIRKIKILVRNIVQFDFLSCDIHKEKIEIFVTNFLIKCIIYSWCNNVNRILKGKHVRHVDDKVKIQALKYYKTHTKHKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0L2</accession>
    <name>A0A835G0L2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000766">
        <property type="protein sequence ID" value="KAF9405290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0L2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="208" mass="23377" checksum="D91ADD34C525A4B3" modified="2021-09-29" version="1">MIRRSFVCSSIKKEIKDHLYTTPIDSHLFGSQLGDVLKAAKAIHKTSAEMKTGAPIPGPPRRFTNQPQNLNTRRLVPSHGRQTGAAARHSTMPAQNGRQNYQRQQRRASYVSSKNNEIADAESRAAHPDIWELSNNAFNNIVKTFDEAMGIAVLPYWPIQPWFPLFESLLVSMIILFEPSDEALLTSSHRPPPLRLTLAAGRLSGRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1E5</accession>
    <name>A0A835G1E5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000670">
        <property type="protein sequence ID" value="KAF9405852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1E5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18623">
        <property type="entry name" value="GH32_ScrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="360"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="480" mass="55127" checksum="BC9277008A09B848" modified="2021-09-29" version="1">MNTLSGNDPFTENRSVSADKVNDRFVPRYHVYPPHGWMNDPNGFCKYGDNYHLFYQYNPVTSLEPGIAHWGHVVSPDLIHWKHLPIAMYPDQPYDKTGVFSGSAIIENGTMYLLYTGNVNHPGETPDHTQRQALATSTDGVNVTKYAGNPIIMGEEHQPNIRDPKVWKHGDTFYMVLGNSFNNDSLGRVLLYSSPDLITWKQISILDESDGPLGYMWECPDFFELDGKYVLLFSPQGVKPQGDKYRNLYQTGYIVGKFDYESNLFTPLTEFRELDHGHDFYATQTILDEFRRRIVIAWCDMWEQDYPERKDGFTGQMTVPRVLELSQNYRLIQKPIKEIFLARGRKLHNGKADGGFTAKLENKAADIRVKAHRLKDFTLFIESDNASVSISYDHKKGKVTLDRGGEDGVRSTKWRPDRQLQWQILVDASSIEVFCGEGEVTFSSRYFPYSDVTVRLGDDTAAEDLTIFEMRRTVEEPPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3G2</accession>
    <name>A0A835G3G2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000641">
        <property type="protein sequence ID" value="KAF9406085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3G2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="43343" checksum="45E45BEDDF6634B0" modified="2021-09-29" version="1">MQGSLSFGKEVVDTLSHYMRRNAGNVVARRRSIPFSKETDVIYIIIKSAYLCRDLDFCEGKLEQFLNEYIMVQTKSIEAIFEGIVNQNQLLDQDAKTEQRLVFEEDLKKCLREIRRVLRQANMKMRDESITYLWIEVIKKISVMFQTAAILFAAERLEGRSDEIMEVKKKLTQKLVIATTIVEGKYESKLCSEYDICIKAYEVTKALNTLLGALRDMEEENVKIFIRYVSEALLETNLYSHLSEVTSNELQIILNDMAYSENVSAKTVLLSIQKAVEDRLNALHLKTHMVNGRDVELVHVILSDMDHVYGKSSIDPFHVFMSSFFTWERTKSRLSGPIRSLLKELTNEINGLPDDLGFKLINEVRAFLEITVDPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G637</accession>
    <name>A0A835G637_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000440">
        <property type="protein sequence ID" value="KAF9407753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G637"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="203" mass="22469" checksum="787DD36F577F967D" modified="2021-09-29" version="1">MDFGSNNITYRNKPSRTSSLTDLSDVINSSEKTILDTTMMSIPDSFHDTSEENRELINEIKILKQQLLSAHQEIDNLNIENLRLKTDLQNMISTANAYKKICSTPEKKGTATPRLSKRPRQVNSPHEVNTRRASLIPNNATCKQNKGTQTENSTSQTVLKSRGSSASVPPTSPVITKTVISNSKTKNKLCILSSNKHNSSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G766</accession>
    <name>A0A835G766_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000412">
        <property type="protein sequence ID" value="KAF9408034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G766"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase D-like" evidence="7">
        <location>
            <begin position="93"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="294" mass="33624" checksum="289DC92A717367C4" modified="2021-09-29" version="1">MDWKNAKLLFLSTATVIVATQIVKKAYKYFFHPRNVQSENPSDDMCDDLLNLKTRDINDVIVFSDDATRHTVRIPPTKEITICESRDLNCYKLLRYINSTRETLDVCMYLITSGEIAEQIIRLGQRHVLVRIVVDSDMAFTPPSQIKKLKEYSFIQVQTTSKSRKTFLMHHKFCIVDGPKAIHRKNMLKAHAEKLNVHAKDIKNPVKIPAKVNVTGFVMSGSLNWSSHAMISNHESVIVTSHPKIVTKFENEFGSLWVENEPVGIENVVINLHAFYTAQVKCYLTATFNNFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G767</accession>
    <name>A0A835G767_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000446">
        <property type="protein sequence ID" value="KAF9407681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G767"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="304"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="49265" checksum="7C122EF2828DB34A" modified="2021-09-29" version="1" fragment="single">PACGEYEVYTECMNPCVNDSCAAMGSLKPNCTRPETCEPGCLRGTPLVPVIYKPTQAPHVTTRGAGNMWRCAVLLSVCYVGLAARQGLLGAFNPFEFHMDCGPNEEFNQCTHSCPPEQTCDTRKIHTLCLAVVTPCIPKCVCKQGYYRKTEGGECIPEEECGKSSVYKNIVQLVAKVKSTRSASTLAWMTLALQWGVLNRTVPALSLVFRAVFARRIILRKMNTTHVGLNVIVKNYEILPIVDRLRGIPLEQVIYKQTQAPHVTTRGAGDMWRCAVLLSVCCVGLAAGEELLDDFDPFAVHMDCGPNEEFHQCKHSCPPEQTCETRKIHILCAAVWTPCIRKCVCKQGYYRKTEGGECIPEEECGPACGEGEEYTECVNPCVDDTCAAMGSLKPNCTSPEPCVPGCICKKYHFKQNKYYPCWPKCYCEELRDSPDCRPVYDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7F8</accession>
    <name>A0A835G7F8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="531" mass="59104" checksum="8D3263BA30C4017B" modified="2021-09-29" version="1">MATIKSDKDIQEVSCPICNKMYQKTMIEEHANKCLFLNSSEDSKLKQNKVDQVTCKRNNSHLNNLSIQEKRPRISTSPSTSKTEKSPLAESSKKTQLKESKSIPLAERMRPLYLEEIIGQVQVFGPGSMLRSSIENKIIPNMILWGPPGCGKTSLANVIANICKEQNNLRFVKLSATMAGINDVKEVVKIAKNEAQFKRQTVLFMDEIHRFNKLQQDTFLPHVENGTIILIGATTENPSFSLNNALLSRCRVVVMEKLSADDVLKILKHALKKTGKAIIGNGKLDLEKTASADLPWCIVEEASLKWLAEICDGDARVALGALELALAARAPETARSEPAILRFEDIVDGIKRSHMVYDRKGEEHYNTVSAIHKSIRASDDNAALYWTTRALHGGEDPLYIARRLVRAACEDIGLADQSAIVEAMACLQGCQQLGMPECDVLLAQCAVRLARAPKSTEVYRAMKRCRKSLMEAKGPLPPVPLHLRNAPTKLMKELGYARGYNMLHKDKSGLNYMPEGMEGKNFFQDSDDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7Q5</accession>
    <name>A0A835G7Q5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000339">
        <property type="protein sequence ID" value="KAF9409106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7Q5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF2">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="9161" checksum="1D7A4FA1E5F55686" modified="2021-09-29" version="1">MTIAVQQELGSNYLWSMDELFPVFHFVVVRARILQLGSEIHFIEDFLEPAMQHGELGMLLPNTPGENVNELTMRSGRGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G816</accession>
    <name>A0A835G816_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G816"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="30099" checksum="BFEEF8099ED20BE0" modified="2021-09-29" version="1">MLGGPEWGQRESSPPRDAPLPSFGFTQEQVACVCEVLQQAGNIERLGRFLWSLPACERLHAHESVLKAKAMVAFHRGNFKELYRLLESHTFSPHNHPKLQSLWLKGEIYWSHTIWKRRGYEARPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRSVLRDWYLHNPYPSPREKRELAETTGLTTVQVSNWFKNRRQRDRQAEHKDSGGAGDKQLDSSTDDDSDAPAHGPAPHALPAHAPQPLYPLYEHPLAHLQYHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8I5</accession>
    <name>A0A835G8I5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8I5"/>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="118" mass="13938" checksum="7D33033E411337D8" modified="2021-09-29" version="1">MILDDLEEFFDMAPTKRGRRGVSDADDEDDEYRRKRDRNNEAVKKSRFKSKQRTQETFTRVNKLKAENQMLEEKVKTLTKELQFLKELFLAHASNTPNAKFDGIDLDKLLEDIPDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8X4</accession>
    <name>A0A835G8X4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA-capping enzyme</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA 5'-triphosphate monophosphatase</fullName>
                <ecNumber evidence="12">3.6.1.74</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">mRNA 5'-phosphatase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">mRNA guanylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.50</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP--RNA guanylyltransferase</fullName>
                <shortName evidence="12">GTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_011430</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="12"/>
    <dbReference type="EC" id="2.7.7.50" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000339">
        <property type="protein sequence ID" value="KAF9409104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17664">
        <property type="entry name" value="Mce1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000111">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017074">
        <property type="entry name" value="mRNA_cap_enz_bifunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036958">
        <property type="entry name" value="mRNA_capping_HCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="2 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="18">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="13">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="14">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="463"/>
            <end position="465"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="533"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036958-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9409104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="557" mass="64766" checksum="8C0B88569A8F3301" modified="2021-09-29" version="1">MAQRDPGPIPNRWLRCPRKATGLIADKFMAFKTPLGSQFNDKVPEENRFTPSMLFMMKSMKIKLGLWIDLTNTSRFYDKKEVEETGCKYVKMQCRGHGETPSPDQTREFIQLVSRFVSQKPLELIGVHCTHGFNRTGFLLVSYMVEHLDCSVQAAINEFARMRPPGIYKQDYLQELFRRYDEVELTPPAPMLPDWCHEEEEEVDDDVPSHSQNSSSSTPRKHKGKGRKETTHKKASFMPGVRGVEPFDSQPRLGEVQRKAQRFCEWDTTGFPGSQPVSMDTANLRKLHEKPYRVSWKADGVRYMMLIDGEGEVYMLDRDNCVFKVHGLQFLYRKDLRRHLRNTLLDGEMVIDKVDNKDIPRYLCYDIISFEGVDTGKMEFYPTRLNYIENEIVYPRSQAIKEGIIKKEREPFSVRLKQFWELTMTRQLLGEKFAKSLSHEPDGLIFQPSKERYIPGPCEDVLKWKPSNMNSVDFRLKIVTETGQGLLPTKIGYLYVGKMDQPFASMKVTKDIKHLDNKIIECTFEQGRWVFMRERTDKSYPNSYNTATSVCLKDPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Z7</accession>
    <name>A0A835G8Z7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Z7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="64" mass="6919" checksum="F529F916AAACC676" modified="2021-09-29" version="1" fragment="single">MVPVEEPRCGGVAARSQVTTFAHELSEARPRRGTAAVARAPRNGTKPPPRRHTRHPANQASPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G904</accession>
    <name>A0A835G904_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000345">
        <property type="protein sequence ID" value="KAF9409036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G904"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="265"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9409036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="551" mass="62831" checksum="32644720A57BC720" modified="2021-09-29" version="1">MASGGFRLRFGENHSVQEDRNITTESPSRRTTRIRAKPKKYGDFLDDSPVKRRTYKDISSSEEDSEITDEAALPKPTALFTEDDVEGQDMFKFKSRHTKQDLQNRVKTAIYSPKTVDSPMKTPKKLQSFIKVAQETPKQVKEIMRKRICNEVDSDSADSDFSGSSSDFVPDASDHDETDSSSSEDASSDEVEQPKKVVGKAVKGRDNKAKVKDSEYYVTPDNYFIMHSSKKIATSDHTLARLKNLNIDENNVDDIQISAEHKEIIKELNHSYTQLFNKWLYVLSENFNIILYGVGSKRSVLQQFQKQKLKDFPCIVVNGFFPSLTIKSILETIVIDLLENTNVPSNIGDVVNLIDTQLKENGVNLFLIIHNIDGTMLRNAKAQSTLASISQIRNVHTIATIDHINAPLLWDHTKLSKFKFTWWDVTTFVPYSEETSYENSLMSHRSVALQLSSLKSVYQSLTTNAKGIFKIIIEYQLENQKQNYQGLPFKDLYSKCREQFLVSSDLALRAQLTEFLDHKLIKMKRTYDGSENLVIPIDVTLLQQFLDQQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G971</accession>
    <name>A0A835G971_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G971"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="192" mass="21920" checksum="AEC926930484DEDD" modified="2021-09-29" version="1" fragment="single">GPVKYAAFGILKRSDPPKYWQIHNVKRVIPHPEYHPPHKYHDIALIETEDLIYFDKYYVRPACLDVKSKPDFYAEATGWGALGHNQDLADTLQTVTLRKFDAKTCSLLYPKHRHLRNGFDEDTQLCYGAEDDPKDTCQGDSGGPLQVRNGHQCSYSILGVTSYGRQCGKTAGSGVYTRVYHYLLWIENIVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9D3</accession>
    <name>A0A835G9D3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000240">
        <property type="protein sequence ID" value="KAF9410936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9D3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="454" mass="48614" checksum="0762C73DAAD8283D" modified="2021-09-29" version="1">MFINNEWVDAVSKKTFPTINPQDETVIAQVAEADKADVDLAVAAAKKAFERYSPWRLMDASRRGLLMLKLAELIESQARYLAELETLDCGKPVKDAEDEVYYAASVLRYYAGKADKILGNTIPADGEVMSFTLKEPVGVCGQIIPWNYPIPMISWKIAPALAAGCTIVLKPAEQTPLTALAVAALIKEAGFPPGVVNVLPGYGPTAGAALTHHPDVDKIAFTGSTEVGRIILGAASAVNLKRITLELGGKSPLVVFNDADVEKAAQIAHAAAFANAGQCCCAGTRTYVQSGIYDQFVKKAAEIASKRSVGNPFDNVQQGPQIDQDMYTKVLSYITAGKEGGAKCVAGGDKLGDKGYYIKPTVFADVTDNMKIAREEIFGPVQSILKFDTFEEVIDRANDTNYGLGAGVITNDITTALSFAKQVRAGSIWVNTYDHTPSQTPFGGFKDSGLGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I1</accession>
    <name>A0A835G9I1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000260">
        <property type="protein sequence ID" value="KAF9410509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032673172" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="26727" checksum="E8A1D75198F22BB5" modified="2021-09-29" version="1">MCGEMGKAVLRALTGALLCGLVSDAAYLQQYDPYETHYEQAIIRPKPLREHEKPQDLRNVPGTPGVDFPIYHSVPDTSFSCDHVPVRPGMMHRRRARIYGITFRLDDAKSNDRWDGVEIEALNPMDNSSTDLLRGPLLVYGTLAYHVCHDGREGQQGASFLCTNGTLFDQAKFACDWWYNVDCSKAITFYKLNADPYHNPFIPKPKPEEHEEVPAHELRPSHGLRPSHGIYYRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I5</accession>
    <name>A0A835G9I5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPR180/TMEM145 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF43">
        <property type="entry name" value="INTIMAL THICKNESS RELATED RECEPTOR IRP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="2">
        <location>
            <begin position="182"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="451" mass="51913" checksum="965CA02B4846E35F" modified="2021-09-29" version="1">MCFKIGTIIFCTFFIFVTSTHIKGEFSTNDFFKFLVKFGFQKTDIHYQKETYGYIFGNITADVPFKYPITFAVLDRSHFLHYYKSRDIIDKELACQVMFQNLNGTAYHPKCNAYGQDLFRRIPCPKGGLCVDEDTPWNVIKKNQFTYVIQNSGQPRFWYVSMVSCYLDEVTCTWHHYTGAPSTQKHPVTKLFTFSLVLEFIALCFNVLHTVKFAVDGVGFAGLAAAGDILDIMSRTLFMLLLLLLAKGWAVTRLELTYKPLVFGVWLAYGIVHILLYVWNTTEVDIIEEIDEYQTWPGWLILALRVAIMTWFVLELRYTMMYEHNMPKLNFLLHFGASSLVWFVYLPIIALIALQISPLWRFKFLLGITYSADCLAFCVMAHLLWPTRSEQYLLLAPSDYTAGIEELDEFNESPHVVHSDTVALTTAECINADDEEIIFTRAAHKNGTAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9X1</accession>
    <name>A0A835G9X1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCMBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000235">
        <property type="protein sequence ID" value="KAF9411081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9X1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="527" mass="60656" checksum="F60B5F72D0BF7955" modified="2021-09-29" version="1">MHDLMTDFETVTPDLWMANEEAWKEKLLKLPNWFQIPLINSNASHNLPDGTLVRFRGMVQDMHNPEFYFEQFEVFNTVTNVTKSKSGKYRDTAHILENEKINYTENLRSSQRQTMVVVSMPGLNDWAQQLEDKQNHLKHLEQQPNTSKRLSNSGTKLKRSHDETEEDSDAMEVVDETVTNKEPKTSDTVNNTGSVLSREHLLNFPLPDMPSKSCIVKIYDDKSVLKEANAAREHLLKALTELLLGDKLAADYLICHLISCIYLRQETLSLGQFCLNLSNLPIQKYPNYAKQLYDIIKQFVTKSYYLPLTIENMNTLSLLPKKDYECNRLTSGVLQLSKDTHLVLDETKMEQGRLDATGVNNVAALGNMIMTQKVEYDFKYYKMDFESDVSVLILSEGKSLLPSDYHLPLRPEEASLKIFDAIVEAATYYLKEDIMNVIRKYLTSLKLVKYTISEDLQFVEDDFIEMRSNSDSNNPVTADDLHRLLVLARLVSLSRGLDTLNKECWDITKNMEAERLQRIKNRVAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA55</accession>
    <name>A0A835GA55_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA55"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052865">
        <property type="entry name" value="Zinc_finger_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47241:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47241">
        <property type="entry name" value="FINGER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="267" mass="30405" checksum="A00A0B99EA36C7C5" modified="2021-09-29" version="1">MFFEQLDNDSRKVKCNQCQVIISRGGQGKTANTTSMNNHIKYKHPTLIPQLGSAIKCSSTDDSTKSQISAEELPKAVPTPATSVSSQILGKIIELLKPFEEITKIISSSCSSVSEVIPHLKTLQKYLEMYYDESKEIMEIKALLENDLNIRFDMDHNKIFTLATLLDPRYKQQFFEAEDLITIRSQFLLESLKNSMSDDDSDSGKDDLQSTSTDENNIETATHRNFWQCYPYFASRKIQEFQDDTSSAAHEQSYCALPLKKRNDDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAA8</accession>
    <name>A0A835GAA8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_008910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000182">
        <property type="protein sequence ID" value="KAF9412641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAA8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="238" mass="25928" checksum="D47CFF1D49B65CC6" modified="2021-09-29" version="1">MNLVRAIPDTMGRFSGKKCRLLSMLWLTGSFFFVELIVGYITNSMALVADSFHMLSDVAALVIAFLSVKMSPKKWSKNTFGWARAEVLGALVNAVFLVALCFSITVEAVKRFIEIEMIHDARLLVAVGTLGLLLNIVGLFLFHDHGGGHGHSHGGVPPPANVRHLTEIVNSNADMALGHNATDTEETDEMVPPKPDKVPNNKKQTPCRAAHDPGHMNMKGVFLHILSDALGECSYVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAQ0</accession>
    <name>A0A835GAQ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAQ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="28101" checksum="CE8C9572BF7B93AB" modified="2021-09-29" version="1">MFPGTSAFGSQAPLHATNFTNQHQALTMPHGHALTYFPPFHIGPHPDFQSSVELTPLSSFSETPPSASSSSFSTPETREEEQPKVVVPNIEEELGFLAEQRANTASSVAPSSQQQNINSTSQDATSKIMDKKFNVPVTGPGSGFMASYLKFLQGERDTSPPPAGRGARKSTWSRTNTNNATNNKPYTPNDHNKSQCDTNVSQQSANGAMASTNVINTGMSLSNPVMSSSASMNATGLLGANQLHGASSLLNSQTKELEDPDITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAT5</accession>
    <name>A0A835GAT5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032523483" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="141" mass="15564" checksum="9D6A8FAD7EF8AA31" modified="2021-09-29" version="1">MKTFAVVLLVAIAAGVYSNEEQGANMLNYVEQSMEKSDQLASRSSYGWGVVGDDDRLISSTYHEAYDLPYLINEQEVTYRGNEYTNISSIRVSSNYGNTTQVVLLDGGLNENYVTLGLRSPRSGGFGCRIDIFATVNCHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBA9</accession>
    <name>A0A835GBA9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MOB kinase activator-like 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_012729</name>
        <name evidence="2" type="ORF">HW555_010118</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000107">
        <property type="protein sequence ID" value="KAH9643854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBA9"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9643854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25542" checksum="C0CB9EBDADC2059E" modified="2021-09-29" version="1">MAVESVQILRRNRPGSKAKDFCRWPDEPFEEMDSTLAVQQFIQQTIRRDPSNLEAILKMPEAQDEGVWKYEHLRQFCMELNGLAVKLQAECKPETCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSVKESSVAKLGSVCRRVYRIFSHAYFHHRAIFDAFEKETHLCKRFTYFVTKYLIIAKDILILPKLDDETPVGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBU5</accession>
    <name>A0A835GBU5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_009728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000223">
        <property type="protein sequence ID" value="KAF9411487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000132">
        <property type="entry name" value="OSMotic avoidance abnormal family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000185">
        <property type="entry name" value="OSMotic avoidance abnormal family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="487"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1309"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1370"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1309"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1323"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1370"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9411487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1394" mass="150645" checksum="F13EC88599D6BE5F" modified="2021-09-29" version="1">MVYLRTVRADNMYNFQDVKKLSRISSSSHESQPQLYTQERFHAKGFNIEIVRGLLLETYAKGGMMAAEKLIRDEFAAYMYAGGRGRVINRAEYLRWKFRDQEQVVLPIEASLSPHDPLAKWEDHTACWQMCYRGALGESLLHVLIICDTKIHTRLARTLVKCFPRLSLDVVEGEEYLGASSLHLAIAYSNNELVQDLVEAGADVNQRAIGSFFLPRDQQRVPPARQTNYEGLAYLGEYPLAWAACCANEGVYNLLCDSGADPDAQDSFGNMILHMVVVCDKLDMFGYALRHPKVPASNGRMNLAGFTPLTLACQLGRASVFREMLELSAKEFWRYSNITCSAYPLNALDTLLPDGRTNWNSALFIILNGTKQEHLNMLDGGIIQRLLEEKWKTFARNKFLKRLLILMLHLLLLSLSVYLRHSSAEADAHPDWGLEIADARSGIRLASELGTIASTLCYIILQQGDELKNQGVVAYFKQLIHEPAKFIFLISNLLLLACIPARLMRQTMLEEALLIFLLPGFWFLLMFFAGAVKLTGPFVTMIYSMITGDMFTFGIIYSIVLFGFSQSFYFLYKGFPNVQSTLFSSYPSTWMALFQITLGDYSYTDLSMTTYPNLSKTVFAIFMVFVPILLLNMLIAMMGNTYAHVIEQSEKEWVKQWAKIVVSLERSVAQEDAHKYLQEYSIGLGPSDDPRYEVRAVMVIKSAAKTRAKQRKGALTNWKRVGKVTIAELRRRGISGEELRRLMWGRVSISTPTKAPLGRRAAAPPPDVTSAGVPLAPGAGAEGGGVAPALSSALNVMAFTQEMNLGTAGTPGQDHKQPTPDLLVNGKTASVPISTISSQPFVATPNQLSVPSSFPQNKSSLEAPMTGAIPVASTTAQMGSMGIQMGYTGVQTPLPGAHIPVSGAQTPLVGAQMAYTGATTQPSGTMPYASTMPLTGAQMPLPGGQAPMGSGQMVMGSGQLPMGSGQIPMGSGQMTMGSGQFPVASGQMTMGSGQMPMGSGQFPMGSGQMTTGSGQMTMGSGQMPMGSGQFPMGSGQMTTGSGQMTTGSGQMTMGSGQMPMGSGQMPMGISQMQVPGGQMAVTMQGPAYGAMGQMYPIQMYGPGMPQMIEIQVQKPVSDEVFPDYLFELIKLAEDPASDKSKIKALAEKAADLDAVPEIDINVSTAARSARRVVAGAVSGLFGVAADAPTADTGWRRERNENSDSDPISESVLLGRASRARRARSASRRAAPPPPHLYVPARSMYLVASESSAVESDVPLEETPSSGNNSAVADVARIRAARPLCILSATGLPAPGHVEHSMFVVGAGSGADAEGAAPAQTAHKPVKHKRPKTARPRRNRVSPSPVIEAGSPLQPWATAPLSRLSQLIRTSSASTASLNSPASADESDYQGPQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCS0</accession>
    <name>A0A835GCS0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000198">
        <property type="protein sequence ID" value="KAF9412184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCS0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="53"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9412184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="34018" checksum="3B736F1DB861AE8F" modified="2021-09-29" version="1" fragment="single">DEKFERVLSFALAMMTTKRTELECEFPPKMEEDLTHVRRKRLTTETGLVCLEDYPYTVSVRLHGKHWCGGAIVGKLWVLTAAQCFDYVTKEEVSVRMGSVFRDFGGRILSVVEIKRHPDYRMDQYYPEHNLAMVKVNLPITQSSRMQAVSLAVSDADLPPLFGETVVTGYGSVVTGQIREGENQELRRMIVREVSRSECRLIYGNDYHLQHDNMCLQSVIKGVALCAGDTGDPAVHFSGLNRAGTLYGIALFSGTEECAYKSKPGIFAKVAYSRLWIDKVLGDIPDHPESADSTENLIPIDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDA9</accession>
    <name>A0A835GDA9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_009128</name>
        <name evidence="17" type="ORF">HW555_009299</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000201">
        <property type="protein sequence ID" value="KAF9412090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000478">
        <property type="protein sequence ID" value="KAH9636788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDA9"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9412090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9636788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="332" mass="37662" checksum="341EA363F04450FB" modified="2021-09-29" version="1">MTVTRVAESRTEFKLKSLPDDAISSVKFAPKSNQFLLVSSWDCSVRLYDVTSNTERHKYNHELPVLDVCFRDAVHTYSGGLDQTLKMYDLNASMETLLGEHKGAIRCVEFASEVNAVLTGSWDGTVKMWDSRVPNCVGTYNQGNERVYTMSIVGEKFVVGTSGRKIFVWDVRNMGHVNQRRESSLKYQTRCIRVFPNKQGYVLSSIEGRVAVEYLDSNPEVQKKKYAFKCHRIKDGGLEKIYPVNAISFHSVYNTFATGGSDGYVNIWDGFNKKRLCQFHRYNTAVSSLSFSHDGSALAIACSQLDETQIEDPKPEDTIYIRYVTDQETKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE04</accession>
    <name>A0A835GE04_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_006760</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000105">
        <property type="protein sequence ID" value="KAF9415661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE04"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9415661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="887" mass="102512" checksum="CF0E2FBC4E39719B" modified="2021-09-29" version="1">MILQKDAFGQTLQYICNKFPNEKFVGAYFGTEPTLIPKDPEIIKLIVNKDFNYFSGRDLSEHNHKEALALNVFATYGDKWRVLRQNLTPLFSSAKMKNMFHLIEKCSHTLEAALDRETKISNEIEVKSLNSRFTIECIGACAFGVDTRTLTEEKDENPFRKIAAFAEPPPIACFLRVIHAVWPSIFYGLKLNIGGKVIDFFHNLITTVMTQRGYKSSGRNDFIDLVMSWKENHQITGDSIKNPKTGEVKKLTLDVDDDLLVAQCFVFFAAGFGTSATTLSYTLFELAKNKNIQEKVLQEVDAYLTRNKNKLKYECIMEMPYLEAVIDETLRIHPILGVIPRQLMEDYTLPGGVKLEKGLRVHLPAYYLHHNPEYFPEPEVFRPERFLDDQKQNIIPYTYMPFGEGPRTCIGEYLLISTKTIQENNTMFLYIFVTLLILLYYVITRKYDYWKVRNVPHSKPTFLLGNYGDMILRKKSFGENLQDRCNDFPEAKYIGAFFGTEPVLIPKDPEIIKLIVTKDFYYFNGRELSKFNHLEPAALNLFATYGDNWRVLRQNMTPLFSSAKMKNMFHLIDKCSCVFEEMLDREIKISNELEVRSMTSRYTMECIGACAFGVDTNTMAEGVEENPFKKIAAFVEPPTYLVYVRMVRSIWPSLFYLFGGRLLTKQLEFFDNLITSVMSKREYKSSGRHDFVDLVMSWKQSHQIVGDSISNMKTGDHKKVTLEANDDLLVAQCFVFFAAGFETSSTTLSYTLYELAKHKDIQEKVLHEVDAYLARHGNKLNYDCVTELPYLDAVIDETLRFYPVLGIIPRELMEDYIMPDGTKLTKGLRVHLPVFYLHHNPENYPEPEVFRPERFLGEEKRNINPYVYLPFGEGPRTCIEPEFDNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEA5</accession>
    <name>A0A835GEA5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEA5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019254">
        <property type="term" value="P:carnitine metabolic process, CoA-linked"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="52"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="624" mass="70269" checksum="CF93D281DE4FD8C3" modified="2021-09-29" version="1">MLPSVKVQVSRYQDCEIGHKGFILEPYVTSMQLSCNYTSAKTNKNVQKLPSLPVPKLTDTLGKYLLTVKPFLSDEEYARTTSLVRDFEKGTGQQLQLLLEKRAQEHLNWLEDWWLNTAYLEYRDPVVVYSSPGLVFPFRKFQTQNDQLKYAAKTLLAALSYKSLIDNDKIPVEMMGKNPLDMAQYKKVFGTCRLPFAKRDKLSFNNSKHVTVIHNNHIFHVDLWGDDGVMLDEEQIVQQLKKVMELSSVPNKQGIGILTSENRDAWAKAYELLCKDKTNSESLADVEKSIVVLCLDEAVNLWKYEDSNARRNLAGAQTIHGGGSQSNGGNPDGVTGLTYEHSPAEGQPIAVLTDFIIKYIEENKAPEVSSKSPKQPQLLKFNVSPEVNKMIEDAKKNLDKLVQNLQLNCFQYDKYGKNFIKSQKLSPDSYIQMAMQLAFYRLHNVPGAHYESAATRMYVGGRTETIRSCSIESIEFAKTMLNSQSSPKEKISALKSAINSHKNYTVQALQGFGVDRHLLGLKLSAIENGIEIPKLYSDPGFTRSAHMRISTSQVACKCDGFMCYGPLVADGYATCYNPRDNDINFATAAFVEHPDTDCNKYRSALEQSLQEMHDVLLKNVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEW5</accession>
    <name>A0A835GEW5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEW5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000466">
        <property type="entry name" value="Mann-cup, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="398" mass="42855" checksum="78A1A5290450F9F2" modified="2021-09-29" version="1" fragment="single">GAGSSRAGASAAGASKAGDAARQHDALFHDLMQECRHSAPGARLSAKLRTALERYRPVRAPAAALGGAREWRSSAELDAAATDMDALRTQSLLVVARVLGPDHKDTVFRLMYRGASYADAFRYQRCIDLWTWALQLRIEKDSLLSSDTCHTACALTRLMLDAAGGRLERARGLPHFGDVLRVFRLLADELPACRRLLGARPVCRAQADTFDRALRCAAHGVFLLQARAASPAERRAARAAVRGLLAADVRSAATGDTLLHLCVSRLNVVRSTYFADEPDAAAVFPHAGVVRLLLACGADVRVRNEARSTPLHVAAIPYNFSSELVHVLLAGGAHLDQPNKFGDSPADLVALNRSSRVCVLQYVSLACLAARALLRSRRPLPPGALPATLMDFLDLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEZ4</accession>
    <name>A0A835GEZ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000162">
        <property type="protein sequence ID" value="KAF9413362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF13">
        <property type="entry name" value="OSIRIS 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032276774" description="Osiris 18" evidence="2">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30850" checksum="D9907C08F8178550" modified="2021-09-29" version="1" fragment="single">EKCIMAKLLVLLTLAAVASANSYTASKLVKNIYNECLSQYSVECVKPRTLQWISQVSNDDEIKITDDLSIVKTATLEDDMGVDPRMAQDPAYQIVDKVDRFLQTHTLKVKVPEEITNSAASEYVPRSLLTDLPSELEMPLDGEEDGQVFEGRKKKIKLPKPLRIKSKHGFIKKVLLPFLLGLKFKASVLVPLALALIALKTWKALTLGLISLVLSGAMVIFKFTKPKVVNYEVIHYPQHHVEHHVDHHAPGWDAHGPYQARNFDDAHEMAYSAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFI6</accession>
    <name>A0A835GFI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9549" checksum="02F2F74DB64D6FE4" modified="2021-09-29" version="1">MSLDEQFSKVATSVRNWKTTPSNDENLALYSLYKQATIGDVNIAEPSGMVENAKFKAWTSRKGISKDDAKKQYIEMAEKLAPKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFL6</accession>
    <name>A0A835GFL6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein gooseberry</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_005968</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFL6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF3">
        <property type="entry name" value="PROTEIN GOOSEBERRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9416838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="50302" checksum="D4DD14C31A566BF4" modified="2021-09-29" version="1">MNKTRQGRMNQLGGVFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVENRIEELKRQNPGIFSWEIRDKLIKEGICDKNTAPSVSSISRLIRGGKRDESDPRRNHSIDGILGPSSCEDSDTESEPGITLKRKQRRSRTTFSGDQLEALERAFTRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLSAFNTMSLQSAFPSVHQQYEPPSTFNAQCASWQQSYSSALGSSSVLNSALAPSLHQSALTAPSVCQSALAASSLHPPTSSSFSSGNLTPLSHSSELATPLQAPTEPTPPSSSPSTTSPSANQSSALTYQHSTYANPSEPVSHPYGYGDYSKQEHAMSAHNHWTTRQLSGHAQNKLAEVSAWPENYSSFFGTNASHYASHAHSPTEAKSGYPYLGQLGGMDMGRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG43</accession>
    <name>A0A835GG43_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arylphorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the hemocyanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="128"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="255"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="534"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="834"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="961"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="1240"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1540" mass="182894" checksum="EAA1E8ADE262C9D1" modified="2021-09-29" version="1">MINSAICDTKQRSREDWNFHSTRFLVSITTEKAGNVVVAVVIVLMLFKIYLLAPIGIDEDRKHVKKSYPAKSRVTADNDTQLTSEDKLSAVEATMKTVLVLAGLVALVMGSAVPHHHNIKLKPVGPKFVEYQKKILKLFEQNEQLDYHSDYYKVGKDYDIEANIQNYSNKQAVDEFLLLYRTGTLPKYYKFSIFYERMRDEAIALFHVLYYAKDFDTFYKTACWAKVYMNGEQFLYAYYIAIVQRADTDGIVLPAPYEVYPQFFFNGKVMHQLYRTKMQSYPFEDKFAAQYGIVKENNNYVFYANYSTSLSYPNQEQKLSYFTEDIGLNSYYFYFHSQMPFWWKSEKLSVLKDRLGEVFFYYYQQLLARYYLERLPHGLGEIPEFSWYSNFKSGYNPQLYAHYTNYAQRSNDYNLHNENNYEYIRFLDTYEKTFFQFLQKGEFKTPEKEMNYVGNYWHMNSDLYAEKSNKDLHQYSYEIIARHVLGASPKPFDKYSFMPSALDFYQTSLRDPAFYQLYQRIIDYLIDYKQYVKPYDHNDLHFVGVKINDVQVSELVTYFDYFDFNATNSVYYNKEELKTYPVNYIVRQPRLNHKPFSVKLDVKSDAASDAVFKIFIGPKYHANGYPVNIEDDWMKFYELDWFVQKLVPGENKIERKSSEFVLFKDDSVPINEIYEFLDQAKVPYDMSVQPDNMPRRLMLPKGTLGGYPFQLFVFVYPYNSVKKGDNVFESYILDNKPFGYPFDRPVREAYFRQPNVFFKDVRIYHKDAYLPYELNVPSYFLQNKIVPSLPSVQLSAVEATMKTVLVLAGLVALVMGSAVPHQHDIKLKPVEPQFVEYQKKILALFEHSKQLEYHADYYKVGKDYDIEANIQNYSNKQAVDEFLLLYRTGTLPKYYPFSIFYQRMRDEAIALFHVLYFAKDFDTFYKTACWAKVYMNEEQFFYAYYIAIVQRKDTTGIVLPAPYEVYPQLFMNKDVQSRMNYVKMQNGLLNEKLAAQYGMVKENSNYVFYANYSNSLSYPNKEQKLSYFTEDIGLNSYYFYFHSQMPFWWKSEKLSVLKDRLGEVFFYYYQQLLARYYLERLPHGLGEIPEFSWYSNFKSGYYPQLYSVLAPYAQRSNDYKIHNEKNYEYIRFLDTYEKTFFQFLQKGEFKTPEKEMNYVGNYWHMNSDLYAEKSDKDLHQYSYEIIARHVLGASPKPFDKYTFMPSALDFYQTSLRDPAFYQLYQRIIDYLIDYKQYVKPYDHNDLHFVGVKINDVQVSELITYFDYFDFNATNSVFYNKEELKSYPMNYLVRQPRLNHKPFSVKLDVKSDVASDAVFKIFIGPKYHANGYPVNIEDDWMKFYELDWFVQKLVPGENKIERKSSEFVLFKDDSVPINEIYEFLDQGKVPYDMSVQPDNMPRRLMLPKGTLGGYPFQLFVFVYPYNSVKKGENVFESYILDNKPFGYPFDRPVREAYFRQPNVFFKDVRIYHKDAYYPYELNVPSYFVQKKIYIHIIGNPHNGFGPKYSNLHCVVGPHWGFISRNNGSMGDQRGGTGDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGE8</accession>
    <name>A0A835GGE8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000123">
        <property type="protein sequence ID" value="KAF9414826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGE8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="343" mass="37591" checksum="9FCAC140895A7BA9" modified="2021-09-29" version="1">MSNINELDSLRQEAETLKNAIRDARKAACDTSLAQATANLEPIGRIQMRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNICSIYSLKTREGNVRVSRELPGHSGYLSCCRFLDDNQILTSSGDMTCALWDIETGQQCGQFTGHTGDVMSLSLAPDQRTFVSGACDASAKLWDIRECQCKQTFPGHESDINAVTFFPSGFAFATGSDDATCRMFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDSMKSERAGILAGHDNRVSCLGVTENGMAVATGSWDSFLRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGF0</accession>
    <name>A0A835GGF0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032381394" evidence="2">
        <location>
            <begin position="26"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="21748" checksum="F69C84A502717DB0" modified="2021-09-29" version="1">MKTPKMKLFTLVLGVVILGVAEIEADESESTSPDDGPIASQENNVEPRRVDIPEVVLQLKYDKGELNRIYLTQFRKDSKAWVPSVSARSNLCADLCHAGLGGDACGVSICSQLIPIGLQTALKETNQSDVTYGVPRYNVCPTLCQNQLGCPTCEPSSTEATVSLQSSRILSTYEGWAAWCNVQCRQGQGGAACNCDRTPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGN5</accession>
    <name>A0A835GGN5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Larval cuticle protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGN5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032866281" description="Larval cuticle protein 1-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12308" checksum="8A0ECAF83291134D" modified="2021-09-29" version="1">MKSMIIVALALVALAAAHPVEEIPTILRSETNQDPSGSYEFGFETSNGIKVNEQGQLKEVVDEENKPHSVVVVRGTYSYVNNEGNNEVIEYFADENGYRAEGPSVPKVPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH76</accession>
    <name>A0A835GH76_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032502137" evidence="1">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="15313" checksum="84C4169F4E8DE77D" modified="2021-09-29" version="1">MEMEMARCRSLFLCAVIVLSLLLCGVNAASISPLTLKPLDPDYQYPLLYRDQVYTNLSDVAREMFYAVNIHPSCVEKKGQCIPRGRCIERDMLYISRICYTMDRVCCYSNDIKSPTVEHVTKHPPATSKPSTDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHK8</accession>
    <name>A0A835GHK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHK8"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000177">
        <property type="entry name" value="Troponin C Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="159" mass="18137" checksum="A34F91CDBEBAC022" modified="2021-09-29" version="1">MVLDTEDWADELPPEQIAVLRKAFDGFDHNRSGSIPCDFVADILRMMGQPFNKKILEELIEEVDADKSGRLEFGEFVTLAAKFIVEEDAEAMQKELREAFRLYDKEGNGYIPTSSLREILRELDEQLTDDELDGLIQEIDTDGSGTVDFDEFMEMMTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHR8</accession>
    <name>A0A835GHR8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHR8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="477" mass="53518" checksum="DCD5C513DC07D7E5" modified="2021-09-29" version="1" fragment="single">MSVVQNEHNIPTETEDKTIAESIEHFEKTNEVAIPKTHFQHLVPYSDSDISLSDHEDTRYTTTEAENKNEENTVRQSSSTSSSSSSSSSSSSDSDSSHSTNTRSLARTARHHVTVNETDDSEVIENTPPQHFENRRNENSTSYYSSPIYTDESDIDLSDTDPTFTIMENRRKRNYIFYDSSSSSTSSSNSRITPKKGRKRSKKPSQWKQNKMKRLRNKGKTYISMSKTRKNVPARCLKEPCSEKCRLKCTTKINRDSRYELFRKFWDLGDLAKQRAFISASMIDVQPKYKYTNSERPRNNNKAFHFTVDNTMIRVCKTFYKATHNDDIPIQAGQAVATDSADMLTAITEECEAEAAPIQRGAAVRSSKPKLSAFPVLGKKTKDSKDKSANSGEKKVTLKESSKGIWNSLSGGGGGDMVDAQQKSNITDSSVEANGSMKDEKMSMTSMHNSTENSDTRSQVTSDSLDIETTPRFAAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHV9</accession>
    <name>A0A835GHV9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHV9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="274" mass="30600" checksum="311D6D34855286E1" modified="2021-09-29" version="1" fragment="single">MSGDRKSSKAWQFFTDLNNNKAKCNFCQKEFSYKGGGAYNLIRHTKSKHPHVFVAIRECPLLESTASATEIQHPSTTTVSIARELNTLTASTSTASAACMPEKPDSLPATTAIFKAPATNTKLTQYFCKPLSAKKTDQLNKMLVKVFTKNYLAFHLVESPEFKDFMKELNPAYQLPSRKTLSNALLTNVILISNALKKNCVKFLSSSHPDCVLRMAQVLLNEISTRFSGIEDNNIFAESTILDPRFKKYGFENKYACDRACSNLKAMAGRIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GID6</accession>
    <name>A0A835GID6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GID6"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="14150" checksum="1A5E367D216540B1" modified="2021-09-29" version="1">MFRLYNLQKILPSNISSLRFSICKYSHNTTTPEAAEQTEKARDESKRPQSKRLEEFRKKLRETTPINDLGEQPTMHPSQKDENPLPPWPNDINPHTGEVGGPRGPEPTRYGDWERKGRCTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIN0</accession>
    <name>A0A835GIN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28022" checksum="BD77854EA3D61859" modified="2021-09-29" version="1" fragment="single">VRLSNQKSAEMMYESILYNYNFNISDFRYLFQYFVLYSILFVICEQLRTITRSIDRELSPPRDMRENVEQAGDLSSETVSHDKINKWVKAYENINDTSNLCNAMFSIQLTVMILIVTVYYIILMYSIALISVEGSQTMPTSMFAHLFSMAIFLTALFVISRAGQNVQNSSLQLRQKLCELCVYTLDNEECYKLAKDLLRCVRTRPVRIHVFGTLDVDMSMLPSIVAFFTTYTVIALQFNNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIN1</accession>
    <name>A0A835GIN1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000101">
        <property type="protein sequence ID" value="KAF9415818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIN1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032958967" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="67" mass="7465" checksum="E4138EA0F3176FD6" modified="2021-09-29" version="1">MKLLLIALLFTLAVFVTNVTAQDVRVSVDGRRGGQSCHTDSDCPDLCNCIEFTCKCFKRSLDLLRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJC4</accession>
    <name>A0A835GJC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_018008</name>
        <name evidence="5" type="ORF">HW555_005329</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9628033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06713">
        <property type="entry name" value="PDZ_tamalin_CYTIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052122">
        <property type="entry name" value="Intracell_Traff_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963">
        <property type="entry name" value="GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963:SF5">
        <property type="entry name" value="SHORT SPINDLE 6, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9628033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="622" mass="70724" checksum="A7B1B3DB70E6661C" modified="2021-09-29" version="1">MSSPKLNERCPSTMSNGKKLLSNDSKEDSLDNSIRESIKSERPGKNEEDWRRRTIIIEKKNGSYGFTLQSYGIHYKKEQEIEVITYVDHVESDGPAAAAGMREGDVILSINGTDVERADHAAIVDAINHCDSRMRMVVIFEDCVRKVELHLKYINLQRTLQSKMRELEQLTVRERQMFDCNWKTHSLPSQKKKTSPSDVISDNEENNIGENMNNAYCRPTLSSENVTAAKPPQPSVFMYQYLDPRYGACLIQPNLRTGSFVITVGSPRNRRECHHYVVKTPGQECHRASENYKTSSGKHNKVHRSSHSHGCAPCMPAYNNQDANSLEAYDLASPCCDPHCVPNTRKKMRRKRECSKEHKRKEKCQQVDKSTQKPDSGSHMRPKKVCQSGHCSNRYRYLTTESTQTSQCSLQSYATSNATVACDNSASSYSTSLSSDTLFWDNDRGEAKSSPKIQYQSSHQHVKPKSWDNLTTKAFGGYGFGYGYLDTTTKQSNRSKSHGRNHSSRSTQSHHEYQHTHSQEKHSHRQSAPHHCSVYSRSHSHCPPTKSTESLIMVPKYQLESSGSESRLACDCVESIDYYRRVSTSKSPAEQHSAAYYTQHFIYPTHSYKKKDPNISSEITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJM2</accession>
    <name>A0A835GJM2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="57"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="24351" checksum="B32B951F4A5FE9BA" modified="2021-09-29" version="1">MSDDRILELLGDGTKSDIEEFHDKEDSETEPRVLAELVGEEECSEASSDEIEPERLSQTGQELKTTKAEIAKVFGVHILMGCLPYPRMPMYWRANMRIGLIADKIVCDRFITLRNALHVVDHDQPTETETSNLLWKVRPIIKRVRDTCNRLERVPSYYSVDEQMISLRQVVKNKPRPVGFKNFVLTTSEGLMLDFEIYRGANTWDLLLYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJN6</accession>
    <name>A0A835GJN6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJN6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF7">
        <property type="entry name" value="RH09188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="409" mass="44127" checksum="31C65A5CDBE48FE9" modified="2021-09-29" version="1">MCASIHSAATPLGSMLSGPIMEAIGRKRTLQTCTLPLIIGWIIIGTASHHALLLLGRIVCGFAVGIMAAPSQVYLGEISEPRLRGLLIGTPFVAYSLGVLYVYALGGALPWRSVAHLSTVLPALAFIALCLSPESPTWLARRGRFHDAMAAMARLRGDHDTNVLVHCKAEQFQLLLERLKNSRFSNLPQAHLFQLATPDAQRELHELISAREKEKARGEEKIKFLETVTRAPVLKPLLLINAFNILQILSGSYVVIFYAVDIVKDSGGALQPTMAANASALVRLGVTVVACILLLRITRRALVLVSGIGTAVCTLALSFLLYQGPGSGITPPVLILGYVAFNTLGFFLLPGLMIGELLPTKVRGLCGGYIFCLFNSVLFGFTKLYPVMKNAIGIAGVFGLFGHRHYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKK0</accession>
    <name>A0A835GKK0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKK0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033049035" evidence="1">
        <location>
            <begin position="18"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="381" mass="43255" checksum="687C276A699085BF" modified="2021-09-29" version="1">MKVYIIISLAALSSIKASPADNKRNLTFAATVIFYCDLNGDKLVAAGKVNKAIEDIIREYIQTNIKDVPVEVMPIYEEISEVPPVEELNKLIDDKYKQFYVTYVPLRVILKVLEEKLPKFKPKYLSDLKHLRLNSFAKDVGNLIQETSAYYGNKAQMEKRFFVGPYSSLILQYILIHLEAILSCLSITLAENTETKTNLTVTVLFYCNNKGNKIVAAGHVAMKVESIIKKSLQNMLNYAHIEIEPAYKDVNDVPPIETASDLMTQKHKLVFVENVPKIVISKIVAHKMRMIANRTSHVKHYDMSNYTKSVTSLTKAVLNKNLDSLPKKFNIAPMIIHSFIPNSVCFAVSLTRDPVLHKYSNFKGILFKMSNAWKKIKSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLD2</accession>
    <name>A0A835GLD2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_018094</name>
        <name evidence="3" type="ORF">HW555_004981</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000281">
        <property type="protein sequence ID" value="KAH9640428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLD2"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000112">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9640428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="245" mass="29125" checksum="519BABE129B49047" modified="2021-09-29" version="1">MSAASAAKSDSFDEFYTEVKEIEKRDSVLTPKQQLDRLLRPGSTYFNLNPFEVLQVEPDASLDEIKKKYRRLSILVHPDKNMDDSERAQQAFEIVNRAWKTLENDDTRKKCLDICEEAKERTDHMIEQKRKKMKKDNKLAEGIPEDDPVKYKHAIYVMTMKLFADMERKRQHLEVRDMEERKRKREAEIEQEEQKSLEKEWAKNFEESRQNRVDSWKTFQSGGGKEKKKKKIQGFKPPKPKPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLL3</accession>
    <name>A0A835GLL3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_003655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="612"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="270"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="791"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9419943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116223" checksum="477C78D9AC0608C8" modified="2021-09-29" version="1">MFWYKRCPISIKLYLPNVKASVTITGRGIPYVSIVVTGVLYTTSPVGSPGDCIDLLLCTNLWFFFADESEIGLRPVMDCLTRGENGLLIAPVMHIKSIVLDGFKSYGNRVEINGFDPEFNAITGLNGTGKSNILDAICFVLGISNLTNVRAGSLQDLIYKHGQAGITKATVSITFDNRNKDQCPIGLENNDEFTVTRQIVMGGKNKYLVNGLNVQNKRVTDMFCSVQLNVNNPHFLIMQGRITKVLNMKPPEILSMVEEAAGTRMYETKKQAAEKTIERKDAKLRELNEIIRESIAPKLQKLQDERAQFQEYQKVVRELENLTRLHIAYNKLAQVKDEIKSKQEQIKQNEADVTDFEKQISELSKKVDEESGAALRALEAELSELGAADAGAAADERAARDALHSHSARGRLLARALADDEAAAAAKRRALDQVRAAASLRPRLLYDLHVESTFESLREKHQNSTAVLAEAQQKFLEVSSGLEGASESLQDQLMGSYPCIEFGVLLSYYCTDYCLAGRKRSVPAKQEASEAATRISQSEMEKKHAENRLRALEREFDSSSAQFQRDQENIGRHEAQLAELQKPEPGFDDKRVYGMSNYFIHYLNYSTPFLTDCIGFRLIDVADPIYCTALETAAGGRCPCAAVQRGGGHGGDQQAAPAARGAGAQDHHHPAQQDQRTRHRPRHRAAGAADRTSPRPRYMLGSAPARPDTLCLQGGGPDNVQLALDLVQYPAELRPAMAWVWGGTLVCRDLDTAKRVTFHPSVRRRTVTLDGDVFDPSGTLSGGARVKGGSVLMQLQELKQLEEEHKAIKEQLSQCNEELKSLQQAGEKHTSAQQKEFKKAEEALKKAKKEAELHSNSWKQHEQELETLKLEVSELEKASAVKDMQSRIKSQKAEIASRNTEISRLLQKKEKLRKNNGELELKIQELEYKLNELQTEAAELRAKYQELLHKKQIVEADRAKLVAVMAELDEKKRKTLVAACEQVNKDFGSIFSTLLPGAEAKLTPPEGQTVLDGLEVTTDSFITDFIEYLNLSCRLTLYNHNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLL5</accession>
    <name>A0A835GLL5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032448181" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="288" mass="32217" checksum="DE6DC028749A98D9" modified="2021-09-29" version="1">MELRRLIFICLCFIRANGQFYHYNILTRVIQGVPTSIVHYPIMAQLLLDAWGTQEYVQHCAGTILTSRHVLSAAHCFQYNANTGRNYTMPKYWKIRVGSTYRTGGGVLHNIKTIIPHKDFDKFFYTNDIAIVVVTKQFSFNSNVRQGTVIKQGVEIKPDSLCTLVGWGVLESSDHSLETPGKPQRQTDGPQPDQLQHTNLYTIDQKICAMRYNTIGAVIQDSMMCAGRVDGGGPDGCFGDSGGPLLYKGLVVGIVSFGYSCGHRYYPGVYTKVSHYTNWILRTVGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLT9</accession>
    <name>A0A835GLT9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLT9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000076">
        <property type="entry name" value="phospholipase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF177">
        <property type="entry name" value="IP13478P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032497093" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="334" mass="37551" checksum="82F2B9DA30818A00" modified="2021-09-29" version="1">MFRIVLLINFIYIHIYPTTVTGYDCVAPPLECPNDNITFWLYTRKNEDNPHQLVAMDANTIDNAPWVEDAPIKILIHGYTGNKDFSPNTEIRPAYMECCNYNIISVDYNPIAREPCYIEAAKNTELVGMCVAQLIDQLVQKHGFSLARFHPIGFSLGGQIAGFIGDYVTSGTMERLTALDPAMPLFVTTDNGKKIDKEDAKFVDVLHTNALEKGKLEASGHVDFYANGGITQPGCKSTKEQTKSGCDHARAPAYYAESLTTDVGFYATKCYSWIIYMIGWCEMFNPNEEVLFGEHVPTDVQGLYFFSTNSESPFARGSNKRGRRKRSYDFNLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM86</accession>
    <name>A0A835GM86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABCC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001726">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="43"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="410"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="709"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1301" mass="145267" checksum="0B802370C800F135" modified="2021-09-29" version="1">MHYVVLFFRRSWLKAEYEAKLAGTKPKFAKVLFKTFIWSYIPGGLMQATSIGLRTASPLLFSQLLRYWSAESPVDREAAMYYAISMILANWASAFMNHHGVLYCQQFGMKLRCAVGSLMFRKIMRMSNGSLGDTAAGKVVNILSNDLQRFDLCMMFLHYVWIIPLQVAAVIYLGYLQAGTAAFIGFAALIIIALPFQGGLGQYLGKIRLRTAEKTDNRIKVMSEVINGIQVIKMYAWEIPFQKVVGQKRAEELKEVKIATILRTVFLGFMMFTERAALFFTVLTYVLMGNVMSANVFYPLQQFMSAAQVNITLILPMVLSFTAELFVSLGRVEKFLLLEDRPDLKGHPEETSSNLFRNLSADGKPETNGSIRPLSYHRKSDAVPAEPGSELQLKVPKLARSISYQEDSALVLHDVSASWTGDPNMMALKNISMRIRKGKLCAIIGAVGSGKSSILQLLLKELPSATGTISIYGKMSYACQEAWLFPSTVRENILFGLPFEPGKYKKVCRVCALEKDFKQFPYGDQTLVGERGVSLSGGQRARINLARAVYREADIYLLDDPLSAVDANVGRQLFEGCINGYLRGRTRIRILVTHQIHFLKAADFIVVLNEGRIENMGTFDELVSNGKEFSMMLAQLQEGKEKDAESVGSRSIEEKEKPALKTMISVNEGEELQEFEAQKMKEEERQSGNLRWEVISAYFRSGGNVCFILFALLVVVLATTCAASVDYWVSYWTNQMAAYEKSLGGESIEPGLDVQAGQFTVGEYLIIHGCLVATLVLMVNLRVFPFAYLCVSASAKLHNQMFSTMLRGIMRFFDTSSSGRILNRFTKDMGSLDEILPRTLLDVLQIYGTLAAILVLNAIALYWTLVPSAVLLILFGFMVRIYLKAAQGIKRLEGTTKSPMFGTVTSSLSGISTIRASNAQERLIEQFDSNQDLHTTSWNSYLNGGTTFGFYLDTMCLVYMTTIIFVFLFIDFGDAIPVGSVGLAVTQSNTLTLMLQHGARMLVEFLAQLTSVERILEYTRIDTEPDLFQGKVEMPPNWPHQGRIVFQNVSLRYAPNEQPVLKNLNIVIESGNKIGIVGRTGAGKSSLISALFRFAYVDGLISIDGLDTSLISRQGLRSKISIIPQEPILFSATIRYNLDPFDIYSDDDLWRALEQVDLKSAIPSLDFKVTEGGSNFSVGQRQLMCLARAVLRSNQILIMDEATANVDPQTDNFIQETIRRQFVSCTVLTIAHRLNTIMDSDKVLVMSSGQVAEYDHPYVLLSDPNSHFSAMVRETGEKNSANLFQVAKDAYFQSNLKENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMR2</accession>
    <name>A0A835GMR2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,4-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9422030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMR2"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="141"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1139" mass="128322" checksum="59295C20C0DF9CB0" modified="2021-09-29" version="1">MPKLAALASQTSQNFDREGVLVLKERQDGFFRRSEGCSVRWFRLRGNLLFYLKGPEPWYEPMGVIVLGHHHIKVQSQDENGHWPFQITWDNSVCYKMATFHESERTLWLKAIELAPYDNIQAQADALRERLNKIRPNLDIATYRLQKGIVTDMNEVPLCELALSCDNLLCDTHGRPPSPLVVIYVKNDKGLCIKYGATEIVETCSNPCFSKTILFRASDGLTGSALVRIVVYDVKERVSETIVPMGYTSMLLSTIQEAQRLRVALITRDQKTVGFVTINGWSLEPSYIGTSPSHTNDRNCIDIPHKVLCHRRSQSLPPRLGLKLKFPSYGSLLKQNFVNSHQVTYRFHSGLGGDITVHEIMAEPKLCFTMPIQLLREKELLDELLSVGEICGQWQTRQLDLVSTHVSLLKHYCHSRRCMLSMENQHFKASSRKDDASLEFAPINLHLQRMWVHNDTLNKTGFHDIVTVGAFATHTHKSERTGGLIRLVQQVKDINSTKAEMNSITNKIQAEYDNLVAVRRLREGISEDMEKILMLMQAQQYGAITPVVEGIKSKAKSILAQWEPAVVEESLSYIGWPKNGSPDEADTHNETQQTMSTIMRLTEQLSMFDTNSDCDTFDASSSSSSKETSPTGETPTLSSSVPNISNYPKKKVPETELQFHNDYFKNEIEERDRGGLNHSFRSVRLSKPKIDGQSLSFDYTKRHGSLRHDFKSSASLEQVSYRSLVDSLRNDKRKAIELRRESATLPAIGQLDQATRDNNLAFLRNVGIVVEDSLTCLVEELNRIVINNASSDEDLERIKGLMDGVRSSADDAARWMRLAHAAFRLRCESPLWAREHAALQTRRDTCFSQALSTVTAGLLCWLCSMPGDIVAKILSSGLGPLCGFEGLLSLYSTEKAMWGDMVVAVEDLQTVVFTLTKVGHSNSAVPHVSGTRGALTVYIPISDSLYTKFNSKEHLSFTITAVFFNIGVNEKATLAEALGETTPQYHSNSDNLDRLNKYYHKYSKIFPTDHMAASRASSRTKPLEEVMETLRICVHKKVPKNVEVLHLAALATRLMNGIRFTSCKSAKDRTGMSVTLEQCSILASEYHLAEHEMKKALSIMRSEGCRRENTQKNIGIRKYAFTKKQVMALPADYRPPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMV3</accession>
    <name>A0A835GMV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_006487</name>
        <name evidence="7" type="ORF">HW555_004235</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000334">
        <property type="protein sequence ID" value="KAH9639514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMV3"/>
    <dbReference type="SMR" id="A0A835GMV3"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9639514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="14835" checksum="F43B0DC42654D489" modified="2021-09-29" version="1">MSKRGRGGSAGAKFRISLGLPVGAVINCADNTGAKNLYVIAVQGIKGRLNRLPAAGSGDMIVATVKKGKPELRKKVMPAVVIRQRKPFRRRDGVFIYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNASSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN55</accession>
    <name>A0A835GN55_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_002565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN55"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9421632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14426" checksum="1C3EB2069F4E4DC8" modified="2021-09-29" version="1">MAVNSATSFVLSSILTLLIFSGMQMYKPILVRSPVTIIFGGYLGSLMFMFFVTAIGNLEATLFGKNFQLKLPEVVISMAISLIAAGMVHRICFTTCLIFSLITIYYMNKLSQKTYAASAPVAVPTKSRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNR9</accession>
    <name>A0A835GNR9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNR9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1212" mass="137999" checksum="9C1F7E41AD27D253" modified="2021-09-29" version="1">MESGTTKAFTPAVEETQNVANADSADSFQSFIYELFEKNGILNDLRAYLRGHIVNVLKSAQTGDPHPCQKHFAQRLELTHQAVNILIAEYLMRLEFSYSFSVFISEIPLANMVFGFAKSMMERSHENKMDLRFKESDIWSILNYLGVQCDSEHATNVVEMYKRDKHIPLLLCILKCMPLYKENVGVAQVSSEDSISSIRSEYSIEKRAHSKTTPSSERCHHYTFCKTCQNKMYRLKETYKRKKKYFAKTCKDNANGNPANLENLINNINVVEKSLIEEMFQQLKSVYEAEVEMVKIEEEKKVKRSMASHAIKLQRERDEMEEKFKAREAELERRVTAKKQFLWGLARALRTQHASMARAMTDVKTETRRLELKEDSLKSQLAEAEQILKKRGEAMQLQISKELSILEEHLESMKKERENITRERSELENLKTVQNSPGKCVKVHEMETEEVHSHYDLLKNELAILKKYLESSRLSAKCVIERGTITDPIQSVSKVTVTLNNSQSNEKCSKSDDVDDKVKTNQLVNDFRKKNVNFSQSNLDELYHETSRERSRSSVSSEAGDLELERAKDRDLIQRLREENDRLKAFARQQRTRIEQLSGSVQVPTRPRTAPPAAVRHIYNSASVNTLNVGWRKGAGEELSVFSNAQPRILVPGDTLPFIGVLRDRHGNARRSPIGSRSTRIRAWPLAGVTKRAASPLRDRLSNSAGSSGLGVGGAALAGPSCALIHDDDDYRSPPRELPPRTALSLELNAEKSPHSVFREAKEKLRNKDCVIISPPIMPRDKSPNAVLREAKLRLRKLEIEAEAVEKSYLDFRRKQSELRLERNARRQRDAWDDEIPQLVEVKTKRSQSLEKLDEPSKNEEQPFTDLHKSIRNDFENYIREYKNKFNIGETHFRSKPTVAEKVKPIPGAYSDAKHRDCKADNDDQGNYLEQPLTEFRKLYTSARHICRDEIDTNSRIIHPENTSDTSRTELEEQISNRQEAIINTKNKKQAELEILKQNLNKMYNLNNSNLDFNVLAGTSENEDCQEVAQNADDNILRVEVENTNEWKNLESKTQELVLVVQSSVTAQEVTLACNEAAPDDVSAVLGSAAPSLPRLVAATEAGLSADSPQAYLSEASPPLSRRGRSESPDQASHFTRNDALDADPNQQTSNSQMQLELSKEVLDNSVSDYGKGEYADDFSADVDNYNSRSDYENHSPISLPKTSEDENFWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP63</accession>
    <name>A0A835GP63_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP63"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="353" mass="40271" checksum="C0E2553FECD097E3" modified="2021-09-29" version="1">MYSNMQSRSARLVSAALRNDKGVGEWSPEPSTSGGVQHSVQASSSEHVVAPLSVLDTESDFDSDDSVLDKNYELPKVREKNSDTDGTDSEDFIPCSQPLPAKTILESPAESEDEETNHVQLTKKGTIRKRKTYNVSIKDRKRLKAEEKIRNKYFVKPGCREDVCKKNVQHTFQKTRKKYEEDADNQTQKKNNADTIIFAVDLEKVIMLPRMDEFKTVMFCPRLIVFNQSFVPLGDKKIHEVDCSSTFKLKNSNPRAYLNDIVEANFRRGGHLLFYKNSHGTDEYFELDFLRLKDLKQGIPAPRQKHTPRGITSERKSAILTKLGPLMPANRRHFWESLPVNDGSADLTHIHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQC4</accession>
    <name>A0A835GQC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF86">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033041329" description="Peroxidase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="73049" checksum="F39B20FA451ABF5F" modified="2021-09-29" version="1">MLPVLIFLAVFCDVRAALFYDSYYGVPIGMDEVKRHSKSNTTFWCVNEFEPCDPNEGRRVDGTCNNLRYPNRGASHTPFTRILPPAFDKDYEPKKAASGNDLPLPRVLRTNLVSVGKVPSQRLTQLAIHAFVFLSSDVVSLHDTINYILWRPYCCAPRGKNDTYCVPNKIPNDDPVHRFSGHRCLNMTRPETFQSIGCIPKGSTPERIVSSTPGIDLSSVYGNFLKNLQEKGRLYQGGLLKYEEDSGRIWPPSTKTQANVCFLNQRPAETRCHDMPEDGGNTLGGINLMAVWLWRNHNFIATQLAKVNPCWDDERLFNTARDINIALYLQFNYYELIPAFLGYENLIKDGVITPTGEFRDVYNEKVLPQVSLEFPFALRWLHTVQEGSLKMYDLEGHYLKQFPIVNLTLRTGYFDVDNNIDYITQGSFRQGSAKIDYIADPDITEQGLGPHQSVSDLMTNDMAKNRYFGFQPYVKYREACFGKPIRSFYDLEGIVDSERIEILRDLYEKVEDVDLLAGIWVERPIYGGYVPPTFYCLTIDQLRRNMISDRHWYERPNRPNAFNALQLGEIRKYTIARLLCDIGDKVTKIQPHAFLKAGFNNKMVSCENIPAINYEAWRDLNCGLPTYFNQYGKDIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQG2</accession>
    <name>A0A835GQG2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13275">
        <property type="entry name" value="PH_M-RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039597">
        <property type="entry name" value="M-RIP_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1673" mass="186962" checksum="4524F24AE6415227" modified="2021-09-29" version="1">MRKRMRSPLYTDQPVSSASPPTRDKINGEEKARSRRRDTWAEPTTPPVTDDATVGVRSPLLQHQQYDEQLRDIAASLTRPRSRRALPPTLERPTRLPPPDRLPARGSPDGGAPPEEASSSSASEGSEPTDAVEPTENGEGGRVELPAERLLHARAGWLQRRGPGGWSRHWFVLRGAALLYFRDPHAEHRGLMDGVIDLSGISRVVELPSCTNGYAFETETWDGKHIVLSAVTAGIRANWVSAMRRTAGLPDTGPLSLILREDTVDQASESSTSPVTPVTPITGRSAPFSSDEEYRTASEGGRRDSADWGDMGPQPPPSPLLTRTPISKVKEKVRIRSSHQAPPRADTPKGDRDEIDSTKEKDRTFDDVDENEKPVEARKRSYISTIDKQSIEIDDLRKQLKLALSDVGAAEAEISRLQKLKTDAAMQEKKMEELVTALQKKEEELSVRTKEAENLDAIKELYNQDKSLWENKLTETQNFLKESTEHCELLTRQLASAQETIAQLQREVNELNEKLLKSVRENDSLYSRIRDLEGRTLVESTLPSKEKRKSIGSLSDLTNLNQDLNLEAMEKDKLIEEYGELRDRFVKAIQEIKAMKKELRDSHNMYDELEVTNMKLRNEMKLREQCSRSEIDLMAARILDLTQKLTASDKQVRTLKHKIQKSESREKRRSLSLKGRESFTLGKEVEEKLTELENKITMLESGEPVPTINSPSKSASPAKEKSSKSENPSDEKRMKRLAARLRRKSLDSATSSEPMKMLVRLSSLETKVASALENRKDLTNSCESLSQATRSVESPPLNESSEASSIGTQSQRHLLERLQSLENVVIHSRNKVNECLCQMSAMRAAKSRRSPSPSLEKKYSLKSMEKCLTDVSKRLQECFDKCVVDYDQNQNQEDVNDSVAQVVVQLEEQLRTKLLEISKRKAALYEAGELTQRKSLEILAEKLAYEAVLVGRIQEALESSNGSRFFARLIKSEIIETSQLIDNLKRKINGESSRSSAGTRSSLDYLAMILTRKIDIVNGSREAHERRRSELIIHGADLEALKASQREVAEAVDRYKSEKLAELCSALACETLSYSAPADGDTERQRANLEAARVREAWAAARDALGAELVQAEVTRALARAAATCDQRLDQARRARLTLTAQDRADLELWWQAAHDHLRCEMDAAVKDIAVRYRSCLAAERRPREGSPGLDSRVLLQQLAEALAQRALVDARVAVLDGTYRASSPREPTGPRRSAEDTISSLEADPAQEAEFVYLFQRFSTECRALFSSDCSGNSEDSMKIGESLERVEAAVAEVQRQLCARGEEPGAPPTSREGSPRDATPSGASVLDRIDALRRRVEALQALVPCQHCKQLQDALDSYRTARGHCSKIIIMTSQSAVAADTHGDGLRARYQQEIEQLRALCEKGLLAMESSHRRIVREMEDKHRAEREQLRLDKEQALAEETRATLAALDAMRKAHESEVRREVDKFKAEFLSRGHNGDLTQLSSRHHNISRQEMEEIKREILSLSEKYSVKCVESAALEERLATATAQLAQAHNHIMQLDARNKQLRAHLISEANEMKNTEGSTLSQLIEETAPHGRAPPALGEHWRHLSPARQKPAADTDEVVSSEPAVGSGEAGSPGQDTVREDREHAKPTAVARSELKASKRSSASGRPTVFSLAGMVAERKKRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQK5</accession>
    <name>A0A835GQK5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="415" mass="47449" checksum="79A7B27D8DA77F1D" modified="2021-09-29" version="1">MVRCNNNISTKFVETSAYLNYLDSFMSIDRTTLTSRFFILGLVWMLVFFFASVTEETTVKIFKLTFMCTSMSTLLTLTFIFISTKNVATEAFSQIVDIAAPSDIMLSVKHVAYAYGIGFLGIYDFGALSTYTMIDTASVFFVAVFTFLSFLRSWIIKILYIIMTKCVKIEDQYGTHVLVYAILPLTTEFLYAHKLYVFYFYGNVFLSTLTFMTYLIAILAKFLSYEFRSIKQVYIVGLLCSLGLALSLPLVAIVTSLNRPYYTLGVDLVNTYLGGAYVAIVMWLYGLKKFCTDIQFLLGFRPTRFWTISWAILPAALFNLAGIFKSHKKYGPPEIEDRKRRLHYSEFTRQRKCRHNCMVIDEWFECNHLEYAPENTGSINLSSSSDSSLMNIYEAKTTSRLRSFGTLNSQAPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQV6</accession>
    <name>A0A835GQV6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQV6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="91" mass="9792" checksum="24F057DB7A67CF9C" modified="2021-09-29" version="1">MTPNSSPTKSPGAPVWFTVGATNPTTRSFFADGMLITTSVVYGVGGLHLLIPHAREGPPPQLLQQDDDGRDQLGARRLQPVQGFRTPVHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRW8</accession>
    <name>A0A835GRW8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRW8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032302001" evidence="2">
        <location>
            <begin position="18"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="368" mass="40287" checksum="F2F8391382EF106F" modified="2021-09-29" version="1">MARKIATLLLLFAYGSCMEMRETVERMVMVRTTGSDLQPAATGYIYKKESDGPASVVKMGESEVIEHFSKLYTKPEAYKAPLPAAAGPFYAKEEDEDKAASDATEEHVKPVEENIDEHDDHIDGIAAENYDKIFEEYAKKYGSGYKNDFSDYIHGLGHFDHGIYHGYGGGKDYGLKGYHGYGEKGHEGFGKQHHFEKGDAGNYHSEEHDGFAVSKDGGNKHHYDEADAHGKHYAQGHGYKGGDHGYKADHSKGEAVDGFHKVFDKNEFKKDHDFYDAEGVKGNHHKYADGHASHGSAAGGFEKGGSHDSGHIEKGFGKEGFVDKESGDEHGAEHSSEAGGESHHHHGAHFGAKGAEHAGKSYGFEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSA0</accession>
    <name>A0A835GSA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47803" checksum="66834E43BE94CAD5" modified="2021-09-29" version="1">MSLISQQSAVSARTRKRTKTQARNDQSKDATTEKVNTINVDSTIVEKLVSDNADLRSQIVNLSASVEKLLNQYNSSSCQGMSSTFVEDLTRSIMIQVGNMVNARLEAIESRLLPEKRIRPPLAADLNKSGLSVTQTRVESSEVDSIKKGKKKKNHKNKRAVTVTAMNTTVTDLPPVLSHGIQSSSAAAVTETWATVVRKNLQRKTQPKAQVASSATQKKGRSIVLAKVPTTAAIAITIPEGSSATYAEVMLEARQRIQLSQFGIESLKQRIGMTGGMLLEISGADCNAKADKLATRMQEVLADIDVRITRPCKMGEIIILDVDESVSSVDVATAVAEAGGCSPDDVKVGVIRRQLNSLGRVWVRCPLATVKKLSSNSRLIDGGFAREYLENSVLKRGCVSESTLLEIRDCLVKLTNPRSVSRIGPSMKIVLATFLKWIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSE9</accession>
    <name>A0A835GSE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057809">
        <property type="entry name" value="ZCCHC24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23490">
        <property type="entry name" value="ZCCHC24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="91" mass="10562" checksum="238D6D1DB444CAEC" modified="2021-09-29" version="1" fragment="single">TFCFQTPYHGKKRCFGEYKCPQCNRVWMSANSWANYGQECTACKINVMPHKQKPLEKPEGLDKSDPKKKHPMELCQKCKKLGTYCGSTTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTC9</accession>
    <name>A0A835GTC9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_015184</name>
        <name evidence="6" type="ORF">HW555_001055</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000203">
        <property type="protein sequence ID" value="KAH9642063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTC9"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9642063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="23696" checksum="7F5D511528E384C1" modified="2021-09-29" version="1">MSLCQIFVIAYLIKIFNIALCYMLVHPVKQHFLYFAYGSNLLKRRIKINNPHAEFVGVGRLDNFRLDFVSHYNLWGGSVATIVPHIREHVWGAIWKMQYDEMPSLDKQEGVDLQQYVPRQVNVYYPDGKQAKCRTYQHMNFPVDVTTLDCLPENRRPSITYKQCIIKGAYECKIPKEYIKKLESIPTNGKLASETLRKFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYQ5</accession>
    <name>A0A835KYQ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000637">
        <property type="protein sequence ID" value="KAF9406131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYQ5"/>
    <dbReference type="SMR" id="A0A835KYQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17067" checksum="E4FB29CD9D999C98" modified="2021-09-29" version="1">MSKALGTSAKRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPPGSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRIARLWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYW7</accession>
    <name>A0A835KYW7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">trypsin</fullName>
            <ecNumber evidence="9">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_011383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000332">
        <property type="protein sequence ID" value="KAF9409166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYW7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033032917" description="trypsin" evidence="11">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9409166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="260" mass="27681" checksum="32877F031C2DDC56" modified="2021-09-29" version="1">MAKLACVLFLVAAVACTNATPNRIVGGNPTTIENYPSIVQIESRTGIIWGQSCAASILNTRFVVSAAHCFSGIFNTRNRRIRAGTTNRGSGGTVVSINRIVNHPSYGRNQMDGDISVIQLSSALVYSERIQQVPVIPQGFELPDNLPVVHSGWGTTSQGGLASAVLRDVQIYTINHEICAARYASLLIPRRVTENMICAGLLDVGGKDACQGDSGGPLYYDGILVGIVSWGRGCADAVYPGVSTKVASYTDWIVETVTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZC6</accession>
    <name>A0A835KZC6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012712</name>
        <name evidence="3" type="ORF">HW555_013708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000702">
        <property type="protein sequence ID" value="KAF9405660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000499">
        <property type="protein sequence ID" value="KAF9407173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZC6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="36876" checksum="3475FC9C6FAC6B36" modified="2021-09-29" version="1">MANMSTEETFKFLELYQAENCLWNPKNKYHKNKNVINDSWKRIADTMGIPVHELKKKKDNLLSTFRTNLKKRNASIRSGAGTEDVYQPIWIFYDVMAAFLTDVYESTSILNTEEKTQPDLYEEGSASNVQVSDNIPDAKNEDHNDANIPTTSQNKPIIQSQKRRAKDPPEMQEANKKMSTAFTALNKALANKENIKEEDECNLFCKMLAKQIREYPKLEREEIMYELHGVMMNRRRRYNTMQGRSYAVSSPSQIILSRPSTSNSMYPSTPSPIYVVDSPIQFSHHHKIWPINKPKWLTLFHKKYLYHKQVKCITKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZQ3</accession>
    <name>A0A835KZQ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZQ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="462"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="621" mass="68772" checksum="A80B42BCAEFA01F8" modified="2021-09-29" version="1">MAEAAFSVDGKYYSAITQDGRLRIWDTETNVLKQEYTPDLHLTSPPSCLQWISATQSANTPKGGRRKSVSEETHHIALGTTSGKILIYSVAQAKVETVLSNENSHSGITSLDWHAKYGLYSCSKENSLCEWDLQSSLIRYKYNVSIESKSKHGNIRAIKIVPHKQNTAARYLVAASYQVMLWRLHDGEATIIKNLGHNAAPTALLSIATLNDVCWLIEGSQNERLLSFWDVTITDEHVPQMNGDETPHKKQRRKSISKAPTTTATPTYNFVLEDAPRLVDVELKNEDGATKLSLAAATRSGVVHYYGLMLNGSSTKPIKPSVTIQVTSADARPLPLQCCRLPPTGELLLGYWNGPVMTFERVKPDLKTKTQILIRGEKEPKKKGKQDAKKVRENDTSQVTYVEPLGASQGNEPRPEIRSVKVEVPMEARLANLALDVKGRSKSAVSQNLTKLLMQGLIPRTKVLQKDDPMVALRTVSNLPADYVPQLLEQLADMATRKTSQCASVCTWLSAVVRCHSALLLATMGSRSSDHLTQLLAIFTNRRSHLCQLLNLKGRLDLTISQRSASDIAHEEQQPVLNYNDSSSDEEMEAEPYQSDSDASWGDDKFESDASAQDEADSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L130</accession>
    <name>A0A835L130_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L130"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="208"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9412364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="455" mass="50936" checksum="281E5B1DA588DA6E" modified="2021-09-29" version="1">MFLTTKIRPDEELPEPTLRIMARSTVYNVGETKAIFCKGQNLVEPIQWYSPSGKLVEERSTKNSRVFVERKTEDNGVLVPLIIHRIKISDGGNWTCKAGNLTETKEFIVGEKVNITDRNVTLEGEEGKSVKLTCEANGYPLPVVVWYKDKHQIRDKEDPKKYTIKPDNTLEIKKLNHADVGLYVCKVRQKALSHYTEKTVHLSVQHKPILYNSDTQMIYTNTKYKTEEVYAILNDTKNVTCSAIANPPPTYRWFRRINGYDDDAITDPDTVITSEDGTNSVLVLRIRDESYYGEYRCSANNSKGSESIIFHVNPGSKPLPPDTVQLAAANTTNLTFNVTCSSCNFATPDEVPESPDPKNLTVIGYIFQLAPSKPGYPADWDGAPEFRVDIESANNTLFTLGPLSNSTVFHVRVRTRNAAGNSEWLEAGDAATTDDAIRLSATLLLMIAAICMHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1T2</accession>
    <name>A0A835L1T2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000242">
        <property type="protein sequence ID" value="KAF9410881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1T2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10505" checksum="204B63E6A8A2420E" modified="2021-09-29" version="1">MVEDLRAMSAVNLLSSLREKPTDENPDDGSNPDDTTKGLHDTFDWAWVVGSQASYKSDCVTRSLRQPLPSCVQGLISQGGSRPFGFGPFAPIVHNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2H9</accession>
    <name>A0A835L2H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="14000" checksum="3213B5FB881F104C" modified="2021-09-29" version="1">MATNYAQYSQLIKASTNYARRMQRLSNRIFSEVAIPTNPKSMKVVKMFSERPLHTNEDIIHYYPRHIETHSLMLKLREYGLFRDEHQDFKDEMKRLRELRGKVKVWRRKLDQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L315</accession>
    <name>A0A835L315_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insect defense protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000151">
        <property type="protein sequence ID" value="KAF9413770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L315"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF40">
        <property type="entry name" value="REELIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032452233" description="Reelin domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="8">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9413770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="166" mass="18418" checksum="9E036FE98DA1FDF0" modified="2021-09-29" version="1">MFTKLLLGLILCWGVWSFPDGAPIDTCVKNRANQPNHGQHRTQPLSTLPYRVLASALVYGPNTPVTVTLEGSEPFKGFFIQARSVENDNWIGSWEPAPNTTIHPECSSITHGDPEFKTRATLLWRAPPDAHGRVYFTGTVLKNYGTFWSDLIAEAPQDPSQLQILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3B1</accession>
    <name>A0A835L3B1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3B1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032978867" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="134" mass="15081" checksum="30761A3FF4B83069" modified="2021-09-29" version="1">MKMKSVLLIALLAVTYVYATVDLSEAEFRRPKENASNLRLILGSKSGGDDRLLSKTYHYVERSHKIAHRQEILIRLVDYARITRVEGWPGNPDLGLTVLEGGLGQNFIKLGYVTAENMDFSYTIDVYGVLVCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3X5</accession>
    <name>A0A835L3X5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9414012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3X5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="596" mass="69061" checksum="3F968386E5192E08" modified="2021-09-29" version="1">MGKSKKKAKWIPASITDIIAEPTTIPTTHNWADSVDEEPENAYGGGYQSRPRAPVVLPSASRAARGGLAVDDESIPRRPPFTAHISNLPYDVDESAITELFAGLKITNLRLPREGDRLKGYGCVDFEDREGLINAMNIPDLTIGGRRIRIELSTQDNDRRMGRGRNDRDREYDPERTMGDWRSGPRAMPEPSGRPRTDERRMDRSNMDRDRDREPSADNRPGGWRDGDRPAPPEPARTPYGGRDSFGRDRYGEGRERGGGFGGREDRPERSGYGGRDGFRTAERDGGGFGNREGRGFGGRNFGDRDRDRDPPPREDTKPRERPKLNLLPRTVPRDPEVPTKPADGAVGEKLPEKAAPKPVPAEKLKPVDTAAKEREIEERLRKQQEEEARRAGEDKERWGRRNDHSGDRRPAPKRDDRPRDSRNYNREKRDYSKEDPREYNDRDRRDYRDDRDRHGERDDRDKREPERDRRDYRDERDRRDKDERRDSSGDRRDRRDYSPDRRPRRNSGDRRRDASPERRRDPSGDRRRDYSGTRDDDRRPPSHERNGRSRPSRSRDRHDDTDDRTMPKLKEQEKPNFVASNKFSFLEAADDGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L423</accession>
    <name>A0A835L423_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the hemocyanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="274"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="399"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="688"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="6">
        <location>
            <begin position="1428"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1699"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1699"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2128" mass="247731" checksum="153FF362A8C65280" modified="2021-09-29" version="1">MTLDDSISYNPLILVAQTDNVTVVVVSDDVVVESHREFNTVVVFQPWPVSLLNCLVPRELLNLTQTIGKTFEVVSRKDLLVHIYRELKAPGLCFVHKPVLHPEWIVDVEVVVVSVQVNIFGEVAEFVFIAEAHPAGGLDESVEVLGVVQHVEHGDYFFELAINVQGEDLATRQETNLHHFDESLHYIGFLKIKKCGTYKRNAMHKSLYIKGSITWFSNFKIISCRCLMSNVTGRIDSTMRAVVLLVVCLAGLAMATRDTDDFNTNNFATMDIKHRQLVILKLLNHVMEPLMYKDLEDIGRNYKFEDNYERYTKTDVVKDFLKMLKVGFLPRGEIFTLHIDRQLKEVVNMFHMLYYAKDFDTFVKTACWMRLYLNEGMFVYALTVAVRHREDCKGIILPPPYEIYPYYFVRSDVIQKAYLLKMKKGLLDLKLCDFYGIKKTDKDIYIIDENVYDKRVHLNFEDKLRYFTEDIDLNTYYYYFHVDYPFWMKDKFMDKTKTRRFELTVYMYQQILARYYLERLSNGLGRIKDLSWYKPIKKGYWPWLKLHNGIEFPVRFNNYVIARDHNLDVIRLCDEYEKIIREAIIKGFIEINGMRLDLTKSDDMEVLGKLIYGNIEKVDIDRTYVDSYRYLLIVMKAAIGLNTFYSDKYFVVPTILDQYQTALRDPVFYMLQKRIIDLVCLFKLRLPSYTKEDLYFPGVKIDNVSVDKLVTYFDDYLMDMTNAVYLTEDEMKKTKSDMKFFVRKRRLNHQPFKVTFDILSDKSADCVVRVFLGPKKDHMGRLIDININRLNFVELDTFLYKLTTGKNTIIRNSYDMHNLVRDRIMTRDLWKKVESITDMRDFFIKDLRNYHTGFPTRLLLPKGFVGGMHMMLYVIVTPLKLVDNVDMNVLDVNRKDFMYDFRSTVLLDKMPLGFPFDRRIDVGNFFTPNMKFVDVTIFHKKQTCDMKTRWNRYVLKNYNMVDRTPIESDAYFVDTDLNMKVDRNQTVSFRDYHVPPISISSQNRSQLDKMKTLTVVLVITVLGIQISGYLIQVPTAPPVLFRDPIPSQWLHLQKLMIPLLENVCEDSTNPDVRKLAQDFTINMADYLEPNAITNLQKLMSAGLLPKGEIFSEYNPEHMKQLKIVYEAFYSAKNFDVFYKVAAWARQNINCGLYVNAIYMVLQSRKDMAKLSIPAPYEVLPNYFVRKDVLIKATSILSGQEVTPTEGLRDEGNAYYLDANYTGIFYNNDDDSKLAYFREDIGLNSYYYLRKLRLSPFYKGDINERYGENIYQMMKQFSARYNLERYASGFPEIDPIDWNDLPDIPYDPELVYSDGKEFNHRTMPLEFPANDEITLLQTIENNVAAVVGHMRQSGYNKTQILNHLMEILVTGERSYETLARQLLGKDRTNNGHVSVLEHYMTSLRDPMFWKINKKIVDLVDSALKLLPTYSRNELYFPGVEIVNIDVKKMMTAYDYFEFDVTDALKLDDSKSAFNVKIGQPRLNHKPFTVKLNISSLVSKKGLVKIYLGPKLLPGELAAKKNLFTLLDVFEVNLKIGTNVISRTSDDMKHFSSDFASVKTIRKNIEDAEFGLNSLPLKRIEDQIGYPTRLILPKGLSQGLPIQMFVFIAPFTKASVSNSYPSTNTEFNSAILSPGYPLDLVVEDKQLFGLPNALIKYITITQKGENKVENYGGPGVTKQWYGTNTYDPSARPNYSANTRKTFDYNAKKGPSKDDENGVSEYDIAPGDTVNYIEESSKGSFVPKGSNDHNTNVDTVRSLNFMKFDTVVPNNNAEITKLEKKDDNAKQVDKDTYTTVKNEEIDKDVVVPEITEIVPDSENQNQAMLTIPRLLKLSSYDYASSAKSFDYKTKKNQFDKKDYTSKRGDYKKYNSYTPPQEEENLLTTTSAAFIKEDVVNDGEMVEMLLDQPLYQPKNVDYASKRKEPYDYKTKKAQFDKKDYSEKRGDYKKYHSVNKLIDEENRVTTATATLIKEDVINNEQNADLLLEKSSFYPKKDYASKRKEQYDYKAKKAQLDNQDYSAKRGDYFKYRTLPTREEKVSTESVNIMLEPTNDVIARVQLERDDNNVDMLSEIKENNANEENNDNFPKDVVDTKVIEIFDPFRFDVRRRTPTVYDFLFHTFDYDNPENKVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4P5</accession>
    <name>A0A835L4P5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000117">
        <property type="protein sequence ID" value="KAF9415121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4P5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF94">
        <property type="entry name" value="ZINC FINGER PROTEIN CHINMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="405" mass="44624" checksum="46F981339489B009" modified="2021-09-29" version="1">MASRKFIKFLFLVSGRQFKAHKVILAACSKHFQELFDSAPPSHVGACYVILEATTAENMQALLEFMYKGEVHVSQDALSSFLKSGENLQVKGLSMEMSQDAWVKQQTQQNSGDRHQTRIKTSPVSGSGNCEVQESAAPSSHTATFAPIMPQYGMPIHGSGTMGRYAPPAHLPIHAGGHRRPAPPKPSPSQSPHARNYRQSSSSSHCGSVADEPDTRSSPGAGARYEENPPDCTSTHGNPIKNNGYERSASANDDMPERLNNDQGAEDLRIKSENDYQPPGFNNSPPPATSLPNANYHDKPMETSPVPPKPCPDTWPTKLLTSKSGGIATADGKKLKCPYCERLYGYETNLRAHIRQRHQGIRVPCPHCSRTFTRNNTVRRHIAREHRHQVTPHLPNQGPLHNHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4P9</accession>
    <name>A0A835L4P9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="470" mass="51971" checksum="5449F66287A27D04" modified="2021-09-29" version="1">MFRWHGVSAVDPCSTARPRSIDQTSEGCNQAPATRVASASSSCGLFCSLFGASILMDLQTFLVDKFTRWSPPEPKVLKRTKCSITLDWHNVEPFDFIRDQLLYRLEKNEKIPPWVVVYRGGKTSKEIDNLASRHCHKFRLRAAVYDSMRGIGDSDDSSGTSSGEGGGPHTGAARSDDNVEFNLCSCLTRRESVMEIGNNKYLHALRLILRLMCICPWFRSAAVPVAGQKWLASQWSALTWSSTDTDGTSAVCFCMAVQGMLDERPALIGIINSKNGFTPLATAVRKGDINTVRFLLSAGAEIEQRSATGQSALHIAVLNANIPIVQLLLEQGADFEGRDLNDLRVEHYAVDSCSLEMLRYILDRGGDVHVEDSNGWTPLFRALCQNAATEVIEELVVRGSSLELADRAGLPLTSAARLLRDRQGRGRDSVLRLVDTSYPHEKALANFTRLTKKIYNVHSLLKLPSPRNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L502</accession>
    <name>A0A835L502_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_004963</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L502"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="15">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9418153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="350" mass="40446" checksum="538C6D91E435BB7B" modified="2021-09-29" version="1">MQEFKPTEHQHVRYNPLKDEWVLVSPHRCLRPWSGQTEAAPEDQPPDPLNPLLPGATRSSGQRNPAYTSTYVFPNDFPALLERVPDPPPSEHPLFRSSAAKGTCRVMCFHPDSTMTIPLMTVDEILAVINEWVNQLQELGRKYTWVQIFENKGAIMGCSNPHPHCQIWASSYLPNEPRVKERCQKEYFIKFKRPMLLDYLKEEMIKKERVVIQNAEWVALVPYWAVWPYETMLLPINGRPQRMTDLTEEQKRSLAEIMKQLNIKYDNLFKCSFPYSMGFHGAPTGPSAAPGDSPHWLLHAIYLPPLLRSATVKKFMVGYEMLAQSQRDLTPEQAAQRLRECDDVHYKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5B4</accession>
    <name>A0A835L5B4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5B4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="299" mass="32573" checksum="F316133C2969F39B" modified="2021-09-29" version="1">MTGRAEEKYSIMPVSLPKFSNDRIIGGRPTSIQQYPFVVQIFLPDRFLCGGSLLTLRHVLSAAHCFENTLGILKNPKLFTVHVGGTKLYAGTEHQVSAIVLHENYKSKQLAWGYDISVLLLETDVTLSSNVATVNIPEEGASVPDNATVIVVGWGTTNPNSKLPSYILNEVAIKTINWEICEKNYALVEREATFLNLFKTDMMCAGIQGVGGKDACFGDSGGPLLYNGVVVGITSWGVGCAEAQYPGVFTKVSKYTNWIIYTIQHINGTSSVYSIRVTLAIPFLLLMISVTSLWGPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5F3</accession>
    <name>A0A835L5F3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5F3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="553" mass="58402" checksum="31BD324653C82EC1" modified="2021-09-29" version="1">MGSLPDLTERSRPTPVRAAVRTVSDPHRHRTIITPIPVSTIYKKEWPWKKQKTPIRVAGSCIGPRRRDSAASSVGAASVRRLLARQPPKLPKPLVNRFTLLCISSGLCATALLPFTAFAGAEAGAMPLSIMHTAAAVVAPFSPLILQKTGTRLVIAISHTLVCVLLSAHTVETPLPVLLALYGLCGVTLSPMSLALSASATSLAQAAGDEARRKVALRRALRALRAAQDLGLVCGSLLLGFALLIWSEEISKPSTPAPTNITVPRWPPPEEYFLEDDYEERTCGSAGCPDMQTLSGTVLDAYGRMLLVAMWAFLALLSVGMGVYGAPSAPAPPPDARSVFVDPRAILGMPMGLFIGLQQGFIYTSYIKWYGVCVDGWWCAWRSLCGTGVLQALAAGTLSMAAARGRRGALAAGGGAAHASLVLALLRWRAAKTDLALPALAAAAWGACAALWDVLQAGICIGGPGWRGAWSIILAARHSGMAMACIARQLLCVRAQLAGLATALLAALVTHTMLELRLRRGKEPGHKSPKILAKTNSDAAGGACTYVRRRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L613</accession>
    <name>A0A835L613_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_010099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Oligomer composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L613"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000067">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="415"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="601"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="705"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9410967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="988" mass="111364" checksum="5F568B3B59AB548D" modified="2021-09-29" version="1" fragment="single">DREIAAEDSIRVVCRFRPLNDSEEKAGSKFIVKFPSGPDDNCISIGGKVYLFDKVFKPNATQEKVYNEAAKSIVSDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDPGKQGIIPRIVNDIFNHIYAMEENLEFHIKVSYFEIYMDKIRDLLDVSKVNLSVHEDKNRVPFVKGATERFVSSPEEVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKSHIPYRDSKLTRILQESLGGNARTTIVICCSPASFQREAKTVKNVVCVNEELTAEEWKRRYEREKEKVARLKGKVEKLEAELNRWRSGETVRIEEQVNLQEIEAVTPVTSFIEEKPPAAPVPVAVSSAVEDAAMQGKLEALYQQLDDKDEEINQHSQLVEKLKEQMMEQEELIACTRRDYEALQGDMNRIQQENEAAKEEVKEVLQALEELAVNYDQKSQEVDSKSRECDQLSEELQTKQSALASATSELQQLRDLSAHQRKRIAELLTNLLRDLAEIGAAVGGSELDFKLNVDTVGKLEEEFTVARLHISKMKSEVKNIVQRCHSLESANIDANQKIEEYERSLGECRLLISQHEARCASLAESMREAENKKRQLEEAADALREECARLQAAERVQLAAAEQRADSQVRSALEAQLEQLRTAHATQLSALRDELAALQRHHQELKDTYQELTLARQQLQDDYEKLKREEADKSAKLKELIQSVERREQARADLKGLEDTVAKELQTLHNLRKLFARIKKSNNSEEGAEEEGGSLAQKQKISFLENNLEQLTKVHKQLVRDNADLRCEVPKLEKRLRATMERVKALETALKEAKDGAMRDRKRYQFEVDRIKEAVRAKNLARRGPQAQIAKPIRAGGGHLVGGGTPGVVRPAPAQDIKRKSIIVGARGIRSYPVSWHWFHVRVPGRLAATSKFTVTRHGLRQIDMRFDFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6N7</accession>
    <name>A0A835L6N7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6N7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="293" mass="33751" checksum="E923A641EAFC8EFA" modified="2021-09-29" version="1">MPSHHKTVVLPECECSLNNTPSSLPTTLSLATPKPIKDNEIYYEPVEPNSYQNTHFDDQTLSMLNFNINLHSKPSTRSATETNEYLRTAKYEIEKARELPLLLYLDLDLNTAGNNNIQLENLKKMFINFHATEKDLSECINLHIYIFSKSIDKNTAVDSQKITEIQNKCKHTDSIIKESIYQINHTLSQILQRKYEDDTSGVNFSDNIQGPSLYMETISTTDDYTRTQNTESMYEKSTETMQTTTDIDYTLRLPQNTKTAHVTEIVPEKSDMKTNRSTITDEEIPDYKLKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6T3</accession>
    <name>A0A835L6T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22424">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16518">
        <property type="entry name" value="RING-HC_MEX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000012">
        <property type="entry name" value="Mex-3 RNA-binding family member D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047226">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047227">
        <property type="entry name" value="MEX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285:SF7">
        <property type="entry name" value="LD09246P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285">
        <property type="entry name" value="RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="30958" checksum="3C3B29AAF2D093BD" modified="2021-09-29" version="1">MSLFVPGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVGRAKREILSAAEHFSQIRASRKCGAAPPPPAGAPGHVTAQVRVPYRVVGLVVGPKGATIKRIQHTTHTYIVTPSREREPVFEVTGLPESVEAARKEIEAHIALRTGAAGAAGTGVPAQTDSEPLATLYRAGLASLLRPDQEAAFSSAGSCSSGGSSARLGDLLGIWSSTERDEGLGESPSFESPGGGTAGVWAWGPTRPSPAASPARACAVCSERGVAAALVPCGHNLFCLECAQRLAAGGAPCPACSAPAHQAIRIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L751</accession>
    <name>A0A835L751_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L751"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="158" mass="17962" checksum="D7A8D95E6139F12D" modified="2021-09-29" version="1" fragment="single">GTKKGQLTKFNNFVTTLSEFPVQTVTSKQNKELIVRLSKIEGIIHEFDEIQTKIELMTEDPKQLIERDLFEDFYYSSIASAQEVAESYSKANPNQGIDVTSQPSYKSANTWKMGRVQQVYPGSDGVVRVADFKTYRGTERRAVNKVCPLLTNQEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7S7</accession>
    <name>A0A835L7S7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7S7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="98" mass="11110" checksum="5F328959940EEF72" modified="2021-09-29" version="1">MNQLLSDADIQSALMPQELNPAFVPEKNIFKLFQDAPWRAVFPLERMRRDLEVVENTPTPATVSHSLKVYSRIATCISLAIAAIVEIILYVVEFYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8J5</accession>
    <name>A0A835L8J5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8J5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="164" mass="19391" checksum="9695188C8977ACC5" modified="2021-09-29" version="1">MEHEESSNHVKQCIGLAFLPKQDIEDGWLHIMENSFDDEAMTKFNDYFVTQWLEYPDLIWCCHNERHRTTNLAESWNGRFNKIIGKNPSLLLFLQTIGNDTCHFDIKQANFRKRSPINSRKRTSIEIDRQIQKLTKSYENKAISIGDFLINISKSIFRSEHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8L4</accession>
    <name>A0A835L8L4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8L4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="413" mass="46694" checksum="673F0495386CB3BB" modified="2021-09-29" version="1">MTATAPELSKSDFFDFVTSNEVTDAQYKQQMRSVNVFMESPDSRSNPLLSEEPKEQNNNSLLSVSGTQVGPNSGMATATTSTTLQSFDSIWNVDRERDRLDNTMLEDLNKFYWNQDNDINGTHPCADTAISNKLINNTDGQIYTLTVLNHDMTETSSNRYWAKEEDVSMSSPTDIETHNSLDLESILNMNGFPNDFNQDLPKVEGFTYEEGDSESQHADLSTSDLVKVEPYSYEEGEFQSSDKKEESHSSSLLVTPALLESQVEFNNNNNDWKITDQNTESNESLLRSALQGKAFIRYSTIQKNPVKVEVTNDLKRVITTNNNKPDVPSMYQDSKDELLMQISPQNRLNISILLEDPNNSVVSNGENPSSTQSVDDILLSRLDTNYPEDYEKLKKDSNGTWRIYATVLYRGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8M4</accession>
    <name>A0A835L8M4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_001194</name>
        <name evidence="7" type="ORF">HW555_004190</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9633992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8M4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9633992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="16744" checksum="3EA87230175769FE" modified="2021-09-29" version="1">MNKHKIRSLKVCVNSGLRQYSLCCPPQPPRCGCPPQIPGFGRRIVPPSDCRPGPVPPNPCVPKFPGKDGWRKYRSLFFFIGVPLIIVQAIHSLGHELPPKGECRDYEYMRRRTKRFPWGKRGIKSLFHNPHVNHLPGECEPPPLDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Q8</accession>
    <name>A0A835L8Q8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000626</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Q8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0455">Luminescence</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="13">
        <location>
            <begin position="58"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="14">
        <location>
            <begin position="482"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9424233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="568" mass="62933" checksum="DE135B5E6AE22ECE" modified="2021-09-29" version="1">MASAVRSKVLKVLNKQKNGIVSIVVRQKSSNAPEKKVLTSAFKDIPMTSYTANDFVWQNLDRWPDKTATVCAVTGRGYTYAQTHKMSIAFAASLRTKLKLQNDDKIAIVLPNTPEYPVTVLGVLQAGCIASMMNPVYTAEELKRQIELVKCKAVITSKISYANIKQALTELKMNIPVILIDNDDLPEGTIKFAEFAQDFSLDTNCLKAVKRGPKDLAILPFSSGTTGFPKGVVLTHESVVAMNQQIADPEIIAIQETTDTNQAVLPAILPFFHIFGFNVLMMNQMALGCKLVTMPYFKPELFLQTLVQHRAEVLFLVPPMVIFLGKHPAVTPKHLESVYGIVSGAAPISKGDAEAVIQKNKNIVFRQGYGLTETNGAISVGKNDDSNHASVGHILGNSEVKIVDLNTREALGPGEASEIWYRGPNLMTSYYENEEATKEVLTEDGWYKTGDIGRYDENKYLYVTDRLKELIKVKGFQVPPAELEMVLRTHPKILDCAVLGIPDPISGEVPKAFVVPQPGQTLKEEEILEHVNTKVTIFKKIKQVQFVNEIPKNPAGKILRKQLKEMYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L967</accession>
    <name>A0A835L967_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Katanin p80 WD40 repeat-containing subunit B1</fullName>
            <shortName evidence="7">Katanin p80 subunit B1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p80 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KATNB1</name>
        <name evidence="11" type="ORF">HW555_007219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Microtubule organizing center</location>
            <location evidence="7">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Spindle</location>
        </subcellularLocation>
        <text evidence="7">Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat KATNB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L967"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008352">
        <property type="term" value="C:katanin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000462">
        <property type="entry name" value="Katanin p80 WD40 repeat-containing subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03022">
        <property type="entry name" value="Katanin_p80_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026962">
        <property type="entry name" value="KTNB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845">
        <property type="entry name" value="KATANIN P80 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845:SF0">
        <property type="entry name" value="KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="10">
        <location>
            <begin position="628"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="792" mass="88128" checksum="8C037C841928B5D8" modified="2021-09-29" version="1">MESVRRSWKLQEFVAHKANVNCLAMGHKSNQVLATGGDDKKVNLWAIGRQSCLMSLSGHTTPVECVCFGHSEDLVCAGSQTGALKIWDLEAAKLLRTFTGHKGAIKCMDFHPYGDYLTTGSCDSNVKLWDTRKRGCIVTYSSHRLAVNSLQFSPDGQWIASACEDGIVKVWDVRVGKVLQEFMEHTSAVTCVKFHPHEFLLASCGTDKTVNFWDMEKFQLVSKFEKDNTSIRHMVFSDDGATLLGCANDGLHVIGWEPARVFDTVHGHWGQIHDITVAQTQLIAGSFHSTYVVLSVVDLNKVHPFGGPPPVSPPVVRDLSPFQKGHSVRKSFSKEKPPKEVMHRPSLLDEKTAEESTSGTEADEESGAVIPNFNDYTEIFRPSRALTRTPPPATSLSSEDYSISVQEPVEKVEPVVNTCLRDLMLDDPAPLARPLPQPSPPQRQRSEHYSRIPTSTKEHYTVVEKKTESFSRVMDNTKENNAFTTAQSLRDYTSSPLTANSLNRHNSYKETKSTTDLSTTNLRPSNSEISLGPPTLGPRSLSFTRAPTEASRRRVEPIARENVTVSRSVEAPEAEPEPEFVPFTTDRPVGLDLDEFLPRGLAGGNARRGARGGGAEPSEQEVLGVMMRGHDSMMAVLTARQRALQIFHSVRVNKSLRSALESVIALEDTSVILDILNVMAHRPSLWNLDICLLMLPKIYELLQSKYESYMQCGCNALRLIVRNFSSVVRANVSAPVRTLGVDIPREERYSKCMQIHRLLLDVRAFLLKRQTLQGRLGAAFRDLHNLMQQGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L999</accession>
    <name>A0A835L999_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L999"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="9523" checksum="1CE8D04F7834F410" modified="2021-09-29" version="1">MAAIVYIGFSRAANVLSWPKTAAIFLAKRIRCLICVVFGKLTMAYIMDVDCFLSRYDCLFLNYNIFEWPWQETHTHTRNVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9I2</accession>
    <name>A0A835L9I2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000006">
        <property type="entry name" value="Double oxidase: two peroxidase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF134">
        <property type="entry name" value="LD42267P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032690384" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145837" checksum="85D0568F57171066" modified="2021-09-29" version="1">MPLRKRLRRSLLLLAAVLAVQTSAQKIKGDDSIQAVPSDLRRAVSEALALEKRFLLGASDAHNCTSDEDESSRIPCPPSKYRSVSQPLSTPYLPEPALAVHAAAQLTSAADHDYVTSMLAAWGQLIMDDLISTANGNKDCYGATCEYVRSAPTRNIDSCGFERREQMNMATSFLDGSSLYGNSEKELRSLRLYDAGKIDLDSCRKCKDGSPTAPLYKALLSEHNRIAGELYALNPFWDDTTLYLETRRAVAAIIQHITYNEFLPVLLGEVGMAKAELKLTSLGFWRGYSSANRAGVYSELVAVAPIFQAMMNQKLINTTTTLEHLVHTSAQHVSHFPASAQWDLNRARDHGVSSYLRALRMCEPMATIKSFGDFSKMGFSRTQQEMMADMYKNPEDVELMIGGAMEKPASGAVVGSTIACVLALQFANLKKSDRFWYENDLPPSSLSPDQLGAIRKVSLAGTLCAAQDYLSNIQPKAFVREDPYLNAAQHCSQHNRLELSAWRDESGAKAAERLSQDMLATALEKAKQEMADRKKLEYMLWEARGGADPKSPVGTAASFSKANKYALKLANTSLFLEFATNELINTIGTNHRRKRQIFDDSLGFGTTDFVDSLQSVDISGFLGNDQSGPIIEPQCDDKGSCEPDNPFRTYTGYCNNLRNPNLGKGLTTFARLLPPVYEDGVSRPRINSVTGTPLPSPRVVSTVIHPDISNLHTRYTLMTMQFAQFLDHELTMTPIHKGFHESIPDCRSCDSPRTVHPECNPFPVPRGDHYYPEVNVTSGERLCFPFMRSLPGQQQLGPREQVNQNTAFIDASVIYGENPCIVRKLRGFNGRLNATTNPANGRELLPRSDSHPECKAPSGFCFIAGDGRASEQPGLTAIHTIFLREHNRIVEGLRGVNPHWDADQLFEHTRRIVAATFTHVIYNEFLPRLLSWNAVNLYGLKLLPSGYYKEYSPTCNPAIVTEFATAAFRFGHSLLRPHLPRLSPSFQPVEPPILLRDGFFRPDMFMSHPPMVDELMRGLASTPMETLDQFITGEVTNHLFEDRRIPFSGVDLIALNIQRSRDHGIPSYNNYRALCNLKRATTFEDLAREIPDEVIARFKRIYATVDDIDLFPGGMSERPLQGGLVGPTFACIIAIQFRQLRKCDRYWYENDNPAARFTEQQLAEIRKTTMSKLMCDNFDHPGDIQRAAFDLPSNFLNPRVSCASLPQLDLSAWRESSAQGCLIAGRSVAVGESAFPSPCTSCICTVEGAQCASLRITDCAQLHREWPREAVQRDDVCTAQCGASSTAHAPRPARRPHLNFNFPDLSPFVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA95</accession>
    <name>A0A835LA95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7499" checksum="4B9CCBFE35D19285" modified="2021-09-29" version="1">MAKVQFLSILVHFVMWYMRSECTTSLLSCFIVVFNASLFIVLFGKFYKESYTNKEKRRMAKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAL2</accession>
    <name>A0A835LAL2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Solute carrier family 25 member 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAL2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="100"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="203"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34264" checksum="F591F7FC78CB29AD" modified="2021-09-29" version="1">MDFIIGGLAGAGATIFTNPMDVVKTRMQLQGELRARTDATTRYRGIFHALYVIARADGALALQKGLAPAMVLGFTMNSVRLGMYHVAEVNGWTKNKNGDISIEKAMFWSSVSGIMSGVTGNPASVVKTRIQAAAHPSIAVGRQHKYKGMCDGIITIYKTEGFRGFFAGVTATCTRLAIGSAAQLTTFSKAKEELLSHGFFTNTPLGLAFGASAVSGVVVALAICPFDVTTVRLYNQGSSATGAVLYTGVLDCLTKIYRTEGLHGLYKGLGPLYLRIAPHTTLSLVIWDMLNNLLAKSKINTKVVVYQMRFIPQQIHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB25</accession>
    <name>A0A835LB25_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB25"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="762" mass="86812" checksum="B314A0AEC628433B" modified="2021-09-29" version="1">MDVWQMNMPEELSMPVQRALRTMVSGVMLVQCFTVYVYLAAYIVLLYPEERPTLVLPWLLLAAIRKLLCELTSLALGLGTCVLLGPARTPCIKFVVVKFTTIMPAFYMWMLVFSYYHALKVATAFKTFPAVLPPSDNDYGLELAVRRRRTKSLLGEDQLRKKLVASLYGERLCVTNDTYLRPQHDLSSRMVHSTDTSVEEDVPEPDVMKPSTTGWSDSGAYEDWFGSEIIIPRDTDRILEQIVLMLLRVSAYMKKEGTESMIDPEKFSSVVPPLWHRDNIECTINSDDTDTPQNVGSSRGNTASYLRDYPQIFMKKPATEKLQSEPVIAPLKTVRSYGGTDEFKHKTKRNTPTVSHETISISVELEPKPSKKKVTSPDINTEQVSQSNHAPLIEAAKVKSKFDKQEQVKMPFQIRNSEISNKTDNSEQVSEVLPEDNTNKSLNDNLNQSERPNGINNHNNKIDDDEKNTQLLIPSKDSEKSIALITQTETQNRETNLKFLEEYKNMVYNKIMTSNNNSREISDDLIIHEFDELINDRSTLSQILNIECNGEFLVNIVANELKERHLFGSETSHTSSDGDLIDSNSKDLEYPQIFNLDSEENFMFRKVSNENSIDMEISVKTTNEDVNSSNKTCKDEPESNLNWRELATVSLRDDNEIDREMKRESSGIKISSNDTINNLIDKNENLNQGMKIEYFIQGMIIEEIIDKQVFKYNKAKEVPLRIMSNEDNLDPETTTSNTTTVDKGNEVIPKESEQNTSQCNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LE03</accession>
    <name>A0A835LE03_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LE03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="131" mass="15526" checksum="8F9B7C059941EA6E" modified="2021-09-29" version="1" fragment="single">MESNNNLKQRLRSSIGTIKSLRRWWKRGKRRRMAPKIKTILRPGCVICRHGSCVDERKHDRVTRSLTKEINSMEFILIETYRCMPLLGNEEYTVPDWNIHIEWNIGDLHKEMGGNGAYYQTILPMLAIFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFF3</accession>
    <name>A0A835LFF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000458">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="69"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="405"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="526"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="863"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="957" mass="109090" checksum="0E16F85A366AA441" modified="2021-09-29" version="1" fragment="single">VLNLLLSRCLQSRPILNRQPKEKVFCYLTFNIRDKVKFQLIIVKMVVLTSKEKSNMSVADFYAGKSVFITGGTGFLGKVFIEKLLYSCPDIDKIYMLIREKKGQSIRERLTKIVDDPLFNRLKEKRPGDLDKIVLIPGDVTVPGLGISDENEAILIDKVSVVIHSAATVKFNEPLATAWNVNVEGTRMIMALSRRMKRIEIFIHISTAYTNTNRAVVDEVLYPPPADINEVHQYVKNGITEEETEKILNGRPNTYTFTKALTEHLVAENQAYMPTVIVRPSIVGAIKDDPIRGWLANWYGATGLSVFTAKGLNRVIYGQSSHVVDLIPVDYVANLVIVAGAKTYRSNEVTIYNSCSSSCNPITMERLVGLFIDDTVKHNSYVMPLPGWYVYSNYRWLVYLVTIIFQMIPAYLADIGRRLLGKNPRYYKLQSLVAQTQEAVHFFTSHTWEIKSKRTSELFASLSHTDQRIFPCDAKKIDWTDYITDYCSGKTCQIGYVRGHSSVARQNSKENYQSVADYYAGKSLLVTGATGFLGKVYIEKLLYSCKEIDKIYLLVREKKNESINKRIENLLDNPLFTRLKKTDPESFKKLVPISGDIRLPKLGLKPEDEQTLIDNVSVVYHGAATVKFTEPLAIAMNTNFESTKKLLELSQRMKNIEVFLYISTAFTHTQKKVLVETVYPPPAKVEDVYKFIEEYGDDEQATLKFINGQPNTYTFTKSLSEAYLSKHHGNVPAVIIRPSIVSATKQEPIPGWLDNWYGSTPFLMNASEGWLRIVRGNYNSGIDFIPVDFVTNLSIVAAAKAKRTNEVQVFHSTTSADNPTDWSDFKNYFLDEVVRRGKNDLPYPNIVFVESKIALAIGSFLMQTVPAHMLDLWLKITGKEPRYVKILAQVIRLRDSYEHFSSNAWIMRSDRTRQLHASLSPEDQEKFQCDPTQINWPEYLKDYSRGVLKYLKPRKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG41</accession>
    <name>A0A835LG41_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG41"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="412" mass="47535" checksum="C9E8E446201929D5" modified="2021-09-29" version="1">MEELPEISEEFLEPILPCLGLLRNAHILIYVDRKPFWNDKCHLILNVVSVVTYLLSLTMYMGKVFRGELLLDELAYVVSVYVVTVQSILKASVVVFYKKEIRTIILQLGRLWRTEHLTEVQINKKNTLLKRLKFCYAAATLLHVTAIKLFPLLAVFYWINMIGSWQYILAPLLETVTRKFILLQECGLLLPFSCSFPFDPTGNWGRYIGVYIFETYSMFRIVYVYLGTEFLMITLCSHLSTAFMLLQEDLLNNEPGNFEDLKTVIVYHQQLISISKQLDDVFDKVIFINLSSASISICFFGFCAKVAHRAIDMVNNFVAVVTLTLPLFNLCDYGERLREASAGMADSVYHNLWYRGDIQYQKLLWFIMRRSQKPCCMTSLKYSPIGLNTFAAVLSTTWSYFSLASSLYESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1N4</accession>
    <name>A0A835G1N4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
            <ecNumber evidence="9">4.1.3.16</ecNumber>
            <ecNumber evidence="8">4.3.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Dihydrodipicolinate synthase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Probable 2-keto-4-hydroxyglutarate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">HW555_014276</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="31">BAW_Kor-Di-RS1</strain>
            <tissue evidence="31">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the final step in the metabolic pathway of hydroxyproline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.16" evidence="9"/>
    <dbReference type="EC" id="4.3.3.7" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000945">
        <property type="protein sequence ID" value="KAF9404563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1N4"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:(R,S)-4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07714">
        <property type="entry name" value="RNaseJ_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.580:FF:000001">
        <property type="entry name" value="Ribonuclease J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055132">
        <property type="entry name" value="RNase_J_b_CASP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43694">
        <property type="entry name" value="RIBONUCLEASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43694:SF4">
        <property type="entry name" value="RIBONUCLEASE J 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22505">
        <property type="entry name" value="RNase_J_b_CASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="22" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="24" id="KW-0704">Schiff base</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="30">
        <location>
            <begin position="262"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00032879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00033610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00033613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAF9404563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="808" mass="89117" checksum="40A6A685B7759389" modified="2021-09-29" version="1">MVTPFDENGAIDFAKLPQLVNHLLDNHTEGIILAGTTGESPTLTHDEEIELFNEVIRLVDGRVPIICGVGTNDTRDSVEFVKELSAIRGIDAGLAVVPYYNKPNQEGLYQHFKAIAEASDLPIILYNVPGRTVASLDVATSLRLAELDNIIAIKECAGLDALTELIEKAPKDFLVYTGEDSLAFVTKALGGQGVISVASHIFGTEMYEMFQALDQEEVKKAASIQRQVLPKMNALFSVPSPAPVKAVLNHLGVSVGGVRENGKNMYIAEVEDEIFVLDCGLKYPENELLGIDVVIPDFTYLEENIDRVAGIFLTHGHADAIGALPYLLAKVHVPVFGTKLTVELAKLNVEAHAGSKDFDDFHVVDAHTEIDFAHATISFFRTTHTIPDSIGINLKTAEGNIVYTGDFKFDQSAIPMYQTDFGRLAEIGNEGVLALLSDSSNAENPAQVVSELQIADEVFDTIRYWEGRIIVACVASNLQRVQQVLDAAHRSDRKVVLTGQDFQRIINTAIDLDKLKLPSEDLIVPAKDMKKYQADQLVVLETGNMGEPIKSLQKMANGTHRVIKIQDGDLVYITTTPTTAMETAVAKTEDIVYRAGGIVKQISDNMRVSGHANPTDLQLMLNLIKPKYVIPVQGEYRQLAAHADLAHEIGIPYKNIFITGRGDILEYSKQKMTVAGSTTADNIMIDGIGVGDIGNIVLRDRRILSEDGIFVAVVTINRREKRIVSPAKITSRGFVYVKTSKDLMKESSNIVTEIVEKHLESNDFEWSKLKQDIREQLSRYLFEQTKRRPVILPVIMEATQRKGRKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1U1</accession>
    <name>A0A835G1U1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_014247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000929">
        <property type="protein sequence ID" value="KAF9404617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1U1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9404617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="246" mass="28416" checksum="E9D9B6E2A7F64D0E" modified="2021-09-29" version="1">MAETETYQPDEAANLENALLIMQPPSTDTDTNAQQNVTTEVQIDNSSLSLMILEKIGTMEENYKTLKEKTLSWSNLAARDHTIIIRGPLTHPFVNTESALVLMMADYVPTDNHQYDDRFSVYKRTRRLGAGIIFQLTKKMFSVLLVKGRNGKDLLMMEGYTYYQHKILRDGFRWSCTQMGSRSCRGFLHVNHDMFVLRAFTEHTHPPPWKAPKHSRTKDKKSFKMGKKLWNPLPWKISSIQGRANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G246</accession>
    <name>A0A835G246_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="5">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_014093</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000853">
        <property type="protein sequence ID" value="KAF9404921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G246"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002618">
        <property type="entry name" value="PRK02269.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF41">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9404921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="323" mass="35624" checksum="3D723E4DD3588162" modified="2021-09-29" version="1">MSKHYFDPRLKIFSLNSNRPLAEKIAEAVGVELGKSSVTQFSDGEIQVNIEESIRGSHVYIIQSTSSPVNDNLMELLIMIDALKRASAKTINVVMPYYGYARQDRKARAREPITAKLVANMLEKAGATRMLTLDLHAVQIQGFFDIPVDHLMGAPLIADYFLERDIKGDDVVVVSPDHGGVTRARKLAEYLKSPIAIIDKRRPKANVAEVMNIIGHVEGKTCVLIDDMIDTAGTISLAANALKEAGAKEVYASCTHPVLSGPALQRIEDSAIKRLVVTDSIYLSDDRKIEKIDEVSVGELIGDAIKRIHENKPVSPLFETKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2L8</accession>
    <name>A0A835G2L8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_012921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000539">
        <property type="protein sequence ID" value="KAF9406863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2L8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032343781" description="procollagen-proline 4-dioxygenase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="15">
        <location>
            <begin position="416"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9406863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="553" mass="63519" checksum="6C09EBCDC6FC437A" modified="2021-09-29" version="1">MVPNLNLLHVICFALLFDLCVRTHAELFTAIAEVEHLLETHKRIIDDLDFYIDKEEKRLSTLKRHLNLYKMEHEKAMEDIPNYLGNPINAFTLIKRLTTDLDHIEDSIKIGTEYIKNITMNHADVKYPTLEDLAGAAQALTRLQETYHLDVKDLSEGKLNGVVYSTPMSAGDCYELGRALYNEKDYKNARSWMFEALRKYKEEDVSYSFTEADILEYIGFSYYLLGDTRSALEWTHKLLAVDPKHTRAKGNIPHYQKSIAEEELRLRKERRGETGAEPEEEKPATLSEYAKERKAYESLCRGEVDVPLEISKKLTCRYLTENHPFLRLAPIKMEYMYLNPDIVIFHDVISDGEIEIVKRMARPRFKRAVVHDPKTGELVPAHYRISKSAWLRDGEAETIARISRRVSHMTGLSMDSAEELQVVNYGIGGHYEPHYDFARKRENAFAKQGGNRIATVLFYMSDVAQGGATVFTELGLSVFPVKRAAAFWMNLHPSGEGDFATRHAACPVLQGSKWVCNKWLHQGGQELLKPCNLEYQEEGIIRQIPRPVPKSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G360</accession>
    <name>A0A835G360_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G360"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="177" mass="20558" checksum="2F5C9909A6634499" modified="2021-09-29" version="1">MAGIKKMNHLNLKEMWDEDGTAPDIFRAAMSRNRFLLLMRAIRFDDINSRSERNITVDNYFTSIPLADELLAARTTIVGTLRKNKRPKPSSIFGFHKNKVLLSYVPNKKNKKNQVLKRFAPDLELPEEEKPSGICAVCPRRKNRKTKKSCIYCQKFLCTEHSRTLCDMCKARVYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3B5</accession>
    <name>A0A835G3B5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000603">
        <property type="protein sequence ID" value="KAF9406365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3B5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="394"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="682"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="959" mass="108030" checksum="8058AAA23489CF9E" modified="2021-09-29" version="1">MRPPTWFLTLSCNDLNWNDILKAPASDDTVLLGPDETLRNNGRFCILTRKPEEQYVNNYNPQILKLWKGNMDIQPCGNVTAVSYYIAKYTSKHEPQDVGQAVKDAVSKVRSCHGDIGRQLFAVSMAILNHRRVSACECAYRLCHLKLRDSSRKVVFVNTCRPHERYRMLRYDSDDGQTYQNIFDRYIQRPTNLEHLSLAEFAVNYEHTSRFVNDEENGDTEAYEDLEEGTETTRNSIRLLNGSIMKRRRKPAILRTRYYTQTGDREGYFYSYLVAHVPFRNEDDLLADFETCEEAFMEQRNLLRPFHGDSVEQFQFIERELQQVIGQVLALAEPPLLNNFNGQQTENFDVGAIVEGYDPRMADADVDIEGEEVEESSHINITDAEFHHIVRSMNLEQKKIYDEVTKRIRDEVINEANTNVPLKLFVTGGAGSGKSFILKTLVHHIRRCYAPTVDQLLNASFVEVTAPTGVAARLVNGKTLHSAFSLGIEKGRATLQTNVRQQNDSQFIDILNNLRVGELSMEQYEILLERSRVPLAGDFADGNAVQIFPTIKLVNNYNDKMVELMADSVKIYTVNAHDESKEPATYGQKPNHVSIPQDPNCTGGLLSSIKIAIGARVMLRVNLKVSEGLVNGSMGVIKKIEWHGLRRDQLEEGELPKTIFIKFDDESIGKSSKDENGLIPIQPHSIIFQGGAGSGKSFILKTLVHHIRRCYAPTVDQLLNASFVEVTAPTGVAARLVNGKTLHSAFSLGIEKGRATLQTNVRQQNDSQFIDILNNLRVGELSMEQYEILLERSRVPLAGDFADGNAVQIFPTIKLVNNYNDKMVELMADSVKIYTVNAHDESKEPATYGQKPNHVSIPQDPNCTGGLLSSIKIAIGARVMLRVNLKVSEGLVNGSMGVIKKIEWHGLRRDQLEEGELPKTIFIKFDDESIGKSSKDENGLIPIQPHSIIFQVSTLHFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3G9</accession>
    <name>A0A835G3G9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013543</name>
        <name evidence="3" type="ORF">HW555_013784</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000723">
        <property type="protein sequence ID" value="KAF9405519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000665">
        <property type="protein sequence ID" value="KAF9405895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3G9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="39562" checksum="67140DFCF36A021B" modified="2021-09-29" version="1">MSSSSSKLSPLWTNENVILFIELYQGHPIIWDATRKEHKNKNLLADAWRSIHQNMGMMFSIEDLKKKRESLMSTYRLYRKKITDSTRSGSATDDIFKPNWFAYELMDSFLAPIYDKSDTVTINTESMEFPIENNNQDRSFSTESNIQNISTSSAKKRRESEVTDVRAQIKTAVNVLKNLSERPRTEVDEVDLYCQLLAKKIKKFNEQQREVIMHDIDELIYQKRNESYLNMNSPASSSTYSYVRSIPDTVRFTPTPSPSSQMLSYDMSTRDSVRYVTAPSPSPQVMPSPSYHVADDYGDYTVVSPNHSQFQVPGSSTSSTATPKVTIISNDIISQALTFSQIKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3P3</accession>
    <name>A0A835G3P3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_013669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000695">
        <property type="protein sequence ID" value="KAF9405705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3P3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051378">
        <property type="term" value="F:serotonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11497">
        <property type="entry name" value="SLC6sbd_SERT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF279">
        <property type="entry name" value="SODIUM-DEPENDENT SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9405705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="632" mass="69890" checksum="4FCBC4C13E39E818" modified="2021-09-29" version="1" fragment="single">YLKAACLPNVIFYFVVNNELVRPQPLGTRGESPGPERRNGECEPSEMPPSDAPPAPTAPPPDPPATTNNVSTFTSIRNRSYQSQKTRSLVVSLTPPRERETWAKKAEFLLAVVGFAVDLGNVWRFPYICYQNGGGAFLIPYCVMLLFGGMPLFFMELALGQYHRCGCLTLWKRICPALKGVGYAICMIDIYMGMYYNTIIGWAVYYLVASISSINSVLPWTSCNNEWNTPLCSPVTAPQINPNSSTPAKEFFERNVLEQHKSNGLDYMGPIKPSLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYAVLLILLARGVTLPGATEGIRYYLTPEWHKLQNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAHVQNKSIEEVGLEGPGLVFIVYPEAIATMTGSVFWAIIFFLMLITLGLDSTFGGLEAVTTALCDEYPRVLGRHREAFVAGGVYLVDLLNVYGPGLAILFVVFAEAAGVCWVYGVDRFSEDVRTMLGHTPGWFWRACWSYISPVFLLVLFIVSVLAHEEMLGGEYAYPPWSITVGWVMTGTTVSCIPLYILYKFAITPGSFLHRIKTIKRPEVVSIPPSDPTLCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3P9</accession>
    <name>A0A835G3P9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000436">
        <property type="protein sequence ID" value="KAF9407781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48572" checksum="040564D65F3EB5AD" modified="2021-09-29" version="1">MMRGRTRGARNTASAAGAPGAASTGRAASTDGAARPSNGGSAARAGAGACWRCGRAHRAERCRYVNYICDECKQRGHLRVMCRSVKNSGNWVDSRQNYLSDDDSGDIFKIIMMGSKDNKPYYINVTIDSYEIKCEIDTGSRISAINEETYKRQFSHKMIKPDNLMLRSYSGSRIESLGYIEVQVRLRDIEVKSLPLYVIKNGACPLLGRDWLRALKVSQINLHKITDDGFVNRLCAEYPEVFTDKLGTCKRAIQLQLIDEEPVYVRARPEARLVDSVNYVNLIEESFPISFKDVARETEKDSVLCKIKGYVTTRGGKWLQGTIVEQTGPVSYKVDVGRGDCWRRHMDQIIPIHNKNRHSLSRTSIVSASKDGSPNSEVPSVRTETEDTCEDASDEVGEYSHKSNIEAAPEPVTSPPSPPPGASARALRAHNRARLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5J5</accession>
    <name>A0A835G5J5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000456">
        <property type="protein sequence ID" value="KAF9407576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5J5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033094304" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="489" mass="55429" checksum="7B7CF9BA75B17437" modified="2021-09-29" version="1">MSVLWIIVSAYILVVNPIQAARILFYIPTPSISHQVVYRPLAQALASRGHDVTVITADPAFPKGETPTNLTEIDLHDISYGIWREEVMKEARGNSGDTVAQITTIMRTLYVVFDKQLEDEQIQNLLKDKSKQFDLVLLEGVLPQLLVFSHIYKAPAIQISTLGGLFGTYESVGAPTHPLLYPLSTRQKLIDLTLWDKLRELLIFYAIENSWFSLYDLGNSILKKHFGPDVPNISELTDKIDMLFLNVHPMFEGIRPVPPNVVYLHGLHQKPTKELPQDLKTYLDSSKHGVIYVSFGTNVDPALLPPEKIQILVRVFSQLPYDVLWKWSKDDLPGRSPNIRIAKWFPQADLLKHPNVKLFITQGGLQSTDEAITAGVPLIGMPMLGDQYFNVERYVYHGFGIRLDMEALTEDKLKHAINATIEDVSYRRNMERFRTLINDAPQTPLERAVWWTEYVLRHGSAKHLRAPSANISTAPQLCTLTLTTNAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G621</accession>
    <name>A0A835G621_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_012202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000421">
        <property type="protein sequence ID" value="KAF9407940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G621"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9407940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="483" mass="53262" checksum="E7B909EEB3AD4B6D" modified="2021-09-29" version="1">MTIVPAELEDLAWTLSAVWTNMIGQGMMLSYTTSLLPGLQDPGSPIKADLHTASWLASSVGISGIPGFLISSYLMDAYGRKMSHAAAILPGIIGWLCIYLARGIPALMIGRILGGMTAGATVSLGAIVIGEYSDPKYRGVFLNLKTASVCLGGMIVHIVGHFLHWRTVALIALIPYLLSLLVIYTWPESPAWLASRGQFQKSEDSFYWLRGKSEASYNEMEELIKAQMEQRSRPVENKTCSDNIVSYFQRFGQKDFLKPLFIIFMSSIVLETSGRHWFPAYALQIIGEVTGNKSQSFYYTLGIDLIITCSAVSSSILVKVMKRRTLLFSTGFSACVVMMAACIYLFLGAQGIITNDKAWIPICLFVGYFILANLGCTPIPLALLGEVFPLRHRGVGSSAAGIFMSFGVMAGLQVTPYFLIHLKVNGTFAVFAGMMGLSLMVLYFILPETKDRTLQEIEDYFNYGKFKDNRADEDAEVKIKMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6A0</accession>
    <name>A0A835G6A0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000293">
        <property type="protein sequence ID" value="KAF9409861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="20192" checksum="61CFCF4D80E17032" modified="2021-09-29" version="1">MKWMDKLPTVISCCFCCFLRAGTVLIGLFSFYYLMACYNTIQRYHKSSKGLDTIGILFAPNVSHSPGYWDMNAVLSNYSSMAELTAQMTIGVASIMLCSVSVLLLIGACCNMPVFIEIYQWGAIIYSATLSCTFLILALFCFFVHNNCFMAGGVLLVTGYFVIVTNSLRMSLLYLSSNDIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6C0</accession>
    <name>A0A835G6C0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000422">
        <property type="protein sequence ID" value="KAF9407932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6C0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033016133" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15705" checksum="9BA393C2535FE551" modified="2021-09-29" version="1">MKSIIYFSAIFFIFLFSYKETEVSCQGLLPFNNAPIAYADNSSDDDLGLLLSVLLLATRNRGNCCGCCSCGNNIPIPYPIPIPTNNPIITTVSRSSPSVGGDPQEPEEINISTVNNTESESESKASDKTRNTNENDANAASASAAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6C9</accession>
    <name>A0A835G6C9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein CPH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000378">
        <property type="protein sequence ID" value="KAF9408512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6C9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="52543" checksum="988A7D4CEEC40C44" modified="2021-09-29" version="1">MVALADPERQYHNAYVYCFIFHHFIYQNIKYHSSYAALRKPDAVLMIWQALMGVSLDEKVSVFIKIFESKLALSVKPLRTLLLAPAPPHGPFLSTGDLQPTPSCIFADVTKKTTQTTMYKLVVLSCVLALAAAKPSGLGPLGLGFGHLGLGLGAPWGLGAHLAGPVVAPVAAPVLAAPVAHAPAVGVAGPAVVAAPLGGAAHNYRGPVSLAPGQPASILAQDGRPLDTLSVNADRAVHYTARAVDHATAAHGHLLGKRSAPLLGAAWSHVARIDVPALAPAHLAIPAAAHLGWRAPVAPLALGHLGHAGAWGPHCLVYSTIYLPIYIKRLSRHKCISASELRYNTDLSTHNMLKLVVLSCLVAAAAAGALLPYAPLAYSAPFAYAAPVLAPYAPNYRGPLSLAPGQPANILAADGRPLDTLDVNLDRSAHYTAKALDNAGIHLLKKRSAPIIAPISRVAVAAPLVHSYAAPLAYSAPLYSSRLAVAPYNYGYAAAPIAHYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7E2</accession>
    <name>A0A835G7E2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General transcription factor 3C polypeptide 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000321">
        <property type="protein sequence ID" value="KAF9409393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7E2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="150"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="52444" checksum="4EBA548ED3760998" modified="2021-09-29" version="1">MERNNLDRELVGLLFPGIVKNDDKAIACLGGIRNISNVYSSAGRKRLGLSFQPENPFVRKIFGASKRAAGVLMKVKVKKVREGDVIKREVISTTVVGCVKTMFRFESMCDFQYLPVHRETSDGPMTCDLEKYLPCGTDTLDFMLQPAPLFLIPASFTRFERPIGYAYTDKKYPERASPDRDRESVHNKIRSLRGTQVTPYIFNLIDDLPTEPHEFYLKQREQRLECQPTLNQEFEIVKKLLEERPIWSLNLIRYHTKLRLVSLKVIMPCLAVYMKTGPWRSMWVRYGYDPRKDPSSRKYQTLDFRLRHAAGVRSMIMSREDTTDRERQPKRKFTETAPVNEEIAEGTVYFRPGITPTQRHIFYQYCDIQIPEVEEILAAEPPPGYMCHLKRGWLPANTDEICRDHMFRYVKDTLFNSNNPEMKYEAPSGSESESNSEDDTTVNDVDDIEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7Z5</accession>
    <name>A0A835G7Z5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity phosphatase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000395">
        <property type="protein sequence ID" value="KAF9408251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7Z5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity phosphatase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="28412" checksum="B1ABE5058788D1EE" modified="2021-09-29" version="1">MTNDNPVIPFSKNIVCATILYTPRDYETETSSYIGMSRSVTVAVAYIMSVTPLTWREALKVVRAGRAVANPNLGFQRQLQEFETYKLVEERYPSLALADRDLSECRVMLDSYQTMLNQRTICEGKCSMGRQCPTGVCRTGSKRQPRPRKPSVAAGSAEGPGLKRSPSTLSTTSTVSGYRPRSSPAGLYSYTGAPSRPTRSTSGLSVTRVTDPVGGGTAMAVGGTEYSRRRAASAPATPALSPASSPPGSPHRAPHRSRALQRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G808</accession>
    <name>A0A835G808_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G808"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="40265" checksum="C7D7BB4AEF54B74C" modified="2021-09-29" version="1">MVSMQRNVVYNDREPAIFTDCTMDIKLTIVFLVVLALMVSDPVSADFNYNHYRPKLNEVGKDNSVFKCVPGRTTLKMKERKLTLAGEDSNESDDYTRTVARGRPQSVTRPKDETCLICVCSVDGQHEYCKSRSSDTLNECIMIKDINEEFRSLIPFVHSRNLLYRIRRDYLWHNDEIPYSPKDKCFRGHSYYSNSPTANDTDIDLASDVESLLDYNSANTCYYCVCAVDGQSVGCIHRDESFCNFFRVIRSEKRIRDRYTSLLEQDRPTYFRQLSWRLRRTMDNGIYDLINAGGDTLCCSHPDGHRRQIHNEVRNKLRTLKRRIPKENLLGGSMREDYVDFVVNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G810</accession>
    <name>A0A835G810_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G810"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032669961" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="62"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="33989" checksum="D40A2F2938DF34D2" modified="2021-09-29" version="1">MVPILFLLGLTFVAAVPNGIFIPRGTGPRYQHVQDGLGRLHLVDLWQPATDFSARYNPDRDNVYHLFTRKNPSVSQPILPGNEPLLKASNFNPAYRTAVLLHGWFDNATGNFNAVLLAAFLAAEDMNVIVVDWSAGGSNPNYGIAIENTVLSGAAVARFISWVNNVTGADVAKYHIAGFSLGGQQAGIVGRNLGGKAGYVTGLDPAGPGWDGYEHTFKPSDGIYTEVIHTNVGFSGYLEPLAQVDFYPNGGDKMPGCWFIPCNHDRCFYYFAESIRSGGFTGVKCESYEHALVGECHLEETLQMGGIEPKTGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G820</accession>
    <name>A0A835G820_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid synthase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
            <ecNumber evidence="2">1.3.1.39</ecNumber>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
            <ecNumber evidence="4">2.3.1.85</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="61" type="ORF">HW555_011930</name>
    </gene>
    <organism evidence="61 62">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="61" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="61">BAW_Kor-Di-RS1</strain>
            <tissue evidence="61">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="55">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="51">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="44">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="61">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EC" id="1.3.1.39" evidence="2"/>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EC" id="2.3.1.85" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000389">
        <property type="protein sequence ID" value="KAF9408341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="62" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="59">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="60">
        <location>
            <begin position="753"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="58">
        <location>
            <begin position="1874"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="57">
        <location>
            <begin position="753"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="57">
        <location>
            <begin position="894"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="57">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="57">
        <location>
            <position position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00047953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00047961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00048420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00048571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00048650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00048691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00048704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00048935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00049019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00049109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00049171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00049263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00049414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="ARBA" id="ARBA00049422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="ARBA" id="ARBA00049449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="55">
        <source>
            <dbReference type="ARBA" id="ARBA00049521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="56">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="57">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="58">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="59">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="60">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="61">
        <source>
            <dbReference type="EMBL" id="KAF9408341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="62">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2285" mass="253061" checksum="D58A487EDBB480A3" modified="2021-09-29" version="1">MESVNPKELRDTKTGVFVGACFSESEKTWFYEKMQVNGFGITGCSRAMLANRISYWLGVTGPSYTVDSACSSSLYALEHAFRAIRDGHCDAAIVGGSNLCLHPYVSLQFSRLGVLSPDGRCKSFDNSANGYARSEAIVVVFLQKAKDSRRVYAQLLHAKTNCDGYKEQGITYPAGHIQKLLLREFYEECSIPPSILEFVEAHGTGTRVGDPEELLAIDEIFCTGRKDPLLIGSIKSNLGHSEPASGLCSIAKMCIAYSTGYIPPNLNYNVPREGVAALAEKRLSVVTDKTPWGRGMSGVNSFGFGGANAHALLKDVARAKVNNGIPSDDLPRLACVSGRTESAVARILDDLESRTVDAELIRLLHAIHDDDIAGHVVRGFTLLGSTPTKSVTLAREIQYFSGVRRPVWFVYSGMGSQWAGMGKELMRIPVFAAAIEKCHKALEPKGINLTKIITDPDPKIYDNILNSFIGIAAVQIGLTDVLKTIGVEPDYIIGHSVGELGCAYADGCFTAEEMILSAYSRGLASIETPFIKGSMAAVGLSYNQIKSMCPPEIEVACHNGPDSSTISGPADIMKNFVAKLSAQGIFAKEVPCSNIAYHSRYIAEAGPTLLKYLKQVIKNPKARSEKWVSTSVPQALWKDPKAELSSAEYHTNNLLSPVLFEETARLIHSNAITIEIAPHGLLQAILRRSLKKDVINVALTQKGHPDNVQVLFTAFGKLYESGLNPHLANIYPHVPFPVSQGTPMLSHLVEWEHSEDWYVTSYKAQEKMKSGERTVRMSIVDEDCEYMAGHVVDGRNLYPATGYLVLVWETLGMMMGELYTEVSVVFENVRFQRATNIPKEGNLEFIIMIQKGSGNFEIVESGASIVTGRIYAKKNVGQDFRVLPHLPEVTGPSIKHLLTKDFYKELRLRGYQYSGLFRGVLGCNVEGTRGRLTWVNNWVTFMDCMLQMKIIGQDTRGLFVPTRIEKLSIDANMHYNAISKMNPDSNKNSFEIRVYPDVDVIRAGGVEVRGLHATPITKRLPLGVPVLEKNEFIEDILRANIQLVLENIQTYKVKSIELCDEEYKKNDLKPILENIGDMLGDLPLVQAELLLISEEPVEMPSNITVENKKLSGESNTILFIGANLLGRPEILQQAVSTLRDKAFIISREKERPNPKDYSDKYDIVTIQDTGFEYIVLLRKRVGARPAKFVRILASDDTFAWIDKVKEELKEGQKVVLYTQDEHINGLLGLVNCLRKEPGGEIVYGLLISDPSAPPFNPDLEFYEEQLDKDLALNVYQDGQWGTYRHLLLGDLETVRANHAYVNTLTIGDLSSLRWVEGAIRDNHVFKNKEKVLVHVYCAALNFRDVMTAIGRVTVDAVARGRLAQECVQGFEIVGKTVNGSRVMGMIRNRGMANLAEGDKFLLWAIPDEWSFEEAATVPVAYGTVYYAMVMVGQIQRGESILIHAGSGGVGQAAINVALHYGCEVFTTVGTAEKRAFIKKLFPQLKDSHIGNSRDTSFEDMIRRETNGKGVDMVLNSLSDDKLQASVRCLAYRGRFLEIGKFDISNNTPIGMYFFLKETSFHGIMLDYIFDQNHLFRKRLQDLLLSGIENGAVRPLTYCTFESNEVENAFRYMAAGKHIGKVIVKIREEERSNRTSVTKTTFTLVVGGLGGFGLELADWLIMRGGRKILLTSRRGITNGYQSSRLRAWASYGADVQISTHDVTTESGCEEMLKMALSMGPVHAIFNLAVILKDSIFQNQTPETFKTSFAPKALATMHLDKLSRKLCPDLKDFVIFSSVSCGRGNAGQTNYGLSNSVMERICEWRKKLGLPALAVQWGAIGDVGLVADMQDDDVQLEIGGTLQQRISSCLTALDKFMKQDAPIVSSIVVAEKKAGGSGCGNIVDAVAQIMGIKDLKTVSQQVSLAELGMDSMMAVEIKQTLEREFEIFLTAQDIRTLTFARLVELTAQREAAASTSASRPANVEGAVGLRVLMRNFGDENTASEPLVYMPSMVSDGVEGEEAIHVMERVMFMLPGLEGCAAVLEPLCRRLKIKVCVLQLGVEHKNENMDQMVNRLHQTVISRLAPGAPFWLLGYSYGSLLILELASRLEKEGFKGTVFCLDGAPDFLYALLTMTISFKNDFQLQNNLLCHTVDIVAPNNDVTKGLMEKLNEIESYEERVALTIKTSPVQSKYSDKFIANIARASFDRLKTILDFDPKAFRKLQSPVILLRPKENPSFVAVEENYGLDKYTENNVTVHFLEGNHISIIENKDCANIINRVLVENEKQDGKTTDNVVTSIVENAREVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8B2</accession>
    <name>A0A835G8B2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8B2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032285365" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11238" checksum="226C0F3D2B3C94C2" modified="2021-09-29" version="1" fragment="single">IYFHFSGLIIIGLAAEVWSHVEMESEDYFFPLEPMINYCKMADQCQHDFVPICAQDSLGITRMFNDNCDLFEYNCDEKKLARLSSRIYIPENVTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8P9</accession>
    <name>A0A835G8P9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000352">
        <property type="protein sequence ID" value="KAF9408927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1265" mass="147954" checksum="460C83D2C03011D7" modified="2021-09-29" version="1">MLPGLKKKNTGSKTKNNNCQTNSNHHMKSNDLQPSWKSPQNTSNSNFNRICGQRSGNESYHATKRIQNNHYLIKSRQFQSRIDFNIGEYQIGCCLNTRQNNLFTQSLYTPNVITNPSIPLKANKCEPGGCVQYEYDINNHFQRSKLCCAKALESNLVESYNNKYKLDKRAEVYTKSQKSTHVGKSEKQYISVKSDVHTRMGVNNDVKHHRKDELQKQTFLSKCLRSLFKKEKYKNVNQPVLRKNHSDNRLRKARHFRSDLHNDATLLKQAKYDNYFSVSDKTHNSRIENIRSQVNKTHSRATGLTKLLKQCYCTANMQYEIQKQSESQKVINNLTLNSLTVKSAKKSETARKIKSVVEPKKLDRAMRSHTNKYDPKDGNHKEIFRESQSTKTHRRLNQNSQTFGITYPKYNPASILSERSRTFQPKIHYKSREWSPRSNYYVLRCEDSQRSRVKFGTNFRMGIDFSKNKHGNICPGMTTSQRNQLEAAATGDGCGRPRKSSIKSYTDEDYTNYSVNKRGLKSKNTQYKRNKGTRSKSIIAGHDTKDEGSEIGERRNETGAARPTIVLEGKESEMIEATQTDREVKTIMPYSKKKFHKLESRTKLSHHSTNTPDNVNKLKFKGIKRNERIVINKNGDYLVYRHKDFIFNRFGYFDQKIKVSDIKSHEDSIVADRNATQEIIVTYPDGTQDKDGKRGIIRKFLGMYRKPGHQKVTKKRQKDKTPKDIVADRDASQGDFENRLDLIWKALARRPKQQVVMEKPLFEMLVQKDNMSILNKDEILPILKSRRYNTTAPRRTQGDFYIPPENIDENRLKMIRRALGLSQKPRASEKPLFDMMVQRQNMRILNKDEVLPILSTPEALRRRKAGPTSPPRMEIHVDKTTASIINSDEIISQLKKERRREMLRRHRAGLVSMSDGEALLKLHGKQCKCCFCRKYKQQRIIQKFKMKPRRLSPCICGSDICKKDWSKLKMEQSDLHKVKDIPTCVCGSKVCEEEIEKLPKRKLKAARRERVKERIKMKKKLYRQARKQRRKQYRLEDLKRLRRREVEDRRKMKKIKSLKSPPASIMAVESLKDMGAFGFRFIGDTMRSFSRIAKHPKDAMYNAHETMYAVKQDPKTVIKKVQQNYRETGLKPTVARVKQRAIQTSMGKRIKKKMESHPFTNYLVHLTDPDPKTWMKKKRRRRRHKEPVVYEGSLYMNTLRKKPFLRVYRMCPWFYPHCVSLFGLWKQLANVLMFLLAICVWSPCILCFEVCRALTCCCMCTGFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8R9</accession>
    <name>A0A835G8R9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000299">
        <property type="protein sequence ID" value="KAF9409777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8R9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="343" mass="38343" checksum="DE4BA5F34608F704" modified="2021-09-29" version="1">MDHINSTVTGLMDIFQKRMAEFEEKLQGAPVDSPNTSALAADFTVFREFITQAVIGLQQQIELLAKTVDSMEMRGRRNILLLHGVPEGRDEDTAQVVVGVVKERLRMDGFTADDIKRCHRMGRSISSSKSRPILFKLRDVTVRYNIWFEKTKLKNTGITISEFLTKSRHDLFMAARKKFGVTRCWTRDGCVYVLAPDGSRHCISSVAELNTLQLRDTEGSSVQATPKKPITMTRSKRAAANPLSFIATGGISSLARDRVDAIILLITASDCLIQYAANYEFGYRVRDHETGNDFGHQEAKSGDKTHGSYHVLLPDGRLQQVKYSAGPDGFHADISYDHLQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Z0</accession>
    <name>A0A835G8Z0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_010380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000257">
        <property type="protein sequence ID" value="KAF9410581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Z0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000002">
        <property type="entry name" value="Gasp, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF110">
        <property type="entry name" value="LD43683P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032516002" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9410581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="26576" checksum="B669FB8DF3820F5A" modified="2021-09-29" version="1">MAIMKVFIVLTAVTALASAQFKCPNKDGQYEDPVQCDKFYECVDGVATTKLCPDGLVFDPTIRKINKCDQPFNVDCGDRTELQPAKPNSQCPRRNGFFAHPDPSICNVFFNCIEGEATEVKCTAGLHFDEYSGTCVWPDSAGRQGCQVQEKKTKDGFECPVQQQVDAQGQAIAHPKFPHPTDCQRFYVCLNGVEPRDLGCQVGEVYNEESQKCDAPENVRGCEDWYKDAEDAAPAPKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9H9</accession>
    <name>A0A835G9H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000245">
        <property type="protein sequence ID" value="KAF9410806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="92"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="36353" checksum="C64B080FE2BCA649" modified="2021-09-29" version="1">MDNLYMKGELLQVHTKNSEIFEGRFYGMTNDKSKISLYNVKEPKGDPSDGILHYYDSDIRDIVKLKEPDEQKHLKISEKECEEIIKTSKKYIYINQIDKTFHEAMEDLNQYNYIALSTDGANMGRKCKMPVLVLSTPHQIYIFDIHVMEYHAFEAGLKKLLESDTPKKIIHNSRNVSDCLFHKHNVKLNSVFDTQVGDLLITRNKTGRLPEKVKSLAQCLNLYLGLQLSFVDDKFGVVECSARPLPVQMKDSLAKNIAFLHRLSETINEEMLLPFVRGVECFVENIRSLDDFKAWERCGMQNQIPKDFKSAIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAB0</accession>
    <name>A0A835GAB0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000217">
        <property type="protein sequence ID" value="KAF9411669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="444"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="593"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="1487"/>
            <end position="1563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1581" mass="176205" checksum="BB41250559DB02CD" modified="2021-09-29" version="1">MKMKRIVMAADSVHWYMEEVGARVVAKTGIPSDRYHLGKLMLHSLQDDPDFILQIDGATGESETFGSALDRSIRCAVSLTNMGLKKGDVMVLMGPNHIHFSVPHNAALYLDELTKIFETNKPKIIFCQSEKTKDIEEALKMSNLNTKVLTFDEDGQHSSLSDLLKVEDQDSLKNFKPADFDPDETIAYLTSTSGTTGVPKTAMLSHKNFSIGLRYIWTKFSKFPTPTKMVLVTSPAQWLSAGIHYIFSSIMKYTRLQTSATVTPEHFAELVNKYKPTFHATGPNIILTMIAKAKCDFTCFEFIVMGGSAVTQDVVDEVKKVAQTDHVYAMYGMSEACGLAVQPDYYTPPGSYGKPIHGLQLKLVDPNTNEEITEPNVPGEAWFKGPSVFKGYYNNPEVTKATITEDGWLKSGDILYRDQNWNLFFVDRYKLLLKYKNHHVSPVEVEEVIMKHPGVFEVAVTGIPDRECGDLVVAFVVPKPGCSPTAQEIKDLVKESLTDSKQLRGGVIFLEELPLTSTSKISFIDNKMRPLYDAIHWYMAEVGARVVAKTGIPSDRHHLGKLILNCLQDDPDFIFQIDGATGESETNISAAYRSIQCAVALTKMGLKKGDVMVLMGPNHIDFCIPHNAALFLGIMIAPVDVTLVVNELKQVFETNRPKIIFCQNEKAKEIENALQLAGVEAKIVTYNKSDDYTTLAQVLENADDEGVANFKPADFDPEETVAYLPSTSGTTGIPKTAMLTHKNLNILVPYMSSCSKFPTPIRMMFVTSPPQWLSAGFHYLFSAILKYTRLQTSAELTPDHFAELVNKYKPSCLMTSPTMVQTMIAKAKCDFTCFEFIAMGGSAVPHELVEKTKQIAKTDKVIVLYGITELSGLVVQHEYPPPLGSFGKPVGCVDVKIVDPETHDEILEPNVPGEIWFRGPNVFKGYYNKPDATKETLTEDGWFKTGDIFYRDESWNLFFVDRYKSLLKYRNYQVSPVEVEEVIMKHPGVMLVGVTGVPDKESGDLVVACIVAKAWLQSNSTGDQRPGQSLMEKFMCKNEVMAPFLDKLGDRVVASSGIQSDRYHLGKLIFQNVKDNPDLVMQIDGRTGESETNGSVLRRSVQCATVFRKLGLKTGDVIILMGAHHLDQAVPLYAALYLGIATATIDRTLLVGELEATFNNIKPKMIFCESEKVLDVKKAVSQSGLDSKIISFGASHDAMSFSKMMEMCREEIDVDNFKLADFDPEETIAYLVSTSGTTGLPKSAIVTHMNMAISGGYIFTSAKKFPPVQSVLIVAPLQWLSALINYVMGPIFNYWRIQSSAPYTTEHILELIKKYEPKFLISSPPMMATLMKAAAKENCDFSCFDVIYLGGSAVPREMIDELRRLVPKAVVNDVYGMSEVGSLVFSNHSSPIGSSGKPLPHIKYKLVDVDTGEEVKEPYKKGELWIQTPGYFKGYYNNPEPTAEVLTEDKWFKTGDMMYRDEEWNFFFVERIKLLLKYRNHQISPVELEGVIRQHPGVMDVAVTSLSDPDDGDLPVACVVQRPGFDLTADDIKNLVKENLTDTKHLRGGVMFLNELPLTTTTKVHRRNLKTLVAAKVDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAP3</accession>
    <name>A0A835GAP3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000168">
        <property type="protein sequence ID" value="KAF9413174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11417">
        <property type="entry name" value="bHLH_TS_PTF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF112">
        <property type="entry name" value="48 RELATED 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="207" mass="23528" checksum="5B8BE96A60124396" modified="2021-09-29" version="1">MDGPNGIRCSSLDNTSVVPLPVGGSPTSANSSDNYMYDDSSMSDGSLYASDQENLSTPRRRSDYRRLHRRRSSLRCPQQQIQQRQAANLRERRRMQSINDAFEGLRAHIPTLPYEKRLSKVDTLKLAIGYISFLGELVRVDRCSSETMLSGVANSHNKEEQKKVIIRDALCPMERAQTMRPGVTRWRCQDTTPALYVHLLMIDKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB50</accession>
    <name>A0A835GB50_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000260">
        <property type="protein sequence ID" value="KAF9410508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB50"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="238" mass="26886" checksum="5A91BB45B3C88C69" modified="2021-09-29" version="1">MTGVSSVRIINIRVPDVIQYGTKDSITLDCDFVTNNVTGLVVKWFFMDKTTPVYQWIPPQKPQALGILRNKVDLSYKVSHNPYTQHRALHITSPVPELTGNYTCVVSTFLAEDEKTRPMTIFVPETKFDMIQDRLDDKYLNIICSVEGVYPKPELVILAGNRPLNAKSSIKVIDGRYTALTSSVVRIDALPPTVEILCDMQVPLANYYSRKRDIFYRDPPLSSTEIPNLKQVAPDSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBS9</accession>
    <name>A0A835GBS9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032615355" description="Carboxylesterase type B domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="49"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="669" mass="72696" checksum="D4DC0623F2C7E036" modified="2021-09-29" version="1">MYRLWMWCVALALTALWFAPAQAVVGGAPASPPEPDAAVVFTQRHGFSARIEGIKDDKLGYYSFYGIRYAEPPLGPQRFQRPIRRYLAGEMMANRHCYPCPQPDPYQRNRMIGHEDCLCLNVYAPKMPATEEGSPVVFFIHGGNYRTGSTASYGGQHLAQKDTILVTAQYRLGSLGYLSTGQRDAGGNLGLFDLHTAMVWIQDYIQFFGGDPKRVVVMGQGSGGSAASLMAMSPEGRSATGVAALSGAPLSPGTVRPDPAKHAEALAERTGCPKKPAESLLICLRQLPVEKLVQADEDINMDMVDTQRFLEEISGRSGAGARVEGADDLRGLPPIVAESPAEALDKKQKRVPLLTGVTSAETSRAVFGKFNKFLTNQLQTVKDFLKKDLIGGLQNVVNGVEGLIPLAPNVQTVLPVTDYYEGLLKQATNIVDRLSEVAEATGDALFNFPAYQSVQKWSSGGHAFLYSFEHVGNLSKGWHFLPGVALAEKDDGEMEKLKKVQGPSHGDELAYIFEPLGPDGKSMGDEVSSTDARVRDNFVGLIAKFAHGSDKTDDNNTLFGFAANILPKSKDQFLKIGESLTIDKDFRFCQIGLWGNMADRLTGALCKNFLGDLLNLSQLPIDLKVPQQLGGQNNGPLGGLLGNTGTRAPQRPKQPQRTTQAPFRLPFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBU8</accession>
    <name>A0A835GBU8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000237">
        <property type="protein sequence ID" value="KAF9411048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="47225" checksum="0E13169E5890F890" modified="2021-09-29" version="1">MNDSILNYTELAKTEKSHNETHELNIIDNKWIQSSFCVIYTVIFVLGLLGNILVCFVVARNKAMQTVTNLFISNLALSDILLCIFAVPFTPLYTFRGAWSWGSLLCHIMPFAQGCSVYISTLTLMSIAIDRFFVIIYPFRPRMKIETCLIVIVMIWTFSVTVTMPYAIFMTYYDLQIGRFCEETWPSERLRRVFGSVTSVLQFVLPFIVIAFCYTCVSFKLNDRAKAKAASKNSRKEELDKNRKRRTNQMLIAMVTIFGLSWLPLNVINLCNDYYMYAIHLKYYYLIFFIGHVIAMSSTCYNPFIYAWMNENFRKEFKQLIPCIDSSANLRGNIPLDQLGVGPSEKTFNGNTTTDSYLGSSSQRATSFRHKRKPSAAADVEKSGVELNEDLLNVDVKHCHISTSYNLRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDL8</accession>
    <name>A0A835GDL8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_001113</name>
        <name evidence="16" type="ORF">HW555_008826</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000179">
        <property type="protein sequence ID" value="KAF9412741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000892">
        <property type="protein sequence ID" value="KAH9628878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDL8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9412741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9628878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="446" mass="50019" checksum="76F83635E13EA51F" modified="2021-09-29" version="1">MREIINLQVGSCGNQIGGKFWEVISDEHGIDPSGCYHGDSDLQLERINVYYNEASGGKYVPRTILVDLKPATMDAVRSGPFGCLYRPDNFVYGQNGAANNWARGHYTEGVEILESCLDVVRREAEGCDCLQGFQVSHSLGGGTGSGLGTLLVNRIREEYPDRIILTFSVFPSPRVSDCVVEPYNTTLAVNQLVENTDHTFCLDNEALYDICFRTLKLTTPTYGDLNHLICATMSGITTCLRFPGQLNADLRKLAVNMVPFPRLHFYTPGFAPLTSRGAQQYRALTVPELTLQMFDAKNMMVACDPRHGRYLTVATIFRGRMSMKEVDEQLVNIQNKNSTYFVEWIPNNCKIAVCDIPPRGLKMASTFIGNTTAIQSIFKRIAEQFVAMFRRKAFLHWYTGEGMDEMEFTEADSNMNDLVSEYQQYQDATADDEGEFDEEAEGEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDN2</accession>
    <name>A0A835GDN2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000150">
        <property type="protein sequence ID" value="KAF9413820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDN2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032345057" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="412" mass="45693" checksum="A1C3BD8AD51C4A51" modified="2021-09-29" version="1">MCSCLLCALYSPVLCFENTLGSIKDWVNMGSRTKNVLNMLFALMILPLAYCSVQPPVVNPDILTQSKNLGECQACKLFVDSFKKGLERTARGKYEGGDAAWEEEKLKLSYKRSEMRLIDIQEGLCKEGKNSIQCHHMAEKAEEFIETWWAQDPDESADLYNFICIEKMQVCCPKHHFGKDCTPCPGDHDKLCSGNGKCRGDGTRKGNGTCLCDIGYTGDNCDQCMTGYYLSYKDDTKMLCSPCHVSCMGGCRAGSQKDCVACKPGFTFDSDEGCLDINECDDVNKCSKDQFCLNSIGSFTCMSCDKSCDTCHGDGPDMCRKCAKGYSKKGEFCIADREDEDQSEKLTTTRYMTYVGLLIATGILLPRSTSLGSIVGAMVLSYILGAEYYCMINGHTGLVDLRHFDLARMFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDV7</accession>
    <name>A0A835GDV7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="717" mass="86239" checksum="D6BC4A425A59B9AD" modified="2021-09-29" version="1">MDNILDKDIFNENDLDKLSPDYKPRNFILRMQMRRTLAKDSHSHGILKNPNLTRKSIKTKESFAIHKEIVKLRNEFNNIDLKNRVSLKSLEPLKLKSTITNDEPSLLDKSLNLHQADDNFCINELTEEFTELEIRNDNEFKVNPKIKPLKHIKIYRETQCYRKPKNRNSGLLDLPKDINENNQDIFRVECKNKSRSPHNLDHDTNTEPPAMKQDSQINISDKNLDVPVSELQNLLIMMAISSKPNEVEEHHKEVEISNEVNSPKSEILSNVDFNDKRSVSSEGMENILSITPIRVQIDSKETYLMKKYISKWKSYVKNIREKYVSEQRQETLNNFFEKIAKKKMAINQGAEAENKSKILLRDYNTYQHRYKLQKHIIALQKAKLEEQNRLIEELKYNRIVEASRQSVDDMREEVRKTYYEIDRHLKPKIKCLTNELKIPEIEEPSLILHCLKVPQFLQRMEKRAREREEKHAMIRERRRQMEEERIKMKQQAELAKAEMDKEEKMKRIQELREKRRKEKIEHIRKKQWASRLRALIVMADLHYEKTLKAKYGIRPFRILIEMKRDNIEKAKAHYIFQLKNNTFLHWLWHTEDMWMERNFKAENFWRKKLLRKALDAFKRNHHGLVLKKQVADDYYDLYLTQMAFRLFREGINVIRKENEMKWQIAVLYHRSNLLFRTFTCWRTLPALNALKREQEARKARWREKVLQVVPDYTPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEG0</accession>
    <name>A0A835GEG0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032509242" evidence="2">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="351" mass="40438" checksum="5D18CEF9110F9093" modified="2021-09-29" version="1">MARLLFEVLFLMIYFVRSHAMMMRNNALISKMVFDFQKDNSMAATQRPADLSQQQLQPAHHAANQPPHQQHKSQQLLKNPDILSTMQNVLCKNFPTIPCGMIVEDETLRNLIERSIQQLKYKKLSMEQTTAVPGYHLTLFPSINSEDLSNFLQVSGHGYFNKNKSEQSRAKIHRKRVAKDNAEQPTEKDAKKKSKSKLDNTRSTLYNGRKKIRKFYPHKIKYKDKTKARKEFVDYSEEKLSMSVEVPDLNGGGAGVDTGRKQSHNVNYKVEPADPPVWRIDYMKHGEPSLNVFGYEPDRLKEKLVKTGRNVFVSENVLEQAARKDVLHPDVYIKKNYIRKNALDMNSGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEH8</accession>
    <name>A0A835GEH8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_006720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000103">
        <property type="protein sequence ID" value="KAF9415750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEH8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="46859" checksum="00BD065FF036E459" modified="2021-09-29" version="1">MLKNILQKLENPKRPLLGPNVKVLEFWGLLLPKNVFKKYFYLLMHLMVTIFTATEYIDVWFVKSDLNLLLNNLKITMLATISVIKVSTFLSWQKYWIDIIEYVTRADLNQRKTEDKEKLDLLKAFTQYCRKITYLYWSLMYTTVVIVMVQPIFKYVSSETYRLNVKNGTETYLQVVSSWVPFNKNKMVGYLAASAYQSYAAIYGGGWITSFDTNAMVIMVFFRAELELLRIDCKDIFGTETAPVEHGIALKRLKECHRRHVELVKYARLFDSCLSPIMLLYMFVCSVMLCVTAYQITIETSPMQRFLTTEYLVFGIAQLFIYCWHSNDVLYASADLMLGPYESTWWSRGVQYRKSLYLLVAQFNKSIVFSAGPFTKLTVATFISILKGAYSYYTLLSQSQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEN6</accession>
    <name>A0A835GEN6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000132">
        <property type="protein sequence ID" value="KAF9414487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEN6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032271998" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="31"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="28290" checksum="9C73E9BB32ECE115" modified="2021-09-29" version="1">MQLSVGIVVILVSVSCVITIPVPDNADLARIVNGETVDITEIPYQAALRRRVLSGWAHNCGAVIITNRGLLTAAHCVETFVSQPSLLRVVVGTSSRLTGGKTYDVSVIYSHESFSATTLEHDIALLGTSKIMDFSQSVAPVSIASEHYVLPDGTGAVVSGFGTTSYEGSSSEVLMAARVSIVSQSVCARAYLRIATIGEGMVCAKGSNPPRDACQGDSGGPLVVRNVLVGIVSWGEGCANTNYPGVYTRVSEYNPWIKQKLELLRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEP7</accession>
    <name>A0A835GEP7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000154">
        <property type="protein sequence ID" value="KAF9413580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEP7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="354" mass="39634" checksum="214C8D6D2F6023AD" modified="2021-09-29" version="1">MPIGLCGFDNPHRDQKTEEVRRHIGQGVKIKMDDAGNILIRRYSKSSVFVKSTAATSNEETAIGQDIVKLPGYALEQEKIFKLFDMKKFQSNVNRELRRSYPDRRRLETQCLIQRLMDIKNRPRIPIPDEDPYSIASSNANGSGSSGSSGGYGHNGHNGHNNNGHGVVAATREQLMMQMGQRRGDKPPKLPPRENGYGPADIPKPDYDDIEGHDGRVPTQFPRGKSDKGKDNKKYDDPYYCGLRARVPNFVKTNGAKVLPTMTERLTLKEAPVPSKRYSVAHAHPGPFPPHMAPFAHAPMPPQALWHARSYESGIDGEQHYDPYALYGRLPMPGRGFPPPPAPHARHMFIGEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GER8</accession>
    <name>A0A835GER8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GER8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13588" checksum="9DC887AA454EAAB3" modified="2021-09-29" version="1">MHPMCHRTVPTIADATACLPVQVPKGTDSLKMPKSKGILKELTRRKLKLYKRRPFALLLQSQLQNTPRKLTGQRWSVDDQNAKLDIIDGYQDHGNQGRTMEPATHALLFMAIGIRKKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFH5</accession>
    <name>A0A835GFH5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Larval cuticle protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_010773</name>
        <name evidence="5" type="ORF">HW555_007271</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000946">
        <property type="protein sequence ID" value="KAH9627621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032532162" description="Larval cuticle protein 1-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9627621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12192" checksum="0A3746CA5C340403" modified="2021-09-29" version="1">MKSMIIVALALVALAAAHPVDDTEATIVRSATNQDPSGAFDFGFETSNGIKVNEQGQLKEVVDEENKPHSVVVVRGTYSYVNSEGNNEVIEYIADENGYRAEGPSVPKVPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHM8</accession>
    <name>A0A835GHM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_011768</name>
        <name evidence="3" type="ORF">HW555_005587</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000468">
        <property type="protein sequence ID" value="KAH9636932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000043">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9636932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="133" mass="15019" checksum="5B17A93472D19A00" modified="2021-09-29" version="1">MAPVKAPKKALKSMEKLVEKPINKSKKMKKKNYQSFSIYLYKLLRTVTKDNLGISRKSMLIMNNFVNDMLEKIAEEAGRLVAHSKKTTMSSREIQAAVKLIIPGELATHANIEAMKAISMYHKSHERDAAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHN1</accession>
    <name>A0A835GHN1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="37">Trifunctional enzyme subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="36">1.1.1.211</ecNumber>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="38">Monolysocardiolipin acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="39">TP-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="ORF">HW555_006542</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="45">BAW_Kor-Di-RS1</strain>
            <tissue evidence="45">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:31180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:31188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:31160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31195"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:31196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31199"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
            <dbReference type="ChEBI" id="CHEBI:62614"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:31168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43676"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:43677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43672"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83581"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:43673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43680"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:43681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:16107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:20726"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:136757"/>
            <dbReference type="ChEBI" id="CHEBI:136758"/>
            <dbReference type="EC" id="1.1.1.211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:52657"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="35">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="42">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="45">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.211" evidence="36"/>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHN1"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000011">
        <property type="entry name" value="Fatty acid oxidation complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000002">
        <property type="entry name" value="Trifunctional enzyme subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012803">
        <property type="entry name" value="Fa_ox_alpha_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02441">
        <property type="entry name" value="fa_ox_alpha_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="44">
        <location>
            <begin position="364"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="43">
        <location>
            <begin position="544"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="For hydroxyacyl-coenzyme A dehydrogenase activity" evidence="40">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="41">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="41">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Important for hydroxyacyl-coenzyme A dehydrogenase activity" evidence="41">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00052989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00062153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00066806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00068347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00077617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00083277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EMBL" id="KAF9415910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="763" mass="82155" checksum="245BD4AE82733B19" modified="2021-09-29" version="1">MSNSKIFNALKILRTRKDLKYLTGLHSRNYAAAAGSLVHTKCKIVNGVYVVTLDSPNTKVNSLNTAVMDEVTTVLNEIESNPSIQAAVLISGKPGCFIAGADITMLEACNTKDEFVTLSKKGHVIFHRIEKSRKPIIAAIQGSCLGGGLETALACHYRIAVKDPKTGFGLPEVMLGLLPGGGGTQRMPVLTSVPTTLDLALTGKTVKADKAKKLGIVDLLVAPLGPGLGKPEDNTMRYLETVAIQVASDIANGKMKVDRSKKGLVQKITASVMQWDMVKNMIFNKAKEQVMKASRGLYPAPLKILDVVRTGVDKGPTAGYEAEAQGFGELAVTPQSKGLIGLFRGQTECKKNRFGKSQVDIKSIGVLGAGLMGAGIVQVSINKGYHVVMKDATNAGLFRGVGQIQTGLANSVKRKRITGLQRDKYLANLLPTLEYEKMSKCDCVIEAVFEDINIKHKVIKELEAVIPKHAILATNTSAIPITKIAAGSSRPDKVIGMHYFSPVDKMQLLEIIRHPGTSDDTAAAAVGVGLRQGKVVITVGDGPGFYTTRILSTMLSEAVRLLQEGVDPKTLDSLTKNFGFPVGAVTLADEVGIDVGSHIAVDLAKAFGDRFSGGNLEVMPDFVKAGFLGRKSGKGFYVYEKGSKNKEVNQEAVNILKQRYPLEARGANTPEDQQLRMVSRFVNEAVLSLEEKILHSPLEGDVGAVFGLGFPPFTGGPFRWVDQFGADKLVKKMEEFHGLYGAPFKPAQTLVDMARDGKKFYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIZ1</accession>
    <name>A0A835GIZ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">trypsin</fullName>
            <ecNumber evidence="8">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIZ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032846248" description="trypsin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="31"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="29876" checksum="51D0F610459618E8" modified="2021-09-29" version="1">MRTRLARTMRAIILLAILGSALAVPRNPSRIVGGTVTHIERYPYMANMQYSFFGTFFTQSCGGSLLTTTSVLSAAHCFYEDFEWQWRVVLGTSFRSQGGSVHSIQRIIMHPQYIDEILNNDVAIVRLNVPAVYSDSIRPARIPGPEYSLADGSIVAHVGWGRQWTNGPLSEQLLHVHVNVINQEVCAARYAYLKTQPGYEEWPDINEGMLCAGKLDVGGKDACQGDSGGPLAHHGDFIVGVTSWGFGCGHSFYPGVSARVSHYADWIVANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJJ3</accession>
    <name>A0A835GJJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Angiomotin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_016586</name>
        <name evidence="8" type="ORF">HF086_016587</name>
        <name evidence="4" type="ORF">HW555_005194</name>
        <name evidence="5" type="ORF">HW555_005195</name>
        <name evidence="6" type="ORF">HW555_005196</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000605">
        <property type="protein sequence ID" value="KAH9634498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000605">
        <property type="protein sequence ID" value="KAH9634499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJJ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024646">
        <property type="entry name" value="Angiomotin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12240">
        <property type="entry name" value="Angiomotin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Angiomotin C-terminal" evidence="3">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9634498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9634499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="13741" checksum="AC8E02B1EBD86001" modified="2021-09-29" version="1">MHAPTVSTEGPAARAGVAAAGVGPPRAHRAQAARPAREGAAGAQVQCMLLLFQPKGLQRALASLQQASDRREHTERKLRAQLEKELQALRYNACSYCFNRRACSARWRRCSRRRTAASTPSASCAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK47</accession>
    <name>A0A835GK47_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK47"/>
    <dbReference type="OrthoDB" id="6496929at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF14">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032959692" description="Protein sleepless" evidence="9">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15506" checksum="6ED9FB91B9B74023" modified="2021-09-29" version="1">MSSSYFIFIVLCGLFHYGSTIMCYECNSAINSLCLEAKLPDSLKKNCSDHDRGVTHTLCRKIVQHVDYGVNGRLPESRVIRSCGWDESKFKGQCYHRAGYGGRQEVCSCLTDYCNGAKGTTASTTFLTTAIMFIGSIICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK62</accession>
    <name>A0A835GK62_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK62"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="480" mass="54392" checksum="B7F93D1581BC3D2E" modified="2021-09-29" version="1">MEACSDNNNDNLVVNDRSYTIFKDNFNRKLLEYDGQHQGSLKKAWTSERIAEVINGIKKARMSKTCGQRMTPMDYYWTKKYDIVTIDNQEHLVFKRRTDTVPVVRILPREDYFVTLLELHKTCGHGGRDKMLSNIKHLKYYIPKKAVEILLSLCPVCESKRNLSSGGVAQNIRSSDSESSGQVDVKKPVVQTHHSAIDGQANLKISRDIITKNVINQNKKNSTVITTKPQTNPVQFLLLKDVTTELGKRDSSSGGSQATPNEIPLKKQKLTTCACSEILTESVTKNVLEKLSKEDNDPDKQFFLGLLNDFKAIHDENKLDAKSDIINVIRYYKNKSLNRAINEEAQTGDTKANNSHYADCFNKMNERYSVTCNDSLVVPKCIRNLCKPASPSRKVEIEINPLALKDEPSTLVTKESGKACLGTCRCCIQQQSQQELRDKEIVVVKTEPQDDGNRTYLLQSDEIKIEDRDQTNTESEEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM2</accession>
    <name>A0A835GLM2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032821538" evidence="7">
        <location>
            <begin position="20"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="324"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="539" mass="61583" checksum="EAB2C162B5EA0099" modified="2021-09-29" version="1">MAALPAFLALFLCVSLASGYTLLRDDENEIIWPSEYHFKGEKLNFKSSLKENFEMWYNGELNRSRIDFYDGTVKKWYYGDTGYEYVKHPFTTEEVTNEEVCLVRYSEDEQIDFLPDVSSFTYTGQTMTMYDKVVDVWTSTEPYDDKAIRESTLYVFKTDAGVDIPVQHVTKSYNLDLGEVISHVITNFYDFSDTVDEEELTVDDDEECEGVSLGKNFHKDLKFFHPDIPSELDQAFDLYTNHHGKHYQDTEHQVRKTIFESNWRMVEEHNRKNLGFKLKLNEFSDKTPEELNYLTGTYLSTHQDPVMKPFPHNLAEIDELAEDLPETFDLRMEGAVTPVKNQGHCGSCWAFCTTAAVEGAVARANGERLVDLSEQSLVDCAWGYDNMGCSGGTLDGAMKYVMTHGIPTEEEYGLYEANDGLCRIQNMTNPYKIRGFAQVTPRNPNALKVALNKYGPVTVAIHASSLMQHYATGLFYDFSCDDTYPNHGVTVIGYGTRDGEDYWIVKNSWGENWGEDGFILMSAKNNNCFVLDSPYYPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLQ9</accession>
    <name>A0A835GLQ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor Adf-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="28569" checksum="347E8D5A27766FE3" modified="2021-09-29" version="1">MEAKNDMFTKVGDRKDIVDFVKEVEKYPCLYNKTLPEYANKVHNRRAWSNIAKKSNTSIPDCRDKWRKIRISFMRSLKQQASDKPPMRPYYLTEELRFLYPFISIRPKTDKSPKEILPDDHSDDKMEYENSITTEKQETSDNDSSNYEEDLKEQNREISRVSFNDNTMSNVTKIRTENAVEPKRFNGNNNYKYIEGNPRKMFLLSMLPDVESLTEPEMRIFRREVISIIDKIIRSRSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLV4</accession>
    <name>A0A835GLV4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLV4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="250" mass="28642" checksum="2388A28A591B5379" modified="2021-09-29" version="1">MDFKNRNKRNDAVRDIASVFNIASSEIERKLKNLSSHYFREKRKYEESKRSGSGRDDVQLPKWFAYKALSFLNDKNAPVPTLNSLTPSSSQDNITSQTTLLSTRTSRKRNIEREPEVDEALQLLREITSNARQRDDAAIFADYISSKLRKMDHYTMCTVQHQIQNIVYEAEMRMGSMNFDTNNTTQPLRYQNVLPGYFTGRPTTSAMSPSPSTSRSVQSDYEMQNSPDVNTSDSLLQVLENNLTENSVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM06</accession>
    <name>A0A835GM06_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM06"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9419601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="548" mass="64202" checksum="1AF96B756D9E0DD0" modified="2021-09-29" version="1">MATKKGKGPLFEGGLCRCCGNMKKCRVLNIEYESLGQKEIYSDMIMDCFGLLLSHLDGVPSERLICATCVTRIRDALSFRRQVLRCEEAFLQMKIYDAQSDESKIESQWHSKASIEVVVKAEPVPMEAQSDDENCEDTLADTPDPDLKQDKVSDEDDEPLIKRHATQPIEETDRTLEINTPVVQPLKSETQMPKTQVAPSLPVVQTQKLPMAKVQQIMRERDSSYMTETNVLTIVEYSFVCPFKCRHNHLLCYYCGELYSDPDLLRQHTQNIHHPKKFKVTEHKKMVKIDLTRIDCRLCTTKIDDLETFKKHISEVHKKKYYFKYKDSVLPFKLSRDEMKCAICNVLFPYFHALNKHMNEHFSNYVCETCGLGFVDKSRFVMHQQRHEEGDFPCPDCGKVFKALYNRDLHIDRVHRKKGRVYCPKCDVKLMSYPQKLKHLVELMIDINLLRHFKAIISFSRYECQCCGQKFFTRFALNNHMPTHTGERNFKCKVCEKCYPRLKTLKDHMRIHTNDRRYRCHVCGQAFIQNCSLKGHMKSQHPEYEMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMH1</accession>
    <name>A0A835GMH1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_002816</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMH1"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="94"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9421104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="298" mass="33305" checksum="21C4B669CCFD5DCB" modified="2021-09-29" version="1">MSSDTPRVLSIQSHVVHGYVGNKSAVFPLQVLGFEVDSINTVQFSTHTGYKHIKGTSLKNEELDELIDGLTMNDVDYYTHFLTGYSRSPDSLKKIVEILKKLKEKNPNLNYVCDPVMGDNGRMYVPEDILPVYRDVVVPLADVITPNQFEAELITGLKMNNLEDALKIIEALHKKGPKTVVLSSTELGDETYMIAIASTGGVQYQINIPKLDAAFTGTGDLFASLFLAWWHKTNNDLKLTLENTISTLQIIVKDTYEKARVHQPTGKISPKLRELRIIQNKNFIENPKVTIVATKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMK2</accession>
    <name>A0A835GMK2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMK2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="368" mass="42101" checksum="B597080919311F8B" modified="2021-09-29" version="1" fragment="single">RHRSPTFSREEVKALFNIVDKYKTIIFNKSTTSAACRAREVAWMKIAKTFNRQGISHVRSADCLKIKWDNMKKRARMAMSKNLMDLSHNEFDETTSQMVAMMCEVENNTGNVEDPVESSEDLNVSENENHKESNDRPWNGNEDKDSNDSSTDGANERFVSRSINFSPDECNLLLQCVRQEKNIVFSKTNTASFNKMKNRAWERFSNMRKMVKSSNIKNYFKEFAKKSHSLEDSGSKIKSEPLFECRSSMDADNDSDLDDQMDADNKSSNSDVNTTLDPLSTVLNTDIGLNSISEFENKEILKRKRIENLIQADAAERESKARETALKLRAARLEAIAAEMKFPSAHPALSYTAEETRAQHYLHQYHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMV7</accession>
    <name>A0A835GMV7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome RNA helicase MTR4</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Superkiller viralicidic activity 2-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">TRAMP-like complex helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HW555_002613</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">BAW_Kor-Di-RS1</strain>
            <tissue evidence="28">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000004">
        <property type="entry name" value="Superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="132"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="359"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="772"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF9421398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="996" mass="112721" checksum="7A06F6E1339A15E0" modified="2021-09-29" version="1">MADVNSLFDCFDESAPDDASIQLPDIKKEKSEPVADNPTESTSLKRLHEEVEVIEQTTKKQKADEDDTELTSDINLDLLNARIVIHTLETHEGCTHEVAIPPNHEYAPLMPITGEPAKQYSFILDPFQKEAILCIDNLQSVLVSAHTSAGKTVVAEYAIALSLKNKQRVIYTTPIKALSNQKYREFSEEFHDVGLITGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVIFDEIHYMRDKERGVVWEETLILLPDNVHYVFLSATIPNARQFAEWVCRLHSQPCHVVYTEFRPTPLQHYIFPAGGDGIHLVVDEKGIFKEDNFNTAMAVLSNAGDAAKGDQRGRRGGPRGANQTNIFNIVKMIMERNFAPVIIFSFSKKDCEAYAMQMAKLDFNTIEEKKLVDEVFNNAMDVLSEEDRKLPQVENVIPLLRRGIGIHHGGLLPILKETIEILFGLGLIKISSGEYIQMSGRAGRRGLDDKGIVILMIDEKVTPAIVKGMVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFFQFQNQAAIPDLIDKVKQKQKEYNSLTISDEHSIASYCNIRSQLDLLGAQFRSFITKPEYLKPFLQPGRLVKVKTEKHEYDWGIIVNFRHNTSKGKKGEENPLNSESVILVDILLHVKKPSEDDTDSRVPCPPGEVGDVEVVPVLHTLIYQISSLRVYYPKDLRPKDNRKSVLKTIGEVKKRFPEGPPLLNPIKDMKITESVFKECVDRIKNLEERLYAHPLHNDKSRGALTAAYERKQELHEELTLAKAELKTAKSILQMDELKKRKRVLRRMGYCTAADVIELKGRIACELSSADELLLTELIFNGVFNTLTSEQSAALVSCFVCDENSSQASATGEELRGVLRQLQEYARRIAKVSQDAKMEIDEDEYVGKFKCTLMDVVLTWAKGASFLQICKMTDVFEGSIIRCMRRLEEVLRQLCQAAKNIGNTDLENKFSEAIKLLKRDIVFAASLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN02</accession>
    <name>A0A835GN02_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-MWFE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase MWFE subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_003421</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN02"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9420360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="8452" checksum="C510D31F3402C9FA" modified="2021-09-29" version="1" fragment="single">MWYEILPSAFIITAALGLPGWGLYHIHNLVLGNFNKIITVLQHYRRTLDSRWDRHIYQRDLRLTGNPYKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN41</accession>
    <name>A0A835GN41_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN41"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48930" checksum="DB569771922FAA4B" modified="2021-09-29" version="1" fragment="single">MKGSKSKSIDVEEYTAQDLPSLRRKRTMSYNRLVKALEIGTVALSDSSKRDLFLSYYRDIKTIAHNFEHAHLIILDILDDPEDVDNKMQERFDDMYYQTLDFPVQHWDFVLVYHILSKIDPEVRQSLEEKYSDVEIPSFDQVKSFLRAKSEALIHCARGCDVSISTHPAATVLAASLDIKQTTQPYKCAYCDESHSITSCPTFLKKSVDERINVAHEKKWCYNCLKSSHQLKDCKSIFTCRTCKRKHHTLLHRERPQPQEPNPTVSALISKSHLNTTVLLATAIVQVRDASGRMQSFRALFDTGSQSNFITESAVKSLGFTPAKVDTKVSGLGEAMAPISGDVTCSVGTSTRVYYKLNMHVIKKICGDQPIAQLNTSGWSHIKSLTLADPGFDIPGPIDLLLAADVFVESILNQRIKGGYNQPTAFNSIYGWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN73</accession>
    <name>A0A835GN73_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN73"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="29060" checksum="948A33EFB6DD2881" modified="2021-09-29" version="1">MDFVGDDQQLSEALRQCMAGMRAPLDLSDVEAKKAAMRSLDNPSPLAEDVEIKPDLLSIDLGLQRVNISLDYAELVTMKDLKNEGPKSADFRKRISQAAYKMPREYLGADRNMHRELILRIMQQTVYSVQQRLEEVEPLIAMYEKDARYRLAYIFARLDEWKDEMRTMYYAVRHRKLKNTKIYIYYYERLLRHNIDVTYTIEYVIHMHSEYMQRMEELLPSQERQKLLKAKKAKAAVTAATTVVPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GND6</accession>
    <name>A0A835GND6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GND6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10518" checksum="AF8CF96F0854EFA9" modified="2021-09-29" version="1">MVNNYKRKSNRNSWDEASMKNAIEKVAAGEMGLNKASHQFLPSTSKASQPSPPVLSTEDLQPLVSRDNQPSTSRANEAANDVENISASTTPSIEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNW2</accession>
    <name>A0A835GNW2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNW2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="283" mass="32048" checksum="5BBAE711716CA54B" modified="2021-09-29" version="1">MQQRRGSYADAELSLRKMAAICLAWRPSKLHTVKGTKLVLHLASVSTGKAVRNFCKRTVQHTCARTCSLSRVSAEDSSVVNMNGQENVVLCAAACVLLCSLLKKKRRKKPRCWVRPLLQRRNEETNKFLEEIKIDPLSGFKNFTRISCQDFELLVNATSPFIAKQDTNYRKCVPVSIRLAITLRYLATGDSFASLMFLFKVSKELIARIVPETCKALISVLKENIKILFHHYDVKDLNNHYRGPENLKPVLDSIDEFEYGEGIGVVTYFPVPIIASYYPDAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP20</accession>
    <name>A0A835GP20_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026104">
        <property type="entry name" value="ZNF_C2HC_dom_1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649:SF1">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="486" mass="53210" checksum="03C8AF4835C5BA18" modified="2021-09-29" version="1">MPTVLRKWDSASNVIVNSIDSRQPAGGAQRCVGADLTPPLRKNHGTARFQQKQMQEREMKIASLYEAQQARALDRVRHSPSNVGHASPPLPPPTHQPGKVRQMFEERRTKAGIDKSYPLQPIHNTDRPAARKPLPNGYNKVAPSKVTVERKVNKTHTINSHTVKRQQVHKTENIVNGSGDLNHNHEPDMNSVKHILPQSNGEVILPNTDELDKVDNNYLLENETFPEALAPTPTPRSPDPPAVTKKPPPRRSPAQRSSPAKTKPQPSPPAAAPARRTTSDNAVPESNKARGAMQRAVNPVVTRRQPLSSGSVGGAAASSARRGAASAAPASAASGAACTVCGRHFAPDRIDKHQEICRKAHAKKRKPFDALKHRLAGTEAEPFINKLRKAPANPASSTKVNKNLNNNWRQKHEEFIQAIRAAKQVQAHLSAGGKLSDLPPPPPSENPDYVPCPHCGRRFNQQAAERHIPKCANYQFNKPKPAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP89</accession>
    <name>A0A835GP89_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="93"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="73"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="57"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
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    <sequence length="4026" mass="470361" checksum="F3736C93D7825DAE" modified="2021-09-29" version="1">MLELPLAFLNLQFEVTGIPKPCDANLTNATVIILWTEGYLKILNNGHNNMCRCCASEGAFKDIKSTYHWMGEEEIYADMLKECFDISLNVSEHGEDGGICEVCITQLRNAINFKKQVQHTEEQFKKHLQNKAMFRPHIVKVEVVAGDEDSDGDNIGSGDDTFSGAEFEVPIKTENDDPKPKKRSKGMAASTRSKQSKTTTDDGETSTKRMDEDGPKRRKRKKNSEESATPERVEHRVNLTAILQYSNASPFRDKTIRGFSCLYCSKPFPDIQKLREHTAQQSEKDKINTIIDYKLSYNPIKVDITNLHCTVCNLEMKDLNDLKDHLVVVHNKTIYKNIKDIILPFRLEDGHNFTCVICSLVHISFKNLYHHMSSHYRNYCCKKCGEGYITIAALRKHGKTHAQGIFPCDFCDKSYTSMTKKRNHEKGVHTGGWLRNKCPHCPEVFVSYYDRSEHLVKAHNQTPIIYPCNACNKIYKKKFELNRHIKHHHLQQRSYLCDKCNAKFFSKRGLSDHLSRHVGGVVFSCDVCGKSFSRARTLKEHIKIHEDDKRFQCEICHKTFMQKCSLKSHVRLHQDDLDIFKEFDDVKHLIDNRELTLKQIAAESVTGATKNLRKRAVKEEADDEALSQLVYREKHVPEMKKQWHNLTTLLMCSNATPFKDRNDAGFICAYCFKTYPTPEILRAHTHADHDKEKSSYKAGSCKASFVAFLDIVDLKCTLCDQPMDSLQTLTEHLVSIHEKKYYLGITDYFQPFKLTNEQQINCCLCDEVFHNMKLLMQHMNVHYRNFICTTCGAGFVNSFRLNRHETTHLKKKASFPCRHCDQVFAAESKKKAHVNTEHKGIAGDSVCQICKARFKNYYQKTRHMMQVHNVEGIKCDQCEKKFNLKSNLMLHMRSVHLKERPYECSVCSMGFFIKRHMLGHYMATHTNERKFKCEVCGKAYATQNSKRKHMKKNHGISKNMVVANIEKRSNATELATLILIRTMEQQVNTDTETKRNKTPISLRKNQKRCQVELFKQRYNVQEILLSSNATPIRKYNVGFVCCFCDKKFLEANDLKIHIITNHDESEKIDFMKGHGLQAFLVKLDVTDLQCNLCDTEMNTLEDLIYHLIDEHNTPMFTDIKSYILPFKFEDSTFKCTLCELIFEKFKVLQEHMYTHYDNFVCDTCGSGFVNEKMLIIHSDSHKVGVFSCGHCSEEFETPVKKKYHEKTVHLTSLNKCGYCNEKFMWYNQKCAHIEEVHGIKINKPKECNACDKVFSSDWRLQVHIRRDHLHERRFKCTECEMEFFAKESLNQHMVQHSDVKSVPCRVCFKTFKLKKVLREHMRIHNNDRRFKCDICDQAFIQKVSWKGHMRSKHGISETLNNSFLFFVGVQRNVNAKIEKDCDKKLKRSKSEQLEDTKLNELVKQRSNIRLILQCSNATPIRCRGGIGYACCFCGDQFPDPAELKKHTLQGHDDKTKLQFMEGKMMFSFLVKLDITNLKCNICEAKFDKLEQFVDHLIKEHDKKIFTDIKSHVLPFKFDDDVLRCLYCQNVFNKFKNLQQHMNVHCRNYICKYCDAGFVNKHILACHTEGHKIGTFQCDLCSKVFDTLRKKKSHEKSVHIHANLLCKCGYCYQKFTNYRKRDIHLVKVHGVQLKAVKCHACDKTFDSKSALTVHTKRDHLMERPYNCTQCDMKFFGSNELKLHMVKHTGVREFKCTVCFKSYGRKKTLTEHMRIHNDDRRFKCEHCGQAFVQKCSWKGHMKNRHDTINKEQESRETTTNYEQQIKIEDVRSKAEITDVNTKKTRKQRTKRCLQKYLDNLKIILECSNATMILRHGDKGYLCCYCSEAFEKPKDLKEHTLSQHKNEDTFYGNVVANGPSTFLVKLDITNLICLLCNESIDSLENLFSHLKDIHQKIFHADIKDQIFPFKFNSDQLSCCICKNNVVFVTVRALHEHMHKHYRYFICDVCDAGFINNITLSRHRVTHTKGSYKCRHCPSVFNNILKRRNHEMRTHTNSGKPYVCHFCNQSFKEYIAKEMHLSKAHDVAPKKYDCTACDRTFPTHGHLKVHIRRFHLMEKSCKCTECDQAFFRDGDLKAHILTHTGAKDFKCEICSKFFARKSSLNEHMRIHNNDKRFKCNLCGQAFVQKSGAQQKTHVEMEFNKNNERNETEAKAKRRQLLKHKKTIKDILLYSNATPIKKFEGNRYACCYCKYQFVNPADLKTHTLNSHNDVAEANFIKNMSMSIYVVKLDITGLKCNICYEKLNTLEEFADHQKLHQKIISKEHLSHILPFKFDSETLKCIICSSSFDNFRNLIKHMHVHYRNYICPICDAGFVNRNALLFHTVTHEAGTFICDYCPKIYTTHVKKRMHEKAAHSNVDKINKCAFCEETFKDYAKKRVHLASVHGIVASATACQACDKVLTSRRSLSIHMRRVHLLEKPHRCEICDKTFYSTSCLKNHMVRHTGSKEFQCNICQKTFGRKKTLNAHLKIHDEDNRVTCEHCGQKFAQKYTLKCHIKSKHANAQPATIKIINIKTEKYEDDPNTKKDIKSPKKVNKTLFQTTEIGKHKMNAIELMRWSNATPIRNHGDMGYSCAYCSNQYQDPAELKTHTLETHKDVTAAYFIQNLSLYQYIVKMDITDLKCTICQIEIDTTEDLLQHLKDKHDKNVFLDIKNHIVPFKFNSKTLNCFICKNIFYKFKRLLVHMNIHYRNYICQVCDVGFVNHISLKYHAATHKKGVFQCEQCPTEFETLIKLRLHEKKTHGNKKRIDKCGYCSKTFDDYRKKETHLRLAHGKEQNLKCTACEKVFKATKHLNVHVKRDHLLERHNPCKMCDMKFFSKSELKDHMAKHSNVKAHKCEVCSKSFTRAKCLKEHLRIHNNDRRFKCEICSEAFVQKCSWRGQRRRTRIIKIEKATKPTVELKFVSKLRINPDSMLVKGADTEILKNKVNLENILLNSNANPIRCKDSLGYGCSFCPKQFQDTTALKKHFLQEHNNDKLIKYMSAKLFQQVIKLDITYLNCALCDKDITHLDDLITHLKKDHNKPMCLDVKSQILPFRFDSPQLKCAICSTEFVAFKLLQEHMNMHFGNYICEICGAGFVTDRLRMSHVRRHDSGEYKCKQCDKTFTNETRRREHEKRTHLGISKRNKCNYCSERFVDYWKKVNHMVKEHGMPPVILKCSACDRTFSNQRALSTHTRKDHLLERRHKCTECDMRFFYKSSLQKHMAKHTGLRQFKCDVCLKAYGRKNTLREHMRIHANDRRFACTHCGQATIHETSPIIFEEEEKNISLDRKLNFASFVSIRPVGKKAIPWVREQQKKIAEERRLTELDWQFDNIKTILRCSNATPVRCRVGTRFACSYCLDQFQNPTELRNHSIQDHINDKPEFFNARSLSRHIVYLDITGLQCKICDQSIESLEQLMDHLKGVHDELVYKQIKNQIVPFKYDGRKVLCGVCAIDIGEYNDFQDHMSEHYRNYVCGFCDSGFVIRSTDPESVLIEIEVDTSVFITEDEEQNVSPLTEVDKHRENIRTILLATNATPIGRYGSLGYTCCYCPEVFSAPQELKKHTIEEHGQENISSYMNNYTMLNYIVKLDITNLRCEMCMTPFEELHKIVDHLASVHEKFFHKDISNHIVPFRFDSDMLRCVECSFAYNNFKILLEHMNSHYSNHICDFCKAGFVNRRMLQAHMYRHKTGVFTCGVCAKVFDTRIKMKVHERMVHMYLKKRPKCTICEQKFNDFESMIQHETESHGFQREFHCETCKKVKKKRIIEIKSDDSKIPIHLKKKTEVDKHIHNIRTILCHSNATPIGKYAGIGYVCSFCTQEYETPAELKTHTINNHKDARSSFMEDRPLYNFIVKLDITNLKCDICQADVDTLEHIVDHLQTVHNKFFHLGLKSYVLPFRFDNNTSVSSSSCVICNNNYNNFKVLLEHMNSHYRNYICEICDSGFVNRKTLLTHTYRHRTGVFNCSYCQKVFDTRVKLKQHEKAVHICMNKRNKCGYCGEKFTDYLKKNFHEVLVHGAKPRVLKCQACDKTFDNQRSLTFHTKTYHLLEKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPB2</accession>
    <name>A0A835GPB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000353">
        <property type="entry name" value="WW domain-containing oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="409" mass="46652" checksum="28F3E0A73F30D0F9" modified="2021-09-29" version="1">MHHVDSDSEDELPSGWEQKSTEDGNVYFINTLTNKTQWTHPRTGRKKEIPKELPYGWTKTFDDENKAVYVQKDTGTKTYVDPRLAFATDAKEHVHDFRQRFDASSTAYQTAKSLARHGCSVIFANRNMESTKEAIQKILQETKASEDDLKAVHLDLCSFESVRKCATAVKSIRLDMLILNAGIFGVPYTETEDNIEMTCQVNHLSHLYLTILLEPLLKKGSRVIFVSSESHRFASLKNVFNLQNLAFPKESYSSMMAYNNSKLYNVISAKVLSEEWKNRDIYVNSLHPGNMVFTNLSKSWWLFRLAFALVRPFTKSLQQAAATTVYAATAPELRGVTGLYFNNCFYCEESAMARDKNIAHEIFALSLKMIAARVGTDDLKKYMNKFNTTQSLSKEQNSNVDEKQSDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPE0</accession>
    <name>A0A835GPE0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear respiratory factor 1 NLS/DNA-binding dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPE0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="8">
        <location>
            <begin position="83"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="513" mass="55117" checksum="7781C796D31B91E9" modified="2021-09-29" version="1">MVLEFSPQDEQDTDYTMNSAVSTESMDMEGEDMSQVDGCGLSGASDDDDECASSPTGSTYDDSADLIKNAMSDEVTKQLAAAGPVGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQFGLGGGPQAPAPPQEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARTEDEKQKMSWTHALRQIVINCYKYHGREDLLPAFTEDDEKGPPTQPISACMPNAASNSSSSSTSAGRNNQQQQAVLTSQQVCIDQMTLADVDMSQYAPAVLQTITNPDGTVSLIQVDPSNSIITLPDGTTAQVIHSGEGGAGIQALDGDGAVAVDLNAVAEATLNHDGQIILTGEDGHVEAYVLCSIMEQNGEGLETISMGGGVTQVMLQGGEGAQVLQVLSLKDATVLTKAMQVKAERDAVVTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPV9</accession>
    <name>A0A835GPV9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPV9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF114">
        <property type="entry name" value="IP04436P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032595543" description="UDP-glycosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="115557" checksum="FFFACF3AD4AF4365" modified="2021-09-29" version="1">MKFNSIIVLFSALFSEVLGLNILGVFPYQGKSHFFVFAPYLKEIARRGHNLTVISYFPLKEPVDNYHDISLAGKTKILEDVFPIYRSYWSIIQISFFLTNSGQENCITLLDDENVQNLWKTKQKFDLVLVELFNSDCALGLAHKLGAPVVGLTSHVLMPWHYEDYGIHYNPSYVPVLFLEGGTKPTLYQRIERSIFHLYFVYLHKLTCRRNNQKTLAQYFDDVPPLDDLAKNVNMLLLYTNYVLSGPGLYPPNVREVGGYHVTKPQELPQDLKKFIEESEHGVIYISFGSMLRATSTPRDKLEAIIDAVSEIPQRIIWKWEEKTLPGNPKNIFISNWLPQNEILAHPKVLAFYSHCGMLGTTEAIHYGVPIIAMPVFGDQPSNAAAVEESGLGVQIHIKELTKETLLEKLRIVLNPEFRKRAKELSKVWHDRPQSPMDTAIYWTEYAARTANYTFRTPANSPPLPKLSVCCRRPQSRHRPAPYFAHYSRHAPLAAFKYSIMKPSVLISILSLLVLTDYACSLNILGIFPYQGKSHFIVFRVYLRELAKRGHNVTVISHFPEQDPPANYHDISLAGSTKPIEDEGPFQTSYLILLAVSWFLAHSGVQNCDTMLANDQVQSLIKEKPKFDVIVVEQFNSDCALGVAHKFDAPVVGIMSHILMPYHYQRLGIPYNPAYVPFHFLEGGTKPTLYQRVERTIFDFYFRTLYKYYTQRSNQNSLAKYFDDIPPLDDLARDMKFLLLYHNFVLTGSRLFPSNVIEVGGFHVIDAKPLTGDLKKFVDEAEHGVIYISFGSVVKATTMPADKVQDVLNVMKQLPQRFIWKWEDKTLLVDKNKLYTKNWLPQVDILAHPKTLAFLSHAGNGGTTEAIHYGVPMVAMPIVGDQPANAAAVEESGLGVTLQVRDLNQENLLNAFKKVLDPKFRQRVKEVSKAWHDRPISPMDTAVYWTEFAAKHPNFTFRTAAADVPFYQYINLDVAAVLITIFILNIVALRILINKCRSKKKVTTKTEKKKAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRN1</accession>
    <name>A0A835GRN1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRN1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="27421" checksum="04FBCC71D047B960" modified="2021-09-29" version="1">MGCSIHYITPEMHHANGQVERYVRTLLNMLRVETYNKKSKWSEELWRLQLVLNVTKQKTTQASPLNLLIGIEGTTPVIKTLVRDVALDISSSDRRSLRELDRQRAAERLKDNQIRQDEDVNKTRRAPHVFQKDDLAFVIKYTQSKGKLDPGMRGPYRVTRVLENGRYELKLVAGAYGKVTYAAAQFMVPWKGEWTPDECAAFFAHPSDVTTTEVQSTPASDDEEVGAKIPAEDARVSGEAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRR1</accession>
    <name>A0A835GRR1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_001289</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRR1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="14">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="15">
        <location>
            <begin position="293"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="13">
        <location>
            <begin position="487"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="14">
        <location>
            <begin position="701"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="15">
        <location>
            <begin position="949"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="13">
        <location>
            <begin position="1069"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9423220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="132259" checksum="0993EBEA1F08260E" modified="2021-09-29" version="1">MSQLEKMKVNPDLAMERAKCNFNIMEVTHILDGGEDNTLRRKKIEDIALNSGASKDSFPEEHMSPKEKYENAVRKSCLYADLVKNHFAHLTGLETFGINSGVIRRTADAFFKEVSPFLLHMGMFVPTIMGQCTSEQMSYWLPRAMDMQIIGTYAQTELGHGTFIRGLETTATYDPETEEFVLHSPTLSSYKWWAGGLGNTANYCIVVAQLYTKGECHGTHPFIVQIRDEDTHMPLPGITVGEIGPKMGFNTADNGFLGFDHYRIPREHMMMKNAQVLKDGTYVKVARHGKLTYGTMVFVRVILVNEAAFNLAKACTIAVRYSAIRRQSRPNPDAPEPQILDYATQQHKLFITIATAHALQLSSTWLWQSFSAVLREMKDGNTDKLPEFHALSSCLKAVSTSDAAYLIEQCRHACGGHGYMISSGIPHLYNFVSATRTYEGDYTVLLLQTARFLVKAYEQAEANQPLTPTVSYLKLAFSRKEPWDSSPAGIVRSFQALAAGKLSSCVKNMRKRMRSGLSEVDAWESSTIQLVSAAEAHCRAVISDAYRSEIVRLTANSSPNVKIVMEQLSTLYLYYWALERTGDLLLYTSMSEKDIVELQLAYEEQLQKIRPNAVGIVEAFDLRDELLHSTLGSYDGQAYERLMDEALRSPMNKEPVNQAYYNSVNSIVASPQTTHSIFVIVKMSAKVNEDLLTERKKCDFNVEELTNYLDGGAQATENRRKLEDKVLSTKGLLDEVPEEYLSHKEKYENAVRKAVVYYKAMKEAENPNMTEEERANATYRSLLHAAVFKDNSPFSLHLAMFIPAILGQADEEQKKYWMKRASKMEIIGTYAQTELGHGTFIRGLETTATYDPHTEEFVLHSPTLTAYKWWPGSLAHTANYCVVMAHLYINGKSCGIQPFIVQLRDEETHQPLPGIKLGEIGAKLGFNTVNNGFLGFDQHRIPRNRMLMKNAQILDYVTQQHKLFIGIASSHAFSLTAKWLTRMYQKVTADLEKGNLDELPELHAIACCLKAVTTSDTSVLVERSRTSCGGHGSLVKAWELAQSGKPLSPTMSYLSEKISHKQKWENSVDGIVKGFQRVAYGKVQSAVNSIRKYVRRGLAPEDAWNMSSVQLVAASEAHCRAFILSTYKSEVERTASTLSAPLKKVLNHLVELYAIYWALERVGDLLLIYPVITVPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSI5</accession>
    <name>A0A835GSI5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="263" mass="30227" checksum="B1662F78E4B32822" modified="2021-09-29" version="1" fragment="single">MEHCISSEGNTIIEQNKFVNDCPDCSELPQDPVCGIRPDGKGFRVRTFQSECELEKYNCEVKENFTITDYFICSNNPNAEGKNEEHKKEELEIMLETNEDSVNETNIDRELPTMLKEDDVNNTNAFKNVVIVRGSVLNGRNINKSIANFFKSTLNQGIPIRSVLPGYNESTRKRMIKIFGPVKLYEPRVVKPKIVHEDYYHQPTLSSCFHKCPTKCPDIYNPVCARHGLQSRQPSVMFLNHCYMDVAQCKVFWEDKTETARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSK2</accession>
    <name>A0A835GSK2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSK2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="225"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="45354" checksum="0DB59D817298E740" modified="2021-09-29" version="1">MQCPHLAFSEVGVCARALHALMGGSGSAGGGRASRVLRLLLLFVLALAAVEYLFGSILDASPLRTYLNSDKTQLLTGNRGAMLNLMKPPTVNTTNTMPVYKNQSIHNNQTMGNKVMIEQSQSTQSSILLNKLMDSLNNETTDMSNTNKNDSSSLPMCELPTDLGPIQANKTDMDLATIEKKYPEVQFGGRYSPPNCTARHKVAIIVPFRKMLKLLTKIDCKMFPGDKPFNRAKLMNVGYVESQRLEPNFTCFIFHDIDLLPTDTRNLYSCTTQPRHLSAAVDVFKYKLPYKTLFGGVSAMTNEQLRKVNGYSNKYWGWGGEDDDMSDRLKINNYHIARYPMSIARYEMLTHKKQRPNPKRYQLLSQSKSFVKDGLSNLDYKVKQVINYHLYTHILANIDEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSQ4</accession>
    <name>A0A835GSQ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSQ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="5"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="478" mass="53957" checksum="155925A9B2F467C7" modified="2021-09-29" version="1" fragment="single">FKVEGYPVFVWFHGGDFVRGSPNSVNPFQLVLKQRVIFVSVAYRLNIFGFFSTLDNEASGNFGLHDQVASLHWVKNNIESFGGDPENVCIIGHDAGAVSVTLHLISSYSAGLFHKAIAMSGNALSPESVNIARKEIVTVDKVAVAFSCFRKPTYQLLDCLRRVPDKALLDIAGPVAEWKPIVDGGFSNITSPFLPELPSKLFKDEIFSPVPLLAGYTNMEDGLLLEKDESGDSGISQREFDSMREEIILADITVDNSSCFTNQHHIQDAVAFFYKPIPHTTNETVLRKLFVDFYTDKTHGATTYQLARHICPHAPVYLYRFDLKPFSDIANEGLPEWIGVPHNFDLIYTFGMPYLALPEDLSKWDYRDKSISEIIMRMWSNFAWYSNPTNSGVIIDWQTYELERPGYLIIDRANFTMSTPATINYKAFEFWTDFYPKVVEIGTKCCKEITDDSGTISIFSSKIVHSILILYFSLILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSV0</accession>
    <name>A0A835GSV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="243" mass="26802" checksum="605703057DF0349F" modified="2021-09-29" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTSEGVVLAVEKRITSPLMEPTTIEKIVEVDRHIACAVSGLMADSRTLVERARVECQNHWFVYNERMSVESCAQAVSNLAIQFGDSDDDSGTAMSRPFGVAVMFAGIDEKGPQLFHMDPSGTFVQYDAKAIGSGSEGAQQSLKEVYHKSMTLKEAIKSALTILKQVMEEKLSENNVEVVTMTPGSMFHMFTREQLAEVIKDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTU0</accession>
    <name>A0A835GTU0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000022">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="28715" checksum="EBFAE5F1121D19CD" modified="2021-09-29" version="1">MARRYDTRTTIFSPEGRLYQVEYAMEAISHAGTCLGILATDGILLAAERRNTNKLLDEVFFSEKIYKLNDDMVCSVAGITSDANVLTNELRLIAQRYLLQYGESIPCEQLVSWLCDVKQAYTQYGGKRPFGVSILYMGWDKHYGYQLYQSDPSGNYGGWKATCIGNNSAAAVSSLKQEYKENETTLAEAQALAIKVLSKTLDMTKLTPEKVEMATLTRKDNKTVIRVLTSTEVEKLIADFEKSEAEAEAAKKQPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTZ7</accession>
    <name>A0A835GTZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Semaphorin-1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000212</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000016">
        <property type="entry name" value="Putative Semaphorin-6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="15">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9424911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="649" mass="72083" checksum="C58DFB03A08BE00B" modified="2021-09-29" version="1">MSNVVYNLSLTDLTEQRRLVWYSPENDVKMCVVKGKDEESCQNYIRVLVSLGPGRLLVCGTNSFRPFCREYSVQRDSYHMEREKSGQAVCPYDPEHNSTAVYADGELYSGTVADFSGMEPIIYREPLQTEPYDSMTLNAPDFVNSLVHGNFVYFFFRETAVEYINCGKAVYSRVARVCRDDRGGPHRFKQRWTSFLKSRLNCSVAGDFPFYFNEIQSTTELIEGVYGGLNAQLIYGTFTTPPNKPRPGTCHNDSRQLPDQTLNFIKTHALMDESVPAFFGEPIVIRTSFHYRFTQIAVDPQVKTPGGKAYDVLFIGTDNGKIIKAINAVSYDSNKRAVPVVIEELQAFAAGSPVRALRVARAGRDAARLIAVSDRQVLSLRLHRCSSDKISSCSECVALQDPYCAWDKQAGRCRAFSHGVSRWLDENSFYQSVSTGSHAACPHSKDAGAVGGLSSGLYDDARGETKGEVINIVQDKDGKGGGGGNEGPEVLAADPPPAAYSVETLALAVAAGALAALGTGFAAGYICGRRCKKDDDDNMPYPDTEYEYFEQRQNINRIQAEPKLLQQVEEVTYAEPVLAPQPKPASPRATLRKHPPYHPHHETLFQFQPDAYRRDNFGTLRSHQVNGDGYRRGNDNGFSTTRSVKKVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUF9</accession>
    <name>A0A835GUF9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Brain-specific angiogenesis inhibitor 1-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="IMD" evidence="5">
        <location>
            <begin position="48"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="375"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138547" checksum="5F9BFD2368B07F6E" modified="2021-09-29" version="1">MSYSHTFAANRCSILEGRIPAPKTIYGLSPHLQLHMNGPYLFSHLCGNNILDKFNPGARQMITAGKAYLKALHGAAAASRLYVDAVGKLGRQAQQGTWGGCADIGTALMKVVEVYREIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQSEQKRFLQQHKLRSESYSKAAATIKKQRKKKPNVTKVGSAMDKEMKNMQILEEEKTKLDAFCEQSLKNAMTQERRRYGFVLERQCSLAKHWLAYHTAGAAAYNSGLDEWLEVSRTREFLPPNVEAMFVSRMRQVSFWADEDVYASPRVGDDDDRASVGSALRKTRSVDASCLDVRSIGDLGSPTQGLSRAKSDFNLQASSNNDDQGTDTRAATRPSSLAPPTCTTRDPPLARALYAYAAAGDNQLSFQQGDVLALLGERTKGWQYGENLRSHHAGWFPLAYTEPIPFDEAGRNSPARWSCVQTPSEAPPPAPMAHAQTTPSATVHTHSHPPARMFGDTVTAHHVTKGRLGSGSPGLPPTLPAPSPSALSTSASATFHASTPAPGATTAIKNSTSSASFTTHAVIETRSFGPQTLPMRSQVAQNKAGPAKTVVSAVGAVGNVSLHSSNDSGFSNEPPPQPDVDYSDEEAQRLRVPISKSAQQNNDNRAYLLKTQSLKRGPKPNNTANGYLTDDQQLMLRNMLDMDKDSQKVKRTKSFWKFGRTTAEEIMEGMSLWQHRDIVDTVPEYKKKLFEKMKKELRPAPDIPKQASPEKTPPTENGQPPRPKETIDRKDVKAVNGIRQAKSLGSIQSEERVEKSRKAMEYQHTQTMNKKSMSEKSIIEEKHEDFAPRNESRHSDLTNTSTIKTNFENSFYNDENGEGFVMKTVKRREILQKYDNDSSSDVNSVASSTDPYDCIIVDDHMKSRKQQEMDRRRQTQMIEEDVKKRKENAYMPEFEEIEVTPIKPHVRATLSSEKTKNSPHERSPPKTMEFKTFKDNSKEIKTFSASSETLTYKDNEQHTDRYGMPIERNNNDVRNEDIYNGHDEGTLKYKKRSSNDDKNHQTNNVENGKNHKKEYPQAEVRNQRKDGRPYESNREPRIDYSLDRRQTRKEFTDTKGREQKKNKANRSYDDSSLPYNGRREERYYESNISYFSDQERRSSRYDYETDSKKAEKSKIRQEEARLEARRFIDRRSEGPYSESDDQKFNEALKQQRPQLLPRTKLLKRPSEGSEMLPEEGHTFGPWYDLWGRETAVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVJ2</accession>
    <name>A0A835GVJ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="11">HMG-CoA synthase</shortName>
            <ecNumber evidence="3 11">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="function">
        <text evidence="8">This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3 11"/>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVJ2"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="456" mass="50788" checksum="0923009CE1B978FF" modified="2021-09-29" version="1">MGGRVENVGILAMELYFPSQYVDQTELEKFDEVSTGKYTVGLGQLKMGFCSDREDINSICMTALHRLIEKNNINLHDIGRLEVGTETIIDKSKSVKTYLMTLFAEEGATDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRKAIVVAGDIAVYGKGPARPTGGAGAVAMLIGPNAPLVLDCGVRASYMTHAYDFYKPDLASEFPFVDGKLSIQCYLSALDNCYNLYCKKMRKIEPDFKGLLSLDGMLFHCPYSKLVQKSLARVCFNDFLNASPEQREEQFPGLSKFSSYKLEDTYFDRDVEKAFMTYSQTLFDEKTKPSLYIAKNVGNMYTPSLYGGLASYLISKSPEQLIGKKFALFSYGSGLASTMYSINICNDMSVGSKLAKLLSSLNDTVSLLNERQSVEPSKFSDIMDVRTKNYHTAPYQPSGSVDILFPGTYYLVNIDDLRRRFYERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWU5</accession>
    <name>A0A835GWU5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWU5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="30484" checksum="083179AE68D61B1F" modified="2021-09-29" version="1">MPYKWAAYLLFHMHFAQIFHTASICLTLSLAVWRYVAIKYSDKNHILCTERRCSTAILSSFILPPILCIPTYMVFDIHTAVVLEPSGPMILYHVDSDEEGQLYQINFWVHAVVIKLLPCCILTVISLWLIREVYSANQHQKKIRVYNKCPTNNKAVKRQYKADRRTNRTTKMLVAVLLLFLVTELPQGILGLLSGLLGRCFFKRCYDLFGELMDALALLNGAINFVLYCSMSRQFRMTFGQMMWRAHLHRWPPPTGSQSDGQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWI4</accession>
    <name>A0A835KWI4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pro-resilin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000765">
        <property type="protein sequence ID" value="KAF9405296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWI4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032582293" description="Pro-resilin-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23250" checksum="BCE9AC9744C0E759" modified="2021-09-29" version="1">MTLVKTIAITVCLVAFACAEPPPSNSYLPPPSSSRGAGYSQGPANQNFGPQIVAARNLDGAQGRAGHGVHAHSEHGGAAHARHGAEEPAGYPNSAARNALEELNSEPANYNFGYMVNDYQEGTDFGHHEERQDERAQGEYHVVLPDGRKQTVSYKADERGFKPQISYEESEDLGRSGGYDNNANNARSNQGNGYSNHGNHGNDHGYHGNGNSRANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXV0</accession>
    <name>A0A835KXV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein geranylgeranyltransferase type II</fullName>
            <ecNumber evidence="3">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rab geranyl-geranyltransferase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Rab geranylgeranyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000466">
        <property type="protein sequence ID" value="KAF9407476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9407476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="993" mass="112242" checksum="AB9DC6A5CD691C78" modified="2021-09-29" version="1" fragment="single">THLKKSAPRLNTCAKLKRINRHDDLFSIKKNLGIVFFLTFAANKAMIMRLLALRVCKELNQNSVHYDIVEITHSVTFNSYNKYRDELLEYLYGIIINIETSLTGILRKRIPRWPVVESLYSYNLCKKLPSFGPMYSVLMNNIKMTLNPKDVIISIDRPKILLLKKHIDYLAKYGTDQDDYEYNMTEYLRMSGIYWSLTAMELMGASDRMPKDDIINFISTCQNKETGGISACFPHDPHILYTLSAIQVLTMYNRLDAIDVEGVVKFVASLQQPDGSFYGDIWGEQDTRFSFCAVMCLSLLHRLDAINVDKAVEFVLSCMNFDGGFGSKPGSESHAGLIYCCVGTLSICKRLDALKVDALAWWLWVISSLKILNKMRWVDKERLEQFIMACQDPDTGGFSDRPGDITDPFHTLFGVAGLSLLGNSKIKPVNPVYCMPQETIDRLKLKPQIDVYTAYFQEINKEYDFIIVGSGTAGSVIAHRLATETNYTFIVIEAGTKSHALLEAPVLGPFFHGSLLDWQYQTVPQKHACYAMKNRKCKLAQGKILGGSSKLNNMIHVRGNLTHYQNWFHGKYTKEYIQKQFEFIENNVLYLNEVQYESELANTMLAAAKELGYAILDIDFKLGFRKNIVSQKYGKRWSTSDNLESKNVITNVLVEKIIFNGNTAHGVQVNSLGKKSTIYARKGVILSAGAINTPKILQLSGIGPENLLKSLGIPVIKNLPVGRNLQDHIGTGLDFVLFNKSVSISALDMINPFHVLEYFINGKGPWTTPGCEVIGFLSTKNQSEPDLQFMVLPVGLSSDRGSLLRNNVNIKDEIWDKYFSKSFDSYVGTILPLILHPKSRGYYTALLDPKYLSHKDDRDTLINGLKLVMKFANTEAIRNVGGYINQNHFPGCDNFKIFTDSYFDCYIKHLTLTSYHPVDASVLPTLPSGNINAAISMMASICFETIIKPDTNIPFCYKNDRINEFLFISFYKKLEGYPIHVVSDGILKVEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYH2</accession>
    <name>A0A835KYH2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000567">
        <property type="protein sequence ID" value="KAF9406642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="11480" checksum="45C359EC7FA82950" modified="2021-09-29" version="1">MDECGGHGQGHEEGESVACRLVHASYRPAAAPPRDVARTRFLLDNSLLFGLWRVLGNYTLPLPTSGAPLSSTPLSPLHCSVPNVTPPNRPLLPLLTMELDKDSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYI7</accession>
    <name>A0A835KYI7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HW555_011801</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BAW_Kor-Di-RS1</strain>
            <tissue evidence="23">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="EMBL" id="JACKWZ010000376">
        <property type="protein sequence ID" value="KAF9408559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYI7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000106">
        <property type="entry name" value="E1-E2 ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="88"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="682"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF9408559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="879" mass="96058" checksum="CF3D2537B9662D4B" modified="2021-09-29" version="1">MVKRDDGDVFLLLGTPSLRLGTPLYPESKLFSHLNVYFLLSTGSAVVSICMRQFDDAISITVAIMIVVTVAFVQEYRSEKSLEELNKLVPPSCNCLREGSLEHFLARNLVPGDIVHLNVGDRVPADLRLFDSTDLAIDESSFTGETEPAVKSVLPNKAAAGRVNKDNIAFMGTLVRCGNAKGIVVSTGERSEFGDIFRMMQAEEAPKTPLQKSMDTLGAQLSMYSFCIIGFIMVTGWLQGKALQEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNAIVKKLPTVETLGCVNVICSDKTGTLTKNEMTVTTISTSGGHIAEVTGTGYNACGDIQLRAYKGRDLDVARMAVNTMLEVGVLCNNATIRDDILYGQPTEGALLAVALKNGMRDVRDDYTRLHEIPFSSETKMMVVKCAPKFGDAKLKEEVFVKGAIEKILPLCTQYIDSSGNYAPMTKEKQNDFLGEAYNIARMGLRIIALCRGSRMESLSYTGVCGVCDPAREGVRDAVATLARAHVHVKMLTGDARPTALAVAQMVGLDVLHSQSLAGDQLDEMSDEELDRIIDNVSVFYRVTPKHKLAVVKSLQRVGNIVGMTGDGVNDGVALKRADIGIAMGRNGTDVCKEAADMILVDDDFGTIISAIEEGKCIFYNIRNFVRFQLSTSIAALSLIALATLMGIPNPLNAMQILWINIIMDGPPAQSLGVEPVDHSVLRGRPRDTSRRIISRALLLNVLLAAAIIIAGTLWVFNREMSDSRITPRDTTMTFTCFVLFDMFNALSCRSQTKSVFEVGLFSNKMFLVAVTRSVSWDRCSSSTSRPCRRFSKLKRSLDMVYLIFLVTLTSSVFIVSEIKKLIERSLKKRAAGKFTGKSRDAMDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZJ6</accession>
    <name>A0A835KZJ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000702">
        <property type="protein sequence ID" value="KAF9405658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZJ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="46516" checksum="856ED25A506FEF2C" modified="2021-09-29" version="1" fragment="single">DELQKKWKHLRDYYVKEKQDNTRSGSAAPKKRKNSYIELLRFLDVVKESRVSSGNISAPAGDNDQNENSCDEISTNTNTQPRNANAQETVTENFIPPQTEEVSGTSQMKKKPKMTAFQQSLITAMNKKQQSPKAAEEDADTKFLLSLLPQIKSLNERQNCEFRMEVMNLIYKLKYRNSFNMSHNQTYSYNHPGYSTYEQSPTTYSIPTGDMSPPVYQGYTTNSNSAISYSTIQSPESIETQRSIARQSTDERGADERDRRAPSAACSNSRAADVSVTVWCFIEHNVYSYARPTSATDVSDRGIWALKGQELEEMFGIPDGMISEDDLEESDSEQGTQEELVRVLTDSKELQDLHRQPHIRVLQLQDFRAPQDLHQYLHNIKVLQSHNYRVMQNQQHHHIRQIGLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0V8</accession>
    <name>A0A835L0V8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000431">
        <property type="protein sequence ID" value="KAF9407836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0V8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF35">
        <property type="entry name" value="FEZ FAMILY ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="345" mass="38491" checksum="629B715AD27C050A" modified="2021-09-29" version="1">MELVREESVTASEALRNGLCQSLWGASASRSEPRIASPPPPSHETPYPVREEIKFGINRLVSESTERTERTEDEEEEHHNETRPEGISPASRCGSPCWAPSPQSPRSVRSSSLELEVDSPPSSPRRPPDTSPPPKRSEAFSVSALLRPDAPRVQPQRPFLYPPLPFAEFLRDAGSLGLPGWGGYSNLYLHAVQAAGPELLRLRAAVLGAPGPLSRPLPLGDVYSCVKCEKMFSTPHGLEVHARRSHNGKRPFACELCSKTFGHEISLSQHRAVHSVEKVFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGKYQKIFYFSNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1S3</accession>
    <name>A0A835L1S3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000244">
        <property type="protein sequence ID" value="KAF9410832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1S3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="110"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="366"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="492" mass="55975" checksum="DB3148A31B5DFECC" modified="2021-09-29" version="1" fragment="single">MDPALAVELEALSRQKAMFEATERGDSVIQEFYKDKIVFLTGASGFLGKQLVEKLFRACNIGKIFVLLRPKKNMTIQERLEEMLQDPVFNLVKKKKPNFAENIVPVKGDVDIIFHVAATTRFDEALRVSTMINIRGTRESVLLGRDCRKLKSFVYVSTTYSTATEANVDKEVMERFYPCPLPPELMINMAENIDDDRMESIEANLIKGYPNTYTFTKSIAEEVVRSRAGDMPTCIIRPAVVISSYREPVPGWADASCAFGASGLILGPATGLIHAIYASNDVKFSLVPVDYVNNAILAAAWHTAKKETNDIQIYSVSSARNLFHWEPISSKIRDIGKVLPTPLAVWYTFIINTSNKPLFFLLTWLLHYIPGYILDAGCILLGKPTMFIKLYNRVNRSSLALSYFTSRTWVFNDNNSDKLFHSLSKSDRLIFNFDTTDINIPEFVTIWCVGLRKYLMKDGIKNTEYARKKQILLKYLHYFVSCVYFYALFKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1V9</accession>
    <name>A0A835L1V9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000157">
        <property type="protein sequence ID" value="KAF9413512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1V9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000001">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000040">
        <property type="entry name" value="Galactokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="108"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="295"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9413512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42233" checksum="6D7C449020B4154A" modified="2021-09-29" version="1">MSNEAIAKGEAVLLKQARDKFVATFGRQPTAAACAPGRVNLIGEHIDYCEGFVLPVALPFVTLIVGGLNGTGECRLVSVLGTGEEVSTSFQAPTPSSPLKPGPPAWANYVKGVVANFPGGVGGFDAVIVSDVPMGAGLSSSAAIEVATFTLLEGLTGRSVGLVEKAKLCQKAEHEFPGMPCGIMDQYIVTMGKKDHALLIDCRSLESQQIPMQLDDLVVLVTNSNVKHQLTGSEYPTRRAQCQEAADRLKLPSLRGAKIEDIEKLKQQNCDEEVLKRAKHVIEEISRTEEVARVMKNKDFKRVGELFYQSHDSLSKLMEVSCPELDQIVDIIRGAPGVYGARMTGGGFGGCVVTLVKKSEVENLKKKILSEYKGTPTFFLSQPSDGVRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2G9</accession>
    <name>A0A835L2G9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2G9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9412880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="536" mass="57843" checksum="C212A0C841255AEA" modified="2021-09-29" version="1">MVSLNPIRILKNEAEEEKAEVARMSSFIGAIAIGDLVKSTLGPKGMDKILVSSGRNAGQVEVTNDGATILKSIGVDNPAAKILVDMSKVQDDEVGDGTTSVTVLAAELLREAEKLIEQKLHPQTVIAGWRIAVDAAKQALADSSFDHEKNFNEAALRADLENIARTTLSSKILSNHKEHFTKLAVDAVLRLKGSGNLKAIQIIKISGGLLEESFLDEGFLLNKKVGVHQPKRIENANILIANTPMDTDKIKVFGSTIKVDSMAKIAELEVAEKEKMKDKVNKILAHKCNVFINRQLIYNYPEQLFADAGVMAIEHADFDGIERLALVTGGEIVSTFDSPDKVKLGHCKVIEQVLIGDECLIRFSGVELGSACTIVIRGATQQVIDEAERSLHDALCVLAATVKEPKVVYGGGASEMLMAEAVSRVAARTAGKESAAAEAFAVALRRLPSAVADNAGYDSADLISRLRAHHAQGETTMGLDMQNGRVGDMKKLGITESYVVKRQVLLSASEAAEMILRVDNILKAAPRRRGPDRRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2T8</accession>
    <name>A0A835L2T8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2T8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032732146" evidence="4">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="74" mass="8249" checksum="862EDF45FF58B1C3" modified="2021-09-29" version="1">MIKLFVFALLAGVLAIEEKPVAEIITESTIWETNSISVKGSYSYLTPEGEEYQITFTADDKGYKPTLRVVPAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3K6</accession>
    <name>A0A835L3K6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3K6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="15513" checksum="8F662DD95E7C4B74" modified="2021-09-29" version="1">MSIERRSCVNQAPHVTKRLLAIIVLLTGLLCMFGGYLLGRVARVEPRKNNEMLTHNLTILADSIYKKAKRIPPKLLHQNDPDKIQIRLFDIFNCTHLCGTLNKYNLAEFVRNSINFQVTKLMKSVNNASVYLDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3N8</accession>
    <name>A0A835L3N8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate kinase-associated protein mars</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3N8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="84381" checksum="7E7270657038A863" modified="2021-09-29" version="1">MEKSFDFGRLLKNHEKKHKSKPSQFGSVAGGVQKRLENNLKYRKSCRLTVFDNLRNLSKCESPAPVSNVQSKVEHRRQQLEKWKEEKEKKKKEAASQKKKPFVAGVPHAPLKFVPPPPPPKPMPSTSGRVTRSQSARNSVKAKENKELKSASQSFAPKNAAFKPPEIKTLTKLPKLFAPTSKKDKKHNITFDPVLPPNTQKESTKQTRSKTLKQTVEVKAVRKQAERATKGKWEYSPILMNKVTRKSLPAPSSPQVVTKPSRKSTPNITPNKPVPRSESSSEERLRSPKSLDSIQMTPEQIAEEAKNISPCVTMSRGKDNARKEMKKKLDEGLLDEDASHMESVDHFRRQLASEIKRMTEMCDTWDKISEQTVLPESIQEAVLSAVGQARLLMSQKLQQFASLVERCARPEPGTALITPADLHGFWDMVFMQVENVDMRFKKLEELRRCSWVEDQPVEVKKKVVRPNAVVKKAVKPTGGPSRLREMIAAARKAKKEQEEVVPCTLQPPAEDSKTFEAGFFSVRSPVRSPARSSHSPAPRTPASKNSLLKAVLSSEAKKASASKNSASFAMLRASVFGKNVECEGIALLPQTPTPLTPINLYATPGRSILKGANTNTNNKSTRKSIKMVLFNRSDTDIQDVSYRTAGSETHEEKSDEIQKDRDISSIDFEKIENKENSRRKSKLVRQDAEDRSPVVTRSRRKSMNTTVDENVLTPRRSSRKKVLHESEDNMVEEKPKRSARRRKSGVQVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L713</accession>
    <name>A0A835L713_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_002553</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GMP + ATP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L713"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000879">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9421620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="225" mass="25699" checksum="9DEBBC3468077431" modified="2021-09-29" version="1">MVQKGPRPLVLCGPSGSGKSTLLKRLLKEFPDKFGFSVSHTTRNPRPGEINGVHYHFTTKEEMIAAIARGEFIENATFSGNMYGTSKQAVNDVQCSGRICVLDIEIEGVKQVKKTDLNPLLVFVMPPSIEELERRLRARNTEEEEALKKRLDTARKEIIFGQEPGNFHIIILNDNLDKAYSELRDFISQNMEEKERALVETVIIFFSMVKLSEKLFFEDSDEMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Q4</accession>
    <name>A0A835L7Q4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Q4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="337" mass="37625" checksum="AE2CF22E951215D0" modified="2021-09-29" version="1">MNHETISEITAMSKLNPCCLSKIKNVAMKKLAHTQLVLTVNNKNVNNNTSCSGLCNKEILTIPVSIPNTPVLAPAFHNDELKSLAKNQPYISNSLNIPAFANALPAIVPNPVTLYGQPIYPLAGPVIQPLVTPIIPQVAIQQNVSNISDVSSDYYVSEQQVADAMDIYNDETFMQDKLYEELEPTNAGHQMDTSCKEGVGDPLEVYLSLPKTIFPSANMLAIDPNPIIDEFCKMPNMQRHAPWLLDLEFGIPKTVVTRPLPVYNVKLNSINCKNTPDAIHPGFESCYPDFKRVILFYYDCVVSAWYRGYMTITSDRSVENFQSWLLLPMQVLGMCWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7U1</accession>
    <name>A0A835L7U1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7U1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="38556" checksum="DD59B3B126283166" modified="2021-09-29" version="1">METNNGISGIGHNGTEIRREPVYGNTDFVDTWFLMGSPIPVAIILASYLIFVLKIGPAFMMKRAPYQLSNVLLLYNAVQVAVSCFLFQKCFSMLVENGVVPKTCLMETDYSRRSITTAMYFYLLAKVSELLDTIFFILRKKNNQVTFLHVYHHAVMVFVTWTALKYEPTFALVFMGMLNSFIHIIMYTYYGLSAYPNLVKYLWWKKYITRLQLLQFVLVLLQFGTSFATSSCPPSKIMFASMTFNVFLFIYLFGSFYINTYSKRNKKIEIAKESTGSNGIKVNELQKEDGEKGMRVCKDDKDYNRHLDNYTSTAIKLNDKYCFTFNLRTKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8J0</accession>
    <name>A0A835L8J0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="212" mass="24484" checksum="AFA55B799E1B8C21" modified="2021-09-29" version="1">MELPAETQQRRTFYSSKYKMAPVLSKNQKIGLAVLSNMNIMSVLEPADFRNYLRMDSRSFDILLNLVTPYIQKQNTVLRDSISAKQRLVVTLRFLATGNSYQDLKYSSLISQPMLSIIIPETCSAIYTCLEHYIKEPDYITRKWIDHENTSQGSIRHGDWRKHTDGLTSLKNTSKSQRNEEGNQVRNTFMNYFNSVGRVAFQDKMINAVPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8T1</accession>
    <name>A0A835L8T1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8T1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="873" mass="100580" checksum="3C47D4F631054CF5" modified="2021-09-29" version="1">MQKEKLIEEVRKYPLLYDLRDPKYSDVHKKEKAWNEIAIVLSQPASECKKIWQNLREYHRRAIKKKATKSGQSANTNKKWQYETEMSFLLPHYKERSTVTSVDNTDDGDDENSLSAAEILANVTNNEESQDSSIISERPESSNLKLTRSHKILALVPEKNACSEGSSSSDEETNVYIPPSPDTSDPPSLASSLEGLNLLDSSTESNKEQIDISVDAPLTPIFNEVFPSPTTSNYNILPTLNSIQSLPTPTVEQSSPQPGTSRQQLPLTRSKRKKTTRNAVTKKVAVKKFVLDYHWSKSVFRHSACLEENLYDLHQTDIDTALDYFYYFFSPDIITDIVHNTNLYSVQQLGRSIQLTEDEIKNFLAIQMLMGIVHMPAYTDYWGKRTRYPLIADLMPLKRYQQIRRYLHFANNTLEDSDRYFKIRPVMERIRQNFLKVEEEGKYSIDEMMIPYKGRKAGKRKQYVKMKPKKWGFKNFVRAGVSGIIYDFLLYGGDDTFRGLTFRDKEASIGLGGKVVIALCQTIRQKPAIIYADNFFMSLELTHILREEYGILSLGTIRTNRLRGCQELLPTDQQMKKKKRGSSAQVVCNKNKLAVVKWNDNKVVTLISSYIDSHPIETIKRYDKDEKKKVHVECPQIVKHYNKHMGGVDLADMLISLYRTPFKSHRWYLGIFSQLIDMCINNAWLLHKRDGKNIMLKDFRFQLFEGLTKSNKIVKGINATEDIGEDLKIHKPVSVRPTDSVRFDDKGHLPEAGDETMRCKYCKSEDWDIMEQVCKVLQQFEQITSSISGDKYLTGSMVIGITNCLKDFCEDFLNKEEYCASFNQAVIDVLRSLKYGIKDRFQGIEHSKSFGVCTLLDPRFKLVCFKMIMRSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAD2</accession>
    <name>A0A835LAD2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAD2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF134">
        <property type="entry name" value="AT07769P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032276972" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="289" mass="30340" checksum="DAF0A9B8D295DC81" modified="2021-09-29" version="1">MKIALVLVSVLVVVIGAENPLPNGVYDYHRRIGIPTAFKIKLQEREAAEKAQGRVVGGSSTTTLSVPYQAGLIIRINIISTSVCGGTLISDIRVLTAAHCYNDGNNIAQSFQVILGSNFLFSGGTRIDTNSIAIFPGYNPWIVANDIAVLRISRVSFSLQIQPINLPSGSELNSNFVGSTALASGYGITRDGDSVNLLQTISSVNLQVISNSVCGSSYGNIIQSHHLCTSGAGNVGICRGDTGGPLVTTVNNRRVLIGIGSFTANAGCQAGLPSGFSRVTSFVSWIHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAI4</accession>
    <name>A0A835LAI4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAI4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF159">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 74D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="672" mass="72722" checksum="28EEB0ED60398621" modified="2021-09-29" version="1">MTANVAVTVSSAGGEAGPPGPATEGTDMKGVEATPEEQERLATGNNNGSLDCKHTAAHPQPLRDRSVFASTRVFMLVFLSGWILQGMFLTYFVSVTTTVEKLFKVESKTTGTLLAATEIGQICTALFLTYLAGRGHRPRWIACMMIVLAFGVIGCIMPHLFYGTQLLEVHQEAHKVGAAPVCYSYQNSSDLCDDAHVKSSTTRSSITAVVIPWLFICLLVVGVGQTGIATLGIPYVDDNVGSKQSPLYMAITIGIRVIGPALGFLLGALCTRVYVDPFSTPDYDASDPRWVGAWWLGMVVVAAFIVLLSTLMFCFPRQIRYEPVPIPAKKIQEKHEPMFKDFLDTIKRQLTNDILMWRTASSVLHLMPISGVYSFLPKYLEKQFRLPTHDANLVSGLGGILVMGLGTITAGIVILKLVPTARQVAAWTATSAAIYSAGMILLMFVSCPEENYRMISEGGSIANSSVECSAGCYCADVAFNPVCGQLQMFFFHNVSLCFLRIERYNLYNSSEDILSRPLGFAVSGECGGPCSQIYVFVAIFAALMFVHASGEVGSVLLIIRCTDRQDKAMAMGVIQFAIGVFGNVPCPIVFGAAVDAACRARDAVCGMLGACVSYDNDSFRHFYLGLSSFLMFLACIMDMLVWSKAGRIDMNPADKPAPDASVALTNPSDTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAK4</accession>
    <name>A0A835LAK4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein smoothened</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HW555_005918</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BAW_Kor-Di-RS1</strain>
            <tissue evidence="23">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000068">
        <property type="entry name" value="Smoothened, frizzled class receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032443829" description="Protein smoothened" evidence="20">
        <location>
            <begin position="24"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="78"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="246"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF9416788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="761" mass="85882" checksum="376C3715031BD556" modified="2021-09-29" version="1" fragment="single">FLLFQMTPWRWLSGLLLILACRASQFDSGVDKNAITDMSDNATERLERINGTPNYRLIKPDKNTPWFPEPQIKLKSCVREARCETLNKTSCLGTKLPYDKTSVHLTFFENQYQIQTQLELYRELINVPNCWAVIQPLLCATFMPKCERILGRDMVFLPSYEMCKITMEPCSILYNTSYFPSFLKCNETLFPPNCENTMRELKFNTSGKCLPPLIHTDKPLHFYEGISGCGLPCRDPLYTEDEHQQIHRLVAWGAGICLALNLLTVATFLIDWRSANKYPALVIFYINVCFAVASMGWLIQFGVGSRDDIVCSKDGTRRQGEPSAEENLSCVVVFVLVYYFMMAACVWFVIFTYAWHMSFRALGKIQDRIDKKAAYFHLVAWSLPLILTIATMAFGEVDGSSVTGICFVGYENHPMRAALLLAPLSVVLALGGYFLLRGVFSLIAVRVSSKDVISPRAANKIRQTITRCSLTAALVAVFICVTFACHIYEFRNADLWKDSFKKNIICRLEALKATDKECSSGTRPSVSVLQLRLLCCFAAGALMASWTWTPAAAAGWRRYLARKCGCSVEAEVTRRARKHELIARAYRRRGEFAARGRLSISLGGSRQDPVGLCIDPTSPADYPDDAKHESGELSSSWAATLPRFVRRRDALVLPTHTHHSLSSTPDRRNSQDSQISISLRHVSVESRRNSLDSQLSVKIAEMKTKVGRRRPKHSKAKRKARAANTRKESTPSIESQISRYWLQAVAANNDPSREEVKFSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAL0</accession>
    <name>A0A835LAL0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAL0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="7">
        <location>
            <begin position="335"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9423296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="723" mass="82095" checksum="597CE8EAEE8F7B36" modified="2021-09-29" version="1">MGDNDDYYDGDGRMDSLGATPEVIYNWVDITSDFFKHIQDLQLGELLHDGHLFGLFEAMSAIEMMDPKMDAGMLCNRGNPKPLNFQQAVATGKLKIDDLEPPELIGIIDATMACIVSWLEGHSLAQTVFTNLYLHQPHSIVNKTLKAYCIAVYKLLDCIRDCINKAQVFEEEDFQPMGYGYRLGSNPQSGNTYDARLEVSEQKCVLMLREQEEDLNKKARSCDDEDNPWAALQARIRFTRMFFQALLMITKRDSQSGADCVALLNGCSEMMKVIIKTSGKGTQPVENSDSPNPMGFEPMINQRLLPPTFPRYTRIKPRAEALHYFDELVARLRHAWKITSCTNFHTALDFFMEFSRQRACILSRSALQLLYLSPSPANTASMAQSAMNGPVGQPRPQHPFVEILRESVKNFVNPPALTPKSPSVSTPQAREFVENFLARCVRPFAVLLQVCGHNRARQRDKLALLLDEFAALQEEAESVDAVVSGAAGTGPRACFGTWVLYHVLRVMIAYLLSGLELELYSVHEYHYIFWYLYEFLYGWLVSALGRAENLSGDSGRRDSRDSRRRKTKKRVRPYAREGLLCNVMQNLCGGYYKALVAFKLQGKIRQPQSEFDNEAVRYKHRFAPLSVLTPPQVHYHEFCEMTQPLQYENPVILYLGGCKHFQQARSLLETITTPDQEVQDLLKVAKTNFVVLKLLAGGHKRDSTVPPEFDFSVHRHFPIIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCF9</accession>
    <name>A0A835LCF9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032895390" evidence="1">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="34132" checksum="4AAF9C13E4A607FD" modified="2021-09-29" version="1">MTKFLEVIFLIVAVLWSESNGIPLFQGISFQRGFEINFKPLPRNPISFIKEKWSPFGVFGRKHVIQKRQVLDNLLVAGAQGPPIVPLSVEPVPRPAPVYERIEEPGLLQTPFLVTLPESTARPLIISSPLPPPASPVLTQGTPPRPVLISSPPSEQPNVVIIPSPPVLSSVPPPAGIQEVQIPPGRPIISDIPLLRPPAPTREGIPPISTNMVVPPGSGLFTDITRAVPVGGNVDSVQPSPGPPAVEENVGASIETNSIQPEPPRNRFTLNNSSLVRASRVALYFGSVFLQLMSQFMTNARATFDQMTNPPPVYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCI1</accession>
    <name>A0A835LCI1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosolic non-specific dipeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCI1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="6">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="692"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="108590" checksum="DAD3EF266D6789A3" modified="2021-09-29" version="1">MFVSVVPVFWNKIIIFTVARLQSTRFWGGVFSALLVDYRSQFRGWIPLRITPACAGFVLQYTRSTEKSVRIGMHQVLHGFPNPVVDREGFNTWLITVSDFVNKYHQTAFAANSEPTINIISQKPETPLTPPSTTSLQQLNLGHGPSPSSLTATMQEAALPSTSETNVHLNLGEKTTVKKAKSRVFLTNTEKYLQDKLVAASIKLSKMKNRFKKLSVNVKAAKQIASNPAAISYTFASSATKGPERAQQIKDVIRGLQESGFIVVATVCDQGPNNRQALKLLINENRGIYLRKGKNILPAECKDTADLLLFMDNIFDSVNGSRQKNRNAKPLLGPATPNSAHHQIWIEGVQIFKSMKFVSNGKKQSVPSITNWVWTLSRINKLQNEFNVSSVWLRHLNQDPLENFFGAMALLVVTQFDIEDWSLFPIVKMYSVMTSCLIRSVKCICNDIKFAAARASGPTKNFINRPVYRIYSVTPKQNPKMADRTLPQIFKYVDDNKESYKQLLKEAVAIPSVSCDIKYRKDCVRMVEWMQEKLKEVGATTELRDVGYQTIAGEQVKLPPVLVGVLGKDPKKNTICIYGHLDVQPALKSDGWDTEPFELVERDGKLFGRGSTDDKGPVLGWLHAINAYKGVGEELPVNLKFVFECMEESGSEGLDALLIEKLKPEGFFKDVDYVCISDNYWLGTTKPCITYGLRGISYYFLEIECAKMDLHSGVYGGTVHEAMTDLIYMMNQLVDKDGKIHIDGIYDSVAPLTENEKKLYTTIDFDTEAYRQSIGAHKLAHKGDKEQILMHRWRYPSLSLHGIEVLLVKIMCRIPTWSKNSNSRQSYWQVSIRIVPNQEPEEVEKLVFDYVNKKWAERGSPNKMTITAQSGRAWTENPDHPHYQAAARATRLIYMTEPDMSREGGSIPVTITLQEASGRNVLLLPMGAGDDMAHSQNEKINVRNYIEGIKLFAAYLHEVSKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCX6</accession>
    <name>A0A835LCX6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HW555_003785</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">BAW_Kor-Di-RS1</strain>
            <tissue evidence="28">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66020"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:16949"/>
            <dbReference type="Rhea" id="RHEA-COMP:16951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:166867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:66021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66024"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:16949"/>
            <dbReference type="Rhea" id="RHEA-COMP:16951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:166867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + bromide + H2O2 + H(+) = 3-bromo-L-tyrosyl-[protein] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:69360"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:17686"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:183512"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:69361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>bromide + H2O2 = hypobromite + H2O</text>
            <dbReference type="Rhea" id="RHEA:66016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hypobromite + L-tyrosyl-[protein] + H(+) = 3-bromo-L-tyrosyl-[protein] + H2O</text>
            <dbReference type="Rhea" id="RHEA:69356"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:17686"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29250"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:183512"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:69357"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the hemolin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the peroxidase family. XPO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCX6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09826">
        <property type="entry name" value="peroxidasin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000001">
        <property type="entry name" value="Peroxidasin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034824">
        <property type="entry name" value="Peroxidasin_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF58">
        <property type="entry name" value="PEROXIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 25" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 25" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="129"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="321"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="416"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="1236"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00061342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF9419786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1267" mass="143790" checksum="F540672AE916CB57" modified="2021-09-29" version="1">MKNNLKLLVNELRPLDRLLRNKSGRYLHINEIHQIDPQTFSNLPRLERLYLHNNHIKRIPAGSFSAMPKLRKLRLDSNALICDCSMLWLVKMMAQHNDMYIDATCYQPARVTGMPLSIMEERDFECKIPEIQKDPEDITVNFGEAAMFTCVVTGDPTPDIIWLRDSNEIPIDGTRYEVMENGTLMLHDITDVDTGYFECMAKNPVGEVHSKPAKMTVQHKRDSANLQKAAPVFTVRPQKQFAKLDQSINFDCAANGHPKPHVAWLFNGERILLNERISIRSNGSIFIDDIQESDAGLYTCLAENINGKVNASATLEVMVPPTFILEPHNKTVRLGDDVEFICTAKGVPKPLINWFRNTLVLPLTENIILSNENQNLTILSVTADDEGIYHCRAENAEGYVEGSAFLTVENYEIIRPRIVLKPEDTDAYRESSVQLPCEIESEPPATVEWRKDGSYLDDSRKHSITIIGSLILHNLTLRDTGRYECSVFNEYGRDTASAFLTVKDRVIPGDEYVNIALTEATRDVDLAIERTMDELFNNNNTSKTDISRLYRITSFPNAPAREVARAAEIYERTLDKVRDFIQSGHKVTSAEPFLYQNVLSNQHLEVIARLSGCVAHRDKNECSDMCYHSKYRSYDGSCNNFAHPTWGSSLSGFRRILFPIYENGFSQPVGWNKDIKYNGFSLPSARLVSTSIITTDDISEDQQLTHMVMQWGQWLDHDLDHALPSVSSQTWDGVDCKKTCAYAAPCFPIDVPPNDPRITNRRCIDFIRTSAVCGSGMTSVLFGTLQPREQINQLTSFIDASQVYGFEKSVAEDLRDLTNENGLLRVGVTFPGRKPLLPTVGINGMDCRRNLDESNRNCFVAGDIRANEQIGLAAMHTIWMREHNRIAIQLKVLNPFWDGDRVYHEARKIVGAQIQIITYEHWLPIILGAEGIKQLGQYKEYDPNLNPSVSNVFATAALRFGHSMINPLLHRYDENFEPIAEGHLLLRHAFFSPWRLVDEGGVDPLLRGMFTTPAKLKTPTQNLNSELTEKLFYSAHAVALDLAAINIQRSRDHGIPPYTKWRQFCNMSEVNDFDDLAGEITDETVRNKLKELYGSVHNIDVWVGGILENQVEGGKVGPLFRCLLVEQFQRLRDGDRFWYENPSVFKPDQLRQLKETSLARILCDNGDNIDTIGENVFLLPEVQDGLVSCEDLPSMDLRYWADCETCGENGGLERAKRRARRDTETDDDILIDEARINGLEDSQHEMENTIASLKKRIEYLEETCKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LD15</accession>
    <name>A0A835LD15_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_003652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LD15"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF253">
        <property type="entry name" value="PICKPOCKET 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9419940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="552" mass="62374" checksum="180205633AEBD81C" modified="2021-09-29" version="1">MAISPRAALVVTSSAGRLARAIDIYRYSAQHADRGPPAVGARPEQVGAREAGPAAPGAGAPPARQPAGRRRRLLAPLLRGVYQYRARPPLYVQKHSTSVTHTPFPAVAICSNKVISRAALRNLTRHLYTTSANQRYQYSEAEIEDNLVKMGALLTYAYTDVNFMFTKFMRESMPQFNITDIMYRFSANCSKILLRCSWRGKVRNCEHLFATRLTALGFCCVFNSRYQPADFGREPVVLDQTGKDFGLGAVLHEVQDDFAYIRRPAYGMEVLLFEGSEFPIVEGGDVRVYPLPINASVYFNIQALSQQPADEISSYSETRVRHSNSPAAPAGRHLVYVSCPQRGCRLGAAGMSQCLAECRRYTAEALCKCVPYTLQPQCAPRAAATCTLNELACLSKHREKFMYVYPGDEADVSLNQEQQDSMVCDCVVHCRRLQYRATVSYSFYRSKPHVFQNFLTKNMSLKSTTSLRLFYGVDRQQWYKVEVFSRLSDVCVKLSCQWMAITGITLVSCWELVYHATYRWLRHFARRRTAPSIPRRSTRGPPHATRRDYIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDZ3</accession>
    <name>A0A835LDZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="173"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="564" mass="61511" checksum="68E58A0E29665BAD" modified="2021-09-29" version="1">MQGMKVEAVGVQVGEVGEGVRKWRNRKGDREAMEALKAPIVICCGNKEDLKKTEDQLKNTDGLKFEPAASRDPRVVIRNVFSYNSEKDIVESLKVQNKRLWLDMDPSHFRVKEAYRKKARNPHQAHESTGLPSGAVLGSPLSRSLTSARRGGEPDVDYRCLEDMLPETVARLQLPAHLIYTDGSKSVDGVGAAYSYWRDGTEIRTKRMRLESMCTVFQAELLAIARATDLVVRGGFGCAAVLSDSRSSLDLIRNSETHHPLATHIRKNIRELEGRGKILQFFWVKAHVGIPGNERADELARLAAAQSRVAPAYDRCPVSYVKRRIREGAVHRWNERYTGGATAEATLGEDRLGTRDGALQPHRPSPALSGAALDRFDGAAPAAATAAPPLHGTVSSRTRSAPVKTTHFTGLHLGRVCDSLPEPPQRLAPCPGELKMAPAGCGGLGATFFFPFRFLGHHLWVGPLMGCGVGPLGSCRLGSRGGRGSPLDPLRLCALSLITPGAAREAGPEDHLRHAFRRRWCAAPHAVFSSACLEALRRAIGASAALPERIFFPHALRRLPFSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFJ9</accession>
    <name>A0A835LFJ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFJ9"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="139" mass="14892" checksum="1CAFCC9C249FF0B0" modified="2021-09-29" version="1">MADVEVEVPANPVLSGGAMDVNTALQEVLKTALIHGGLVHGLHEAAKALDKRQAVLCVLAENCDEAAYKKLVQALCNEHQIPLVKVDNNKKLGEWAGLCKIDKDGKARKIVGCSCVVIKDFGEETPALDVLKDYLKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGD6</accession>
    <name>A0A835LGD6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HW555_000328</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">BAW_Kor-Di-RS1</strain>
            <tissue evidence="26">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGD6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF9424517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="743" mass="84739" checksum="80B5FB21B3335029" modified="2021-09-29" version="1">MKLTVDGLLVYFPYDYIYPEQYAYMLELKRALDAKGHGLLEMPSGTGKTISLLSLIVAYMIQNPHHVRKLIYCSRTVPEIEKVLEELKNLIKYYEKSQGEKPSLTGVVLSSRKNLCIHPDVSREREGKLVDGKCHSLTASYIRDRHESDSSIPICQFYEGFNREGKESMLPYGVYTIDDLKQYGADRNWCPYFLSRFAIIHAEIVVYSYHYLLDPKIAEVVSKEMNREAVVVFDEAHNIDNVCIDSLSVKVTRRTIDRSTMALQQLEKTVAQIREADAARLTVEYEQMVEGLRHAAMQRETDAVLGNPILPDDVLNEVVPGNIRNAEHFLSFLKRFIEYLKTRLRIQHVVQESPAGFLKDVQARVCIERKPLRFCATRLSSLMKTLEIPDPSNFASLTLITHLATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCMDSSIAMRPVFARFQSVIITSGTLSPLDMYPKILDFNPVIMSSFTMTLARPCILPMIVSKGSDQVAISSKYETREDVAVIRNYGQLLVEISASVPDGVVCFFTSYLYLESVVGAWYDQDSAETSFALINYIKACESGRGAVLLSVARGKVSEGVDFDHHLGRAVLMFGIPYVFTQSRILKARLDYLRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRADKRTKLPRWIQEHLKDSLCNLSTEEAVQICKRWLRQMAQPFTREDQLGVSLLTLQQLQSEEQQEKIEKQVIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G309</accession>
    <name>A0A835G309_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000639">
        <property type="protein sequence ID" value="KAF9406108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G309"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="824" mass="95216" checksum="4C594E30A0E8055A" modified="2021-09-29" version="1">MVVKGGSTTNLKKHLMKKHRSTYETIIPCSVSDAAVENNLEAPSTSNKALPSTSTKVQKKLRDELETAKYVSITTDGWTSRATTSYNHRHGSLALSFTCAKVNYWVLLVLNLIWNNVSRSPVNNVGYQLATMFAGCAGRQRVRLCQYGPCCAGVRTLHDFVAKEIYLSSARLVKLATKESEEHVMDKNKSIDLNISTSTDIYEEADKRESPLPSGFENQLIKLNELLGDVFNEDDASTKENIEPTAPSSEKIQSTSSTTKNIEPTVSSAENIEPIASTSTHFEIIVDHEITPMPSPSSNEICDDTFCVGYAESENPPILTNDDLYGNLPTPSVTSFSSVYTPTAQSKQTRQPTFKRDKGKKRLIHKENWVGKHIQEKQLKEPCNEKCRLKCSTKFSEKQREIIFKKFWNLGDRQKQWHFVIMYTQKIPKRRQTTEVTKHDRRNTFYYFLPNEDKQKTKVCKTMFLNTISAGERIVTTSWKKYDGEMTVSDDKRGKYIHKANVMDEEMIRSVCDHVKSFSLVESHYIRKDSKKLYLEDVKSASRMFNLYSEWFDSDKYRNKASTKRQYRDILNANFNIGFHKPKKDLCDVCHVYCNKEIPTEEEKSAFLKHQSAKKAARVLKQQDKNEAISNEEIVAATFDFEKVLVTPHGDVSVFYYKRKLSTLNFTLYELATKEATCFMWHEAIAKRGANEVSSCLYQFIKQKVIQNKWTRLREVTVHALHYDRIEYKYNFEDEPKTIKILRSGNRNTERLSREFEIKQAYDGDLPISRNKYKDLINLCQTNIIPEKYHNFYQKLKFDQNVQEPLEDIDEDSLIMTDMILFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3A6</accession>
    <name>A0A835G3A6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000660">
        <property type="protein sequence ID" value="KAF9405938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3A6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="166" mass="18376" checksum="D78F14566BF5611F" modified="2021-09-29" version="1" fragment="single">GVEANEPEAKRFRATERFTGRCNFCGISGHRFAECRKRRDALGSYFRPLERKNDVTCYTCGQIGHVTTNCPDKRNGGKAAAKEVHQCEHRPSRGNLTTSSASEDEENITNSNHDNDNSDTLTVCSNTVSADSRTLTAGSDTLSTYSDPETWEVSHEAEIHTEQDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3Q1</accession>
    <name>A0A835G3Q1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Achaete scute target 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000568">
        <property type="protein sequence ID" value="KAF9406635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3Q1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="52"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="421"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="58427" checksum="F758C2552F3CF666" modified="2021-09-29" version="1">MFSWLKKEGEKSESIENVVEGLKRIYKTKLLPLELHYQFHDFHSPQLEEPDFDAKPMILLVGQYSTGKTTFIKYLLERDFPGIRIGPEPTTDRFIAVMYDEKEGVIPGNALVVDPKKQFRPLSKFGNAFLNRFQCSTVSSPVLKGISIVDTPGILSGEKQRVDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFRRSIEALRGHDDKIRIVLNKADMIDHQQLMRVYGALMWSLGKVLQTPEVARVYIGSFWDQPLRYDVNRRLFEDEEQDLFRDMQSLPRNAALRKLNDLIKRARLAKVHAYIVSELRKEMPSVFGKDGKKKELIKNLGQVYDRIQREQQISPGDFPDIKKMQETLANHDFTKFHPLKPKLLEVVDHMLATDIARLMDMIPQEDVNIVSEPLIKGGAFEGVEDQVKEKPRYDQIFQALNPIDGKVTGAAAKTEMVKSKLPNSVLGKIWKLSDIDKDGFLDEDEFALAMHLIHVKIDGHDLPAELPAHLVPPSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4E0</accession>
    <name>A0A835G4E0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4E0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="586" mass="67865" checksum="09E682A8DB8C1D16" modified="2021-09-29" version="1">MAHPKMEDDIDIEEHDVLDNPRIKSIFPDLSRVKIEIPDEDDALVEDQYEVPIENQEALYQYEYSFGNNEENEEPLHYEDEEVEDEGQSYFFNNQIILGSKPPVDWDALKMEALTSNTVVDLENWGPTLEASPCYCNSCSILFPTVNALDAHKMISHSYLVAMDLSPKNTARKSTVPSKYCNHCSKTFPDDTSLIKHLYELLPLNFPVKEEPEDTETVKPKKIAAQLPKKLKSSTPVPKKIKVEPKEEVEPTLEVPKRKICFKLPRDGKFFASSSLVPRGTLFQCNICQIGFISCFAALQHSKYCEKALAFDKCGVCKRKIRKKDSAIHSLQHQTNDKLKIYTVNKNMYDKVLCKCPKCLSCFDELGFWAHYGKCKKSERKSTRCPDCDLHIASTRYQLHRIKHASKKLSKKELIVIEFFDHSAKGTVDMRKTAKEFKKKFREKIKRTRQGADVVIYPHDIPLYYCDVCGCCQYKLSYKGHVNGMCRTYKSKKYCEKCGLCFSAKGITSHRRLHANRSFQLKDIKIFNLSSGQVMEPPLPEMYRCEKCEKHFLYYRNVRFHKCKQEKFVTCKVCSKKFNIQAYKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G529</accession>
    <name>A0A835G529_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000352">
        <property type="protein sequence ID" value="KAF9408928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G529"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="334" mass="38022" checksum="676A6E48679FD3F4" modified="2021-09-29" version="1" fragment="single">MSRAVRELGLKSWYYLSKHTHNDENNQYGIGSRESPGLHHNAVIEAEAFREELLCQVKKTLKDIADGNITKSIMELMIDKNTGRMLKTEDIIRRIVSSRSQAIASKICVQPCQPVKDVVKPTQKKTSRARKNVGSLKRISTKSKCTITPSPNNYSRSSGLIYKIRKAFLTQSRPPKQQKKKINIPTKLPPPKSTGALGKSLIKIHKAMKQSEIAPSYLKMLKSLDKNNGKYDKLPWNKYDIMAKLRTEEGHAEILREICKAIKTGRVSPSLIELAISKKLERDSVQHKQEPFRTTQSKKLESKRFYKKPMNDKGIIIRFDTNVGQNKISRKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G545</accession>
    <name>A0A835G545_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000599">
        <property type="protein sequence ID" value="KAF9406386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G545"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="894" mass="101583" checksum="ADCAB745A41B7CC7" modified="2021-09-29" version="1">MSSRQFRKVNGQANLPPPPDDSDEDYQPLYARRPANSQYAGLALSSHSESDRSSRSEEELQDRAEALPVQKKNTKKKGGGGKGRGRRTSNDVDDVDRSIQEVNAMLGSPSSLLPSAAGTSESPKVNEALQVLTVDARHLNVTNEVRRLFGPDENELNKRGRMHSSRAFMLRRVLVHPNKDTLIYEFNNVGLSMSKYKEVNKRMYFVFNHNESYQKMHRAFLAKYSRAQSTELLMGLEEARRNMHVEALLEISDRLFRMEENGVANEIVENVVLFLQYVAHPLFILSQNNVRLDYKYMENRPFHVAMLKYVYLLSNKACHRTALEIAKMLLLLDPNDPLALLALIDILALRAREHEWLIDAIRYFDRQREAKLLFNIKYSNALAHFHVAIKNRGDFNESDQLIKEAILAHPQVFVHIMACCGVSNPAILNHAIFKRDLQNPWTPGVEELFLIYAKMTAPRWNEPPVMGWITKNAGELCKSYDEDATVRETANDWAVSRHGLFQVWPPEYLRHISVLSCMSKLILDMPVNSFFRPTCGWDPVFDKSVNRYGYSYKTDPPRNLGVGGSPVYRYAAPDYAFVPHHEFVNPAFMQDFGPEFAPEFGPEYMPNGAYPESDNENDREAHRPQEQVQQAVAPEQMQQPVPYVGYELPYFEIPGPLLEAPLLAGPQFWLPIEAHDVPFDMPRNIPPEHLANETIFDAETGYINYDYDDDEGNFATYEKDMAAALAAVSLDDNIGIGNILFIVKNLIMVHNQPTSIFCIIATEFCERFSFCGLRTILSLYLRNVLCLHENAATVVYHIFIMMCYTMPLMGAILADNFIGRYRVILYFSIVYLIGTVLTCCSAIPPLMLPPTAKFDGTISAVCSDSAFGRALHRGATDLHPTQIFVQFTGWTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5L2</accession>
    <name>A0A835G5L2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Attacin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_011332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the attacin/sarcotoxin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000327">
        <property type="protein sequence ID" value="KAF9409245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5L2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005521">
        <property type="entry name" value="Attacin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005520">
        <property type="entry name" value="Attacin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03769">
        <property type="entry name" value="Attacin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03768">
        <property type="entry name" value="Attacin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032452203" description="Attacin" evidence="10">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin N-terminal" evidence="11">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin C-terminal" evidence="12">
        <location>
            <begin position="135"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9409245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27474" checksum="623F77B40F61D4E6" modified="2021-09-29" version="1">MFALKLILAAVLVAASARHVPQDHLAYEQVHLLGFDEDERPVFEHEDLLPELEESCQPQHLTRARRQAQGSVTLNSDGGMGLGAKIPLAHNDRNVLSAIGSVDLNNNMHPTSKGFGLALDNVNGHGLTVMKESVPGFGDRLSGAGKLNVFHNDNHNVAVTGSLTRNMPSIPNVPNFNTIGGGVDYMYKNKVGASLGMASTPFLDRKDYSAMGNLNLFRSPTTSVDFSGGFKKFESPFMSSGWKPNFGLTFGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G697</accession>
    <name>A0A835G697_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000425">
        <property type="protein sequence ID" value="KAF9407893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G697"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="212" mass="24499" checksum="566A9668AE9B98B7" modified="2021-09-29" version="1">MKKKRRRIQNHRRPIHRRHWVHPILTSRNKNGQHKLLFEELKCYPDKFFKYFRMSVNSFNELLSVLHDDLKHQDTRMRKSISPTERLAITLRYLATGCSFGDFELVYRCGASTARLIESDPWTSCTCIQYAAYNKTRPGRRDWGAARRGGKKPATVAVYAHESNDKTQPQVASALDSRSLWLGRGHSSAQCAPILYKMYEETRPQVVAATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6A7</accession>
    <name>A0A835G6A7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_010880</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000291">
        <property type="protein sequence ID" value="KAF9409882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6A7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="268"/>
            <end position="413"/>
        </location>
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        <location>
            <begin position="416"/>
            <end position="481"/>
        </location>
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        <location>
            <begin position="548"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="583"/>
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        </location>
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        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="164"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
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        </ligand>
    </feature>
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        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        </ligand>
    </feature>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        </ligand>
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        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <end position="297"/>
        </location>
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        <location>
            <position position="601"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
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            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF9409882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="601" mass="68114" checksum="99810B7590DCBCA0" modified="2021-09-29" version="1" fragment="single">LKGKQAVVGVSVPRSVVVCGCVISLELTRCVRIMSKMWSNSKYSLRNNSKPYNLEKINKRQTQQRSRTYGLTSAISHDGPKLADVDKNERLREYLASYGVFESEQETQHRCEVLGTLHQLVRQWVREESLSQNMPAEVASSVGGKVFTFGSYRLGVHNRGADIDALCVAPRHIERRSFFSTFYSLLKAQKQVKDLIAVKNAYVPVIKLNFDGIDIDLLFARLPLSKIPNSFDLDDDMLLKNLDQKCVRSLNGCRVTDEILRLVPNVENFRLTLRAIKLWAKRKTRNLSNALGYLGGVSWAMLVARTCQLYPNALPATLVNKFFLIFCQWRWPLPVLLKRVDPDRLGFPVWDPRVNLADRYHLMPVITPAYPQQNSTFNVSASTRSVMVEELKIGLAASEEIMKGNCGWECLFDTPNFFSKYKYFIVLLASSFSPDDQLQWSGLVESRIRHLIATLEQNTSIALAHVNPECFNTAPLSATTGQHTSNCCSMWFIGLRFEKSTLNLDLTYDIQTFVENVNSQARKTNMLKEGMIIQARYVRRKQLNQYLPASQLRRERTSPGTNSSSESTPSPRPLLSPPLVHSMQPSDSLGGNKLDFQNTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6D3</accession>
    <name>A0A835G6D3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000402">
        <property type="protein sequence ID" value="KAF9408167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6D3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF134">
        <property type="entry name" value="AT07769P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032269155" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="279" mass="29799" checksum="1D989F3FEC537D56" modified="2021-09-29" version="1">MKVVLACVCVLGLVWQGYAAQYHERVGIPMARQIGLQESMRITGGLASYNGEHPFFAGLIITLKTGITSICGGTLLSHYHVVTIGQCWYDGENEGREIQVVLGTVTLFSGGTRKTAETVTLHPEFNPFTLANDIAMIVIPYVSFSTYIAPIVLPVAYFSSLAGYTAEIIGYGRTSPDAPLGGNSSLNDVYVKVMNNTDCNRIYGDVVTSDMMCTSGAGGKGACAGDYGGPLVLRRYIGASGQDMLVGLVSFTAAAGCNAGYPTGYTRITSHLRWIKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7W6</accession>
    <name>A0A835G7W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">mRNA export factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_017439</name>
        <name evidence="14" type="ORF">HW555_012021</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000398">
        <property type="protein sequence ID" value="KAF9408211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000846">
        <property type="protein sequence ID" value="KAH9629924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7W6"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000084">
        <property type="entry name" value="mRNA export factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9408211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9629924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38987" checksum="6AD87275C211EF7C" modified="2021-09-29" version="1">MFNQPSNPNKDLEVTSPPDDTVSALEFSPPSLQQTFLVSGSWDCRVRCWEVETTGKTIPKAVQSMDGPVLDVAWHDDGSKIFMASTDKSVKCWDLASNQCMQVAAHEAPVKTCHWIKAPNYTCLMTASWDKTLKFWDTRSPVPIMNMNLSERCYCADVDYPMAVVGTADRGICLYTLEGKPAEFKRVESPLKYQHRCIAIFRDKKTKQPTGFALGSVEGRVAIQYVNPTMPKDNFTFKCHRPPANTSGYQDIYAVNDIAFHPAHGTLATVGSDGSFSFWDKDARTRLKSSEMLDQPLTKCAFNHNGQIFAYAVGYDWSKGHEHFNPAKKNYIYLRACYEDLKPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8N3</accession>
    <name>A0A835G8N3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Motile sperm domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000273">
        <property type="protein sequence ID" value="KAF9410208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8N3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="73"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="260"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="52210" checksum="BBA6348717868E2F" modified="2021-09-29" version="1">MATPADVRAIFEARLKETSPPPDFHPLDLERAKDEKYLKRVLQHMDKDAKEAANMLWDICVWRKSVGANDINESNIRLDYVKEGVFFTHGRDIDGSLLLIFKAKMHVKGQKDYEEIKKILIYWFDRVEREEGGKRITLFLDMEGSGLGNMDMELVKYLITLFKLYYPYFLNYIVIYQMPWVLSAAFKVVKTLLPAKAVERMKFVTKDTLKDVVAPEQALVSWGGKDNYVFEFIPENRSEHTPKKVTFAEQGDSQHSPGEMLRLVPNDTIVFKTEGDEISGQFTITNMDDSAVSFKIRTTAPEKFRVRPSSGTLASGASQTVLIVVQPGIHLRTVTKDRFLVMSIQIPKTDVTPKELTEIWQSSTGSKTDEYRLKCQFPEKDIPKNGNIVEGKSLDKSDSATSALSNLEKNYAKLHRDLKQLKLLQFVTLTMTVLVAVLGYLLYENMVEENRYCERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8R4</accession>
    <name>A0A835G8R4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_010615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8R4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF388">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="369" mass="41435" checksum="5E559DCCCAA6CBF0" modified="2021-09-29" version="1">MHALFGEQSPYAYRGGAAGGYSAGVTPYAYEQYRYGYGAPYLHPHQQHVGAPKDMVKPPYSYIALIAMAIQNAPERRITLNGIYQFIMERFPYYRENKQGWQNSIRHNLSLNECFVKVARDDKKPGKGSYWTLDPDSYNMFDNGSYLRRRRRFKKKDALREKEEALKRQQQLQQAQEALTAQEALTASDTLGQQRDVKPDVKPRIFECRPKREPGADCARYDKPVDSLDDFSEPRLPASAVYCSPQPYSLVAEEFRAATSGWYAAPEPPAEQLPPAFRDLFEPPSCQLAGFRSGSPVPDAYLYACALRCFFSSSVASANSAVRVGQPLRRTIGGAPVCTETLRDVVVVAGGRHRSAPNGFSRTRQFQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8T1</accession>
    <name>A0A835G8T1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_011588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000356">
        <property type="protein sequence ID" value="KAF9408873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8T1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="266"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9408873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="501" mass="55778" checksum="29EBEA0A150B374F" modified="2021-09-29" version="1" fragment="single">VLIAATVCTKSGKALVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASNILEDLETLRLFSRVVPEYCTQLTEAEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVEMDSHEEKIYQAVRQTQEREAANRMRERAKELQRERLEAAKRGVPTRSQMSFGSSFGSSNMSSSASTEPIAEKIPTTPARETARPAGRSAMKLGARGTDTESFVSRLRSEGDAVSAVAAPAKPDAAKPPPPDHKDVHLRFEERLTLVAGRDGDVQNFELSGLLTLRISNEQYSRIHVHVDNQDPRPLQLQTHPNVDKEAFRANGVIGLKQSQRAFPLHSDVGVLKWRLNSNDDKLAPLSVNCWPSEGAGGGCDVNIEYELEHDHLTLSDVHIHIPLPSGNTSVIVHQWEGSYTQKGRTLIWSIPIINKHQKSGSLEFTVTPAVPNDFFPLTVTWTSDTSLALLKATKVTYAEDNTPVDYSQEISFHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8W6</accession>
    <name>A0A835G8W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000367">
        <property type="protein sequence ID" value="KAF9408699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8W6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="385" mass="41576" checksum="E0AF81721BF85EC1" modified="2021-09-29" version="1">MTLNLPEDEGEGLGFRLTRTLWDPYPWVREVTPNGRADEAGLKPGDCLLQADGKDLLGLPVSQVAGLIRGDGEGGGVSLLVWNCGVDPKDDPELLWSCGGGARGERSRRALAGAVRALACCVCASTATTPLSCARSHLYCEPCWVRLERCALCREALPSKNSPYARNLVAEQVLEAIAAEYELKNTKIKPRPTQTTSAYTSPNRSRNTSPRRGQYQHSMMNKYKKNVHFPEKFGQTYASDPNIHRSVNRVTVNNITNPTNSAEAGNSGCKCQCQSDSCVPKINVGSAEGSKCAGSDCSSSSQSLSIPHKLVARLRQACSLADLNNVVGQCSMSQSLNNLGDKCKNCHHGSLDNLKNHCSNICDAPVLLLPAPPIYVFACEHSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G930</accession>
    <name>A0A835G930_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000328">
        <property type="protein sequence ID" value="KAF9409235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G930"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21283" checksum="D7F2F8FFED0BEBA5" modified="2021-09-29" version="1">MMFFHAIRNGQRCIFSELRRDRTSLFRMTPGLLNFNCTRYKGHEIKYKPYVPPPVMDHDHKNMALKRPMSPHLTVYAPTVPSMTSVTQRATGAILTFYAFSLAFGALFLSNGVETYVSMIQSLNLGRLTTFLVKIILGLPFAYHYFNAMRYIIWNTARMLDIKKVYETARQAAIAAVVLAVLFAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAF5</accession>
    <name>A0A835GAF5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000229">
        <property type="protein sequence ID" value="KAF9411302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAF5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039210">
        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="5">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="265" mass="30301" checksum="BA9EB3A7913E1A51" modified="2021-09-29" version="1">MQDVRKRAKSNDKNVSERNIPKNNESNDYTEKYLLCFQSKNDKVKTFAKQSELLPGKGLVVDCSPSYKEEVEKYEGCVPKECKRSLIKEAEELLAIAKKGLKLGGSSGGASILDLHSGALSMGQHFVVKEKIKYAVAHHFGVKPNKIYLTHPTFFSEITSKKAVTMHDEYWHPHVDKETYKSFHYTTLLYLGDYNIDFKGGRFVFVDEKFNRTVEPRKARLSMFTSGRENLHYVEKVTSGNRYAMTISFTCDQQYAIQDPSINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBS5</accession>
    <name>A0A835GBS5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBS5"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000899">
        <property type="entry name" value="RNA-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="19943" checksum="F997F686F505560B" modified="2021-09-29" version="1">MSRYGDCKVYVGDLGNNASKPELEDAFSYYGPLRNVWVARNPPGFAFVEFEDPRDAEDAIRGLDGRTICGRRARVEMSNGGRGYGGRGPPPRSRLPPRPYDDRCYDCGDRGHYARDCTRRRRRSRSRSRRRTRSRSPRSGSRSRSRSRSRSRSKARSMSRSRSRSPSKDSKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD22</accession>
    <name>A0A835GD22_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD22"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="379" mass="43712" checksum="668F4E25BFDB9D99" modified="2021-09-29" version="1">MAARLITDDGIVRALDDEDYVNTNDVSSDSENEDGFLADDVESDFNDEPSDTEDAQVPSLRNLLPVVREDLGYDGSREHLRKILHSLGFSYKKCKTDRSALIRKPHLAAKREQYLKIIMDNRNLPQELQKQIIYIWMKEGPSQENIPDFRLSAASAEEGKNVGDSDLGDLSTPKPPKSRRRPANDIVERQMSSAFGQLTNMLAKRQKENQPPLTEQDDCELYGKLLTHKLRELRPDDRKLMMYDIDTLFVNRIKEKQRAVEKYVSDCRKDFIEPGPAPPAVHIANTFPSKVSSDPKVTDIKALRYTPDGDVFFKLRFTEEWAVLPQRKSSAITALPFDSLRNQHLTKRKITKRKFYNLQYLKSTLPEDYRSYYDNLLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDF1</accession>
    <name>A0A835GDF1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_007590</name>
        <name evidence="11" type="ORF">HW555_008909</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000182">
        <property type="protein sequence ID" value="KAF9412640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000189">
        <property type="protein sequence ID" value="KAH9642458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDF1"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000019">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9642458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="17248" checksum="73683A3B5E3AD867" modified="2021-09-29" version="1">MAFMRIVGKACGFMGYAFQTACITHCTFEYVGDFVMCSGPSMEPTLQTNNILFTEHVSPRLQRLRRGDIVISRSPSNPKQNICKRITGLPGDRVRGNFPKRNQVVPRGHVWLEGDNSSNSADSRTYGPVPEGLIRSRVVCRVWPLDKIALMSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDG2</accession>
    <name>A0A835GDG2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDG2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000373">
        <property type="entry name" value="Protein still life, isoform SIF type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="23380" checksum="3219B8021FCCC9DA" modified="2021-09-29" version="1" fragment="single">RLWAEVFHVSASGAGTVKWQQVSEDLVPVNITCIQDSPECVFHITAYNSQVDKILDVRLLQPGTRIGQASECFVYWKDPMTNDTWGLNFTSPIDAKQFRECCSPSFKFSRKASSSYSLKLEPPGNKQKFKAKRKPLSTPASPNRSSLTYGREPQCTCMTQEQYARLRAQDPRYHAGATGTAGRSDKVAAATSSTSLYDNVSNSQPAHQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE89</accession>
    <name>A0A835GE89_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_006272</name>
        <name evidence="14" type="ORF">HW555_007831</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000140">
        <property type="protein sequence ID" value="KAF9414166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000888">
        <property type="protein sequence ID" value="KAH9628903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE89"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000073">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000004">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9414166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9628903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="372" mass="42672" checksum="144E0116A61AE5CD" modified="2021-09-29" version="1">MASVAAWLPFARAAAIGWVPIATHPLPPPPVPKDRRRAEDEKLLINVSGRRFETWRNTLEKYPDSLLGSTEREFFYDEDSREYFFDRDPDIFRHILNYYRTGKLHYPKHECLTGYDEELAFFGILPDVIGDCCYEDYRDRKRENAERLMDDKLSEAGDQSLPQLTDLRQKMWRAFENPHTSTAALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAILPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNEQDTNFTSIPAAFWYTIVTMTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEN7</accession>
    <name>A0A835GEN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pupal cuticle protein 20-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEN7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032660348" description="Pupal cuticle protein 20-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15794" checksum="4E195206F84EA28D" modified="2021-09-29" version="1">MFQLFVCIAIVGCVGAARLDHLVPSGYAGGRAGFDATPYHYENVNNGDGNYRFSYDTPEGTSAHESGSPRAQGPEGPAVTAEGGFSFRTPDGQQVSLTYTADENGFHPTGSHIPTPPPIPEAILRSIEYNRQHPSPDAGSFNGGRNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF05</accession>
    <name>A0A835GF05_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000096">
        <property type="protein sequence ID" value="KAF9416111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="23759" checksum="B857BE1774A89E57" modified="2021-09-29" version="1">MDGYGNFKWFLKPNFSFSFLKSGVKRRRSIASNATSTTRVDGLLLSVTERKQDWYQVDSTASVSNLVANANSDESSDSDHLDRETFISTMYHQLIQNLPDFQSNETLPSHPLHEIFAQGTTSPNVTTSTSTTSSSIALGGGGFFHDQDEYYSREDNIDSSQIERPYSELSSEGAQSIDASVQRMQDPQNKKRDQPYTNPHQNRSQRYYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF34</accession>
    <name>A0A835GF34_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_003685</name>
        <name evidence="6" type="ORF">HW555_007324</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000897">
        <property type="protein sequence ID" value="KAH9628731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF34"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF55">
        <property type="entry name" value="GEO08227P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032829333" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9628731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="16854" checksum="A81EE8A008C9AD29" modified="2021-09-29" version="1">MAVPRVILFAALLATALADDTTFVNCAESDPNVCQVSAVRITPCRNPGKSCTLKKGTDASISFDFNPNYSASNLKTYVYWDSGSADLPFLGFGSDNACTYTSCPSVAGQAQTLNYSLHLHKKLPSGNFKLKWKVWDDDQKEHVCCFTTDIKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF98</accession>
    <name>A0A835GF98_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF98"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="951" mass="106588" checksum="1C76917525DAE1B2" modified="2021-09-29" version="1">MNTSVEGIIVNNCQYAPIYVIQDPGATQGNTYVLASNNVEAPKPVSNNLKTFYENSGNIENGLINTDTGVKLNVVKKKESVLIGNNLKLASFLLPKNENVNKQYVVDNFVLKPTTTTTASNPIPINHPLNTVPKIDIDRKIVKLKEVPIINRHRPDKVLPKIKPKENTPSPTRSKHTSVQLIKLGETYHSLNHLSADQIKMVNQALKMFNDPDKSVPEPTYDPVTNTKYIYKVVSPKDLTVVAKKKILLKDRKHQLTKIPKRIEAEKIVKHMPPEKIVKQVVTKEVPIQKEIIEEEVEPPAEAKVTRSGRKVKLPKQILPEGSPQKTKKKSGTIVSCFQCCTDFGSLYRLQKHYENHPTHIPAKIHSNLFHCLLAIIKSGSEGNKTNIFIQQLEQLIVKLKSLLPCLLSKVEGTDGQPCTINEDIGRLFGMNPGKYNIDVEALNCVKDKNGYCIHNPPKITQLNKDQIKSPHLLKNIDEILIPENETENCARINSVAKWPTVSKRIWKLKQKTNEQQNAKKMRLKSEGDTLIELGTEDFNFPKDEKNNFNAASIIPDNNIETAEIIPQAEVAKLLESKRDCQVNSNSVTEQQTDDTTMNELNKPKTNYVKFHSAHFDIRSSPIKSSSTVFRKFQINPSKMASYDGQVIRSLEMVNKPDDKDVPPKNSNGLPNSENKTQQNRENRVHISTNPNLSVRRDLLDTNNSIHLSIPDSLLDSLTNSNGDHVDMSPNNGLQLHSLTDSNGIQHVTVVNSENGLDVDMLDSDNDIRLTKPTSPHDLHNEMPNMDVGVDTAISNSSKNVHVTIDDTNRRLDVNLPNSNSIQYLVSNSGTTLHDLFKDDVDLECKDSDVIDPDLKDWIIGTSEKSEDGFSKSSLMEPVLLHSEKSLDSKTLTQCNDMPTLDDSSDNRLLSSQGESVLNFLDTLGNDLYPETEIRNNGVDFQLDLFAFHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG49</accession>
    <name>A0A835GG49_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_007381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000124">
        <property type="protein sequence ID" value="KAF9414801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000004">
        <property type="entry name" value="Cyclic nucleotide-gated olfactory channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000058">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF7">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="977"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1351"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="945"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1356"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9414801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1438" mass="159157" checksum="7C398CF32A28E917" modified="2021-09-29" version="1">MLMYVFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVISEQGRVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPEAQEILQTLGRKRLQEAKNMSKKCKGRKPRQDAKTITKNLKGEISPDKMSGDDSTSKRIVHKLRSDVKDNNGETTSGSKDGEKCISPIGAGLPLLSRLKLLKEKQDREEKVAKQRHSTSSVLSLTPQPTPSTSSAPDAEPEVIGAGLPLIQRLLLLKAKEERDKNQLTPTMSNQPSSSDTISPTSIKSPLSPTIKTLSPIRKGSESSSPGKLQSPTTKTSRKNSSGSSDGTSRPKVSFRDKILQVQSDGTAVCQPLNKDEKPAAVVEPTPKTESNLISIPHSVVSKIKSPAKAVGSTFRDKLKLLQGGPKDTDNASIEKAKSASLEKAPVEISPLPTTEAKEEPKSKKPWTKLKKAAILGESKSQSKSSLEEKKDESINTGSEKKDEGIAEAVVNICVPIVTTAELKNVNNVTKPAETKTHMSPGMLLPKVKKYRSIDDLSPEYGGLPFVKKLKILNERQKLAELEKVVKIRSSSLDCTSSSEDLLCDTLTRSHSEGSTMDKRKFKRKSIDSCRSHESNETLERRELKSILKKLSEDVTPAESPERSNELKRLIRAPTLEGYAARHSKFAKSVTFHRHTLPSPPGSAPADYQNDDVFTMPEVNISSIPQISPPPPPDVEVTVPEVPNNQIARSAEPNAPTDYGLNIRAEYEFQQNIDPMIDLKSLRPEEIKVPSEKPKLTLISAVANQRKLLRGSIEEQEYFGEVLLGIKQVIQGHLHDVQGKFQERFNSLENEVRKRDEIISQLQKRIQELEKLGLSGMSPTAQLSGETPTIVPESIEPTSTSQPISKSASSGSEDASAAEEGFMRGDSLDTVFATSPPTASADEAERDRSPDNEAAGAKETLSPDDLTEENLRELTEGIELSKLSYAELQNLAVSLSRTDKTSSSKEQWTISKSKRLDLNLDGKAGTYSRKRAAKLKQRKSWEDQSDQESMEMQDLTRPLSPHTTSEDRSLLSPEQSSLRSSRRHFHFFGSHLDNTKSKIKKTLSVDTGMHHTGKNERSICYSEGRPRQHRKFSLGSLFHRTPAQKPTNNCNDVVLDMGSDYSWSDAGSTSSSSDSESLPRTPMFEEFVENNSRRGRASSSSHGSSSPIRALPGSGGDWEVMMLADELEKREREKEREDARRHLYPTTLRDLEESISDASQRSLETSFTEQTSRIGREPRQRRVGSVGEPVQPDSSFRQSRGLILRAASLDRETTPTTSAGTRRFGSLKSASTDSHKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGJ7</accession>
    <name>A0A835GGJ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_005431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGJ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="393"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9417508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="701" mass="77261" checksum="68B149ACBF2C1CA9" modified="2021-09-29" version="1">MSEERVASEFPTSLVLKRNRIAYIEEHAFANTPALRVLRLEENLLSEVPAALRLLPLLEDLSLASNRVEEVAPGALQACRRLARLDLRANPLPRLHAHALDHLPHLTTLDLKLNMLRRVPDLRGCGELRVLDLSGNEIAALDGQSLRGLRRLHDLLLARNRVRRVPADAFTHTPDLQVLNLEDNMIEHIDMEAFVPVSKLEDLNVGNNEFPWLPAAGLQRLLHLKAHNNPRLRRFHPPAALPRIQTLVLSYAYHCCEFLPLMEDQGPEPAAESPSDLVILPPQHIDPAAWANATDIWAHYCTCRAPSVPPPLPARHYIVLVSAVNVSELGGAGLQAALDGWAGAGAVELGERDLPRRVHCLPLPGPFLPCVDLFDWWTLRCGVWAVFLLALLGNGTVVFVLICSRSRIDVPRFLVTNLAAADFFMGIYLGFLAVVDAGTLGEFRAHAIAWQMSGGCKLAGFLGVLSSELSVFTLAVITLERNYAITHAMHLNKRLSLRHAAAVMAAGWAFSLTAATLPLLGVSDYRKFAVCLPFETSTPVALGYVVTLLVINGVAFLVLLGCYLKMYCAIRGSQAWNSNDSRIAKRMALLVFTDFLCWSPIAFFALTAAFGVQLVSLEEAKVFTVFVLPLNSCCNPFLYAILTKQFKKDCALVCKAIEESRVTRGIGRCRHSSNFSNRQTPANTNSLAERSIRKLPRATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH49</accession>
    <name>A0A835GH49_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH49"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37445">
        <property type="entry name" value="PROTEIN CBG24663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37445:SF3">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="1">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="35753" checksum="CC654A85A16DEC2E" modified="2021-09-29" version="1">MFTCASCGFQHAEGPVCSVCKQQYDYQCSGVSEAGYRRLGDARKSAWRCPKCKSSSSLSPLALSPQPTSQLDRMQEQLNKITSDLTPLATLAADVKSIKSELTGLKDSMEMAHEIINRFSEKVNAVESKVTKLENAASQVTVLQAHIDRISRDLQDREQWARANNAEIKGIPQKSNENLYDIAQKIGSLCNVTVRKEDINYIARIPTRVPNAVKPIIVAFNNRYMKEEFVSSSRKSKQLNISNLGFSSSANFYVNDHLTTTNKSLLSKARTLARDNNFKYVWVKNCKILAKQSDTTQTFFIKCEKDLQRITNRQQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH65</accession>
    <name>A0A835GH65_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="234" mass="26590" checksum="1C80E112D1153855" modified="2021-09-29" version="1">MALLMRQVMFRKFRKLIQNSITQEFCLFTLYVLSLLVPIEGQGKTQQIMTEIQTLFKEHCVVPDVINIPPSELLTIKYPSGSVVTTGKELTPTQVKDQPVVQWAAKEEEYYTLAMVDPDAPSREDPKFREWHHWLVGNILGGHIGKGEILSEYIGSGPPKGTGLHRYVFLVYKQPEKCDFSKIPKLRNNSGEKRGKFSIAKFATEFKLGSPIAGNFYVAKYDDYVPKLYAKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHM2</accession>
    <name>A0A835GHM2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="98" mass="10360" checksum="A905C4CF9C470078" modified="2021-09-29" version="1">MKGGLCVIYSSLLTISVLSSCALFILVVSEALQGEGGVDTKVDLSGLHNVSQKVEIGGQEVRGSQVPPKAQLVEEQKKEDQEMIIAETLSLNSVTTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHN7</accession>
    <name>A0A835GHN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000117">
        <property type="protein sequence ID" value="KAF9415127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHN7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032883249" description="Cuticular protein RR-2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="19097" checksum="9EC09D43D4320465" modified="2021-09-29" version="1">MAAKFVIVALLVAAAQGSAIHGADYTSFSYGVSDPHTGDVKSQHETRVGDSVVGQYSLLDSDGTKRTVDYAADAHSGFNAVVRKDPALYAHAAPVVAHAAPVVAHAAPVAYAAPLAHGYATAPLAHGYSHGVATYGAVAAPLAHGAVAYGAHAAPLAYSAGVYGAHVAPLAHGAVAYGAHGAHGLYGAHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHU8</accession>
    <name>A0A835GHU8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032934603" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="205" mass="22756" checksum="293AE1415CC6159F" modified="2021-09-29" version="1">MILFITFLCFLASSCIARPNIETVPQNVVTVPPNCPEGQQWVNGQCRDVWRVTAAPSNLITVPANCPPGQSLVNGQCRDVWIKTLLGSYYRDYTPQNVVTVPPNCRPGQQWINGSCRDVWRSGTDNKNVITVPTNCPSGQEFINGQCRDVWRSLLNLNNIGDQLQVEEVEGLNSVNRNVITVPNQCPSGYRPDALGNCRPILIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHZ1</accession>
    <name>A0A835GHZ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHZ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9444" checksum="3A0AA7859F08D8FC" modified="2021-09-29" version="1" fragment="single">MSQKAPSKNPKSKSSEEIFSGFQNLRAEQRQLANKISELEMDLNEHKIVIETLRGVDKTRKCFRMVGGVLVERTVAEVLPELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI85</accession>
    <name>A0A835GI85_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI85"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="53"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="49657" checksum="AA41072EBF35AE14" modified="2021-09-29" version="1">MNDEKQPLLTGPNNAIESVEQTVELVTDPASPSSNSEKPKGDYHPASERCLEHPTSNFDTLIHLLKGNIGTGILAMPDAFKNAGLVLGVFGTLIMGAICTHCMHMLVKCSHELCIRSQKPALSFSEVVEDSFASGPVSLRPYAKSMKNIVSVFLVITQMGFCCVYFLFVATNLQDTMRFFNVNLNVHVYLALLYLPIFALAMVKNLKYLSPVSLVAFIMTAWGLVITFYYILQDLPPTHTVKAFSTWHQIPLYFGTAIYAFEGIGVRPFGGWNGVLNTGMVIVAALYTAIGFFGYLKYGERVQGSITLNLPNSLLAQSVRAVMAASIFLSYGLQFYVPMNIVWPYVKSKLTSEQALKHGEAATRFVLFSITFLAAALIPNLSGIISLVGAFSSSALALIFPPLIEIMTFWPDQLGQSNWKLWKDIVIMIFGFTGFVFGTFINVKNIFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIK6</accession>
    <name>A0A835GIK6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIK6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF171">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032607758" evidence="5">
        <location>
            <begin position="20"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="648" mass="73597" checksum="523ABBC41EE74B9F" modified="2021-09-29" version="1">MRALCFLTFLFFIFKNGSAQDVYEELMNEEVLKLIQLCEVCTCSEIADIDRTHIVLYVQCSEFDRIGNVADLDKIAWPLNPNGLKISATFDGLGLSTLGKLPPNSQVETLKFTNNAIKAYWPDPFSDVPNLKILSFSHNELTEITPDLFTNIEGLEDLDLSHNKLSDFNPLDFKHLRHVKKLSLQSNNLKKIPLDALQPMTSLEELDVSKNGIFDLLLQRNDVENLARLKRLNLNDNRIRSITKDSFPANNSLELLDLSNNIIEIVEEESFLTCTNLRELNLAQNNITLLFALPPTLQIAILKVNTLFHWPKFPSGIKYIDLSYNRLSELYDESAVNFDSLEVLNIGGNQIKELNIEKKLPSLYILDLSYNLITEIPKTISTQFFPNLEELHLDGNPIEAVYFKNIIAVKSLFMNEMKALSVVDEKAFSNVVGRASDETENELNCFSLYLSSCSSLVEIKAGAFDGTSLCMLDISKNNLTYLPKTLVEWSSVSEGVNLQHNPWDCTCDMQWVVDDLLPQMYAMNQSHLLAELRCGSPRAFEGLRLVHWYNWTERAMCSEQYSRTGMHGNYMLEPSTEDGLQKFSSLTIILGVCIIVTLLIAIALAVYLVKTRKQYRVRRAAMRRKRQSAADVTNGHKEQFTNLNTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIX4</accession>
    <name>A0A835GIX4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIX4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="162" mass="18039" checksum="02BB45D8F563C790" modified="2021-09-29" version="1">MAGEQDSGNPTEAVANELLDKIILKQLHLMEEKMRCELNIESSIKNGSIHLAKSRYIMGQSSVSTARLPTESSPDFSASTICETTEEDGVKVMKVIENDAENTVNPLRWFGVLVPQNMHKAQSIFQNGINFVVECVNVQLQLQSNLKLINMLKQYIGSNKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ71</accession>
    <name>A0A835GJ71_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurofibromin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000078">
        <property type="protein sequence ID" value="KAF9417068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05130">
        <property type="entry name" value="RasGAP_Neurofibromin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000014">
        <property type="entry name" value="Neurofibromin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000015">
        <property type="entry name" value="Neurofibromin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033016646" description="Neurofibromin" evidence="4">
        <location>
            <begin position="31"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="1555"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2478"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2696"/>
            <end position="2719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2484"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2525"/>
            <end position="2541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2741" mass="309506" checksum="59CE5B898D2F0B37" modified="2021-09-29" version="1">MLIKLLSARLTFSLGFFFSSLGSMEPGVWAAGADRGSWLIGKDSNRFLQPKQLPYKTGAQNLHSRINEEQCKACLVQISKHRFSLVISGLTKILQRVNELYQPTIAMGSNRPQTEQEKGYHDSLVIVLDTLEICLSSQPKDTAKYDEAMNVKILLREVCQFIFSIYYYTDMRNESTVNNTLLRQLASKVLFALSLNFFNAVFNRISARLQELSSSSEENPDFTDIELIQHVNLDILRLIRLLTESIQKYKLLKKNAHVVLTSSLEKAIWNWMDTYPQEFAENQCRPNDELSKCCDLLFDLLQDSFSDNKKSRVTVWPLQIMLLLLNPKVLEEIVNADSGAPCSPRHTKKKLFIDCVKRGLSPSNNSKQMTEAAVVTCVKLCKASTYLNIADSGNVTFKLVKSVINDLKSLLFNPAKSYIRGNLVSGYSEIDLMTDCFVSLFRIMPHNNDALKVCLNLTTHISYHYVIINSLLRIIKQPRLPWWPQIELLYPRAAELRAMFTDTSNKATQGYVVHTPLRMISLSLKSKEVQSKFNKSEEMPAYRHLLLCIVKLIHADPMLWLSNPGRSSIEIQSSTTELMNGLVSLVHQTGMGEISQAAMDAILALHRPDRVHMWNPEAPLNTFWDISSQVLYNISQKLIQRQICNYREVLRWLRDILTCRNEFLAKHKEYANVGSQIPISKQAHIKLEVVFFMCLWSIDTDVVLVAMSCFALLCQEADIRCGSDEITTQCLLPNYAVFQEIAHTSTVLTTGSAALQKRIMALLRKIEHCVNGVQPVWEETFRCWDSLCKLLQKYPKGQGDKVDDCQMEAIHRAVAKRRVSHHTSSEHDFEMQIQEWANITSFLCALGGVCLQRRPTTSWSHLHGHADSRKYNVLANSSQEVQYCPVTQFIGQLLRLLLCSNERFGQQIQTHVKELVGHEMSPALYPILFDQIKAIIDKFFDQQQQVMLTDINTQFVEHTIFIMKSILDIKKSGQPNEHLSTTSIETLMLSIVRYVRHLDMTVLSVHIKTKLCQVVEAMMRRRDDLAFRQEMKFRNKMVEYVTDWVLGTSHQIAPPLRADASSITRYLVCCRELDQACMEAVASLLKGLPLQPEESDRGDLMEAKSQLFLKYFTLFMNLLNDCNEVEMAEGPGRLETLRNATIQAMSNLLSANIDSGLMHSIDLGYHRDLQTRAAFMEVLTKILQQGTEFDTLAETVLADRFEQLVQLVTMISDKGELPIAMALANVVSTSQMDELARVFVTLFDAKHLLAPLLWNIFYREVEVSDCMQTLFRGNSLGSKIMAFCFKIYGYGYLQNLLEPLITALLDQAEERGDISFEVDPARLDPNQDIEMNRSNLIDLTKEVFDRIVGSADKFPPQLRSMCHCLYQTSVGAVGTVLFLRFINPAIVSPQEMGIVNRPVPPHVKRGLMLMSKILQNIANHVEFSKEQHMLPFFIQIASDCESIDQTSHNLSFISDANVVALHRLLWNHQERIGDYLSCSRDHKAVGRRPFDKMATLLAYLGPPEHKPIESTSSLLFSSYARWSSIDISSTNFEEFIVKHNMHKKEEFKSIKSLNIFYQAGTSKLGNPVIGEVNADLLIYHVILTLKPFCQQPFELIVDFTHTNSDNRFRTDFLQKWFTVLPEVAYINIHACYIYNCNSWVREYTKFHEAILAPLRGNRKLVFIDNHSRLSEYVEVEQQKLPGATLALEEDLKVFNNALKLSHKDTKVGPTALQITSVEKTKVLGLPVLLNDVYYASEIDEVCLVDDNQFSLSIINESTPLSFIHNDCDNIDSVTVHQKIRPKDVPGTLLNMALLNLGSCDPNLRTAAYNQLCALTATFHLKIEGQLLETSGLCIPSNNTIFIKSVSEKLAHNEPHLTLEFLEECIQGFRGSTIELKHLCLEYMTPWLANLVRFCKPSEESRRQKQVAQILEKLITLTIEETEMYPSVQAKIWGSIGQVPELIDMVLDSFIQRSVNSGLGSPMIEIMADTAVALASANVQLVSKKVIGRMCRALSKLPNNILGPVTPATVVDKTCHSPTAMLEQHMMWDDIAILARYLLMLSFNNCLDVARHLPYLFHTVTFLVCSGTVSMRAATHGLVINIIHSLCTCTTPSFSEDTQRVLRLSLDEFALPKFYQMFGISKVKSAAVTAFRSPYNRHTNDWYSEHSYATCSESTSTGTCAGATHTDRERLPLQSLEIITDALLEIMEACMRDIPDCDWLQTWTSLAKSFAFCFNPALQPRALIVFGCISKNVTDDDMKQLLRILVKALESFNDLALLEALIMALTRLQPLLYPASPIHKALFWVALSVLQLDEPTLYAAGLAFMEQNLHTLESQGQFQHKTLEQVMMETREPLEWHFKQMDHAVGLSFRSNFHFALVGHLIKGYRHPAAATVSRTCRVLVKLLALVASPHTHRDKFHVTPHTVAYLTALVCVSEEVRSRCHVKHSLPKWLPDNCDHYCPTAELHQSSILIQPSSSHSSCHSRRQKSWDVLDQAAISSAHGGKSPTLQSSSSGGHSPHLVTVPHQMVEDDGRGSPGSTDDTERPSSTKSGDSDYPETSTKQASTDKDTSSPESNSLLDPAVLGDFTTQALVLTVLATLVKYTTDEDEIRILYQYLAEGSVVFPKVFPVIHSLLDMKINHVLMHCHDQLILSAVQSIIQNMIASEDASQQQLHYMQSCGFGGLWRFAGPFTKNQCTAESSELFVNCLEAMVETCLPGGDEALTRAPPPDPDHPDPRTPTGDVVLRSSRHLAAGRRVNENVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJE9</accession>
    <name>A0A835GJE9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="216" mass="24152" checksum="2554732AC61C2BB5" modified="2021-09-29" version="1">MKTPRKKFAKIHRVELSAQKVISEFCEVPIHPDSSGQVAETSGNKAVTPKLQLVISLRRAKSNDALIRQIISDEESSLASSAGQTDRPERKSMLYRTPRRGTGVEMDLDTRKANNLLQKGKEALEAAGNMKRECKTTTYECLQGLYETAELSLMRTDLSDTKKEARGIREWLGHETLNAFKGIKEVKEEVKTAKLLITKEHEKTRLSTVGTPGDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJJ2</accession>
    <name>A0A835GJJ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJJ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="39141" checksum="EC2E91C64E7B0FF2" modified="2021-09-29" version="1">MARVNIPTFTMNDGNKIPALGYGTWLGMDEKEDAGPSKPFSFEFSAAGMPKMMEALSYAIDIGYRHIDTAHLYRVEPEVGKIIDKKIKDGVVKREDLFVTTKVWHHFHREADVEVSVRGSLRRLNLDYVDLVLMHWPMSISQDGVDEKIDYLETWRGFETVLKKGLAKSIGVSNFNVEQMKRLLANCKVPPSTNQVEVGKELVDYCQANNVLIVAYSPFGTMVPSRSAPNSPEPKLNNPTMVAIGKKYGKSVTQVTLRYLFQRGIVSIPKTVTPSRVVENASIFDFELDKDDMATLAKFDNGFRTVRPFFWQDYQNYPFEKIPDKMEIPESLRIWKNGLNLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJR8</accession>
    <name>A0A835GJR8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJR8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="455"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="706" mass="81572" checksum="78A17CFC25E2D4A9" modified="2021-09-29" version="1">MDNIDFCDSSGSDIGGEEMVQDDDQLAKDRKTKEAEKRGRSDSEEIIVDDEGYITVRDKKRAARRSRQTPNNLEINENTNTNISVSDKIIVCVTSNDILPKPFGMAKLLKSENIEGILKIQYKNPYKISIQFEKRKDAENLMSCSKFQSLNYRCQFIDEINLSYGLVKQIDLEIEEKEFLVSIECEKELVSVKRLKRQSDSGEWIQSETMRICFKSSILPPYILIYGCRFKVEPYTFPVSQCSGCWRFGHLIKSCPTKKIMCPKCGGNHGNCETEVFKCINCKGPHMSLNKSCPIFIKEKTIRQIMCEENCTYRKALLLYLNKSKLQQDNEKMIIQDNVTQTSQIPLSINKEKSYRDVLLTVHNHSEHLDSLPQKAHIGERIRDMTMEEHENLQFSSKPKRKINRRRKKQYEEDEVFEVGQNSNEDIEDTDDQQKETCSNIFYLKRLWDKLKEIYFAKSSISVKIRQSDWDELFSIYPNKTLIAGDFNGHHSNWSYKTDGRGNQIMDSALEYGYIPINDGSATRLSKVVAERRLALKAFRRNPSPANLTVLKYKTLIANLEIRQTKTTCWQEYCSSVDGKVTSSQMWRKMKWIKGIRQAGCYVSMDKKTELLRNLAPDTTLNPKPPFTSNNALLESEFTLQELEACIKKKDTAPGDDNVTYSMIFNLPIVAKTYLLRIYNCIFVTGCIPNEWRDIKVIAIPKASIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJU1</accession>
    <name>A0A835GJU1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="40340" checksum="20DE4D01C663EB75" modified="2021-09-29" version="1">MAPWLEFPYEMKNITGEDDKILRKCLLGYKKPFVRCGDKGFVMAGSYRKHAEFIYNFQVRPDDVWVVTVPRSGTTWVQELVWLVANDMDFKTAKDKPLYKRFPMLEISTHIPEIAVELIKINFFNLGNFQGLNEAVKEKSWKTLEKAPSPRFIKTHLPLSLLPPNLLSTAKVVYVARDPRDVAVSYYYLYKMTNKSLLRANVTHFWEAFRRDLLPWTPIVEHANEAYEKRHHPNLHFVFYENMKKDLHTEIGKVCKFLNKDYTDAQIDRLAEHLSFDSLRKNKNVNNTTTKDSEIQFIRKGEAGGWRSHFDEKMQLQAEEFLLTRLAGLELSYPSFPTHEITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK32</accession>
    <name>A0A835GK32_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Golgi SNAP receptor complex member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GOSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK32"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24352" checksum="E99394978B3B1CF3" modified="2021-09-29" version="1">METLYHQTNHLIQETSELFQKLERDPTNYESIENAIQSKINTISANCERLDIYVFKTPINQRPMAKMRVDQLKYDNKHIQASLNAAQNKRIKREQELKDREQLLSRRFGHDHTAINVDYLAQEQLSLQNSHRNVDEMLHTGSNILETLKYNRETIKGAHRRLIDLANTLGLSNATISLIERRVSQDKYVLFGGMFVTLTIIVLVIIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK74</accession>
    <name>A0A835GK74_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="11917" checksum="216DF02E35F09A06" modified="2021-09-29" version="1">MTNLSLNNAGGRTAGFRDLELPFRMKIGFPQRRANGVAYLERRERRAQNNDATTEGSFKLSNLIMTAFTSVTKIDDVCLSHKSSVLSTKLSQGKGWRNSCNNEQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKC7</accession>
    <name>A0A835GKC7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKC7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032724443" evidence="2">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="29223" checksum="239893D49F02DC42" modified="2021-09-29" version="1">MRLSIILLFNIRLNIAIQYEPETTLSPRQRLRRLPQQQNILVYTKMATDEEKCKLNKLLQGLEVSEVKLTERCSDLVKTFQQRFGAEVEAESNQESEKIYDDLTDNPYKVDPQLLEENEKKLRELLNESKRSKKANSEGVLMTSADDKRPWRTNSSKEKLFRVDSELKRHMKKSSQMIVPLPEHEMQHLVKECREEGSVAPAVGANRLRETVDAAKKNLPNFQYKKIYNSTATSIMPQAHTVQAQPAQPKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKV7</accession>
    <name>A0A835GKV7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="63" mass="6958" checksum="39A19018E05A5EF8" modified="2021-09-29" version="1">MKSRSTTPRPQAACYPTNREVHPTSLVPHGAHSRATNIFDWKPLHEEILPGKLPPSAVSPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL32</accession>
    <name>A0A835GL32_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL32"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="139" mass="16659" checksum="63D0B18D187F2CA2" modified="2021-09-29" version="1">MNVSRGRVNWKRPYDPLQFLKFIHRVNRCTRCVSYVVISVLIKHEHSLELRYKGISPFVYVESKPLEDTKPLEETKQMAPQIDDGEMMEGAESQNPFLPRFAMKKLRERSEKANAQRRNYQGWRRWNAPQRVPCPDRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL45</accession>
    <name>A0A835GL45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="20162" checksum="787EE273610D6EEC" modified="2021-09-29" version="1">MGVGDLVKRWWWGGDPDERNKVSGMSLRDVYNVQKSWAVINANSNGNGFLMFFRLFEAEPETKTFFKNLAHIHTEEEMTANVSFRAHIINIMSSFDNSIKNLDKPELVVAWMQKLGDSHRRHRIEKRHFHVFKDVLVNILQKDLKLEPEVVESWDRYVEFIYEHLLSRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL56</accession>
    <name>A0A835GL56_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL56"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="185"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="33625" checksum="3A5A1AC83AD932E7" modified="2021-09-29" version="1">MAARGTQCFLTVARKYSSSADKNVAFLGLGNMGGFMAANLAKKGFAVRGYDPSKEALAAAAKNGIAEANSIAAAVDGADVVVSILPSNKVVLDAYLGKDGVVQHARKGALLIDSSTVDPNVPKQIFPVAIESGKGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPFLKAMGAKQFHCGDVGSGQVAKLTNNMLMGITGMATAECMHMGIKMGLDPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASSMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSYVFQLLKEDAEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL60</accession>
    <name>A0A835GL60_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL60"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7563" checksum="62FCD8F1C86BCA57" modified="2021-09-29" version="1">MPPTKDYNTKSSFGRSYSNNGMTMSAKVYHPATNLMPLTPPQSPTGVAPSFGSGKSSSSTWGRQNSNGKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM9</accession>
    <name>A0A835GLM9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLM9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="222" mass="26040" checksum="E24D24A832736603" modified="2021-09-29" version="1" fragment="single">DFHLHPEEYTCFLNCEIENQEASTKSLKEGKIPTPIEEVKKQLSLEEALRADKQYDKNNPKSVMIDKLIGEMIAVQDLPFHFVEGIGFRRLMSAIMPKYNLRGRNFFTNYVCNDLYEKVAAEVKKIIKEFKHMTFTTDIWTDPSANVYLLSLTCHGINENFERKSIILKCETFEDRHTGDIIAEKYECMLTEWGIARDQRRRVKYEKSHGNIAIPRYRLHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM28</accession>
    <name>A0A835GM28_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deltamethrin resistance protein prag01 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM28"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031973">
        <property type="entry name" value="Deltameth_res_prag01"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16020">
        <property type="entry name" value="Deltameth_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Deltamethrin resistance protein prag01" evidence="2">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14415" checksum="221EA1D91CD6B689" modified="2021-09-29" version="1">MLAKILGFRRGLTSAIRRGYPCGNLLRSGFHPNCGIPAVRVNPVTITPTRSYRCDAHMNELPVPCLPWEPWYSDKQSLYNKILLGGILWWLFSLGMMIYTDSIYLNWAPPKQPGPPSDMVEECDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMT4</accession>
    <name>A0A835GMT4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_003878</name>
        <name evidence="10" type="ORF">HW555_002599</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000215">
        <property type="protein sequence ID" value="KAH9641752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="279"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9641752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="330" mass="34484" checksum="567432E18D6475E3" modified="2021-09-29" version="1">MFSPSSRHLLFSTQLRRLQSTLVVAEHNNEVLSPATQNTLSAAKKIGGDVAVLVAGTKCGPAAQAVAKANGISKVLVAESDAFKGLTPETLTPLILASQKQFNFTHILAPATAFGKALLPRVAAKLDVSPITDIIGVKDANTFIRTIYAGNAILTLEAKDAIKVITVRSTAFPPEPLEGGSAAVDKAPEGDYKTDLVQFVSQELAKSDRPELTSAKNIVAGGRGLKSGDNFKLLYDLADKLNAAVGASRAAVDAGFVANDLQIGQTGKIVAPDLYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVSDYGLVADLFKAVPELTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMY8</accession>
    <name>A0A835GMY8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="14046" checksum="A337B8D2AC6BDFB8" modified="2021-09-29" version="1">MEILGQHLRTCTSLAKLTAYMEPKQDKHKSIYSKRKQAKTFSELKNHSKSGDYCTPSAETYRKIDELRTRYDYNKDKASTFTNTLTVVWANTTQAWNVFYFLPPKLSSSPTLYPHMDSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN09</accession>
    <name>A0A835GN09_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="137" mass="14933" checksum="BC3949943CFEE7D0" modified="2021-09-29" version="1" fragment="single">CYCCGLHVMPKRSDNRQVGAGSGQAARVLVEAGSHGRDLSDACDLQKYPRIKRPPGATYKGRARHRAVLLSNLATTTGTSCAACLLCRAPSLRAAPALSHHSPQRPPIGNGYYFEKQKKKSLCIGNYVPYNKCQLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP32</accession>
    <name>A0A835GP32_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002275">
        <property type="entry name" value="ATP-binding cassette, subfamily A (ABC1), member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="488"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1557" mass="173597" checksum="B4B48749A5CE6488" modified="2021-09-29" version="1">MNTRVLSVLMWKHAMVRKRRFIQTAVEFASPIMFFLLLFAFKNHITRKPSADHRDPVANTEVIPITDFPVPHWILYYPDTPLTETLMNEVGLKLNLKKLDNFPDYTVRGYFPCTNESLIAEFASKMRLREAIVIFEKMSDETWPDRLNYTIRMKDHFGIDSYESLDDTPGPHKMFGRKYETFMRIQWAIDMSYIKLLTSTEVPQALSVQEFPYYRVENNESISIICLLLMTVCWISMMLPFVFLMGRLLHERATGIQELIKMVGVSQNLLGISHFLNVLLSGLVFSIGGAILLKSTSNPLINNSNGFLIFLMLLLYFNTVMSMAFACSYISKGTQYVATLSVLAYVVLWIPARVKSDYDLPYMLTLASGLLPHVPMHWFWKEVAVLEMYGSGVYFSNMLSAKANYNGSVFLSFVFMLLQAAIFYCLTWYLSLVRPGQYGQALPWNFLCKTQYWSKNEVIPDTESEEENPMAQDPKFFEPPPANAEVGIKIVNVSKVYPKQRVLRNINLEVYKGEITVLLGHNGAGKTTLMSIITGMTSATEGNVYVNGKDTVRQRDEVRQNLGLCPQHNLFFPDLSLREHIMFFTLRGTYAEARSSSRALAARLGLEDKLGAACQLLSGGMKRRAQLACALAGGADVLILDEPTSGLDVETRRELWDLLLSLRGQRTVLLTTHFMEEADALGDRVAALHAGVLRCHATPMHLKRAVGTGYRLSFTTIGTPKEDAITNVVTSHVPDATLKEKTINSLSYNLPAASAKKFPTLFAALEAKRSELGIDSIGVGVSTLEEVFLKLCSDVDNTMSEDEVDGNSGPDISQERLTGVPLYLRQIKVLLIRQVKYAIYKKWSFLALQLVFPMITIIAMTHFTNNAELQRNPDGALRMSLDLYGDRPDHRVLLSLRSNDFDTKAFTEHFPRLKFEDTNDVADAVLRTGEKDVLEYNKYIVGVEMNDTDAKILYTTTVRHAAPVALNVLSNVLAARGLPWADGRTISTVNRPVPPDAAAPTKQGMPKNLITLVTWGMCVTFIILATNVNSVSLACKERESGARHLHVMSGCPAELHWAATLAAHAALAALSLVLPVCLAALLLDQDRTIDQPDLLGLLTPFMAVAQKMFSNSPSGLMHMALVTCGYLMPPHTLVTAVLQALNVGQINAMCHWMRSKQVCPGAYANENGLDVEKCCAGENPRCYFCIDDFSPGQNMIVLFLQFTVLMAMVFLTERGFFNGLVNKLANLRYQPTSDPQADEMVRAEKAYVSRAIKLPSKQIPDAMLVDDIHKNYVSILKKSVNAVKGVSFSVKKGECFGLLGVNGAGKSSTFKMLTAEESATRGEIFGNGYRLTRGNPHYLQTLGYCPQFFGLDMFQTGRDNLRLVLTLRGYDDKHVKEEVDNWIHIVGLEKYANRAVEEYSGGCVRRLGAASALCGGAALCLLDEPSAGVDVAARRRLWAALRTALRRGRSVIITSHSMDEMEALCSRIAILSAGRVRALGTAAALRAAHAHGHAVVFKTMLHYHINDTMRYSELFTELEALKAEFPNLIEDYSVTETTLEEVFLSFAKEQQAINESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPN0</accession>
    <name>A0A835GPN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NF-kappa-B essential modulator NEMO CC2-LZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051301">
        <property type="entry name" value="Optineurin/NFkB_EssMod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553:SF1">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B essential modulator NEMO CC2-LZ" evidence="4">
        <location>
            <begin position="502"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="206"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9422350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="661" mass="73957" checksum="14BDEE614507CBF4" modified="2021-09-29" version="1">MVNGDEDSFIILGTSPGSSLDMKCLENGLETGEVTLDKEQMEEAMKDLSDEANMAFKAHFKLGDCPSPASMMVASTIITDDRSTEELQKKFGELLDENVILKETLKQNNESMKEQFLLIASCQEDMMKTHVLHKEKFEETKGLVEKLRQENKKLKSEIAKLADTEAKSLVSSETGESVVATNVGDPVPSGPSSALEFVTSPDDDTINKLTSQLELVEKQRRQVIVENEKLTWQKESLEHIVDATSKERDDLKEKLKNAELLLSTKDTEHAAEVDDLKYTIQDLQAQVQSASNYGSISSEEVAKRDQQVHQLEGKIAVLQAELKTAQLKILDLETVKLEFTKLKSGISEAIRIYKDQIQDLHTRLKEAATTVFQPVRFSISSESENSSSEFASLMSNVKLYDKTLKHLADLLNALTHGMSDSLVQTLGLISSLHDYKLERVTAEQFKSGLTEIKQQMEKQHSTALNNIGQVRGTLSIFEGIFKDYSEVLKNSVAPKARVERAANVEALTAALVARGQELTALRAELDALRARHDDTDLLKAQMDLYKSDFEAERESRQKMASEKENLQTDVRTLQKRNQELTQQLEEVRKINPSVYRSATSTSRSSTSRGSSSTVRAAPTRPAPAQPATTGNMVFTCPKCMRFSCDQYKVMEDHFDFCLDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPN9</accession>
    <name>A0A835GPN9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPN9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="631" mass="69193" checksum="861547EAC6BDC9B2" modified="2021-09-29" version="1">MSGYLEIKYPFKSNLGLNPFKSWKRQWCILRPSPTCSGASLAVYCSEAGASAGSVELPLGSVVKRAKSRTRPHAFAVFSVNEPRKPRILLAAQSLHETQVWMEKIRTLLNGSKILDNEPLLKDSYSVSVVATELSRKCGLSTDTVVTLTSAGVLVARTQLATFLEWKHIKDVRLSDDDKNRTCVLTVDSEFSNGGGELKLRSPLAGALARAVRAALPPGPAETSAPRANRSPHKLSKSDGDLRTHTYSDTHMGDVRRSSWYSGPSEVSLDDIDLVMSKESKHIPAGQLSRYSGDGQLASATALAQPFNIHSVASFDDSMSDRRSLLSVASGIYEEIPDLPEGTDTNALCTITCDVPDGVFKALCAPLSEEPTYECVGDCVYATMRRRRPPPLPPRHPFSTLKPGMGWARLGTRRGAGGAAGGAPREHSVTRHSSLGSLPRAAGLPAPIPASHTNTLPKRQPFSVFRKRLKSDSRVTGSQKSETSKENKDVETKKKKFDFTPTRDIFKSFKVSRKMKNLKITSGTLAKGETKSCEFLDDTEHVQPNRCSKSVECLENDFEYEADLSIELTEDSMAALTLPQQIVDLLLGHEQMSKVRLKDQIENDYMPMSPIIPPAPMEHHYIVMSPRTNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPV8</accession>
    <name>A0A835GPV8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPV8"/>
    <dbReference type="OrthoDB" id="7683421at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="634" mass="72738" checksum="8DD8457421BE5462" modified="2021-09-29" version="1">MGGCRCTYRTCSSRTDGKTHMFHYPVFDKVRCHQWITNARKLEFLNLKVSQLRNRVVCQHHFKDENFMNFKKDKLTFDAVPTEDGPYCDASEADNAKNEQDDRQVFSISLDDIENEYLTIVDKKANFSVKYGDFLTNCELMDLNSLNTTNQTNDNSQIDLNDNTKLVPVIPKDLILPKKPVKCVRPQIRKSTRGKELKTTGKSILNNASVKENIINHDLFQDNSTMQPSTIELSRQSKIQPSDLEGDAINFTINVSEVPVEFCTAVGSDVKPDETKFTINHLNQLQLSEEKLREPSCKENQPQKPKINHELNKNNNQPVTATVLNNPNEKPNTNNSLLKETKKIKIISEKKIVNPKPIIGKLEPVSPTRILTFPNKKRFINTKAGADSVEPTVAEELPKRRERNPVLEANASKDNILEKSNNDSPTICLNEGIAATNQEKTILPKTKNASIITPKTSLLKNKIPPERVAAIAEKRKFNMKLRDIVEDCLDKLEEPQKTDYEKRPTLQETRLLQSKKRQVASHLSEEPQLPNVQEYTLAFLEARMKKMENNLLNKIEENSQKIMELKRAYAPSSSKKSVHTQTQVNEDVHKRYLYQELSKYLSQEANSLLYEELFINKYTKDMPKCSSPKRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ27</accession>
    <name>A0A835GQ27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="6">
        <location>
            <begin position="68"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30766" checksum="979910E49C5C0CA3" modified="2021-09-29" version="1" fragment="single">GPWLEATAAAVPWSLGVDIAIWNAVGWAGWGEWGACSRTCGVGRQTRRRYCSKPTCEGYGEQGRACNSFDCEGTINPLAPGARRNFHPAQARWGPVSDRPHAFSLRPNSYIWIASSELFSAGKSFPREFTLFISLRLRPESGGYGQGTLFSLRSRRRTGSFLSLELAGRGAARLVHAGSGTSRSIYLAVPLYDFRWHHIAISVHDDNTVRAYVDCRWLRTDVLEKDALDTPRDADLIIGYLFSGDLEQLVLVPKAGQAQKQCSSQVVGISTPYVTTHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR42</accession>
    <name>A0A835GR42_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR42"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="94460" checksum="8851CB07DABA9486" modified="2021-09-29" version="1">MNEEEKTAIIQNLNLRVGNDINDLKSTLQIQAELTTKRDLLLKDLNAANDEVPQKLAAALEKAELNSSHIDKLKCKSEELKKKVEAFLNKTEPLRNEFDKRFAAINKLEEVLIYLKSFEKIDDLSKQMKQSNDDEQLVLLYSELKNMCIQYQKGHRASYVKEYTHYWHNVLKDKLTKNYEDVLKLLKWPFSAPPENPPAPKEVLVKFNSLTKYLFLIEEPEELVNNNVTNEAWQEKGPCLPVRVLLRPLKKRFQFHFTGSRQTARIDRPEWFLTQTLTWIKNHQGFVKHHVQPIADKLELKNVYAVDEFNAGLIALAAERLHTVLALYHTQSSKGEIADVDAAFAHAVDETLGFHRELVEITGKDINTVLSVLTKVETFLRWQTVEKKYALAKMDEILESPQWSEGVGSGAGAATGAALWIPRAADWFVTLLRTIEDRYKLLPQPGHRLNFLELQLELVEEWRIRLTQLLSAGLDSLHVDSFLSADATSHPVTAVINAAHHTMTVLLQWAHSLHYLQLHFYRRQFHNFTQQQHHDEEFSEETTDTDYTESDDTPVKKNKEISAQALSLMEVELQAKNLALSEVSRRNSLVVELNQYDITMPIANPAVAEPLTGEDEAEEAGVFAEAPALLARLRDSGLASLAEHILLEFKAGLKDYKRQKWHSLVVVEQLALCVSSSLCRPLAALCARLARAAHALAPPLTARLRAHLADIVDNYIFEEIVLESWFNTGGTMQFTYDVTRNLVPAFAPPNKVATEVYQLPRLLEACKILNLDYDDARRLRACLTKQSAAVEEHLDNHKIRFITPAQVLQILNQRTDLSDASSPSSVMELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR51</accession>
    <name>A0A835GR51_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase subunit gamma-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR51"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="38247" checksum="12AEE6CD8FCF506B" modified="2021-09-29" version="1">MKIEIEKLLQMKQFFTILQINDKKAKIILKKPSKLLMNNIHVNWLKYNYVKSDKHQMPVYLNSLSSKLAYVPLLYGVVKQDIHDYHKNMELEMDLDTGNLTKKSLLKLDIFIPREEAIQYLIQWQRYRKYWWSSISTTPSLFSVIDFKYENNTANVDIVAQFPNGHQTVETLSCETHPNHKYGQLSCSLCLENALLVLLLDGLNNNQKDEYLRLHRKIAPFKISLALKSDKEDIMDHDVFLLKMVTFLHHKLQMDKISTWLPNHSLPLDLQIKENRQMGVTYTAILEEETLKFGFLKLMSNSTKLMEQVHLKDFCKYASLTFRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR65</accession>
    <name>A0A835GR65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF255">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ALPHA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032335191" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="131"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="231"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="448" mass="50341" checksum="B249BB52E9D4BF9E" modified="2021-09-29" version="1">MQQPWWSIYLLAIFMLGLDSKLVGQAFQPEFAEPLMNLTVPIGRDATFRCLVQNLGGYRVGWVKADTKAIQAIHVHVITNNHRVGVSHNGQTVWNLHIRNVQEEDRGQYMCQINTDPMKSQMGFLEVVIPPDFIPEETSGDIMVPEGGTAKVSCRARGMPEPRVLWRREDGADIVIRDPNGTKTKVAMYDKEVLTLTKISRSDMGAYLCIASNGVPPSVSKRISIKVHFHPVIQVPNQLVGAPQGTDVTIECYVESSPKSINYWVRDSNEMVISSNKYEVVNTVISSFESRMALTVRRLTSADVGGYRCVAKNSLGEVDSVIRLYEIPGPTVKNTSPANKREEYRYSTPIEGPDNQFGSADTSDDEDERDIGTYTTDRHSNSYRNENVTRNRTINYAPTTEQKLNNKVRKIINKFEIEKFGNNRCCVHSLFVINCVLSLGIIVVLDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRB7</accession>
    <name>A0A835GRB7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase SIK2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRB7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="129463" checksum="5E6ABA2B00517A7C" modified="2021-09-29" version="1" fragment="single">QNQKYKEPRNVWITPDANEISQWDCRTKSETLKRGKRFKVMETKNMIYIVSEYASKGEIFVDMNMFVADYIARYGRMAEQAARRKFWQILSAVEYCHERRIVHRDLKAENLLLDANMNIKIADFGFSNYYATGELLATWCGSPPYAAPEVFEGKRYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPYFMSEDCESLIRKMLVLEPMKRYTIEQIKKHRWMAAEPYAVPTISADPARSPAHTQSHNEPNEQVLRLMQSLGIDPIKTKESLRSNSYDHHAAIYLLLLERLRARAASGASMSNVEARTRPSRRPSSVADQALAKEAHEARREHHTRLLHAGESQSREYNRATPTISSAPVDSSSAETQRLLSLAAVNMTEQRLLQRNSDPSETHRSFLVGNLDAISRSHESESTRLLSMRNIDVTQSNQRLGAKVNESSLPTHRLLTSTYEQQQNILKQSSEDCRRLLQQSTTVGSESSKNTIDGTRLLTSSSFDSKCAIDGGRSSSTTDHNAIANFLQNSASATNFSVDTMKLPNSTTFTMCSEAAKLMNTLQQSPLPLKGTVNLSTSPIPTQLGESKLSSVLEQPKPLESTRLVSQAQQQDLNRLQTSTPPFKDYMNHHLPAYAYLQNSVLPPMSSTTDANFSITSTATGDLFPSGLYRPDSKFSLNRYTTGQTYSQNLQGNSNTTEATKFQQQYSSSTDEGCETDMEDVANASGGVQNRLSSYASSSSSSGVVTFFNNKSLSQNLSCDSSQSNFSTFESLDYQLSDCSSELASSLPSCTSNEEKLAYDNNSLVNTSPMHPCVYISSYNNKTPGSVNNKNCPRAITRSPVDFREGRRASDGLVAQQAAQSNDSQKNSLAFNSQRLNENCKAKGVLELHLVQKEAQKLKTQYQSTIPAEEMTQRQIQHNQFAANFSPHYLDTKNPTPKRISLPETFNYSSTSPPMPASPKLVSQLQDQTELQHAASQVKPPLQQQLMQHRLFQQKRQLLQKQMTPPNVPAHEIGIHTLQVGLSRRQMLRQQSYKIAQQQQILPPLPLTETENRDLLAFQAIVEGPNRTPKQKPEEGQDEAKFAYQGSMEISILNKERLGNENWSNLPSSLQSAPIGKVTASHLQLVCYLSARALFWSSQNKWSPYNYSNIKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSD1</accession>
    <name>A0A835GSD1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032302572" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="496"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="715" mass="80504" checksum="4AAD29B2A6707F8F" modified="2021-09-29" version="1">MLSRTIIFVFLIKFSAAQINGEFWWLNDKLASIQGVRPPPPKFENLTEFDTDESAKIVFRDDNLIDGVVESSESISLSKDDIEKVNDKVGNNFIKWPEKDKFDQNDRQDQSTEKQTTTPDAEDKFVFKFPENDNFVWKDLMNTTFATTTISVLTTESPITNNNTIPYNDRLSFNTKYKEKQSEDICTFMKKTECNRSNGVVLDIKATDKLTTDLHKICCVLPLRDVDETNSKIIFPDAIKKLKRPRRSNKENFGLKQRQILLQRKYTSQSQQSRKPKPATQTKVASPDLDYDDPYWNVKNVKPPNKQKQIPDTRYDYITDDYIEDYAAELPKPGLTGLYSDHGQPPPEWAFVNKHKATSYGAGDDYENDDGGSFGYSTIDPRLGNTNKKSKPRVKPIKLTTASEESNYNVESQTISYQSNPNFNVLQDFKLLNLMRNKSHKPSSIARTTTTESFTDESSETTLDGSFSASPEANDDSDDQIFPDCGKISKTFNFKNKGKQIGEAVNGSHPWLGLIVSTRKQTVVQCYATLIHPRAAITAAECVYRSAPGDFLLIAGLWNLNAKAASRSRIISYHVHPQYKHDEIKNNLAILHWKRSFKLGPNIHPVCVDAPRLGDECIFVGWGGFDQAMRPKSRWQRASLHSCNGRLSLKGINIPNNALCASVQARGTVTGVGGSLICNKHGRQAAVAVAVSRDSTLVLLPIKDWLQRAIAVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU90</accession>
    <name>A0A835GU90_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9423995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU90"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032619640" evidence="2">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="24918" checksum="C22FA944C976956A" modified="2021-09-29" version="1">MLFPTILTLLITSYVVSEQQFEMKPHSNGKQKSVYKRNGVIERLKLYKTHVDNFVPELYKKQTYHVDEPHSRNRQRRSNFFGNRLTQQDCHFPKVKKPIPAQTYTVFNITDVFYGEEKMKNGVYTVWPTYTRKPFRLHFPDRESQEDFAESDAQENSSPSDYYLSSSGIKANETGENNQTASKSEIGLSINAFYSLSCSMVLLFSNKYYRENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUD6</accession>
    <name>A0A835GUD6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUD6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32046" checksum="D32C57F3CD817511" modified="2021-09-29" version="1">MNTDNRYPVTASLFMLKEIKHRQEQVNRGYQLLKRKAEALRMRGRQAASELASTQAILGHILREAYISLAAIKFTNGESNALVLENIGQAQIRVQRIPENISGVATVSLQALEEVGAWDSMCYAGLGAGGHRTSEAKKAFREAVRTLVKFASLRNTCILLDESIRSTLRKVNGIEKVIMPKLRNTETYILMEMDEREREEFHRLKMVKAKKVKNQARAVQLRQSASFGGAGETGEGDEAEPDLPPQCEPIECLTSILACSSLSTTTESGDFKPVCYPHNWDDDDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUN6</accession>
    <name>A0A835GUN6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUN6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="487" mass="53535" checksum="9BECB2F146E0F124" modified="2021-09-29" version="1">MVNKMYKISSAKEEKVGSKHNQILMSIVVCMPILAYGTAMGWISPNKALLMGDYSPASSPLTEEDVSWMASIMFIFAPIAVFVYGVAADKFGRKNALLCASIPISIGWAVKLMCTHPIALIGARALIGFGSGGGFVVCPLYVKEISEDSIRGMTGTFVIFSQTVGNLLVFILGDLLPFNTVLWILLAIPLIHFCILLRLPETPSFLVKCGRNEETAKVLAWLRSLPVDDKSISEEVDRLIIEQTTSELKFSPRLLFSDKTTVKAFWVALIVNLTREFCGCIAVLVYASHIFAEAGKDPSTSIALSPNKQSILLAAVQIIGSFLACQLVDRAGRKPLLAVTSAVAGFSMCLLGVWFYLQSIEVAMPGWVPIVALCVCIFADASGLQPLPFVIMTEMFNFQLRGTVATLIMAISLGTDFALLKLFAPLNVWIGYHSTFWMFSVICLSNVFYLIFCVPETKMRSLEDIYADLEGRKRRKKDDSVVETNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUX7</accession>
    <name>A0A835GUX7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="26479" checksum="220676157CFC462B" modified="2021-09-29" version="1">MVALTKSVSDLSKSLYARMTDFEKDLKKYPNTSSDTNQGITVEFSAFRLFAMQTLTMLQQQVNFLAQTIDTMEMRGRRKILLLHGVPETKEEDTTGVVVRVVKEHLKLDLEVPDIKRCHRMGRSTQKPRPILFKLHNTALPDGIWFGKTSLKGTGKTISEFLTKTRHNFSSVIYVLDGQGSWHQVSSLVDLDDIGVPSEASQLMQGRPEQRVKQPGVAAAAVAKVIAPKTKRVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXR8</accession>
    <name>A0A835KXR8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000486">
        <property type="protein sequence ID" value="KAF9407305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXR8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="13047" checksum="83EAD6981A29E237" modified="2021-09-29" version="1">MYSLPSATIILVVIPEDVPAGLAAIYGFAPPLHKGNDHRLGFGFRLGNHADFQILYEFGPQLVTKPLQTSRVRSTSYRQRFARRRPVFELLVRAGIIKRNYDYNVIKECDDEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYD8</accession>
    <name>A0A835KYD8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000585">
        <property type="protein sequence ID" value="KAF9406488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYD8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="101" mass="12166" checksum="92288860E242D9FC" modified="2021-09-29" version="1">MDIDMIDLMDLEDLDMLETSRRSNRRRYRRNPFESSEEDFRYKYRFTKRFGAKIVDILREDLCHDPRGCPLSPELQVVCALRNWARHEISSQLGNCLQNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYU1</accession>
    <name>A0A835KYU1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_008239</name>
        <name evidence="14" type="ORF">HW555_011473</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000344">
        <property type="protein sequence ID" value="KAF9409049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000461">
        <property type="protein sequence ID" value="KAH9636978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000001">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="133"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9409049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9636978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="325" mass="36761" checksum="403A7077D6CDA477" modified="2021-09-29" version="1">MQSVINTVKGTALGVAGYLTPVLKESKFQETGVLTPEEFVAAGDHLVHHCPTWQWAKGEEAKIRPYLPADKQFLITRNVPCYRRCKQIEYCEDKEKVIEDEHDADGGWVDTHHYDNAGSPTVEEKVCEMTLEAADTGDSDGEGAAGDRDDDDDEEDDEDGEAEDMEQFQESGLLDEVDPSTDLAQRKEPKAKPEKKSKSDGDEIVRTRTYDLHITYDKYYQTPRLWLIGYDEDRTLLSVEQMYEDVSQDHAKKTVTMESHPHLSGPSMASVHPCRHAEVMKKIIETVTESGGEMGVHSYLIVFLKFVQTVIPTIEYDFTQNFAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ27</accession>
    <name>A0A835KZ27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FGGY carbohydrate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000454">
        <property type="protein sequence ID" value="KAF9407606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000101">
        <property type="entry name" value="FGGY carbohydrate kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="312"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="583" mass="64079" checksum="DEAAFA2C963429CB" modified="2021-09-29" version="1" fragment="single">ILFGTLMAVAMIVIKKFKGQQGYLYFSHFQMSKEIYFIGVDVGSGSVRAALVDGNGHVLNSCVKEIQTWKPKVDYYEQSSKNIWECCVFVIKNVVANVNPASIKGIGFDATCSLVALDKHGNPLSVSTNNNEQNIIMWMDHRAQAEADLINKTNHDILKYVGGKVSLEMEMPKLLWLKKHLPNKWDDYGYFFDLPDFLTWRATGSLSRSLCSLVCKWNYECSIEGKQGWNRDFLREIGLEDLAADNFKKIGSKVLMPGELCGGLTDEVANSLGLEPGTPVATSIIDAHAGGLGMIGTHGEGIDKDMSSRLGLICGTSTCHMAVNKKAVLVQGVWGPYYSAMVPSMWLNEAGQSASGMLLDHIITSHPAGAELLKAMSPGDTRNHLRGLLIKMARLEGHSDVSYLTKDIHVWPDFHGNRSPLADPSMKGMICGLSMDNSEANLALLYLAYYASSIGDCSILFQYGTRHIVEALVLAGYEPFKSLLICGGITKDPLFVQTQADAMGLPILKPHEKDSVLVGSAILGACASKHFINVQDAIENMGGTADVIQPNLGTKVYHDKKYRVFLRMFQDQLKYKTIMTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZN0</accession>
    <name>A0A835KZN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000376">
        <property type="protein sequence ID" value="KAF9408561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006392">
        <property type="term" value="P:transcription elongation by mitochondrial RNA polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039150">
        <property type="entry name" value="TEFM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21053">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21053:SF2">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40406" checksum="D38E6709DBE61B2C" modified="2021-09-29" version="1">MLFKVVNSSRRILSPLCLSCRVSVVTKCYFSEGLDQKYNDVEKEKILQVINNPDDSILSGYEVSKANLKKVSQWKSSNGQMKSLSDIEYIDGFSEKTANKLFRSILSGPSKEKKANGKIKGQILHPYLSDSVLKECKSVLSVYITVNSVSWTLIDKSSYEVQEWKYYGIDYPEGKRFQITDILDIAWRVTQQLPHADIYVMKAAPTTLRAAGSDPNNPKVLAVNLQKAQMVAMIVALINSRNASLEPSNEESEDNVLKQKVYFLRPTLPYRLYGTLVGNERVSTDQTVEMLLQGFSEKSSNNSHAFVPKPLQDMFRSQKDLQKDMLGHCLLLSLTFMDLCIYNNKEKIEKLTRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZW9</accession>
    <name>A0A835KZW9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000255">
        <property type="protein sequence ID" value="KAF9410626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032620604" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="188"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="36430" checksum="16028A70ECF8B599" modified="2021-09-29" version="1">MLKSIYLMLLPVALGTLLPNDNNYPNPGFRKEIIGTQIYTFHRHAATFDEAQNICKQNGGRIAVITSRAQEPELVRMFKTSGPVINASHGWNRQAFIGIQYRGSGLWQTLDGKPAPYLNWSRNWMGVQPSNPDRQRCGSLLLQGAMDDVQCGVRLAFFCEKVEEKLIPFLGTFLPDDKSYPNPGPQNTETQVITFHRDAATFDEAQKICKQSGGRIAVITSSAQEAALVQIFKTSGPVINASYGWNLQAFIGIQYSQSGQWQTLDGKPAPYLNWSRNWMGVQPSNPTSQRCGSLLLQGAMDDVQCDVKLAFFCEKVQKKVQPCDCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZZ3</accession>
    <name>A0A835KZZ3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="405" mass="45856" checksum="957359ADCAE4B01D" modified="2021-09-29" version="1">MGYIPDFITLFWPAESISRRKCHSAYLIEITVSIFYSPWEIPNDHVVGDHCLSLTNMRVGALMPPCNKSSGRGPDGHPPTGRVNHAESWFARNSRTREEDINDSKYNKCSGPMKAGFSDGIRAYGYIIKGGNMVPDAAKVPSTASKVFYGNYGFRALAHYGHQSPPLNATTKVDVCCPRMDALLISLLLLIILKRRKRRRIQNHRRPIHRRHWVHPILTSRNKNGQHKLLFEELKCYPDKFFKYFRMSVNSFNELLSVLHDDLKHQDTRMRKSISPTERLAITLRYLATGCSFGDFELVYRCGASTARLIESDPWTSCTCIQYAAYNKTRPGRRDWGAARRGGKKPATVAVYAHESNDKTQPQVASALDSRSLWLGRGHSSAQCAPILYKMYEETRPQVVAATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L090</accession>
    <name>A0A835L090_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_011146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000313">
        <property type="protein sequence ID" value="KAF9409507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L090"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9409507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101662" checksum="B1D0183B20DDAAFC" modified="2021-09-29" version="1">MLMYGRYQRDLSEAAREEARRLRRLRKKRRKDDKLRQKELEASGKHRPRGKICMEAHVRSAGRGLGVPGSAGHHHGCRQLRHGPGIAVCQNARMWMYKDLATSTFSQYVAWVSLPVCLILFAAGFVHIVAAQSIGSGIPEMKTILRGVHLKEYLTYRAMISKIVGLTATLGSGLPLGKEGPSVHIASMVATLLSKLVTTFQGIYSNESRTSEMLAAACAVGVASCFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAACCSAIVNVPPPISMVWCDANSEAFFPTNLPQDFPFDPQEFAVFVLLGIVSGLLAALWVFLHRQYVLFIRNTKSLSNFLQKNRFIYPGFITLAVMSILFPPGIGKYMAADLGNQEQVLSLFSNFTWTDELTAEQASVVSHWQTLEVDHFGCLIIYFFSIFFLSLVSCTLPVPAGIFVPAFKMGASLGRFTGEVMHYFCPLGVAYGGHIQKILPGGYAVVGAAAFTGAVTHTVSTIVIVSEMTGQVTHLLPIMAAVLAANATASLLQPSCFDSIILIKKLPYLPDLLSSASRDFPLVDSPSSMVLLGSIHRWELVKVIEKQVGRDRRLQIAALWHREAELRRRDEEARKKVRRPSRFEVTPAPDMLQVPGTGMTRGSSLTTKDQGGLIPGQLFRPKSILKKTNSFTLSRGLGAGVPSAPNTPSTPQPSVYTTVTGAETRIRAAFEAIFKRSTLLQDVEGGLPDQLSPTSLPRSPSINKKVQLPRERVCDMSPEDQKAWEQMEMAKEIDFDRMLQIARKRDMHPDDPEYEDENLYICHIDPAPFQLVERTSLLKVHSLFSTLGVSRAYVTAIGRLIGVVSLKELRKAIEDVNSGALTLANRPEPPQTPIPTVIKVVSTQPAPPSDSETAKLTTPDGASCKRLVEIMKSDLIFSFVVLAMRGFRAILSVKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L096</accession>
    <name>A0A835L096_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L096"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="21132" checksum="B4C568B561500CE7" modified="2021-09-29" version="1" fragment="single">SEVLLSTSASFQRRTSAGDREAERPGERVSERRTERASERRAEPNTERPAGRGAEPSTERPVCRGAEPSTPKHISLDQFKQPSDLDVLSVKQLKELLVRNRVEYRGCLERKELLERAKTLWRNHAQYCDDVEALPAEECCKICMAAPLECVLLECGHIAACTACAKQLAECPICRQYVVRAVRFFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1X4</accession>
    <name>A0A835L1X4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000154">
        <property type="protein sequence ID" value="KAF9413585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="477" mass="54815" checksum="4F4526A5E37E0F78" modified="2021-09-29" version="1">MMVGCGTSRSPRMQIITEQIKNAKAQEKKIQARMKYLAEFNAKQRKERAMKARDKQNRIKQRVQAAAEMELRRKITMIRQWRANEKKRLNRLKQERESKLVRVETEANNKWIARVDAQNTKLQEEALLLQLYSEDMAAGARRRRKKSEIYAYNTDLELQRIRLANWKLMHGGTAKVARLVRKMGLEFEKSKRGAKGMSPELAQKMASEAMTNAMSTTGDTLMILGQARARMDMETVLPLAPIRILDEMLDSTIIEFARRRVHSLLLDLERVIRSQASVILFQNFKPTPTKKRNKPRWVQQIHSEMTRQFFHQRDSSMLGFGDITKIPFEDETTGELKSVKDRPPTPVPSKTKLAEVTFVDRIEDLPDPVPSFLPERKKLIEMANISARLLSKSVSQKVQKGLDITVGKVTLPPMRHPMEWGEAVEGLAMAVVDNRVNADCGDVRRTGDFLTHRILKALQNSMKFEKKSGSIPNLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2M0</accession>
    <name>A0A835L2M0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_000570</name>
        <name evidence="7" type="ORF">HW555_010409</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000258">
        <property type="protein sequence ID" value="KAF9410560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000278">
        <property type="protein sequence ID" value="KAH9640626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2M0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9640626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="400" mass="45253" checksum="F1F4BDC4B636D154" modified="2021-09-29" version="1">MATAALTGHFVTKIKPTTGPLSVVYIKSASYSSDGSKPNIAAYKRGTGGRCSFNGVVATVFGCTGFVGRYVCNKLGKNGTQMILPYRSDFYEAQRLKVAGDLGQVLFTPYDLRDEESIAKAVQYSNVVINLVGRDYETKNFKYKDVHVDGPRRLARISREMGVERFIHVSYLNASPKPKPLVLKKPSMYKISKYWGECAVREEFPTATIIRASDIYGSEDRFLRTFASPTRINGQYMALYKNGLETIKQPVYVSDVAQGIINAIRDPDTRCQVYQAVGPKRYLLADLVDWFFALMRKDEKYWGYQRYDMKYDPIIFPLKVNLVNLISPSYPLGGLHWEALEKESTTDVVDDSLPTLEDLGVTLTNMEDQVPWELKPFRAYQYYMAKVGEFPTPPNPKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2S6</accession>
    <name>A0A835L2S6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_008401</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000162">
        <property type="protein sequence ID" value="KAF9413360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2S6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032461311" description="Cytochrome p450" evidence="16">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9413360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21716" checksum="661D8170BB99D56E" modified="2021-09-29" version="1">MIPTSNQLTFILLLLGAHPEEQEKVYEELLEILGTDRDVEKDDINKLVYTNAVIMESLRLFPSVPSLFRTVETDVKLKNYTMPAGSYCVIFPMAATHLDPTWGPEPDKFRPERWLHGDFRNSKEYAPFGLGKRACIGRTYAMISMKVTLSHFLRHYRVKADMSHLKLNFDFLLKPISGHDISIESRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L348</accession>
    <name>A0A835L348_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General odorant-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_003545</name>
        <name evidence="5" type="ORF">HW555_008807</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000357">
        <property type="protein sequence ID" value="KAH9639014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L348"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006072">
        <property type="entry name" value="Odorant/phero-bd_Lep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015604">
        <property type="entry name" value="Odorant/phero_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00484">
        <property type="entry name" value="PBPGOBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032784051" description="General odorant-binding protein 2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9639014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19469" checksum="834FDE0EF67837FE" modified="2021-09-29" version="1">MCARVPAGHCDNMTSKCCLLLVAMATITAEVMGTAEVMSHVTAHFGKALEECREESGLSAEVLEEFQHFWREDFEVVHRELGCAIICMSNKFSLLQDDTRMHHVNMHDYVKGFPNGHVLSEKLVELIHNCEKQFDSMTDDCERVVKVAACFKVDAKAAGIAPEVAMIEAVMEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L373</accession>
    <name>A0A835L373_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000512">
        <property type="protein sequence ID" value="KAF9407050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L373"/>
    <dbReference type="OrthoDB" id="7428788at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032457677" evidence="3">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="222" mass="24420" checksum="0C41B5BC43870E97" modified="2021-09-29" version="1">MWNRAVFCCVFFVLVCAQTGDDDDKCLEIDCVGEGYECIDGICYCAKGYIPNHFQDKCMRCPGLGETCMGPCCNIYGNGTLSCWQGVCQPCYDDFGKWTCRESIEQILLISSTQVIMGAALILGIIATFILLYKLCATTDIRPFGSASNSEGRLSIGSLQLYVDERLRDAPPRYSRTPAAGSATYPAIAFLNAGFIHDSSIPPPPYTPENKTEDNRNTINHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L408</accession>
    <name>A0A835L408_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000183">
        <property type="protein sequence ID" value="KAF9412624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L408"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="21906" checksum="F81427A210331F17" modified="2021-09-29" version="1" fragment="single">CPQQPYIQRIVIENPSHSGIEYFNYRKRSQGRINDEVIFNNSVLWQSINRKEMNFPSPCPMTGSDIRRRIIKSYLGRKFNKILPRSRVIVEITFVIISSIFRIFRRTINLNLETVSKIITMACVLTTQLSTKKYLHPPGSFVVYDNRGTLVTPGSWRRPDNKYNTMQTIPSFPRRSPLNAQQIREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4D3</accession>
    <name>A0A835L4D3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_011756</name>
        <name evidence="18" type="ORF">HW555_005590</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000468">
        <property type="protein sequence ID" value="KAH9636920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4D3"/>
    <dbReference type="OrthoDB" id="9799930at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000173">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 15" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="14 15" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="16">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="17">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9417276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9636920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="13123" checksum="84EF80CE384B1831" modified="2021-09-29" version="1">MTSKVKKNKSRSSRAGLQFPVGRIHKILRNGNYAPRIGSGAPIYLAAALEYLAAEILELAAEAASDNKKGRVIPRHILFAIRNDEELSKMLSGVTISQGGVLPSINPILLPKKTMKNDNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4G7</accession>
    <name>A0A835L4G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_011586</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000356">
        <property type="protein sequence ID" value="KAF9408871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9408871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="144" mass="16638" checksum="07B9209C45089123" modified="2021-09-29" version="1">MAVTVTSLSLFVVAKNSINARRLENMRARERMRKSNEGEYPDLYRRLEESEMASPMLDPAKLQLVQELEIEMMSDMYNRLVTACHRKCIPVKYQETELCKGESVCLDRCVAKYLDVHERIGKKLSNMSQGEGEDLTKVNMDTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4U3</accession>
    <name>A0A835L4U3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4U3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="88" mass="10607" checksum="BF15EB1BF159E3AF" modified="2021-09-29" version="1">MAPKKKTSLSKEDLAKKKSEQAKKRLQKIHNDPVLLAEYREKERLKYLKKKEKGKRKCVKDMTPREHRVAKRKWVAYSADYRKKTKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L557</accession>
    <name>A0A835L557_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_005300</name>
        <name evidence="2" type="ORF">HW555_010911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000295">
        <property type="protein sequence ID" value="KAF9409833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000019">
        <property type="protein sequence ID" value="KAH9645651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L557"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032949884" evidence="1">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9645651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="21322" checksum="96DC740774CB9624" modified="2021-09-29" version="1">MNGNIIILIICVSIFYVACVRCERIKLLDPEVESLDKDNVGKLLGNHPNMVGQSNGAARRVDSTVHQTVNRYYCSLDSMIEGSHLMVYGSNGWTFPQQDVNLTLRYPPDDKETILHDDDEDYIITGFKVILFINGPTSEGYIMEGGVLQETITLSFISSRLTSLSYEFWLYGARKDTPGLTLNSHYRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Y3</accession>
    <name>A0A835L5Y3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5Y3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="28987" checksum="8B8E63A1799A8C10" modified="2021-09-29" version="1" fragment="single">ISAVTSKTTNKIKRPTSVSVPTSSRTKIVTKDTKNVPRTKKTNANMTTVDADATILKMEQQGLPDFDAEHRQIAYGKFLRAMLEECLVDEKIEREETVIDLQMSQLADRFQKTMDQLDKTSRRLKNISFVAEQKRLLDLKSQVNTQIFEATEKSNAEKLLEDLHTTEQRFLDKIELKNVDFGYNQVSGHKQLLDAVNDAIHGLEQIKKDSNLDLDKFKEYEKSQATIEELEKDRFDLEKLKSDFETKFPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L640</accession>
    <name>A0A835L640_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000079">
        <property type="protein sequence ID" value="KAF9417034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L640"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="135" mass="14803" checksum="1EF70655E7B9F564" modified="2021-09-29" version="1">MNFDESPGGSSSKGQENGDDSNGSDRPLKKARFAWQVKGKYHLKNDTNDAAAEATTSTESESTDEEMVAGCSGYTCLTPDDLLDNTDISEAIDPYLDTLGEYIYDQELKNLQYVTVTLVHTSTDSTIYQSIESTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6Y4</accession>
    <name>A0A835L6Y4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 216</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6Y4"/>
    <dbReference type="OrthoDB" id="262535at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16088" checksum="C54E6CC95A0B16F0" modified="2021-09-29" version="1">MSKVTNVNSSLAYEILLYLNSFYLGMFFVCEVAMGILKAINVSYPENALITEAGIFSALCLVEVIRIFLGRRGNLASKKVPVFFSVVLTIPSAVGVCYFLIYQTYILRLEYIWCAVMLMFHALELAFAILFIVTVCKHQQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7H0</accession>
    <name>A0A835L7H0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7H0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="263" mass="29321" checksum="112FECD5500488B4" modified="2021-09-29" version="1" fragment="single">ECIAVNINRIVVPALVELGTESVILDCDYNTGETPGPGLVIKWFFNGSTGLVYQWIPPLQPQVIGLLKGKVDMSFKISDKPLQAYRAIKIINPGTHLSGNYTCVVSTFIAEDSQTRSMLVYSPGKSFQFDQEKKYVFLVTLKCMAEYLYPRPVMTILSKGKPLERAITDMRMDSWGMYTVETTALVHDDDVTSPWEEFVCVLSLPLANYTSNRTTVYYPGLMPTHSASIEVKKPMEHQASNSSTLQLGCILLVTLLLSINFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7M5</accession>
    <name>A0A835L7M5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_015318</name>
        <name evidence="14" type="ORF">HW555_002881</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000934">
        <property type="protein sequence ID" value="KAH9627874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7M5"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00925">
        <property type="entry name" value="Cyt_c_Oxidase_VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9421169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9627874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="12050" checksum="4F81A0F7B8919ECA" modified="2021-09-29" version="1">MNTLLRKAAIEYLKTNARSSTHAATAGGHGGGFKLWKKMTFFVAFPAVGLGMLNAYLAHQEHAHAERPEFKPYDFLRIRSKRFPWGDGQKSLFHNPHVNALPSGYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7U3</accession>
    <name>A0A835L7U3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7U3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="10">
        <location>
            <begin position="357"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="681" mass="78720" checksum="08DDBC43249BCDBF" modified="2021-09-29" version="1">MENNIMEFTLPPAPRGLCFDRNDFVKTNFSVDNFLAEHQNVASLETMRDDLGVYLKVLRLAMIELINKDYANFVNLCATLIGFDKAIVKIQVPLGQLNDEVLSVKQCLEDAMKELSLWMSQRHGLQKKKQLLKHYSQTINCLKTLDKTRTGSSCHRAAMQYNQLKFSIAKCDSIIKPEHKLQYNEIGGKLTQTLNELLFYFWNNSEEENLLKILITLASLDRVKESEMLIRKQAVAPLLQDIINEPALQKSKEGLQGIYERILSLLDTKLKLLLTVTQHSKLSFLVKKYRFLVNCFWCEVENRLEVNLASIFAPGNPQIFYRRYSESVEFIKKLENYCSEEDMKLLHDSSEYKSFQRRWNLPVYFQIRFQEIAGSYESALQKSPTVEPNDAFVLRETQKCWNAIQECWSDGVYIEALAHKFWKLTLQLLSRYATWASAYCTQRIPSQKYEPTNVNKNLIDNSINIYVDIQSLLRKLPQLLELVKTKITIKNKDILGQSLNASETILQGTKEKIKDCVVNELYENFNVHLKQVSDIPRLYRKTNRSVPNKPCTYIDVVSNALKEFNEEASKKLDNAFTMELFESLFNIMTVSYYKYVEDVLTSVQKTEESLRRLKQIREMGSTQSSDSAGVTDGDKIRLQLNVDVVSYGNLARTLRLNVNSVHKFPELSSMVTDAVKNIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L886</accession>
    <name>A0A835L886_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L886"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="695" mass="79652" checksum="D8E192828CC22982" modified="2021-09-29" version="1">MGAWRRAEGPPLMDVRRRYSRRCNFNETSVKLYGRGCRPKKCSNLLNSPFFCLLFYGLELQRTYIKACLIHGINTNENNITEVKAVNSTEKTVSNKTIVPADVERFSDQDLVKILVNNSQSLERTDIDKHEIKVSENNTRRKSRDILNSSLISGIQCYTCHGKDSSKESSDCFSGNSIPLKKCGDAEQCFVELNPLYIKRGCVLPGRVNRTFICKCPLCNDKPSFDISHYEYKKLNDWEFDNARLQTPVTGMELMCKVCDTKGMNPSSDKNCRFGKKDNKCEKRSSVRFLFLFTITIHSNCSEVKQSKKRLPYFRRKVEELGDRDFFKTTESDDPRNLVSFLVKNVKEIFDDIIDIDNNSGKSTKGHVIKKKIIRDKKRNRSTQSRRFTTTTVNFESMYIDTFTTQQALICNSSASISTSTPADDEMLDENLPLTTLLDKQEISENDVLSLKDEHLQLSNAIKEYPGPDKRERDIVGLVSAQQFRVNSSVPESEVGDLRRSIPSVMCEHDDDVCYSLHTPFGIVDRGCYNVNHNMSTYVCSCNLCNYISISEMPLMFSKKRDWVDNVIELSRTRHLRKSVFKDMSCLRCEVNTTTKTGDMLDSANCLEGNIGNLPVEDCRVGEICAVKVLKADGYIWRGCVEAPLYNYWWAVCDRDLCNYDPPVFLHDFLMNDLLQCQNYKVHSSRFPTKESYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8X8</accession>
    <name>A0A835L8X8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001453</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8X8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000751">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF46">
        <property type="entry name" value="METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="504"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9423149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119767" checksum="868B18EF67B64A2F" modified="2021-09-29" version="1" fragment="single">LPKAKSNRIVSILGLFELSVGDAPRADGVSELAAARLAVDHVNKRGLLPGYKLHLITNDTKCDPGVGVDRFFHALYTERDSRMVMLLGTACSEVTESIAKIVPYWNIVQVSFGSTSPALSDRTEFPLFCRTVAPDSSHNPARIAFIRQFGWDTVTAFSQNEEIYSLAVNELVTQLEAANITCAASITFAESDFKEQLQQLKELDTRIIIGSFSQEMIPKIFCEAFRLGMFGAEYAWLVSGMPPRIRGAPPCARPQLARALEGLVTVTAHRGIVGDAASISGLTNEMFHREMEAAGVAVSPYAPQTYDAVWAIALALSKAEQLWRSLGDQNNNGTNATRLGLSHFDYDRQDMAKEFLDQLANLSFVGVSGPVSFNGADRIGTSAFYQIQGGRPKTVALYTHGREMTCSECTRPQWAGGVPAARRVLVLRVDSVWPPARLAVAALAALGVALALAFLVFNLHYSKRRSIKLSSPRLNNMTLIGCVLVYTAVALLGVDNATLPSYVPFSAMCTGRVYILSAGFSLAFGSMFAKTYRVHRIFISNRSGVCKTKLLQDTPLISLVCALLVIDGMIVTLWTMLDPMERHLKNLTTEISTTDRSVIYQPQIEVCKSQNTTGWLCALYAYKGLLLIVGVYMAWETRNVKISALNDSKYIGISVYSVVITSASVVVIGTIISERATLAYISITSLILITTTSTLCLLFLPKIVAIRSNAEEDPVIQSMGLRLECKTRRFVTDETQELHFRIEIQNRVYKREVAALDKEIGRLEKLLAEPLDSGSGSNASLSLHKRTELNTVEEEGLAHVDGDRRTPSISGGLPMLLLSVLPPVIPRASWPSTDAFRGRNSVSFSSQPKLNYRKSQPSIDLYNLCLNKREEHTGLLSRIKSFFGSSRPSSRKASTMSIADPTGASIAAALKMHVGMIAGLVPGNRKHSMVLSCNTLHVPHPELKLRRESYAKSGPIIRVTDDEPSCSYEPDHPRPLQQKYIAEPETKVNFVLPTTHQRPMSHQNSCEKIKGSPRFPHRIAPSAANSLTTLDTRRKTSADSVFNITARVFEEQRRYSHQNVSRDAKGKSVLESRWKSTEDARPGPSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9A0</accession>
    <name>A0A835L9A0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="465"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1638" mass="186128" checksum="C7138C2755869BA3" modified="2021-09-29" version="1">MYLPENKKGSGETKKPIRNRFQRHTSILIWKCYLQRQRRAGLLLVEAVFSIALFFIAILISKPVFLTPLQDEPEPPLASGDILASLHTNNILGYAPNNQPFVSIMHRAGILLGLEIMSAQTEDDLNEMLYNRSSGAPLRSPENNIWTLSIRSTERARFVTSSENRETSNPHLRAGFLAVQLAISQAIIEHSSIEIPDFEVTLVSMPVSPLMEEGAVRQALSAILLCFTLALIPPVLETEALVVNETVNSFKRALRLRNVGYATMYVSWLVYAYLTCLPICVLASITLILIFRWIHLFAALLVVMAYASVMIMLALMMGMFHSKASIACVWTTLFTLMQTYLAELLVHHEYDLKHSALTFVLHLILPPIGLVHALNKFALLQTGHESISPETSSLVYMVMSWCIMNIFYFGVLMMLQRTIGQKRAIGGQVSWSSIIFKKVEDRNQLHTIEAPTRSERGKVQQVDELVAKAISFRDSIMGVPVLSDITFDIYRGEFTVLFAERIQDTMLNTMEDLLTGLTFADHGTITVLGERLEHGTVVMTSPHMMGYCHHSETLIEDLTVQEHFTLFSMICLWNRMKLSIFEYAHVRTKRLLKECDLEKVKNERVRNLNIYYKAQLCWAIAMLLEPRVIVIPALTDHRTYVSVIKDKIMQYKKYKTIVSLNFSSMQIEYADRIFVFDSKILVFGGTPAYMFFKYGREYRVRMTMKSGISDDTIKELLNRAEQAGATVRAHLGSLLILRLPASPTATVAELVKDLTDNSNKYGLTSFNISVADSEEVCRRAIMDSRLHVAEFEGHTSKRSKRALSKIMEPVKWTRQKSFYNIHLGSIGYKFFAFHIFHKLLFAITLLAAITAGAALGFSLSSVLFHMDPGRGSKKVISGEMQVLSVESLEIYTTLVLRADNSSASQSIAHGYVLSDTKATQNEIENIEYTSLPHTESLTEYLVTRAIDSPQVYVYMYAYGMDVSTDANGTVNWLKDVTTPPLFIQFMLILTISHITLLPSKEYGLIRHIQKHAINFSPTRYWLTLYFFDLILYWMLVGVMSVIMITIMLLTIPMTYLNYVDLFIVPFMLTVYGIGCVPQAYIFSLGPRMALNTMTFVIVNLVFGETTILAKIFYGDVFSYAVDFMSLSPQFNMAYAFVKIKQIFLYNSECVIFKARNLCPMNTFHKCCEKCGVLQDCFSTKSYFTRYPGVMMEVIATCTTAVFFTIILLLIEYRIFYRLWNYGTAKLGNRDKPAFIPLTPGSQREQNDVIEKKQQIKKHKHNEKVDTFGDYILASNVAKRIGNFYAVHNLFLGIGRGEALALSGLKAHGRTTLGEILAGYTTPDVGNVWAMSKYKLRTQPHKYSQQVSVSCDRDLLPSWMGVSSALELIAALRGVPRKFIKGEVKNYIKALELEKLANQYVEDIHANDRTRIHFAAAVIGAPPTIVLDECTAYQDHSVRRAMYSILNALRKRGHAIFISSSSIESHMPVTNKLAIMLDGHIYDVDSVDNMVERYSKKGYTVVVHLKDEVDVTQMFSRYFVNFVINDTTEVLVNIQVLDTELTWAGIFEKMEALKADNQEVYSYIVTVIPIDYIYNTIINKSSGNYRATGLCSWKWFKKLMSVKPEIVPKKRALKKLIPFEQKYDITKLTELPWSVIFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB44</accession>
    <name>A0A835LB44_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="271" mass="30479" checksum="1EFBED4AF3A4A6EF" modified="2021-09-29" version="1" fragment="single">MNDCCNLFCLSTFNFGTCPNTAKFAGDVEIFDFSLFLPAGALKGHCNREEDLLQRCSMALPVLSSPEISFALTREELDKSCVELRMGIKCIDNYTNVCMEKHEQVVFRRIYAGITDVVQELCTRGPYQDEYLKHADCVKTVRSDYETCSKNYEVTLMTLGSHQQGDQYQTDQAGLVTSHEDHLRTVCCSFQEYLMCSEQTVQRSCGDEAALFTSAFLKRMASNIIKNFCFEYNRQECGLPDKGSNISHSVLLLSVASLTHLAFYASGNLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBE6</accession>
    <name>A0A835LBE6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="26107" checksum="09507F3F522F3834" modified="2021-09-29" version="1">MEKLRFTFAVLAASDGKTNVICITSIETPDGCVYDVPDEQKNANKHTSIISLEVYAKIKNSLKKRHQTRKIWIPLTDQILKIYLDAGENVQFNDLYLEEITEDIKSSNNNYKSESEHKNFVKIADKTLVTSTARLCNEIGKQEYTVTKKNFTKFTKNVPDNTSKYQKEIACKICEKLNKGIRYHPEEKCWFKPTNEYENRNKYFKNVNNTLLCIELNDNEQKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFZ8</accession>
    <name>A0A835LFZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nibrin second BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10980:FF:000001">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nibrin second BRCT" evidence="2">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="520" mass="58400" checksum="9C92C285E2A8641F" modified="2021-09-29" version="1">MNGILKGDWDDTCNYLTMPAITLTIKVVLALVQGSDIVTVDFWNKCLENITNFMVLPDPKEYLPKIVESTLNKEVVSFLPDSRRRTLFKGKKFVFFSKRQHEMYKTVLFKSGATPMLLSECRMTTSMLCAENMIVIQYIASGASQETQSQKKTINDIVAQLKNKGKRVVADAEIGLAILYCSLDKYCNPNFSFTSEVVKQTQAPVKQSKVLAPESQDPDSEQKKENIVIDESLMSEEQANNHSNKRKFSEVTTEGQVNANKKLATSCLVANVKTESVKRRLSDDDKSLNPTKKVAMDKENNSETLQNNPPETADNDSNDVFNFVKTGSTNNTMGNKVKKLNLARPQKRKINDNNADENLFNFVQTAVQNSQDVKSDTNNTPKQNFSIFNINKKKNDTQDAVEGNIIVPKIKGLSADEISAMRGSKLKELMEQNSRTLPTLKKEKCEELEEQMNKLDLCCTIVTSCNNLIVKRESIIETDISSVQNTSLKNFKKFKKVWPIRRSTCSINASSINLSDNTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K1DDT3</accession>
    <name>A0A0K1DDT3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemosensory protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CSP12</name>
        <name evidence="4" type="ORF">HF086_008905</name>
        <name evidence="3" type="ORF">HW555_000202</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>Putative chemosensory protein genes from Spodoptera exigua.</title>
            <authorList>
                <person name="Liu N.-Y."/>
                <person name="Dong S.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KP729030">
        <property type="protein sequence ID" value="AKT26488.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000188">
        <property type="protein sequence ID" value="KAH9642495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K1DDT3"/>
    <dbReference type="OrthoDB" id="6344725at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035992531" evidence="1">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKT26488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9642495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14307" checksum="9E467D6E57C275D0" modified="2015-11-11" version="1">MKLVIILALVAIALARPDDGFYDKKYDNFNADELIENDRLLKSYAHCFLEDGKCTPEGNDFKKWIPEATTTSCGKCTDKQKVLVAKTIKAIKEKLPAEYEALVKKHDPEHKHHDDLNKFLEKYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2A5</accession>
    <name>A0A835G2A5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ciliary microtubule inner protein 2A-C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_014024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000815">
        <property type="protein sequence ID" value="KAF9405087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2A5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146:SF17">
        <property type="entry name" value="PROTEIN FAM166B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="6">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="6">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="247" mass="29062" checksum="EFF4D57B08223BBB" modified="2021-09-29" version="1">MKLSGKLREGSAVIIIELPRYTGHCPMLKFRFGKCYGDNTRQILREIRSKGLFNKPLEYRPRDNYELNHLPRFEEPQRDIYDGIRNKPPAHMTGYTGYVPGMNFSYGKSYGRTADDCMANFTERQRELRRKADLNRSYVRSRSAPKMETVHSRDEIRRDLNRFREINKYKENTISPEFPPIAGYTGHIPRIKGSEASLSQRYHCAAKRGLELIKMERENRKELQNADTNIKAILKENGKKYSYWNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2B5</accession>
    <name>A0A835G2B5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000711">
        <property type="protein sequence ID" value="KAF9405605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2B5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000003">
        <property type="entry name" value="zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000006">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="270"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="471" mass="51961" checksum="F648B1BE95F9D476" modified="2021-09-29" version="1">MSSEAPQPVFRSFGGEPDEEPEVTEIESLCMNCHENGMTRLLLTRIPYYKNVVVMSFSCEHCGYQNNELQPGGSVAERGVRWALRVEGADDLNRQVVKSDYTSVRIPSLDFEIPAQSQKGEVTTVEGIISRAVAGLTQDQEARRLHHPEDARAIDEYVARLDRLRQPDAEPWTLELEDISEPVRPAPRPARLLTHFKRTHDQDHQLGIYTNTEKAEDTECPRIEGLSLSEGAEGAEGSGRTSKEHLLSPLGADAMPYERLAADEVLSFPTNCPNCDAPCYTLMKVTNIPHFKEVVIMSTTCDYCGHRTNEVKSGGGIEEKGVRFEVRVATKEDFSRDILKSETCSMEIPELELSVGGGALGGRFTTAEGILSAMRGQLEDSPGALGDAPGLAQPALQDFLATLDQVLRAERPVTIVLDDPAGNSYVQSLADDPNVPDDGLKITRYERTFEQNEELGLNDINTENYRPPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2R0</accession>
    <name>A0A835G2R0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000897">
        <property type="protein sequence ID" value="KAF9404735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2R0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="302" mass="34159" checksum="821F0274FDC912B4" modified="2021-09-29" version="1">MLPETVARLQLPAHLIYTDGSKSVDGVGAAYSYWRDGTEIRTKRMRLESMCTVFQAELLAIARATDLVVRGGFGCAAVLSDSRSSLDLIRNSETHHPLATHIRKNIRELEGRGKILQFFWVKAHVGIPGNERADELARLAAAQSRVAPAYDRCPVSYVKRRIREGAVHRWNERYTGGATAEVTRMFFPDVSRAYRVLGYLDRTSIWAQTLTGHGGFAAYLHKFKLKDSAACVCDPEVPETIQHLLLECPRHDRDRYDLEVSTGIKLNEITVAELMANKDSRPYLKRYCLKIAKIAIDRNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G365</accession>
    <name>A0A835G365_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000893">
        <property type="protein sequence ID" value="KAF9404753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G365"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9859" checksum="DF89A30CBACC54C1" modified="2021-09-29" version="1">MGYFEAPGVLSPRHLAGDWSRFVDVNALLIFDYLPSCPDEWLQIEKDFALKFPRAVGSIDGKHIVLECSINSGSEYTLTVKAELVSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3A3</accession>
    <name>A0A835G3A3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hflx-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000864">
        <property type="protein sequence ID" value="KAF9404868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3A3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11060:FF:000001">
        <property type="entry name" value="GTPase HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="197"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="354" mass="39867" checksum="C87CD7173E1DC7C8" modified="2021-09-29" version="1">MDKIVEKVILVGVETEENYLRFEGSMRELKNLTKTAQGEVVFSLTQKRPRVDRQTLVGKGKLEELVQLVNAYEADIVIFNHELTPRQNQLIAEAIGVKVIDRVQLILDIFAMRARSKEGKLQVELAQLNYLLPRLVGQGKQLSRLGGGIGTRGPGETKLESDRRHIRDKITAIKRELKQVTAHRERSRQKRQASDVFQIGLIGYTNAGKSTILNVLTTAGTYSEDQLFATLDPLTKKWQLPQGMIVTLTDTVGFIQDLPTQLIEAFQSTLEESRGMDLLLHVVDASAEDRLQHEQTVVELLNDLDLEQIPVVTVYNKSDQVDEDEFIPTLFPNVLISAKSTSGKERLTKAVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3B2</accession>
    <name>A0A835G3B2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000755">
        <property type="protein sequence ID" value="KAF9405353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3B2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="227" mass="24298" checksum="77D38252A38BE62B" modified="2021-09-29" version="1">MLLMRPRLNLSPARVPRPLLGLPVGVYLRAAGALNLYPKLKDFDQQQTNVTLVSLVRPSIPGLDGFTGRVAAADAGRPCGSGALSKLGLIGYIGGWTEALILRVDESDRLAVALILMVWVSGITSAFVDNVPLTTMMVRVVTSLGTHPTLNLPIEPLIWALSFGVCLGGNGTLIGASSNVVCVGLAEQHGYKITFMQFFKIGFPVMIGHLVVATAYLLVCHCDFSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3P0</accession>
    <name>A0A835G3P0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000439">
        <property type="protein sequence ID" value="KAF9407758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3P0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="147"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="462" mass="49848" checksum="915AA1ACCEA7A0A9" modified="2021-09-29" version="1">MGTVHAKAQQGGDSVGEVGGGLFEFEEPLEMEDERVAKPTIKLNGVRARVDRVHVDGLNRTKDDIIRSTVDDLFHATDFEDVRRALDEMGCFRDIGVFIDVSSGPGATPEGLEVTFQVRELSRVVGGINTTVSENEGNLVLGVKMPNVLGRGERLAAEYSMGYRSSSNFSVAATKPFPHKPLVPVLAATVYQQNHEYPWSGYRLLDRGALLDLAFKTSPATRHNVQWEGMVRDTAVLSKTTSFKVRESSGPQMKSILRHIVCVDHRDEPMFPTRGTWMQFTSELAGLGGGVAHLRTELLAQANHSLRPELVLQASAALGVLHDVFGTELADHFFLGGPTSLRGFRQRGVGPHCDGQATGGRVYWAAGLHLYAPLPFQGSRTGLASLFRSHLFANAGCLAMPEGAGLAALEALREARVSVGAGLCVRLGRGARLELNYALPLRAGPGDVRAPGLQFGVGANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3P1</accession>
    <name>A0A835G3P1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_014355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000998">
        <property type="protein sequence ID" value="KAF9404391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3P1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9404391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="11658" checksum="AB5158DACF791212" modified="2021-09-29" version="1">MAAAMPINPKPFLNSLTGKSVLVKLKWGHEYKGLLVSADGYMNLQLANTEEIVDGSCTGNLGEVLIRCNNVLYLLTLEYDGPPHGGLRKTMSAFSWDANSKKSPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3W3</accession>
    <name>A0A835G3W3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger DNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3W3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27557" checksum="CE81F47F65FDEA02" modified="2021-09-29" version="1">MCPGCKAKQPRADNSQTPVKGIEICPSPPADAGIQVVERSMAEQKEVCVLETANTPSSSATCIEETVEVSLATEIRCLRGEVSALRHEVREFRAELMGRVDALEERIAIVENKYEQSVSPRITELETTVGDLKLQLNERDQETLLNDVQVSGVTETKGENPSQLLSILAVKLGVQLDDRDVVFVRRVGNVLRNRTEEEGATAAYPRIIVARFTRRVTRDSILSAARVRRNLCTQDIQVPGESRRIYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G468</accession>
    <name>A0A835G468_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-binding protein D-ETS-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000550">
        <property type="protein sequence ID" value="KAF9406771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G468"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000996">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF182">
        <property type="entry name" value="SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="262"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="410"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55322" checksum="76B25908FC72D0E8" modified="2021-09-29" version="1">MRSLINMILNLVFSCSQMPQTVPRSGCSPPSASQGERAVPASPADLQHLLRLLGAASPPEPMLHSPPNPHNKPPPPYPEDNTNNVFLERLYDFEGYPTPSPSSDEGSIPAVTLQPSSPYNSLQYSPQVYIKEEPNRLAVPGFASPYPLSPSGSCVSYGSHNQYSSPVPQHEEYIDIEELLKENQILQESVQQSYITPKIEVEEPRDHILLRSALEDTSFQKRLNLRPIPLELGSVKMEDSSGGDDSLVAPDIDRVLSMAIEQTKRDVDNTCTVLGISPDPMQWSTGDVKAWVMFTLQHYNLPMVPMENFTMDGAALVTLTEEEFNHRAPQAGSTLYAQLEIWRTSQGSDHQQLSASPIPTPAGLPSADDMSDGLAKNQELATDKIDEDSESAGTSATVGGGKAKTGSTHIHLWQFLKELLASPHVHGSAIRWLDRSNGVFKIEDSVRVARLWGKRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQFCHPYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Z1</accession>
    <name>A0A835G4Z1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000545">
        <property type="protein sequence ID" value="KAF9406827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Z1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032528533" evidence="1">
        <location>
            <begin position="16"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="46203" checksum="3C5A5CCF3F957B6C" modified="2021-09-29" version="1">MLLLLFLTIIGTVYTENCSYIYNGMPYDRTAVLTIKGLPTNLVINPVNDDLHFTLIDLDSLQNDKVQTKMDQYVFSKGQPIKIDNVNGQAAAVDMKNKKTYIASDDGLYYLDESNKAQFLSLKDDDIVQLFKPPSDDKLYAVFFPENEVFVIDVKKNEKKKVDNVPCAFILAVDAQENIYYECDSKYVKVILKGFQEPIEFVGIAKNSARAIAVDSYNRVVLATNDGLYWIRPDNIIPNKFMDLDFVPSGLAFDYEDIYVAASGVIYKYNANGYTINGCHEPAFTMRSLTIILSVFTIFIAGYNTEKCERIKIGNEFYKRQLIATIDGYPTGMVIDPRTDHIFFILHKRNYTKGIHLLKHGSLGIKELPVSDELLGQCVAIDTANNVIYIGTNQGLVTYDYSRTENYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G504</accession>
    <name>A0A835G504_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000499">
        <property type="protein sequence ID" value="KAF9407183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G504"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="96" mass="10106" checksum="51D8D67CC913142F" modified="2021-09-29" version="1">MQGMAVLRAVRPIDKATAVGTSIAIVALLSFILGHLIYLFISHMTCVYSSNGACLLHASTIWIAGGTSTLLAALSAAGCFISSKMQPYMDEPTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G513</accession>
    <name>A0A835G513_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000467">
        <property type="protein sequence ID" value="KAF9407468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G513"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032595134" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="17564" checksum="06C5C9A67AC1400D" modified="2021-09-29" version="1">MTKVLFAIVLMMTTFAVTLSASTKEAMATTMTDQVNSIEVDVLAVMDMCNDSYRIDPTYLQALNESGSFIDETDKTPKCFIRCVFENVGIVSEDGMQLNPARAAVIFAGERNGKPMEDIADMTALCATDRQETCPCDRSYKFLRCLMSMEIERYEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5B0</accession>
    <name>A0A835G5B0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_011410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000335">
        <property type="protein sequence ID" value="KAF9409131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5B0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9409131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="367" mass="41610" checksum="4FB9ACFC3D695437" modified="2021-09-29" version="1" fragment="single">VWIFGDVWCSVWLAVDVWMCTASILNLCAISLDRYVAVTRPPEEADIKDGWVPNPPCEWTCELTNDAGYVVYSALGSFYIPMFVMLFFYWRIYKAAVRTTKAINQGFRTTKGKGMGSRFDDNRLTLRIHRGRGSNRPHGSPLHSSARRAHEKVKISVSYPSSEQICPAHENSMSSSRSPSPSLYAVHYERDGRELTESRLRVRPSHHLAPGPLYDEYDDKPRTTRRMGKRNIKAQVKRFRMETKAAKTLGIIVGGFVFCWLPFFSVYVVRAFCGDCVSPIVFSVLFWLGYCNSAINPLIYALFSKDFRFAFKRIICKCFCGGGGPRRESDGEGSRRQNNKPTHSHSLEEHDANNHTSTTTSTSAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5T9</accession>
    <name>A0A835G5T9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000399">
        <property type="protein sequence ID" value="KAF9408200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5T9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="205" mass="23052" checksum="51BE22DD0E12B07D" modified="2021-09-29" version="1">MEKVFITNILAEDNISSQIFLPPSDELVYNVHIPRRLVNKPIDEPAGGAAVPPIQTGFNNKTENGLNTTKTKGEKGDMEAQNSEAVISYPPYGSYQVTENVIDIPDNRTKAGPIDPYYTIRPELNIANATGAATTTEANKVKQKKNRVSIHIDAEYEREEIKENKIVGFLKGVKACFQNFQKGIIDGFYRFFHRNEDVLADREKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5Z5</accession>
    <name>A0A835G5Z5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000448">
        <property type="protein sequence ID" value="KAF9407660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5Z5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="54143" checksum="B4C0ABD07D78F694" modified="2021-09-29" version="1">MVPRPAPQFPTPPLIPEYFAGREVLITGATGFMGKVFDVVRERCPQQLDKLCMVPGDVTKRRFGFDQSALNQLNQVSVVFHSAATLKFDEPLSVAAEQNVRPVLTLMDICDQLPNMQVLVHVSTAYSNAELAEVEERVYPAPVTPEHLLALVDALPASMLQEITPRLIAPKPNTYTFTKAVAESAVSERAVTARYACAIFRPTIVVSSLRHPFPGWIENLNGPSGVVAGAGKGLLRVLRCGAQRRADMMPVDICIDTLIAVAWETGIDNLREARVYQCASSSHAATWGQFRERMLRLVREHPFDNVLWYPYGVICENTVVQKVLEAVLQTAPLCVAHCVARACGLKQKPSLWTACKRLQAMNQALQFFATRHWSFRTTRVQQLAHRLHPDDQKLYNLRPETIDWEQHCVDFVKGARRYLLRERDDDIHAAKRRMRILYLIHKATLLFAIFTMCRLTIRTAPAILWGVAALTRQRNKSALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6F6</accession>
    <name>A0A835G6F6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6F6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032301740" description="Spaetzle domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="2">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="185" mass="20852" checksum="820ECE5BEC9BF652" modified="2021-09-29" version="1">METFGLILLVVQISLMITSNATPWGVNSAIDVPEECKGQGFCTVRPPGYDKIEEELNHILPKQMIDFHARSSQPTNFRPEDDDDNCPTIVTSKSVYLYDNNDEEPDIIVQTKFIPQIVTQVNCAWSRMENGQECFKNLGLSPFGMKSSCREHSATRSLLVYDTRVKKVAIKNYTIPVCCSCHVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6S3</accession>
    <name>A0A835G6S3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000356">
        <property type="protein sequence ID" value="KAF9408865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6S3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="31322" checksum="813B2DC35115FA1B" modified="2021-09-29" version="1">MSPRQFWYEFLQLYRSFPCLWDTSDPAYVRRHERKQAYDVLLAKVQEVDETANIYMVKKKIDSFRTSFRREEKKVIQSMQTGDDIYIPTLWYYKELEEFLGSTSIDDHRNSTMSVTSYENDNDNDDESQCTQLKYSPPSPTPTKKRKIPQPIIIKRKETEHSRIFAQPLSASQTEEEDDCATFATNLKVQMRSINTEQKYIAQKLISDVMFLARTNRLTYNSSINSNLTYKTLTFPAKSGTSVTVTPDLPMRQDNSNAHPIKIKAYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G881</accession>
    <name>A0A835G881_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000311">
        <property type="protein sequence ID" value="KAF9409537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G881"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="653" mass="72528" checksum="0182B0742C3D2243" modified="2021-09-29" version="1" fragment="single">MAGVVKIRFDEEAPSPTPTTPASIKRASTQNSQRSLPEIPHPVGRPDSGDTASEIYATVNLDEGKTVATASTSRDHPYEHAYAKVQNESHNILVEVTTDQTPEREIQIDEREVGQNPAESVISASVAISGQLPSSQELPYITPPSPRPNTDNNTHFSGDSTDSANEMYAAIEEPSVGEGSDTYAQISTEPRRRDPTPDLLHTDPTHVARRSAPPDVGASTSNATHSRQGDLFNHDKLRRSLNEKHQRNNSCVSSSDFYGCNYPVEKHRFSSGDLIRPLVARELNFDIDQRDSQTDNLYNSIDGPGYSDYSSADANTSLNSDHRVTESPSRNVEEMYAKVMKKTKGRTEETVRRSKDFTGADSEPHTSKFRGDDPGYETIDRKKSINHGYETIAHKERKSSQNQDPGYETVKDINKAGPTSNFTNNNLLKLNHLAVDSGPNSIVSSDAGYEHISKTDNNASDSDPNYEVLRNQPPTPPYATITPNYKVQPTYSTVNKKPNKYNNWPANNNEEPTLEPNYESMPHDPLYNTGSESDPNYESVRPKDPNYESVSTQDPNYESLRCKDPKYESVRSKDSKYDSVRSKKDPNYESVKYFELSKKEPPYEKVNNDASGSASVERSDSAAGYEKISVPNRSEPKSSINNGGDATVSDYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8E7</accession>
    <name>A0A835G8E7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000374">
        <property type="protein sequence ID" value="KAF9408586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8E7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF6">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="69"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="219"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="360"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="510"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="647"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="874" mass="96452" checksum="6882DE38497EFF15" modified="2021-09-29" version="1" fragment="single">MIYDAACDWAACDTVPSPEYEGQPGLEGPGRDSPSLLTPVPAWVLAGETTELSSRASLAEPTPTKLPKCDRTFVSRGGASNGTFHAPELINPNNQSRQCLYTFLAAPGQRVLVEFRTFDLRGKPPDGAAVGELPACMHESMDIYSEMASLEAGELVNSAFGGRYCGPIPPRRRVSLHRAVALSFYTDKMYTPPTLFTGTYQFINASEFEVGTPVPNTLCSFVIEASKRKTGLLLSPTYPGIYPKDMTCNYLFSGQPGQRIRLEFRDFDLFFGGPHCPFDWVRVYDGPDNTSAVIGTYCGQQRNLVLYSSDERLLVTFYTLPRAASTQNRGFKGIFEFSESFVKLDFISKHDAEHIRGSECDQKILSKKESTGFVYHPNYPFPYIQKVVCRYFIYGMQDSQNLERVRLEFQNFSIPKGENPKPDSCPDGYLKVYLRGQEATDSYDKHDAELCGEGSAGSPPFPPPLLSDGPRLVMVFSSGELQGRGFKAKYTFETGKISSAGYSGAGRRVCVHVSKRSEEARRVQLPRYPSNYPSHTNCTYTLAASPSEQVTVVFDHFKVRADAWNATAGVYSGATCSEDWVEAWWVGREGARVPLGRWCGLATPGPMHSPRGATGLVIALHTDSEAVASGFKARYIFEPAKSIFGDCGGNMSGAEWGVITSPNFPQNYEQPKNGPASRVCNWFVTARPGKRLLLNFEYFAVEGHLTERGCPAAVLRLWYESPGPPLELCGEKAPGDRWQYLSSSNSIRLSFIIADKAVGATGWRAVWTEVTVPESGSARRARWTAAARACRPPRAAPASSTARSRPTPSPPTVSMHRFYCRTDSAATDRQSVGPWAGLTARCAQAARRRGGWRRAPLWSRCRLCSPPRTDRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8E9</accession>
    <name>A0A835G8E9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_009715</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000222">
        <property type="protein sequence ID" value="KAF9411523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8E9"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052943">
        <property type="entry name" value="TMTC_O-mannosyl-trnsfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44809:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="19">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="587"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9411523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="681" mass="77342" checksum="1359529FDE2F0DB7" modified="2021-09-29" version="1" fragment="single">LNHALAGLRPWWWHACNVALHAACCALVARACVTIARLQRPFAALAALLFAVHPVHTEAASEQQEVCVAQRRARSSQYAGQETGIMIFILNLAFDFYRCWPFVKRSICSLKIEKKCTGLSLRTIKVVVSLALLVCLRLALLQGTWPSFSPQDNPAAFHPSFFVRLMTFCYLAAFNWWLLLCPWTLSHDWQMGSVPLITSGWDPRNLLTCAAFGALLVLCYRFIADLEVQKHTPAVIGVLLMVLPFVPASNLLVTVGFVIAERVLYIPSVGSVIITAYGVQLMWCSKPGTKVYLAIGLAVLAASGVARTHRRNAEWRDRATLLRADLVTLPQNAKLHYNLANFLRETEQQDSAIKHYKEALRLWPSYASAHNNIGTLVSGMENAEHHFLQAIKFNKYHVNAHYNLGKLYKKSGRMQQAVTMLEKCIWLQPRFVQAHVELLSLKTENEKQRILRRLVDLEPSNWEHYVLYGDWLRSRGLPAPAAKYYLEATRLSFRYRGAERNVRADLITFRYTALMYRSLGQKSRTLQLLTRWHTWRRGWPSAAAAHMYLRDWRLKMELEGRAQLYSKAVSPTKSTKCFDHTQLAVGSKEERIPQNEEKNKTVDTKSAIKTSSDKKDSDNRSCGTKKRNLSVSSQIKTTHNKSEIGLKDKKCTLHRKDKKKGNGVIANIGAPLAEHILMKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8X5</accession>
    <name>A0A835G8X5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_010849</name>
        <name evidence="10" type="ORF">HW555_011684</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000365">
        <property type="protein sequence ID" value="KAF9408719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000612">
        <property type="protein sequence ID" value="KAH9634369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8X5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13751">
        <property type="entry name" value="TGF_beta_GDF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000006">
        <property type="entry name" value="growth/differentiation factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF262">
        <property type="entry name" value="LD29161P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="158"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9634369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="270" mass="30767" checksum="EBB07BAF5B2F900F" modified="2021-09-29" version="1">MQALNTRRHNHFKGLKVINFRFTNKVLQNELDEAVLNLHIQELESKNTTIDPDEPFTINLQVSRVTRNNQGSKASVPYTDNSVKMTRSELRSGKWLKVNITTMVAEFCQLPRENLAIVVRVQDSKNRMSLVVPHPSSESNNALMPYIEVSLKDNSHKRTRRTIGMDCTENSKEARCCRYPLVVNFEEFGWDWIIAPKVYDANYCSGECPYSFLQKYPHTHLVHLAAPQGSGGPCCAPRRMSSITMLYFDHDYNIIYGTIPGMVVESCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G982</accession>
    <name>A0A835G982_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000351">
        <property type="protein sequence ID" value="KAF9408958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G982"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="983" mass="114840" checksum="E348B1D40A990377" modified="2021-09-29" version="1">MRMVHESIYSKMDPEGTLVSKLNELLDAVRRGNIDNVKNIVNWFEQDLNRNKALLPAVYAGARPCPTQADLIVAACSHNQKSILDYLLNETDILDHLIDNTQELELELKKRTNAVKHALRLGDFEMVEKMYNYWSGDLYWNGHEKDKFTNLGKILKDAEADCDVVLVMVSDQQLLINFKSLNTLNDFQQELYELLPQTLPHNASAKETAEVLLEVLCLYNKYSKIGRVRIPDVSDEIERQLKLDLEDETSTYYRAQAYIKYEVYFRKLDFNIAILLLEKLYIIRNHLKQRFNNSKTYFEENKKLFEQYKSAATTYKDIECAIFHLIYRTSEDWRLYLPADRKLTVEKHHVGIYNGVLIRNLKSTYDLHKLYNGPVLYFERDHFKTCIGKLKNILNDYFLTDDPITNQVNKENKEELLDENYLKPMMYVSDYYSLRKIVMYIEALEHTNDADIIMIERVLQVIGEMMKASEGSKHLSELTSTFLQTAISAETIKLLQQIREFLSHADKGQLSLRIDIENDRPDILRNVKEELVKIKEHIFPIFDICKSVLDKSLLQKGLDLLESRIKKMPVGARKRLDEISSLYKKHGINLVSISGQYFRDIWDPAGLPHQLLLEIPQLLVNRDDILAKKETIEKEIDDKVMKMLPQNIQNMKQLLKLMQKNNDIVNDINSQLSKYKIKKLEYCPKAIDINDRKRKLEKKLKNKINFPEDFSQSWKSIQIMISYCPKHTNMFSSTDTSTISGLSSLLEKMEVVCLMYNSRIAWFCGKQLAKWGLWIYKTFREMITRSETTSFIAIENLHKDTVLKVAQKSSGKGRDELIKCLINRIDLLRTALGHPEQIPLREHVQRYKLDLEFRFMLEMLLTDIDNIINNKKYVSRKCNKLLEGIILRNVLDHGNPFLEVIGDVLDRHELPEELLSKAKSFAEDLEAVKALYALYQDNIDLATIKNGTLANMNETQKDLHSKLKQSQNWERYLCLIPSSHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9J3</accession>
    <name>A0A835G9J3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Staphylococcal nuclease domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_006887</name>
        <name evidence="9" type="ORF">HW555_010611</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000448">
        <property type="protein sequence ID" value="KAH9637243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9J3"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20433">
        <property type="entry name" value="Tudor_TDRD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000018">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000002">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000003">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047386">
        <property type="entry name" value="Tudor_TDRD11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="325"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="508"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="715"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9637243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="894" mass="100080" checksum="486B98157F8D05F0" modified="2021-09-29" version="1">MSAPAPAPAYKIGIVKQVLSGDTIVIRRQPQGGPPPEKVIALSGITAPKLARQKTPNNDTESKDEPFAWEAREYLRKLVGREVIFTADKPPNSATREYGCVWTGKDPIKDDNVIEVLLTEGLAKVRDGGRNIPQLKRLVELEDVAKSQGKGIWGPDLQDHVRDIKTWTDSPKALVSKYNGAPVKAIIEYVRDGSTVRLCLLPDFYQITLMLSGIRCPAVRQDGESEPYAEEARFFLESKLLQRDVEVILESVNNNNYVGTILHPQGNIAEALLRQGFARCVDWSLAVMKSGASSLRNAEKAAKEARIRIWTNYVSNAPIIAAKDKEFTATVMEVVNGDALVVKMPNNTQKKIFLASIRPPREKNNPDEEGKNSPRPKGFKPLYDIPWMYEAREFLRKKVIGKRVNVTVDYIQPAKDNFPEKSCCTVIAGGVNLAEALVSKGYATVVRYRNDNDQRSSHYDKLLEAELKAQKAGIGVHAKKDIPTHRIQDTSGDSAKSKKFFPFLKRAQKTEATVEFVASGSRMRIYIPKESVLVTFLLAGINCPRGSRPAIGGGGMQSAEPFGEEALQFTKEKCLQRDVVVTIEEMDKAGNFIGWLWNDNENLSVALVEHGLATMHHTAETSEFARQIKTAEENAMKKRIGLWKDYVEVEKETEKERNAPTQDRTVKYEKVVVTEVTEEGNFYAQNVDLGSKLENLMERIHQEFKNNAPLPGSYVPRRGQVCAARYTLDENWYRAKVERITEDKMVHIFYIDYGNREIVPSARLAPLPPGTEVEPAYASEFTLCCVKFPADPDDRSEAVAAFSSDTLNRKLLLNVETRGSPPCVTLVDPNTNVDIGKNLIKEGLVLMEPLRDHRLMALVAEYRAAQEHAKCSRLNLWRHGDITDDDAVEFGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAI8</accession>
    <name>A0A835GAI8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000259">
        <property type="protein sequence ID" value="KAF9410518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="92" mass="10189" checksum="920518FCB51EB401" modified="2021-09-29" version="1" fragment="single">DSCEPASPKPLRQGSSMELEGSDEDVIPQRFQLGKLLSRDEMDPTTIKSGATSKPVQKQSHVTMRESFDKSSLEVNKASLRFSETKGKVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB02</accession>
    <name>A0A835GB02_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB02"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="178" mass="20629" checksum="7A4BA75EA307E5F0" modified="2021-09-29" version="1">MFTVSCYVFHPLLHRFVRLWRYVQVVSDVLNFYLTMLCCPCANEVPFSTSSSVDSKPSVQIFKAEALAKAQKQVDHERSCGEPVKAPHLVIDFTPGREDTPEIQERCQQYWQDAKNRQEHNDMTSTSQSPIDLTTDGSHHDRRRESQNNIPRVHMHKKHSKKGNVQMPLLEHSNIMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBH0</accession>
    <name>A0A835GBH0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000231">
        <property type="protein sequence ID" value="KAF9411245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBH0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11423">
        <property type="entry name" value="bHLH_TS_musculin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF72">
        <property type="entry name" value="HLH54F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="25188" checksum="7D1A8593973EA9C9" modified="2021-09-29" version="1">MPRKRVNRSPPVEKRSDDADDDDFFFDDNQSNSGRSSQEPQHRNAANARERARMRVLSKAFCRLKTTLPWVPADTKLSKLDTLRLAASYIAHLRALLHEPRSAHTPPHPLSLAWPFAFQHGGTLSCAISQRWNINPPNNDSSSRNAQPPRENTQDSHTHCDGYPDYPDNDYEERCYEEMNTNESCAANMQYCNYGYKDNYYEMRNDMRNSYASDSMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBP1</accession>
    <name>A0A835GBP1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000151">
        <property type="protein sequence ID" value="KAF9413764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBP1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000096">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF104">
        <property type="entry name" value="MATERNAL GENE REQUIRED FOR MEIOSIS, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="630" mass="71906" checksum="FD8E2B72227E3608" modified="2021-09-29" version="1">MGSEHYCLRWNNHQSNLLGVFSQLLHDESLVDVTLACSEGASIRAHKVVLSACSSYFRSLFVDHPSRHPIVILKDVGLEELRTLVDFMYKGEVNVQYCQLPALLKTAESLQVKGLAEMTTLSAAGIETRKVQEPMEECQPQETRESSESHEKADGRDHREKEERRELKDSREVRERENKETRDVRETHARESHSRDSRESRESREHRDREQREPRDLRESRDIRETRDPRDLRDPRELREHRESRESRDISRDLREVRDPRDLRESRETRDHREMPEASPPRISPLLSVRRFRSDITGETPTLSHPPIPKDEPPDEPMRSSSPEDDTVSIRSNGAQNENIGLNMTINSHSSSSVLGAHYSPVEQRLSVLNTISHPGLTHPSHASLPSPRSEPIAGPSGLPPVQQVPLSLKKEIDWDRSNEDKVGGETSSEYRMQHESEYDGSGRGRIDEGERGYPCIHCGAAFPHQSKLTRHILTTHTLDTLKYRDALLGRPLGLPMIGQFSDPTYMSMHAEESPIELDIGAVEPGNVVLCKFCGKSFPDVSSLITHLPVHTGDRPFKCEFCGKAFKLRHHMKDHCRVHTGERPFRCGLCGKTFSRSTILKAHEKTHYPKYARKFLSPSPVDTEEESPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC50</accession>
    <name>A0A835GC50_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000142">
        <property type="protein sequence ID" value="KAF9414118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC50"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="10756" checksum="FDE12B794F3010E3" modified="2021-09-29" version="1">MLGKCMRADIYSQLVQSELVIFTYIKCQCMASMKKIFYVVDIKLRNACGSIEETHCECAVGSGHEAHCKHVLVALYGIAHMVNFHNYKHSIAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCE2</accession>
    <name>A0A835GCE2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000198">
        <property type="protein sequence ID" value="KAF9412183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="35589" checksum="B7E051FA8CD48539" modified="2021-09-29" version="1">MITNEVTNYDNRREVKEDSSPEQRRANFVVDEINFVRENNELEGTNTTEMNTVNETATIENVTCNYQNSSTEEEDVETSYLANYPFSVSIQKRGAHYVSGALIGKRFILSVAGEFYHVRDSLKLFRARLGSVDCKRGGTLVPIKKIEIHPYYVYGKPNFDVALLRLASPVEYSDSLRPIGISKINGKVLSAKFMTTYWPRIVLKGKTIPETAKERIKHNRMRVSTQKLIPVDKCNKIMKAINEHINESSLCLEPIVTHHSECMPDAGAPVVAEDGLWGITSGWVAPTCPTFAAPTIFTRISSISVRSWLDIQLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCY3</accession>
    <name>A0A835GCY3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000166">
        <property type="protein sequence ID" value="KAF9413254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="31176" checksum="6BD551FC5352D5A3" modified="2021-09-29" version="1">MVWSFDIINASRVVKNSSISHHFFNDQRSSPWKINVATEHKEDGEVVPVQRVSPYKELNNFINLVKSSAHISEMQRLDLQERFNKFDSLHSQFDELQTEIELLADDAETAFVEREEFDRQFFNLVALTRSLLGSSVNGAGSEAGFKDADSVQLKLTYSVALKTCLPIHYYTLNLFAQKWDSFVCVTDHIDKRNTEGVTSESPANLDDLTKCNENFCEPIVVPMFCRPIRGEARLSKSPSTSLSFNEVSRWMTSALKINQRFFKDLILETRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDK7</accession>
    <name>A0A835GDK7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1504" mass="174981" checksum="D66107B62EC86168" modified="2021-09-29" version="1">MTEEPKDPNAYDPKVRWVNPQRLNQMTFIGKDVFAVAHDIYIILFNYKTNTETVYVANNQKRGDGVDVLAGHRSYMFAFAEKVRYARIFIISYPSLTVVAEIKDPEVIRYKGICMMESDLIAAFSGFPQYLVTVWCWRTNQRLLSISAEVQKRNQMFVASRTHMLICQCWSEGVNVWEVARCYKKCFMLKRQFVAAADWDTADQPMVAGICWSLEGQLYAIDGKANLFGLSSDGIALVKTLEWSEKIKGNRQTSICSFLNGLLIYGPDQNLRFLRKDVEGKSWKVEWQYVPIDKVVRLVSNAFCDMATMWTNSGFVYKITADAEDKIEVTLFTIKQRNIKKIQLIAPDFKYLAMMNDNAILSIYEVNEQKLILMKEIKALDVSFEASPADPLLAIFGEVNGNYGVVLQTFEPETGLKKQSSMCLTYQIVSRVAFSQCGRYLVAAAMSAGHIFIFKVSTDYNLNLVRYTELGRGLADCFLMKVGEAMRCFSLVLFSEKYSIGERVICVNAETGKDNKFAGKMQGPYSRLLPLSTKDTIIAIPHLSKHMHILKISGEKGLTVSVKMGPIIESGHDIKQFDGFRGANALVTFGYDGVVILRPPHASEEYENYLDVQEDKKVHEEAMDYKRQRDEVVKVFTSLQKKLVDLLEENINERPLHQLSLSEFNLHQEAKKERLRAAEKEREEIRLQTEARIRAQDKVTAWIKQKCWDTIQVPRIKIFAIFSHYHVESYPMLPSQRDTWAELQQIEALRTIEKENDANMFRPWLEQSLVETPSKQAEVPAPSMTVDSITSFRDTLRSVEGGEDDVAVDVVAEPYVLSGTNAHRFVSIPPFMIPQMEAFSFLQMNWLYHIFTTQNMRKWFNKQFEELMQTKKREVALVTERNARLRFIIEELNKLSDLRGSFHHLIIEIHDPQWRQEEHVEKLIKVEPEECSIEPYISPSQIVIVPPDPGPKDDFRERALMDMMDGVLEKLWHEEIKKPIPMPQCMLEKDPENFNEDDLRLVFDYEAKVKFRNEERDKYRKMLHAEYAKLSQVLNEGIVKFNQKVRDTWLTKIKVDSVIGQENLNLMRLRRINLDRIVMSEVIEEIRDEIALYERELEKLNSEFQEIQEQSQDCQAAYEALTAKDRQMDKTFKNHFADLSPIIVDQAYKFFKRRPKWHQRVTMIPVVLYELAFAVATGTKPPLLHPDCFDFFKGMEQLDQISNMPTVMDEHIWNSMCKLRRAKTENEIRMRALIQEMTFVDSAINVWSKAIHARRSQLVTCQGKVSLHRETVELEARNKTVQLVLPAGQVEIMTTGHMEDFEDATLIPKEDVEKINNLILLRMMRKQMDFRKGILSKEWEHAQMKMKLRHMKQELYSYQRLKIPKELQLYLKNKELGYTDEQDYIKMEKENEASKVAVNKILNEQIHRSGEIEVKLVNIQKAVEKIEKLITHLNVKVSEKKLNEDALEPIKIRRVFKKRMETLVMRSRLIREVQANHSTIVMLQTELELLRLKTYPTLASFRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE09</accession>
    <name>A0A835GE09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30750" checksum="A9D0C74153AECA64" modified="2021-09-29" version="1">MCDRITARAQPPNGLVHRSRPVRSYSMPERACRSLSRSRRRRYNSVPPVRAARSECCIAFLAEGKPWSADDFTQETAQKSAAWSSDYYSSDNSATYHRTNSGSEASYQWSGSPKESLSTPMSPTHGGENAVDQTLASLASGWSLFTSSVSKAARTATESAVRYGGIASQKVTEMASTVTERVNNRAGWSTLGGSTDQRRGSQTSGSYQSSGYGAMKTSASEPYSSWNEQLQPWKESVAARNNLDTRDLSQVGVSSPPPDIKNLTIKKKNTSDEDSWDWLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE68</accession>
    <name>A0A835GE68_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000179">
        <property type="protein sequence ID" value="KAF9412738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE68"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26408" checksum="1C0E635A224CD93D" modified="2021-09-29" version="1">MVVGFKRVWDSSCPRIWDQWVDDNGTTWIIQDLPPEDDEKAIKILVENLCPDETLCSLSKIVEDPVSTQSISDFWRGYLAQRMSLACYELKDGNKKLVALNVCLVQTKDEETDDVVEGEGFKNVYNALKVVDDKVDAFKYLGMSQILYALGLVVCREYRGAKLGARILAARKPLSLYHGIKGTSTVFTGPASQISATRAGFTTIGTITLKELAENGLNFPNDENRNIKVMVKRFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFJ4</accession>
    <name>A0A835GFJ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFJ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="24267" checksum="BF1F0FBA28D6DFFA" modified="2021-09-29" version="1" fragment="single">EVIQLLVTNTNLYIDKIKARFGRDRDALPSDDTEMNAFLGLLIMAGVLRASHLNFIDLWAQDGSGVEMFRLTMSYKRFLFLLRCLRFDNTSDREERLKIDNMAAIRSKELLTPEYKLTLLAAALVTDHQKRRIQLRAVPTTTKKRLREVHDVDETVQQSTAKRGRCSSCSRKNDKKLTSKCFKCHKFICQQHSRVYCVGCRTEESADETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG04</accession>
    <name>A0A835GG04_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">A-kinase anchor protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG04"/>
    <dbReference type="OrthoDB" id="2148342at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053084">
        <property type="entry name" value="AKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025663">
        <property type="entry name" value="AKAP_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14469">
        <property type="entry name" value="AKAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21382" checksum="1437B8DB37C60B36" modified="2021-09-29" version="1">MNIPEIKSYQEQAIDTVVSVINRAKEKLGVRQTLRQLANSREFACNAKLSLKAIGPPFAITCEKFILKTIEKKWKLADKFMYVVRYMGESKNEVSQYYYFEAIFSQPTASYPIPQATVSVFFILEDKHTEPTNERGVPMMFFRVEGHHTEHDIRFVALSADWILAMLKMKIKLFQRIETIRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGD1</accession>
    <name>A0A835GGD1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="412"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="561"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="708"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="854"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1298"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1551" mass="177004" checksum="6D736C4C29CF75BC" modified="2021-09-29" version="1">MKSKMKAHTMTEDIVFWKWISLNTLALVTKMSVYHWSMEGDSTPVKMFDRHASLADCQIINYRTDPKQQWLLLVGISAQQNRVVGAMQLYSVERKCSQPIEGHAASFATFKAEGNAEPSTLFCFAVRTAQGGKLHIIEVGQTPAGNQPFLKKAVDVFFPAEAQNDFPVAMQVSPKYDVIYLITKYGYIHMYDIETGTCIYMNRISSDTIFVTAPHEATGGIIGVNRKGQVLSVTVEEDSIVPYINTVLQNPELALRLAVRNNLAGAEELFVRKFNMLFTNGQYGEAAKVAAMAPRGILRTPQTIQRFQQVPTQPGQTSPLLQYFGILLDQAQLNKFESLELCRPVDPTLALSVYLRANVASKVIQCFAETGQFQKIVLYAKKVGYTPDYIYLLRSVMRTNPEQGAGFAGMLVAEDPPLADINQIVDVFMEQNMVQQCTAFLLDALKNNRPEEGPLQTRLLEMNLMSAPQVADAILGNAMFTHYDRAHVAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHLLPADWLVTYFGSLSVEDSLECLKAMLQANIRQNLQICVQIATKYHEQLTTKSLIELFESFKTYEGLFYFLGSIVNFSQDPEVHFKYIQAACKTGQIKEVERICRESNCYNAERVKNFLKEAKLPDQLPLIIVCDRFDFVHDLVLYLYRNSLQKYIEIYVQKVNPSRLPVVVGGLLDVDCAEDIIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLETRVHEGSNEPATHNALAKIYIDSNNNPERFLKENQWYDSRVVGRYCEKRDPHLACVAYERGQCDRELIAVCNDNSLFKTQARYLVRRRDPDLWLEVLAESNPYKRQLIDQVVQTALSETQDPEDISVTVKAFMTADLPNELIELLEKIVLDNSVFSDHRNLQNLLILTAIKADRSRVMEYINRLDNYDAPDIANIAINNELYEEAFAIFKKFDVNTSAIQVLIEQVKDLERAYEFAERCNEPGVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYMDVVATATNRESWEDLVRYLQMARKKARESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGDRCFDDKMYNAAKLLYNNVSNFARLAITLVHLKEFQGAVDSARKANSTRTWKEVCFACVDAGEFRLAQMCGLHIVVHADELEDLINYYQDRGHFDELISLLEAALGLERAHMGMFTELAILYSKYKPAKMREHLELFWSRVNIPKVLRAAEQAHLWSELVFLYDKYEEYDNAALTMMQHPTEAWREGHFKDIITKVANMELYYKAIQFYLDYKPLLLNDLLLVLAPRMDHTRAVTFFTKAGHLQLVKAYLRSVQSLNNKAVNEALNSLLIDEEDYQGLRTSIDAFDNFDTIALAQQLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDALYADAMEYASESRSAEVAEELLNWFLERDNYECFSACLYQCYDLLKPDVVIELAWRHNIMDFAMPFLIQTVRELTTKVEKLEEADAKRSTESAEHEAKPAMIMEPQLMLTAGPSMPYAGVAAQASPYAYAAQAPSPAPYHGYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHL0</accession>
    <name>A0A835GHL0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHL0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032296819" evidence="1">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="209" mass="23474" checksum="7B6D2AF355B5E9E0" modified="2021-09-29" version="1">MVTKLTLLLLLIQLHQALNLPLRQLRELKPGAEIPMLMPQHNAPLTVPQVVIHTATREKKSPNIISIPIQQILVPKFHIIPLHHAHSNVHHSAVHTDVKHIITHDNVKIPIISQTVSHSTANITHPTSASVIPILIPLHHNLVPVQDLSVIPLQKTVHKEQKLERYTVMEKKEEKENEEVNRFRTFYGGYGTGLFFGGQGAGHGFHIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHS0</accession>
    <name>A0A835GHS0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHS0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18501">
        <property type="entry name" value="BACK_ANKFY1_Rank5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049763">
        <property type="entry name" value="ANKFY1_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="20819" checksum="029765B970AE16A8" modified="2021-09-29" version="1" fragment="single">MTVATLYGRETYSDITIKLQSKSMPGHKFVLNARSDDWNEEALRNLEELDWTTLPDEIGAALLKWLYTDVVDLSRGDSFALQLMKSAAGFKLHGLVGKCEQALIATVGVRSCVKFYSAADEIGASALKEHCSGLISAHWDDLTGEDFAHMSSALLYRMLKSKTSQPLHGAVRLLREDVVFLCLVENHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI77</accession>
    <name>A0A835GI77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_004301</name>
        <name evidence="3" type="ORF">HW555_006275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000104">
        <property type="protein sequence ID" value="KAH9644040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI77"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9644040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14173" checksum="F5FF3E47A712D3C6" modified="2021-09-29" version="1">MAAASSTAAAQQAAEEDDDDVTFNVEDVQKIVRDNIELCLGGNTYSHSRCAQWISNITDKTLTRLNKLNKPFKYIMRITITQKNGAGIHTAASYYWDIATDGSCTVRWENKYMYCIVNIWGLALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI97</accession>
    <name>A0A835GI97_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000017">
        <property type="entry name" value="Adenylate cyclase type 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="5">
        <location>
            <begin position="113"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="5">
        <location>
            <begin position="439"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1662"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1798" mass="203954" checksum="B64A54E6983E788A" modified="2021-09-29" version="1">MNFLKNKPRARRNSASIMVSTERWRHYSRKMSRRGQELFDYDADDYEPAQHNKENKNWVEELFERKSDAEEIEQDIEIRLTKKQTLFLSTLVPDEILLMDKFNTVDAKRFVGVLLMADVSGYTALSERYNNTGKGGTYRLTATLNTYLGSLIELIYGHGGDIIKFAGDAFLALWKTDKRSFLCHTIHTVIACALIIQHSYAIYETDVKVNLKVKLAISAGNIIFTPIGKGIDMSYVVFGLPVIEAKAAESVCASGEVKLTPTAWGHCYSRNYDHIIHENGYVTIKSILYDPHESNVTKPFAGFGNIIRQSKKPFSAIESLPDFILDSSQRTNITDALRKTEALSLRKTILLAEEKNIGSEIRKFMIRPVLTQIDAHQPLEYLTEMRQVSILFVTLKPRECSFSQLITIVNNSYQITCEIVYKSMGCVNKIILFDKDIMILVVFGLRGFKHESEAQAALKCAYSIKKSVAALDGVLEVSIGVTTGQVYCGVVGHPLRREFTVIGAIVNKAARLMCGFRNKITCDEMTFVKSKMSTNSFTLQPTIELKGIVKPGKIYEYSEEIRVKELYDIPMIAPLLNRSDELEYFEAWLGDSKSNFRDFDALLIIGESRIGKSRMLEWMARISRNLGFQVCYLSLTSIHSASAYLALSQIINQILELKEPVEGFAKEEKIIQLLKVYSDDLCYLNNIIKVRFAYHERIHSLDETKRKEKAKAMFEKLLKALPEITVIFLDDLQNLDALSWEFISMMFKSMKIFIVLSVTRGKFSAVHNWLYSVFINNNIRKMALGPLDPEWIPALACQILDVDGVSKDLCVALQSKCKGRPGLVESFIIHLFSSGALEIKRIERTEIEEWGDEELQFPEPALLHPQALDGNDQDTLDKLIENDAKEDIGICIVTNKEELNSNINANNLDTLIMIQIDSLTPYQQLLLKIASVIGDVIPRNLLENIMYENNALITAKAIKRLFCLKILSCANTDCLNKFGRKTSTLTIISAPSACNQNIVCDCCFEYDAENDQNLPKYAFCKLMRFRSKNSRKTCYELLPMNQKKEFHTRIVNYLEYNKQKCTSCGGTVMVVQSMLSLMDEASNSRYSSVDIVSNKLEQSLELQDSEDSESSSISLTSNNLVRAKSETVTTTKVYSTSIRSSETLAQTTSLDNAVRSKGSDSLAAPILKVKSSTVQHPSTENQKRAKKVTMTYLSDPVLNTNSGEFKNHKIFDMLREVTEADAPSDWQNLGIVDSQDDLDKIEKGKGCNTFSVKIEKGISQTNFAKCTCAELNIIICEQIVYHAERADLKSKAVEFLIKCSHLCVLSNNFENLFEKLDNAENLCHSLYNIDPYQKRRFFGQIHTIRAAVYLSMGKFAAAKIEIEQATEIYNIHLQKVPEYFKLKNITNAFKFRNRKHRLNKSLLKADSVYCLNIATVLYSILGDERVARTTALRALNIVQTLECSVVNVCETYCNAIQVEIDRGTPETTAEIEQMAANSLKALSNPIQADELFAVGKLFMATFRARIARGELGPTIRSGFRALTVSRFLQAEDISLELIPDLFYILLTRRRIEEAIDILQFALRTGQDHMTYESENWYHALCIDLILDAGFQLESPQDISRFAEYSICRGKSAGPSRRRLVVGLWTYWLRADSDRRAKRFENEALSWASHEEDSSLVNLFSALRLAEGMLESLARKVNDLRKVVDLMELRSVADRELARLENDARLLRAAFPRWCLLKANSSMLSGRNVTANTLYNQALDEAIKINNRLDEGMVRAARSNSLLWIQNARTGQFVHWREGVTIARSSWHHIMYRMSTTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GII3</accession>
    <name>A0A835GII3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GII3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF4">
        <property type="entry name" value="DUSKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="194"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9416590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="593" mass="64709" checksum="645C72A2CFF0F277" modified="2021-09-29" version="1">MGRCRGKSKSWLSQSVVERPTATTHIQVEILLTSVADRRQLRLSPYSDQSSNESGGGGGGAGADTSSAAEPSSDQLAMESSERDTPSHAYNGPPPPAPPPHNRRQNPPHHQAHHPLGMPRIPNHHQIHSKPFALGPPVNHHKNDVGPGFRGPPPPPAPPADAQTAASDKVFSGAGDVWPAPAPDMPKIVSLDVKCEKNAMRVFLSFDKPFFGIVFSKGHYSNHQCVHLPPNLGRTSASFEIGAHACGTAGSGDPRYRGDVAAAGTYFENVIVIQYDPQVQEVWDQARKLRCTWHDQYEKAVTFRPFPVDMLDVVRADFAGDNVGCWMQIQVGKGPWASEVSGLVKIGQTMTMVLAIKDDDAKFDMLVRDCVAHDGQRAPIQLVDRRGCVTRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSMEVHFQCTIQICRYRCPEQCSDGNPNVIAPHAEYGPPQIDAYQQVGIEARRDERRVRRQRRATSPEKEVGVNRVIRVVSAGDLNMDTSEESTAPRVIPTPGLVCMTTPGFAATLGALLATLLCSCAVSAVLFLKLRPISTLKKKTAAVTTIPRPHPPTAHVISKSRFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIQ6</accession>
    <name>A0A835GIQ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIQ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003486">
        <property type="entry name" value="Major sperm protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13605" checksum="9382BF3E810B95C7" modified="2021-09-29" version="1" fragment="single">MADKQLLYSTVKHVLAMATNRSGAAQRPNGAPQTKVCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ20</accession>
    <name>A0A835GJ20_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF98">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="26841" checksum="89F75FDED075C4FD" modified="2021-09-29" version="1" fragment="single">MVNHNTKGFRETSYLYALTAAGVAHSIARACAQGRLISCGCDPLGYRASHDPRGRAKVNKWEWSGCSHNLAYGIEFSKKFLDIREQVDDLQSKINVHNNNAGRSILASHMEVRCKCHGLSGSCQLRTCWRATPDFRAVASTIKRQYRKGLMVAQEELNNNPSITKFLRRRSTNGFGWYIRSGLSHRSDDEVGIVRLTCCGRGHALIRKSSIKPCNCTFHWCCRVDCERCRDDKWIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK77</accession>
    <name>A0A835GK77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16255" checksum="7EBCB882C58B0ECD" modified="2021-09-29" version="1">MMLLIISTLGENCDDILCANVFDEVCGMAELNDGTQIIKAYKNICFMKKKECELGSLMDVTIQQLYSCYTNPRVLLFMQKIAIMNSLNLLGSDLPPPPDTPRYSGQSGRRINSEQAEDMDDETLLKKHLEEVMILSLGYEPAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKW3</accession>
    <name>A0A835GKW3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Membrane-bound transcription factor site-1 protease</fullName>
            <ecNumber evidence="24">3.4.21.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Endopeptidase S1P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">HW555_005293</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="35">BAW_Kor-Di-RS1</strain>
            <tissue evidence="35">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.</text>
            <dbReference type="EC" id="3.4.21.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.112" evidence="24"/>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000008">
        <property type="entry name" value="Membrane-bound transcription factor site-1 protease preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055143">
        <property type="entry name" value="MBTP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057060">
        <property type="entry name" value="MBTPS1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057032">
        <property type="entry name" value="MBTPS1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF7">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23001">
        <property type="entry name" value="MBTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23094">
        <property type="entry name" value="MBTPS1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23090">
        <property type="entry name" value="MBTPS1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 27" id="KW-0645">Protease</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 27" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 30" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033049537" description="Membrane-bound transcription factor site-1 protease" evidence="30">
        <location>
            <begin position="24"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane-bound transcription factor site-1 protease-like N-terminal" evidence="32">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="31">
        <location>
            <begin position="202"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 third" evidence="34">
        <location>
            <begin position="477"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 fourth" evidence="33">
        <location>
            <begin position="605"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="926"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF23001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF23090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF23094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KAF9417712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115156" checksum="6A45895E08C55BAD" modified="2021-09-29" version="1">MGLTRKKLFIFLTGLQLLSLVFGDGLGVNVDTVCNSSISQRVNYEFNSDVVNSEHIITYKGYFPRSTRENYVTAALRNAGISNWTLLQRDNPAKEYPSDFDVIILEDEGRRALDALKDHPAIRRVTAQRQVTRTIKYIREDDCGPAGCLYAGWRNHRVRGPKSLRQPRENGGYTSRKLLRTVPRQITSVLKADLLWSLGVTGEGIRVAVFDTGLARNHPHFGRVRERTDWTGENTLDDALGHGTFVAGVIASRAECLGFAPDADLHIFRVFTDNQVSYTSWFLDAFNYAIMRKIDVLNLSIGGPDFMDHPFVDKVWELSANKVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIGFDDRIAKFSSRGMTTWELPHGYGRMKPDIVTYGSGVRGSSVNGGCRSLSGTSVASPVVAGAIALLASGVPRHNLTPAAVKQALCMTALRLPGPNMFEQGHGKLDLISAYQFLRKYEPQASLSPSYIDLTECQYMWPYCTQPLYYSAQPTIANVTVINGLGVSGRVKDVSWHPHLPNGVLLSVSAEYSPILWPWSGWLALSFSVIEEGADFDGIIEGHMNVTVESDDDSGEKIMRNATLTLPIRARVIPVPVRSRRLLWDQFHSLRYPGGYFPRDDLRAKHDPLDWHADHVHTNFRDMYRRLREHGFYLEVMGCPLTCIDTSLYGALLLVDPEDEYFPEEMAALKKAVDSGMSLVVFADWYNASLLRHVKFYDENTRQWWIPETGGANVPALNDLLSMYQVALGDRVFEGAFRLGGHPMYYASGTHIHSFPEHGILITAPLSDQGHQIMSGEKPGGGGGASAGAQTVDVPILGLLQTDGETRDYTNDTSDRLPKAGRLVVYGDSSCLEGGAARNCHWLLLAALQYALVGHLPSSLKDAATPHQHRLRDVHIIPSELPQRAEGGRLHVYSRVLSPDGSGPRPVPECMTPTPVRPHPIHAPPSARTLAPRHQPTDPKSIGAPDIEGTEPAPRTWRGAGAAPSRAHGGAEHQSPSMASRALTLLAIIAVVYCLTAAWKRCGRKLRRRRLMSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKY0</accession>
    <name>A0A835GKY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="449" mass="49287" checksum="5B67ADCCB3E11D5E" modified="2021-09-29" version="1">MGRSKGYQDLDDSHIRPRSPGPPMPPPQEIEMASVSVVPDDTFTVTQAVNALGFGWFQVKLSLFTGLCWMADSMEMTILSILSPALHCEWNISKYQQALTTTIVFMGMMLSSTFWGNISDRYGRKTALSMCGVLLFYYGLLSSIAPNFLWLLFLRGLVGFAIGCVPQSVTLYAEFLPTKQRAKCVVLLDCFWALGACLEVALALVVMPTLGVHWLTCSVNYTATWLPESARYHVASGEPDKALATLEQIAQDNGRPMLLGRLVCDDSVGIGQRGRLKHLLIPHLRNTSLLLWFIWMACAFCYYGLVLMTTELFETGPSGLEEPCAADCRPLQTTDYMDLLWTTLADRTFLTCILFLARGIIAGLFQAAYVYTPEVYPTALRATAVGACSAVARLGAMVTPYVAQVLLKNSIVIATSVYSLVAVLAAVACLALPIETKGREMRDTVTVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLL6</accession>
    <name>A0A835GLL6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLL6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16189" checksum="DAF3DA2A7457BBEC" modified="2021-09-29" version="1">MEIDESGLLTGYETCEEAFMAQRNSLRPFHGDSIKQFQHLNVNSSSHNPVSVMRNASTDSWVEGMTATKSPRCDTDNKISVMGQGTTRVTLAGVLATHIQFPRAQHAFVNVWPFLITRLSLEIGITSSTNFLVDDVNMDMQQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM77</accession>
    <name>A0A835GM77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22828">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22829">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="3">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="456" mass="50550" checksum="BEB625A8B657519F" modified="2021-09-29" version="1">MFTALLLDTLKIIQRAVCNDETVALACPRGTTISIQVAQYGKAGEEQGCPALDPELAEENKNCKRPNAMQYSLLQTVVEACQKKPQCKFSTLPMAGLVDPCPAQSKYVEVAYKCRPYEFRSRTGCEGEMIKLSCNPHSRIAIFDAQYGRTAFEAITCPQTQGVPDETCVTPHAVKTVIQLCLGRRRCQIPASNKTFNSSCNYLSRPYLKVVYACVPLGVLSEKYESASEGDEQTTNFDHTKALFDESEEAGEKWGEPNADRALQPSVSDFNVPTTRQEVEVTTIQQPKKTADRNEEPPHSNSILVLSVSIGLLIFIIIIGAFIAIRCYINRRTNLSKNGDMYTTEAPNVFNDAFSDIDNDADISHISGTFHDPMHPDMILYKNVPGTRGTLRAMKPLCTIYPSTAEANMYGNVDYVPSHPTAPRFTRSRSNEEEVEPSVMTSPRSLGAHSSNYYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMA0</accession>
    <name>A0A835GMA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9419040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="57308" checksum="F9083C86F7694885" modified="2021-09-29" version="1">MLRQQLGQKVKQQAVALHKDDTITTMQYAVSSLQAKAMWPIIALSVLYLFFVLNSKFGRPRLYPPGPTPLPICGNLLSVALKLRSNIPHHVLWRSWAHIYGNILGLKLGFINVVIVSGKELIKEVSTREVFDGRPDGFFFLMRSFGKKLGIVFNDGPSWSKTRRVVLKYLKSFGYNSKFMESYIAEECRALVKLRTGDAGQPILVNSMFNISIVNILWRLVAGKRYDLEDRKLKTLCDLIMRLFRAVDMSGGILNFMPFVRHILPGLSGYTELTSIHKALHDFLRETIQEHQQNIDVNNPRDVIDAFLIEKIECKDQFYEELQVVCLDLLEAGMETVSNTAVFMLLHIVCNYDVQRKLHHEIDDIIGPLRPPALSDRTSMVYTEAVLLESLRISSVAAMGIPHMALDDARLGDYIIPKGTFILLAMFDLHNSPHWTDPDVFRRRRCIGEGLARSELFMFLTHILQKFYLKIPDGETVPSLEPNDGLSLSAKPFKIVFESRNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNH1</accession>
    <name>A0A835GNH1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNH1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13935" checksum="FC1A50D7A0E8D1BA" modified="2021-09-29" version="1">MKHKTSMGKTEKEIDVTLTERQFVRRPGCFCPFGTSNGPERTLATDRLAILLNPSDALWLPLVVLKTNSPEAFYNNFHITDRNSVERAIDLLRGRFRCLSQGAQLLSRHRCENGYCMLCFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA4</accession>
    <name>A0A835GPA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="177"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="441" mass="48269" checksum="AE0E82F8D258A3BC" modified="2021-09-29" version="1">MRRLSDLEQKSIDETSLDTGEELKMFKALPILLLVVGAHCQGNGDLDSVLNQIFGPPPTNNNPTPKPQTSTIVPPIQNNNGAEEDLSCKLPDGQEGECVSYYLCNVNNNTVITDGVGVIDIRVRDGPCASYIDTCCLVPDKRPPDQPVKPQPKPDQPQREGCGWANPDGADLRTTGEINGETKFGEFPWMVAILKIEPVNENEPEGQKLNVYVGGGSLIHPSVVLTAAHYVASAKALRIRAGEWDTQSTKEIYPFQDRDVASVVTHKDFNKGNLFYDIAVLFLAQPVDLAPNVGVVCLPPPKTRQDDGTRCFATGWGKDKFGKEGRYQVILKKIELPVVKHDRCQAALRKTRLGRFFQLHSSFMCAGGEPGKDTCKGDGGSPLSCPIEYEKDRYVQSGIVAWGIGCGEDGTPGVYVDVSVLREWIDDKVVGKGFDPKTYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA8</accession>
    <name>A0A835GPA8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPA8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="620" mass="68067" checksum="8A9C4A6B553D9290" modified="2021-09-29" version="1">MSLSIATSPCWSQLSGASGITPSSIVAVIQCFAAAKLFFIDNLPLEPLPNNDSDEFDFIIIGAGSAGSVVANRLSEVENWNILLLEAGGDPPITSDIPGLQTALYGSKNDWQYTTVNNGITSQGLKDGSVGWTKGKMLGGSSSINALAYVPGNTQDYQNWYDAGNKEWSVEHVHRCFKKAENLQNEAMLEDPNIKDVYGHEGHCIINKFNHTLRTYTDYVVESWDKIGFEKVSDLKAANFLGSGVIMATATNGVRQSTNKAYLQPVRDRPNLVIMKDSLVTKILINETLSAYGVEVEKDGEKKVYYASKEVVLSAGSVSSPQLLMLSGVGPKEHLESKNIETLVDSPMVGQNLQDHALLPITVYGDAPGKLSLLELMGDILKYITKREGLLAQSSIITDVAAFYSTVENATFPNIQNHVSIINKNNILLKSVLRATFRYNDTIIESITNFNKKHALYFFEAILLHPYSKGNISLQSNDPKDPPLIYANYFDNSRDLDVAVAGIKMATKILETPYFKMINAFLGRMDVPECNEYELDSEDYWRCICINLVTSIFHPMGSCKMGTDISTSVVNSRLQVHGVSNLRVIDAGIFPSTISGNINGACIMVGERGSELIKEDYNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPB1</accession>
    <name>A0A835GPB1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF68">
        <property type="entry name" value="GH19763P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032402619" description="Gamma-interferon inducible lysosomal thiol reductase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23825" checksum="5BCC8ABCF07D1DD9" modified="2021-09-29" version="1">MLRLSLLVIVFIVALKQVTSDAPQKVIVTIYYESLCPDSKRFILNQLEPSIHTLENYITLEFVPFGKARSINQGHNGFQCQHGPEECAGNMVQSCALDLMQERNDLEKVLYVTCEMMTEAGTTNNMKCVKRAGLRAYDVRSCISSGIGTSLQLQAEQATNQIRPRFIPTVTINGVFDQQIQDSAMVDLYGTLCSVLGEVPPCVNFNGGATEYAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPB7</accession>
    <name>A0A835GPB7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002952</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPB7"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="301" mass="33768" checksum="DB74201BCB7817E0" modified="2021-09-29" version="1">MAKASESAIKSIGTVLNDPSRPMKERFRALFTLRNLGGETAIDCISQCFVDESVLLKHELAYCLGQMQDQRAIPVLRRVLEDKNQDPIVRHEAGEALGAIGDPNLRELLEKYQHDPAVEVAETCQIALQRLNWVANDSSKEVNLSKSLFTSIDPAPPSSENDVENLKNTLMDESKPLFERYRAMFSLRNLGTTESINALGEASSALFRHEVAFVFGQMQDERSVPFLKKTLEDTSEHEMVRHEAAEALGSIATEECTEVLQRYLNDPRPVVRESCEVALDMSEYENSPEFQYANTLLTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPS8</accession>
    <name>A0A835GPS8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nitric oxide synthase</fullName>
            <ecNumber evidence="13">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_003066</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces nitric oxide (NO) which is a messenger molecule with diverse functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="13">Binds 1 FMN.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPS8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000033">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 13" id="KW-0288">FMN</keyword>
    <keyword evidence="3 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="15">
        <location>
            <begin position="436"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="690"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9420880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128986" checksum="E3A913AB9CBC3997" modified="2021-09-29" version="1">MLTITLIKYFFLLQNTKCSEKVCLSSIMSIPGREEKVRTPEEVYQEAQVFLRQYYASIRRENSEAHRVRLEEVKKELDEKGTYQLKSSELVFGAKLAWRNATRCIGRIQWKKLQMFDCREVTTASGMFEALCTHIKSAITIFPQRTDGKHDYRIWNPQLISYAGYRMPDGSILGDPGRVEFTDVCLRLGWKPKEKTAWDILPLVLSADGKDPEYFEIPREIIMEVHMDHPNYEWFNDLGLRWYALPAVSGMRMDCGGLEFTATAFNGWYMGTEIGCRNFCDSNRFNILEAVATKMGLDTNMSVSLWKDKALVEVNIAVLHSFHRDNVSIVDHHSASEQFMKHMENEGRARGGCPSDWIWIVPPMSSSLTPVFHQEMALYYLRPSYDYQEPAWKTHQWSKSDGVKTVRRKFHFKQIARAVKFTSKLFGRALSKRIKATILFASETGKSEQYAKELGTLFGHAFNAQVQCMSKYDMFSIEHETLLIIVTSTFGNGEPPTNGEDFAKHLVEMLNNEKENQDDIMEMCSAGYKTPAKSPALLRTNSFLASSRDYNRQLTRLESNKSVVTATSSVEHIAPLSNVRYAVFALGSSAYPKFCNFGKFIDNIIGNLGGERIMELCCGDEMYGQEQRFRTWSSEIFLESCRTFCLDESDMIREAQNALGIIPVTEETVRFGRPAAELPLINALEAGFRKQLVTYKVKENKTLSEHKETNAQTIFVDLKPTSEIKYVPGDHIGVMPVNRKEIVDAVLERLRGVEDLDKIVQLKIMKETLTPTGTVKTWERYERLPPASIRNIYTRFLDITTPPTTKVLKYLAESCTDEAETKQINELVTDSNKYHDWISFHYPHLAEVFAQFPSCRPQASLLATLLSPLQPRFYSISSSLLAHPQRVHVTVAVVVYRTQNGEGPVHYGVCSNYLKSLQPGDEIMAFIRHKSSFHMPKDISAPLILVGPGTGIAPFRGFWHHRRHLIKELVSHNPGPVWLFFGCRYKSMELYKEEKEEAVLDGTLHKARLALSKEEGDHRKYVQALLEDEGAEMTRLLVEEHGHFYVCGDCKMADDVEQKLEEIIQKHGDMTEEEAKEFIASLRNENRYHEDIFGITLRTAEVHSASRETAKRTRIESLKSQTSTGSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ86</accession>
    <name>A0A835GQ86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein charybde</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_008626</name>
        <name evidence="4" type="ORF">HW555_002704</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000776">
        <property type="protein sequence ID" value="KAH9631124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9631124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17513" checksum="0175816E1646E59E" modified="2021-09-29" version="1">MEILPVTNQFVGFNSEKAWNGPTWREAPVPVPTEAALAQRLERELRAAKGASELATAEVLVPAELLARASRQTLALAEGEPCGSRGAAVIVDVAGRRLAAFKIDPNTLTTHEIHLHLEHDATNWTSLLPQFLKNLTRGGTIIISPQFTIEKKKLFRSQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQD6</accession>
    <name>A0A835GQD6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQD6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06759">
        <property type="entry name" value="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="321"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="410" mass="45095" checksum="3E20E5F4BB63AD28" modified="2021-09-29" version="1">MITMGAPAWGSRGGGGDRPRLLRMTPLRHSFAAPASPPAPPPQEGWNANLSQRWRKLRRRCSRLRPGSGNREPSPVRCSPSPPRPPPHCSPAPPSKLSFRHRGKVYTTASLRVTSGAPDILRALGKLGGGLRRRALSAHDVLAPPQQQPSTFYVPSPTATRHPPSPSPPRQSASVRRRCSSPNVYRAAKDSATSRDRAPLISQEDESRDVVDYNYVPERRKNSSEGRSRRPYSENVELDVPYRNGYNRLPCEASQRLWEEPYRLPRVQSRQDSMHQLRNGVAELRVSATPRSARPPPAPPAATQTGKRPPAPEPRDTHTFEVRFTKSAGGKGLGFSIVGGRDSPRGDMGIFVKTIFNNGQAAESVLREGDEILSVNGRGTAGLTHGEAIRLFKDVRAGPVLLRVTRRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRH9</accession>
    <name>A0A835GRH9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000008">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="9">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="546"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1341" mass="148702" checksum="5F4C0778A2784A0C" modified="2021-09-29" version="1">MSSKKGRRHGNKHFPIAESVSIALKIQLDKFISDENETELKFPTFLSAQERGFIHETVAKLGLKSKSRGKGVNRYITIYKRIGSTIIQNDAKLILDSNMRCTIKELLSAFPVTSKEKDDLSSCPEKERSPQLTHKTMGQLNNGVAQVPNTQYNPDLMKFREKLPVYEQRQELINAILHNQVIIVAGATGCGKTTQLPQLVLDQCQEQKLPARIYCTQPRRISAVAVAYERMEKIGQSIGYQIRLESRVSPRTVLTYCTNGVLLRTLMAGDASLTGVTHIFVDEVHERDKFSDFLLIALRDALPRCKDLKLILMSATMDTQIFSRYFNNCPVITIPGRLHEVQRYYLEDILKISQYKTPKMAQVEKELKAKLKSGNSYWSHLEGQKQDDAGNSSKDVKEDKENMIEPSLQADMDEFLDECFNEGTLDSFTQILYMYISEGVSVHCAHSVSRRTGLMAAAARGLAETIAQMLQIGADPTAKDKDGKTAYDYAVENNHADCAKLLSTFNISEDPKGSLDDDNAADNFLLDVYHHTISEELIDHDLMLALIKYIHVNLPKGSILVFLPGYDDIVTLRDMIQSCSEMNSHKYQIFTLHSNMQTLDQKKVFNPLPNARKIIISTNIAETSITIDDVVYVVDSCKVKEKYYESGGGVCSLQCVWTSRAGCQQRAGRAGRTAPGKCYHLCSRRRFSTLPLNSVPEILRVPLQELCLHTKLLATGNTPIADFLSKALEPPSFLAVRNAVSLLKTIGALTPMEDLTEIGQHLLDLTVEPKLGKMLLYACVMKCLDPILTIVCSLANKEPFQISMNPENRKKGSMARKEFAADSYSDHMALLRAFQAWQTARANGTERAFCAKNLICGATMEMIVGYRSQLLAQLRALCLVKARGSGDIKDVNLNSEKWHVVKAVLVSGLYPSIARVDRDSSTLRTSKEVKVAFHPSSTLHQGGGLTGSQKSVHNLPTDWVVFEEISRAGRFCFIRCNTLVTPLTVALFGGPLRLPNSALTQRANPPGLSSDSDSEADENNASPDAAVITIDDWMAFTTDAADALNVFYLRQKLCALVIRRMSNPAKPMTPLDEQILSTVVHVMGAEEKNVGLNQPSGIGQRPKPLTVDSPNWRSRLENDEQYRHDNKNYYPQYNQNEGGYPGGNFYNNAYGGYRNGQGRPGGWRNDVPQPFSPQSYSGPKSPMSPNGKTLLANIEKYGEGGEGNVRYFVAKADDAHTVELAQNTGTFPFSQNTAKKLQKVRQEGSRVIIFFSCASAFKFVGCAALQEGGALEWITTGHVPFHTIRHIGNSLAGGARVCTMRDGAELCAGAGRALLGAHQRRRHHAPRAIQKHGADCGPTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSE0</accession>
    <name>A0A835GSE0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9423003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSE0"/>
    <dbReference type="OrthoDB" id="6605633at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9423003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="221" mass="24941" checksum="46950591925C70C9" modified="2021-09-29" version="1">MADQGYEIKPIQPGDTEESLQLLRRTFFIDEPMNQAVGLCSDGNCPELDEYCAHYLHENGWSFKAVDKNGKIVGLIVSGMCNLKPTDDGSDYVSQAQQCKNPKFAKILYVLAQREEGAKLWEKFPDQEEVLDVKLAATDPNWRKRGIMNKLLEATEKLAKQRGIKVLRMDTSSAFSAMSAERLGFTCMYSAPYTEIKMDGKPLIVPEPPHVDDRVYTKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTS1</accession>
    <name>A0A835GTS1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxisomal multifunctional enzyme type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTS1"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="12">
        <location>
            <begin position="658"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="10">
        <location>
            <begin position="804"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="11">
        <location>
            <begin position="960"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9424791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117283" checksum="80723432518F96A6" modified="2021-09-29" version="1">MDQLRFDGRVAVVTGAGGGLGKAYALLLASRGAKVVVNDLGGARDGVGKSNFADAVVKEIKDKGGIAVADYNNVVEGEKIIKTALDNFGRIDILINNAGILRDRSFTKMSDQDWDLIHLVHLKGAFKTTHAAWEHFRKQNAAKMGLVGLTNTLAIEGAKYNIKVNTLVPTAASRLTEDILPPEMFEAMKPDLIAPVVAYMSHESFPDTGAVIDSTLGYATKMHYVRGQGAVLKKKPSDPVTIESVREFWPQAMDMKNAIHLDKMAEVTVDLVERIQSVIVTRTRRTLVRRSICRSQLACYRKMASNNFRARKLVHMVVNTDVCHDNSVRNTELSTSTLTIEIEPEDTKKSEDEIFTDRQDIASSQDVVNADFSLNLSSAALGDIRVSDYSFSKDESFGLLCNETLTHSLMGSPVADFGTEDEPTTSQGLQEIENQRSNESCPDVDNAPTTSNNQILVTDSVMQNEDNEAANRLVCDALKGTTKKGTPRIRKLYTESTNTRKEAKKQKKIEKFCVKPACTTSCKKKCGEKFSESDRMNINQQFWGLNYESQGYYIQSLIKKQLVNRRLQISTLSRNNTFKYFLEKANEKFETEHDGELREIGFLKMKHIKSHSIPDPIQNSSPRGITEARKSAIISTLTRDFEERSKLDPDGKSYWSSYNYNSKDLALYALGIGASVLNEGDLKFLYESHENFAGLPTFFILPGMAIESPLVANAMPPGKFADFTNILHGEQFIEFVDEFPGTEGEFKIRSYSVDTLDKGSSAISIVNSEIYQNKKLVARTQQHIFVLGQGGFNGPRNSKHAVEVQPAPKRAPDAVVEQRTAEDQAALYRLSGDLNPLHIDPTVATASGHKKPILHGMATLGFSARHVLAKYGGNEPSNFKALKARFVKPVLPGQTLVTEMWLEGKRVHFQTKTKETGNIVIAGAYIDFKNIVSSQGTSSSAAAPAPAPSSGALKSDGLFHKIKEEVGKNKELAKSINGVFLYNITENGKTAKSWTLDLKVPEVYEGQPKSGKADTTMTLSDSDMVDLASGTLNPQVAYMKGKLKIAGNLMLAQKLGPLLKSPAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTU4</accession>
    <name>A0A835GTU4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000534</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTU4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032468881" description="Fucosyltransferase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="187"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9424395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="385" mass="45655" checksum="A1C9E653CC089DC4" modified="2021-09-29" version="1">MVRLMKYLKLMFHVSILVLINNFIKNQKQTKIEKRIERYIPDMKHILMWTKLPNVEEEGQQYFITHKCEHINCYFTSNRSLLMDLRYFDAIVFNVQDVSSQSSDLPKVRSTVQKYIFAANDSADNYPVCSPVYERFFNWTWTYRLDSSIPYKFISVYNIHDEELGNNILWENFEMKPVSKLFISSLSSKSAAAAIYLDKCTTISRREIFLNNLKICLEPYNLTVDVFGPCGNKKCGRTSLRSCYYRIRTTYYFYLAFEDSIATDYITKSVLFGYNNLAVPVVLGGAEYSRYLPPYSYLDGVKLGERLTAKLMYEAIQNKTKYYEFFNWRNHYTIKESNVLDACSLCQLLNSEGWLKTRETYTTFRNWWNSNYMERCKAEKRLNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUP8</accession>
    <name>A0A835GUP8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="83" mass="9498" checksum="ACB8FA1CCC4D6780" modified="2021-09-29" version="1">MKHPNIVTGGGIAVTSLGKEVFIIMEYVDYDHKSFLETMHVNGQMFTSEHVKCLMTQLLRAVQHLHDHLVLHRDIKTNNDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUZ7</accession>
    <name>A0A835GUZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10975">
        <property type="entry name" value="CE4_CDA_like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF8">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="236"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="615"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="942" mass="107177" checksum="9B07DEF518CBDDB7" modified="2021-09-29" version="1">MRTHGDSEKHRSVLMAVYYDSNVQNRIWIRKSSTNNNPITNYASSNKLCGAPCGTPKTGIDQKLLYAYNSQSTIRMCDMTKRIDNEISNRKNYPHDSRTTTYEYQAEFTIADVLSGFKRCAGWNQKKEQRSPLLCLSLFSLVNAHLTKKSLKDRLSGFSRKLQAISRSQNCRISFSGETATMKFVGLLALLLVSAVALAEEEEVEEAPECDLEACKLPNCRCSGVDIPGGLSPRDTPQFVTVTFDDGVNVNNIITYRNILYNRFNSNGCPAGVTFFVSHEYTNYVLINELYNRGFEIALHSISHQIPQTYWRDATYDDLKKEIADQKVQMSHFANIPSNSIKGVRLPFLQMAGDNSFQVMADYGLEYDCTWPTTTQTNPGLWPYTLDYKSNQDCVVPPCPTSSIPGVWVKPMVAWSDLQGVACSMVDACFFIPDRENEEEWFKFIMTNFERHYLGNRAPFGFYVHEAFISAYPAVQRAFVRFMDVVNNLPDAFMVNAHEVIDWVKNPVPIDVYKKQGCRRFTPTNCNIASCSPPPAAHNGVQYWMQLCNVCPRVYPWLGNPLGQMRVTILVSVLFLGLVSAELPLAKECNEELCKLPNCRCSSTDIPGGLLPRDTPQFITLTFDDGVNIRNIETYRDILYNRTGANGCPIGTTFYVSHEYTDYALVNELYNQGFEIALHSISHRTPTDFWASASYKDIKEEIIDQKDLIAHFANIPRESIRGVRLPFLQLAGNTSYQVMADHGLEYDSSWPTSALLNPGLWPYTLDYASIQDCPIHPCPSASIPKPWVQPMLSFRDEFGFPCAMADSCFYTPQFDDVDAWYKFFMRNFERQYLGNRAPFGFYIHEWYLVAYPGVKAAYIKFLDTVTSLNDVFLVNHGEVLDWVKNPVPLNEYMKKPCKTWTRTGCDPNPCLCVAEHNQNMYYFSMCTKCPRVYPWVGNPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXN0</accession>
    <name>A0A835KXN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000503">
        <property type="protein sequence ID" value="KAF9407132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="46583" checksum="FFC3F0D46C2E9AB0" modified="2021-09-29" version="1">MADKKCEGNKVCEVSKVLETFGRYQIIQYSLICFPAMFVTMININYIFAAGDINYRCRVNECEDQNSTFYPAWWPNQTIDRCSSPVLLEDHTQPYCTNQSFTEELKTCTEWIYESNNTIIAELNLACQPWKINLIGTIHSTGMLVSMIVSGWMSDRFGRMPTFIFCVVCGCIGLIKTFVTSYYVYVVIEFLEASVTGGSYAAAMVILVEIASARHRLLSGVIFAYAIYLGECLFAVIAMFVPYWKTLLRIINGPLIFFIFYIFIIYESPRWQIVNGKIEKAKESIKRIAKMNKINIDYEELDTITDVELKYKFDIAENQVKEGYSEIFKSKVILKRLLVVGMCRFTSSFVYYGLMINSVWLPGDKYVNFLLSTVMSFPGEIISLYLMNKYGRKIPLMAGYFISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY26</accession>
    <name>A0A835KY26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000431">
        <property type="protein sequence ID" value="KAF9407835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY26"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032310459" description="Cuticular protein RR-1" evidence="4">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11224" checksum="646C88D5642902DA" modified="2021-09-29" version="1">MKSFIVLALFVAAAVAAPASPDADAVVVRYDSDNIGVDGYNYNVQTSNGISQQEQGQLKNAGSENEAIEVRGQYSYTGPDGVVYTITYIANELGFQPQGAHIPQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYE9</accession>
    <name>A0A835KYE9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000696">
        <property type="protein sequence ID" value="KAF9405696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="12674" checksum="7EBCBBBF3C780A6D" modified="2021-09-29" version="1">MDSLMDIQDDVKSKIDKAIINFKKCPKDRLTLSALENLETEVERVSKTTRALHVVKDKGVSCAFCAATTLLSFVKTLSSARCANAATTHCYTHKVFLGRKLARVVVLLARNPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYS3</accession>
    <name>A0A835KYS3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_011530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000351">
        <property type="protein sequence ID" value="KAF9408954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052810">
        <property type="term" value="F:1-phosphatidylinositol-5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903426">
        <property type="term" value="P:regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000057">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043548">
        <property type="entry name" value="PIKfyve"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46715:SF1">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="13">
        <location>
            <begin position="251"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="14">
        <location>
            <begin position="1408"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="683"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="855"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="940"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="944"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1255"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9408954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1517" mass="170748" checksum="C7AE7834D993B538" modified="2021-09-29" version="1">MILIMDKYDTSQITEFPRYEPESSQSGVSTFFNKLWKFPLFSPSEAVDNMANKAITDGKDAPQNEEQKQDYNDGKPETGAYAEELEGRSLPNVLRRISSLIALGSGGGTKYADTELARYWMPDDISRECYECASRFSTLRRRHHCRVCGQIFCSRCCSQRVPGHIFGCAGGLRVCNYCCNVVLSYLKENDMTGEIPPDLRTLQENLQVKFPENKSQQAHKLRDSFMFPREQEERCEPRPQHETLHDVYRHLTYSLPTQQHRYRLVRYNGVWRGCDILQWVMDNTSNKTRAQATLFCQNLLCAGYMECMTELPQFVDYALYKPIVLPPRATDEENSPAESTRLVESASSSSYCLDLNLDENSARLTKTPKAEKKSSSSEEEPPVLEQNEAPAEAKHICKAIVESGEEHLRLLMRQCLARHALPAAWLQVLYPLCLQAADTIVLDVNSNDIDVRNYVQVKKVPGGSMRDSCLVQGVVLTKNVAHRGMPQQISNPTILLLDCSIAYQRVEGKLTSLEPVLLQEREYLVRCAARIAALRPRVVLVGGAAARGVQDALRSAGVALAAHVRGRALARAARATRASPLSSIDARVGMPRLGTCNNFYVKNYSSKTLMVLEGCAEPNLACCILLRGASLQELIKVKKVVKFMLLACYNWKLEKAFLGDIEAILPEPGMTFDDDVNDNEVSKDDIVKNDITNDDTQSDEREKDDIKRKDSLNEESRKSNETDSTESSRSDNIFTNSSVKDTEKVDDKAVAPNNEDKVDKEVKVSLGDDPLQTTKPFGRKTESDKTLSCGVPIRDFSDPLRATLSVDDDVFLPKEEAKLKADTHTDRWSTDDVVLSMSPNVVIPAPYLESEAGLRGGLRGQLPRPRPSAPSPHAPRLSKHDVRTSQSLPQLKDLHPFAKMAITAPADDPALKAALAHYRATGCRLVNDKHKPHCPMYKPSVVKRVKEPEQDPNEKSNDNEPLDPLAPENHQQLSLLFYSFSNKSANVPDFCVNPRIVTMEMYGELDISLGAFLDNYCFNNDYKCTSPNCNVPMNQHVRARRRMHHNYVQHYWPQQRRQDQRGIEQAGHETFSGLSEGDAEKDYQAFKQHMEQIHLALTSTSLQEHNTTAAVVRSLWSVSDRIISGEKMLREAQDKWSSPPAKNKAQTENAVEEKSELEDSSGDDSNKDNLEEDEEKGDKKTVRQILSQLLSNNQPANQSGMILWSGVVPVMVQAGDLGSVIAATLASVTYRRTRTVHRHNTQTDQEENENTSSTGKDKADGDKSKLKSNDHVEDGLVCRVYYAAQFQRLRHMVLRPLSSPAGEDPAAPPCPAGHRPSCACYDDTKDRADKGLCEIEEGFIRSLAHCVPWAARGGKSGSTFCKTKDDRYVLKEMTKPEWQQFLDFAPHYFAYVTHCRQNKLPSLLVRWENPLYVQSHTARMLFAAIERDTEFLSSHTVMDYSLLLGIDNHTLVLGIIDYIRTFTWDKKLEHLVKKNLGSGQPTVVSPEQYKSRFCSAARKYFLQCPSHWDHLYSNIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ40</accession>
    <name>A0A835KZ40_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000315">
        <property type="protein sequence ID" value="KAF9409482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1529" mass="174469" checksum="0D4A6DBF708DB1EE" modified="2021-09-29" version="1">MYKHSVDSVASYSSQNHVDRIRAQNFSAASCQDEGDFGSIKTSLFRRSSSNLEYPNKRPESVTSNTSSTRSRLRELVERKSSQDDHKSAADTVGDIQYFENPAETLEFDKPRNSLESKKSQEERPKKRKLSKGKDKDKDRDFCENKNKKHEKYQSKLAEYYKLPVQLPQDEFYQHLTRSKAAEELIQKRFSNSDTEFSGSYGRLCKHKEPEGANLRRSRSLAVIREETFTDLQIQNHAKSKRSQLIPRARLFDKPCFKDRLPGRAKYQTKEEVLESIYIDSTASCFGDINAQKENEKPDNPENRAEKEDAVSHNESQHSRSVCGSWPNLNEEIKQTNLSEDSIGHSRNPSEIDSLDSNYVRKHYNFEAHRKNYKESSPESDRSITSPIPSKELYVTTDEHATDNEDKERSKNTTPKSFTNDSLTRSEKDKPDDPEPISYTETYDKLSVKSVKSKNSERQTSLEPAEVTKIDESKNDNDVQSLASENDEIVSSPPDSITSYISISIASSDKSHKLEYLANSLAEKIDEYCDSQFKENTSIASNTLNSEHNNQESDPIYTQVNKKKTFADIRRDSFLKKNVIEKKPRLGIIKKHYSLRQRDPTEEDEIIRIPSPETVEKSINKTNSDTTAQKPPTTEETKTHSLLSRVQSFKTSAESNIAIVPLSGHQTIVIDPPLSQKSNENSRIESNTQREVETKPPPPPTEVKPVIEDTAEHKFEKPPPKLIIKDNKNCPEQSLYTFRKINTTMTRPQVLQVIDSKNKKQNIVTKMENNCETNSPVNKKLDNPIESKEDAKDLKGDNNVKEKLNNAIKTDIEYQEKLNSVKNYWSKLIDKNPDFNENINKPEIKINQEDFNNNKDGDLSDNKIEKDQQKTEDSKLLSEISVGNIIKTLESVKIVDSIRKISQTKLQLWKDETEKVKSDSEIEESTLDKIVKDCDTNFYDKSDLAKSEIDLCRDTPEIEIVELSSDDNQNQKTQATLIKAKGYEKGCDDFDHELFKNSMIANYRKEAQFDGLLQYLQDYSFQELLVNNNIVIIEPVRTKIEPSPRKNTDTCKIPPTLLKKNDSNANLSDKPKNAVRRHFFYHPIRVNKEIIEEELPNPDTVKKVRNLFEDTLKMKSPMTHDPPLVNENLGLTRRATSYRSLNEESKGTKNGGRKKIIRQLTIDTNFGNKKWDNASLSSGVSSGDLSSNNEYETDGLSPYSQKNLKDNAYSSSEEYLCDSMNQDFCCESQYVSPDILKKIRECGTSITYYGGKVLTSKTGSTVSPMTKAIMEEIKSLQKNCSRDCYSCQTKCRGDKCSCLVADKHKQMLSEKQNSNTSLNVVNQNQDKRTESFPGFKFKLVKSNSCSSRLELTGTDDSKNPRNKFKKQLSREDPPLVHDDENSVKNKICRLESYSKGIVKTPFDNKDSGIKKDLVKSKIEAIKQNDAAVKKKEAPVQHIAPVVESKKETTITEQQEGCSEDAKANNAQGDKQASNAQTFEKKFYYVNDNLDQSKVTTGKFGEMVFEEFEVLESCYDNAESSVEEDFQREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZD9</accession>
    <name>A0A835KZD9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000755">
        <property type="protein sequence ID" value="KAF9405348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZD9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032698718" description="Citrate transporter-like domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="196" mass="21797" checksum="4D4D70D4D83AC7D5" modified="2021-09-29" version="1">MWNYRVSLGWMALLGALLLLTLADREDLESMLHRVEWSTLLFFAALFVLMEALSKLGLIGYIGGWTEALILRVDESDRLAVALILMVWVSGITSAFVDNVPLTTMMVRFVTSLGTHPTLNLPIEPLIWALFFGVCLGSNGTLIGASSNVVCVGLAEQHGYKITFMQFFKIGFPVMISHLVVAIAYLLVFHCVFSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L058</accession>
    <name>A0A835L058_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000563">
        <property type="protein sequence ID" value="KAF9406664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L058"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="19072" checksum="FF8BF22BC5A6A2DA" modified="2021-09-29" version="1">MPAQHAAVERGGVPRGGHHLRLLLRGEGRALALQRHNLSLCTPPALSCEPHIRVLISTSSLLGYVVYQDPKLLFGGIDLLLSCSLPIVSDIIRGLAPRSSPHDIRFSIFGVVSKKRIVYIVPDSSEGSESVVPSGGQCGRAPSRSTEHDVTPHSRGADMPRISDAEASVNNRQGCVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0G9</accession>
    <name>A0A835L0G9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000295">
        <property type="protein sequence ID" value="KAF9409832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0G9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="158" mass="18027" checksum="56BCC7A7B2DBD236" modified="2021-09-29" version="1">MTALQSALQPTKYKKPWVFISKCLFVKTKQRKKSKTGAVLTTAGLDRIIQIKYIDATTRKTETKYKLEDLEKAVHDVRNKILSLGKASIIYSVPKSTIHGYLKKEIINEPKTGRKAIFTDARKLHKLWAHENCTSDKIQDSQKNCYLANKVAIEMQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0K2</accession>
    <name>A0A835L0K2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000484">
        <property type="protein sequence ID" value="KAF9407332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0K2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="177" mass="20544" checksum="160E7EBFACFD090E" modified="2021-09-29" version="1">MTQFQYDQELFSVLILEWIVVDLSIILALCVQYEKFHLALDEAESTCIQLLMSANCSSKYTANFGIYTDHLMISNTAHRNGMFFQLPHYWVHNGLSVKPHLRYDKIDQVVFPILIMAWIIMEAAVILALCVQCEKFYMAVEEAESTCIQLVMRTKCSSKNIYFKFCKFPFHTFLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0X2</accession>
    <name>A0A835L0X2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Survival of motor neuron-related-splicing factor 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000261">
        <property type="protein sequence ID" value="KAF9410482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0X2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20149" checksum="2D8F164414A827C6" modified="2021-09-29" version="1">MADDLTNYKLQLLQVEGALLADGDNEELLKLKADLEEVIELTQDLVKAQDGDSKACNTHGSGNGRGAAASVLAAKDEGSSHKHFSNSQVGETCLAKNGKENNKEYLMKKEQKKQQRLKQYEKEREAGKNKWLNFHSKAIKKPGVRAKSIFASPDNLTGRVGVGTCGISGRPMTGYTVGEKWKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1G4</accession>
    <name>A0A835L1G4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">formate C-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_014448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>formate + acetyl-CoA = pyruvate + CoA</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010001043">
        <property type="protein sequence ID" value="KAF9404232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1G4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050244">
        <property type="entry name" value="Auton_GlycylRad_Cofactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30191">
        <property type="entry name" value="FORMATE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30191:SF0">
        <property type="entry name" value="FORMATE ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000379">
        <property type="entry name" value="For_Ac_trans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0556">Organic radical</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="13">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="12">
        <location>
            <begin position="625"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="10">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9404232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="748" mass="84094" checksum="917E6315B4C48A3C" modified="2021-09-29" version="1">MEQWKGFKGDKWKTSVDTRDFIQRNYTEYTGDDSFLEPIAPSTDKLWTKLQELFEVQHEKNGVYDMDNNIPATITSHEPGYLIKEEETIVGLQTDVPLKQAFMPFGGINMANNSLTSNGYEVDAEMSKIFTEWRKTHNQGVFDAYTPEMRSARKNKIITGLPDAYGRGRIIGDYRRIALYGMDFLIAEKKKDLSNTGNKVMTDDVIRLREEISEQIRAMADLKEMASTYGFDLSKPAENAKEAIQWLYFGYLGAIKSQNGAAMSIGRISAFLDIYIQRDLEAGKITEFDAQEMIDHLIMKLRMVKFARTPEYNQLFSGYPIWATLSIAGMGLDGRSLVTKSDFRILHTLTNMGPSPEPNLTVLYSSHLPVGFRTFASKIAKQSSSIQFENDDLLRANWGSDDAAIACCVSATVMGKDMQFFGARANLAKAVLYAINGGVDEKTKMQVAPKFRPMTGDTLDYNEFIDRYKDIMDWLAELYVNTLNVIHYMHDKYSYEAAQLAFMESNLQRTFATGIAGISHAADSVMAIKHGNVQVIRDEDGLAIDYIPQNEFPTYGNDNEEADAMANWILEYFMTQIRRQHTYRNAKPTTSLLTITSNVVYGKATGNTPDGRRAGKPLAPGANPSYQDGKFLGEKNGLLASLNSTARLEYTSALDGISNTQTINPNGLGKDDDTRIDNLRNVMDGYFDKGGYHLNVNVFTNELLLDAQAHPEKYPNLTIRVSGYAVKFRDLTPEQQADVISRTSHDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1L5</accession>
    <name>A0A835L1L5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Splicing factor 3A subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_000569</name>
        <name evidence="18" type="ORF">HW555_010407</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Interacts with HTATSF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000258">
        <property type="protein sequence ID" value="KAF9410558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000278">
        <property type="protein sequence ID" value="KAH9640625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1L5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001216">
        <property type="entry name" value="Splicing factor 3A subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="17">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9410558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9640625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="30062" checksum="CA18841AAD5C53D1" modified="2021-09-29" version="1">MDFQNRPGGKTGGGGVASWSESNRDRRERLRQLALETIDLNKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQANLARRAAKEAKEAPQQLAPEKPRIEPKKFVKIGRPGYRVTKQKDPENGQQSLLFQVDYPEIAEGVQPRHRFMSAYEQKIEPPDRRWQYLLFAAEPYETIAFKVPSREVEKHDSKFWTHWNKDTKQFFLQFAFKMEPLRMPPPPPKMWENHGMRLPPPPGAPLMGVPPPPPLLPVPPPPPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1P3</accession>
    <name>A0A835L1P3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000332">
        <property type="protein sequence ID" value="KAF9409167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1P3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="7" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032787084" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="330"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="61354" checksum="1030F1E65884015E" modified="2021-09-29" version="1">MKFTWITWKTQAMAFKIYALLLVAALSTNEVFSASQTSIEDVPNMAQLETGTGVAWLQTCVGSIITNLHILTAAHCLLGAAIEPRTSRVRVGTEERGRGGYLQSFVRHPTYSNTHFDGNVALVRIQGSLTFDSKVQPARFAAPGLVFPPNVPVNVVNWGRTAQDTIWSDRNLYSSLLYTVDHKACAEKYASLSPVSIKVTDNMFCVREPGTLGTNFGVRDGGAPLFYNGVQVGFVTIGSPIGEDFPLVVTAVSPYTNWIVETASRLSFKNIVDLPYQKFCKTQTRNWLIEEIGLGVAQLIGDLKAKSISTMVSARFATLFLAAGLCVSGVLSASQAKIEDFPSIAQIETGVGRAWLQTCVGTIITNFHVLTAAHCLVGTALIPRISRVRVGAEERGRDGEIFAVQSIIRHPDYSFRSFDNNVGILRLRSSLTFDTNIQMASITAAGLVFPANVPVVLASWGRTAQDVIWSDRDLYSTQLYTVDHSACVEKYGSLLLPIEVTDNMICVSSAVATGTHFGVRDGGAPIFYNNILVGFVSFGSPYGENYPVVATGVSPYSDWIVENAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1U1</accession>
    <name>A0A835L1U1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000241">
        <property type="protein sequence ID" value="KAF9410915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1U1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41588" checksum="95A5FDDD1ECAE5A5" modified="2021-09-29" version="1">MAPLVECHKCKKHVDIKTTALCSVCNHRYEPDCIGYPGQTYRMMHQESKKKWKCVTCIKNKNSISSDLTNITLRNKKKPVNTQPLNQAIIIEKHQPVDASQIHDSHVLTDCNSSSESDYTPPKMSKSLDGTSSDLNSDLISLSEMKDTISQLTGELNCTQSELDKTLLENHDLQKQVNKLTAENNMLKSLCQSTSLPDASFRSSIKKKRHSLAYCTTSTPSSPIYSSNANYENKTISLKKQIEDLQLRLDRANLEISALTKQIETLSQYLQNKTEVLNPTTFPRNHEHRLEKTIFIFGTQQCVGLALALLQSRSNTKYEKYGILAETNPNAKCDIIIQNCIKTTLKPNDKLVICIGKMIITWGKFYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2X3</accession>
    <name>A0A835L2X3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000238">
        <property type="protein sequence ID" value="KAF9411022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="120"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="36132" checksum="2AC7730086D9D2A6" modified="2021-09-29" version="1">MQTVKWIEMVRLGPTTTETTSTYDDEKSKMFRLLRELVRIVAAKVRKIEMIVFNASVKRRGTIHSVCDRGTLGHAARRRGTIHSICEVLSMSDELRRALYSSGASIDMEFSPPDLIGTSEVLTMEHREKLCSVLPARAQGYMWQLAFSTSQHGFSLASMYRKMQRVDSPVLLVIQDTDNNVFGALTSCALHPSEHFYGTGESLLFAFQCSGEEARRQSQAAIDSAKDKDNKDDATKDDKGDQPPPVKTKFKYWGWTGDNMYFIRGSNDNISIGAGDGKFGLWLDGDLYLGRTQRCKTYGNEPLTTREDFIVKIMECWTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L361</accession>
    <name>A0A835L361_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L361"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="55120" checksum="4B72A7E6C5E855FA" modified="2021-09-29" version="1">MSHMMAGRPGGESDSDPDDYYGFLEKPPRNYFQYQQQDDKKKLEMDLQDAIINGNLAEVQEIVTTRLNNNVNTRLDSGWTALMHACFHAQDAIVKYLLDEGADPNFRADSMTPIMTVCSNSNASNEAIYNIVTNLLEKNCKLNCIDNYGQTPLMKAVGCGRVDVVQKFLNLGVNIEVRDLQGWTALFWAAHHNQPQILEILIARGARMSEVDKYNRTALDLAELHEYTEITEILKRHLQIPEEHEDSFYMEITTWHDFYPGIKKGQSPDYRSEIPHLLYGMHLENFTATIMKTGMDLRTFLLLEESDMLKLGMDLPYERQRLKCGLRNFHKRNWKLKAVSGLAFQDIENFSMLSYLTSLGSHLHQIYVLEATLQYTLREYNKIQDQIKFEPPESPIRDKMVNAAKKMLTNIDSIKRASGRVRIILEKIAENNPEPADLIKEKSTQDIVLGYFTEAVVVASLCIMVYHARHWFSYFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L375</accession>
    <name>A0A835L375_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_007511</name>
        <name evidence="7" type="ORF">HW555_008712</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000880">
        <property type="protein sequence ID" value="KAH9629026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L375"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051776">
        <property type="entry name" value="Integrator_subunit_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415">
        <property type="entry name" value="NUCLEAR FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9629026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="25851" checksum="3DC2979554BFD450" modified="2021-09-29" version="1">MSSIDFDPAIKLCLKYLHSSASDSTEQLRLTLDDHIRQTYGSSKTLGNVLPKKYLNEEKLESPRSKHKTEKSSSTKTVALPQQSPQQIQIPERENDDGSVMDGELSLDLLEEDLTCAVCRQISVQAGNRLVECDVCCALYHQDCHKPVISDNDIAAGWQCASCLASQGITGNYIKATPKSPSNISGSSTPVKISSSSSSSSSPSKVVTPNINIISADKRLQIMKKKAAKQHEKKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3I6</accession>
    <name>A0A835L3I6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="12">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_007565</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000005">
        <property type="entry name" value="Solute carrier family 27 member 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF21">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 1, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1713"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="17">
        <location>
            <begin position="1520"/>
            <end position="1618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9414558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1774" mass="198095" checksum="1E5479FB227EC566" modified="2021-09-29" version="1">MERRESGNFAIPPPGNPDGFSPPGLSICRLEPCCCQTTFLIELDNDLTDHHDLLQKQNVAKSYVIKMSNVEMSVDSNMNKTDIIQHKFEVKNGNADIEKGAVVKAGPKIPWTKAIIAMFALGVLAGACAVAWVFQDWQASLLVLAILAIVYCIAFYWRWIYVAIRTAPRDFSALYCYIKILRLTKNFTKKNWSMPDIFHQMVVKHPNKACFLFEDETWTFRQVEEYSLRVSAVLKGKGVKRGDTVAVMIGNCPEMPSIWLGATRVGAVCPLINTNQTGNTLLHSINIAKCDVVIYSDEFQTAFQEISKELSPSLKLFKFTRRPLNTSPDAVKVVESDNDFTAMLENTAPFAWTPSDSDGFNGKLLYIYTSGTTGLPKAAVISSSRMVFMASGVHYLGSLRASDVIYCPMPLYHSAGGCITMGQAFIFGCTVALRTKFSASKYFPDCIKYNATAAHYIGEMCRYVLTTPPSPTDTQHKVRTVYGNGMRPAIWTDFVKRFNIKKVVEFYGATEGNANIVNINNKTGAIGFVSRIIPAVYPIAILKVDPDSGEPIRDNRGLCQLAKPNEPGVFIGKINPNNPSRAFLGYVDKAASDKKIVKDVFNYGDSAFISGDILTADELGYLYFMDRTGDTFRWRGENVSTTEVESAISRVADQRDAVVYGVEIPNTDGRAGMCGIVDPQGTLDLDKLAKDIAKDLPKYARPIFIRIMASVDMTGTFKMRKVDLQKEGYNPSLVKDKLYYADPKTGKYLPLGNEEYEKIVSGQIRLRTNVRVNELNLVIVRTARNRQTVTVGRRSAVRRVTLRKVVAMVLVLAALGAACAALFFSQGFLCMLVSIIILGVVYLLAFHNRWCYVAIKTTPRDLRALLSYIKILWITRKFSSKDLTLPDIFHDVVNRHPDKPCFLFQDEVWTFKEVEDYSLRVTAVLKAQGIKKGSIVGLLVNNCPQQPALWMGIARLGAITPLINTNQRGNALIHSVNVAKCDALIFSDEYQSAIQDVAKDLSPSLKLFKFSQRPLKTSNSKFEGSGDGIADFTNLVETTSPAPWTLADAEGFQGKLLYIYTSGTTGLPKAAVISNARFVFMATGLHYMGLEGNDVFYCPLPLYHTAGGVISVGQAVIFGCTVALKTKFSASQYFPDCVKYKATAAHYIGEMCRYVLATPPSPADTQHSVRVIYGNGLRPQIWKDFSVTEFYGATEGNANIANVDGTPGAIGFVSRIFPKVYPIAIIKVNQETGEPIRNSKGLCQLAEPNEPGVFIGKIQASNPARQYLGYVDKAASDKKVVKNVFHFGDSAFISGDILVADEFGYLFFRDRTGDTFRWRGENVSTTEVEAAISRVADHRDAVVYGVLVPNTEGRAGMCGIVDVDGSLDLDKLCRDLARDLPVYARPVFIRVMDSLDMTGTFKMKKTDLQKDGFDPKLAKKDRLYYLDLKQGRYLPLGVEEYDKIISFKNYLMVWDMLEKNYIKCIFSRYAALRACECVASFVVRKCEFYVLWCESVIIYSVVRVFVNGDMATKEKEILSHIIEVYKDMPYLWNKNDKNYMNKTIRSEGFEVLLSIYKNIEKDATVKTLKKKIDNLKTNYFKELKKVKASKHTGAGSEDVYVPTIWYYDSFSFLETTTESCRSIRDTIEDEKEAPLKQQDILEKASELLNTKEEDWEILGRSIGMQLRDVNQQQHIIARKLISDVIFYATLNKLSEESFLAAVRPTGLPASMDAILAALVALMALAAAMAAVLSTLSKAAIFVILAVAPCVYRYRRHIYVFIKTLPRDCKGRFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3V7</accession>
    <name>A0A835L3V7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="11">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_009093</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3V7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9412424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="845" mass="97633" checksum="CCC20569E5EA3054" modified="2021-09-29" version="1">MGVPAFFRWLSRKYPSVIVECIEQRPTDVDGELVYIDSSLPNPNGVEFDNLYLDMNGIIHPCTHPEDKPPPKDEDEMMVAIFECIDRLFRIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRASKETQEKIDEIARIRSELLAKGAYLPPERPKEAHFDSNCITPGTPFMDRLSKCLHYYIHDRLNNDPGWKGIKVILSDANVPGEGEHKIMDYIRRQRVQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFKPNKPRPCDVCGQLGHEMKECTGTNPDASLVRSDPAFGNQDNFIFVRLSVLREYLERELQMPDLPFPYDFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVNLYKKCVYKTRGWITDSGDVKLERVQVIMTELGHMEDEIFKRRHQNEISFKAREKMKKRQQQRVNFEMLEKTQFAPMAVGQNQNQNKPLENVRREAANMRVAGMQNEAAQESENRGRKRSAQAAGLDDEDDDDKNDEVRLWEQGFKERYYESKFEVARDNLEFRYRVALQYVRGLCWVLRYYYQGCASWKWYFPYHYAPFASDFVNICGLSTKFEEGTQPFRPLEQLMGVFPAASSTHVPKPWAKLMSDPFSPIIDFYPTDFKIDLNGKKFAWQGVALLPFVDEERLFKALEPYYDDLTEAEKQRNIRGHDRLYVGTANASYSFLLGLYSSAGGRLRQLIEEKHKYPYRCDGVTGDVMLSRDCVVIGGQLPSPVIGLQPVLGNHVVCVRFVDPAYDKEFPARRLEGAQQPPRVLKPGNLSHEENRNWRPQIGMVRSNTIASMEEAGRRMLGHHLPRSGGYATIPPPQQHRKYTVTLVIIIVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3X9</accession>
    <name>A0A835L3X9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3X9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="3">
        <location>
            <begin position="152"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="564" mass="67242" checksum="54A194427A275DDF" modified="2021-09-29" version="1">MNVIQPTEKIKIENKKMKKLEDEHLWLQRQVRIIQIDRQHRTMGVHPQFRRQDMLMQTLKKEYLNLCKDLKIARSGAHKKKDKKMKIELQKSLLFRVAAQQKCDAHVSMMQQYNDLIQKNYKETMNLRKLASTTQGEIEERRWQSEYRLMSAENKLEAAKMRFNAVQYENKKIREEIEHMLRDRALFNQAWNKMQAALSKGKKFLYDLFESSTLAYDQRDEWCTKLKTMQEKGKIDQDVTNAVHPSFEMRDLVKAFDHEMKVYQFLATKGMARVNKTQELREEKQRKLDEENRKKQYQYHVELLDEISEYTGENSTRRILDQFKKKEQENFSIYVILTEYCAENEVLRRDVQDIRQQIYDRREWMEQKENRLDTKIEDLRNLLAEQKARTDALRKKNEEKDQLIQKFMNHINDMFTRSIIVSKIWLDGVHEPYTGSLEEASNTSCTVGRCNFKLIGLVEHCLKKSNKSGRLKKYTLREEPQTVFKPTHITTLVPADPCPSCVEARWLSRIFDGTELPFDKNMALNALKELSSDPAYMRSDRVHTIMECIVPRSRAILARRYVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4C8</accession>
    <name>A0A835L4C8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticular protein CPH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4C8"/>
    <dbReference type="OrthoDB" id="7483159at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032411046" description="Cuticular protein CPH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16003" checksum="DA71854F57F0D039" modified="2021-09-29" version="1">MRFLIAFVAILGYASASVISPYVYGVNAGDAQAAAIDATVAAQDHARAVGESQARAAEAAVQFNTEAVRQVAEANRDLHENAYWGSVAANQNAVAAAQSHAAAASGVAAAHAGIAAARAAYAAPYGIAAPYGIAAAPYGFAAPYGIAAPYGAHALGYHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4M6</accession>
    <name>A0A835L4M6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Octopamine receptor beta-2R</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HF086_017244</name>
        <name evidence="15" type="ORF">HW555_011417</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000337">
        <property type="protein sequence ID" value="KAF9409120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000134">
        <property type="protein sequence ID" value="KAH9643463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4M6"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15066">
        <property type="entry name" value="7tmA_DmOct-betaAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000271">
        <property type="entry name" value="Octopamine receptor beta-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="54"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9409120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9643463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="45260" checksum="908EA3725A77973B" modified="2021-09-29" version="1">MDRENFTQYAVRNATANATDNSTVAEIDEDLTHSLFYRLRMSVLLLIVIMAVLGNMLVIVSVMRHRKLRVITNYFVVSLAFADILVAMVVMPFNFSVQFANKWLFGPTICDLWNSSDVYFTSTSILHLCCISVDRYYAIVKPLKYPIKMTKKMAFIMLAATWLSPITISYVPIFMGWYTTSDHLKVQKADECEFKVNKPYAVISSSISFWIPCTIMLFTYYAIFREANRQEKNLHARAGNAMLMHRHSREVGDKNGALHINATTPTKDRNILKMKREHKAARTLGIIMGAFILCWLPFFLFYVSTSLCTSCKCPEVVTVIMFWTGYFNSALNPIIYAYFNRDFRNAFKNTLACAFCSFCRRSASDLDALERLDRRGSAQLRVPVPSRRTSDLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4U6</accession>
    <name>A0A835L4U6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Angiotensin-converting enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_006092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4U6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF44">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032439297" description="Angiotensin-converting enzyme" evidence="11">
        <location>
            <begin position="22"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6 8">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9416583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="82264" checksum="747ADF83683FDEDE" modified="2021-09-29" version="1">MSPTLTLFCIFFYALLSPLQCGTSSSADDDRRWLVSLVDLVELDYVDHCEQRANAAWNELTGNSKGLASKLERDKTFGMFVCQQTTDIKSALTAHALSADDHVLRRKVKLLLQPGDTLLDTEQWIRLVTFGDNAQHKIRFATNYDCGTATNCTLKELHYYMARQQDEETLHRMKQSWERNLPDINDYLEHILPLLRNASKKNNYNSVEEYWDALGEYEGAILKARELWENVKPLYLKLHKYIALRLKGSDAVGKPLPVHLLRSLTGDDWSNLIESLLPKHAGIYQKVHANLQLKNLGGVEAFKQAAKLIKALNLGDADPDIWTESVFNSTCPPTLVDWCKPNKVRAITCKDVSIANYIEAHEAVMKIVYKQTINLHSNNTYILREASRYSAVYEAIPGFVSLLSVNPHALSKAGLFPVETFNYNANHHRLVLQLIMALRDLPKLNFYLAADEWRIKVLMGAIPYAKIPSSWSDFRKNFSNIETADSDFLGDPYMMFNKPFIGKFMGLILKYQIYQSFAEELISDDSDLIKHVAENNERLIDAMMQGYGTVWPEMVSDLLAKREYGLEYTGLTDYYKFLDEYLDNQLEPSTDTSTSDDYVEPVEPEPVPEENEIPSSAENQENKNVDKVETHEDIVDNVIDTGDESNSKFGVETSTVGVLEIKNPVAPGDQKEENTKEASYSTYWWIGIAVALAVVVILIAIIARKRHSHRKQLERQRKNNSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4W5</accession>
    <name>A0A835L4W5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_007952</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4W5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000003">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000005">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000032">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="301"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9413999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="587" mass="65575" checksum="54586763B7E8FBD6" modified="2021-09-29" version="1">MPTISVKRDSLFAALGKTYTDDEFQELCFEFGLELDEVTTEKQMLMKEQGEHVGAGVSEEILYRIDIPANRYDLLCLEGLVDGLLVFQGKKPPPHYVLKKYEDCHSLHLTPATGQIRPFAVAAVLKGITFTKESYDSFIDLQDKLHQNICRKRTLVAIGTHDLDTIQGPFVYDALPPSEIKFKALNQTKEMTAPELMELYSSHAQLKQYLGIIRDSPVYPVIKDKNGVVLSMPPIINGDHSKITLDTKNVFIECTATDLTKAIVVLDTIVSMFSKYCSKEYEVEQCKVFAPDGAYELYPKMCTREETISVEKANNYIGINENGENLARLLSRMCLSSTTEDDGTTLRVRVPPTRHDVIHACDLYEDIAIAYGYNRIVRRPARVVTTGGQDPINKLTEQLRLECAHAGYTEALTFTLCSRDDVATKLGVKIEEVPAAHISNPKTLEFQVVRTLLLPGLLKTLAANKKMPLPMKLFEISDVVLEDKKAETGARNERRLCAVHCGRAAGFQFVHGLLDRVMALLREPWDKDTGYYLRQCEDPAYFPGRCAAVVLRGEVIGKVGVLSPAVLAAFELTNPCSALEINIQPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5I9</accession>
    <name>A0A835L5I9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATP synthase regulatory component factor B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_003610</name>
        <name evidence="1" type="ORF">HW555_006235</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000337">
        <property type="protein sequence ID" value="KAH9639477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5I9"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9639477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31545" checksum="99CB9312E7A24B50" modified="2021-09-29" version="1">MSLTLRHLRLYRPVYAIGRQYSEDKTRYQILEEGQKPKLVHGKPYAEWRKPWIQRDGEFRSKLSVFVEKNPSPDILNFMSKLPNLTTQAIKDWWTDMKELQEIENQRYLPKRVATLGSNLAAAHFFTFRKCSIRLKDSKRWISGDATTLDLPDRYVNGYFIEAIDCTNFFHGGIRYEGLQNLSNLKFLKWLSLRNNKHVDVWGLDRVAGQNGDSLEFLDISGCQLCVGCIFALVRMHALKYVVLTDPGDNLNLQAALSMLEQERPDLMINAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6D6</accession>
    <name>A0A835L6D6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6D6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="70884" checksum="38DEDF56DF4ABD39" modified="2021-09-29" version="1">MLQDASQKRQRPRDMSLAEPPHTMEIAQILISLLHAWGLDPDLDRVCESKLGLLRPMVPVCFGVVSRHGHMAVQLPTWLGSWSAACASAPDDPLLITSDLPPELVRQEKLTRLFSSKLHWELSTTLTTNHLLSIVALANTLMSMSNASFVPEQEMIRRLHRNSSSWAADEEREEQLAAQQAHIKQGWSLLATLHCVLLPDKVVAAGAKSFKRPQVEILGPKGRKTLVDNWAQFLPLYTHTESINPHAAHKEPAEKIQQVQEEEFEEEEEEIIRKPSSLAELKRKQTTAVVLLGVIGAEFGQDITSEGAAGNKRRKDGDSRKSSVVEGFTLSSSNNLARLTALALTHLLLSPACPRLPAHTPLRRAAVDLLGRGFTVWEPYLDVSHVLLGLLEMCCDADKLVPSMTYGLPLTPQADSCRTARHALTLIATARPAAFITTMAREVARCAAAAQGGQPSAAYLALQKGRAEVLRGIELLIDRMHNEVAELLVEVMDIILHCVDQSHLKSKGLNEVFPAICRYNQVSHCPATRRIAVGSHTGQLAMYELRAGRCQSLAAHSGPVTACAFSPDGRYLVSYATADNRLSFWQSTAGMFGLGAAQTRCVKCYSTAPMADVARLNPARLARLVWTNSRTVTLMLGDGSETRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6J9</accession>
    <name>A0A835L6J9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004002</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6J9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000064">
        <property type="entry name" value="Probable arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="16">
        <location>
            <begin position="99"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="15">
        <location>
            <begin position="557"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9419502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="682" mass="77731" checksum="11C23BEA8F86D6A0" modified="2021-09-29" version="1">MSDHKTIEERTVQAEREAQAIEEELDKISRGDLSYIGDPQLEKLSTENEKLKHRLVILENAIKAECSGSKSTAVQKEPKKRPTLITDVNSVEGNICLVDELKNIFEVAITSAYPDLEDPPVVITLSGNNPKFGDYQCNSAMAISQLLKAKNVKTNPREVANNILNKTPTSPFIERIEVAGAGFLNIYINKMMAEHILNCILRFGVKPPPVKREKIIVDFSSPNIAKEMHVGHLRSTIIGESICRILEFLGHDVLRINHLGDWGTQFGMLIAHLQDKFPNYKTHSPPISDLQAFYKESKKRFDEDEEFKKRAYACVVQLQSHQADYISAWKLICDVSRQEFQKIYDRLDISIIDRGESFYQERMDVVVKQLKDGGYLEEDEGRLIMWGNPDKHEGIPLTVVKSDGGYTYDTSDMATIKQRVEEEKGDRFIYVTDAGQATHFVIIEACARRAGILKNNQKLEHVGFGVVLGEDKKKFKTRSGDTIKLIELLDEGLKRSMDKLVEKGRDKVLSPEELKQAQEAIAYGCIKYADLSHNRINDYIFSFDKMLDDKGNTAVYLLYALTRIRSIARTAQISQEQLMAEVEKSGFKFGHEAEWKLGKVLLRFPEIILKVASDLYLHSLCEYLYEISSAFTEFYDKCYCVEKDKEGKIVKIIYERLMLCEITARVMEKCLDILGIKTVSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6P4</accession>
    <name>A0A835L6P4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dorsal-ventral patterning protein Sog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6P4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052278">
        <property type="entry name" value="Chordin-like_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526:SF1">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50933">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHRD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="3">
        <location>
            <begin position="163"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="569"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="639"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="89935" checksum="F76BCA4BC3A50BFB" modified="2021-09-29" version="1">MESPDIVQEDSPVVITTEEDEKNMKYFASFLTGRSPLCVRRDDMSGVPVAHGVATARFTFRRRHLYWSVLLSPSIQAQPRALAFLDKEGRVLLEQSLKKIPGIHATYEEKTDKLCGVWRRVPRQYKTLLRDGDLHVALLWGDARNNSIDSALSGRIDRYPALSSEMFTTLLEPEHPPTSIGQGACRDYPALEYEDGWWGGTAVITAVAGATPSLYLALVFNGVFPKTAVTSHLVRVILTLPEKNQTIIDQVQRVSKPHYDFNVLEVSTPVSAAELRSLARGRLLLTVEAVDAPERRIVGSVRQKAACEVYNTPLVSERLSATPAPEGLALLYIDKEGSLVYDIQVDNLGITDPKITLVEEQGKRHSQVEILDTRIGVLARPSARIFQPLYEEQLAVHISADTGPPILRGRLTSRMLPDAAGSGPALLRRTGQVRLPAAMAGLAWLSVDSLCGLYYETVVTGGNARSWSSWWLGTHPGTEVAARELGGEEGWVLEPTSAELVALHLGASSLELRAHDNVTVILRARVPQISVPPSCLPTVPGTSDNELIPKYTPGPLEDQMTDYSLFRLNYCTQRDKFYKLGETWTDTETCSKCWCVLGMVRCEPVQCPPVNCLVPTIKPPGQCCPICTNSTTAVWSENGSCVLAGQSYAPGSSWHPYLVPGGYDTCAICTCNFATRQIQCPRVKCPPLRCSEKEAYRPDKKACCRVCPEVKAKKPDEETPKDQGAPRTAEEILAEGGCKFPDGPLPNGKEVHPSIHSHGEQRCVTCRCKDGEVTCVRKRCGRAACARRRRVDACCACTRHRRQRAPRTERPAPPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8A7</accession>
    <name>A0A835L8A7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_005984</name>
        <name evidence="14" type="ORF">HW555_004572</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000772">
        <property type="protein sequence ID" value="KAH9631213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8A7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="73"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9418744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9631213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="39293" checksum="0F2CF978EDF76621" modified="2021-09-29" version="1">MYKICLPSSKYRHIPKIKLLSQTILSILIYVELLFGNSVIAKQRPKKNELDFQEVLKENIQYPPMVDKCPLRIVGGQKVDINEVPYQIVIQTYLIRNAYWILVCGGSIVTQRHVVTAAHCFPRRLWNRKTYRVLAGTGKLGSTGQSKEVQKYPTIKRKILSCFRHKYYNEEEFKHDFAVLTLDSPVNFTENVQAIPMLQPSHGIQLQINGLCVVSGFGVYTNYKTSKSLRIVCVPIVSTSVCIKHYYNYLQNHQFCAGTQGKDSCWGDSGGPITYKGYLVGVVSYGAAQCGWSPSVYTRISSYTSGENVPFVANRCVTSAIYNLLYINNILLFFVYNLFSKHVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8R0</accession>
    <name>A0A835L8R0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8R0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032657450" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="371"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="533" mass="59271" checksum="38329525D6F62D67" modified="2021-09-29" version="1">MTVNILRTVIIFFAILQCTRAWGLKGYNKTLSNSIEVNWTNATQLIDTGFVNLERKMAVFAFGFRGSETTQDTDKFIEAALSNTDWSVVLVNWKDEAAPGGTPDYYGAARNTQIVGAQLGQAITSMVESGLVLNNIILIGMSLGAQICGKAGSTVKEILGQQLPFGVTEAGYRRLGDRKFTWRCFKCKQSNTPQPPSSPRPENESAILLEIRALSAKMAPLDNLKDEFSALRSEFAELKSSFHNHYIAMIDDLNNKINGMESRIAQAEKVQEQVASIRVRLEKLEEDSDNKDQWSRMSNVEVKGIEQTKNENLIDIIQKVGTKINYPIHKSQINFVTRVPTKDPENIKPIIVCFSNRYVKEDFIAAARYEIMGLDAAKPLFEPIEVFRCIKSSDAACVFLLHTDTNRFGVSGSYGTHNFFANRVFYALHSYQPGCNPIPTSSDAMSMFQTYDLTTELFCSHLRALKYLIEAIKTNCTMIGRKVSSGTLPSLSGTTTSIIACLGFNISQSEEGDYVFRTNAEPTYGMGLDGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L943</accession>
    <name>A0A835L943_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L943"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="19265" checksum="F0C72D2C99056176" modified="2021-09-29" version="1">MLVSTYKLAAEGDRGGGLLIPAREPDDSGIDSDDAVRRLILAHQRLPFSDESSSDDELQIPSPTTHRHRNERRASLKNLPEDHDLVIMQWPQEQYTKDQNATGETTPDRSSPPLYEVELTASDEDDDASVLELVIPMHSSRYQRVPTSSPKKSKPKVVKRYFCSMICCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA70</accession>
    <name>A0A835LA70_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA70"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="290"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="591" mass="64647" checksum="157A3AF44D69EF61" modified="2021-09-29" version="1" fragment="single">EMNGSTTTVNGSAVNGTTGALNGIGAAPRTATLGTPSSYAYTSSGSLLGRSGAARPVPPPTLPKYSGSFSAGSTTGLRERDREGTGGSHRLASLERLALRQRIIEQNSNNQVSVGSSVNAPPNGPTSATVTLTDTATVSVRVPLPSVGDSGTDKSKVGWTSPRDIWRNLSLRRKAELQSKRELFFKSDSVSGGGVSATGPPLAAPPAPPSVLKDALAKRATTLPDQLENNHHESNGTVTKLSNSVSKPDHPPVAPKPELPKLEKPKTKELDGYVGFANLPNQVYRKAVKKGFEFTLMVVGETGLGKSTLINSLFLTDVYDRDKHPGPSLRVKKTVGVETSVVLLKENGVNLTLTIVDTPGFGDAVDNSNCWQPIIDFVESKYEEFLNAESRVTRKAAPPDTRVHCCLYFIAPSGHGLKPLDVEFMQRLGDKVNIIPVIAKADTMTPEECKDFKEQIMKEISQHKIKIYDFPESTGEEVENLEHCDFLALRNMVIRTHLQDLKDVTSSVHYENYRCRKLAGLSHDGKPHRINSNKNPLAQMEEEKREHDLKMKKMESEMEQVFEMKVREKRAKLKETVDGKDKKDKKKKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAM0</accession>
    <name>A0A835LAM0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAM0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="48526" checksum="0AE3B5273804CD0D" modified="2021-09-29" version="1">MPATIPTFTYGIQIGWLSPMGPLLKSELTPAQEPLSDSDISWMAAALPLAAICGIPFFSYASDRFGRKICVILVSLLSCISWTIKLTAVLSPALISARVIAGLAAGGCFVVVPVYLKEISEDTLRGALGSLNMTMCKLGVIFVYAVGMATSYQANQAVYLAVAAVHVIVFCFMPESPNYLLKIGEEKKAAKTISWLRSLNRDHNQVVEELLKLKDEQRQFEETNRVSLLSVVRDRTTFSALRMTLMLMAMQTLSGCFALMNYAADVFHRAGTQWSPNTLALAVGSLQLAGSFFTTISIEKFGRKIPLACSSLVVSICMTTLATCFLLGTGVVSWLPVVAVCLCILAYGAGLAPVPMVIMAEVFPFQVRARMAGASMAFSFFCSSMTVLFYTPIANQFGPYVVFYTFAAVTLFGVLYTILWVPETKGKSLEQIQKYWRKTEPVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBE0</accession>
    <name>A0A835LBE0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBE0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="17129" checksum="148779648DA96455" modified="2021-09-29" version="1">MILFQTLYTFFLSLIYVQMLIELQQLKISHVGLFHINVITILTVLWLLKNVLYIMLFSTSCEHFYMSVTEANNTCYKLLKRFQNTVAVKSLCKNVLRSHRATFHKMTACSIFTVDADLAHGFTSLEVEYIIVLLQFAFTRLKYEVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEE2</accession>
    <name>A0A835LEE2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="19450" checksum="2258650963D3255C" modified="2021-09-29" version="1">MMSRHHEYRVVDVNASLSVSQTDDERVVAHLVSTLTKAPTEKAIFMQRTNTSYLEAVTLLVTQSIRHPFSKLLAASRYSRIRHLRYCIVKRDVSSIPTCSVTVSLSLMYHNLTLVNVRRSSVCHISSPFHQALALRGRRDQRPSCLVVRRGSTTPALPGTRPRRHIIDYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835FZY1</accession>
    <name>A0A835FZY1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="4 14">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_014297</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4 14"/>
    <dbReference type="EMBL" id="JACKWZ010000952">
        <property type="protein sequence ID" value="KAF9404531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835FZY1"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000010">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9404531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="29190" checksum="6BA588FDB28A1590" modified="2021-09-29" version="1">MAKLSELLKETTTFLKEKGIGEVDFGLILGSGLGELADEVEDAIAIPFSEVPHFAVSTVVGHAGKLVYGTLSGKKVLAMQGRFHYYEGHSMQKVTYPVRVMSALGAHSIIVTNAAGGVNENFIPGNLMLITDHINFTGDNPLIGENEDEMGPRFPDMSHAYTPEYCEVTKKVANAQNMSLQEGVYMGYSGPTYETPAEIRMSRVMGADAVGMSTVSEVIVAAHSGMKVLGISCITNLAAGMQSSLNHAEVVETTERVKAQFKELVKATLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1T5</accession>
    <name>A0A835G1T5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000635">
        <property type="protein sequence ID" value="KAF9406145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1T5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="177" mass="19700" checksum="6C72FC5D737100B0" modified="2021-09-29" version="1">MAPMATAFCCFRDPYMLPTTPCTNMCGCSANIGPTCECGTSCNCFRDLSNVCNVCDQQPSPVCQCLNKCGCDSKYPLYFPEVEYPLTILEIDTMEIVKADYGCSKSVANVIRLASLGVAGLLQERMCRISAYKSLNIDPRDIIIHHFNNPPNVHMLDIVSQNLPHYLPRLAEGRKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2B6</accession>
    <name>A0A835G2B6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000573">
        <property type="protein sequence ID" value="KAF9406585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2B6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="501" mass="59178" checksum="679430906C0E5392" modified="2021-09-29" version="1" fragment="single">MKIFVLFWYHLLENPEILEDFRRKFKKKKAIRKQSHESSASLNAVSASVEGDTYTRTLQRRYDLEYLPDLDPNFEELDSYKKKGEFGQLIPKNSEVQEDVAPQSDDENGPHLEPEINQNENLEPKSIFGESLPIIKSAEVEAITENIVEKKYLKKELVEHKKRKPKLTKPKIIEDEGDYDRGTYQRHSLEEISSERGETSTTDDINNDEQEVKSTESNYYKEKGNERKKRLKGEHKTKSAEVTNEQWNGNAQDETVDPHKKTKKLKNWNDPVKEDSNEENDSKERKPSTEWDLNGKNNEYKYEDDWNLKRDHQDEGKDVLNTERDDWTTKQENLDIKHDFDKKYEKHEDEWNEKNLDWEIEKDDDWTTKTYDTDNDIGKIDERQNIDKSDEWDGHDKTKRKDNWNKEARINREKDSWDAKDVWKFEYSIRTEQKKAVGPTNDGDNSGDDEIKEKDWKHNHTKTKSLKVGKIGKTSKKIGKDFDHVNDGTVDSVKQITTKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G379</accession>
    <name>A0A835G379_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_002903</name>
        <name evidence="6" type="ORF">HW555_013297</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000614">
        <property type="protein sequence ID" value="KAF9406272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000786">
        <property type="protein sequence ID" value="KAH9631004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G379"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9631004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="468" mass="53885" checksum="64E55DB3C7F5CD47" modified="2021-09-29" version="1">MLTPRFKLTQDENHVFITVHAPYTNIGDTEIDVDGEHFLFVSSPYFLRLRLPGRIVDNDSSKGSYICDSGDFNLTFDKETPGENFENLDMITSLLAPKDIPDMNPNLVEMLEEDGITLENENNEIIDYSNKYSYGFANKLTTEFSNIGSEFPQIFELRVPENVSIEERTAKRIKHENDKFSSDHYLADFYDEELLEPFLTGTVSWNEPNFNKEIEFTDDELGVLKELPNKNFLLSKTEYEEVLYGLVDILYAYCYDKRSTLNESTVESGWTINKLSATLSWFCTFRDMKEVLTTCYRRALIYPIFRNYDLCIKVKNDLVSLFKLGKKFIVKCMIEIHQLFNASNDARYILNQLYIRDYLIFLQKCRNEELDELCNNIANIEISKDDLELDIVELEEAAELVKQEEVDSIVENEVAVKMASMSLLTGLHRTNPVYIEGESDESDSSDSSDSSDSSDDSSDELDSDDDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3Q9</accession>
    <name>A0A835G3Q9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000622">
        <property type="protein sequence ID" value="KAF9406238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3Q9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="79"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="501" mass="55333" checksum="AD7B654B2824C642" modified="2021-09-29" version="1">MITPFTVYHGCWLQIARYLSPRYQNKVNTDNSGKHSAVDVSNGGNREHERTRWQTPDGDRLSTYPATGDRSTLLRSHAAKSAECSGQGSPRPRRAPRESRRVSLAQASGYVQLNQYRLLEPIGQAMKILSKRKLMRRAGLFGRAPPRRPGPGPPPSPLQRVYREIAVLKKLDHPNVVKLVEVLDDPAEDHLYLVFQLLEGGPVIDIPTDNPLSEELARKYIRDALLGVEYLHYQRIAHRDIKPANLLLGEGRVQVADLGACGELAAAGRVSGTVGTPAFRAPEAAAPADKYSGEAADIWSLGVTLYAMVTGKVPWIGSSAIELQRKVLAEPLTYPPKFQPSKQLRHLLSRMLDKDPATRATLQEVKDHEWITDGGKDPLPSEQENCRLVEVTEEDMAQVVTSIPNLSTLILIKTMLKKHSFQGVHQLSRESSEKSTAAAKRGGLARAGRSLSAPGNYLTESRQSSFDIGLESVQESRDQSLDVTAKEKSPQEKEKEESSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4X4</accession>
    <name>A0A835G4X4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000547">
        <property type="protein sequence ID" value="KAF9406788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="260"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="734" mass="80834" checksum="153F5BB811CB1099" modified="2021-09-29" version="1">MLNRIMKTSIPDNISMVEDHQVIWDQLRAQIDEVKEQSSTDLSIHDVHHYTVLYISVAAVIILGGVVVYLIRSRRAAARAAASPAPQGQEAAGAGRRQLAPVDPAPVASHQARSVLKCSEVFTVSGVDKASPESMMDTETIGDLLKAMRDAISKSTQIDDDVALPVFDPEKCDNGATRWCNNIETLAKDLNWSSIKTAAKAALTSVFSFQVTLNETMAGGNVVYESVPKDEKREELQKPPERPKGLGIRHLQTVILFICLTIAYTIRSQLSVLMVAMVRVQDPHCTLPDGTRNISEGCADPNANISRWNIYRTYDWHKSTQEMITFSFFVGYTSMMLPMGILAQKFGGKLPIMFALAVNGVISICTPWIALLGGWIAMSISRLALGMTQAAMYPSIHTLLAKWAPLRERGRLSTYIYTGSQAGTIIAFQLSGLFAGSPILGWPVSFWLFGSLSLMSCALLGWFGVASPHQHPSITSEELAYIMEDGAVDIVPKKRKTPWKHILTSKPVWGLIVSHAGSAASYLLILTEIPLYMNHILHVDLKRNGLYSSLPYIALYLLALVFGYAADFAANRKIMSVVNIRRTANTIAMAGSGVFLFAFSFINDTTWAVLVLIIAHGLHAGIHVGFHTWLQTFAGPVMALGNMIANLTSLLVPVIVSNIVKDDVTDHRKWQYVFMIFVAIMIISNTIFVVFAKGTVQPWNFYGEDENENGKELNGLEDKATKNGKDRQKAEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5B4</accession>
    <name>A0A835G5B4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000444">
        <property type="protein sequence ID" value="KAF9407696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5B4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="286" mass="33405" checksum="9C6D0E6FB34818F4" modified="2021-09-29" version="1" fragment="single">QYPYLSVHNGLNIVLYRRDKVIHPSTGHLGARNRRVPPPHASRSMSARPYKKSENDQGYGITKIWSTVPKPMRYKLWNEVVTELMNSDVKVSKSEMRELEIQLQKKWKSIRDCFQKYVANPNRTKKPYIYSRQLQFLLKDQEELPRKEDGGGTTESDDDRPIKKKKVWRSKKKLKLVKEESSEDDNDNSVNFEAIDDSRDYTLDTSETGRSAKVPKISKPQVDEFAFASVDTQMKTESDDPDRMFLLSLLPHLKTIPEEFRLNVKMDMMHVLRNASYNSAREHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5W0</accession>
    <name>A0A835G5W0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000578">
        <property type="protein sequence ID" value="KAF9406539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5W0"/>
    <dbReference type="OrthoDB" id="9984207at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9406539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="467" mass="52008" checksum="221ADF265E0D7F0E" modified="2021-09-29" version="1">MKSSKRRLQALTEGSDGLPNYLKMEDSETSIPPVFRSRLHELFSQIEKEFDLLYTENLNLQEKIDILSEKLERESYVGDKQNLDYIEFDVAGKNSKVKLTQSNSQKVKASHKLRVQTSKIVSSFKAPTYNCQLVREFTGHKDGIWDVTSARPGQALIGTASADHTACVWSVEWGKCLLQYTGHTGSVNSIRFHPTRDIALTSSGDNTAHVWQAAVNWDLPRGQSSEEELEGGGEESLGEGGDRPEVLRTPLTELGGHQGVVVAADWLTGGDHVITASWDRTANLYDVETGDCLQVLTGHDHELTHASAHHASRLVVTASRDTTFRLWDFREPIHSVSVFQGHTESVTSAVFTREDKVVSGSDDRSVKVWDVRNMRSALATIRSDSSVNRVGVSGNGLIAIPHDNRQVRLFDLQGQRLARLPRSSRQGHRRMVTSVAWADDIASNINFFSCGFDRRILGWSIQPSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5X4</accession>
    <name>A0A835G5X4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein Nup205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000430">
        <property type="protein sequence ID" value="KAF9407848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1690" mass="184483" checksum="8AC539F9FF93E454" modified="2021-09-29" version="1">MGTTADDLWTPFKELVSVVEGYLAHEGKGAPYAVHTFETVLRRHKQTFLSLFKNPAKNASSREEIRRGITEGVTLPSIGRTLLSKELVEEAIIISDMYNVSEYLALELLHTAQRQSPRHPGLPRGLVAVLLYYDGRRALVQALKELVMARDGVCWSINAREEIISYVSRYVEQLISDGLLSNALDSLRRFTLEVEMELLQNNRALPPGRHHVTLVSTIETTRKLLAGVVFAASAQKGLSRDIILRIIAEQTTSPTQGPTGALDEISLALQMALLYALDLSVLHRREDGEELAKKLPLIQDPELISVLLDELSGTPAEQGRGAGVRALCQLSLGLALAALKRAPQSLLRRTNSPHVKCELLDQDEMLVDAAIDGKVFEYLDEAILSTDFVAKEEYYQRRIHTLITDFIVLMHSKLMEMRGGRGGARGVDVRGGGAGGAGGRGRGAHAAGRAAALRGAAVRARPAAAAAPVLGRFVRLSGEVLCGALLAGYLRALASLAVPKHTWALLAKRDALSAYHLLTALARYHSNLRADPAPFSEHAHASSLGASAIVTPAARPGKMLVRQEEVEALIAALKLIASVAPLGSTPATAGRVWAALEAAQLVSTSNEKRALNAELHEVECRMEEYPLSRAFLVLLESLCAAAPLPRALGAGARPPGLDPYVEHVLNRLALPAPHRPYAKPTEKWQMLSLCFRLFARWLEAYEPSPSDFPAPGREADTNPPPGFRLLLQLHTKSELLRLLLTTLEEAHDLLEKHPQPATRVRVVTLDGPAGVRGACAGELPAGGGARAGAGAGAAGRRRRRGPRAHARAALQAHTRYGFVECLEAEEWSEPSVQAEGAGEGGEGVVEGAEGGNYVRQAKEGVLLLLQHVLPTAPPNLAHFLLGYNLSDDVSRSSLNEAGAAGYPRTCLHSILDILEQHIASHNREANNLVESCYRLVYWLCARPNTSAPILRFLRTRDYFLSRHVKATIDLKEWEWCLLRRTLEELPVSVEPVVEPRWELFQAQQLRQAIASCDLPTGLGGKRISVSRVHALLTRELAALHATAPQRNLVATEIQKVLDYVTEVNRQRNLAATLTHYYDSWRQLTEILFCVAPHDILPLESRKNLLLNILQDLLNKIPPAEVLPQLGNLASGTVLLLLVNLRHCYLLQKRETNQKSSEFEMSFFGPSNQIMQTNSLTLKFILHKILSWILVSGGSTQKMRVNLYGALLNYLNIVNLKTSPADPEEENMPTTYVSRLDSSKARPSREESALKSMVIDVISDFGENLCSIVCGDCIGAGHDVCRMVALACLDTLIEINPRTDWVNTLTNQGYLRSLIDSLLQDDEGLKETLEPNPKSLRVLYVYESKMGLLLKLAGTRAGAETLLAQGALACLAGLSALAAHPDIHTGYASHKDTEFVPSVANRFRQILVPALSLCDALLTTLGPQNHSCVLHVTHALLSHVECIDAVLRAAHPNSPVELLTEVEAITSVIGRASNREVFGGAVAVEPTALQASAAAAQRVRWLMLALLGRFHRPATDLPDQNNSNLLYYKIVCNLLTYARNIMCDSSGRCVGLAAAEGGAGGAGAEAGGAARLLALLQHLARAHAHHDKLLATTRHQLHNLPTMSLDDMRKLLPEESSSLSPVECRTLLNATGAWRGSGDDLPELRKELIAVFNDRFTEQLLDTTKNQPQVQRSFFELLVKDIKTMVQFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6D8</accession>
    <name>A0A835G6D8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000377">
        <property type="protein sequence ID" value="KAF9408536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6D8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="148" mass="16140" checksum="61A7DDC1B30489C0" modified="2021-09-29" version="1">MPIGKLEPFSLSSKQWPAYIRRVNQYILLNDVKDNLKVPMLITVVGESTYALMCDLCSPDFPENKTYEELVKLVADHLEPQRSEIAERHVFRLRRQREGEPLAERGRTRGARNTASAAGAPGAASTGRAASTDCAARPSNGGSAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6R2</accession>
    <name>A0A835G6R2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ALP1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000279">
        <property type="protein sequence ID" value="KAF9410078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6R2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="12363" checksum="946AC7F5B4FBBB25" modified="2021-09-29" version="1" fragment="single">MDSDTDFEENVAYLLMLSLLKKERKKRRYWVHPINTSRGSRSEYHLLVQELKSDEIKFQQYFRMTKQQFNYIHSLIEQDIKKIHTRFRRPIGTKERLAVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G774</accession>
    <name>A0A835G774_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000478">
        <property type="protein sequence ID" value="KAF9407367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G774"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032495342" evidence="2">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="99" mass="10931" checksum="F03BD1DDC70467F2" modified="2021-09-29" version="1">MQDFGEPAERVGCGGMHRIVLLMAVLTRAIAPFANVTGPPTTEPSNPPASTMMTPPPTVFRNLRVTSKPRKMKQGKVDSPMLNYIFDSYATSNKHFHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G776</accession>
    <name>A0A835G776_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000327">
        <property type="protein sequence ID" value="KAF9409246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G776"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="20623" checksum="5E8445C0F50BDE76" modified="2021-09-29" version="1">MLGMFLVREPVTATLWLSLWNTFSLPAPDSLSPNPGTLSFITVSPCPLTLSRARPKPLEVGCMLLFKSTEPIALSTFLSLCASGILAPKPMPPSELRVTLPCACLRALVRCCGWQDSSSSGSRSSCSNTGRSSSSNPRRCTCSYARWSCGTCLALAATSTAASINFRANIFLICLLLSWIKVYERRSRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7C3</accession>
    <name>A0A835G7C3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000253">
        <property type="protein sequence ID" value="KAF9410659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="199" mass="22657" checksum="D3A6B9B6648EADB7" modified="2021-09-29" version="1" fragment="single">FPKTSALEVENSELKCSRVAQTLSPAYSGSATGVRTIRVLRDRFRPHLCLTVFMCGYCFYRINRMRQNGEIAILLRPTKVVFSHKKEGQSAEELRTVVAYQNPFTGDYCVHKSRAGPKGYVNNLQPESPDSGVSDEYEPLNLEPVGPQPKLPHVELDKMPPGIIAMPQPDYTIKLQMSPNNDYNSVNKTWNWNYKEYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G809</accession>
    <name>A0A835G809_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000323">
        <property type="protein sequence ID" value="KAF9409361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G809"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38342" checksum="EDFBEBFB9755A091" modified="2021-09-29" version="1">MFAFKDGVAYPWSAGVSNMILYPEAANQTLYARRATRGDSGNYTCRLSNETHVEAHTVKLTILEKPTDAPRTMFISKDQWVEEGAELRLYCEALIGRSLLADARSDLRWRKVFPNNTEGDLLPTQTEIKTTRNDVVSKNYVTVHYIHDTTWCGSGSVPWRALALGAAAGALALLSAAALHRRCTPRLLLAARHARARAQPTARRARVLEKEFDVLVCWTAVDGELVRGALLPTLSLKYKYRVHAVPLSTQPDTWYSELVGEASRCRSLDLPKLKREAKEGGESLVSTLRGTRLVAWRHVHERAFWTALRLALPLPPAPARDTKPNPAETEENKYSRSGSLTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G852</accession>
    <name>A0A835G852_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G852"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="11885" checksum="E9C4B81D09E01CAB" modified="2021-09-29" version="1">MHLRSEDEACVPCWLRARRAKIAPPVDDLQTPTPDQVDGELSVLMCAVYGQSLTTTTSDGEWNTDNIARLLEHQQMSAMNEVCGVCWDHARDLKSGKKDLSILSCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8F9</accession>
    <name>A0A835G8F9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000348">
        <property type="protein sequence ID" value="KAF9408992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8F9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033101691" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="553" mass="62579" checksum="7C4085497CE28BAA" modified="2021-09-29" version="1">MQWRTCVLLLCVTAALADDEWREVKTAQGIVRGRKHPTEDIYTFYNIPYATAPVGVDKFKAPLPPPIWSEPYDAINQQVVCPQSILMPISDLQPVQQGNCLIANVFVPNTDEKNLSVVVYVHGGAFVMGWGDIFEATQLMNKKDIIIVNFNYRLSVHGFLCLGTEDAPGNAGMKDQVALLRWVQKNIASFGGNPDDVTIIGYSAGSASVDLLMLSKSAEGLFHRVVPESGGNLAAFSIQRDPVEIAKKFARQLNFTNVDDIYALEEFYKTAPLELLMSDPFFDKTDSTFMFGPCVERNIGEEAFLIESPLTTLKNGNFKKLPVLYGFAEMEGLFRIDFFPFWKQMMNDKFSDFLPADLKFKSEGEREHVANKIKRFYFGNGPVSEDNILQYVNFFTDVIFAYPMLWATKLHVEAGNNQVYLYEYSFVDEDVPVVPHTNIRGANHCAQSFAVLDGKNLTHLSHTDESLATPEYQEMKKTIREIWYNFIKTGKPVPEGSSLPAWPAAGADRSPHMSLGQKIELRGVLLEERTRFWDDIYQRYYREPVPPPAPQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8G5</accession>
    <name>A0A835G8G5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000390">
        <property type="protein sequence ID" value="KAF9408337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8G5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="252"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="358"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="7">
        <location>
            <begin position="432"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1278" mass="138080" checksum="BE30BA92CC45E31F" modified="2021-09-29" version="1" fragment="single">VQSPVLVVELNLDRIEGTQLRALGLLAVYGFNVTYEVRAAAQAPGPTSCSAIECRLLGHCYARQDFQEFYCSCFDGYSGADCGVGPLCPTTSNMCKNGGTCRQMGPAAVSCICAPGYTGDLCEAQVAPPECGIEECAEVCKDGTACDCNPKDTDALSARFETRLQVVGLPNENISDEIAKQLTQFLKASNITLEDDVQVLNTSVTTTEGIRDAWVRVWSSRREAPALRAALARLASARTRLLPTTTHFEMHPALSLHKLVVNQRPEVWEGSEFILTCMAYGSPNMAFTWYKDSVKINFNGTTRDIWTRTVSEDALGRRMSVLGVTEAERLDSGKWSCAADDAGRRRCRALRLTVLRPPEIRLVPSTLTVNRGDNVTITCLAGAGRVHGALGFSWARERTLLPMAPGREVWEDLFPAGSVLKLYNVQKSSEFRCQVSSVAGTNAKAVTMWALGSGDAACESDASHGLRWPKTAPGAHATASCPPGHSGETTRFCEPKTGDHGVKWRLPDFSGCVADSLRDIYEQFTLISMGYSWGSVSHVSRQYGAVLRSLPTHPGEGEPPLTHAVHMLNYLMSPAAQPHDRYNSLRSSFNKRYHEFTVMTKPVLEDNAAHFDLQPALAEREEWSVTSAGVELVTKTENASVVTALYHDLGARLPSLKRFVEYKSGRATQYTIASQQIQLSVSGAGVDNTLLHTVTLLFTHSKNYSAIGPQLACGSRSRSSPRVWSTHTCELRVQEQTYIACRCRGLATIALFTVDSLGLTDAESDSRAIVKITVSLGSAMCLVAALLQLLSLVVGSKTRLPVLLRAATAATHSAAMLTLLECDTKQTSACVGPLGWAVAACWCAGCAALCAQPLLLHTELAATATRAPSVGLLAGVSTLCWLTARLWGGAPLQLGAAANAVCGAGAALLAALTLCLALCAARTLRTVTQKLPPDRREYVRERARVVRHTLVLLFTTTATHIAGVAYAQPGERTIPKVVALSVAASANGLAMLICYVICDEECLRAARRLLTLSSNNDWQDSPEGDTSLSCKFLKIYTFARNQCDYKISFSMIVDVVVYIRQGREMECRGAVGSLECSSSHVSPANTYWRATPLQSPLHRRGSSGACVADIVRCVDICFDKRCIISLSVGGAEPRVSRVCVELGVLLEASQTTVTDASTFQPSSDTSDISKANCTLCAKSTPDVSATSTAPRPIKSCLKKRSPQLSWSTSLPSINHESDESNSHLQLVDTQSQTPSTHTTFTQTDKVLHKISHDLDFLLNRTPSRVADNCPQQIEEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Q4</accession>
    <name>A0A835G8Q4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Q4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF185">
        <property type="entry name" value="NEUROCALCIN HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="345" mass="38110" checksum="88F95A720CA2A037" modified="2021-09-29" version="1" fragment="single">EECEESIFPTGVVRHRPEPPGTLAQSTRFTAHEIKLMYRGFKQECPSGVVDEEAFKNIFCQFFPLGDATQYAHYVFKTIKHKQSGKVNFEEFLDILSRVARGSVQEKLSWVFTLYDVDGDGRISRSEMLAVVQAIYELLGRAAAPPVHSTAAKDHVDRIFHLMDTNCDGVVTPDELAHWCSRDPALLSSLHTMDTVLSDSARASCSTAADNCSPSPSGIPTPFAPPQQIDRDRTSIESYAPQLHQKRDTMESFASVETHGERDRSIVETESESGIDSGAASSSTSGVKSVVSSGIGSEKVTEKREEKKKQPPPVPARVTACITEETVTRKVKRRPRRSSSPQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G915</accession>
    <name>A0A835G915_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_004759</name>
        <name evidence="9" type="ORF">HW555_011169</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000316">
        <property type="protein sequence ID" value="KAF9409473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000579">
        <property type="protein sequence ID" value="KAH9634986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G915"/>
    <dbReference type="OrthoDB" id="6138780at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001749">
        <property type="entry name" value="Neural/ectodermal development factor IMP-L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032293679" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9634986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="262" mass="28797" checksum="B7A15FD2E74D8FE0" modified="2021-09-29" version="1">MMNSLSLLAAVFVSLLCTFASAHVADSRKGLDNNIQPNAATPKRKHLKDMVRIRNAPPETVQLEPGARLVLQCDVFGKPAPSVQWLKNGEPILDYEVESNDILPAHPSSLALLTSKLVVSSSANGDVYTCVATSALNQKTASTTVFTVDGNDEENLLTLEKLFRMPTKPVITTFYTNVFQDIGSELILPCRVESNSQSQIFWQDQNNELIFGNSRMRVLPSGDLVISPLLWSDMGNYSCIAKNVYGKDTVDTFVYPLKPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G916</accession>
    <name>A0A835G916_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G916"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="128"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="764" mass="84493" checksum="B66DC8F4A1CDCA63" modified="2021-09-29" version="1">MLFAVPPTMADTDTEPLANGTGPLSTEEEDERLKQRPADIDADVREMERRKRVEALMSSKLFREELERVLDQQMHEGNDAPLLQRIREMVGGRLHTGSMRGPACVLPINDIRGIEGVGYEKGEKILRCKLAAVYRLVDLFGWTQTGNHGQITARLNTAVESVLTTPRGLLPHEVTASSLVKVDMQGAVQDQGTTNFPVNVDGFSVHACVHAARPDVRCVLHVRAPAALAVSSTRRGLLPLSHEAALLGDVAYHSVPPGVLDNAEKDKLVRALGPHAKLLVLSGAGALCCGATLEEAFHHARNLAAACEVQLRLASLPLDELTLLDEDTRRQIYEASRKPPSDSSKWRVGGEEFEALMRMLDNAGFRTGYIYRHPLIKNDVPRPKNDVEVPPAVSSLGYLLEEEELYKQGLWKKGQGKTGERTRWLNSPNVYQKVEVLETGTSDPKKITKWVDANNEEWVQDGSPAHSSTPVKIDTLQFVPKNTNPKEFKALQQQIKENRRADKISAGPQSHILEGVTWDEASKLIGEDAVNTHTGDHVQVLMGAASKGIIQRGYQHNAAVYSAPYARNPFDHVTDTDIDEYRRTVERKQRSDYDTDLSESEAISAAQITSPASAPSETEEESRDEHRVLRIETKQAPVRSQPEVVLSDECLHVYVDVKIPYPLLVDTTDFLAAERAHADRTKDPPRDPNLLSDDEVFYDSPVPPASSPEQRVVIRAAARQPTVLSDDEVFTSPPKPVVVRSQHYTTPQPVPTQPSQPSQPAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9L7</accession>
    <name>A0A835G9L7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000317">
        <property type="protein sequence ID" value="KAF9409464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9L7"/>
    <dbReference type="OrthoDB" id="7110615at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="309" mass="36215" checksum="D1F537F7AD9D0F10" modified="2021-09-29" version="1">MSMDEMHPMFPYTKEDVQEIRKELGLKESTIEGDIDAIVDWFQKQPHLAEAGIERAFVERMLIVAKGSMEKAKRRIDNYYRYRLLAPEIIQNREKVLSDSQDLWSSYLQLSMPKMYKCNRVSVFQLLNPDPSAFSCEAFLRNTFMLGDVRMKHDYFLGDIWIVDMRHATFSHLLRMNPTLMQKAAHLFHEGLGLRIHSIHVLNANSLLQHVVSFMRQFFSPKIIDRVIVHESLDALHMSLPKRYLPKDYGGDEPALAEFKDKYEKEIRSTVTKQFLINSMKMVSDEKKRPNADINEEYLAGSFRKLDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9M3</accession>
    <name>A0A835G9M3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000189">
        <property type="protein sequence ID" value="KAF9412439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9M3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="75" mass="8510" checksum="D739E9EAF8D9868F" modified="2021-09-29" version="1">MSVVTSFMNDYNNATGASRSRTYCNKRSTLLSKVLQKAFRSLISDEPTKHVIRKHAKAVTKPPERLHKVHTTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W3</accession>
    <name>A0A835G9W3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000305">
        <property type="protein sequence ID" value="KAF9409649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="12741" checksum="CA9FB1933CD63600" modified="2021-09-29" version="1">MELSVMKLSARHLNYNPCLTLQARLAESASCAGEGSAWVSIGGVVTRVLCGSMELKAEAGMEGALVPRPVKERKKHDRFNGMSEEEVSRRTLPDHLAENLDIIIVSMIAVSLSLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W5</accession>
    <name>A0A835G9W5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly(A) polymerase RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000291">
        <property type="protein sequence ID" value="KAF9409881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="5">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="16998" checksum="136134C2C80F3115" modified="2021-09-29" version="1">MCMNTSIALAHVNTECFNSAPLNATTGQPPAHCCSMWFIELQFEKSTLNLDLTYDIQTFVENVNSQARKSYMLREGMITQARYVRRKQLNQYLPASLLRRERTSPDTNSSSLSTPSPPPVPSPPPVSLDATERLPGRKQTVLPNTTIKTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA47</accession>
    <name>A0A835GA47_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_000624</name>
        <name evidence="2" type="ORF">HW555_008990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000599">
        <property type="protein sequence ID" value="KAH9634652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA47"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9634652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="28512" checksum="19FE636CD2CA0B83" modified="2021-09-29" version="1">MTDSSSFTSLFALVDSHLSKCNLNDTPSEDGRVGSLPMPMLNLPRGLSDTGLSNPPPRLPIPTFTLSESPIANVLSEQLSNMFKAKELKKQQELEQEKLQEEMRRMALEEKNCVIDLMKAVQKPQLPDLKPKEEPSSINSSFESLVLDYKEFVANSPRRTSEVGLPTPEPEPLLPIKTDMSYILKQKIKRGKCSAFGKVLTSRLRPVAAPYLREKVPTNIVRFDFSTKSPCDLIKEKLKRKPVHTTSNSYDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA54</accession>
    <name>A0A835GA54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA54"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="6">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71204" checksum="D5F7A4BA2977D818" modified="2021-09-29" version="1">MYICTQSLYMAVIFGNRPAYMRQKRIQANSYFCQYSGKTELPTWRRRGGDVTTATRHRANNDLLGNRTKGLQSVSQTQLVFEQSERGGLLLLRGGYQHNKKRENKNGTTVWCCVKWQTRKCRGRVVTKNNLVVSDDPHTCQPNFAANIIKKQLNQCRKLAATKSDPIPTLFNNEMSSLADFGLDLVATIPKFTSIKNSLYHSRNKALGVKRTTFQTASAVEIPDAYKDKILLADYTDQRNRIIVFGTHNAKHLLATVEHIFADGTFKICPKPFYQLYTIHGDLGSSEETSNVVPLVYALLLNKKQATYEILFQIIKSQVPDWNPKKFQSDYEAAAMNAMQKIMPNCKISRRVSDTHICKYQSYGSTQLTEAAARQLNTARRSTTQLDITSTLTLRRHSFRGIIVPPLQQLVTQLAQIENFKVNEGRDSRLPDTVRQLAGHAALVRLQQEPLLRVHDRHTLRQQSSLAVHQHGVELAHRQQAPVVSDEARAAAPALEHLGSFSVREHRPLGPHRQEYERILVAHMQVLADEGDLGGGAQRVPDELIHRHVEHRHEQRLVQLGHLSPAHGADIVHSCTSPGAARRHASASRRSPPLAGTPLSLDTPRHPLVYNAHKHATGGKTLLTPLSQQQTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAB6</accession>
    <name>A0A835GAB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000297">
        <property type="protein sequence ID" value="KAF9409812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAB6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="28810" checksum="16BE5DB021B31C1A" modified="2021-09-29" version="1">MEKCGVCSENLSEGAHCATCEQWFHYQCAGVTKSGYQRLSKDKKLNWRCVKCKPSETAHPPNSPRPDSESDLTGTEAVLTEIRALSAKFAPLEGLKEEVLALKKEFLDFKSSMNTQFSDVVNEFRSKINEMEQRIVLMDKVQCQVDQLQERINQLEEGSNRNEQWLRMNNIELKGVPQSNNENLIDIVAKIGARINYPVSKNLINFISRVPSQQKEHFKPIIVGFCNRYIKEDFIAAARYELKTSPLTGKGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAD1</accession>
    <name>A0A835GAD1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000180">
        <property type="protein sequence ID" value="KAF9412706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12783" checksum="85DAF46C46F26459" modified="2021-09-29" version="1">MFQKHIFGFSFVNIVYVQTYLLGCTIAAIYGGQRLLNEGLKFQRIISKLTNTLTTDAPSPVADAVTKLQLFVKINPIRIEYTKKLVLKMHLVPIILSLSATYIITILQFTHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAV0</accession>
    <name>A0A835GAV0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="63" mass="7384" checksum="0DEFBB11D334BDF1" modified="2021-09-29" version="1" fragment="single">MFSLNLSTGNQKKLCKNILRVHCTSFRKMSVCGLFYMDICHPLRLVVLLLNYIFVLLQFAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB84</accession>
    <name>A0A835GB84_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000160">
        <property type="protein sequence ID" value="KAF9413417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB84"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="35179" checksum="2D30D8D2DE8C63CF" modified="2021-09-29" version="1" fragment="single">VVSIATVFVNKTLLSSQEVALEAPLFITWFQCIVSFSICYSLSRTGGIPGVFTFPKGTPWNWDVMKRVIPLSLMFTLMIATNNLCLKYVGVPFYYIGRSLTTVFNVVFSWVLLGQRTSYRCIFCCALIIFGFYLGVDQENLLGSFSLIGTVYGVIGSLMLSLYSIYTKKVLPSVNQEVWLLSYYNNAYSIFLFLPLIIINGEVSVLMSYTNFTSGYFWIQMVIGGLCGFAIGYFTSLQIKVTSPLTHNISGTAKACAQTVLATQWYNETKNVLWWTSNIIVLFSSALYARFKQQEMEENSRKPVPEEKQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBH2</accession>
    <name>A0A835GBH2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="313" mass="36344" checksum="FC34209F88047163" modified="2021-09-29" version="1">MARKKEESLALRRANHARVEGTRASHSLSFEEPEGDRGADESTTADDSALADDSTVAVGNRIPDDSAVTDVADNTATDDSTADANSHSCIICGKYRMYVKRRAVCLIKATNTFIEFMKAVSTKYNNIEMLRTIETDDNRDDNCFYHKHCKTKFEWHCKNNLETKNEKTWHKKRQCHTDAYDKICILIRERVVKNNECLFYNFISEKYIEFLHEQFDNVSNVEKPDFFSSRHLEKKLLVTFNTEIKIIFSDNKKYIAPYAGHIVSNQEYFKNIETRQAIYNIGQIIRREIINMDKTKLPEDISVQDLIRDVEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBZ5</accession>
    <name>A0A835GBZ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_000626</name>
        <name evidence="7" type="ORF">HW555_008992</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000599">
        <property type="protein sequence ID" value="KAH9634654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBZ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9634654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="553" mass="64447" checksum="D148D8868D0CE20C" modified="2021-09-29" version="1">METLSRISSTFESVRSNIKNRNSSERLQNLKKDIQTLTNELIVLGKENHDQYIRSLAMEGYLALLSAKTMPLSYVEKKNILQTSFEKLKQYALREECLFIMLRIQNLLCYYMIQLDQIADAREILENMEDLYDQISKSEPDKFLDAEDLFTVEPVSNIKRVNPEKIDKVITNNVQMQAFLYNKMNLPHKYTLYNHTALRRQLEMKEGTPQDWALRTARLGNYFTYLNQIGNARHHLCAAYHVLRTCHDNCKLMPEEFVLQKADFEIHFLELSHHWVKYGLTLFKMSKKKILNKYFTQPSTGADLWKTVDLLEDRLHSSEKLDEENMKDLGAEKSGKGDCTPEKLFTFPSLDLKEMEGKVPLESVCSVEDARKLFAFTYKWLMRAKHYYDFEHHSAQYISCSLQLAELYEHLAFFERNIDNQYSIQKRRANVLETLNSLLKTCDNVMSVQIDVIRELSQVQLELMALNLQKLWREESHTNIFNMDTDADSIINSLDSESNKTLTEKTLNTSSKNMFLRKMEAATSINGKLFRLSGQLVARTPSQLSFSTGILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC75</accession>
    <name>A0A835GC75_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_010521</name>
        <name evidence="7" type="ORF">HW555_008872</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000207">
        <property type="protein sequence ID" value="KAH9642009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9642009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="15630" checksum="6A41B1C692233C38" modified="2021-09-29" version="1">MFIRKPYQLFLATSLRALNYATKSPKPEIPQNPLASVYSATNQKDNGVVYDKKPFKLTLEAGKTYHWCLCGRSKSQPLCDGTHKDVYLKITQRPVRFTVEKTKDYWLCNCKQTKNRPFCDGAHKQKDVQEAGSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCV0</accession>
    <name>A0A835GCV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cystinosin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_009531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. May play a role in the degradation of engulfed apoptotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cystinosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000214">
        <property type="protein sequence ID" value="KAF9411740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCV0"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000023">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032784021" description="Cystinosin homolog" evidence="16">
        <location>
            <begin position="40"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9411740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="430" mass="48482" checksum="F2537FDC02DA1312" modified="2021-09-29" version="1">MAGVATVLKPRGVACASSSHRLSLCFVFVLLLGIPSAHSQLEKLYVSETDLNILVDDTHLMKLIQIGQYNESLQVTANIQHPDIVQFVPQTIDIPGSKEPNTTVKITYDICAYAKSPGHSEVTFNVTPAGYVNMDSVFLRITVMHSHAINVISYIMGWIYFAAWSVSFYPQIYINFKRKSVVGLNFDFLALNIMGFTMYSLFNCGLYFSKEIQSEYFARHPRGLNPVQLNDVFFSLHAAFATLITITQCFIYEREDQRVSTTGRSILGVFTAVVIVAAGVGAAGKLAWLDFLYYCSYIKLSITLIKYVPQAYMNYKRKSTVGWSIGNIFLDFVGGSLSILQMALNAYNYNDWISFFGDATKFGLGLFSLVFDIFFILQHYVFYREGKEFVRVNSSDEGSELSSSSEGREFFVLVDDWHADEKKYDLDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCZ5</accession>
    <name>A0A835GCZ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000194">
        <property type="protein sequence ID" value="KAF9412272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCZ5"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="114"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31478" checksum="BD376B9560DEA19E" modified="2021-09-29" version="1">MGLATVIENEAHFQTEMANAGTKLVVVDFTATWCPPCQRIAPFFEQLPAKFPRAVFLKVDVSRCADTATAQGISAMPTFIFYRNRTKIDQLQGADPTSLENKVRQYYGTDEAGDDDNTVAGHMDLATFITKSECECLNEADNHPMAHCLTSAGGYLASDCDEQLIINISFNQLVKLHSLKIKGPSDKGPKNVKIFINQPRTLDFDQASGNMSVQDLEFSPSDLEGNPVPLKFVKFQSVQNIQLFIKDNQSGGDVTQIDHLAFYGSPISTTNMGEFKRVAGKKGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD65</accession>
    <name>A0A835GD65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_009084</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="84"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9412415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="554" mass="62213" checksum="91FD7DD76CDB6647" modified="2021-09-29" version="1" fragment="single">IRDDLTNAPDRQSFANHGLKRTQYHSFIYRVVSFNTSVNNNNCRNMASLRSGSGVQVVTPREDHTFLLDEEALQNLLLRADVKDRPVVLLSVAGAYRKGKSFLLDFFLRYLDHTYNNGDGGGEWLGTETESLKGFSWRGGSDRHTTGIHLWSQPFKAVTASGEKVVILLMDTQGTFDSNSTVKDNATVFALSTMLSSVLIYNLSQNIEEDDLQHLQLFMEYGRVALDETGGKPFQRLQFLVRDWSFAYDHPYGSVGGEQLLKKRLLVRETQHEELQKVRQDIARCFEEVTCFLLPHPGLKVSTDPEFTGKLSDIDPEFKSCLKKLVPMLLAPENLVPKQIGGQKVKARDLLNYFKSYVDVFNSEELPNPMTILQATAEANNTSASSEARNVYETLMEEICGGTKPYMPQNVLEQEHHKCLNKALHSFDSKKKMGGEEMATKFKQLLVKDLEDLFDQLKAHNESKNVYRMFSTPAVFAALFLCGYLLSVLGNTFGVQTLVAVGQAVTLGAAVMLGVWIYTRMTGNLREVGMQLDDIANKIRSFVVTQAEPALKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDI6</accession>
    <name>A0A835GDI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box/SPRY domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_016518</name>
        <name evidence="12" type="ORF">HW555_007212</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of an E3 ubiquitin ligase complex composed of hiw and Fsn.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FBXO45/Fsn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000582">
        <property type="protein sequence ID" value="KAH9634957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDI6"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051961">
        <property type="term" value="P:negative regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060386">
        <property type="term" value="P:synapse assembly involved in innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12907">
        <property type="entry name" value="SPRY_Fbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000055">
        <property type="entry name" value="F-box/SPRY domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000017">
        <property type="entry name" value="F-box/SPRY domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035784">
        <property type="entry name" value="SPRY_FBXO45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF7">
        <property type="entry name" value="F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="10">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9415056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9634957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="266" mass="30357" checksum="F1641EC0383F01FA" modified="2021-09-29" version="1">MLIMNEFDFYDDYAVAVVVCTDNILENIFSYLRLKDLRNCALVCKTWYRVLNDENNDVWRLHCVKRLAEEVLKSDLLSTVSTYKSKLRAYFHAWNPHDCSRNIYVKANGFTLHRNPVAQSTDACRGKIGFYHGRHAWEVIWEGPLGTVAVVGISTKDAPLECHGYVGLLGSDEQSWGWNLVDNHLLHNGDTQGHYPLLNNCPKYQVGERIRVILDCEDNTLSFERNYEFLGVAFRGLPNKKLYPTVSAVYGNTEVSMIYLGPPVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE49</accession>
    <name>A0A835GE49_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_000507</name>
        <name evidence="8" type="ORF">HW555_008900</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000278">
        <property type="protein sequence ID" value="KAH9640563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE49"/>
    <dbReference type="OrthoDB" id="7354477at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9640563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="267" mass="30013" checksum="175F117BBC33A133" modified="2021-09-29" version="1">MSDNNAQSRLVSYEQVKSIIDFMAQHVEFASGSLRSLEARHTSKRLWEELAKILNSCRGGTRKTTDGWSKYWSDFKNKLKNKVWLLKRKKAGNSLKGIRPLTKLEKRALAILGPYYEKKKSRDADSQMNNMHPKVKLESIHETVHVNSFSKSNNGNTLSGGEDESDDSAESYDGEYTNDNDPNVPALQSIYPKWLIEVEKKRADAELIRAKAEEQRAVVAAKTAEASLLQAEALRRLADAATSQAEAIMRIAGVLESRAQRNSMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE95</accession>
    <name>A0A835GE95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="427" mass="49376" checksum="CD7A8A981460AA97" modified="2021-09-29" version="1">MNRPPRPQILNNFHRGPIPYQNQWRPRGPPRLPWNNSRFGQTFVKTENQNSDEHWCETCDRGFPTEDILQKHKQQHQKCNIDGCQFVAHPKVITKHIQMQHSTGLYKKIANLNNPEEIQKWREERKKKYPTKSNIEKKEAEHQEKIARGEKMNLNHDHRNYRKTLGSGYGTKRKLGDDKRNQTKPGVNRGTKQNSSNKPNTSISTSTEVLDPPKKIQKKIPAAPATIEKNKLKPFVGILSIQMEDNTEEVPDTTENSNELFDDDYDENTEISKEITNKEPVLCGALSSLMCDYGSSDEENETVNKLIVPDQKQLESSIEIKINPTAVAPTIEKIDTEDDDAPEEVKIEKSNTEHDAIEITTKNKEKRVVKSVIPRKNIDKPNYKTKRKVPSTLLQKLLHSEIRQERNIVLQCIRYIKKNNYFVKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEA0</accession>
    <name>A0A835GEA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_000435</name>
        <name evidence="8" type="ORF">HW555_007806</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000052">
        <property type="protein sequence ID" value="KAH9645272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000002">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9645272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="9559" checksum="867A58F39B90DE4C" modified="2021-09-29" version="1">MGRRKSKRKPPPKRKAIEPLDQQFNCPFCNHEKSCEVKMDRARNTARIQCRVCLEDFQTTTNVLSEPIDVYNDWVDACESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEJ0</accession>
    <name>A0A835GEJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_007612</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9414538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="58853" checksum="591CFE09305FBC54" modified="2021-09-29" version="1">MIIYLLWLVCFVLVAIPLYFRWCHAGRLMAKIPGPPELPVLGNFVTLYRTQEDLFTDTRLYNKTYGRIWKMQALNLRSVTIAHPNDIEMILSSTAYNEKNLPYTFLYTWLREGLLVSKGEKWHQRRKLLTPAFHFQILNEYFHTFRQRTQDLLLDIENDKDKEQVDLKPVFTKATLHVMCETSFGTKVEDTPAFDKYLKSIHDMGKCLIYRLTRPWLLDETLYKWSFNAKKEKSIVKELHNFTKQIVEKRRQKRIFNSNSPIIENLLEKKTKPALLDILLDEEEQGNIDNDGVLEEVDTFLFEGHDTTAAALTFMVMRIANESVVQERIYEELKDIYGGSQKQLKLEVEDLRKMRYLECCIKESLRLYPSVPFLSRYIKQEVDIGGYTIPKKTFCNVNVFDLHRSPDLYPDPEKFIPERFLPENVVTRSPYSYIPFSAGPRNCIGQKFAMMELKTVMSELLWKYQLIPITKPEDLVFTADLVLRTNHPIFVQFRPRMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEJ8</accession>
    <name>A0A835GEJ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEJ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="437"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="891" mass="102634" checksum="0F0A89DF10E17C64" modified="2021-09-29" version="1">MSAEPVEYLETEEVYMQLNQNEIMETEPADDIDDHWEHNSIKMLLNLYLQNVDKFRSPKVKKKNVWIDIANAVGKGPDCCDKKFRNLKQTYIRLLKKRNRNEVVVVKWPYFEVFEKIYNVNGEYQPEIQQRIQEASTESVTKALLSIAEPSTYEQDVQENGESSNGQSEESKRKLNRRRYADFRKITLEMRNRQRTVEEKSWSLRSFDKDGGVDVLVCLEDLCSEENLYVKFVETDNTFLESLGEIKHRYSLGLRCDFRSSKSNLSKSKEKLSPDGAEEKLLPKEVEAKIVTRVDMADAKYVVEDHRNGDAKIELDANKRLGVPNRVHVMQLQQPERISRNNLKMSQTLRAEVSSYLFFYNRIFYNCSLLADGEESVDDQDTAQFSGLTKEELLKYADDPFWVNLRWAMFILFWALWLAMLAGAITIIVKAPKYLKGLLVDMEESPYAEIEDDLQLLEHFKVQGVFVDVPTYEIIDENPSVLESFKRFVSMAKSHGIKTRVIVDLIPNYVPLSHMWFRMSENKTDGYDNYFVWKEGNFFDESGRRVPPNNWVSTLNQSAWTWSEQRKAYYLHQYDVSQPDLNFHNEEVVKEFDNVLKQWMKAGAAGVRLNKVRQLLVNTELKDEQPLTGRGSDLAADHTYYSYWRHTQTTDQPKLMELLQRWAKVVDDASEAPGTGSSVFTLNEEGGRAELFLLHKNITYLRPLVSKPLTIQEDVSATAAEINERIAKWPALNLRTFPDTQQELVAFELLLPASPILNPHQLEKEDNETTTSESLAHFVSMRDDASIQHGHYVVAAVPARNSSTNTLLAVARWKTGHTGYVALFNPLEEDQRANLTAVSSIPDTLTPHFMSHAVRQYTNYSLHNAEPADNLLVPPKSSVVFSYVPRTSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEM7</accession>
    <name>A0A835GEM7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase N2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_003762</name>
        <name evidence="4" type="ORF">HW555_007225</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000093">
        <property type="protein sequence ID" value="KAH9644263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEM7"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003045">
        <property type="entry name" value="GD10885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9644263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53365" checksum="B0D0F3372A4DCB22" modified="2021-09-29" version="1">MNKMFAPNSCFHVSSLVKYHWKRCYQCMKLLSSQAQENPVATDGPWSVYSQRVNSGVLSKDSHQEEVVQHLQQVYEQVVAFERPVLHSSSAGSLFSFFRRPQPQKIIAPKGLYIYGSVGGGKTMLMDLFYDTVPIKEKLRVHFNSFMLNIHARIHELKIKSGKGASSFRDEGSKPFDPIPPVAADITQESWLICFDEFQVTDIGDAMILKRLFTQLFDNGCVVIATSNRKPDDLYKNGLQRSNFLPFIPVLKSHCNLVQLDSGVDYRLRGTGNKYSKYFLNSELTPENNAVDNLFKFLISKENDTVRPRVINIMGRNVKFAKSCGRILDSTFEELCDRPLGASDYLVISKTFHTVFIRNLPQLSITTLRSQLRRFITLIDTLYDNRVRVVIAADCEPKDLFKADEKTEFADADRALMDDLSITKDSDDANAAIFTGEEEMFACDRSLSRIMEMQTEEYWDKWGKHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF60</accession>
    <name>A0A835GF60_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000147">
        <property type="protein sequence ID" value="KAF9413922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032891340" evidence="3">
        <location>
            <begin position="26"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="6">
        <location>
            <begin position="88"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="4">
        <location>
            <begin position="339"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="5">
        <location>
            <begin position="600"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="5">
        <location>
            <begin position="1546"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1902"/>
            <end position="2494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2517" mass="280561" checksum="2D151CF92DE5E10A" modified="2021-09-29" version="1">MVWCKFKWKCIVFTYIILFNDLTTSIPTNKTSIPNSNIKLDNLETNFAKSAEDIFANSSDKLYGNNNVPANATHSALIKNIRPGQTVHSLHVKITVEGNLFKGQVEMSVQLTAETTEDPIVLHAENLNINSVKAAVLGGTDNMNDANFDVDDGQLTILSESKASAYNIRIEYTGQLSNIGRGLYLGGSKENTYVAMNLHPTYARRVFPCMDEPTAESIISFSFEGLDYTHLISNSMLEENSQTEFRALEGPPHLWGMMAHNFVTVNLPTVNVLLYSRPGISNQDSQASVAINSYFSNLNEWTQKPYFEIINNQNGRMNIMVLPDVSTDWNSLSIVGIWEPYVFMDPGHTVKQRAIALTKIAEAMARQWFGYVIYPENWKYEWIVAGFTTYSAYEMMRLFQGDNIADPNLLDVNTLFVTEVIQESLLRDAYINSKPLEPADNIFDEDAIRDHVNGLIKIKSAAIMRMTRLVLGDANKDFIQKAARALLKGQSLKTVNTFKFIDGIYSELLGNGNDSPIEYFEEYLEPWIQNNGYPLLRVTRTSTGVLLHQTPFGFTKRDSLNRPLPITYTTSMERNFDNIYPQFMLDGSHNLNLLLDDEDWILFNIQGQGYYRVTYDTELWESIIKALEDPKRRNEIHPLNRATLVDDALNLARAGELSYDVAFSVVLSMEHETEYAVWKAFVRNMNFLRKRLEAYVLDDADLDPNVYMVKLSFNPDTSLAEASMTSLTRGLVMDHACRAGYKPCVTAAVDFFYDPNDNEVVNPNIHREIKPAVYCTMVREGGEEVIQALYNRLEIEPTHYERVVILESLGCSNDPDFINELLMQTIAANSPYGVEERVKIFAAVAESSYTNADLALNFMKLRVIEIRNMYGGPEKLEELLFILAENMADKELSEEFVTWVHSVSNNLDDSQMAAERALAYVNENLKWEDQYMDDTFWKLSEGPFKLHQYVLVQVKVEVYIILLNDLTDSLPANKKSTLLNSDIELENVRTDYTSKLAEDLFENNGDKLDGNKNVAVNASQSTLYRNIRPGQTVRSYAVEITVDGNSFKGQAVLDVMLSPATREDSIILHAEDLNINSVKAGVLGGSNINEAVFSYNRRTLEIHPITPAASLYSIIIEYTGQLSNTGYGLYLGGSHQNTYVAMNLHPTYARRVFPCMDEPTEESIISFSFKGLDYTHLISNSMLVQNSQTDFRPLSGPPHLWGMVAHNFVNINTPTANVMLFSRRGLFNQVSQASIAINFYFNHLNEWTQKPYFEVVSDQNGRMNIIVLPDVSTDWNSLSSVGIWEPYVFMEQAHAVKQRAVALRKIAEAMARQWFGYVIYPENWRYEWVVAGFTTYSAYEMMREYHRDHIATDINFLDVNTLFVTEVIQESLLRDAYINSNPLETVDNLFDEDAIRDHINGLIKLKSAAIMRMTRLVLGNANKDFIQIAARSLLKMRALGTVNTLTFVDGINSELVGNNNGVINNFGAYLKPWVENAGYPVLRVIFITGRVWLVQIPFGFTHKEPSNYILPVTYTTSVEKNFEDIHSQLIVDGNQNLNLFLGEEDWILFNIQGQGYYRVNYDTVLWERIIKALEDPERRKEIHPLNRATLVDDALNLARAGHIDYETAFSIVLSMEHETEYAVWKAFVRNMNYLRKRLEAYVFGDEDLDRDIYLRMIRSTISAFEREITFYPDMSKREPLMTSLTRGLVMDHACRAGYQPCIAAAVDWFYDPNNNKVVNPNIPYDIRPAVYCTMVREGGEEVIQALNNRLEIEPTHYERVVILESLGCSNDPDFINGLLMQTIAANSPYVVEERVKIFAAVAESSYTNAHLALNFMKLRVNDIRNMYGVKNLEQSIFVLAENMADSDLTRQFGIWVNSPDNGLGNSQMAAERAVAYVHENLQWGEQNINYVYESISHVDPEDYVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVEPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPIDPVEPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPIDPVEPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPIDPVDPVDPVDPVDPVDPVDPVDPVDPVDPVDPAEPAENHTSKLVSSLISLCIPIMAALLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFD6</accession>
    <name>A0A835GFD6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteoglycan 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000140">
        <property type="protein sequence ID" value="KAF9414175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFD6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41156">
        <property type="entry name" value="AGAP006184-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41156:SF1">
        <property type="entry name" value="ZASP-LIKE MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62780" checksum="757FB1F797100718" modified="2021-09-29" version="1">MTTKSYSKHKEFKEYSSSSGTIPYTDEQFDMIKSELIPKGSKLDSLGRGGGTREYHYEYKEEKHPSGKYDRKDLHTVEEYTIPPRTVPKSSESNSYYYEREERELPAISSGTRTYNYESSISSTPGYSKVKSSKVTKDLSQNVEELDSLLDDLQKDQERQLYKSKTLDGYTSDTAESTSFDYRKGTPAKAPSSGYSTLKREERVETSSWGSSPPPPTVTRAAEVRQEVYREEKTESRVVPSQVSPAVPQLVPAPVCAHCHHAPSTGTLPRGSTPMNKVTTTVKTYTYEVPADQDPTTVPIPVHAEHQHTYVSSEQNRTTTSAGSPPPPVALVSPAGPGGCQYCSHCNSTIREYRTVTTTDDRTNERMGPSSYKFSETTYSAHNTTHRYPSPSPLPHPSHTLHPANSPSPGPFPRPSTPSPGTQQPPKKLDDLLADFPEARFPTQPDGVVRRNVHVTHESSTQSSTLNRDTRDTRDSAPSPPAKSPVVANSRNVAGPAVYYPPGHTPFQKKEGGGGGGGGYQASSAMAQGGGSYASARGMYEYESGSRSKSKHSETKTAVPICLPLCCAMPCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFL2</accession>
    <name>A0A835GFL2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFL2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="347" mass="38887" checksum="6C7D1CDEDA87AD09" modified="2021-09-29" version="1">MDSDTFFLELPKVELHAHLNGSLSQATMLQLKRFHADSGLEDKTNAFFDEFQIGAGDTRNLTDCFQVFNIAHSLTSTPEALTIATRLTLQEFQDDGCCYLELRSTPKETPHMTKVQYIETLVKAIQKSSLHLTMITRLIVSINRKSSITEAEEIAKLTVEYYKKHPDVIVGIELSGDPMAGTFQSFVPALTQARNAGLKVTLHCGEVCNPVEVMEMLKFKPDRLGHGTCIHPKYGGTEETWETLCKLKIPVEVCLTSNVNTKSTPDYESHHFKVFYDAEIPTIICTDDKGVFSTSLSQEYQICVKTFSLTSSQTARLALNACQYVFADNVRKTLNDKLLNFIGKHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGG1</accession>
    <name>A0A835GGG1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGG1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45364" checksum="20CFEC7ECB14F563" modified="2021-09-29" version="1">MFDGSFINFLRMSKSDFEYLLQNVGPFIEKQDTNLRSAVTAETRLAITLRYLATGDSYSSLSYTFRVSKQLISRIIPEVCKNIIRVLKNYIQVRKTKRNKQSRALYTPPMTFDFEDSDHNVIEGAWRREYTVEGTSILELERRPSNSARTATIIRDQFGEYFMSERGSLPWQNNSFVEQSHNIRFFSNSSINLKTVSSSHTTAMFINKCLDASTLACTCCATDLLLCSPSQPELTDGAVSLAEKVEDGPGLLESLSDELLELLELDDDELESDEELEEEEEDNLLGITRGRDISLTALPVPDRWHSKYFNTCKYFCLVPGRRTLKQPLVLKPGMVYSFLRLKRVFTLFIFLLASMAAISFLIGGAFGNGLTDSGEKTLEVVARGVQALDVEATGSLALFIGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHP7</accession>
    <name>A0A835GHP7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHP7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="409" mass="46078" checksum="0F05AE46BA07A73D" modified="2021-09-29" version="1">MTQKEVKINKRKKCRKAKQVENEYESRGTRRRALLLSSDDVDRMAVESSRARLINHLVSKSDEHPHREYSSYYRRSSKYREPSFSVTSHVNREPFLKVPYVVPAYQSVVQSPRWCSLSHTMATSPQGSYTERMEIPPFVCKCANCTSAKCPGRKSNTCKTRKFKSNITTFCDQCTMTQNVHDVACGRTPIPSTPICSDAVPPCCSSMLAIISKHCKQMHGRNAMAPAPNRGCLYCMKNKAFCDIEPCRNQSVKCFFKKEQDECSDCPEIFSRKNIYNEGISDAVAGGFAPCARTVPTSPRCSSRTSISSSSTNSNIPHSHRNESKYHKHCVDPPERIFVQDNSSATTRGHYTDANPKLVARGSCGARACRHHAPVAHNIKMPKKVLTSERVLDHGTDRFPCHKTPCRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIS2</accession>
    <name>A0A835GIS2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIS2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032519861" description="AAA+ ATPase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="350" mass="39910" checksum="AB2A2FCFA7BAD6C4" modified="2021-09-29" version="1">MEIRNNILLFSILLTLLQCGYSEFITMSLLGSAAVAGLYHKWSTIKDNTYCRYVECCNDQHVPFDINKLKLTLTQKMFGQPLVDELVNILQAHKEAVNDPNKINKKALVISLHGWPGVGKNYAATMIAEALYAKGMHSKYVKLYMGKKDFDCSNLQQKKEDLVATLNSIVRKCPKSLIIFDEIHDMCPSVLDTIKPMLDHHHAVDGIDYRDSIFIFISNIGGQEIATKLLELYDQGAKRNDVEFHDFEPIIRRTAYFQGGFEKAAAIANHLIDHYVPFLPLEQQHVEMCALAEFRSHAIYHPTKEMMAEALSVITYGPNEDQPIFANNGCKRFTRHIPYVIQKNKQKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ72</accession>
    <name>A0A835GJ72_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ72"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="26310" checksum="9201878747BE8157" modified="2021-09-29" version="1">MLSCEQGNRWLRPVAHDHGTRSQFLSHRLYAFLNLSIEMCKLLALALTLCSVLVGTTDCTSSFDQRQTGDLNVQIGLKNINIIALLKGGKEEYVDYDYAYDYSEMTIKPQNGSTTPKPLNANTTISTTVLLEQTTEGIRNSTGVAVEVTEASLNQPANNNVVTTPQATADILTTIAPDSSNKANITTALPIPNKCRRGFVQNNEGKCEYKVHGTSNALRRIVKLAQKIKIGRQYEESQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJC9</accession>
    <name>A0A835GJC9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposable element P transposase-like RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJC9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="299" mass="33043" checksum="64C201EBD9FF0690" modified="2021-09-29" version="1">MRSPLTPPSTTSLQQLNLGHGPSPSSLTATMQEAALPSTSETNVHLNLGEKTTVKKAKSRVFLTNTEKYLQDKLVAASIKLSKMKNRFKKLSVNVKAAKQIASNPAAISYTFASSATKGPERAQQIKDVIRGLQESGFIVVATVCDQGPNNRQALKLLINENRGIYLRKGKNILPAECKDTADLLLFMDNIFDSVNGSRQKNRNAKPLLGPATPNSAHHQIWIEGVQIFKSMKFVSNGKKQSVPSITNWVWTLSRINKLQNEFNVSSVWLRHLNQDPLENFFGAKLKKGIPVLLDLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJG8</accession>
    <name>A0A835GJG8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJG8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="89" mass="10467" checksum="F6CAD4DAB1BD9DC2" modified="2021-09-29" version="1">MSTPVNIHYERERVQFRSALNTRVLRGKPRFVTPHGSRVLQAFRERNVLCEIMECKGASCMDSAERMLPTDTRRYTFAILEYTHKSYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKM3</accession>
    <name>A0A835GKM3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="146"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="279"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="357" mass="40394" checksum="88A1B1CA1E6FDE32" modified="2021-09-29" version="1">MPEVHPAFANAGKKAGIEVWRIEDFEPVPVPVSNYGKFYSGDSYIVLSTTGEEDRLAWDIHFWLGSKTSQDEAGSAAMLTVNMDDEQFHGAAIQHREVQGYESRQFLDYFPPAIRYLDGGHASGFNHVTINEGTEQRMFQIKGKRNVRVKQVDVKFESLNKGDCFILDVNHEIYLYVGENAKSVERLKAITVANQIRDQDHNGRASIEIIDADSRDSDFEKFFEALGSGDKDSVAEATEGGDDEKFNCQQEFERGADVEVSLSEISDSSGTIRITKLSPPFTQDLLNTKECYILDTGSRSGIYVWVGRQSNEKEKSEAMKKAEQYLKTHDYPFWVHVTRVPEGVEPTAFKQNFQDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM1</accession>
    <name>A0A835GLM1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="114"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="341"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="536"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="713"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="10">
        <location>
            <begin position="754"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="984"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1171"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1318" mass="143084" checksum="F42449363B91293A" modified="2021-09-29" version="1">MNSRSSEAVMVKSFKPTEVVYVSAVVDDVYSDHSHVAGSFTMLASSRAHVGGSLNARALPGARVHTNFIGCLKKVEFSADTLRLNLIDLARTGSKLITVTGRLEYACTATDSADPVTFTTRDAHLILPKWEAVKTGTISFKFRTNEPNGLVLFNMGAKPPRADLFAVEILNGYIYVHIDLGSGGVRVRASRRRVDDSHWHDFLLRRSGRDGRVTVDGANAEFKTPGESNQLELDGPLFVGGLGSEYSASRTPPALWTAALRQGFVGCIRDLVLNGKPQDLTAYARQQDSASVRPACHVLMKQCVSSPCQHGAPCSEGWNRPLCDCSMTSYGGPTCGRETPTIYLNGSQHLTAALGPEHITQTEELLLRFRTSRAGLLLRTASEHSADRIELAVAAGRVRASVRLGDREKNLLAGTNVADDNWHTVRFSRRASNLKLQVDGAQPVRAETILGKASTLEISTLHLGGLFHPEEEIQMTSTLPNFVGYLQKFVFNGIRYIDMAKTLGVGTNEETNNIYDTSNLIFTGKFVKPDSLNVYKSVTFKSKHTYVGLPLLKAYANTYLDFYFRTTEMDGLLFYNGGKKQDFIAVELVNGHIHCVFNLGDGVVTMKDKLKNFLNDNRWHTVSVRRPTPKIHTLQVDDDLEMHTTSSNLMLELDSVLYVGGVPKDMYTALPVGVLSRQGFEGCMSSLDLPGESPSLMEDAVVPSSSLGSGCEGPTKCTHNACANKGVCVQQWNTYVCDCDLTSFTGPTCYDESVAYEFGPGRGIITYTFPTDSVADTETDKVALGFVTSKADAVLLRIESSNTQDYMQMEIIRGNLFMVYNVGGGDHPLGDETARVDDGAYHVARFTRNGSRASLQLDNYAVIIRHPQGGQQSTIFNGMSTIALGGGAGGARSFSGVMAGVVVDGVRLLDLAAAGDVAVSLRGDARRAHAPLDRDINRMQQTPPSGYGGPGVLDELVYSGAGSGCRDDDEDACVLPDAGSGDDLITPVYVPSTRRPPSRLHKGDTSGKLMKPCDDEDCIEGSGSNVDEITEPDHPMTTSGASSTHSMTSPTAIIVSTEHVDKSLEGSTDGSTGSSETTKSSTVGQPTLPDHDNMHAGTVDTATPPERRTTPTDEHSHTRTSYHFTPTLTGKHIPDEPTHTTEEDTNHIPEYEDRRENEIEARTPTYETESEQDRIPGRVHPEYNGYDVTPKWYHPKTTDNRVVPPESEFFATIVGIVASVLIAIILIVIIVLKYIVFKFDPSYKVTEDKNYQQGASAALLGNQAHSSYQSGASSAPTGGAVRNLQPLPLNRNGTAPTAPLAPIPTQPVKRDGIKEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLN7</accession>
    <name>A0A835GLN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLN7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="8">
        <location>
            <begin position="560"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="672" mass="71713" checksum="F212D1BED7AE85A4" modified="2021-09-29" version="1">MPGARHKILGHVLSGFCHKMNRRKPIYGDSMDTPLNRCLTTLDITLLGVGHMVGAGIYVLTGTVARHMAGPATALSFLLAGITSTLAALCYAEFGTRIPRAGSAYAYTYVSIGEFWAFIIGWNIVLEYMIGAASVARAWSGYLDAILDGAISNATISITGEMHETLLSRYPDVLAFLICIVASLILAVGVKTSAYINNGLTILNLLVISLVIFLGFYYADIGNWSQKNGGFMPYGVSGVLAGAATCFYAFVGFDSISASSEEAKDPSRSIPIATILSMALVAFGYILVALALTLMVPYQTINPDAALPSALGAVHADWAKYAVAVGAVCGMTTTLLGSLFSLPRCLYAMSADGLLFGFFSDINNKSQIPIVNLIISGLSSALIALLFDLEKLVEFMSIGTLLAYTIVSAAVIILRYRPVPAVEDKSFGVPQLESPGDREDSSATGTPGTDGGSSSSEASIYFILTHITCRYMFEALTVGRLRAQYAWLEPLAGGRAPGAAVTSCVYTFTAAAAALCAHNHFLAEPAGLWALLPDFVLSFIIVACLVIIWAHQQSPTRLPFRVPWVPLLPALSVMLNVELMINLNALTWARFAIWMTFGLLLYFLYGIHHSKLGEGVTGLLSRSASGGGHSGGWGAVEKTSAIARRVGRFARGSKGDDRKPIISDDDLSRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLX5</accession>
    <name>A0A835GLX5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="203" mass="22593" checksum="FCD676BAC2D67808" modified="2021-09-29" version="1">MWNDQSAVGGGFFNSPNQFGNVNTPNQASKSARRSSRTAPIVIKQALHSGDDGVKIWGTEIQIVCIVARVRNIRMQSTKITYTLQDITGRMRAVLWLDQDAADDEEKVESNNSTFATGLPANSMVGVTENSGSVNGLNPRQMMVFNLIRASTMEQGISKEDMYGSLKDRMSQVEFENILEWMCGEGHIYSTIDEEHYRATDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN69</accession>
    <name>A0A835GN69_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN69"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="538"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="614"/>
            <end position="618"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="966" mass="112107" checksum="D720DFEBEAF97D2A" modified="2021-09-29" version="1">MNEPPVVNGPKESNKVLTSRNSTVKARTPEPRSPRLLPPIYGDAASSSGRTLPTYRPPKEEQSWSRFHSGCRQRHSIYLDWSSVKTEKKYTGSMPKRNKARSVTSFKDAEEQDVADYLNKNKDFLEAYVTERVPADIIQKWLQKKTRRNYITPSTFNHRQMMTFKKTEEFNKKEIFSDLLRVLKDDPNEHSVLWELANYITSSVGVDAHRVYKLYPDHPSFVQFFVVDLKPSRDVIRSLVRAYADQVHLVLEVAKSGVCRRVSRLDDAAKFPETPVTLFKSMGKNKQANHVMYQPILTKNGKTAYVIEMWRVKERFKEVDEEISSNFLVLGSLALHYCNLYLDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNFELVSTVFDLKFEPGHDRDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNREVDEATGYKTISILCMPIKVEGRVIGVVQMVNKRNDDNFGHEDEVSFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCKENEVTAMLSDKEPIKVDLDDFYLDPFRFNEFEKCKCVIKMFSVLFDLASFDISTLTRFVLTVKKNYRTVPYHNFDHGWTVAHSMYVILKNDYRKRFDYKMRLALFVACLCHDLDHRGYTNKYMSEIASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEVLGYIRHCILATDLAAFFPNLAKIKQLHEGDTPQFNWDLHSHRELAMAISMTAADLSASAKPWDIQIKTVKVIFEEFYDQGDKERAAGREPIPMMDRNKPDEQPSSQVGFLSQICVACYSMLYRILPNTRPMYAMALKNLERWKARAERIKRKQSKQEAEVESNTDEDSEPTGIVDKVEENVPKLKIKEEAVSVVDVMHESVSWEEDEEEIIENEIPKSGIWKDINGVTWIDEEGVVVRESVLKAIVNKENGEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPU0</accession>
    <name>A0A835GPU0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13203" checksum="735B51F25BFE2500" modified="2021-09-29" version="1">MKFFHFLHLKPDYAAAGLDSDEVTVAKAGDAGWYGARWPFVDTSSYFQWTGYSPGDNLLLPLLVAALSSIALVLLLALAVRRRKRSQIASSKLGLTADLQADDNTNLLTAENAEDGDGEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR52</accession>
    <name>A0A835GR52_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_010914</name>
        <name evidence="7" type="ORF">HW555_002143</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000446">
        <property type="protein sequence ID" value="KAH9637503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR52"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000184">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9637503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17022" checksum="66E671749AE9EDB5" modified="2021-09-29" version="1">MAAPQEARREPIQAVQVFGRKKTATAVAYCKRGHGVLRVNGRPLDLVEPRLLQYKLQEPILLLGKERFSGVDIRVTVKGGGHVAQVYAIRQAISKALIAFFQKYVDEASKKEIKDILVQYDRSLLVADPRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRF3</accession>
    <name>A0A835GRF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adiponectin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_000330</name>
        <name evidence="9" type="ORF">HW555_002129</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000078">
        <property type="protein sequence ID" value="KAH9644556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9644556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43629" checksum="39E41411E625AE07" modified="2021-09-29" version="1">MWESDSDTGSRSASSDGLRRRQGWDPEAESLASQMDELDEVLAEEEDGCPLPSTPEDQHLLDAEMAEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWNVCHFRHLPRWLQDNDYLHKGHRPPLPSFSACFASIFRIHTETGNIWTHLLGCVAFIGVAIYFLSRPSIEIQMQEKMIFGVFFIGAIVCLGFSFAYHTLYCHSEMVGKLFSKLDYCGIALLIMGSFVPWLYYSFYCHYRPKIIYLSVVVVLGMLSIIVSLWDRFSEPRLRPLRAGVFMGFGLSGIVPAIHYGITEGWFSQVSKASLGWLVLMGLLYILGAMFYALRVPERWFPGKCDIWFQSHQIFHVLVIVAAFVHYHGISELASYRVTVGECSMPPSSIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRF6</accession>
    <name>A0A835GRF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="41"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="503" mass="53322" checksum="C849D478FAF9F834" modified="2021-09-29" version="1">MDSGDRILVAAGLTAAVVVGAFVLWGPGGAPKVRKRRGQIAGLQNLGRTCFLNTLLQALAACPTFIEWLKKYAKADGHNSMITTLYTVIEVVNGTHESARGTPVCPLGVLQALRAAGWVVPADQQDAHELLHVLLSCIEEETTSMSKKPGCLSDALGLGGSRAWSALASPASPPAAPHPLRADSTPPTPSALSIRPASAAPADEPDLIESEPMMEPPRLTKGVSRSLCHLSSVGRRWVTPTVARPPPAPPFRGTLASRLQCTVCSHKSPIRYDKFDSISLSMANASIGVNGAYSLAGLLRAFTAPEMVKGVRCSKCCPDPAGPAGPADPAQPAPVGAYTKHIRTVSFGKLPYCLCLHIGRVEWLGGALNKRGEFVAFPETLNMAPYSAVQQPKQVDLMSLVGEGRLRAGLSALSAEGGAAGGEAAALYRLSAAVLHVGGPRSGHFATYRRGNGFEAKRWWYTSDTLVHEVSLQEVLRCAAYMLFYERVRPEPAMSASANSHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRI0</accession>
    <name>A0A835GRI0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RING finger protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRI0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="728" mass="81796" checksum="23998842E7A725CF" modified="2021-09-29" version="1" fragment="single">CPAQPFVWMLEESRMEKKSLNRTSQPQSRASAIDCKKNTESTQKPWPRSNKKREGPGSAPKNEPSRKYAPAQHGRGQFDRRPRPRGSTGYHVGGAQNTRLGGDEEPEIGSVFVPGSKKQNLNHLLNFTYPSRGVPEHRGHQVRRPGFQYRGPNRYGHDHYLRAYCQFVVNEDGDIKANLLDPDIPLKWEHIEEVVVRATGRSKCLICLGPPAAGRVYRCGHIYCWACILHYAATHDKQPPPCPMCSTPLHVNDMKPIRIVQWEPLAEEVTMRLVRRLRGSTSVEMAPPRGQVIEAMPAILPLENINNAPYTKMFSATKQQVLEILIRERHEIENQILAEIDTTEIVYLEQALEMLKSKEENINLRFSEPKVTLKEETDAAVPTVYEKQEENQNKLDWFDVNEDGAAACAEIMQGTTSDTGLADTNTNEKDGAPSKNLEWLDENEVGAACAADIIHNNMEALNLNTVDSNLNPEAPSFERDEMQPEEFPLTEGLVQETNQIEDNAVTNIDKLNHKKFFYFYQAEDGQQIFLHSLNVRILNASWGALAAAPQVIRGRVLHRETFSLTEQDRKHMPCTAHLPLFCAYDIVELELQPPFVTEAALNNFSGDLKRRAQVRARRKREEKLANRRAAEYQQRPDLSSFPPYSSSPPYSSPPLNSSPPLVPNLGEPSTSIGSPPSGMSFAQMAGNSGTWRERKTPVAPPPPPAAPALDEVSAPRMPMLMDFVLTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRP4</accession>
    <name>A0A835GRP4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_009143</name>
        <name evidence="11" type="ORF">HW555_002577</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000077">
        <property type="protein sequence ID" value="KAH9644568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRP4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9644568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13227" checksum="A361E553AA03C356" modified="2021-09-29" version="1">MGPLKKSTGLVGMAVAPNAHHTLGSLYGKILRVLQKMPESAGYRKHTEPLIRERAAVLTQTKDVYELESKINCGQAEELIIQAENELNLARKMLNWKPWEPLVSAPPKGQWDWPPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSF1</accession>
    <name>A0A835GSF1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSF1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7555" checksum="0184389D9471249E" modified="2021-09-29" version="1">MANSGRVVYPKEVAEATKKDDSAAKAEDKSSGGEEVVVVKRESPAFAMIQVPNNCPANKEMANDGVCREVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTT5</accession>
    <name>A0A835GTT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein Rab-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04113">
        <property type="entry name" value="Rab4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001193">
        <property type="entry name" value="Rab family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041819">
        <property type="entry name" value="Rab4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23629" checksum="8E770B723A9B721D" modified="2021-09-29" version="1">MSESYEYLFKFLVIGSAGTGKSSLLNNFIGNKFKEDRCHTIGVEFGSKIVNIGGKSTKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRDSFNALSNWLRDARTLASPNIVILLVGNKKDMEESREVTFTEASQFAQENELMFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGTGTSKRLSAPKKPARNPSDCACHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUQ1</accession>
    <name>A0A835GUQ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the hemolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="447"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="537"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="641"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="729"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="824"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="912"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168017" checksum="442C54B5C3D4D588" modified="2021-09-29" version="1">MGDLKNPMTLLDPGIEPNVEVTNQFDIKLFVKMLRRIFPLAVLLVFADVVMKASCTEKGSLTFVIDDTLSMTDDIDHVKRSVDRIMDIVFNEKASVISNMVLVTFNDPDAHVRTRTDKREEFNRALREVYVHNYHNYDCREPSMNGLILALNESNRGSHVYVFTDASAKDHKKAHIAKELCQKKQSQVSFVITGRCTVSYPDKMMSVYYEIAQACSGLAYEVNKNEVSEVLRPITDIISGEKVIITVTTVPAHIYKDIPFDVDDQTEYVIVSVSGKDVYLKLSGPTGRQENLMWNANGKLVDIKPGRYTATVKGESQTSVVIVGRSDFLFKHGFSELKPKTLNDTSLQPIANTNVHLSVLVSDERQTVEILKAQILGMDEKPIRQDLALTKISKGFYITPALITPTERFKVAVIGRVKATGRIIKRIAKIPITPQEPPIKLPDKQAPKAVISEGRETTVEYNSSLKLTCKVTAFPKPKISWYNQQGQLIASKSSMIEYPYDYISYLEMPVAKEDSYICVAVNEEGTKKVSIKVNVKDAFTVVNIRPSVNLEYGKPGTITCDIKSRLPMDIHWYFIDEMSGTKKEIANSNEYSITADKTQLRIKKVDLNSVGKYVCHAYLVNNRNVKKELSQRVEVTGLVPPKIQMHTNIKAIKGRPAVLECKVSGVPIPTIKWHFRGKPSSKFIPLAETGPVIRINNVEAKHGGQYKCVAENALAKDEKVTTLILQEMPKIVSSSSDGSSVYRSTEGDATLKIPCVAVGDPKPSITWKTDGRPIVVPSFKYEIEDGTLVIRDPKVTDTKSYDCVATNEAGSVSTTFKAFIQQKPEVQGVATKKVKLGMPVDIECRVVKGWPKPNIAWYVNNPGKQFVRIDGTTNVIHIAKAENKHTGRYMCLVQNEAGKTAHVTSLTVESQPEIVTKSKSVEAIEGDIAIKIPCEVVGVPQPAITWKRNGAIIMPNAKYSFDNGSLVIQNPNKIDVGNYICEAKNYLGSVSTTTELKLEKRPSTFGTQHFVYILYGKSKKIECEAYRSKSQSLKWFDNTEELHKKYIEIRDASVSNDGNYTCHVSDKQGHSETHTYIVNVGGPPKLLGDNPLNDWRGDVQELVSNCDSKAKPQAHVQWKYNGKEIPENDVHDLGIIYKWGHYTCNVSNPFGSVLKEFNVKSSVCLIPKNLKDAEYMPLALDKNGAWPTWESSKYFSVVEPEETITLSCPNHQNVPNSFKKIPKQTKLKAICYKEDVFLVEGNEYKLSDLQCIHGIQPTVAKKNVKCLAGNSELLKVGYNTGSFLESYEVCFDNSVRMPHYIRNTVTSKSDKVSSAIAWRTYPGIGNSLNEKAFTCKNKLSSCCYAKSQLVEAKDFRYAAEMNTTFIDPLNVVPVWRPCNASQTSWESINKMVREQTIYDEFVAWSGTHTWQRKNGAIVPRYLWKVLNFDEDEIFAIIYVNDRTPTNSDIKCENVCNNDDEPWFKFHLKMLSKVLHCGCYAVYILGPQSRLDNIITNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWF7</accession>
    <name>A0A835GWF7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWF7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="25056" checksum="F79CDB3A5DABA82A" modified="2021-09-29" version="1">MGHHISSMFSSLGRFFEYPVKRKPICFYRQEDFSATGEPHRKVADMQRQAATDYDKLVDLFYTRLAEQRQYNQEMKEKDRRWSMQKVVERFPGWNEVTIANLHSLFLLFDNQSNGMLGFDDFGAVLESLGDESGMDVRKDKFNAADTDNDGWITYDEFLSVREPSLLNAVHIGALVYNFNPSEEGRVTGLAAMCNDVAENIQFVSNLTVGEQLEYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWY7</accession>
    <name>A0A835GWY7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_002377</name>
        <name evidence="1" type="ORF">HW555_000249</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000528">
        <property type="protein sequence ID" value="KAH9635817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWY7"/>
    <dbReference type="OrthoDB" id="5825849at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033620">
        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278">
        <property type="entry name" value="CHCHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9635817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14078" checksum="1226A433E3346733" modified="2021-09-29" version="1">MRLHPILFAGPPKSGARSPQREPIPFKMLLPLQLKKTVSGKGDKLKEAACMQEMAVMFACFKKADFDQTECLKEVAAFQGCYKEYNDRITTQREQGKKGILVPGEKKLTHRQLNQLLKSFPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KVZ9</accession>
    <name>A0A835KVZ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001061">
        <property type="protein sequence ID" value="KAF9404167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KVZ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000306">
        <property type="entry name" value="3-carboxymuconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37692" checksum="F216B42404AE260F" modified="2021-09-29" version="1">MQEQILLGTYTRRVSKGIYQITLDTSKEVLSEASLLIEETSPTYLALNEKGDLFNVTSVDGDGGMAAYANHNGQFDLINKVSEAGAPPCYVAIDEEKQLVFGANYHQGIIHVYRILANGHLEDADKVVHDEPTGPHENQDNAHVHYTDLTPDRRLVVCDLGTDRVYTYDVSAEGKLSEVAQYVAEPGTGPRHLVFHPNNQFAYLFGELDSTVTILAYNVADGSFTQVQKVSTLPDGFNEFNGGAAIRISADGRFVYASNRGHDSIAVFAVTEAGDSVDRVQLISTEGEIPRDFDLDPSGKFIVVANQNTDNLTLYRRDEKTGLLEIIQKDVYAPECVCVYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KW04</accession>
    <name>A0A835KW04_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001054">
        <property type="protein sequence ID" value="KAF9404190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KW04"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16999" checksum="A9A4B77A6BFCC34E" modified="2021-09-29" version="1">MDTANYILKENNHLDGLTLQYHDSLRELKFGKREGVEIDHKDEQTSYLRNRPDLYDPSAFGGESIDELVARSTETIEKISAEYPNGNVLIVAHGVLLITLINVLAGKEKAKWREGGPLANTSISILENKQGESIYTITSFNDVSYQANNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWV0</accession>
    <name>A0A835KWV0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000674">
        <property type="protein sequence ID" value="KAF9405835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14154" checksum="EB8C323538B497AD" modified="2021-09-29" version="1">MGSKEIKSVFVFICAGKSMVWDDGGPLRTRPITTTHNVPAMWKVDQLVWKFTSGVTVDIEVTHKVKQSNVAVPNLDLKVSEDVPPVQRSAPLLQSPQYTGGRPQPYILLSLPTPKRDERNDCLRVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYT4</accession>
    <name>A0A835KYT4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000614">
        <property type="protein sequence ID" value="KAF9406273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="309" mass="35969" checksum="1926F517D3780D41" modified="2021-09-29" version="1" fragment="single">ENANNLGCYCCTTYRRHNLLSGCAVITTRHILTTANPTVLILRSYGHMLTFESILGGWYDTNANVYNSSMFFVPARIHIHPMYKYDYEVNVSHPIPVMYDLSLWAATHRFYGEWYYLSGAVICPRAASGWSEYASTIPRAFDLSVVVGFQFMKAYHRRPMPWYKYGVRTKSYVWPCPKSDWHWYHCIMGEYWGRLGFDSGGAMHMMMEGKSKRNDGLAGMCSFSLKLRAMQTTHYFTVLDTHPVLDFLYDAFLGLSECAWLDDRFEDTKWAAPIPWHDVSIPTYYSFGWEAYRVYGGYIYGDSLPNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ72</accession>
    <name>A0A835KZ72_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000851">
        <property type="protein sequence ID" value="KAF9404941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ72"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032383992" evidence="1">
        <location>
            <begin position="34"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122087" checksum="6D2A1B7F580F49A9" modified="2021-09-29" version="1">MSQCSLCVGMAHRIKIRFLLLLLVLFAVKNVCSDFIEMDMDITELSQVLPLIMKYHGKYKGIGESNMDNLIKTNPSLEKLMVKAQGLLQIKLLEWADVVGQVALIDQQLTRFVRETQELESDLLVDYAEWVVSHDHAAVAGLMEKMRSLVSPLFRSQGVLQLAFKFTVPAMSVRRLRSFRVLLVILVFANTSRALVDEVLDVLKLGKEVGEEVLNSWDVFGKPFNATGGVDLPVVRRREREILARLAVVSRSIEKLEISVQKVGDVALFLAKKGNKPTRLELRLHEMSDLLNRVAWSNRQMREYVGLQEELERSTLQDFAEWCVSHDPGALPGLLERVHALVVPPHKNLLGRGLLQLIMDDLKRLSTSRSALERPHSLRSVGPLSSRQSVVTMRVAALFALFAIGLATELTPTDLIRQRFYDLEEELWRNVTDPLWRDSGLGGDVELTKAFFALNEQIELIPRTKRLTLRSWLWNKVSEKLQVVDGFYKNFMEFVSHQASPGAVPAPVKEWLDIAESILMDPKTSVAQAVRKIHGFLEHGDIFRSVVQDEDSDVCDLQMSPHQLIYDMYNTIALTEIKGYAMMQFSWMLLRIYGRGNFTQEASLTRQRYSERTGQTATAARSALAMSKRDLYRCDPPVHTSATYAEVTRLLQGYVENEVDMNSDGTCKENCAFYTLTENHGCYSDQFCEKQEKCKGRIIDCQYLDSDMWVCPASRHSQRRYEWIEYENGRTLGRVGSCRLGTTKVDSWWRWLFWHCSYCMCLCDDATGSHRFFSLREATSDIDNNKSTPGGDGHLLTARIAFVYARTKPAWLNVSSVYEKRWQMLIKTSQYLRGRMRLVKLGKVFHIQIYQGKLVERGFVESSEEVLAQAFDPEHAGVLEGVDYHTLTYERRAIDLDELDSPSGHVLTGARFRMIGAHLHFEIRATPFNYTTGKLHPEKSQWISNDNTEGSHTPRSRLELYKPDLPTRSHTVLRIDSQHDQYIEFTHSDFDADAAQSTVPFIDVQPVVPSKALNTKGATLLSGAGLYHRGARGSGGFIGVKVITYDYSKHVKAEPPPSEFVDESETTEFVPIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZE2</accession>
    <name>A0A835KZE2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_012063</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JACKWZ010000403">
        <property type="protein sequence ID" value="KAF9408156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="59"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="412"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="596"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="661"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9408156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="778" mass="87008" checksum="58403991C9243863" modified="2021-09-29" version="1" fragment="single">LPVYAILSIILSSVVVVLAVLSVFIYRHYKLEAEIAMMTWRVSWSDVLQPGGRLRGSMHSLARRYSTGTTFSDEATSLAGDRQVYTPCGFYKGCRVAIKKVDKQRIDLTRPLLLELKKMKDLEHDHLARFFGACVDPPHCCLLTEYCPKGSLQDILENESIKLDWMFKVSLMHDIVKGMHYLHGSDIRSHGALKSSNCVVDSRFVLKITDFGLHALRTSEKDSRAHSYWTRLLWTAPELLRTAEPPPEGTQKGDVYSFGIVMHEIVNRQGAFWLGPGIEMAPKEIIETVISSGLRPNTSHHRERSCEVDDATDLMRRCWAEDPTERPDFAHLKGAIRRLNKGQASSNILDNLLSRMEQYANNLESLVSERTQDYLEEKKKCEELLYQLLPKSVASQLINGQSVVAETFEQVTIYFSDIVGFTALSASSTPMQVVDLLNDLYTCFDSIVENYDVYKVETIGDAYMVVSGLPERNGTRHACEVARMSLALRDAVSRFRIRHRPQDQLKLRIGLHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSPVTKALLDPFGTFNLECRGEVAMKGKGILVTYWLLGEKVDPNAPKDKPSLVKTQTLSTESGSLSHLTPFRQRLEQNSRSSSRRGSGIFIQRTDTSKLEREVQPLLQNLSIQRQHSDPTEPASNGISDNGDDVDKQSVSNSISLNVNSLNHNSVHSSQPRVKLKDLQNQNSVGNHKTNKIGNNNWISKLPTASSFDNGTKKGAERLKDYSSVPLLSKADTPNDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0B2</accession>
    <name>A0A835L0B2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_011734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0B2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9408670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="43907" checksum="F475610721F46275" modified="2021-09-29" version="1">MTATAIEIDSCSKKMAAIGMCETPGCKSIAQLQCPTCLKLGIQGSFFCNQDCFKKSWKNHKIIHSLAKGESTDASSVEYNPWPSFSFTGKLRPFPPGPKRTVPPHIGRPDYADHPTGFPASENAVKGSGQIKVLDDEEIEGMRVACRLGREVLDEAARVCDVGVTTDEIDRIVHEACIERECYPSPLNYHNFPNSCCTSVNEVICHGIPDLRPLEDGDICNVDVTVYHREFHGDLNETFFVGNVPESSRKLVQVTYECLAKAIEIVKPGEKYREIGNVIQKHAQANGLSVVRSYCGHGIHRLFHTTPNVPHYAKNKAIGVMKPGHCFTIEPMINEGGWRDEQWPDHWTAVTADGSRSAQFEQTLLVTETGCDILTQRSTGRPWFMDQLEKLNAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0L0</accession>
    <name>A0A835L0L0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-adenosylmethionine mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000283">
        <property type="protein sequence ID" value="KAF9410004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0L0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="94"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="189"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31230" checksum="7A2279EB6CC88F21" modified="2021-09-29" version="1">MERKNKPKSFKATHFPPLLAGAVAGVSVDVTLYPLDTLKTRLQSAQGFQKAGGFSGVYRGLLTVAATSMPTTALFFASYEATKTLCQPLVATQYTPLVHMFAASVGEVLACLIRVPTEIAKQRKQTYVGTNSKSSISILLHAYKTEGFFRGVYRGFGSTVLRDLPFSFIELPVWEMLKTTVRKYNDGEISSFQSAICGSIAGGFAAVLTTPLDLAKTRIMLSDSYRVSGKMKIKPVLTAIYIESGFKGLFAGVMPRMTAIMIGGFVFFGVYEDTKKYVEKYFDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0R2</accession>
    <name>A0A835L0R2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000324">
        <property type="protein sequence ID" value="KAF9409330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0R2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9409330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="43874" checksum="C7012EB3BC59515C" modified="2021-09-29" version="1">MEEQQKKIYYCSYPGCASYFDRPYRLAQHFLAHNNIRPFPCKQPNCNKAYTSKSHLDRHINSVHGPQEKDVVYNCSECSKTFANRQNLKRHLNTVHAIQFTCDECKMTFKKKNQLTAHMYQHTGIKAFKCDLCPDTFVSLYLKKRHMRYHKTYKCEDCDLVFNHWSKYQKHKKSEHVQNYSSTPQQLKSLKSLFESNVTVIHPKFNLFLPGGAERRMFPSPSAGEDAEVFVCNECKRTFKERVHMVRHLKTHGQKTITKTFPCPYEDCPRKSNLKQHILVNHMKMYHKCTICQAELSTKAKLNYHMQLHNKVNSPVVPDSNKERKPRKDEGTFKVSTALKLSGLPAPPENTHVTSDTLVNMSEQPEHIEVEVDVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1J1</accession>
    <name>A0A835L1J1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_014375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001005">
        <property type="protein sequence ID" value="KAF9404363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1J1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9404363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="181" mass="20117" checksum="ED0C37A694B6DF0D" modified="2021-09-29" version="1" fragment="single">ATIYVGGLDDRVTESLLWELFVQAGPVVNVHMPKDRVTQTHQGYGFVEFMGEEDADYAIKVMNMIKLYGKPVRVNKASAHQKNLDVGANVFIGNLDPEVDEKLLYDTFSAFGVILQTPKVMRDPETGNSKAFAFINFASFEASDAAIEAMNNQYLCNRPISVSYAFKKDVKGERHGSAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L271</accession>
    <name>A0A835L271_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000288">
        <property type="protein sequence ID" value="KAF9409932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L271"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="24982" checksum="FC1EC100F59A8D28" modified="2021-09-29" version="1">MSFLVKQLARRVFTPAVASVKKVNFSTMFVPKVQQPAPNFEATAVINGEFNKLKLADYHGKYVVLIFYPLDFTFVCPTELIAFSDRAKEFASIDCQIIGVSTDSEFSHLAWTNTPRKDGGLGKIEIPLLADYSKKISQDYNVLLDAGFALRGLFVIDRNGILRHMSVNDLPVGRSVDETLRLVKAFQFADKHGEVCPANWNPDTNAATIKPSPKASKEYFEKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3C2</accession>
    <name>A0A835L3C2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Orthopedia</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3C2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="5">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20350" checksum="B285BE1E7902AC1D" modified="2021-09-29" version="1" fragment="single">VWFQNRRAKWKKRKKSTNVFRSPGALLPSHGLPPFGAGDVCSPGVFADRPWSMPAGLGQLSQGGVSMGGFGAGGLPQLAADLNPSLPISSVASGQPYQGHYPLNSLGDTMMSYCNNISQQQQGALEGSPTPPHMAHCGNNNASPTASGNGGEPAEEEVWRGHSIAALRRRASELSAAIPPYLQLNYDAHSPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3X0</accession>
    <name>A0A835L3X0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3X0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="44626" checksum="544244097D4369E5" modified="2021-09-29" version="1">MKVRDCALLPTMVQLDVTGAPLYPSTLTLNDLPNEILIYIFSMVDFESLLAVAKVCMRWQQLCLTPCVWDKTRLIVCMKNYVRISENIVPFVAKYVKNVKLQYFKLYSQVRASLISYCPNLTHLEISISQVDSCIFDDLGCWPNLKFLSFRNSLIVKNPENANGNFVYHLPFDKLKNLETLVLSNFALTHDSLYKMLQCSNLVSISMEKMKNIPADFLESLLRTKQTTLRALHIYGDTLNDDIMRHISNCKALQVLHIMTCKTLFDSSLLHLYRLKNMHSLKLRHGYFSTSALLAYFTNNTFQNLTYLSLSRCLHVTMQVAKAIKTSAPNLQELSFYLCPFIIAPNFDRCIYIVDIFVFKFQCIGCASGLKMVLSDMIERYKRSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4D2</accession>
    <name>A0A835L4D2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_006623</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4D2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9415871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="342" mass="39653" checksum="EBA83B7CBC5C21A8" modified="2021-09-29" version="1" fragment="single">ALKLYGDRLSEWERNEVRKYPEVWFLGLDSNKVQARANLPNNCGFDDENGSYNKQIHDHIAYRYEILEVIGKGSFGQVIRAQDHRTGTQVAIKIIRNKKRFHHQALVEVRVLDHLRLKDKDQAHNVIHMLDYFYFRNHLCISFELMSINLYELIKKNNYQGFSLSLIRRFASSLLRCLRLLEGENIIHCDLKPENILLKARGSSSIKVIDFGSSCYTHARVYTYIQSRFYRSPEVILGLQYGTPIDMWSMGCILAELHTGYPLFPGENESEQLACIMELLGPPPPDLLLHATRKRLFFDSKGCPRSITNSKGRKRRPGTRALTTIVRSDDPAFLHFLHRCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4R8</accession>
    <name>A0A835L4R8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0415 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4R8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041076">
        <property type="entry name" value="DUF5614"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18474">
        <property type="entry name" value="DUF5614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5614" evidence="4">
        <location>
            <begin position="11"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1308" evidence="3">
        <location>
            <begin position="233"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45504" checksum="D09F6DC8A5BDDF4B" modified="2021-09-29" version="1">MATSEELMLLVNDKITLGENLVVKLEPLNEIDGVTKLQRKIKQEIEFLQKLKKSKNVKIEQLSCSNLRHLGAMVELTLRPGVIAVCKIFHINDTSKLVIDIISEEGRVWTKVIARNPKSLSALSAGKASYGARSILDQAEDYLECAKLYPCMYKPPKVIFEFMSGIEENLANKLKSVGVTVKGEILPNSNLSQDIKDLWSEESSDEECRQHSEDSSLNPMPECMDEHPEIKTLNLDVTAMMAYVSNMTNGHCNYIFKQEVLTQQAAWEAERPVKPILERLFKDKMLVCCRTAWDDFEKIVNTLGGPMEIKRTQELKNVVKVYPDDYGGEDDYPRKNLKVRGHVRLRSKIIFNFGHRIKTLTVSANEGFVRAAMQQGITYASFVHESRALTESKESTATKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4V7</accession>
    <name>A0A835L4V7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58116"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62016"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="Rhea" id="RHEA-COMP:16011"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KDELC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4V7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF122">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="11">
        <location>
            <begin position="227"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="500" mass="58208" checksum="647378F745836A86" modified="2021-09-29" version="1" fragment="single">CNKNNNMKLETIFSFMFLYVSSYTQNNDIILIGPGLNPKAIVMPARYFFINFTHINAQSYTPEINKNLVVEINGKSSDGKHCRVWVNKLDRKDGTFIVRYKVYETCLELSIHVLYGKKDVAKSPYKFKGPTYADQCNCPEPQFEEWFKNYGCEKTYEQIKKDLKPFNGLNMREELQKIINKYHQPESTSFCHYAIKQNELYRNCYGKHVGFNMFSDNILLSLMRKVKLPDMDLVINLGDWPLVHKKDKPLPVFSWCGSDDTYDIVMPTYDLTESALENMGRVTLDTLSVQSGAEIAWDEREPRAVWRGRDSRAERLKLIDIARANPDLFNASLTNFFFFRDKESQYGPKQPHISFFKFFDFKYQINVDGTVAAYRMPYLLAGGGLVLKQQSPYYEHFYPQLVPWEHFVPVKRDLSDLVDRVKWARDNDDKAKQIAGNARNFANNNLLPQNVICYHAALFWEWSKIINNEVNIEANMTHVPQPTATNCDCKPKKPNTHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L577</accession>
    <name>A0A835L577_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L577"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF15">
        <property type="entry name" value="FI05267P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="546" mass="60773" checksum="3FE8E08650B591FD" modified="2021-09-29" version="1">MSNYDQGSKIILRSINGDFRSGQLTAILGPSGAGKSTLLNILAGYRVAGASGTIFTNGEPRDLHQFRKLSRYIMQEDLLQPYITVQEAMMIAADLKLGNGITKEKKLVIAEEIIQLLRLQKARNTATERLSGGERKRISIALELLNNPPVIFLDEPTTGLDDVASSTCVSLLKRVARGGRTVVCSLHTPSARLFAEFDHVYVVAGGRCAYQGTAPGVVPFLNELQLPCPKTYNPADFKESPPGELFEEMEIEQLNTGGIEKHNYKHGCSACQQFIVLLKRMLLQTVRNKMGYDASKTIFNFGFCYACTIAMLYIPMMPVLLAFPTEVQLVKREYFNRWYGLKPYYAALVVSRTPATIFFSLLYLVIAYPITSQPMELDRIFMFCSTCILIALISESMGTVISSMLNVVNSVFMGPAMSVPLMLLAVYGIGSGDDPLPIVWRLARACSFLRYGIEGLVAAIYGPPRDDLICPEHVDYCEYKNVAYFVKLMGMSGVSFWVDFSVLVCMLLAMNLTGYYLLRQRLSPNYAFRAIKVIGNFIKTKMSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5X6</accession>
    <name>A0A835L5X6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004870</name>
        <name evidence="3" type="ORF">HW555_012145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000412">
        <property type="protein sequence ID" value="KAF9408033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000058">
        <property type="protein sequence ID" value="KAF9418251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5X6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="35348" checksum="C8C4332CC8770475" modified="2021-09-29" version="1">MSCWSNEESLSFLEHYQMEPCIWNPKDANHKDKKKQADAWIRLAELTGRPVKEIKNKKEILMTTFRKHLKKKRESMRSGADQTEDDPLIRVSTPSRPPSRSPSRPPSIQAVTNKRRRPASETAEKQMAVAFGQLTNVLGQRQNENIPAHKDDDCDLYAKLLAIKLRELSTDERKIMMYQIDGLFINRISQKSNERHTPYPQYYSRPSSMAGAYSTPSPQVIPSRPTSVNSVYSEPIHNNQSFFPSPNTQTSYSAPDMTKHIPTPIAPAPSTSTAPSSSIRIISDQIINPTPRETNIINMAMLNAFEDFDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6C3</accession>
    <name>A0A835L6C3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032440061" evidence="2">
        <location>
            <begin position="17"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="23441" checksum="F633EF0B1DC6D79C" modified="2021-09-29" version="1">MKIILIISVLIISAKCGLLDDLVTEEQKSRITNLLGKKPKPDAQKTEYHQGMLVKVKETLENGTKIIIDALGNVIKINPKEDKEIPKTENTELTTKKPITGAETEKDEANKTIDNNPDKPTTNATTEEAQKDLNETASKTEDQPKNNTLSTKDDGKVTDDAKNKTDANNAAGDDKLCTDDKPCDKVVAVTRTSFKGDECPAGKDRADDGTCVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6K5</accession>
    <name>A0A835L6K5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6K5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041406">
        <property type="entry name" value="CSN4_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="246"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="COP9 signalosome complex subunit 4 helix turn helix" evidence="9">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="342" mass="38934" checksum="535DD2725BBB646A" modified="2021-09-29" version="1">MPINLQGVRQYLSELRNSGGLHKDQAEKYRNVLMEILKSTETELAESLKAFVEAIVNENVSLVISRQLLTDVSTHLALLPDLVSQEVSHFALDVIQPRVISFEEQVASIRQHLADIYERNQNWKEAANVLVGIPLETGQKQYSVDYKLETYLKIARLYLEVDDPVQAEAFVNRASLLQAETTNEQLQIYYKVCYARVLDYRRTTAFQNVSYLIQRREMSTVTSIFYFGENVLGSDHQALGAARATTSDGTTILDRAVFEHNLLSASKLYNNITFEELGALLETPPAKAERIASHMISEAREILPQWDKQIQSLCYQVNSLIEKIAAAEPEWMAKLMEEEMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7K9</accession>
    <name>A0A835L7K9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G kinase-anchoring protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GKAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7K9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026109">
        <property type="entry name" value="GKAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14899">
        <property type="entry name" value="G KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14899:SF0">
        <property type="entry name" value="G KINASE-ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02083">
        <property type="entry name" value="GKINASEAP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35586" checksum="4465624F60B86F27" modified="2021-09-29" version="1">MAQLVVQSRFAGLKIEDDDYPPTENQKSKKSKVNNTKKTEPPKKQKNVTNKPQPGPKKKKSKPQQVSADQWELWKQKDEEMVVGHFEDELQQAILLSKLDFEKEEGRVYLQTKENAELEETINELSKQEAKKLKKKNVMSLDQFNDMMNAGEELKLPPHANEKCVQEVPKSPIKDPGFFDRVKAETKKELLKEKVVDKPRVQPPISNEVITRLQFTDALERKDQEIATLKEEVENLKHELFTVKCRNKKLCNILGQGEMKDKAEVLIEVERLRSVQAELTAELASLHTDLEKERSKNTDPRVHKDKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7W6</accession>
    <name>A0A835L7W6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7W6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="416" mass="47328" checksum="1005014C04644623" modified="2021-09-29" version="1" fragment="single">TLNIKPLSKDLEWSLDAPFGASMEATGASGADASAAPIACTSSEERALRRVVGRWGADWPADHPLPPPRWGAPRPALRLSLRQYEDLVAKAEALLSRLVVSENYDSINNFISLYDAYMAAPDATLQEYFRKYNPPIRPHKHTCVGLAMEVEKTLKVLEKDFPGISKSMMIVSCDENIQDLMDYATFCPGPQGFLIETEKDHVMLAINVKVDGRPGMFLSDLGYHIARVVTVMVDRCYPHTGWFTQSDEPHCKEYNYQFNLQNSNYIEWHERETRGTVVKERLSLVYVAKAYLTAVSVTEKRNIVWDLRSLLARDPKGRLTAGIYFPIKKKDQQFTMFFDANTGKQRKKLKFETFLELQKIPDEVVDEVEQCNDQLRLRDGELLSILNKLATIMSDEEYMVELMEINDKIVQLSAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z5</accession>
    <name>A0A835L7Z5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000158">
        <property type="protein sequence ID" value="KAF9413476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9413476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13894" checksum="98EDE35C61C364E2" modified="2021-09-29" version="1">MATTSKPRSEMTLEELAKIEEEEFSTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPRLGKGKRFCQIGKAVNKDRFISKMFLRGDSVILVLRNPLATAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8H4</accession>
    <name>A0A835L8H4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000140">
        <property type="protein sequence ID" value="KAF9414171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8H4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="766" mass="85117" checksum="7E6560843C78B14B" modified="2021-09-29" version="1">MKNDEPPLDPCEIQRKKKALAAKKKCVKKVVCEPPKEPEKVKKCFKEPPCLCLERIKNLPIDASTLKSDQAILEDLRFTCVVRPQLPGQSRCEKIRELETNHPDTSLPNCEPPPPPPPPPKLDPCEQQKRRAKIAELNLEIPIDSEDDLIDSRRLTIHPVNNRCETSTNSCNNFDKELTELENLIKKLQCEIGEMAKYSNKPVSKCKNIVDDKDCGNKVDVKDCVLIKDEGVLEQQAKKFTGNMSNSIKISGPENDTLDDVRRNFSMLWDDETTNSIEDATEDIMTINDCPPKPLNDPSFKPSDNPKIHLINNDLIDSFDNSNTINTQQELGVNFPVDLKHSSSIHKTNDDNTPTKVNDPNSTEFCEKALTVSEKCNPTTIMHSESSGNQLKDNTKILNHEKDSSATVTVIDKSKEIKTEKTDLHNAMQNAISSTNEKTSIPKNPMNNPPVAEKCSAKSESFSIIKTLRRIVGKESVKSIQKEKQSQDQESLTDSSKKIDNSTSKKDSFIIKEDPKIDTKIIKPAIAQDVLPKLSNKDSDHKEIQHNPSSTVTKSDINEETSKTTEFNPTSNIEIKPVIVNKLLSEKPVPSAPSANSNDLVKLTTNSASQTIVPVNAKRTNQKPQEISNEISNINSVQDPNPVADISTSHVTIPDGFNKNLVIEDAKTILRHATNDAVKRSEAIENHGAVTDGLAEGDIHYKCDDFFCPPVALRSVGLRAQAWATNPHGSQPGGCLTHPVHRLHDFSNAFVQVARNSSFELRSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAL7</accession>
    <name>A0A835LAL7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9422249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1906" mass="214008" checksum="0ECDA1CC8AFC0782" modified="2021-09-29" version="1">MNALLILFLIFVVIYSCVSWLLPTLLAWLFMRKYHIKLKIGRIAVPKLILKDVSLSKDRYSIHIDEISFQSSCFNSEINKLVSVVIRGVEVTNNVEEKKNVVVETILKPLLSKQNSTARSDSYEDMADFSNLESNLNRIANKKLLDFRDKKLPPSLIMFAQFMGVHIFNASATIHSGTENPWSLTLTAAEVHADGAAGGPARALVFSTKLVEAKAKVVGKGECLGEAACCLVIEGTVKADGPLNVEKIHALVSNTSVTFKDESYQFLKSQKKRRRTPALHVNDEDHLATLIPRFSPVIPKIFSLKIDSTRISCKDKTVNTNFEMSLQSLQVNSRFSAASVHYDETGVEVGGLPQVYVAFQMEQYQLVADAQPLAVLNKLKLDAKLEKGVLNLYLIISTLNISYSHTDAFKWYKSVKDKIRKAQPLQIMEVESPYPSPPVWLSRIFSSCIVQGCAELRAVSVHARLTNHNALGFGCSGVKVKLDQLLETREEWYRCSVARQAVGGNQWGAELLVDGGWMACGPVALTIRSPPPRRHHTWGEALLAVALVKWATHGPNDSKVEAMVDCLRLEWSPVIAQTIISLADCLNEYKTPSARVQDLEEVPETSSNISVNVALSHINLFLIVNEDMCLMTRVDAVTLEKNVSKSGAVISGLKVVDIVPYKGNIHCQRSDEIPSTFFHVKLARIEYLLSKEKFSALLDVQFIENVDLEWSANLHLKVLTFVRAVKEFQQELRVRRSEVVKKKGRALDWRVAFKGETNLGLILSKENNMLFATDDMTIAYDHEIGLSIVWSKLNMILNGDEVIMVEGYSQERVADDLEVRVERKANEGFALTWNKVWLVTVDSVRVVFPYKHRFAEAVQGDFVSLFKWIKLVHGIKKKPFTVDSPLPSDLHIKIEELLIEMSDDPFEVKLRDNYELLEDEYKESQKRRTMLDAKVQELCKPHLFLPAGKVEELYAALRQKDAQIYVQRCRAAPPPRTRLVACCLSRFSLVALADPTIHGTQNAQARLREIDHDSPWPEDGIEFTTLWCRSINMSCSQWQLLLRDFPQPLLSMSELKMWGTLLAAEEQAPPRAVRTVTIDQGAPWGEQELERSMMPLKWYYDLCCEMAEYSYAFGPCWEPVIAHCNLSFDQVSRPSLDPSAPLSWWDKVRLLMHGRLTVNCAKFTCLLHVSLDPYNTTEEMEVTWTDLVLDWTNGRLGFLGTLDVYVRTASKYDDCRVLRVPALRLSVKMGWQCVADPRDHHAVAPCAPTRLPEYSSNQEHDSYRAFRSQGLDLHLSMETKPVDKEGNGPVLLLWFESLKLILSGITRPTRRGRIFKNVRPRKPQLSRHYRNVSVSVTLHNLQVFYWSSSSLQRGIEMLGVRVTCGSKHRLSLVATNDGLVRRPRANWTTVYMNCDLNDAEIWLKTLAADEKDGEEYSGLTPRVLEKCYCLSVRRVSYGREAGACAGAPPTHRLAVHDLRGAWTKLNRDLAFALIDTYIKTQQLKKNLSTKALKEEEQPNTSPKHQREADVISPPPPVNTQSSGVAAGCGGGMLAALVAEAGGAAPVVFSDELSGAEADAPPPIATHLRHELDDDNSHTACLKNIQWVSVEEIEERWQSAEISTLPDVPRLVGSGHSAGGVIGRTVGPSADTGLAQLQRIVSRCACEFYYVSHEEAESVSGQGTGWAQQQPYDSFTLMHHDLNVCTNSLQVLVPQEPSGRAPLARRAALRVFCRDRPPVGGIAVKEHFEVNIVPIKIEDGEEETEGTLKSGASSSSLVSTGSKKIKKKSKDSNSNFYVKRDKKDKDDVEKMKERAEKNKLFIYIKIPEVPVRVSYKGSKEKNLEDVRDLPLVLPTLEYHNVTWTWLDLLLATKSDTRRWLKVNRRRKALPACLNSPNHSNISLSIHGSEANILINVYGNELALFIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB39</accession>
    <name>A0A835LB39_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB39"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007112">
        <property type="term" value="P:male meiosis cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057508">
        <property type="entry name" value="SHCBP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045140">
        <property type="entry name" value="SHCBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695:SF4">
        <property type="entry name" value="PROTEIN NESSUN DORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695">
        <property type="entry name" value="SHC SH2-DOMAIN BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23762">
        <property type="entry name" value="SHCBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHC SH2" evidence="5">
        <location>
            <begin position="30"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="362"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56511" checksum="712758D78189AF87" modified="2021-09-29" version="1">MMPSVYTFSRSDNEILQELLKVFSSGRGTTREQWSMQAELLVEPVGWDALWKLSKDFCKKFEVRFPCIAYVTVTSVDFENLSACVDVLSVQHETVSLPENIVDVPLIELWPTIKQREQCINVAATAEFIDLLRFYYNDIWMPWDDSEVLLSNTIEERMQLWSDMHNGTIPNFVARSITLLRNSAIDAHEKLKQMDSSLYSLLPPNYISLCAEMNARLDGLMSKWTLYENSLIREQYLARERSKWQRNKSKKNVVAVWQGGSIFEFSEISKFLISHVTNDFRLSVLTSVEDALQLEPHELVLCGHELLLPEMPLANINVTSFNGATLQASDMRSCLLMLSEECRLRELTLNCLSVNTVIVMRSGTLHIVRCNILDQSSSSKSDFAQGVVAMSGAKILIEDCTFDNFYSGIVVHKGAQVEFRNCTIKNCGVGIQMYSGSQVELSDTVISNCSEQCIRCEVDVMQESSICTANGFEGLLVNANCKIGTGDLQKEVLIVKQDVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LD57</accession>
    <name>A0A835LD57_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_003537</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LD57"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032309502" description="Alkaline phosphatase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9420124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="495" mass="54755" checksum="76AEA88A4FEA753F" modified="2021-09-29" version="1">MRPRSILAFCAFIVTVRSALRTDRQFWTDLARNELEEALKVKLNLNPAKNVILFVGDGMGPNTVTAARIYKGGESHRLVYEKFPHMGLLKTYSANKMVPDSACTATAMFSGVKVNQDTIGVDASVPHRDCEASLQSETRLKSLAALALEANKSFVTTMRVTHATPSPLYAHSASRSWECEASLPDNSSCKDIARQLVEDWPGRDLQVIMGGGRQQLVSNATGTEHDPISLSPWTCYRQDGRNLIEQYKTDKSTRGLKHSVIMNNKELAELDVNNTDYLLGIFSNEHLSYEHERNKGPEGMPSLSEMVGAAIKVLQKNKNGYFLMVEGGNLDMAHHRGWAKIAVNEALAMEEAVQLAADMTDAEDTLLIVTSDHTHSLSINGYPDRGSSIFGIAQPSSHDKINYTTLSYATGGPGSFQYYVHTDDNGSRVMRRDPSEDDTEDYKYTQVAGIQLVENYHGGGDVTVYARGPYSHLFHNVHEQHYVFHAISHAAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDI8</accession>
    <name>A0A835LDI8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of many from the eggshell of the gypsy moth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the chorion protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032915750" evidence="5">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="192" mass="20324" checksum="813B91EC884BECD0" modified="2021-09-29" version="1">MLVSYCLFFMAFAQFSSAQVFQPGLINRPFNAFNTGPFSPNQLHQANNQFQNIPLATKHGLIYHTNNIANTNKFANTLANTNSLTSAILPNEFIGGDLLANVGSSITNIANGIQTNRVSYNFGDSPIPITVSGKSLGNQPIGLQIMADNLQVNGNVAVSGRMPLYGTVTINGNVPSDGKSTVNYGCGAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDV6</accession>
    <name>A0A835LDV6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4771 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDV6"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031935">
        <property type="entry name" value="DUF4770"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031936">
        <property type="entry name" value="DUF4771"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41967">
        <property type="entry name" value="FI19406P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41967:SF6">
        <property type="entry name" value="FI19406P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15994">
        <property type="entry name" value="DUF4770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15995">
        <property type="entry name" value="DUF4771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4770" evidence="1">
        <location>
            <begin position="114"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4771" evidence="2">
        <location>
            <begin position="488"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="77028" checksum="15DDA08D676D4E79" modified="2021-09-29" version="1">MGKFVMPPFRKLMKQKPHFKKKDPVWVYLEREMLENLSKKPYNEKVGKWLRYLKDLKAYFRSEDKRKERRLKNEVGPKWYVELSSQQREVLAHMKLMIHQDLLEDVTRRLRKALSDLGITCKISKNILMKAMEESIEDPGVFFWNLYQGVYNKPPSELLPKYDMNAMIMISCLVFIDMEECIETLDKLTYNKKNVTTESKKPKKKAPPPKVKYGEYLQKFHVPFYSTHQPKKEKKKPTPLSYKFKVRSSESLEVLCKSTLFLEKRKERNRKEKEVERPCTYKFWEAPNTLRNTDPKMIAYVNKLRMLKLRPKHRFKTPFTHVQYLISGVAFTGGRPHYLLSNVSLLPTGYIAINDGIAVSNGETVTCIDGFWKYPRTLNEKCDVKCDCITKWEPTVMKYLHESRCKCGHLYDMYNTGVRNKEKYFYPPTRHGPFWFDKAKIYQLDSMEDFIKDTFEEAMRSDQVTPVPSMPTLNAFGLKESELIGAFLADLAETTPLLIPHLPEANLLNNLQQWARNRVKGNLTPKKHKNMLLQSQRRWLELKHMDFRARAKPIPFTLKQLKSMKWSHRQLVQRLHDYQMNDFVTRNRIKQLEQTRLWWPTCKYDYYPSKPFLDIFFTYMPGRTKDVHLINPFSAELTPKSGARTCPLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFE4</accession>
    <name>A0A835LFE4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFE4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF114">
        <property type="entry name" value="IP04436P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032339093" description="UDP-glycosyltransferase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32893" checksum="F2BD6508C60658F8" modified="2021-09-29" version="1">MRTLAILLVAIFAVNVQSARILGLFPHTGKSHQMVFDPLLRTLAERGHDITVVSFFPIKNPPANYTIVSLEGLAAQGVETIDLSYFDIQNKLLNSLGIEKIIKQIFDFQPLADMATAICSNIVDFVPLANAMKKSYDVILVENFNSDCMLGLIHVYGLKAPYISLSSSAMMQWSADRIGVTDNPSYVPLVSSEFTSQMTFLQRLENTILNVYYKTWFRYAIQMKEKAIIEKRFGRRIPDLQEIAKNVSVMLVNTFHSLNGVRPLLPGVVEVGGMHLDHSRKPIPHVSKYFVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFX3</accession>
    <name>A0A835LFX3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFX3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1208" mass="138784" checksum="58FB723628D630F2" modified="2021-09-29" version="1">MNAVTGRSISFNLFANIQLEEFIFGSHRQLQELITCEISYGYRAAGENNTEPHSKDDKLPTWDDLKQFLQSRYRTLELVMSTSGIREKPVKERSHLVTATATTSPSSEHRKCVLCKENHTLCHCKDFTKLQPVERSEYVKSNKLCFNCLAPGHSAYQCKLRMNCRICSRRHHTLLHRSKDSASSVQSEDSKQPKAIQHGVEEKEEIVNTTIASHHSAKQSTSLALLATATVSARNEHNHTVVLRALIDQGSQASFISEKATQLLKLSRHTARGSIIGVGSTRTNVDHVVQLRIGSRWNPSFEINIQAYVMSKQLTTKIPSTAVPVTHWPHLEGLNLADPDYHKPGPIDLLLGVKEYAQLVQQQLIKGPPGSPCAQKTNLGWILFGEINTSLQEDSFLMDLEEGLTSQFKEFANLRELIQVITYCRRFLNFKRSLENTDKDFTTKELEKSLMKCIELAWFSSISLSPRGVGRTEMVARSRSASRSVARSSGSRANCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHIHAAHHRAPHHLRRRLLHAAHTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTARRTTSAADPIDPVYTHIHHYYCTPHMYTAPTYQTHPYTNTTYHTITIYGTLLCRGDPERRPLAVARVVVPPRVAGSCRARSPRTAPAIDQTSSPEALQIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2M8</accession>
    <name>A0A835G2M8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000532">
        <property type="protein sequence ID" value="KAF9406895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2M8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032644488" description="Receptor ligand binding region domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17301" checksum="1FEC05E7D8BB76B3" modified="2021-09-29" version="1">MNVWCVLVFLGLVGVGFSLSQNCRGEKPRLRECDNVCDKDGNCKIRAALLLPKNTSYDACLSVVGAVLDLAMEDPVIQNAFPPWLSVEWMKYDVTDCDAAYAVISAIDAYNDCAHVFFGPSCDFALGLRSCNINGYFALLVRRLNLRLSGCSSTLSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2X8</accession>
    <name>A0A835G2X8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_004904</name>
        <name evidence="18" type="ORF">HW555_012742</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000503">
        <property type="protein sequence ID" value="KAF9407140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2X8"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="108"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="206"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9407140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9418198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="294" mass="31549" checksum="812B2D14B85234B8" modified="2021-09-29" version="1">MSQSPAAVAPKERYVPNALKFAFGGLAGMAATCVVQPLDLIKTRMQLSGGSRTSFAVAGEIVAREGFVALYTGLSAGLLRQATYTTTRLGVYNYLFDAYKEKNAGAAPGFGTKTLLGVAAGSVGAFVGTPAEVALIRMTADGRLPVEQRRNYKNVADALIRIVREEGVLKLWRGATPTVGRAMVVNAAQLSTYSQAREMFVGYVPDGITLHFCASMVSGLITTIASMPVDIIKTRIQNAAKGQSQIGVVTSLLKNEGVLSLWKGFLPYYARLGPHTVLTFIFLEQFNAAYFRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G301</accession>
    <name>A0A835G301_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_013663</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000694">
        <property type="protein sequence ID" value="KAF9405709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G301"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF84">
        <property type="entry name" value="CYTOCHROME P450 28A5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9405709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="562" mass="65117" checksum="41E09572FE599EED" modified="2021-09-29" version="1">MSVVNPVAKILSGWSLLYIFINRRTEAPAVANNSVADMNGLIVLASLVFVIFSLIYYLSRKKLGYWKKKNVPHADPLPILGNYGNYILQKEYPGQMIQKLCLKFKNEPYFGAYYGTEPVLIVKDPEIIKHVLTKDFYYANGRESSNYSNGEIITQNLFFSAGDNWKVVRQNLTPLFSSLKMKNMFYLIEKCTIGFEDMLDDEIKMSNVVEVRKTASKYTMDCICSCAFGVESNTMTQKENNPFQLMADEIFESSRYRGFKIIFRAVWPSIFYRIGLKIFPSTIDRFFFKLLTGVFESRDYKPSPRNDFVDLLLNLKKEDHITGDSISNVKTGNEKKVQLKVDDELLVAQCILFFSAGFETSATTMSFTLYELAKHPEVQKKAAEEVDEFMRRHKNKLVYDCVTELPYLEACMYETLRKYPVLGNLTREVMDDYVLPTGLKLDVGVRIHVPVYHMHNNPEFFPEPHKYKPERFLPENKEQVNPNTFFPFGSGPRLCIGMRFAKMQVMSGLITFLKKYKVELSEGMEEELVFDPKTFLTQPLTNCIALKMTEREGWEQRRFVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G326</accession>
    <name>A0A835G326_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Putative inorganic phosphate cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HF086_013494</name>
        <name evidence="15" type="ORF">HW555_012659</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May be an inorganic phosphate cotransporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000490">
        <property type="protein sequence ID" value="KAF9407255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000792">
        <property type="protein sequence ID" value="KAH9630955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G326"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000144">
        <property type="entry name" value="Picot, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9407255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9630955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="473" mass="52980" checksum="6864509F975C4B67" modified="2021-09-29" version="1">MGVVDEKEAVRPKGLGIRHVQTVLLFLGMLFAFTMRVNMSMAIVDMTDERKEFYFPWSHSVQAVILSSFFWGYVVLQVPAGELARRFGGKVLFTIAVFVNSILSLMLPLGAAWGGWRLVCTCRVLQGLTQAFIYPSTHHLVSQWMPLQEKGILTTIVYAGGQLGIALQLLASGFLATSWGWQAIFYANGTLGTLWVILYLIFGADSPESSRFIKEEEVLYIQTSLGRVGEQKRYPTPWKKILTSLPFWSVIVAHCGQNWGFFTLMTEMPTYMAKVLNVDLKNNGVLSSLPYLSMYLLSFVMGFMTDVIIKNSWLSVSNTRKLFNSIGLWGPAIALIGLSYAPEGNMVFAVAMLTLAVGINAGQYTGYMLVHIDLAPNFSACLMGITNFLANIISIIAPLVCGFIVHDETEPAEWRKVFFVASGVYFFTNLFFILFGTSVRQPWNEPKETDIEMKAPEMKEPEKSRLEAKWSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G374</accession>
    <name>A0A835G374_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PTS EIIC type-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001015">
        <property type="protein sequence ID" value="KAF9404328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G374"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901264">
        <property type="term" value="P:carbohydrate derivative transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051088">
        <property type="entry name" value="PTS_Sugar-EIIC/EIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33989">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33989:SF4">
        <property type="entry name" value="PTS SYSTEM N,N'-DIACETYLCHITOBIOSE-SPECIFIC EIIC COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="36729" checksum="912A7367BBC1F24F" modified="2021-09-29" version="1">MPQIIQTYTLEKAVTEFPAQTVVTASNDVEAFASQYTGGSGLFVAIIVGYVTAALYGFLIRKNLTIKMPDTVPSNVSESLSPAILSGVILAFFFLIRVLFSFTPFDNIFTFITTLIQAPLQSLTGSPIAIILIFTLANMLWFFGIHPNMVYGVVMPVMTANMLANMTAFQQHQELPYLAMSIVSYVCGNSFGGQGSTYGLVISMFTAKSERYKQLFKLAGPPVIFNVNEPLIFGMPLMLNPFFFVPMVASPLLMGGIAWGMLSILDFSKYNPLIALPWTTPAPITMALKGGFNYLLIFIVLLIVNVLVWFPFFKMADKKEYVLEQENAKGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Q1</accession>
    <name>A0A835G4Q1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000572">
        <property type="protein sequence ID" value="KAF9406600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Q1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="37257" checksum="EB4D80B7920BBD7A" modified="2021-09-29" version="1" fragment="single">MISTCYRIFTGIKARYLHRLYQNWQIDQPDDPLPRVVDRVTSRPAHPHPSHTSPGGKFYAPFDSVLLVLASGIGGGVRDARASWGGVSCAGVPRWSHSAPAHQADYDNTPAHTHPVFLHDDHINSRFAIWQGDISSLEVDAITNTTDETLTECNAINERILQVAGPELKEEIITRGYECRTGEVVVTPGFGLRCRHIIHTVSPKYVPKYHTAAETSLHNCYRNVLCKATEIGARSLALCLISGTRTQFPPDLAAHVALRTIRRHLESHRMPSLVVLWSWCGPDVALWSALAPLYFPRSAREADAARWRLPHDAPTHDRRIRIIHNPHSHNSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G562</accession>
    <name>A0A835G562_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000520">
        <property type="protein sequence ID" value="KAF9407003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G562"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="45756" checksum="5CE25B493EED29D2" modified="2021-09-29" version="1">MRYSAASVPLPEDPFQKYPFSIPFVRPCLFDDIEMGLLLSVVISYAGAHEAMECLKHILSGVIPDSQPDFQELVEYYSSQLKKAANTSSTGDWSKECGQGYLYLTEDKNGKLKSAAVKYYGDNTNSTAILFSTKISSFGQESLEESQSNGDTKSDRYIPTKTKTILTNTSGSISVGQRNRSPTPTTRETISDSNHNSFTSNSVAPEAKEEDGADEKLTWHYRPLSPTRTPPTLPEIHFQSFDEDKRGVYSEDFLRSLDGIKFRPLQRSDPSGRRRSFKKRHSSSSNSSRESRASREEELKMFTSLEEAEFERMNKDDQVGEFGSTPNLSARSYSRSRSRENSRERRSDHWSVDASLDSAASEDNAELKPMLKDVPKLNSFEEETTETKEVIEEEEDNVDFWGSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5A9</accession>
    <name>A0A835G5A9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Sgf11</name>
        <name evidence="13" type="ORF">HW555_013475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000654">
        <property type="protein sequence ID" value="KAF9405998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5A9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000118">
        <property type="entry name" value="Ataxin-7-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03047">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCA7" evidence="12">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SGF11-type" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9405998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="308" mass="34637" checksum="5C35273784488A1F" modified="2021-09-29" version="1">MKMNTITSELSMHDLNVRFFEIMQNENNAEAAANYIYEAVCDDVTLGFAFEFHHGLKTGLTELMEGEKEEEEPYKIVSTPECDVFGFSMMKKTPDSNCSCPNCERPVSATRFAPHLEKCMGMGRNSSRIASRRIASNSREPTSYAGLLSDDEDDVDWSGGSMQNERRKRRIKNNNNRKPSKVHKHNNGTQNSDSNDGATYETMSANEKKNLLQQICGVVSEHTKKLCTRSTRCPQHTEEQRRALRNSVLEPSTPESQTMGLTAEEAGSPPDSSPSSSCSSSSRKRDRHRAQPKTKSKRERNISPNTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5C2</accession>
    <name>A0A835G5C2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000623">
        <property type="protein sequence ID" value="KAF9406232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5C2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="234" mass="26476" checksum="F852D6B7FF862818" modified="2021-09-29" version="1">MKSPVSFKVTRKSYNNLVLRTIKLPSKIFANHRQRHRSSCARRANFGPRPPRRRKHREVVPEADYVITVEADVILGNSLKTLIKKRSSVKSKLTIYNNYLTLIKSSAAISQLQRLDLEERFIKFQSLHNEFDDLQTQIEVLADDAESTFTEREDFDRQFFSLVALTRSLLGSSSNGVGSEAGFKDADSGGGDAPAESIKLTAARTPSFFLHTHSADQRQRLRAFLCYRAAPVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G674</accession>
    <name>A0A835G674_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_012637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000488">
        <property type="protein sequence ID" value="KAF9407280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001370">
        <property type="entry name" value="p-GlycoProtein related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="84"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="438"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="755"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1078"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9407280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1334" mass="145763" checksum="695C3DAC0C8CDC99" modified="2021-09-29" version="1">MKRDDSNKSFTKYSSQRRLSGGQTSYALGGWRQNSLTISTLAQNSAYLADKLLHEEKEEKARSEPVSWYQLYRYATPCELFLLLIGVFFACINGLFVPLGVIIYGEFTALLIDRTVMNGTSTETLTIVLFGGGKILTNATREENRVALIEDSQAFGIGCTVFSIGQFIVGLISVDIFNHVALNQVDRLKAMFLRSVLRQDISWYDLNTTMNFATKVSDDIEKFREGIAEKVPIFIYLVMSFVTSVIISFIYGWELTLVLLSCTPVVIATTAVVAKVQSSLTSQELKAYSIAGVIAEEVLASIRTVVAFGGEKKEIARYSERLEPAKKMGMKKGAFAGIGSGVMWFIIYATYALAFWYGVGLILDSRGEEKPLYTPAVLMIVFFSVLQGAQNVGLTAPHMEAITTARASAASVYAVINRKPEIDIFSDDGERPELKGDIAFKDVHFRYPARKDVLVLNGLSLTIEENQTVALVGPSGCGKSTVLQLIQRMYDPDSGKVMASGNDLRNMNVRHYRNHIAVVGQEPVLFAGSIKENIRMSNPDATDAEIIEAAKAGHCHDFIKKLPDAYDTMIGERGAQLSGGQKQRIAIARALVRKPKILLLDEATSALDSASEAKVQKALDAAAAGRTTIMVSHRLSTVLNADRIVFLDKGEVVEEGTYIELIAKKGRFYQLAAENQVETEEITTPASTDKVPSKHAKIQKPKRVKSIDSLESHESSVSSVSSDGSVQEEEKEEPEYNPTTWEILKLCAPEKWLMVAGVFAAVAVGSSFPTFAILFGETYGFLESPDSDWVRGQSNIIAILFLLVGVYTGIGIFFQILIFNITGVRLTARLRVAAFETMLKQEIGWFDDPKNGVGALTARLAADAAAVQGATGTRIGALMQASATIVIGIILSMYFTWKMTLVSLISVPMVIGSVVMEGRILSVGLALVREASYKATTIATEAISNIKTVCAFCGEEGVMKRYHDAFVGGRLAARKSLRWRGSVFSFGQTAPVAGYALSLWYGGVLVADGEIHYKSVIKVSEALIFGAWMMGQALAFAPNFGAAVSAAGRVMTLLARKPRVVDTNAPCVPIDYVAKGRIEYTNVKFRYPTRREVEVLRGLSLLIPYGKRVAFVGPSGCGKSTLIQLLQRLYDPDEGIVYLDDYNIVSEMRLATLRGNIGIVSQEPVLFDRTIAENIAYGDNRRNVTIEEIVSAAKQANVHAFISALPNGYNTRIGARASQLSGGQKQRIAIARALVRNPRVLLLDEATSALDTHSEKIVQEALDRASEGRTSLIIAHRLATIQTADMIVVITKGVVAEKGTHKELIAKNGVYARLYELQCGIPEEVDEAAEEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6G8</accession>
    <name>A0A835G6G8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000283">
        <property type="protein sequence ID" value="KAF9410010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6G8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="229"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9410010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="430" mass="48409" checksum="671A12065DFFD312" modified="2021-09-29" version="1">MVFWEIISDEHGIDPTGAYHGDSDLQLERINVYYNEASGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLSTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEDAEFDEEQEQEIEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G726</accession>
    <name>A0A835G726_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000421">
        <property type="protein sequence ID" value="KAF9407941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G726"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="50509" checksum="FE984D3762603177" modified="2021-09-29" version="1">MSAPLLRQTWTMSAVLINMFGQGLVLSFPSSLLPALSQPDSPIKADLHTASWLGSIVGVAGIPGFFISSFLMEMFGRKITHALVILPAIMGWIMIYFCQDITVLMIRKISRRTNASVCMGAMFIHIISGFLHWRTIALVAVTPLLFAFFVVCTWPESPAWLLSKQQYDKSERAFYWLRGNNEASRREIADTIKAQRERMTKPKLTLSYWEQTKDFLKKFTQKDFVKPVIITLLATIVLEMSGRHIFPAYLLHIMSEMTGEKSQSFYYTLGSDVIITASALFASILVKMMNRRTLLFSTGFAAFGVLMAVCTYLFLEAEGIIPRGRSWIPMSLLIVYFVLANLGCAPIPLALVGEVFPLSHRGAGLALSGVWISLGLIVGLKSTPHLIDSIKVYGFFAVYGIIMAVSLVILYFIMPETKDKTLQEIENYFNYGRFTNVDDDDEEANTKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7A0</accession>
    <name>A0A835G7A0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000263">
        <property type="protein sequence ID" value="KAF9410432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF98">
        <property type="entry name" value="CUTICULAR PROTEIN 56F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032762065" description="Cuticular protein RR-2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="53314" checksum="E00BF90C7741675B" modified="2021-09-29" version="1">MILYIFLLTALAWPSSRCEPPVNSYLPPSGSGSRPSSQYGPPGSNGGPSGGSQPGGGLSPSGQDSYSNGQTGPSIDTQYGPPSSRGNGQGPQGFGSQQGPGNFQGGPPDSQYGPPGRGNGQGPNGRGPGGRGGPGGSNGGRGRPQSSYGPPGAQGGSNGGGPGFGQRPDSSYGPPPTGDFQSSANGQSGNQRQGSQSGPDSSYLAPSAGSQGSAGAGGFNGNGGQPSSSYGVPGFGSGPGGSGGPGGRGNGRGSNYDDGQSNEPAKYEFSYEVDDAQTGTKFGHSEQRDGDLATGEYNVVLPDGRRQVVEYEAGLQGYMPQIRYEGGGNGGSGNGFGRGGAGGQGGAQGGGQGYPQGGPGGNFPGGDNGYPSSGQDQSGSLGRYQEGGFGQGDSGSQGFMGYPSGRPGGNGRNGNGRGPSQGGQSGSQFPSGSSIEDLNGGGQGNGYPSGGPQGGRGFPGGAAGGNGGFPGGASGGNGGYPSGGPSGGNAGYPNGGPGGNSGGFPGGNGNNGNGYPSGPQGGRGGPGGQNGGRGRGGSQNGGNGEEGYPSGGPSGPRGSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G873</accession>
    <name>A0A835G873_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000313">
        <property type="protein sequence ID" value="KAF9409511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G873"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9409511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="607" mass="68931" checksum="A38FA4A7709AC97B" modified="2021-09-29" version="1">MDTKNDVRADEIELSAQGSSNKVGEVSTKSDLPERGSWGSKLDFILSVIGLAIGLGNVWRFPYLCYKNGGGAFLIPYFLTLFLAGIPMFFMELAMGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAIFYFFMSMRSDVPWRTCDNYWNTATCVNPYDRKNLTCWSTMDMTTFCTLNGKNISKAVLSDPVKEFWERRALQISSGIEHIGNIRWELAGTLLLVWVLCYFCIWKGVRWTGKVVYFTALFPYFLLTVLLIRGITLPGAMQGIKFYVMPNMSKLMESEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVVGFMAHEQQRPVAEVAASGPGLAFLAYPSAVLQLPGAPLWSCLFFFMLLLIGLDSQFCTMEGFITAVIDEWPKLLRRRKEIFIAITCVISYLVGLSCISEGGMYVFQILDSYAVSGFCLLFLIFFECVSISWAFGVNRFYDGIKEMIGYYPTIWWKFCWVGFTPAICISVFIFNLVQWKPIKYMNYEYPWWSHAFGWFTALSSMLCIPGYMVYLWRVTPGTWQEKFNKIVRIPEDVPSLRTKMQAEEQAKHCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8J5</accession>
    <name>A0A835G8J5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000219">
        <property type="protein sequence ID" value="KAF9411619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8J5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30592" checksum="F11C8169FCC96507" modified="2021-09-29" version="1">MYRESNVYTLGTIGNHRVVTTKLPSVGRTREAMTAAGNTTTRLLGIFQKVEYVFLVGVGGGVPHYTDYARHVRLGDVVVSSPAPDLPDKYVYIFCEKAEKNAKGGWDYEVKPYKPADFLLQDIALRLSNAKPLWDAFVREGLERLRGVPGRWEAPEGATDRLCVDIGEGAFIEVSHPAPQGDQVDRAGGGLRVHLSPVAGGRAVSGSGEARAAFAAHARALAYDCELDAVLDSVVGNRKDCFVSIRGISDYRDGTRGKDWQPHAALAAAAVMKAIVAAMPPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Z3</accession>
    <name>A0A835G8Z3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000264">
        <property type="protein sequence ID" value="KAF9410413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Z3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="785" mass="87786" checksum="687F029FB04D9364" modified="2021-09-29" version="1">MFKNYKDLCDVVSLLVYCPSERCYLFTKEASGETWLPSSKCEKNCWKMTANKIYFELFGIDAGTNCHPLRVYKIWLPSHSLNCVYHAVYKVAIKIDVKKRLKYKPGMRNRLQWLNISELERQKAHLNLRSPELIAFVLMINSELKDSDKDWDVESGSLIEICEENVVIGQDVAGGAVAMASPNLQLLQTAGYTREDQIRMYREFVLMVYPAIYMSINIFSQFMIDLGWQRTQCQNLFRAADVTGRGGLSFLELMLWAAALEPATQHTGMPAEIRCRYIFRYFDSNRDLKLEYVEFKELVAAARAARQLPIDALSVARDADVCLRQLGMQPNSQLPIAEFLRGVGELRLRGTSSLLRAPRSISAYIVDLQEREKEMSQPSTSTKMKMQTGTAALALQDSGTARASPGRRAPCPDYSVAVYTVRMRRRPPNELLELNNFDGKSQDAVSPSTAHLMVNAVHSFDVLGPSCTPVEALAAVHYFASNVERPHRRPSGGSSLNMVKPAWTWTSPAEEATLGSLLLRLAEAVQPICANEPRLLRLSSPVYAVGDLHGNLSALLTMEAALWPSGPALAAARILFLGDYVDRGPHGTELMAYLLAAKLQRPEAVLMVRGNHETRDIQKMFTFYNECLAKYGENEGQKVWNAINNVFDVLPLAAVIDDKVFCCHGGIPPPWVCPLISAIDKVPVPLTRPAEQSSIAWELLWNDPVKPNKITATLQLELTSNEGFAANTKRGTGHVFDQTALDHFLMANQLSHVVRAHEMHQNGFMCQLRGRLVSVFSSFHYCGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G966</accession>
    <name>A0A835G966_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G966"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020339">
        <property type="entry name" value="C20orf85-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14945">
        <property type="entry name" value="LLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14806" checksum="5629B741C698971F" modified="2021-09-29" version="1">MGTEHKVVKYDPNTEAFQMRAQWKKQENCRQQWFERWSWLLEERKQALAQADAIRQEASAATRSQIAIKPDEGKSLKPVPLTSTGVIGWLASRPDCRLEIYTSWCAKPRLRLPDAWDDPNYMGKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9P9</accession>
    <name>A0A835G9P9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_009194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="463"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="716"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9412251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="974" mass="109462" checksum="9C2E0E16F53B2F65" modified="2021-09-29" version="1">MLGGVKLKVIFTHEKTCFAYISPKYSTNNEQTQCVQVLCREKQILLWVVFNSGVSEGHIACNPIYSRMVGLEEGAEVFVSPYSDLKVLDELYVETDSPDDQEILEHNVELLQMRILDQLRLVVSNQKTVVWISASLPVVFTPKQTGILVNHSQIIVKMDAFNSLHNYPSLPVPPPKENEEFKNIGVINKGMLAPYLNAPTKLVLRAVPIDSDGKKNLIHPYTVFIHEDIIEEKYKNLTIILSTMSSIPSILSNDDDSENNNTPINDVGVEIVPIDSVIYRSLCREVHNRNIPTVLIPKSLNAIINIENGMRIIFSIIGDSIDQPDHIDIVTYSDQQQTEMDIVEKFKNCVISSTHSGKKFLINNGLIKQNTEICSGYLQFKLKPEKMKFTMLNSESFRACSIAAKCLSDMDMALPKSLISKLDYDYKYYCRTMKSMEDLVQKVLAHLNFEIHREATFKGVSEIKSNVLVTGLSGTGKSSFCQIIQKELTVWTHILHCRSLRGRKDVSEVLGKAILMCQEHSPAVLICDDVDALVPPNVEGASPQDIAYYQRLAVVIKHLLQTCAGVCVLMTALSTKDLHPTLRQFSGKPLFTAQFDIPELEKSERIELFKHLLTDKIRQEFEVEDDDVIKLAMDTAGSSVREITDYLNKKIFKAVKKKKANPDVPKPRLVEDITKDEEKANEFDIWGPVGGLEEVKQELTECIFWPIMYPALFPSQSCGILLYGPPGTGKSHIGSCLARLANMNMITVKGPELLSKYIGQSEKAVRDIFDKADMKRPCILFFDEFDSLAPKRGHDSTGVTDRVVNQLLSRLDGAEGGARGPVLAATSRPDLVDPALLRAGRLQRHVYCALPDRQGRYEVLRTLTKSVQVDDAVDLQDLAERTEGYSPADLKSILVTAQLTRLENQLATNEEKSMESVVVYKEDIESALTETKPSLSVQQRLFYDMIYKRFRGESLTPEQKMLSSFQGKQRVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9T5</accession>
    <name>A0A835G9T5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000296">
        <property type="protein sequence ID" value="KAF9409817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1419" mass="162211" checksum="DBD36EB6DAA76B13" modified="2021-09-29" version="1">MSLNPLNELKRRLDDEKTPLPKRLCLAKNVVQSHHFPTAPKERIVAEWLCTLTSRNKLSSEELKSVLNWLSVVDDLTSELKSKLIQIVSEFTQRNPLQAEEIQYISTFLENPKIAPQLGLQTDEYLTITVTLLQHLKNDNNMQTSQKILNNFIKYYRESKKKLDFITKLLNGENLETIFSFLDTDCRKTAIDVCQNVLFPINKKSYFISFLQTLIRKDNLDELIAEKGDNIQSVIKIMNTFFEFPKNRSENDTKFLHNFIDVFVSSFQKENQIIFAFYIMVANVLNMEQSFIVPAMNLPSILQDDAKTKRVLFLNMLEVLLRNEIDINVRLTDTFGAKISKVEIKKNFTSFLQALMMGQLKLEGKLDKTTLQIIKTALKLDPVLIEQKIDTILPPIMTAKKNSTSLLESYIETINCLLEILFKLSRGTTFLNQILPSVKKILEDDNTEQFELKQKVLEAKQNGVDCEKMEGKIILGSDLFPQECVTLYGKLTSELMFRQNKELLELLQKDFEVHCLMMLEEGFVSPSIITITEVLSAILSSFLLQNKMADHTVPLNVAEGFWNMYSKFETECLAKFGMCVLKLSYNPPLVISFLKLCQSFAQLKLLNIKYSNVKLDLSPGSNTSEVFDLSMLLPCLNSQQWTALAQKIQDDEAVIFLDNLLLAKTLALQLLSISNQQEYPTITSTKTHLIKQINANPTLLKDTYFCKALFTGLEKAHVKTLAKCLIKLCLDNYDLDVLTIDAVSNNRELLNMLVLETAKNIVKTFENGDSFSKLLGKSDFNIISYAKEVSLVEYFNDISINPEMQDTLKNSINIFKQLPIHNLEENYQLVAIFVMLAIKKCSTVKKLKRSVDYVLQSIYELSLQRPDLYQLFPADNIFNFKDNTLLELLTLKIKTPNTLLIIKSLLELAVKKVRIDSDQVKNIVEKLLKKNKKSNSDIEAFNDPVFQITCLILPSIVKQKKAITASAFRSILADLQEKLHKSLLESFKNIDFGNSSFSLNDTGNTEDSVVQSESSVATLNAMVAYSLTLSRYSENADGEDAKNLDCLLTALEFFVQNAIKTIENADSKPQHIDSAIQLLNVVLRRMKKLETHSIFQEKDKLFLQMWRSIKARLLLEQEKKVISGSSYEEIGTTLKLLCELSSVECYVTNFVGDLNNLVVLKKPSQQKDNSAEIKSRKVFKFLWSQCLKANIVGPKCVAMSKLMCRTCKNLRNWIRQHYDFEDSVARINEDIPTEDLIVKVIKVDDDICEIVRLDLDALSELLLAAKKISLDYSFVDVTFEVQHLIHYVLSTKTNLKFDISWEAFFMLFEGCVTVLNNMLLAREEVLEDRISQSISKRKKHVSRIAAYTVADLCTSLERNAPTKMVRQHLENSVALLIQACDSTYAMSFLKRGLVGYVGQMTMTNLYTMYKRYHKYMGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB49</accession>
    <name>A0A835GB49_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_009456</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="410"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="1232"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="724"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9411851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2147" mass="242075" checksum="ED2BB4A85C0A34FC" modified="2021-09-29" version="1">MINSNLVLQADVRLIERRGRDEATGEVLSLSGKLGGTRMGDRAQRTKPDKTEERKVKRQKRDEASYELSKSKTSRVAWADDTPGVLYRPRAQHTRHAYEMLLTFMQSALGDQPRDILCGACKKITDFNISSSAEGNSEIDETYGINVQFEESSEEDDEDAYGEVREEDKEDGEGSENEKEKDSSADEDSDAEGKRNAIHANLTEEQSNKRRDMTLHPMDIDAYWLQRRLSRHFPDAMVSQAKSSEVLTALGEAADDRDLENRLSESERAAIREEMSKQPHLQKILAQLETGKGDDETSLQSSEAPRKRHKTDPESTSSTGQVTGNRKVLQLEELMFAAGAHFMANKRCQLPPGSFRKQRKGYEEVHVPALKPKPFDEGETLLPIEKLPKYAQPAFEGFKTLNRIQSRICKAALETDENLLVCAPTGAGKTNVALLCLLRELGKHVNDDGSVNVHDFKMIYVAPMRSLVQEMVGTFTKRLSAYNLRVSELTGDHQLTREQIDATQLIVCTPEKWDIITRKGGERSFTNLVRLIIIDEVHLLHDERGPVLEALVARTLRTVEQTQEEVRLVGLSATLPNYTDVAAFLRVKPEHGLFYFDNSFRPVALEQQYIGVTEKKALKRFQVMNDIVYEKTMEHAGRNQILVFVHSRKETGKTARAIRDMCLEKDTLGQFLREGSASMEVLRTEAEQVKNPELRELLPYGFAIHHAGMSRVDRTLVEDFLGREPASSHGHSEGHPGVLPREGALGRAGRARRATDAGPRRTPAVRHQGRGYNVIPSGILITNHSELQYYLSLLNQQLPIESQLVSKLPDMLNAEIVLGSVQSVRDAPALYGISQEKFQEDSLLELHRADLVHTAASLLDKAGLIRYERKSGHFQPTELGRIASHFYCTYETMQCYSQLLKPTLGEIELFRVFSLSAEFKHIAVREEEKLELCKLMERVPIPIKESIEEPSAKINVLLQAYISQLKLEGFALMADMVYVTQSACRLLRAIFEIVLHRGWAQLVDKTLALCKMVDRRMWQSMSPLRQFRKMPEEVIKKLEKKNFPWEKLYELGPNEIGELVRAPKLGKMIHKYVHQFPKLELATHIQPITRSTLRVELTITPDFHWDEKIHGQSEAFWILVEDVDSEVVLHHEYFLLKEKYCKDEHHVKLFVPVFEPLPPQYFLRVVSDRWIAAETQLPVSFRHLILPEKNLPPTELLDLQPLPISALRNPKFEELYNDTFPQFNPVQTQVFNAVYNSDENVFVGAPAGAGKSVLAELALLRLLGGAAPGAAPGAGRAVYLLPNDALADIVFADVYHKFSSRFNVKVVQLTGETATDHKLLNKGQIIVTTADKWDILSRRYYQHYSCTVRKSVQSVSLFIVDALQLLGGEEGPVLEVVCSRMRYISSQIGRPIRIVALSLPLADARDVAQWLGCSANTTFNFHPSVRPLPLQLHIQGFNISHAGSRLAAMTKPIYHAVVRHAGSRPAAVFVPSRRAARLLAADLLALAAAQGAPAAFLRARPDMLQPFLKRVNDKVTPPSILILWNIVSLMIMSSVNWQSKFLATDGIDAMVEKFYGTINRIIMNKYQLSSKFFWSFVKSKLPNNETPITVKYNQQISSTGKDTCELFNEYFYSMLKETLAAGVAYLHEGVEAGDRRLVQQLLESGAVTLCVVAAELAWGLAAHVHTVIIADTYVYNGKLHAYEQYPITTVLQMIGRACRPLEDDHSVVVLMCVAHQKTFFTKLLNDCLPLESHLDHRLHDHMNAEIVTKTIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRHLSDHLSELVETTLTDLEQSKCIAIEDDMDVQPLNLGMIASYYYINYTTIELFSLSLTNKTKIRGLLEIISSAAEYSELCIRHREENIIKALAAKVPHKPSSASGPVKYNDPHVKAHVLLQAHLSRMQLPAELQADTALVLAKAIRLIQACVDVVSSSGWLSPAVAAMELAQMVTQAMWAKDSYLRQLPHFTADLVHRCSEKGVETVFDVMELEDNARAKLLQLSPTEMADVARFCNRYPNVELTYEVVNERHLRAGKPVVVEVSLEREDDIAGPVIAPFFPQKREEGWWVVIGDPKTNTLLSIKRVSLARTAKVRLDFVCGAPGRHTYTLYFMSDAYLGADQEYRFTAEVAEAASDSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBJ4</accession>
    <name>A0A835GBJ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000151">
        <property type="protein sequence ID" value="KAF9413776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBJ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032841865" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="11768" checksum="11045F2FFB0D9CA8" modified="2021-09-29" version="1">MACKNLFAAIFVFACFLTCKGEDCEVYDEFGSCTGPCADGKVLYSMGCHQDSMTEQTCRNPVPWSLGVRCDYSRCECHEPMVWDEAAHTCVNIEDCSNQSNVTAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBP6</accession>
    <name>A0A835GBP6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBP6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27737" checksum="918A83865EA93AF5" modified="2021-09-29" version="1">MSQITDIITVHKNVQESLLKRMGDIEAQIQSAGSSKDTVARIAEEFRTFRELVFDMLKLLRSQVTECCRNIDGLEMRNRRKAVIFQGIPEKDKEDCSQVTLQVINAKLGQDFPMSALKVCHRLGVHNKNHHRPILVRFSSVDYKASVWRAKTRLQGTKISVKEFLTRPRQEVFVRARQHFGMRACWTQDGNIFLKASDGSKHRVICMEELSPLLDKYPSVQSVSQKVAGGGAEAHTVSLKSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC46</accession>
    <name>A0A835GC46_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000184">
        <property type="protein sequence ID" value="KAF9412589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC46"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="23539" checksum="D59C1FC474231E0F" modified="2021-09-29" version="1">MSEREGDSNFGAKRGSVTRVFLCSTNCRLLLKISLSCVSAQKWDYSKIYRFATPTRPKMDEGEYDEVRRRQPETPVRRSVQLEGRSTRAREDERRSRSRTRHEGRRGITHHLRSRSRSTREAGGGRLGRSRSRRRESYDDDDLRQKLRLLEDQLLKRNEQRRRDEATTNYVQLVKRGKYTPLLVVMPGAPNTRNRCTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCU6</accession>
    <name>A0A835GCU6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Peptide deformylase</fullName>
            <ecNumber evidence="2 7">3.5.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the formyl group from the N-terminal Met of newly synthesized proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2 7"/>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PEPTIDE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458:SF2">
        <property type="entry name" value="PEPTIDE DEFORMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="130" mass="14754" checksum="E2DE7605EAAD1382" modified="2021-09-29" version="1">MRHTVKQIASVPGHIARLRGMEEVPFTVYINPKLKVVDFTKIIHSEGCESVQGYSADVPRYKAVQVTGFNAEGVEKSQVYRDWSARIAQHEMDHLDGKIYTDIMDRKTLTCSCWEEVNLSKGKLVIPFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD91</accession>
    <name>A0A835GD91_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9412010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD91"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053031">
        <property type="entry name" value="Cuticle_assoc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396:SF25">
        <property type="entry name" value="BOUNDARY ELEMENT ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396">
        <property type="entry name" value="OS03G0264950 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9412010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="167" mass="19384" checksum="65651FA60E30E382" modified="2021-09-29" version="1">MNKDFEDITFTEFKGAYRGRELSAVWENFLRSENRLYALCKLCRKVLKCGSTVNLRYHLERTHDIKVNLSKKKSINKGDAENMEFSNIPHKRTRTKLSSVWQYYSRSSDKNYAQCKLCKNVLSCGGGTTSSLRKHLSSKHDIKSDDKREVYQFIEVGNDDSSSDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDN9</accession>
    <name>A0A835GDN9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDN9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF14">
        <property type="entry name" value="CUTICULAR PROTEIN 66CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="134" mass="15174" checksum="219E76E393D79AEC" modified="2021-09-29" version="1">MVLVVLTIVACAQSRVFYNLRPIRVVHSDLQPAASIVHAEPKHFEHHISEDEHVDYYAYPKYVFKYGVNDFHSGDIKTHHESRDGDVVKGQYTVVEPDGSIRTVDYTADKHNGFNAVVHKTAPISPHEAAHLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDP1</accession>
    <name>A0A835GDP1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_008768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000177">
        <property type="protein sequence ID" value="KAF9412826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDP1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="11">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="12">
        <location>
            <begin position="108"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9412826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="362" mass="40819" checksum="D77B39CB58AC6746" modified="2021-09-29" version="1">MNTVPILLNKAAMRKYEDLEIPCDAILATYVWIDGSGINLRGKDRTFDFVPKIVKDLPIWYFDGGNTDQAKDDNSDTYIFPQVLYHDPFRRGSNILVLSDTYSFNYQPTSTNFRKSCLILCEKGEVEEPWFGFNQEFFLTSVDGRPLGWPPGGFPAPPGPYYCATGANKIVARDLMEAFYRCCLYAGIQINGINPGSTPSQWNFQVGPSPGIKAADDLWMARYILSRLAEEYGSVANFEPQPIPDWPGNGTFVYFSSKDMREDDGILVIERAISKLARRHGAHINEYDANNGGDNVRRLTGKNRMPHINDFTAGVANRACSVRIPRQVSEDKKGYFEDRRPAANADPYRVISILLKTCIFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE59</accession>
    <name>A0A835GE59_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000180">
        <property type="protein sequence ID" value="KAF9412714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE59"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="284" mass="32262" checksum="3D68E0FD6A97082B" modified="2021-09-29" version="1">MNYKLCAKLYQRILNLKLVFNQDKSAYSIDILLSFTGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDASKNMTQEVVTQYYRAPEILMGANHYTAAVDVWSVGCIFGELLGRRILFQAQSPVQQLELITELLGTPSLEDMRHACAGAHVNKLLITWFYLPQMLVFDPMKRISVVDALAHPYLEEGRLRYHSCMCKCCYSAPPAARHYSPDLEPAAPHAFHDAWERKLTSVHQVKEEIHKFIAEQLQTSRVPLCINPQSAAFKSFASYHIVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE78</accession>
    <name>A0A835GE78_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="148" mass="17648" checksum="132633F8060A7150" modified="2021-09-29" version="1">MAMSYHIDKSKLYQKLFESFKKSHTGTKVQNVQKLVNEVWRNYKLQAKTDKELDIIVSKRIEEELQAATKNKSNLLHFFSKIDSGKWSQNTRQRLLPANLQKKHKKYRHFLTLKNRKKIKLKPAMNHKSNAKIMIMQINKEQNLLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEU6</accession>
    <name>A0A835GEU6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000118">
        <property type="protein sequence ID" value="KAF9415096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="141" mass="16784" checksum="A0FF08331BCC4683" modified="2021-09-29" version="1">MVRPAEDSQMEMKAAYKSGEIHDQEPPITLEKIKTKLKESEIFNWEDPTLTEREKKEMNKLFDAVEIMTTSRNRQPSGVQNMFSSLRLVERVVKKQLKEGQISEELANKFNWEKLTTRQRRDNQPTYYLDKSTNMRMFNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEV3</accession>
    <name>A0A835GEV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_006530</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9416007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="27903" checksum="4C763C20154FE072" modified="2021-09-29" version="1">MAGIIDVLVRVPKEQGFFSLWRGNFANVLRYFPTQALNFAFKDKYKALFLTGVNKNTNFWKYFAGNLASGGAAGATSMCFVYPLDFGRTRLAADVGKGKQKREFNGLIDCLLKTLKSDGPLGWYRGFIVSVQGIIIYRATYFGFFDTAKAFFPDPNNTPLLLTWLIAQTVTTFAGFCSYPLDTVRRRMMMQSGIPPEQRQYKSTAHCWAVILKKEGLRAFFKGAFSNVLRGTGGAFVLVLYDYIKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFK7</accession>
    <name>A0A835GFK7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_006157</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="18">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="208"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1038"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9416490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1283" mass="143284" checksum="5383BB49B911723E" modified="2021-09-29" version="1">MNRIKFKVNGVEYSVGCDVTSDVMLLDYLRDHIGLRGTKYMCREGGCGGCVVSACSPSSKPYAINSCLKPVTSCHGWEITTIEGLGNRKKGYHELQTTLAEKNGSQCGYCSPSWVMAMNSLLQANPNITMLEVEKSLSSQTCRCTGYRPILDAFKSFAADAPRQIKLLDIEDLKICTKTGETCNKGNSCEDNEWCFLDQEDSNDVIEIQLKDDRIWFGVQKVKDIFKIFKREGDSSYMLLSGNTARGKYPMVARVYPIDEYPRVIVDISGVQELKGYTLDQNLIVNAGTTLTEFLQILKTVAKEEYFGYLQKIYDHIEKVAHIPVRNASRNTFFSYLFQLKVATIAGNLMMKNQHNGFASDIFLLLEMIGAQVTIQFLKVNMRGCVIRNVMLPPLNDSHRIFTYKIMPRTANAPALVNAGFLYKLTNDNVVQSVRIVFGGLSPKFIRASSTEQFLIGKKLFTNETLTSALKIMQQELVVEENPPDPSVEYKKEAALGLFYKGLLALSPETNLNTRYKSGATNLHDERPVSRAAQVFDTNTTVWPINKPIQKVEALIQCAGEAFYTEDLPNFPDEVYCAFALSTVALGDIVSIDSSKALAYPGVIAVYTAEDIPGINSFTPPDSFLYSANEEILASGTVKYYNQPMAIVVAKSRYIADRAAKLVTATYANVKDPLLDVKQTINNSERSTQFTKIAATDTGTDVVEVIKGFNEVHGQYHYVMETLTTVVKSSDEGLEVYCSTQWMEGVQLMISRALNLSQNQVDVHTRRCGGAYGLKLSRSSQGAIAAALTVQKLNRPCRFIQSLTTNTRALGKRLPACADFEAGVNSTGVIQYINYEIHEDNGYKKNEQFTQLGEGQFNNAYNRARWNYTSYDSITDTAKNTWARAPGTLEHVAMAELVMEQIAYEMNLDPLDVRLANLDSQYANDIKEMVDYLKIHADYPKRREAVNKFNTENRWKKRGLRFALLRWTPVGGINLYINLSVYRGDGSVVITHGAIEMGQGINTKAIQIAAYLLNIPVEKIIVKENNTVIAPNCALSGGSIMNQNVILGVKRACQQLLDRLKPIRDTMDNPTWEELITKAYNSNVDLQAHGFTRTDEAYPFPVYGVTLAEVEVDILTGQSELLRVDLYEDAGQSVSPEIDIGQVEGAFIMGVGYWTSERLIYSPTGELLTDRSWNYHVPLARDIPRDWRVYFRKNSYSADTVFGSKCIGEPPICMAVVVAFALREAIVAARLEAGIPTTQWYQEVGCEVSSDVMLLDYLRLYAAQSTCVAFGTTMYSSRLENIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGA3</accession>
    <name>A0A835GGA3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGA3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="43834" checksum="6D47EE2863AC0209" modified="2021-09-29" version="1">MHDPYSEYTSNDILDDARLDTFSLIRKYGYNCEIHRVYTEDKYILEMHRIPSINENAPVVFLQHGLLSSSAEWVLMTPGRGLAYILSDAGYDVWMGNARGNTYSRRHASLKPTSSAFWKFSWHEIGYYDLPAMIDYVLKETKVPKIQYIGFSQGTTVFWVLMSTRSEYHEKVAAMQALAPVAYIGNIKSPLIKAIAPFTNSLELIFKILGTNEILPNGKINELAGQKLCLEEAITQSICTNILFLICGFNAEQLNTTMLPVVMGHTPAGASTRQLIHFGQLYKSDKFVQFDHGWLTNKRIYGTFKPPAYNLGVIKTPVFLHYADNDWLSTPKDVKKLAAKIPSVVGTFRVPLGKFNHLDFVFAINATELIYSRVLNIMSQFKNQTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHI8</accession>
    <name>A0A835GHI8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF1">
        <property type="entry name" value="STATHMIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="457" mass="52131" checksum="19889345A9855713" modified="2021-09-29" version="1">MGRGLRDAGCSYRPAALPPAWLSFRARVAQSASAATRLRHTLDSQFDHHHADRARSGLGDAVLLPLMPRARIACSSPTVGARQETSRQTEDQATQEGQLLRSAAKRCRRAVSHTKVILAEPVGVPVPRRADSPEKTPSVEEIQEKLKAAEERRRSLEASKMAAIAQKMQKIEEASRIRSEQTNNFIVNTKEALDAKMETHEEKREAYINELRARLKDHLEGVEKTRLTLEQQTMEVYKAIEEKMNTAADKRDENIKKMLERLREHEEQVRKVRAGNHERFQQLESAIQEKLQQAADRRLMLEAEQKEKLRNHNQKLAEVRSAATAKVEEITKDIETKLTAAEQNREKEMQKKLDFVKKEPYRGIVQEIMNSGMIGIILVLLIQSIRSQSGDPRATRGAGPTEQERARRERGRGHRHVRLEALCTPPHHTTTPPRDEPKDSYHNSNMPNYQRHLTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIJ5</accession>
    <name>A0A835GIJ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIJ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000005">
        <property type="entry name" value="Putative A-kinase anchor protein 10 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="226"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="498" mass="57328" checksum="109BA2F9215A2529" modified="2021-09-29" version="1">MFEKSSKLSLSVNDIIYEKKALKYFIQYMESIGKAALIKCLLEIEEFRKHVLSSTNATESGNLSKINRTQSLDLPYKHECKQYKDIKSQKCNWGENNDVFTSKSNTHFNECSTSSCSNLSEHEQSENSKASSESKQLQWDYTEEAVAIFKKYIALEAPYQLDVPDSFRKSVISNICQPEGQIQENCFKPVQEVLISQIENEHYNDFINSPFYIKAQIDILTSGSLNLKDILHNETILFYFTEFLEQESCRVLLEFLMAVMHFRDNLLNGSTTSSDQAQADAISIYEKYFSLQATHPIGFPTETRLRIESDICSEGGPLPTCFDFPYQIVFKTLTHYVKTFLESELYFKYLSEMIHSVDNMWSSHHKSHSDCSSEFSISTQNTLLAMGDPVFRKKKRNLSVPDMTIDSNQLYNADSLWQRNRPDGLNLGRVNSLGRFESKFEPDPDKKDKSVLKKMVSRFVPSNTSKVEEEMAWQIAHMIVKDITDLTMAPPDNEHDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIL3</accession>
    <name>A0A835GIL3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PBZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_006078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9416648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="412" mass="46675" checksum="EF81620EE0D99889" modified="2021-09-29" version="1">MTNSGINAKRPKSECPYAEKCFRLNPIHFREYSHAHYSYTGTGEFPIPSKLSGQRQMYVDQLKMMVHKQIYAYGRNFDSEAGSRNIGSTPSSSRSGECSYNSSQSSRSKEGGSQNTSSSKESVKDSDYRPIVPPTRRAEDYLSVVRPKGNMAAKHDASAPYYVFYTTIKDAKETHNQPYSITFLEILDSSLGELKCSLQINFMVEIGWLLAQYYFAGYSEKKLTILYGEECSELKNINGSLRVVISTANLYLDDWENRTQGLWFSPSCPELPAESMPHEGESPTMFKKSLLRYLNNYHLPNLAFYVDRVKRCNFSHINVFLVASVPGSHFDLDWGMTRVGSLLRQHCCIPPEETKNWPLIAQASSIGSYGKEPKLWLTGDFLHNFTKIKNQSQLLSTPPELKIVYPSLVKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIP7</accession>
    <name>A0A835GIP7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIP7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="75" mass="8148" checksum="84DE5277409CC84A" modified="2021-09-29" version="1">MEIDDGRFCPPKSKNLVPSPVDSGDRLPTEEPCAFGYLDSKGFSSSKVVTLCLPPSGALMKIAPSWVQHDRIPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIU1</accession>
    <name>A0A835GIU1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000084">
        <property type="protein sequence ID" value="KAF9416757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="32264" checksum="ED57C453F1B0A724" modified="2021-09-29" version="1">MYPDNFEGYIVQPDYFTPSIKNYEHSQRFESAQLEYTITGPEQVRPSDFVKELKNSNFKEALVDFFISHWASDEMAPFIGGKIIHINFRKCHSFMVNETNKVISSITEELSCPEHEEADTKIVYHACKINYEANIIIRTIDSDVAAIMLGHMHRLNDESQVWMLTGTGNNLSSLPPCKSELLQQFLRANYICCIWNNAHLKNPTTYEPVNNGWILENDEYHFKWFEGDQLPNYVSESLKTVSEAGEEDDVDNDEFREWSSSDDENENVNINDDNEEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ69</accession>
    <name>A0A835GJ69_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ69"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="295"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="64038" checksum="5220304387DC2407" modified="2021-09-29" version="1">MARRQIPRLEEIDIERLLVDSEIEDFVPSDEDVGDPEYMPVLDSPESRTRNRSESSENETETEAEERPIRRGQGRGRGAARGRSAARGRGAARGRGTARGRGAERGRTGVRRDRGRGRGYNIETETNSTVETSSNGSSVPSSNWTTQEFHPQSPVLLEPAYLPVGCRTQEKDQSLSLDEMIIPFTGSCSIKQYCPGKPNPVGIKAFVLANPNGTVCDFQVYQGQTTFSDYVDTPFGLGEKAVLTLADQLVPGHILYFDRFFTSEKLFDELEKRGIKGTGTIMKNRIPYDVRESIISDNELKSQGRGSFQVLVRNDKRLALTKWCPTNNEMRKRWLRLLKNKCSMLDWYKSQICSKHFEPKFFDSQRKLKENAVPTIFAPSLPKLAVMKSVKPQNKNMKLDTLQLPSNKLVAKKLSAPNKKALTSKSHENEPRYDPPRTRIDRLLNKLTQAELTANIRNSMSRLKEPADLDAFVSDDLKCSPDAPKEAVLWLMVKKQENLNNRLMDLVVQTKKHVEILQNNSEEANVAKRENEHTIESLRYVVKCLQEKHATLEEQIEILTSVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJA8</accession>
    <name>A0A835GJA8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_004627</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000053">
        <property type="protein sequence ID" value="KAF9418579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJA8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="144"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="346"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9418579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="601" mass="68216" checksum="8CA7E68411326B75" modified="2021-09-29" version="1">MPTPDQILMRKIKKREKKKLQLINEKINGDVEEHEEIEPAPELEVQKRRLGDNEKAVPKKKKKNLKQDIEPQQASDSETDNSSDSNTEVENSNENYTVLGSTLSDGILSNQKFSELEGKVCEQTLKSIKDMGYTTMTEIQAKTLPPLLDGKNVVGSARTGSGKTLAFLIPAIELIYKLKFKPRNGTGAIILSPTRELAMQTYGQLMGLMKYHHHTYGLVMGGADRKKEAKKLFNGINILVATPGRLLDHMQNTPDFIYKSCFCVVIDEVDRMLEMGFEDEIKQILRLLQPNRQTILFSATQSKKVEAITTAFFVGDPLYIGVDDHKEQATVESLQQGVLICPLEKRLLVLFTFLKKSRQKKIMVFFSTCNSVKFHNDLFNYIDLPVMSIHGKQEQAKRTTTFFQFCNADTGILLCTDVAARGLDIPAVDWIVQYDPPDDPKDYIHRVGRTARGLRANGHALLFLRPEEYNFLRHLKKAKVILNEFGFSWDKVLDIQQPLEKLILRNSSLNQAARDAYTTYVRAYDSHHLKSIFDIKSLDLTAAAKSFGFAVPPAVDLKVASLQPPQKKKESRFSKSQNAKSNFKQKVKQNKFKRQKNISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJG0</accession>
    <name>A0A835GJG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_004523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJG0"/>
    <dbReference type="OrthoDB" id="10263060at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9418695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="34041" checksum="3224C8C1D0678EB5" modified="2021-09-29" version="1">MLSIPEIATQLIDKTLTNVDEINSRTIFLVGSKSVGKTTLLYSFLEKNDPPRETLVVEYSFGRKSNQKQGIDKTLCHIWEYGGKLETLSNVLQSTPICGKFFFCIMVDLSKIKNIWETLETCIQVMNDVFSTTNNSPELIIIGGKYDLFKNYDSEIKKFICTTLRSIALLNHAHLLFYSSKEPQLLRRAKDMLFNIGFGNCVPIKEKNTNYTKPLFISKDSDNWESMGIPASTIDQVKVRHMSRIPPNAESSISNSHTVSSQMNAHPEAPLDSLVVLKYNELRNMESLDIPIDYLLSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJJ0</accession>
    <name>A0A835GJJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="33729" checksum="63EAAFCA7355576F" modified="2021-09-29" version="1">MKEDGTVEYFNNIIVQPHLRLVTGQGRGYHVACRYRRRDLAHFHLYRPRADRLTNSLADDFSTDHSYEFDEDSGLLPSVSMKIYKGDPEDEQVASNVRIGDILSLVVSLEKQRQFGLLVSECSVRDGLGWAEQSLIADDGCPLDGEIMGQFQYSADRQTAKVSFPAHKFPYTASVYYTCEVKLCDLKHPTDCEPCAHKRRVRREDEGSPATVELFKGLYVNEADSPDNDEVTSEKKEDEICISQRNFAIGICIAGVILMICVIAAIAFILARRRNPKTYSRTGSSLYSGPYTNTGYSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJW7</accession>
    <name>A0A835GJW7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJW7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="359" mass="38882" checksum="1C9F58ACF26C42EE" modified="2021-09-29" version="1">MLPVHYLPPSGYGARSLQASQRLRTCPGAGRGRPGSSKSLSLLGNRPGNVIHQLDAVFTFAPYLFEIARGEIVLGLGYVGVVGSQFALVDLQSSLVVLLHLLSSARLLSCLATSGWSLPSTASRIHSARLHSGSASRTARLLSVAATAGWFSPSVFSRMDSASFSRLAASLYLFWSLKTIRNKGEYIEHSGDIRMVVSRGLLEVLEGLLAEWHGDLVPSLRRVLDDQVVQCAQAGRDLVARVHLLRKVQRRPAPRVARRPAGVAARPPVRPGATRSPGTAVAPGCEASASQPPLTSEFFISRGIYEMNTKLTTVATPRLNVVSSCLHPFVQKTNIQVPTSISCFVIYVCQLVVQLYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK49</accession>
    <name>A0A835GK49_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK49"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="30242" checksum="3FD233804E68A224" modified="2021-09-29" version="1">MSVFDGEIEYRTVYMVDFDAKKKPKKGSNGLPQTMKLDGVISSDGQVIAELFSSKSPRRKAVDDNCLIVGVSRDMLKPKKEKQKHPDVLCPVSREYYKDAVTRFAEDYPKLTKKYMMKDIDSVLIENEIKDLKRTEYLNKYCSRDLPFMSVNLARRARALQTLRLPDDVAIPDTSHRGSFRPPKPEKYAEPPSSMSMKPRYDDSLQKELRRILRVNTGETTYGACHGLLAKVILEKNPFGKPRKEPRYGRWKNPYMFTYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKG1</accession>
    <name>A0A835GKG1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Meiotic nuclear division protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_001627</name>
        <name evidence="12" type="ORF">HW555_003982</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000286">
        <property type="protein sequence ID" value="KAH9640275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKG1"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31398">
        <property type="entry name" value="MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31398:SF0">
        <property type="entry name" value="MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="10">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="11">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="79"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9640275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="206" mass="24192" checksum="7CFE2BF3709E7915" modified="2021-09-29" version="1">MSKKRGLSAEEKKIRMLEIFHNSKDFFQLKELEKIAPKEKGITMQSVKEVVQNLVDDHLVDSEKIGTSIYFWSFPSKAKNAKKRKVQDLQNEVDECAKKLKRTEDLIASESVGRENCEERTMVLATLESLEKREEDLKKELQKYRDSDPEYMAQLKKETQDLKTAANRWTENIYILKSYIKNNFQMENDVIDQSFNIPADLDYIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKT8</accession>
    <name>A0A835GKT8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKT8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="12157" checksum="860C289FD1A4C28C" modified="2021-09-29" version="1">MSIMGGYEIKISYAPYQVNYDHYYIRVSSSHRLKGSKVIISKHLIHPKYQMSHKFDYDVQLLILHRPLHCTKLVSPIRMSSHFGKYITVAGWGYQTEKSSILHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKT9</accession>
    <name>A0A835GKT9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKT9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="414"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="538"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="748" mass="83450" checksum="A565792A677EAEC5" modified="2021-09-29" version="1">MDHPAFAEAGANPGIEIWTIEQFEPVAVPSKSYGKFYNGDSYIVLKTSGQSNATLSYDAHFWLGSKTTQDKKGSAAIWTVTLDDMLGGKAVHHREVQGHESSKFLGYFKPAIRYMEGGNESGFTEVETNAGAEKRLLKLSGCENMRIEEVPADSSSLTKDHCFILEVDHDIFVLMPEGAKATQRRKIISVANQLRDDNHNGRATIEIIDEFSSDEDFDSFFQALGSGSKDEIASDDSGTTYYRDDISAVYLYRVMLGDDFDVVALNKPYKQSHLTSDEVFILDTPCSGVYIWIGAEVSSDVRKAYHDIANKYFEAKNYPSWVNVTKVSEGSECSTFKQYFISWNTVITRSMGPISDSDAGYDSDDAEQTQKVAQYIGKSAAAREYMPDNGEGSLTVTRVGDGADVTEEFTSGCGMLYQSDAYVVKYQYTEEDGEDAYIIYHWIGSKASADDKQAGAELVSQLEEELGDDAAVVKVPQGKEPRHFLSIFKGNLAIVFGGKDTEYKPTNAGGNYEDNSIRLFRVEGTDLSDMRAIQVGETADNLEDDDVYVLELADIVYVWIGNESNDKEKAAVKTFVKMLVGEDKEITTIEQGSEPPEFWETLGGEPEEKSGSGWRNAVNRRVTTPRTLTAVNVSVTKKITFEDLDTEFTQQDLSDDGVYILDTGEELYLWQGKKIPERVKMARSDIIKEYIEDDGLDRTVDNALVVFVKQGEEPGVFRKLFPEWDNDMWDNQTSYEDIKNETKAANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM7</accession>
    <name>A0A835GLM7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLM7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="404" mass="44779" checksum="0AEEAC996E312897" modified="2021-09-29" version="1">MKALSELKRFLKTQTPILVAYASASERTYLSTVASVSVTHRTKMMFSNIVKCNQCNLVVSELLAFIQNKIDVMNEESLVKLCMSSFSSEEIESAKSLLFESQKKRWNGPVGLPHFSDAERNTAQSTAERCESLPRSTCVAEACAAAPGPRASTLAADCVPPLSEPALEHAPAPSIPSMTSNRQAPALVNECARIVTSIGNAPLLQSSPEQSPAMYRVECGTNVNTSLHDSFANVVETAKQWKVEKPNEQWVLVQKKRLKNRFSTLEGKARKSGSDKFKAADIQVPLFINNVAKSTLETDIVDYILEQTRVHVTLQKIKSRVQRQYSSYKMLVPSAKLSLFLDDTLWPEGITIPFHPATPCTAHGHTRPLPSTPPYRSGVGTFHALYYKYALYLDLEQPTWGSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMH9</accession>
    <name>A0A835GMH9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMH9"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="143" mass="16860" checksum="B3A6EE43568F93BF" modified="2021-09-29" version="1">MSLGKILALDKLTNFFNAIRQNGGIRASLFKLYRQDELKDGRLVGEDKYGNKYYENPRYFYGRNRWVEYSDKVHMNYDGSQVSAEWFGWLHYKTDLPPHQDPSRPKYKWMADFTENMSGTTGQYVPYSTTRPKVEPWVPKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPU3</accession>
    <name>A0A835GPU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="332" mass="37621" checksum="620CCC4E724C22EE" modified="2021-09-29" version="1">MNSDEEKSIEVELEEETKAFLKLKKAPMKTTDKTMKLKMAMLVIVLSGYSKTTEGLKRDKNIMDNEIKYNELDEHTLVTDTAIFPYVVAVLKMSRYLSAGALIDENWVLTAADALFLLRESSRMLRVRLGSINYRKGGIVLPIKYVEIHPYFDDSQPIYDLALIRLPEPVRFTPSLRSVRLQKSFKEVDATHFIVTSWPFPISHRDEVTDESDQIKSMELIKHRRILSVTHLHPLDGDDCAEELTTLGINETDSMLCLDTGVMIDPCMRDVGAPVVLNDVLWGIVSSWRPLNCEPDVAGPSFVTLVTAPNVDTWIHDTLDGHKWIDISSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPV3</accession>
    <name>A0A835GPV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="34259" checksum="DAF573450532B993" modified="2021-09-29" version="1" fragment="single">YNLALFDLKVLYEIRLIKLLEQKVGLWNMKALRTKDLEEGQRKNVSKQLFQAYDGILACYNIFKDTQQLYRKYRVDRTSRKIIDKDVQSLFLPLNVMQSTTLCPKYRIKNNVIFPNSVFCVNFPLHYVFTSSLLAFFDFNTVYAIRLIQILRVEVSVWNIHVLCHHDLEIGRNYIYSKLFEAYVNIMNCYNIYEACFQLYILYYIIEVFIHSLVYIQLAIFVLQKDLYNDISSATAITMFVISWLFKNYLWQMKLITEHENFYSDVRTVQDTCTNLLRKTSSGKIGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSM9</accession>
    <name>A0A835GSM9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSM9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="34"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="586"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1139" mass="130033" checksum="4D612D19BC79F3D9" modified="2021-09-29" version="1">MSIGVFVDPYNNWKKGLEVKHKEFSKTLQKCEETPVVETNNGPISGKILKTLIKNVEYYGFMGIPYAAPPVGKLRFMAPVPADPWDETLKATREKPACIQFNNDIKKGQDLGWYGVEDCLYLDVFTPGIDEESRPVIVFIYNEHFQNSYNKSKDYAPDFFIEEDVIVVTLSHRLSAFGFLSLENEMVPGNSGLKDIVEGLEWVRDNIKQFGGNSDRITLMGLEGGAAAIDLLIHSKAKDLFQAAILHSGSSWASAYLQEDVRDRAFKLGELVERTSTNDIQLLNELQNIPAPDLLTKDVHASPDDYFKQTQKSVVAFSPIVEKQPNGLITEYPEDSTENIDIPIMIGSNSREALEPMMQYLIEPRYITFLRKDFPLLLPRRLRFQFDPLKDVYDDASKDVRDFYFKNGEINLKSVPDLLTYMGDASVNYVVDYTARVYSERSEKPVYYYYFDYNSNLNENKNNLMKYSNMEEGTWGTATGDEMCYLFKCPALADEYLKLEKNVPEEKVIQRKMIKMWTNFAKYGNPTPEEDEDLGLKWPAYTVAKKEYLHIDKHMQIKQDLNKKRYEFWDQFIDKWGPMAVNGVISKIAGVEVKSILKNEKYYSFMGIPYAKPPLGKHRFLAPEPHEGWTDVLDAKKERKTCSQMNLPMRPLKKHGFCGQDDCLTLSIYTPKLPSNEELSMPVVVFLYNEHFKVSHNASREYGPDFFVKEGVILVSIQHRIGAFGFLAFNDEKLPGNNGFRDVIMALKWLQQNIHKFGGDPYSITLMGVDGGAAMVDLLLLSPKAKGLFSKAILQSGTAWNPVHMPPNPVDKATALAKQLERTAVTSTNLLEELSSISSMEIATAESMSVDADEGRRIQSGSVPFGPVVEPDHPEAIITSRPENSKIDIDIPVMIGYNSREGIEINERFLRKPQYLTFADRDFLMVFPIKVDYHFQLNTNSYRKAVEEIKEFYFDEAYVKISKPGEYLTYVADVMVLYPIDYALRKYVNESSSPVYYYTFDYSGELNMRKNNVMEEAVTMEGTWGAATGDELCYLFVCKPISKLYKKILEDEDSEELKVIRNMVKLWTNFAKSGNPTPAGSDFVWTPASKEDKDCLVISDELQMKKNLHADRIKFWDDFLAKYKALAVDGVIKDDKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSN8</accession>
    <name>A0A835GSN8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSN8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="385" mass="43396" checksum="E92503A93313F07C" modified="2021-09-29" version="1">MSEERDLIKKRGSFKGRLTAFVTFLDSLKDKVLSSCDVSELQLRMGKMESLYEQYDEVQLRLECIADDIKVHNSERTEFESLYYKALSRAQTILNDRLIDQLNKDLRALESLGEPVKHWDTFLIYHVTQKIDHRTYREWEEFKGRSNPRIKSMLANQSNNSSSIETAPQVCPKCHSNDHTLNNCPQFLALSIDARIKLLPTYKICFNCLRSGHFANKCKKAGCKLCKRRHNTLIHVDYKDNIIANTHSGNSSNNNLSSSSVPSATTDANNVTLSAHIASSQGHTQRDVLLSTALIKLRDHTGCVHVVRSVLDSGSTSSFITERLCKKLNLFTSQVIPLRARALIIPSLLLCASRRGYGCRLVKVCAGFLFVSDQNHSFGVNSLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GST8</accession>
    <name>A0A835GST8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GST8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16890">
        <property type="entry name" value="lyz_i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.530.10:FF:000019">
        <property type="entry name" value="lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF22">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="42"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="91"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="161" mass="17130" checksum="41C8C008477EA17A" modified="2021-09-29" version="1">MARVARSLAASLGENTALDLSSHLVGSPQSQPVTEVCLGCICQAVSGCKQGIQCDGDHCGLFHITWAYWADAGKPTVNGQSPDAPDAYPNCTNDPYCAALTVQGYMRKFAQDCNGDGRVDCYDYMAIHKRGGYGCVGDLPFSYVNVFNQCVAAVANAQQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSW4</accession>
    <name>A0A835GSW4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_001416</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSW4"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000019">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="464"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9423112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="588" mass="67588" checksum="3CED59A3A5984700" modified="2021-09-29" version="1">MRITNVRRGRIIRMGGACAILLLLLFALHKWSTDTDASESESELILESQSAFYKSHRNVYPTLKTELGNFEPRDLHVVKGPGEEGKPYHMPQDRANDIAESESEYGMNIAASNDIAMNRSIPDTRLDECKYWHYPTELPSTSVIIVFHNEGFSVLMRTVHSVIDRSPPNILHEIVLVDDFSDKENLKSNLDNYIKRWKGKVRLIRNTQREGLIRTRSRGAQEATGEVIVFLDAHCEVNLNWLPPLLAPIYRDYRIMTVPVIDGVDHRTFEYRPVYQHGMNYRGIFEWGMLYKENEVPEREASQHKHKSEPYKSPTHAGGLFAINRRYFLEIGAYDPGLLVWGGENFELSFKIWQCGGSIEWVPCSRVGHVYRAFMPYSFGNLAKNRKGSLITINYKRVIETWFDEEHKEYFYTREPMARFLDMGDISEQLALKDRLKCKSFGWFMENVAYDVYDKFPKLPKNIHWGMVKNKATGVCLDTMGKGAPAYIGTASCHGSGNSQLFRLNEAGQLGVGERCVEADVDSVKQAFCRLGTVDGPWSYDEEKNHLIHRLHGYCLTLQPNSRQLGLVPCDPNNTYQKWTIAHNKPNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTD1</accession>
    <name>A0A835GTD1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WIF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WIF" evidence="3">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="21304" checksum="14D5CFE92E0DABC4" modified="2021-09-29" version="1">MYKFHMNNLVSPLSPGLTAELFYVRNGQINEYALNFVVPVPATITDLHFTWQSLTRKPLPYTLHVDVTDPQNAMHPPTVNISNEGFVPTEPQTWRVDLPCTHTVAAEVDIVIFLNVSTGSSSSALRFRRKKICLKEAPRPAVRVDSVPHAPTFAVMAYCWAMSPDDRPTLPQLQIFLRDFHTQLTRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVS3</accession>
    <name>A0A835GVS3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVS3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035275">
        <property type="term" value="F:dibutyl phthalate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF1">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN LUSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032565655" evidence="4">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16460" checksum="AD5E737B06E0F063" modified="2021-09-29" version="1">MQKLINMLLTKIIKFLILVATCEAMTMKQIRNTGKMMRKTCQPKNNVEDEKIDPIAEGVFIDEKEVKCYMACIMKMANTIKNGKLNYDAAIKQADLLLPDDIKEPAKEAITACKKVADAHKDICDASFHITKCIYNHNPGIFYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWW3</accession>
    <name>A0A835KWW3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000666">
        <property type="protein sequence ID" value="KAF9405885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="423" mass="46961" checksum="A5E079731452E3E6" modified="2021-09-29" version="1">MKWRYNVPPIRGEAQRVEMKYEGEPGDRVSSIMVVIWMYTLCHILGKGSTHTLRYAEATFTMLVVMSRTPSIDGMKTLTREIILCMIFLFCGMGQMSKRVTNMAPITLQKLKCSKATCLKMSSQQSAEADQYSVFGVTFVSMKSKIFVFFLDGSNERFTEPDGIRRLGGHSHKYGVMLLGNLNPITVSSEAVGCGERRVGDDTRHAGHFHWALLSAPSFFQPTSVMLAQEKSSDGLSQITLLKMMIMPDTKFVIEPTTRTTCPLKILSSWRINITIEIELDKDPSRTKLCPVTHAQMEINNTGGNRGALRAPAVAGQIQYISKVYKAEPGNTISSVVITHNIPPALVLRTPLGRNSSKVSITSYRGQGINATISTYGREGLIDNSGLHNEIYNLFVPVNLCRVEALRAGYPNLPQIPSRLFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXU5</accession>
    <name>A0A835KXU5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_012527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000470">
        <property type="protein sequence ID" value="KAF9407449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXU5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="293"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="530"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="871"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9407449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1096" mass="125674" checksum="3D43C1BFD7CDCA47" modified="2021-09-29" version="1">MEDARFEEAPIKKITTRYDYRAPRRLDQLDEIGQNLELLGKKIGRRFESKVGPSNLDTISFESEKLKTSHSESSSRRNSDDGGRAEGLRGDGTSSEPPTASVTNFNAWGELNSSTSTTRTELSLSDGGEEQTTKTRRRSHESALPGTPMHQRAPWKSADSLVPESAFGTSLADIMESPANKNMPFGSLDEKKVHLRDDIKSIRSDSSEEKKSKGWRFVRNVTSAAGAFTAKPKEASTTLPGTPQPSFQSKPDSKNSDYGKEDKKPSLPFYPNEKDENIGETNSEGLEPESLLFRDGRRRIDMVLAYEEEDYGVMTENEARKREHRRTFQENLVKEGLELELENKCLSFDEKTWFLKVHIPWKTEMRLAEVIGMKLPTRRFITISVRAWSDEKQAEKDKHWYSKWRRRWKQLYEYEHTRITPEPSFYGAAEERGARREEIFLVKDRHTQFSPAQRSLLVMQILLRAKYDNNETKMGIRRLLNDGTYTACFPLHEGRYEVNLSDGTVTDRRLLYLEWARPAKWYKKQPLWLVRRYFGDKIGLYFCWLGFYTKMLYAPAIVGTLCFLYGLASMDSEDNIPSKEICDTKGPGNTTLCPLCDKACQYQTLSDSCLFAKLTYLFDNPATVFFAIFMSFWATTFLELWKRKQSVLRWEWDMGGVDQDEDPRPEFEASVKTFRTNPVTREKEPYLPNWQKTVKYVASSSAVLFMIAIVMGAVLGTIIYRISMVSVIYGGTGIFIQRHAKIFTTMTAAIINLIIIMILTRIYAKIAVYLTNMENPRTQTEYEDSYTFKIFFFDNVIHHFSQGRFYDYPGDDQARKSEFFKLKGDICDPAGCLSELCIQLAIIMIGKQFVNNFVELGYPYVRVFVDVSMLSVLQYGFVTLFVAAFPLAPLFALLNNIAEIRLDAYKMVTQARRPLAERVEDIGAWYGILKGITYAAVVSNVIFNTSDYQEDWGADENEVDPPVCAYRGYRNPPDHADPYGLSPHYWHVFAARLAFVVVFEHVVFGLTGLMQLFIPDVPSELRTQMQREALLAKEAKYEHGRRRLSTEYRQLLTQKSESGPEKPTGGAWLRRASRASDVLDAHISVSQRPTSPRIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY37</accession>
    <name>A0A835KY37_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000426">
        <property type="protein sequence ID" value="KAF9407884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY37"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21287" checksum="4C2C490D35BF693B" modified="2021-09-29" version="1">MGEPDVDYRCLEDMLPETVARLQLPAHLIYTDGSKSVDGVGAAYSYWRDGTEIRTKRMRLESMCTVFQAELLAIARATDLVVRGGFGCAAVLSDSLWFPHCWWHLVSEQLQQWCWCRSCRSACARSVAPHVRWLRRVGFCRWAAPAPASPLLAAAARFYHVFALAATSTYVLQQLIYAYQASGYNNITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYI6</accession>
    <name>A0A835KYI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000558">
        <property type="protein sequence ID" value="KAF9406709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9406709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="137" mass="14397" checksum="80F62FDEBB320787" modified="2021-09-29" version="1">MIESTIESCPFKSLTSCIIGYGLGAAVGLFTSSLMPNVSVTDPNAMQTQSAREILREMKTSMLSYAKNFAILGAVFSGVECCIESARGKTDWKNGTYAGGVTGGLIGLRGGLRAGIFGAAGFAAFSTVIDYYMHQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZQ8</accession>
    <name>A0A835KZQ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000662">
        <property type="protein sequence ID" value="KAF9405921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032761032" description="PHD-type domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54897" checksum="51F1F2419A0F0135" modified="2021-09-29" version="1">MQVSVTLLNIGTILASLHCLGKQPELKDSGTKSHRRMPEKATCFKCRKSVDIKETALCSICNHRYEFDCDGYPEGTYRLMDTESKKRWKCKTCLKNNKKVQDASNVTNITTRKKGNLRQDCSPPAPVRIQNVNDSKQTVPVMASVQNTLDILDSHILSECEISGGSYDTPNKLSKSVDGTISETLTILEMKDTIKRLTNKLDSTENELENTILENNNLRQQLDKLTTEIKLLKSLCHSSTVTENSPALNPRRKRHSLIHQRSFFSPSTPLPNSLQLDYGKNTEIMELNQKITELQNQLRDAQQQIQACKKIIDESKHTNVTSPNSSVSKINTRTSFHAEEPNHETSNRVLIFGSQQCVGLAAALIHSRRNTREKQRGGTCILIKKGISYKELPFVAKHASVNTFEACGIELTDGKLIIICIYRTPQSDPNQFLTKISSSPNDLENSILPSYTFAKVEAKRVHISAPSVAISVPLDIVTGIQLSPFRLFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0W6</accession>
    <name>A0A835L0W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000425">
        <property type="protein sequence ID" value="KAF9407888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0W6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="68849" checksum="69787054618B398B" modified="2021-09-29" version="1">MWFLLLLLLPGVRLQEDDPPQKDNPYRLPYNSVQFVEHTASKKGPILFPNDAPPPPPTPLIVTSRPLIESIARSELNPNNSIAAQSQYHQVQFRPDYLARSRTYKPYAYGGPSTPVYDYRPQNLGYIVTTVRPDKDNYYKEYEFSQGINSRKGDFDHEVNMKHIKDWHTSLYSRETEDNDQVADHNIENQDEQSLNDLNENFGNDIYQDQEHNTPTPKVANNKYQGESPEILNYDGGRENSKEYNHGDNYAFSYTVKDHKTGDDFSHSQQSTGSATNGEYRVRLPDGRMQIVSYTADENGYKAKVRYDEHTGADNSIDVNVNKGNAYRPPTPITFKPIDHIYNDNLDSFENDDYVRQRFNEQKILKTPLPVQQHASSYNTIPQNLYGPNQNNFQIHNDLRSKHVLDTNKYLNKDRVDDLTDTNNEFLKHYHEKFDGNNKLHRNKGDDYKFSQEISDYSSELGHSNQHHNSKFADFYDNNEGEANGKVTPTYDELKQLFGLDSNSQQNSVSTVRPYDEVTEDVVAITPKKPNLYTNVNLYKNPLTATPSPFPYSPSPTTPSSYLYSTIANLKERITFGHKPVLSHQYLNKINKYLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1G8</accession>
    <name>A0A835L1G8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1G8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032270544" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="122"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="415" mass="48209" checksum="594A81F476F92D57" modified="2021-09-29" version="1">MGLNCVQTLFCLVLVRYVLAERKCCPPGQVLLMRKDVCWEPKTNVTEPVPLKCKMRPIRFIKNYYVNDKNELKLHLGEDFPDETVTDNSYCIGNHTTIRDVNMSNTKAVALVCADQEEEIIDDKILGYTMIVSVIFLVMTILVYSFLPELRDVQGKSIINFCTSLAIGLGVLVIMKLMVYNDMGWCAVRGFLAYFFLIAAFFWSNAISIQVLLNTRRPATVDYGWREFKYYMLYAWGCPIILTVCMAIVNFYPGKHQKPGIGLNHCWFFSKHQQWYYMYSIMFLLLVTNFAIFIYTSLLIWRIPVSSSLKRAVKYKLGMTVQLIILMGLPWVFEMISSLTPKHIIWTILDIINTLQGILIFLLLVVFRKRVIKVMYRHGWLDCIANYIEKYLATEDDEEDVVQHTDIPMNDRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1S8</accession>
    <name>A0A835L1S8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000325">
        <property type="protein sequence ID" value="KAF9409311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1S8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUF659" evidence="6">
        <location>
            <begin position="111"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="471"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="547" mass="62436" checksum="5F2259BE0BE69FCD" modified="2021-09-29" version="1">MYRVPNVTKMGTHLLKCPKCPLVIRNELTESCEETSLIASNTTNSAITEGGYVTSTPSDATPLLEFTEEKKRRLTKLLSKAIYVTGSPLSMVEHPLWREFFKELQPLFELPTRKVVSTTHLDTIYNEMEREITEELKSTNNLHLQCDGWSNRRNEGIINFVIAKPEPVFVKSLATSSHRHTAEYLSEEIQQVMRTYGTYKFVSLIGDNARNLQKAFDLVKLEHPNVITLNCVAHTLNLLCHDIMKEDAIEAFISVAIDVIKSVKKSQILCALFKQIIAEKGSGEQLKLPSKTRWGSYFHAVRSLQNSKAALQCLAVHEDAKMIPADIKAHLLDEEFWKMIDESTAILEPITDYIFKLEGNESYINDVYMAFKDIKSRLVFLLPGFSSLFDDNIRDRILNAVDKRRENCIKPIHLAAYMLDPKCQGIEMNEDEEIIAMDFIHEKGRQLNLEVITDLANYRAREGFWAKSFVWASLQNMKPLTWWKGICKNKALSKVAACLLTAPCTSAATERTFSIHGNIHSLKRNRLTTERAAKLAYISYNWNLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L223</accession>
    <name>A0A835L223_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 69 ARM repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000230">
        <property type="protein sequence ID" value="KAF9411270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L223"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902093">
        <property type="term" value="P:positive regulation of flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048732">
        <property type="entry name" value="CFA69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048733">
        <property type="entry name" value="CFA69_ARM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21049">
        <property type="entry name" value="CFA69_ARM_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 69 ARM repeats" evidence="2">
        <location>
            <begin position="436"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125770" checksum="65DE2D1370A3BA77" modified="2021-09-29" version="1" fragment="single">MSKTGGSRSRLAPNPTEQSVSSDKITESMPMGASSDRLQHSSPKFPSRRSKILRELANDSKESSHTKFYKKTREKKEFEQTTRQEFLSSSESLSGSSDTFGCIHGPQGKEYSAKGLLKRNIVKNLDPIPTDPKWSADCISSLKWAVAQKLEDLVSCPTVEQQIGRLQELLSEFASISSTGYSYQRVDTLGNLCSILKYLLEAVVQFPSLKPELVSLLKNFNGPILLLKASDVVTYFDKIKQFIGFMGYLLIELQDGDLLDVVAAALLWHLSAPDTIRGQATVQLRHSMAAAAPVLLQSTVRMIAIAEPRRFAIFLEIALLLAFDTAENCIEMMKENILENLFYRFNPYFPERKLESYDISPLDCHDPNVKLGESTVNITTTLTILLVLLKTTKDYLDKNPKLGALLPCPDCCAQRCFIWAYRYECRAREHRHERITLTVIAAALIKCFGERLFLFSSVLMADIVSLSVLTELPPRDDWTATVHFTTAQQDVQFKKLLINFVVDLLKTFPYNKFMLQSRYWFVGIMSLIDPGLSSLRAHWSPPLFAELRKTALQALVCTIPLTDPKCVKEYGLIRRIMWYIEWYSENPYEISILYWCVRLLQAAIHLTRKPERDRAIRDLFDTHGIVILIHLCHTLMEQKLPIVEKSQAVLALSLQLLTSSVHVKQKLSCCVYPDIKWPVCVNSLARKMVDVVLYSLDQNFIISDRWLVSLFNFIWEAIIWTPEYRTHFVATDGIYKLLDIITMTRPAVQCIALAVVCDIARAGNAVGHLVSWRANLRASKAVTLESDQELRNPNVVARGATIASLLAAVFREGCRSTGVKLDEYGVLQNLDNPIMSEDVREELQNTDVFYGISHSLPFCLTAQDMAGSCMSKAFALLHMLSEDLHDKVQLADEAYNLYKNIKLAQEDEVILVLCSHYLTLKLNEVWSETKVQCVDMITKDNEILEDFLAVGKGWAKEIKRQQEEVIARDRKKEKEEERSLYAFLSRIRLNIALDALHAVRCVARSTDRARITHAMLQDAVLAHHRRSLLAENNNTTLLRTYKSPLDDQNMTGQNVKVNSICPKHIRKSLELNMGEKIVEKKETLYCLKYGTQTLTELNFIRTYRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3A2</accession>
    <name>A0A835L3A2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM elav family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3A2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000480">
        <property type="entry name" value="Fne, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="117"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="270"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="353" mass="38152" checksum="0C87FAA9C3FCD687" modified="2021-09-29" version="1">MSKGDGEQQNGGGEESKTNLIINYLPQSMTQEEIRSLFSSIGEVESCKLIRNKGAAFPDALNHALHGGGQSLGYAFVNYHRPEDAEKAIATLNGLRLQNKTIKVSYARPSSEAIKGANLYVSGLPKTMTQAELERLFSPYGRIITSRILCENSGGRPFTGGEQGLSKGVGFIRFDQRVEAERAIQELNGTVPKGATEPITVKFANNPSNNGKALAPLAAYLPAALRFPAPLGRFSSGKSLLAINKGLQRYSPLAGELLGGVLPGAVGSEWCIFVYNLAPETEENVLWQLFGPFGAVQSVKVIRDLQTNKCKGYGFITMTNYDEAVVAIQSLNGYTLGNRVLQVSFKTNKIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4F4</accession>
    <name>A0A835L4F4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000126">
        <property type="protein sequence ID" value="KAF9414746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4F4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="196" mass="22507" checksum="C45D9603AC22C9DB" modified="2021-09-29" version="1">MSSILGEFNREQDAFIKGQEGRGSAAAVPPWDRRNFVRAPPAGVEFDFDYDKMYPVAVAIMGEDPNLEKMRFDLVPKVITEENFWRNYFYRMSLICQANEADAAAGRQSSAEDSQDDDKSASDNLIVNEKSSQEMIDDVKQRIKSLKVDRENEDEQWEKELEAELNEYEVVADKAGDDKQWEKECEDLLGDDMDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4I0</accession>
    <name>A0A835L4I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4I0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="38310" checksum="41F89F483430075A" modified="2021-09-29" version="1">MVSVEYVDTEYSLWLTWFLMPVIVTFLLPAVIIVLIYISAIIFHLYRLYRMNVVDGVQPDWKHAARLAVCALWDAHGWLWHGYDIKGLENIPDGPFLVIYYHGALPIDMYYFIARMLLFKRRHIHTVADRFMFKIPGWATLLEGLCVIPGTVQTCASVLRNGNPLAISPGGVYEAQFGDHYYRLNWRNRIGFAKVAQEAKVPIVPMFTQNVREAFRTVGWLRGVWLKIYATFRMPLAPVYGGFPVKLITHLGKPIPYDPELTPEQLQRKVAHAIEDLVEEHQRIPGSILQALLERVHEIPKRRKDPPLTNGKCQNGTLKSTEDSEKSASGKSKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Z8</accession>
    <name>A0A835L4Z8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000307">
        <property type="protein sequence ID" value="KAF9409610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Z8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="445" mass="49452" checksum="A23D5B52A078B784" modified="2021-09-29" version="1">MPLQNARINKLKNISKRLLEDTQDDKEEFKKRPCHGIQNEPVHLESANTPTTHQTSKNHCESTRNEDDVNQNANEDISSHNLGFNIVPSQEITSKDHQKAEQEEPLHVDENLPPNEQLHVERRNSRSSTSSRASPRDFSPASDDDPSYLPLKPSTANRRRSDSSSSSDSSSSNSSSSSSSSSSSSSSSSSSSECSSTRNHQCPSLATLASAAVDKISTIQPTTIRNDCNEDGQGTVTHSLESNNLTSVPGLASVNILNPVVEEGNRNSRKKIRRINKKRAAQIRRNRGQSYVSTSSKIVAERVMRGPCNEKCRLKCRDIIAEDDRRRLFDSFWNLGSLTRQRDYIANNLVNVFPKTASSSSSSLRLTLEGMYTQIARHSTQLVTIGTDDNDRCLACKADWWRAPASSASYIRTPRLPDLAKMPQCRPIMMDVSPNVRISGLIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L554</accession>
    <name>A0A835L554_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L554"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000002">
        <property type="entry name" value="sec1 family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="611" mass="68064" checksum="6202B0096F0EF236" modified="2021-09-29" version="1">MSTLRERQLNALKQMLNLNQPLTKSVATEPTWKVLIYDRVGQDVISPLISVKELRELGVTLHVQLHSDRDPIPEVPAVYFCAPTEENLGRICQDLDNGVYDQYHLNFISPITRQKLEDLAASAIQSNSAVNIHKVYDQYLNFICLEDDLFIMKHQQSDALSYYAINRGDTKDTEMEAIMDNIVESLFSVFVTLGNVPIIRSSKGNAAEMVAKKLDKKLRENLWDARNNLFHGNTGQTGSFSFTRPMLILLDRNIDMATPLHHTWTYQALAHDVLDLSLNRAVVPENQTPTVQDQKTKTRVCDLDSKDPLWSEHKGSPFPTVAEAIQEDLDKYRSSEAEVKKLKSSMGLDGESDLALSMVSDNTQRLTSAVNSLPQLMEKKRLIDMHTTIATAILNSIKSRRLDSFFELEEKIMSKSSGIESKAVMDLISDPSAGTPEDKMRLFIIYYLCTSQIPDDEYKRGFTKMSSQYEGGGTKTVSMFSKLVSQGSSFVMEGVKNLVVKKHKLPVSRTVEAALSGAGSGEGAGELLWLDPRAARTDAAARARSAKHSPPTDAVVFLVGGGNYIEYHNLIDFTKQQATSGTSRKIIYGATTLPNASQFLKQLSLLGEEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5F4</accession>
    <name>A0A835L5F4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000124">
        <property type="protein sequence ID" value="KAF9414808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5F4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="852" mass="95840" checksum="791DECEC3DFFF012" modified="2021-09-29" version="1">MHNLPSDFLMTNDSDLSEHSDSSDFDGTSNCTMDQIKKRKDNWKVFRPKSKKDDNTPTCSSSYTVTENSSREIWKSKTIRQNGETVGLKIRKSYKNKTCKTFDGGDQIETIKSKRASTRCKVIPCLSNTLGQTSNNVKQMSIIRENRAENVNIDTGCQAIRVNGEHKIRKFNRSQQFCAVQPVYAVEGNVHAETTPFQHTKIVREPLSNRKTVGNEKSNDWCLMSSLEDNEHRFLKHEVYERRSEIPNINKYNIKTDASQGFKRHKHAEQPFPTKLNQNFEVYTYPCLNRPETGSSCKTSDQNRSNNELPSTCSGFWDYFFAKLNAQNQNQTNNTSKPCKCNTTSGSFSNVCRSCDKSYCTHDLSQGSQTGTLKKAPICCGPTFQRTNSMQIPSKELPPCLDLFLSKNAPPCQEVPPPKSKPREKVNCKCYPEKKKQKSKTCEGIGPNASAQSIPCPAAAMAGSKDGLRPCQLPHANITETLSQKYNGEILCIHNPPCVLINGCLNLPPAKEEVTMDSWPANTSQSKSCSSPHSTYNPKKPETEYCVQTFQQTPFIIQNSGCQYSSPIIDIRSYNKWRSNEGFQYQNSSTAKPTSVDGSCQYRPSPFELRNHKDVGNDSARTYGISSNEIQKLKSVNESCQYWLSPTEVEKDQNDTSEGCFYYRRTPTEVKKLSTYSKENVKSGGIDLRVSKPRKEKIVQSMCNHSPPCEVVRLCKATNEPILQDPCMHASISKKLPLSLLELKTRNEAVQSYQHRPKCVEVPICMNNSILLSAKEEVATQEHSKCKMVSKHDPPCVIHSCLARTCDSRVPSDAIPDCVHQPMCKMIPACCRNSAKETVSVHTQYPNQCSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5F5</accession>
    <name>A0A835L5F5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_002783</name>
        <name evidence="7" type="ORF">HW555_010650</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000273">
        <property type="protein sequence ID" value="KAF9410213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000294">
        <property type="protein sequence ID" value="KAH9640123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5F5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9640123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="491" mass="54989" checksum="F96E9CF4BC44000B" modified="2021-09-29" version="1">MSYDNIFENLNSHGQGHLLKYWPDLSEKERAQLLSDIKKIDFAEVNELFRRANDTSKVILEKVEDLKPIPDSHYEAVPNLSNEKILEYENIGLKEISDGKVGVLLLAGGQATRLGFGHPKGMYDVGLPSRKTLFQIQAERIVRVQQMAAEKYGKEGKITWYIMTSEHTRGPTADYFRSHSYFGLNEEDIVYFEQGTLPCFDFEGKIFLDEKYHVSSAPDGNGGLYRALKNQGILADIAKRGVEHLHAHSVDNILIKVADPVFIGYCKSKNADCAAKVVQKSTPSEAVGVVCRVNGHYKVVEYSELTDEAAESRTADGRLTFSAGNICNHYFSSEFLTKICNFESKLKLHIAKKKIPYVDHEGVRQKPTEPNGIKMEKFIFDVFEFAENFICLEVARDVEFSALKNNDAAKKDCPSTAREDLLRLHRKYIREAGGIVEDNIDVEISPLLSYGGENLEDLVSGEVFTISPYHLKSMQESAANGNGVNGSNGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5F8</accession>
    <name>A0A835L5F8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000123">
        <property type="protein sequence ID" value="KAF9414832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59554" checksum="84B1964BA93317D8" modified="2021-09-29" version="1">MNTLAEIECVKPSRSCTRSDWWKQFYPLDNSDNSVLRLRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRATAGDTHLGGEDFDNRLVNHLADEFKRKYKKDMRMNPRALRRLRTAAERAKRTLSSSTEATIEIDALYEGIDFYTRVSRARFEELNADLFRGTLEPVEKALKDAKMDKSQIHDVVLVGGSTRIPKVQSLLQNFFCGKKLNLSINPDEAVAYGAAVQAAILSGEQDSKIQDVLLVDVAPLSLGIETAGGVMTKIIERNCKIPCKQSQTFTTYSDNQPAVTIQVYEGERAMTKDNNLLGTFDLTGIPPAPRGVPKIDVTFDLDANGILNVSAKENSTGRSKNIVIKNDKGRLSQAEIERMLAEAEKYKDEDEKQRQRVASRNQLESYVFSVKQALDEAGDKLSEQDKSTARDACDDALKWLDNNTLAEQEEYEHKLKDVQRVCSPVMAKMHGAGAQGAGGMPGGMPGGMPGGMPGGMPGGMPGGMPGGYGGNHNSGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5X3</accession>
    <name>A0A835L5X3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trissin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032727868" description="Trissin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15518" checksum="D6E732BE1DCD002C" modified="2021-09-29" version="1">MFKITAIVSLLLIATWSQADSKRHKKEATASSDFPSGSTLWAASLSCDSCGSECASACGTRHFRSCCFNYLRKKRGPETLKFLAPNQENLKETQPHSKLPMFVVENIPVPEQWISNLLSNENHPYSIDDMVENRMYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L675</accession>
    <name>A0A835L675_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L675"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032928667" description="BEN domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="BEN" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1107" mass="119313" checksum="4D9BA086AD2994F2" modified="2021-09-29" version="1">MVLSARASLTIIMSTLWVLAELENIRNPFTLFDQKVMVRVFRTGHDDNTWTPGRIVNLCEDGVTPVRAKILFVSENRKAVRDKKMRSDVQEKYMTDMLNRCFRTVRSMRNNVETYCLHVEEPPNSSEDGHNLPNLIINRRTGQTSTSNSDSSDSEDEGRISSNLVDDERRRQLANRLAPNPINYRAGSQLYINRPAPQPISNRPVAVPQPVLNGAVHQPIANGAAPQLIGNGAVPQPIVNGAAPQPLVNGPAAPPIYNRPPIPPVIYDLCPPRTIYRYSIQPDQLVVNGPALPPAIDRPASLPVINRPAAPPAVNVPAAQPAQLVVNGPAVPPIANELNPPAIVYGPALSPAIDRPASIPVINRPATPPAINDPAAQPAQLVVNGPAAPPIANELNPLAIANGPALPSAIDRPASLPVINGPAAQPAVNVPAAQPAQLVVNGRAVAPIANELDPPAIANGPAFPRTVDRPAPQPVVTGSAAPPIANGLNPPAIANGPTSPPTVDRPAPLPVVSDSAAHPVVNGPAAQPVIDNPAAQQAPLEINSPAAAPLIVNCLTPPLIVNEPVPVSIANGPAPPPVVNGFATLPIVNDVAPPQVDNGPTHSTSFNKPASTPIVDSPASPPTVNRPAPLLIIDSPASPPIIDRPAHALIVDSPAAPPTVDRPAPLLIVDSPASPPIIDIPAHALIVDRPASPPTVDCPASPPIIDRPAHALIVDSPACLPAVDRPTLTPIVDSPASPPIVERHVPTPIVCSPDFPPIVDQPAPLPIVDSPASPPIVDRPAHTPINETRNDRNNKSDAENTFWKRIRKLKMCASYIEREMLKFLEECGFTTSTEENDEEEAQDDPNPDDEDITTYQLSSKEKDQEMIAQEDIEAIEQNERAQQASLNNLHLEEENRSEDEEIGAEDVEGVDKRNGRRFRLKRKGSQSGLVLNGSRHHRKRRRTLPKISFSNIRRNCNNLILTNNAVFSGPQVEIGTGFAKVPGCVVNSIDWNSYRLATRQLLLSVFPRSVLAQYSLLGSEPTFYMKKPTKRVLNPLLVEDIVRTVASKCDVPKDLVRKCIKANCREEIKIFRKNQRKMKRKRRHLQQYDEDLPSSSSEELVDQEVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6H9</accession>
    <name>A0A835L6H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32488" checksum="115B606B2CC02F94" modified="2021-09-29" version="1">MYLHQSAVSARTRKRTKTQVRNDQSTDTTAEKVNPITVDSTIVEKLVSDNADLRSQIVNLSASVEKLLNQYNSSSCQVSATTTMVTDLPPVLSHGLQSSTPAADTETWATVVRKNNPQRKTQPKAQVASSAIQKKGRTIVLPKVPTTAVIAITIPEGSSATYAEVMFEARQHIQLSQFGIESLKQRIGMTGGMLLEISGADCNAKADKLATRMQEVLADIDVRITRPCKMGEIIILDVDESVSPVDVAIAVAEAGGCSPDDVKVGAIRRQLHSLGRVWVRCPLATVKKLSSSKKFVLGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6U7</accession>
    <name>A0A835L6U7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6U7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032427565" evidence="2">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="398" mass="44117" checksum="0ACDC3F7F68F1631" modified="2021-09-29" version="1">MWPTLLTIIALSVTISQGHDGLHDQNIVKTITGQEINTNRVKRFVTGYFVPQNKTNTPRWDNGTYGYNRNTTQQYVNPVQNYNFSKPGYQPYYPNPPGYTQYPANYSVHPAPNPQPNNNKPINPAYPGYPQYPSNYSGYPTPNPQQNNIKPLFPTQPGYSQNPSNYSGYPAPTQQSNNKPFNPSPYPGNYSAYPVPNPQQSNSKPVFPKPSGYSQYPSNYSGYPVPYPQPTYNINPANYSGSPTQLFPSSPGYAQNPSNYSSYPSPSLQPTNKPFNPTQYPGNYSGYPQPSNINPIYPSLPGYAQYPGNYSGYPAPAQQPTNNIPTSSASWLRPSQNNSTVYPVSNTTKPGYDNPAKNNMCGRNDAMHTDACIMTVSGENCPEGTIRFGNYCVDDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L701</accession>
    <name>A0A835L701_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L701"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="414" mass="46921" checksum="EFA8987DF0543030" modified="2021-09-29" version="1" fragment="single">IDFNDPITDKPANLANSAVLRMLEEEERNRRGGRPKLDPSQEWAIKKNMVHMSHPFDNYWPPDKSRMRSARSWDGQLNATGNVYSEFLKATKGQKKVVWPPVPETNGYHQTPQQQSPAFYNNAQQSPASPQPQQQPQYQQQPQYQQPQPQYQQPQYQQPQPQYQQPQPQYQQQYQQQPQYQQPQYQQQPQYQAPESDPSFCEGRRQEATGLSKLIPVGPGVTASPTSYRPGPPSPGVAQPYRPGQSRWAPVPAPLSPQTQGSQPGYPSQPQLSPSQYSPQPDYGSSRPSYSEPQYQAPQKNYEPPPATITLRQQQPVHQKPPPVFPSQPATASYQGGSNMRGDQKWPPQSVKEAVAAENEARRQLARGPACRPRKVKKDYGPFFAQHALNNNYPGYRAPPGTQHYEDHSGRSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7E1</accession>
    <name>A0A835L7E1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_002012</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9422203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="255" mass="27352" checksum="D3EF473FA486321A" modified="2021-09-29" version="1">MLKGVSLVTGGASGLGKATVERFVKNGGKVVILDVQGTRAQQVAQELGENVVVAKGCVTSETDVKNALDIVKDKFGRLDNLVNCAGQSSTHQIYNFYKDKACEMDDFIKCINVNTIGTFNTIRLAAGLIGKNKPDDNGQRGVIVNTASTIAYEGDIGQAGYAASSAAIVGMTLPIARDLASQGIRVVTIAPGLFDTPLLSYLPEKMIEFLKRMTPFPSRLGKPEEFAQLVTSIVENPMLNGEVIRLDGAQRWFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7M4</accession>
    <name>A0A835L7M4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_014693</name>
        <name evidence="4" type="ORF">HW555_001751</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000750">
        <property type="protein sequence ID" value="KAH9631692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7M4"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9631692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35928" checksum="52ACF112EAAF11CA" modified="2021-09-29" version="1">MALLPPDPVYTIRNVDNVPVYSLAFSFLPGGLERLLAGSKNGYVYAYNLQTNRVQQKIQVGQAPILHLIHTDNHLITQEKGGKFKIFSLTNSGYEEDALIDIDYPGFCRFDANTKLEALYVPDKDSKIHIYNFSGEKVGCLEPDSSLKLGEPMCLKFIEFPCDRPCLLAGYEAGWLLLWDLNTSQCISKLKTSECPMSVDFHLEQQRGMIGNASNVIQIFSIGRKDLSLAHKLDITIKNPGTNKVQTRSDGKVFASGGWDGHIRIFSWFSLRPLVVLTEHKQAVQDVVYSTEKVSFWNAKIMAAGGLDGAITLWDLYNTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L800</accession>
    <name>A0A835L800_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L800"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF5">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="181"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="35575" checksum="9BC44CDE53A51AAE" modified="2021-09-29" version="1">MEQEFSFISAISLGEVIVMGYIASGVKPALWLSLLHGFLFLIADSGTESPQEHSTMDVSSRHFRAEFLQEWQGSPDAPYFDPSTPRNITGLVGHPVRLLCRVKNLQNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAQHKPRSEEWALRIRSPQRRDSGQYECQISTTPPIGHAVFLNIVEPETIISSGPELFIQAGSTINLTCTVRHTPEPPSSITWTHGEQVINFDSARGGISLVTEKGLKSTSRLLVQRATGSDAGVYTCGPNNAPSAATRVHVLSGEHPAAMQQGCAKSTLDKTASILCCLLTIYVLRKPSFNDLQFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8K6</accession>
    <name>A0A835L8K6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">28S ribosomal protein S24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8K6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19791" checksum="678D098482A15E59" modified="2021-09-29" version="1">MNTSIIKLLQSGFGTSSVIAQCSPILASQLHTSAPLCRVVSGKYRITKKRDRPLTYEMANPPHYIAHRKSWNSWNTSNLKDGLRRSETAVEDEFIRRFMNGTWHSLVCSEVIIKRQFNHIRVAAIIRHAVSPTKMYFLLGYSEELLSNWLQCPVTLELQTVDSFKDVVFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8N1</accession>
    <name>A0A835L8N1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_009466</name>
        <name evidence="14" type="ORF">HW555_001731</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000510">
        <property type="protein sequence ID" value="KAH9636270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8N1"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000018">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000021">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 11" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="327"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9422737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9636270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="393" mass="44148" checksum="798B263AFAE6B307" modified="2021-09-29" version="1">MPYWYYDKKDLQNTPSFRDAITTETENRYRKEGARFIIDTGSKMDLGYNTVATGVVYFHRFYMFHSFRTFPRYITACCCLFLAGKVEETPKKCKDIIKVAKSLLTEQKFASFGEDPKEEVMTLERILLQTIKFDLQVEHPYGYLLKYAKCLKGDKAKLQKMVQMAWTFVNDSLCTTLCLQWEPEVIAVALMFLAGKLSKFEVLDWNGRNPKHNAWWDMFVEDITMELLEDICHQVLDLYSPQPQSSGGDSPPAPSPAKQPKNEKKPPSITPPTSASPVAVVVSKPILTPMKNGADIKVDPPKMEPIRYTYPAYPGMPAGYPAVYTAPPPSIPPPPRLPLTGPPPPSLVYAEPPPAPPPRFPPVNVPPPNYFPPLPGRGPPPPGPPPRPYYPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9K6</accession>
    <name>A0A835L9K6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit RPB11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_013367</name>
        <name evidence="11" type="ORF">HW555_002318</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000432">
        <property type="protein sequence ID" value="KAH9637881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9K6"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="10">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9637881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="13515" checksum="8142E04D8CBE5995" modified="2021-09-29" version="1">MNAPPTFESFLLYDGEKKVQKEEDTKVTNAAIFTVNKEDHTLGNMIRHQLLKDPKVLFAGYKVPHPLEHKFVLRIQTTSDYTPQEAFMNAITDLTSELSLFEERFKEAIKEKKEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9L8</accession>
    <name>A0A835L9L8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synaptic plasticity regulator PANTS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Plasticity-associated neural transcript short</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_017887</name>
        <name evidence="6" type="ORF">HW555_002348</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synaptic cleft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0545 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000561">
        <property type="protein sequence ID" value="KAH9635321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9L8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9635321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="19208" checksum="BF9D9ED44BAC728C" modified="2021-09-29" version="1">MPETATDGKKDTEATATVASEEDNEPEDKWVIRECELYKDEYKDCTSFRGRFQQYFVYGETLDCNQWKKDYDNCCKWQDYKDIKAANALIASEKERRMERLRAHYRNDVWKKRDSPPDDWAKPLPEWMQKRDENTYLAIKAKEMREGIEETTEKKFCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9Q3</accession>
    <name>A0A835L9Q3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000529</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9Q3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="69"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="224"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9424390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="50626" checksum="22EC568E9DE4156B" modified="2021-09-29" version="1">MKEKKEKGMYSYHKKDIMFVSNFKKNYLKIILCCVFGVVALVVMILPHVLMTSHVVHHRRHTRYPTDLKYILFWSHNKHKNFKPAMSRLKEFQHGQRTFIDQKCRYINCYITYSKDTLMNDEDFDAVVFDLNTVAKMDVSLLNLTRSPEQLYIFRSLETSAKYPLCDHDLEHFFNWTWTYKLTSDIPHPFLNIYSMNNTIVGPTTNMQWSTVMKKTRKYASKVKQKKKAVAWILTKCKLKSKHQDFIREIRYELSGYNYTLDIFGPCSANKCPGSSALKCYKMVERDYFFQVVVEEYLTEDYVTEVMVSAMSHLAIPIVLGPNDYSNFLPPGSYINAQTFNMKKLGALIDYLIKNPDMYEYFFDWKKYYFYKVHPRSNVCNLCKKLNEFNGTSVVKRHFRHWWDPEYRDECQRMRLFKLFNTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA16</accession>
    <name>A0A835LA16_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ATPase-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA16"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF19">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT RPN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="41844" checksum="DAF72C966138DDEA" modified="2021-09-29" version="1">MSNPLPVITIQCDWNDVIRLPKGTAWITSKKLNENGIHDKLTTCMSDGKVKIEFSDNYQYISHGPLSLVLKHIPSDLKVAFIAPSKAHKIHSKGVLSVAVAENALAVSSCEQDKLVVWDSRTGEVNLELKGHGGPVYKCRFFPSGIVVLSAGADGSCRIWSAESGINPVTLKGHTMAVCDICIIEKGRNVISVSKDGSAKLWDVGESKCLANVVEGHGQINCCALSTTSEEVEVGTKNKLLVVGCESGQVICSHVAKRAQIYSKQLDSACNTIIILDQSVIVGCSDGKIVKLNLEDGSLLKEWHESASPVLSMVVLTNQMFAVGRQDGTCTVLTLDEAHSKLRVQLTGADCDGIRDLSFNGKWVFAGCRDSMVRKYDFNQINVHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAA0</accession>
    <name>A0A835LAA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_001618</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032732594" description="Ionotropic receptor" evidence="15">
        <location>
            <begin position="19"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="17">
        <location>
            <begin position="222"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="16">
        <location>
            <begin position="346"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9422834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="80339" checksum="B7EA26B59EB77B22" modified="2021-09-29" version="1">MLLIKLSRIILSIHCVSAHGFFDIRDVTSDVMTTLPKDFSIAVKDIAEALPSKSITIVRGNSTNIRSQDVFELLCMLSEHNVLTTNLDIATKENKQKYYELLKKALDVSDQRTSLILCEPYECENILFELTDNNLIHSMILYIFYWSYGPVSETFLMTIKEAMRVAVLTNPRESVFRIYYNQGTSNRLNHLTLVNWWSGRLYKSPVLPPPDKVYHDFKGRVFEVPVLHAPPWHFVKYNNDNTITVTGGRDDKLLALIAKKLNFKYKYYDPPDRSQGSSISGNGTFKGTLGLIWKRKADFFLGDVTMTWERLQAVEFSFMTLADSGAFLTHAPAKLSETLAIIRPFQWEVWPLVFATLLVTGPALWIVIAAQSLWQKRKCDQLSLFSTCCWFTTTLFLRQSSSKEPSSTHKARLVSVLISLGATYVIGDMYSANLTSLIAKPSRERPIGTLAALEEAMRDYGYELVVESHSSSLAILENGTGVYGRLANLMRRQRVQRVRNVEVGVRLVLSHKRVAVLGGRETLYYDTERFGSHNFHLSEKLYTRYSAIALQIGCPYLETVNNVVMTLFEAGIIAKMTTDEYKNLPEHARRSDPVTESDKQGGEVMGESATASSQTPQGESTKGLQPVSLRMLRGAFCLLGIGHLLAAISLAVEIQLHRRSKRRRKPAHNEHRKAQKLLMLGKSVMLFKRGCKKVCTSVFTSIDKALGSDVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAF1</accession>
    <name>A0A835LAF1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="220"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1461"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1535"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1535"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1699" mass="193597" checksum="8EB00F5DD9FBCCB1" modified="2021-09-29" version="1">MSDSVEDLARRYRQNVLLQEHPRSIGLFTIPEYPELEANRGMWSVALDAILTTLRYLAPATLLTLFWGQQSFLFRILKHIDSAFRAIVFSSEEQKQSVLRWLAEAGPVRVEHLDTVWRHGWVLCGVLDAALPGACAGHPPTRLSLKHAQAIADHYLGVEPVFSRQELESNDSLSRHQEWKLATYLDRIREALSKLTPPVSKPVSQRTSPETTQFTLDYVAKGSGLSAAQVNNKASFKVYPTAQQALDPGEITILIRGPRDTYGMTVLPPILGKAQMIRQKLLGLQSKQNFTENVLPITQGATYLRSYGKNDMNKTYYIPKTKYDIEIDVETRTDHAKISYVVNLEGKYLISITSRGQSIVGSPFTITASHNIINTLEKDNYCLEDGEEIDIVDVKTDRKVVLRIVDFVTEKMLLKENGTLEKISDDEARILMTTDTENDMPNYSTESCSDVETSSESTVVKTLSFNKVASKILAMNRVCKVLNDLKSEKQLEFTKKESYLRSRSKQEIPDIVNSTLTETKAKPFIIPELREKYIVPESISVSLRAEKSTTSYETDLHNIRTDSEELIVNIPTESTRIDTPDSLDGYTETHEDQIDNLSDRMTQSTTNNPFLNDMFEENYVASKNLGPFVASEYERNNSQNEETRDSSITILIDPNVTPSPANNNPFIDIEDVGYIKPESILLERPKTPVLKIISGEKVDREESVYIDPKAELMAEETLGNEFVNPFFMHHHQSGHFEQPKPMTDFIIGAPVSLPPIIRARSPEPEIKPLILPGTDKRKGVKNKKIQDNKTEETRTEPVIPQTDLHLPKDVKNENISEDNSTFHSLESNLTIDNSNASTTSDNQYEPYQIDLSRNPSPRKDIWDSAYVSIDDNNSSPDSNNNENNIQCESLSKPKFSPSDDKFGLNQEDLSNMGPAEREIWQTCNELKIEPTKVQEEPKPYKWEIKRPTFTPIIEESDRSISSGTKDIPRNERCTKQGDSDSVSVAFAELNDMYQEYFPNSETSSTATVDENNKIHSTEVEYVTQTMDASVDSASDCNRLSQPLRIENDKIFEQKKENKDETQFGEVTYSNIVLEKKKYWDEKIRQIEAKSAETSIQPKRKRDYSQVKNINQTEDKHIEMKLQEPNEQKSQDEVNTNEKLVERWKKYWDEKLETDQVQVEASALITKSPSNKVRTLSSSSTSIKNENPVEVKVEATKYHNNVLLSEEHTPVKQELPEEVFKAFETSPKRFFGTSRKQILNKIDTFLGKPSADDIPTTDVTGGECHESGLVSSRISLFHNLSNTEPLPWARRKSQSLQNVSQRLGSNQNIVSSEENLHVELIERPNTETLEDRINEATNYSIKESANLKNKRARMVHSSFNKTLDETIYIEPVQEQFVTSTPNQKETARKTIQNVHKEYEPIQTTNKVLRKKSFSKSEMDIFNKIPNDTTDDGLDKYKSCDELPKINVKSFISLYESVTKTATAPKPARRVYRTSSADSQKNSPSHSINSERETEPAHLEYKNRFKMAKQFFQSIEELREVKKPRKLNECEQLLRKQSTESVENDRPQKRVKKNIKSHSMPSSEISKIWNELQETRDSSSNTKLVKISEKFNVEDLFTDVTEGKLSRQGSLRGIPHKKAVLEAFRSMENITLHHAALRLEVPRGVARRIVTQRCIAGMHGVQEQCFVTRCRATQREAAVATSLLFPSRLRLELMQFGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAN2</accession>
    <name>A0A835LAN2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_002422</name>
        <name evidence="9" type="ORF">HW555_001905</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000528">
        <property type="protein sequence ID" value="KAH9635862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAN2"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9635862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="164" mass="17595" checksum="8676BDDB80D0F9A5" modified="2021-09-29" version="1">MPPKFDPNEIKIVNLRCVGGEVGATSSLAPKIGPLGLSPKKVGDDIAKATSDWKGLKITVQLIVQNRQAQISVVPSAAALIIRALKEPPRDRKKQKNIKHNGNITLEDVISIAKTMRARSMARYLSGTVKEILGTAQSVGCTVEGRPPHDLINDINSGALTIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAR9</accession>
    <name>A0A835LAR9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001848</name>
        <name evidence="8" type="ORF">HW555_006436</name>
        <name evidence="7" type="ORF">HW555_013744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000715">
        <property type="protein sequence ID" value="KAF9405590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000096">
        <property type="protein sequence ID" value="KAF9416113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAR9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="21183" checksum="0DB0F496D76E475E" modified="2021-09-29" version="1">MPRRECCVFGCHQFDVLHRFPKPETSLERFLEWKKIVGSKLEDKTNDDIYTNCRICNNHFEERFFYPQSKRLAKTSFPTLNLGFISSNQDESIEIQSVPEVLSESMDIDMVPQILPGCSSQVPNPELVTKTGKISKVKQTKQMEIMIKKIDYLKKKLNVQKDQIKAAQKMETSSTSRMYRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAV8</accession>
    <name>A0A835LAV8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAV8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="298"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="2">
        <location>
            <begin position="397"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50794" checksum="953DA6096E2BFCCF" modified="2021-09-29" version="1">MRSSKYPDGKTKKNLDNKYVRMIAVDMEPLRKGEHEGFRDFVNALDTGAARAVALADAGFSQRRIGRMLGYPRTTIQDAIRRYRETGSYTRRPGQGREAEVAGRGCGALIGFPVEKYFPNQYHVSCAPGVQSKTMDPQPSTSQSAAIRDEIHDTLATWESAYFANEEVVHINQGLLYDDDELYGILADNVEDTLENCSQGIETQEAHDLSFCEDFSSDNETEDVTTTREWHYGNAPNTNNLDFTATAGLKAIDMGTLKTFIGLVIHMGTIQYSRMSDYWKTHYLFKNDIFRKYMPRNNIPLTRELLNSRTFCTGTLKMNRKGNPKELLKTKIKKGECIILHDKNNITLAKWMDKREVLFLSSEHNKRLLPPIHPREEIPLAICPMHFPKQITKEPNSRRAKRKQCRQCAKQKKRVDTIFYCPNCPDQPGLCLNCFKPYHRYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBJ5</accession>
    <name>A0A835LBJ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000003</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBJ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="781" mass="87282" checksum="0508637269D37812" modified="2021-09-29" version="1">MPRKRVIPKTVTWLSEEIHEPQSLTPTFHHYTKFQFENIIGEIGDYVLISNADAAEPDTEAGCDAARILSLYEDRSNSTDPFRAKVQWYSRPADLPNWCFSHMEPISFHEKEVIEDHRPFNQDVSIETFFKKCSITLTFTKDMDETITEPYHYICRYRLMAMSRRKVQIEPVLEHERKALALLSTPNKTPSKTVTPKTPTSLVKRMSRVSISEKNWSVTKNDGTKLLLKRAILADKNEKDSPKKNTPKATPKKSTATPKSSKKLTNSNIEDVLSMELKENSDDEIPTLIIRQHVPTTPKRKQSISTLTNEETPKKVLVFEDEDMRTPTRSSRIKTNVNYQEPEESPKKRTPRKLIRKTSESDDDFRPAPRTPKTPKTPRTPRNRTPAQTPKRSVTKRILTSQLTPTLHNRAHSIDNIDEFLKQNKSLPGREGQMEEILSFVKTKLLDGTSGCMYISGVPGTGKTATVSSALKYLKEEVDHLPDFQLVEVNGMRIAEPRQAYVQIYKQLTGKSVVWEQACSLLEKRFTNPGPRRTPTVLLVDELDALCTRRQDVLYSIMEWAAHNTALLTVLAVANTMDLPERALAARVASRLGLTRLTFPPYTHTQLQNIVATRLSGANVTADAVQLIARKVAAVSGDARRALALCSRALELAGPDGAGLKEVQQALGEAASSAAVRAIRNCSPAERLMLRAVAAEVERTGSDETTLSRALQTAAAIVALDGRPYKSAPSIRAPTPSQAQAICARLAALRLLLLEPKPAEPRLLLNISADDVHYATKQIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBY4</accession>
    <name>A0A835LBY4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial genome maintenance exonuclease 1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGME1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBY4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK endonuclease-like" evidence="3">
        <location>
            <begin position="245"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="46420" checksum="6BAD94A19D72F98E" modified="2021-09-29" version="1">MFRPVCTIGQRISFERKSREFIRNKVVRPASFLNPAEKLKLFNKENKELFGPLLESSKQKKQRARKAAKNRTSHQNNDSTASNENKLKFLESTERNGGQSQILTGYVKYNPVLAVNVLKTKMWQNTRHCVNFVGVVLNNTVRGVATSASCNAARSSPAQPGYASEDKILQIKPHKNDYAQQYPSVTLILNKTMTDESRSALEKWKQERIAEMGLEEFNKFYAAQMAVGTKFHSTLKNYFTQPQTQLRIEKEVEGVWVSVADVLKHISSPKAIESNVIHPVLKYRGIFDAIADYDEKPTLIEWKKSDKPRKSIANTYDNPVQLAAYYGAVCHDLNYKHLNVRDALLVIAYTDGSKADVFHLSSDKLREHWAQWLIRLEEYTKKFGNDSEKLLKGGKRLFEEDIGNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCV2</accession>
    <name>A0A835LCV2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000040">
        <property type="protein sequence ID" value="KAF9419705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCV2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin I-set" evidence="1">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="12808" checksum="504A978925E0E5C3" modified="2021-09-29" version="1" fragment="single">FIAESREGTLRLNITAATDADEGDYTCEAVNNIGFIYCTGHLKIGNPPRIVRMPGDLHLPEHDNTKIKILYTGDQPADVVLTKDGHKLSDSPHFKYTVFDDYILIFIKDITKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LE23</accession>
    <name>A0A835LE23_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_009144</name>
        <name evidence="3" type="ORF">HW555_002575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000077">
        <property type="protein sequence ID" value="KAH9644569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LE23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9644569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16862" checksum="E725ABCDAC3A4964" modified="2021-09-29" version="1">MSGQSRNVYWIVVRNFINSLKPRRSKGNDMGKDYIGNSYFEIPAAPSEGKRKPTRWYNPPKGQDFQDPIPAEWEAWLRMRRQDPPTEEEISKNLAIAQMKKINAAKIEAKRLAEGGSLPTVPEKGHQSFPVYPDYHPGEQQNKPPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFP1</accession>
    <name>A0A835LFP1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_007614</name>
        <name evidence="12" type="ORF">HW555_001093</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000189">
        <property type="protein sequence ID" value="KAH9642482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFP1"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.20:FF:000002">
        <property type="entry name" value="ATP synthase subunit O, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9642482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="209" mass="22652" checksum="A885C8BE1C4A913A" modified="2021-09-29" version="1">MSVTKGNMLVRSLSTSAAASQLVKAPVQVFGLEGRYASALYSAATKNKTLDAVEKELSQFQQSIKTDAKLKEFIVNPTLKRNLKADALRQVATQAKLSPTTSNLLGLMAENGRLDKLEAVINAFKIMMSAHRGEVTCEVVTAKPLDQTQRQNLEAALKKFLKANETLQLTAKVDPSLMGGMVVSIGDKYVDMSVASKVKKYTELISTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG45</accession>
    <name>A0A835LG45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Connectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_017391</name>
        <name evidence="5" type="ORF">HW555_000614</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000920">
        <property type="protein sequence ID" value="KAH9628316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG45"/>
    <dbReference type="OrthoDB" id="2020019at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032293894" description="Connectin" evidence="4">
        <location>
            <begin position="23"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9628316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57226" checksum="1A0C766FE94AEC32" modified="2021-09-29" version="1">MDLKYLILMIAFATVEINVTESRQNDKRRWKNDKIYSHYVNICDIQDRGSKVHCYCESIKIKTATKADCWVFNGGIAEDDPFWSNFYSQPKIEKLTFNVRADGGLTYIPAKVIVRLERLQYLNIQYANIYSIPSFAFTNSTTLREITLPKNKIAKLEKMSFAHLIMLSNVSLVENQISELKRDVFYVLPNLQRLYLSKNIISVLHDGCFKHLNNLIKLDLDNNQLTVVIRENFQGLSNLITLDMRNNKLTMIGDLAFAELWSLQELYLDGNEIEFISERGFGGLTQLRKLSLADNKLGTLDDGVLDDIQKLNVLDLRNNNLETLKQEAVQNVLENMKSNYALISLDGNKLTCDCRLSWLHKLRNETKSKRVKASLSRLNCIMDSKTNVGTLKIEKPQKAIQGSYKKEMDYEEEEFEEKHYDDAMQDQETDNDDTKIEYKRKLLEIPTEMLPCPNRLIYEASFSPPTQDEVKYYKTSSSHMLVATTVNLLLSVLAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGL5</accession>
    <name>A0A835LGL5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="580" mass="65980" checksum="B822F1067419E7BC" modified="2021-09-29" version="1">MVNLPKPVQQVLTKLVPASVLKNIICFVFYDKHPNDDKNIDVTLCTTLGEVLEYYKRNLVCSIKLPNNVKPTAIKNIRNPNCDLFYLVSAKEQITILARKDKLSVHQIVNNVDKYDIADGSCSGQAILRIFRKGDAIPHIFDENFETFKRPDISVTVSEPGNDESVPIIAHLMRKLTEARYSVQHSEKTYKELLELHQRVAFECYKKIHPNLQDSVFNNGPEEIASVLRIKTKSPWIKVCNKKIVIVIEVSNLNKENLEDVHILVHGTTGESIEYTTKLFEETFIITNNLPFWTEIQTQTLKPKISSAIVLVMDIKEVIDSLTCKLCLNGVIFYKRKGKEYLLPLQEIELYAKDTIGAKFDAISDTPIDSKTMLAILATTEKTELLLRHIMRSSEVALSLEILCQYLMMEKLDNYSNIIIHRSSPYHTLNGVMIVMHGEQTDVNNYTTLCVYSRTPSQVLALIHCIHDAVPLTLVITTPDQKLTAKDDKLAKFNEESIECTQKLYNYQNYASTILKRTKLALKYLDDSMVKMGEFKNPLVQSKIGSEIDLFAAVPLMDSMFSYSEDCDWTEALIGLQEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835FZS2</accession>
    <name>A0A835FZS2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001013">
        <property type="protein sequence ID" value="KAF9404335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835FZS2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="195" mass="21710" checksum="04C678144537E14F" modified="2021-09-29" version="1">MDTTSVTNQKKSRSVVVNLKGQASSARSTNFPVGAGKSSILSRMKVRKQSFGFGGITGIRSTERRTSQLGSEYKRPPLVYLNTYQLEPKTTFRVPDVEAAINGVLDAYWEGHVYNATESPGLTMVIAGEVMRNVKSLCFDRYRIIAVVSLVQKRSQSYNNAVAFLWDHERDGIADILRETTTAFIQVTVFGVYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0Y8</accession>
    <name>A0A835G0Y8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_013812</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000736">
        <property type="protein sequence ID" value="KAF9405461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0Y8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="45"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="688"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="912"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9405461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="968" mass="111328" checksum="60FA5DDC7806BA81" modified="2021-09-29" version="1">MLHLQNWKVTYQQFQQRFIKSTTNVVLKPNVSANAYQPRNVEKQKYENWEKYNLFTAENSSTKPRFSMVLPPPNVTGSLHLGYNVIWLPGIDHAGIATQGVVEKYLKTKQDITRHDIGREKFLQEVWKWKEKHGHVIVNQLKTLGCSLDWSRQTFTMDQKHTHAVNTAFMTLFKKGLIYRKKALVNWCSALNSTVSDIEVENVSINGPKDIQVPGYDRPVKFGVIYYFAYQLYDSDEYIVVATTMPETMLGDTAIAVHPQDERYKHLAGRRVWHPFRNETIPIIQDEFVDKEFGTGAVKITPAHSKVDYEVAKKHNIPLIQVIDENGRMTTSDRFNGLKRYECRQLILETLQNVGLLKDAKPHQMTLPTCSRSGGVIDHLPKEQWFLSCSRLNERAATLVDKGSLVIEPSKYIKYWKDWTGDDRDWCISRQLWWGHQIPAYKCSADRNIVWIAAHNEEAAKMEASKVLRTLPDIIKVERDPDVLDTWFSSGIYPFAALGWPNSFNNKDLETFYPLDLLATGHDILGFWVHRMVILGLELTEQLPFKKVLLHGVICDNKGAKMSKSKGNVIDPLDVIEGINMENLRDKTKEMHKNGILSLSEMEKALSYHQTNYKNTKGIPECGVDALRFTLLSHDIKSHFVNFDIAMCHSNKLFGNKIWQSVRYTQLSYSKLPVLSTELSEASLTYFDKWILSRMSDMVEIVNRSMDNYDFHLATKAIRAFMYNEFCDVYLEATKPGFAGKDISKAYAHAHTLSAVLNTSLRCLAPFMVYLTEELIPKVPSFSNNIVFNFTDASNKYLDFPCKDDFVQWKNDSIEKDVSRFLNTIFLVREIKGLYNISNKVRPSVFIDKFDDKLRGDIEGNRDVFLNLSRCSEVMFRPDPDKKYVTGVLDKNLEVNVELLGEDVELAIFAAKTKLEKKIQQLTDSLSKLEAKFASEHYLATAPQTAQAADREKLESKKKELEQLQRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1I8</accession>
    <name>A0A835G1I8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000647">
        <property type="protein sequence ID" value="KAF9406052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1I8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="350" mass="39585" checksum="1B0442DAFABA2A5D" modified="2021-09-29" version="1">MNLESKKKWRCKMCVRNKKFTSIGETSNVTTRKKQSSLKTPSPTEILQHVKNNPRTGTSKDQPTIQNTSENDSHVLTDCETSDESFITPNKLSRSFDGTISDLVKVSEMKDIISQLTLKLQSAECELENVMLENTDLHKQIAKLITEVTTLKSLCQSPSMFGTPINMMKKKKEEHREKLNSTLSTPASLKSKLEPADNVILNLKPKISTLQQQLQLAEQEVTTLKTRIKSLIQQNHNSTSSLSSSRVHTTQELKRCPATSTSPLPTHRRVMEPEKRIFVFGTQRCVGLAAAISHSRTNTSYEKYRVIAETKPNALCSEITASCRSIKPMPDDKLLICLEMYLWLKKDLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2K8</accession>
    <name>A0A835G2K8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000754">
        <property type="protein sequence ID" value="KAF9405358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2K8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="644"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="737" mass="83974" checksum="9ACDDF018EC69D6D" modified="2021-09-29" version="1" fragment="single">ADRVKKVLCGWIVISGRYNYCDEMIIENPDAFKSWLTSILEPLCDADPAALAKYVYALVKKDKPLDELREVMVDQLDVFLQQETKPFVEMLFKALESNDYLKQGKDDKKAPSPAPGDSEPSKEPETENHVGAPTIPSPVSGGETRGRSPCAGTVAGSTGAAGARGRLVVSRGAKLAAPAPNAPSAPTPAPPPRGHPHNEHTLVKVLPLTELLEEPVDQPPRRRDRRGDSTREADRRRRRSRSWERRARARRHGRDNEHNTDIRRRPLSRSPSPRGRYRNRSPPPSAIDRQISRSRSRSPAGRERDHERERDRLRVPRELERDRMSRDREHRDRVSRSRDRDRSRDRSRDRSRGSASPHPDSRLDHNDAYKRRCRDFDEKGYCMRGDLCQWDHGKYNPLTPDIWCGGFPAYPPPHPHHPHPPRELIPIPRIRHEMVSARGVGAVGAAPRPPAPHKKNFDYTLKKVPRGLNDITHLNNHFCKFGKIVCYDGDPEAALITFSTPTEANVAYKSTEAVLNNRFIKVFWHNPEQNKQENMAPGGQMSNKQTDRQNSQHPMSHNKVLINRDNIKATADNNAKQLMEKQEKEKELANGQDPKKEVVKPPITKSKQVMEMHKRAQALLETQLQQQMLLIQRLESGNVTGPQRAALLEAINSAQEGIEKLRKELVAYNGTLKQMQAKKPKTKEEAQKEILDAELDLFTKQQEGQDVTELTKKIAELRRQMAIQFPSHNIMRRPHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2Z4</accession>
    <name>A0A835G2Z4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_014493</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 14">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 14"/>
    <dbReference type="EMBL" id="JACKWZ010001071">
        <property type="protein sequence ID" value="KAF9404144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2Z4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000003">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="15">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="12">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9404144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="132" mass="15017" checksum="DAAB4EC6819B8D9E" modified="2021-09-29" version="1">MEQTLVIIKPDGVKRKLVGEILQRFERKQLNIHQLKVATMSRELAEEHYAHIKTFDFFEDMMTYMTSSEVVYIILEGNDVIKTVRKMLGATNCLEAESGTIRGDFGGSSYQNVVHASDSPEAAAIEIKRFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G333</accession>
    <name>A0A835G333_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000805">
        <property type="protein sequence ID" value="KAF9405132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G333"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038757">
        <property type="entry name" value="BRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259:SF1">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="334" mass="39460" checksum="272F10A3617FB0DD" modified="2021-09-29" version="1">MSNHEVIQEYSNSIKHLKKECIDAGMTEEEFRRMYLSSLETLDDEERPNNVPRRVITKFRVSLVMLFITLYIVYDYKSIYSSIVCNLQEFIYPGLKLLRKITIPFISLFPSLTEYYHETCLIQNPYFSVVDMDCWPCSTVTNIREVNDPKPVTQQQTAPFIYETTQQIINLEALKQMYLKNRESFDKESPKILTNNKYYSSPNYLFIDRPLEDQSFYIWKFNNMNVAKVLRQVIPRPEVVPKFGQSTERFIIVDTSQRSFSIPDTECSFSFLLALSGSREIHLLPAEECKHQCKTLKVKLKETYLLWYNWWYWRPAVQSSMGNNTFIAHVGSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G361</accession>
    <name>A0A835G361_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001019">
        <property type="protein sequence ID" value="KAF9404308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G361"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000056">
        <property type="entry name" value="SelA-like pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020043">
        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006337">
        <property type="entry name" value="DgaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047601">
        <property type="entry name" value="EF_0837-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03583">
        <property type="entry name" value="EF_0837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01437">
        <property type="entry name" value="selA_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="DIHYDROOROTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE AND RELATED AMIDOHYDROLASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="564" mass="61210" checksum="D0A2C812F8795A32" modified="2021-09-29" version="1" fragment="single">MNEIGVKKGVTTVIDAGTTGAENIHEFYDLAKQAKTNVYALVNISKWGIVEQDELADLSKVKEELVHKALAELPDFVVGIKARMSKTVIGDNGITPLEMAKNIQAKNNNLPLMVHIGSAPPKLDEILAHMSKGDILTHCFNGKPNGILDQTADKIKEFVWSAYDKGIVFDIGHGTDSFNFHVAETALKEGMKATSISTDIYIRNRENGPVYDLATTMEKLRVVGYDWSDIIEKVTVTPAENFHFATKGRLAEGYDADITLFKIEAGRMTILGVSKVSEKVLAAQTFGGEHFFEMSELGIQTGAYLAELLNVEDAQVVSSASAGIAQSVAALIGKGSSYHVYHPYTEKITKREIILPKGHNVDYGTPVEVMVEQGGGQVVEAGYANMCSPEHIDMMITEQTAAILYIKSHHTVQKSMLSVAEASAVAKAHEVPLIVDAAAEEDLFKYIEAGADLVIYSGAKAIEGPSAGLVIGKKEYIEWVRLQGKGIGRAMKIGKDNILGFTQAVEEYLKIGSETGDSMQARLASFIENLNRIPNIEAKIVQDGAGRDIYRASINVSGEKSAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G391</accession>
    <name>A0A835G391_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000867">
        <property type="protein sequence ID" value="KAF9404848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G391"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051319">
        <property type="entry name" value="Oligoribo/pAp-PDE_c-di-AMP_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47618">
        <property type="entry name" value="BIFUNCTIONAL OLIGORIBONUCLEASE AND PAP PHOSPHATASE NRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47618:SF1">
        <property type="entry name" value="BIFUNCTIONAL OLIGORIBONUCLEASE AND PAP PHOSPHATASE NRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="229"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="315" mass="34620" checksum="3B5543103FD46D6D" modified="2021-09-29" version="1">MNVVDQILTEIKAYQTIIIHRHQRPDPDALGSQVGLAEILRTSFPDKAIYQVGGSVEGLEFLALMDEVADDVYQNALVIVTDTANSPRISDDRYTLGAKLIKIDHHPNDEPYGDLVWVNTEASSCSEIIYDFYVHHQDDLVINDAAARLLYAGIVGDTGRFLYPATTSHTLKVAAELMSYDFSPTDLNRELEQIPMSVAKLAGYVYQNIEVDQNGAAKVIIPQALLSDFGIVDSETAAIVSLPGVIDEVLAWGIFVQQPEGYYRVRLRSKGPVINELAKKHHGGGHPLASGANAKNLAEVAEIYEEIQQVCKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4F2</accession>
    <name>A0A835G4F2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000675">
        <property type="protein sequence ID" value="KAF9405827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4F2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="213"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="634" mass="72382" checksum="19DF06EFE9B7BDF0" modified="2021-09-29" version="1">MLTRNMNLNRTCLKYFSVSSCCRQTKTLLRQQKSIASFNNSSLHDKNITYNPSFCPTKGLHGIKESVQTLVDNQNCNTFTYRTHNCGELRPEHEGQKVTLCGWIQFSRLSKFLLLRDAYGLTQCIVNDDNISFSEIPLETVVKIEGTVALRPKDMINKTMPTGAIEVVMTKLEVLNTVDKLPFNLRDYQKPKEQLRLQHRYIDLRFPEMQNNLRVRSHMLHNMRRFLIENHGFVEVETPTLFCRTPGGAREFVVPTHHEGLFYSLVQSPQQFKQMLMSGGVDRYFQVARCYRDETTRPDRQPEFTQLDIELSFTDLDGVLTMIEHLLYATFVKPLPKPPFRRMTYKDALKNYGSDKPNLTFDLKFVNIKNLFPEKSNEEDFGAYALPYSKQIGKLTTKYKEKIREFAKKYSCKVVLNENVTKELGMEIGARIQSVIGDEAAIIVLGEDENACQCLGEIRLIMASILKSKDLLQVKENVEPLWVVDFPLFVKGENGLETCHHPFTSPHPDDIHLLDTEPLKVRSLAYDIVMNGNEIGGGSVRVHNAELQEKLLKILDIDSFKLSHFLNALKCGCPPHAGIALGIDRLVTLACDAESIREVIAFPKSHDGRDPLSGAPNTISEDDKKYYHISTVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4F5</accession>
    <name>A0A835G4F5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_002122</name>
        <name evidence="1" type="ORF">HW555_012831</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000521">
        <property type="protein sequence ID" value="KAF9406993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000343">
        <property type="protein sequence ID" value="KAH9639433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4F5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9639433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7796" checksum="8EAF5BB2F3ACB5B4" modified="2021-09-29" version="1">MQRNPAFPSAMSSGYKSFYPSPCFGPPRNQYSAGSYAQPTQPFQPSNCFMTASAIRKMSNTTPPSGFGRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4H8</accession>
    <name>A0A835G4H8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000667">
        <property type="protein sequence ID" value="KAF9405877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="3"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="848"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1315" mass="147435" checksum="0235A12BA7FD3BF9" modified="2021-09-29" version="1">MEQKSKKFPVLVFIHGDSFEWSSGNPYDGRMLASYGNIMVITVNFRLGILGFMKPSLTEHVYGNNGLLDQLAALQWIKDNIEDLNGDPTSVTLMGHGTGAACVSFLMLSPISNGLFHRAILMSGSALSDWAMTKDPTPYTLQVAQSLGCNPNSKNMMACLQKKPLSEIKKVQILAREFETPLGPVVAGSFIPNEPAKTMESFPNLLSKYQLLSGVTELERYHDFGVIELEHGVLENQRDDFIRKYAKIIFEGAEDETLKSILKEYSPSKLDPQRWNVETNRDVILNMFSDARTLAPVVRFANYQSQANRQSYFYVFGHNSISSDYAALNKSVQGEELPYVFGVPLGVTNTHFNPDYTQQEKLLSEVIMRMWTNFVKYGSPNSQAPVKFYNMDRRQWSLYDIDWPEYDGTRQSYLKFDIPPEVDTSYRSNYTKFWIDTLPNKVSKYIVDPLFEYTPPPPSPKPKISHRNTGNAPSETKPTSKYTSSSIKDPIRRIWAPQVAETPHYSSSGIYGKMRPYSQPVRRPDSNVIYKEIMSIEKPARPVPSGLMEKTVTHFTHTTTSKPIVNLSVKTSSATIALIVSLAILFLAINVAICFIFYIKKRKLRLREQTLESTHQPRAEIGEVDVIGQKSSKDDKSALQTLKNGCSVIKSMSFNKMKNNSKKHKKKSEVCKTPKSDDSGGFRERFKLRRHLSTSTLDAHTKVRDWIANEMMHRCSPGILRKSNSDLNEKHMTVAKPFTRSEELLSDTKKSKKDNLKINESVNSKSLASKTYSKTRTSEKTTSTSALGSHSSIGSHKQSLSSIKQTSKSNESIKSKATESIKSKKVSVAIDATPAARTNSILNQEPIEISKSFDNGDQIHSNKTEKSTEVELKSPDANAGAKDDEKTFTNVVTLSVQEKPLIISHKHSSSDPVTDVNYDKLIEKMESANLMNILPPVTFRNDINVTSREERPQINPMTAEEALLTIKKRNFPKVLPDLPKAQKRLSLQPTTLQTFRGYSSMDERPKVPPQPPPRTTTLERRLAYKNTKPLSSFDASNVKKINEDTTVIKNYENIDSLSPYCNAASRNASFERNVPETNIILPKDRELPRVIIASSDNPSSQAPEIVITPSPSQVEIPTNAPRVRLPDDFHMQGSITSFSSFCSDEDEDDDIDIDEEFEDKLIQELVGGVDSPTNMEDVLDSKGPDSIFEKKLEIVPVKINPGIVVPKSKDDYVCVSDLFLPDVSDLEKTAQIKPNFGLNKLQHRTESIHRPPEKAVKVKQRKSRTPSILNKSSKGKRGSDKSRGDSVKLEHSTSGSSNDTETSTGTVKKVELKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4K7</accession>
    <name>A0A835G4K7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_012731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000503">
        <property type="protein sequence ID" value="KAF9407129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4K7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9407129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="49875" checksum="8E4896DB91717EEF" modified="2021-09-29" version="1">MLVRMDRCSALSPSTPSSRGMDKYEQLSVVGEGSYGVVLKCRRRDTGQLVAIKKFLETEEDAAVRKMALREIRMLKKLRHDHLVNMIEVFRRKRRFYLVFEYLDHTLLDELEAAPGGLGEDTAKKHLYQLLKGIDYCHQNSIIHRDVKPENVLVSNAGIVKLCDLGFARALAAPGEPYTEYVATRWYRAPELLVAEHRYGPEVDIWAIGCLFAEMLTGDPLFPGDSDIDQLALIIKTVDNFAENFNAELRKKLGKEIEAAPTQQSTARVAGKPRQQWTLNIIPDQSRSRTDNTEVQMETGAMDKKPHRSVCEPAHETTHSESGAPAVRALPPAPRPAPPRTLARAINDTFQTFPVPVNTYPRTPYIKKVNNKLVMDEELLRGRAAAKKGNKKTPELSLPYMPGGKQHNRNGGNRASNSPVKKVKKPLPAYQTLSKAYDNWEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4R6</accession>
    <name>A0A835G4R6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4R6"/>
    <dbReference type="OrthoDB" id="10262032at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007914">
        <property type="entry name" value="UPF0193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28348">
        <property type="entry name" value="UPF0193 PROTEIN EVG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28348:SF1">
        <property type="entry name" value="UPF0193 PROTEIN EVG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05250">
        <property type="entry name" value="UPF0193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="36388" checksum="EA978D7A9FC64E28" modified="2021-09-29" version="1">MPTYKLGVFNLGMNSGNKKIVDFLFGGYPGNVYKHRSFLSEKSKMLNPDGNGYVHVTWPSKNVPHGGIFHTRVAEPTDSQQLLLKVLLEESKITIAQQKKSALRLRDDKERRDDSELVIQTPVVRPRTSRKRSLSTIRDSGAFDGNGYRPLKRGEDREKLKERLAYSMAFGNDQQQPPPVFPELKKQQPKLPTAKQKWNDLVTQIRERSEWLAEMEYLGQAGPHRDIIKDQIAERMRALDALGIDSECSTPKSSASGFSTKTSQSLDLKSHRSTSTVVTKMSMNGNKNQIALNRRSRNKEENVTAYSQLSPLQYSPRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4R7</accession>
    <name>A0A835G4R7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000681">
        <property type="protein sequence ID" value="KAF9405795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9405795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="577" mass="66752" checksum="7F3E1E96AD9D50B4" modified="2021-09-29" version="1">MSQEQKNIDCRICLRCDLNKKYRTLSLFEKYKHFIITDKIKYIANIEIKENDGLPSKICTDCLLQLETAIIFKQKCETSNKILQTIVHQPSKGCNVTIQLPFTKEVNVDNTIKRNNSSCPSVPEHKDEVQQLISKQDQQVVLKNRPKLNEVKVKRSDNKVKELDQIKKETETVFVKIEDSINFNVPLESENNESVNEIEQLDDGVVSEHGEPVNDLTVKAETLTEDDKTNEVDDAKKVKKEKKSKAIDLQIICDDCGGTFKTKCKLSVHWKKVHLPNKLICPKCKRTFKTFKAFNVHSKKMTRSCYAATLVRIEGLGKERIFHCKDCTYHTKNIKDIDAHLVTHNGIRRYQCKDCLKWFTQHSSLQGHRESHHNDYKIVGTCQYCGKHIKGRKKLYKHLLNHETKSVQCEVCKKMLKNPSILRNHMKRHSGVRSYTCESCPANFFTMGELCNHRSRVHFKAKTFKCNMCGYLTTTARLLGTHISRHTATNVVCLMCGMFIENEDKLAIHQKRHMEQNFVCRHCDKGFFLRDSLRRHLAKKHNDLSPNSLDQSKPVNVKQECPVENKLRNVNISPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5S4</accession>
    <name>A0A835G5S4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">18S rRNA aminocarboxypropyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000315">
        <property type="protein sequence ID" value="KAF9409490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5S4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="7">
        <location>
            <begin position="127"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31705" checksum="526AF00F5B99FD78" modified="2021-09-29" version="1" fragment="single">IKHNGIPIEHSLIAYLLKYANLWLVKEILFTINKMAPGKKKVHGKRSNHHVKREYAERLNDLRLESSGDSSSDGSSDGSNNGEGVAPTFPVSMWDLNHCDPKKCSGRKLARHNLIKNLKLGQQFRGLVLSPVGKQCVSPNDKEIIEKFGLAVIDCSWAKIDETPFDRMKSPNPRLLPFLVAANPINYGKPYQLSCVEALAAAMVITGHRKEAQFYLSKFSWGHSFLELNSEALELYAACNDSKSVLEAQNTYLENVKNEKDDREMWPPTESETETESEDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G645</accession>
    <name>A0A835G645_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_012680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000495">
        <property type="protein sequence ID" value="KAF9407210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G645"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04155">
        <property type="entry name" value="Arl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000281">
        <property type="entry name" value="ADP-ribosylation factor-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9407210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="238" mass="26547" checksum="57F76DD0A8B3118D" modified="2021-09-29" version="1">MVDLNRARDWAPLGGGATDARNGDGPYGWRPFDIREVMLLLTNCAVNAVGTPLTNQDYGLLNILKKLRSNPDKELRLLLLGLDNAGKTTLLKQLASEDVNHVTPTAGFNIKSVLSNGFKLNVWDIGGQRKIRPYWRNYFENTDILIYVVDCSDHQRLEETGQELAELLEDEKLRGVPLLVYANKQDLASALPASEIAQHLGLHLIRDRTWQIQACVATDGTGVKEGMEWVCKNIPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6B7</accession>
    <name>A0A835G6B7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000374">
        <property type="protein sequence ID" value="KAF9408579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032710065" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="275" mass="31295" checksum="1ECF8F6BEE547F10" modified="2021-09-29" version="1">MLSVAAFLLLFAQYDCFKTLPFHNSTKEVLYPLRSGVLGYKRTIPDYFDWRDHDGVSPVKDQMHCDACWAFSVVANIESHRRIYLNENDILSEQFLIDCDVMQDGCAYGSLIQSFANIATKFGGVLRDEDYPGYSDRKEECRWQTYKGFSYFQVSSSPKAIPVVGFRRVNPDESIMAYYIYTHGPLSAAINSQSMARYKGGIDEPTDKNCNPTILNHAVLIVGYNVYISETGKRTPYWIIKNSWGTEWGDYGFYYLVRGRNACGIASDVSFAYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6I4</accession>
    <name>A0A835G6I4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exosome complex component CSL4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000410">
        <property type="protein sequence ID" value="KAF9408070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6I4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000198">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24683" checksum="F6E4ADCE36AD4510" modified="2021-09-29" version="1">MSSEKLKETGKLCIPGMRLSLSNKEFVSGPGTYELRGYIYATLCGTLKMELDENEVTVVSVESPRTPSILPRTGDIVTAKVTVVNPRMVQCVILCVGSSVLVRPYRGILKKEDIKATEKDRVDPYKCYRPGDVILARVLPMTEIHWYHLSTAENELGVVIATAEGSPQGISMLPISWSEMQCPKTLVKESRKVARVIPENINEALFPVKDNSTTELEIKQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6W2</accession>
    <name>A0A835G6W2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TraB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_016912</name>
        <name evidence="2" type="ORF">HW555_012303</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000434">
        <property type="protein sequence ID" value="KAF9407806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000520">
        <property type="protein sequence ID" value="KAH9636038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6W2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9636038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44277" checksum="4925A6075E9EB1C2" modified="2021-09-29" version="1">MDAADRLLNNERLGAQNLEEDQLLRKPQPGVKSDLVNECKVFIKAEDGSGDAQVNTFAAMIPKQSVSDKPNATSTPDQKKETPSDDHVIVDSNPECDMEDGISELPTDDGLPSTVTVLDAPDGGKVYLVGTAHFSIQSQEDVSRVIQEVNPHIVMVELCEQRTNILLLDEEVILREAKNINIKKIRATMAQNGVFNGLMYILLLNMSAHITRELGMAPGGEFRRAMAEAKKVPGCIVQLGDRAIDVTLHRAIASLSWGQTIRFIWHLLTSNQTISLEEVEKCKQKKMLEDMLEEMAEEFPALKRVFVVERDMYLCHSLQVAALQPRREPCRIVGVVGIGHVAGIVEHWGKIKPQDIPPLLQVPPPSLSTRVIRVTVRVACIGALIYAGYKLRPRRWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9B7</accession>
    <name>A0A835G9B7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17633" checksum="0A911E01FED4255C" modified="2021-09-29" version="1">MDIRCFRNHPPQFTPFVPQKQDIDEERKQPTPPPDQWAEILGIPGEDDDKKPTKYTRKSQNSESKDKSKSATTSEEEQPSPKQLRSSKKEAAAPTPEKAEKSPIKPPPKKRKPEEFQETQDVETAAVAPKKEKKKVEKTEKNDKRKRKKSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9E7</accession>
    <name>A0A835G9E7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 subunit C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010478</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFC2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000263">
        <property type="protein sequence ID" value="KAF9410427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9E7"/>
    <dbReference type="OrthoDB" id="6329847at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009423">
        <property type="entry name" value="NDUC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13099:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13099">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06374">
        <property type="entry name" value="NDUF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017834">
        <property type="entry name" value="NADH-UbQ_OxRdtase_b14.5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="13552" checksum="F234EFA72EF47DE7" modified="2021-09-29" version="1">MSSQLSARELLELGDEGRTKSVLTRFWPEVLGTFFGVGVGTFINFQTRRPPFSGIQKHIFLTAGLVAAFTYLQKHRDSYFAEKDAILRHYLELHPEEFQEPPRKKIADIFEPWVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9G7</accession>
    <name>A0A835G9G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate aminotransferase</fullName>
            <ecNumber evidence="13">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_011121</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000310">
        <property type="protein sequence ID" value="KAF9409556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="30"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9409556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="409" mass="46505" checksum="1EC16E18640E4301" modified="2021-09-29" version="1">MGSRFQVVQQGPPIEVFQLNRMFMEDPHPSKINLSIGAYRDEKGQPWVLPVVRKMEKQMANDETLLHEYLPVLGMEQFSAASTAMLLGEDSPAIASGRAFGVQTLSGTGSLRVGAELLNKHLNYTNFYYSVPTWENHHLVFVNSGFTNPRTYRYWDAKARAIDFEGLIEDLRNAPENSVILLHACAHNPTGYDPTHEQWEKIADVMEERKLFPFFDSAYQGFASGDLDQDAWAVRYFVKRGFELICAQSYAKNFGLYNERVGNLAIVVSDPSVVQAMRSQLTWIVRGMYSNPPAHGARVVTNVLTNKQLFDEWKDHIKAMSSRVTEMREALRAELIKLGTPGHWDHIVKQIGLFSYTGLTQKQTEYLIQEYHIYLLKSGRINVCGLNPSNVQYMARAMHDAITKFPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I8</accession>
    <name>A0A835G9I8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_001885</name>
        <name evidence="18" type="ORF">HW555_010041</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000236">
        <property type="protein sequence ID" value="KAF9411058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000881">
        <property type="protein sequence ID" value="KAH9628975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I8"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9411058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9628975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="234" mass="27515" checksum="BB7D8CF315944E58" modified="2021-09-29" version="1">MLVLFHLAVISLYSYAFWYDQKYIDIEYPSKEFEFIPLKARVIFFTFWTLVLQNVYFIISLLNDFFGTNEVTRKPPLIRQVKDVLFSITLCTAFYVVLVFWTFYVFNKEAIFPPEAELKFPKWINHIMHTLILPIILIELLVTRRNFPTKKTGFTVAITMTAIYAGYIHIVYFKYGIWPYPFLYVVSWTTKTLYFIGSAVLGMVFYLFGEKLDSMVSGKSRTAVSHMNGSKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Z6</accession>
    <name>A0A835G9Z6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000309">
        <property type="protein sequence ID" value="KAF9409573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Z6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032784002" description="lysozyme" evidence="9">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9409573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="144" mass="16004" checksum="3139D09E43CCCF72" modified="2021-09-29" version="1">MTRAILFIVALCFIAKSNGKTFTECELVHELRRQGFPEHQLKDCKVCLIEAESSKRTHVVGGSNSDGSHDYGLFQINNRYWCNDGDHPGKGCNIRSTMTSPTLLTGAVRRVIANREDAADFSEKPDPLTRLSAILHSMPNSIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA93</accession>
    <name>A0A835GA93_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="274" mass="31744" checksum="65E41E63485552C8" modified="2021-09-29" version="1" fragment="single">DIKDLVLFTAPVCILSRNLIRMLHLPTIDRFLRALIFCCAYYLQITEEMSVRISQLSSKLRTSNCDRIENEFQDNLADLRLLVAKEYCIILIGGADTKKYHHLGYSKMQKSLSDSDARLFESFVRISIQIVWIALGRKKFHLIELETHRILKTDLFNPVKHRLTLEYMHEMPVAERATLLGRCVRRDRKPKMRSPLMNDVFCHRPIDYRLLGLGVVNYPQLSTRLKYFRMVVAGTEETLMASGYTLGIIGLPRSHFDTMLRPLPPPCDLKSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAW8</accession>
    <name>A0A835GAW8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_010606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with RAB1A and RAB10; in a GTP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAW8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000009">
        <property type="entry name" value="TBC1 domain family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000019">
        <property type="entry name" value="TBC1 domain family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="126"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9410257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="425" mass="48613" checksum="00290375CE4DB70F" modified="2021-09-29" version="1" fragment="single">SETPNLSSLNHFIMTGVYGSFVIVTLGLVMEAGLELYSDKFIESTFIVLAIILNSMASALAFYEYYGDILPSAETMNKGFVSLFFYYSRIKAFEEVLEGDVVDIDKLRKLAFNDEIIVSPGGPTDHPLNISPDSSWSTYFKDNEVLLQIDKDVRRLCPDISFFQSATEFPCEEIVNSNGVKRLHKRVEQSVLKFSTLERRGLGVAKLSNEIRRSDSTQSGDYAPLNEGCEAHWEVVERMLFLYAKLNPGQGYVQGMNEIIGPIYHTFAIDPDKEFRKHAEADCFFCFTNLMAEIRDFFIRTLDESSSGINYVMGRLSDCLKKTDPAVWNLLEIQELRPQYYSFRWLTLLLSQEFSLPDVERIWDSMFADEKRFDFLIFICCAMILLVRNDLLSGDFASNVKLLQNFPPMDVSLILNKAVEISKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBM1</accession>
    <name>A0A835GBM1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBM1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50592" checksum="936E7F2E8B0BFBBA" modified="2021-09-29" version="1">MMDEGHSQGLVRNNYNIVKNRLAGKTLLHVGFAYNIHRKNQKSSVWVCVNKRHGQCGGAVKLINESDNVQMIKGHKPECQPDELKNDIKMLIEDLKKELTTNFGSIQKMYETKIAKLQSEKYSDKIPIFNNIKKAIYRSRNKALKVKKTQFKNPAQVIIPEIFQKHLLFDYNEDGNRIIVFISDIALNEIKNVHHFFCDGTFDCCPSPFKQIYTIHGEIGNNSDETNIVPIFYTLLINKEKGTYEMMFKKIKEALPDFKPLKFTLDFEMSTIVAINNEFPTAKIHGCFVHFQNAVYRRAKSLGLLDHEETTQYVKLCICLAYLPKDEIEDGWLAIMENSIPDDKVTKFNDYFVEQWLEPVNMIEKWCCHKEKHRTTNLVDAWNHRLKNHLGTNPSLLSFLEMVRIDISTYGTAQARLKANNIPVSRRRAAPERMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCK2</accession>
    <name>A0A835GCK2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCK2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="482" mass="56100" checksum="78B0448FCD854C32" modified="2021-09-29" version="1">MGDLCTACMCAGRNLFCIGETGFYHLYSQILNEIQVYDASSFYLKVCWECLARLRRWHHFKERAKQSYTQLRYVHQNNFEPPSPSPSTLQTSEIQNFSCPELVVKDEVDEGQTLKGEDIKTEETHCEPATFVNIIEPRRRKAVKKDTKPIKDKSKKKLKTKSTLPVKKKVKLKKNRSPTPLSIEDDVADSSHPLEDDLEDVPVQNTGEDDKKQVPFVDENTRLNGESKPCRNELQTTPERPQCPECGKSFSSKKTYRYHLNVLHKGQNRYPCPRCGKVYQWKSNLGRHLRTHKARDSGELYCETCDKRFASVATYRQHLRVSRRHVPESDFSFMCNECGKKFVNKTRLRDHIDWEHLHNIKFRCQPCNKPFKCHTSLYVHMQNVHRNKEKKDNLCHVCGKSYQNAAKLKYHIVAMHTSETPYQCTQCSAAFGWYSSLYRHVREVHYKMKVQPKKSKKTKKLDILPSLLTSQVLPPVHQPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCQ5</accession>
    <name>A0A835GCQ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.670">
        <property type="entry name" value="GCM domain, large subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3530">
        <property type="entry name" value="GCM motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039791">
        <property type="entry name" value="GCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036115">
        <property type="entry name" value="GCM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043020">
        <property type="entry name" value="GCM_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043021">
        <property type="entry name" value="GCM_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003902">
        <property type="entry name" value="Tscrpt_reg_GCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414">
        <property type="entry name" value="GLIAL CELLS MISSING RELATED/GLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR GLIAL CELLS MISSING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03615">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90073">
        <property type="entry name" value="GCM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50807">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GCM" evidence="7">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="458" mass="51668" checksum="9ED42F660247185A" modified="2021-09-29" version="1">MHFYSLTSSRTDMAEGGVATPDWDINDAVVPHVAAFDTFGEWCDGHVRRVYPPGCEEARRHASGWAMRNTNNHNVHILKKSCLGVLVCSQRCRLPDGSRVHLRPAICDKARKKQQGKPCPNRLCNGGRLEVLPCRGHCGYPVTHFWRHTDHAIFFQAKGAHDHPRPEAKGASEVRRSLGAGRRVRGLALLLAREAAIADKILTVKPDKQTTQKVCNPHPQPPPLIPDNQRVQLTCTCGPFECSCRWRPEQTVESYATAAWSPPESQYQGYAPPAHPAPPAPTLQPQQHYDPTALPADDIFHPEEIFQLDQPIRLDFPLEEHTLESPPTFADLNGENSRPEESYWMDWQRAAGSSESSQTPSPELFGGYQQSEYCEQAYVPQAYYPEGAQYYPSERTPPMMETQEQRYYRYGQDCSQTNVADLQSWNYTDCAFTTTDMSECKQYFDVQQQAVNGFSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCZ8</accession>
    <name>A0A835GCZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000184">
        <property type="protein sequence ID" value="KAF9412577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="33"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="499" mass="55677" checksum="150635291CA5CBC1" modified="2021-09-29" version="1">MEKCNYEAAPVNNDSDVLNNTIKWKPFLKQLLICSGVWTSMFLYGLCVGAPTMFIPQIRREANSTDIITDDMASWLTSVYGFSGFPFVFILSILTKFVGRRIPFLIAVLDTLAAFTVLYCSTSITHILISEIMQGLFSASQIVITLMILTEYTSPKYRGIFLTVKTATFYWGIWASNAIGTFFHWRKIPLFGIACSLYTILTVMIWPESPYWLASKGRFKECAISHRSLKGCDEEAEKELQMLIDSQKEYIASCGTNHMSTKESIIDFFKTLKSKEFYKPTFLSTITGCLGVFSGKLVFAVYAIDILKKITNSESTAYTAMLVLDGFTVFSMYGGCFLMKRLKRRTLLLVASSIGVVFLFTLSLYLYLISLNVISENKYVSVSLLVAFSIAVSCGPMIMSVSVYGELIPVRSRNLSVCLVALAGKLVTGLALKISPLLFKRFGLHGAFLAFGLSSLVIIIILYKHLPETKDKTLQEISDSINASKKQVTSKLLPNNNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDH8</accession>
    <name>A0A835GDH8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_013637</name>
        <name evidence="4" type="ORF">HW555_008204</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000681">
        <property type="protein sequence ID" value="KAH9632850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDH8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="3">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9632850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="318" mass="36141" checksum="F4B6FD780A08C1FB" modified="2021-09-29" version="1">MPANRTPPASPQLTTPSIPVAASDDSLATPVRFALREASLHQSASAPDLSPQSNVTERNKKRKIDGVDEIASVELTRTMFTTYYSKQESQYEDMMIKINSIIEQNIELKRSVELMSDKYDEFLGRISALEAEKKEDKRLIRQLEDKIELLERTSRATGIEIRNVPKIDSETKDDLCELVSNLGQSLNLEISQSDLRDVHRLKTKEKSSPILVNFNSVILKEKVIKGVKNFNKTKENSEKLNTTHLKLGLSKQPVFVSECLTYKTQKLFYLARTQHKDCGYDFCWTSHGVVYLRKKVGDPQIRVNSEADFEKLRSANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDN3</accession>
    <name>A0A835GDN3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="73" mass="8183" checksum="5027A4DF4121AD55" modified="2021-09-29" version="1">MRDIISGCMPSIELCEPSFLQLLINVLSPSETRCTYLEVCVVEMVHLTSVICIKKLMLSISNSYATCRVQSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFB3</accession>
    <name>A0A835GFB3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000158">
        <property type="protein sequence ID" value="KAF9413478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFB3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123163" checksum="D886CECDCE47A0E5" modified="2021-09-29" version="1">MLVLNVFKKLVRTTRHCTSFHEPNTCPHPIQAQLALNLTNKKYKFCIETDSASAMTVKRKRQIHVVFLSMLTDFIPAILITMIHHNFEGDISNVNDRQLEFIKNVIDDLGFKDSKVTFEAVGSAGDNYAATVKRVIVEGENGKLRMIAKIAPANENMRLRLNAPLTFGNEQIMYQQFLPKLTQLQKQAKIPEEEIIKFPKCYGSNIEAPNEVILLEDLKEKGFVMMDRLKFLSEECVTSVLKNLAVLHSLSYVLKNKEPETFNYFKANLQNLWATLANAPPEELASLESIEEIYMNLMDNEEYKNLIRHKVRDIGPLNVKMSALEAGSKYAVIHHGDAWTTNFMFKYRGEELEQSILIDYQLSKISSPASDLLYMIFNCTDIESRRKNFHNWLDYYHSELDKSLSNHGLKASYVYSRELLDADLKRYGKLGFGSCLLVSSIMTANSEEAAKFKDFFESDTERRADDFLIITMSNRLHKSGVLTGSLNCYCLACDTFLMTHQEAGDHVGTSPHQKNLLAISYSDKFKDEHIRKFQTGYYCEFCNTLLPTASKVNLHVTDDEHVKNKGTCLLKSRGAGVAAFDNIFIEENAWHGLNDSVCSICNEEFDDGVKHKASATHSLNLVLKDVQFGAANAIYRQIDDTSLQCLTCNKLLVASKIKAHSDDAQHCELYDKHRVVSNGVDHKVENKINKEENQQKAGDSPIIELQNGLKKTNINENKPTESKTKILESITKYQSAGININLEIETAYCKKCSQVVKFNCTDIEKHISEHSTNGPVDNALQYPSNPDQNLNRVDIKDKTAQPSDNSIEIEEKIKALADNSNGENVESEKDEDSSDEDVENEKEFAKINNITYNQSNKQSYCRVCEVHLPANLKSMKEHVTGANHKKLTRSSSTCVPQIKNPTMLIKKKTEDFIESLYDVESMFDSLSIVNEEYCISKNSLTFLTVSQSRVRCLLCDVTLPPYSDTDDHIKTRSHLSKFIEVPVVVSVENEFIREVKRGLYHCGYCELVVSSWADMEKHLECSDHKDNRRRGEQRLITRLPGLQNYKLQKAIEAMTLRRLFNIGLFMLNLWMLWQTSSSAGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFF0</accession>
    <name>A0A835GFF0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000142">
        <property type="protein sequence ID" value="KAF9414117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="65" mass="7505" checksum="1911DC5F978CFB36" modified="2021-09-29" version="1" fragment="single">ELRKRKAKTTGKKAALIARLEAYDLNFNIVTEDNKNDVQMITPPNEHYKDINSKTILPAFTKHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFX3</accession>
    <name>A0A835GFX3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit beta</fullName>
            <ecNumber evidence="15">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_003405</name>
        <name evidence="17" type="ORF">HW555_007855</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="15"/>
    <dbReference type="EMBL" id="JACKWZ010000142">
        <property type="protein sequence ID" value="KAF9414096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000537">
        <property type="protein sequence ID" value="KAH9635681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFX3"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="188"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9414096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9635681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="516" mass="55100" checksum="76224CBD6667A313" modified="2021-09-29" version="1">MLGAVSRVGSGLLAVKSAAEKTLTECGKIATVSAINKRDYAAKAAAGKGQGKVVAVIGAVVDVQFEDNLPPILNALEVQNRQPRLVLEVAQHLGENTVRTIAMDGTEGLVRGQPVHDCGSPIRIPVGAETLGRIINVIGEPIDERGPIPTDKTAAIHAEAPEFVDMSVQQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVISLKDKTSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIIGAEHYNVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVARARKIQRFLSQPFQVAEVFTGHAGKLVPLEETIKGFSKILQGEYDHLPEVAFYMVGPIEEVIAKAETLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGQ5</accession>
    <name>A0A835GGQ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tensin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033929">
        <property type="entry name" value="Tensin_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="C2 tensin-type" evidence="6">
        <location>
            <begin position="243"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="918"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1173" mass="126737" checksum="FC8E562334AB58AD" modified="2021-09-29" version="1">MRGRCSRGADAARALHRLAFALWRAVFYLQRAPERAERRSRSLAAHTRAHTASRAVSAPATPASTTFSRDQGGSRSASYPGGPGSRLDLCYVAERMLALHLPERDAHAEAQAAHMLTNKHGEHFMVFEVSGGDGAGGVGAARSVFGRARSLGWAGDLAPPLERLCAACKHIESWLAAHPKNVAILLAWGNRERLGVLVAAYMHYSAICGAPEHALDRYAMRRYLDDRVPVFQLPSNKRYIDTFAGLLAGQIRVNAAPLHLTHVSVAGSLASPATPTIAFLKIYENFVCLYMVNGGGWTVGVGRLALRGDVVVRAYRRSAQAAARSSQRHLVFACQFHTCAVADHTLSFTKQQLDHAVHDPSFPSDGAVELVFLRGEGGGGAAPAPTPAAPLRAAPDALARADSLEHLRPLSTLTDDDPGENNGSAEGSGSGGEAGDGNEAAHTFGPLDGSIYATVVRAGGGGPSSPLSASMDSGISSAGRRAAPSPPDELDALLGDMLRTVSALPDPPPAPHTPQPQSHADRPPDIPYHARADSAPFTYGAPGLRPGMLRAPNRLASPELVRRALGGDRNYRPIEDDDDERTVTPEHPSPRTPLSPRTLKKLTHEEVTTTTAAAPPPASPIRNGRWLNGEVEWAERPASAAAVRKTPPENGTWRSASTLGWHESSRAREPRRSESSVEGSSGLTWLQRQQQKLRERKEARERVARLPLEWDTTSSRHVRRSASHRVDGYTSDTTAFADDDEDFSVPLHVNTRTPLRTDHTSPPAPDRTSSRKFMYEKMTMREWSTTSTPNSTPAPGLLSLAEPSNTDTVDRVESWSRAESRTESRAGTPAFPTHPRTPYPPTPTPSLSARPPRSPSVTRYNMFDLEDMRKEREISPESEYRIYNGSSGSRRSSVSGTAEPQHVAPDRVRFARDTSHYWYKPNISRDDAVSALLQLEEGAFIVRDSNSFPGAFGLAVRAGGAGGVRHFLIEPTARGVRLRGCPDEPVFSSLSALVYQHTVTPLALPVPLRLPDRDPWTGGSANAAARALLATGAACHVLLLGSENTEALTGPAAVKRAVTNILNKKAPAHVVHFKVFGGGITLTDAARKLFFRRHYPATGVSYAGLDPDERRYTHTDNNTQLEKRIFAFVARASSSADNQCHVFAELEPEQPATAIVNFVNKALLGSSQKKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIG0</accession>
    <name>A0A835GIG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="86"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="19392" checksum="12F252C05B6B0E8A" modified="2021-09-29" version="1">MPQDVSGTLEIFTHRGNSVHEDSSYDDSDDEPLASKRKRANSTRESVPNSAPTWRKCEPSYSSAPQRTSQVNEKKNYVCEELKILNPVQIFEKLFDDDIIDLIVSNSTVYAKQHNRHEFELVPCDLKKFMGILILSGYHKLPREPMYWSLDEDNGVELVSKAMSRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIK9</accession>
    <name>A0A835GIK9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIK9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="45" mass="5113" checksum="215EF702603E7AB3" modified="2021-09-29" version="1" fragment="single">APRPRKRPFACIDYVSACLASTSKEFDRPAFQVNEHYEDTHSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ45</accession>
    <name>A0A835GJ45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000084">
        <property type="protein sequence ID" value="KAF9416760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000025">
        <property type="entry name" value="Neuronal PAS domain protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000054">
        <property type="entry name" value="Trachealess, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF26">
        <property type="entry name" value="PROTEIN TRACHEALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="671" mass="73054" checksum="CC08C3D944D485C0" modified="2021-09-29" version="1">MGAQNRRTAIGLAMELFEQHQGTHILQSLDGFALSVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYVHQADHAEIAEQLGLSLTGRPGQAGLNSPASGSEEGSQHGTNNPDVSSQMSLAASGSLYRGMDRAFCVRMKSTLTKRGCHFKSSGYRVVLMLIPFPIAESLQRYLLGMVALAIALPPPSVHEIRLESDMFVTRINFDFRIAHCEPSRVSELLGYTAEELTGKNLYALCHGEDANKLRKCHVDLMNKGQVLTHYYRIMNKLGGYTWMQTCATVVCSSKNAEEQNIICVNYVISGREYPNTVMDCCQLEESVQGVKREETTGDPENGPPDTDNSGAPPPPPRHQAERTEPPTNTDSASSAPVPTSEVTHLTRLSDAQPLPLHTNTERTSPMPARRLKKQRDISKTNLAIPEGGSDATSVRDLENAMSKHLPSVALDGKEISHRPTDFSTDALLKQQQQKSTIQWIGTQNHHLNPLNRQIPANHTSTPASALLRQLYANRESVIRSNFLGDGRTGGYYSGDGQSGPLPTPPGSEGSGYGEQLGHKGTDIGSLAYGGYADYHSAMTPPGSVSPRDKQQYALPYDNSAYSEALRHSYLGEAPLPLKPQAYSAVPGALDYASSLDQSQFFHPPSSFHLYHPQAHSAHASHSHQPDKSAPPNTNWYSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJY1</accession>
    <name>A0A835GJY1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJY1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="769"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1261" mass="143512" checksum="04DE8992E2EFD300" modified="2021-09-29" version="1">MTSLVATTSISAVDDINLIKELNCYKYRQRRHVLKSKENTIRHKCNKVLKRKLRKYKLRQDGQEDQDILDVSKILVSSLTIRSPSNQKDPYLCEDSEFEDWRPKNYLFKMVRRKPVKINDTLKNSNTEVDIQDDVIIDSPLAVSSQEKKQTNAFKLLMDSRNKSLGCNSPGKDKSDENIDTTEVIERKNLKAKRQLLLQKMAEAKGSLKNKESEEFQDNIIKEQMEKRAKRLKSMIFKEKPDKEKDNKVANNNNTKKKNKSNTFKIVDIFNTVEDNAIISPVKKSISKEDEDFLSKLSPSLKKKESMLSYFKKIDKDTECSPNSENDNLIKVKLQPRNKKKSKKKKLSLKKDSLEEIDLSGAIKEQEENVNGEVTKILEDKVVDEAIINNKVNEFNQIQQKSKDKTLATISVNIPDITLDKMILNVNSDSDKVNNESQKRKRTSKLDMKLDCENSKTTFNSDSRPKRSVKRPVKYVDDACLSSSDEDLHIFTPKKRSTLTVQTDQPPDELKPVKPKPEKKVEKVLKDVTSKKPTKLAPIFTSKQTDPAALEAKQKFLQSGVPDKLKKQIQQQKVNSIPENSFPVVVHVQQSTATSEDNQLVIKIPLMNTETAKKTVHYLMKIKLVTVNQDISYYSVDTKSKKSTQAMLQTIKKMHPKFPVYRTYRYLRSKGKGEIKDCSYVDVDNSIEVLGDMVDVINDSPDRLNWTDKYKAITTKQIIGNFETLKELRRWLILWTENQIKSKAKGKANSDSSDYYESEPDSRDSIKSTNNLLILVGPTGCGKTASIYAVAADLAMKVIEVNASSRRTGKIMLQDLQEATQSHKVNRGTGNSDNSQKSQEKQQTDLPKHSKKRGRPKKTIEEEKSKEPIVKNEVLSGTTLSQESTRTDSSLILIDDADIVFDQDDGFTSAIMQLVQSSKRPVILITSSLVCPHLQRFLHNAKILKMSPLLPRILGTWLDIMCLADSGMCWPGVGAKFLNYFKGDIRKTINYLQFCLPKVASSEEEAASQNVDLYKNHIDEESSCMSWADNDDAEGRTSAPGDVDVNTIWTVFASKHSNLKNLTYPAQLFNTWWSMPSLLTAAPTIDLPSQKCNNVQKKKASLELEAIANAADAFSLSDYYSHINQDTERNITSQPWYCPESHSVSERENPDRYHKEYEIMSDICHTILTGSIATAQDVLSCDRKTNIMLDRRALALDYWSSCRTICRLEKSKNDSNTKRNNRFCHYLKSLSVLCKSDTFDNLCDSLCSNEGTELNINNFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK02</accession>
    <name>A0A835GK02_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Disheveled-associated activator of morphogenesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK02"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="516"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="893"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113214" checksum="66F07DFCE07AEB2B" modified="2021-09-29" version="1">MLFIAWCWKLRLPSNSCSQEELDLTAVNKAAMMALPAAKKWQIYCSRRPPPGQPPPLATAPQLEEYIKALNEIADAFASQDGVPPAEACALVDGLKTALRTRAHSFVLRFIKQGGLGSLLDALQKAPRDDALTRHNLIAAIKALMNNSTGRAHVLAHPTSIDLIAQSLDTENVKTKVAALEILGAVCLVPGGHKKVLEAMVHYQKYAGSTGAYRDDLGLKTAIMSFVNAVLNYGPGEESLEFRLHLRYELLMLGIQPVIEKLRKYENETLDRHIEFFEMIRNEDERELARRFDKEHVDTKSATSMFELLRRKLSHTAAYPHLLSMLEHLLLLPHLRSGRSSFRDQCREIVHLLAKEEELVAARTKAENLEKENVDLATELAKKEKQVDEQSQEREELEGVVSRLKERLERETAAHMECTERARASATRALLLEQQLNQERAERARFEKLVSEGSIPDDAKVSNLKSAVIETACTIPPPPPPPAVCAPPLPPAPPAPAPPPAPMAPMAPAIAPPRAKKNVPTPGNPLKSFNWSKLPDTKLHGTIWQELDDTKLYNAMDLHTIDKMFCAYQKNGVQNEGSVEDLRQLGSKPRTKILTVIDGRRAQNCTILLSKLKMTDEEICRAILRMDSGEQLPIDMVEQLVKFTPSAEEAALLEEHQDELESMARADRFLYEISKIPHYSQRVRLLLFKKKFGAASGEATARAAVVLRAARDMTRSRRLRALLEVVLALGNYMNRGARGNASGFRLSSLNKLADTKSSVSRNTTLLHYLFKDILLLEEDLPHVRAAAKVCVEQLEKDVGALRTGLREVARELEYHAALPNRSHNDMFLPVMRDFHAHAVCSFTQLEDLFQDMKSRLEACAHAFGEEASASPEQLFGALDVFLTQLGDARADCDAARRRRDDEERRTRHEQELKKRTMERKQASSLLSSVGKSLGKSNGNADCNGHSDSSRDGTLTNGQKGEFDDLISALRTGDVFGDDVAKFKRSRKASKVSHKGRDSPPRGVCREDSRERQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK79</accession>
    <name>A0A835GK79_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aconitate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK79"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="9">
        <location>
            <begin position="68"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="44300" checksum="18702A214F60C5FB" modified="2021-09-29" version="1">MAATNNPYQHLLKTIQIDGKPFKYYDVTGLGEKYDRLPYSIRVLLESCVRNCDGFQVLQKDVQNVLEWETNQAVEGGVEIAFKPARVILQDLTGVPAVVDFAAMRDAVKDLGGDPQKINPICPADLVIDHSVQVDFARSPDALNKNQELEFERNKERFQFLKWGAQAFDNMLIVPPGSGIVHQVNLEYLARVVFSKDLLHPDSVVGTDSHTTMINGLGVVGWGVGGIEAEAVMLGQAISMLLPKVVGYKLVGELNPLATSTDLVLTITKHLRSLGVVGKFVEFYGPGVSALSIADRATVANMCPEFGATVAHFPVDERSLQYLCQTNRSKEKIAIIEAYLRATKQFRDYNNPAQDPIFSEVVELDLSTVVTSVSGPKRPQDRVSVSVMKKDFQDCLTNKVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKE2</accession>
    <name>A0A835GKE2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="546" mass="63330" checksum="77DC9F35B1871C0B" modified="2021-09-29" version="1" fragment="single">IVQWFHQSEVAADQLRNPQKAENVLNLNDVAGVDEIEKTIENLSNLEQGKKRPHKPTVSDLDSFDIDAIRNKINEFYIVRKQVPTLKTLLVELRESFGFNGCRETLSHLLLSNGYEFKNERSLLIERYDISSWRHRFLRTMALKRREGKCLDKVHLQVEAVKHISTGKRYIIVHAGTEKGPVSNSLLVLSTKSKMADYHQDMNAVNFNKLLREKLIPNLNEPSTSHHIVAAKNKRRLKLENIILKSTLKIVENKKFKAVPEKFMFRQDWNQSLHTDDDNLFAESCAVIDLKEPSEESRVILNECTGELTINNENNENETQNIQVKENEGDSHKKIYPLPVITTPTQIKITEPDSFTDDTISLQPTTSRQIEMQISKTIIEPQPSTSKQINPNKTISVVSNIPFSEYLKQKLPDFPQRQGKRQIERTIFALTSNQYVDKIREKQLKKQEEDAAKEERTRLREEKKSQKENDVPNKKPKNKTKKTATNKIINSQDESNKLLENKKNRCVTCCDYCLNPITRRVILCSLCNNFMRIVYHYLTGFIFLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLI4</accession>
    <name>A0A835GLI4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLI4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="113"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="527" mass="59642" checksum="6FEC4373825E3DDE" modified="2021-09-29" version="1">MVAFPSTVLETTEEEVTTEYYAPQDLIIGNTVFILGRRFLICNCDDFTRKYYSAMLNLQQPEPVKVHKEEKKEFPKSIPPHIGIGAPEDTLQSCYGLIPKPPHKDIIKYNLNANKYLRYLCELDWVHPEDDGRKFVMSYSLADGSIKIGEIPRRNSGIREGKFLQAMKLETPESDHNFPTYFTPERFYIGAIIPVFKHRFRIIGCDLFVYRYMTANPEKFPREVIDNVRNYHLREGNLKDELTTAFREEQSAETRAQLAKIGSAAVAEPSAMERCLAALDVVEGSTSPPRPPTPPMTTDRISYDESLRVTRQSKPTCENITPLKGILKSGAARDDHQKVVCFSGPSADEHREARLQKPTYPPGQQPHYNEDEDFCDQFKDPDAAERAERRAHEVCPYEIVPSSQISNAIGDDKVEKPQLPGYLGTYGVDCKQVPEYMKLAPDAYEQVKKLRRDVPVISPAATRVADYPRLPPDSVDTCVHPPSTDTGACAPRKEEDVSFACRHVEAKKPCCDPLERKTDPTAVLPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM54</accession>
    <name>A0A835GM54_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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            <end position="86"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2130" mass="242046" checksum="AAAB3064D554AC1B" modified="2021-09-29" version="1">MNVNYDRVCRLCLSSRGELLPIFPTTSSDDSEPPVLALKIKDCVSIQINENDDLPTNVCRKCMDNVNNWHVFKTVCERTQNKLQSLKDGSQLEEVKIKSEPLSDEAYDDGVVIDGSYPVIENAGGSNKVQPEGPPILASLGLTPRSDKTCVDPRMDWHRVHAILDMVQDNEVIDSLQTKEECDVLQHSDHDSDTEAELQQEIDDDFVDCKTGYICKNKKVIAKAPKLSTAVNNARIKEAFKLGKRKSTVSKHCSRPKNAWQLLFTDDLLELIVASTNENMVANGRGFSESTTVNEIKTLIGILYLHGIMRPTHPKCSDLWSSDCGVPCIRNAMEYERFKFLLQNISFDKKDGDSITQYDIMKRMRKVFEIFAMNCRTSHEIENIAVIDEIIVPVYGPCPFRYDIDKKPLKRGIKMVLLVDSSSFYVSNLDVITDSYFGAEEMTKKLVQHLAGTGRSIVMDSWFTSPSLIDNLRNEYQLFSIAALNPDSDMIPPLFLSQYRKCRTFMSGFVDHEVSLTSYVNTEGKSINVLTNVPKYYRKGHINHTTVVSVYKKNQSAVEVVDVLMHYYTTMQHTNDWTLSIFFTLLNIATVNAQVLWCSQNNNITQRRLFIKELALSLLEVEDDRIFISPILNTEENRNNFSLVQNTVQPYYKNRRRCKICVRTTKKDRRTKQFCVKCGQFICKEHSGAESENNDEDEEEANEPEPAQTYPKMPHMPEVSITVMRPTGETLHARQGIHQLASKDCLVCGRSYRYSHNARRHELTAHSFDRYTNKITPKKTLTHLQPKLRPNPFNPKARMMPKPISHKMQFMNKNIPAKIMPVNKVITPQKPIPIKSSKTTANNLPYPLRIKALKDLQIKKKEPQILKTLLTSKPEVLVSEPEILNSGPESPETLISEPEIASFQVEAILTEPDADAYEPQDAQQGDEEGDEDMNNQGQHYDTVDMDSENEIEIARQQGMEQDGEDNLDGEENIEQGDEDNNMEGGQSDNEKDGNDDTAESQENMEEEDSMDIKPETECHMKDDEGQEDREHEESEMNHNENEEEDDDDDLPMSLAPVVEINEGLQGNSFNSEVNEDDEELDETADPNETLEEEEPEPKVLDPDKTYVTKTQRDFIQKYRDIIQQINTKRCLCCDREHPRRKAVIQHLQKNGHKVPKHTCYNCVITFGHIGALLSHMRSNTCTNLWKIIYNENGITDDQVLEDEPKEVKVQYKDIFNARSYACKLCPAKFQLKQFIMKHVLDTHEDGQSRVPLSCVHCRARFKDKSLLKKHIRKGDCTVYVACDLCSEKFVNMQDFNDHALAVHADSFDQSDNQSKCVDGRPTDCPLCGKKNSSYPNLVKHLKIIHSEEKPHYCQHCDSKFEQATDLNKHIYMEHSDRTLGMVSEPDMSIVKEEAEEYHYSCTECNAIFETVDAWTDHQVAEHNQIAHHCDQCEKKFLRPSELAEHKNTHLRVKFYPCSVCPNSYGTPQKLSEHVQEAHAGLGPVVPAEAEFFCDICIRSFKSRQAYSNHMRIHAKVPTTNRKPGVVKGSAPQIVVKPIKQYPVAQPGFSWFKPNYNIPNAPYSCDICGKGFMHKKNIWKHKKVLHADILADRHDSEENTMQASTEEEEFNPDENGAILSTPQFNSFNFTNFPNNVQQSTPETMPYSCELCFKRFPLKTSLWKHKRAKHGIVNPGTSGSNDTAAASASGGEGSSRSSCTICRITFSDKKSYYRHRKNVHKSTVQMCKICGKPLSSTLELYEHLKAAHARELLGYNANQGSSKSQDMTQEVEPDYENDQESADPSVDYQARYPCDTCGKQFVGLLALQNHQCINQMPAQPQTFDCEICHKSYTSISALKSHRGWHLRSPDGKAAANNSGLWMPQHKVTSKISKHEVIDPSQLAKVTHTATPVSASVAKRRLPPEVEVTVVNPNKKLRSDDSVDMDTQNSGSIEDRYCTICDKEFTKRAAYQRHMDEVHQPNSVFCAVCDKSFTRKSTLLIHMKKHYESGEGSSSATGQGDDDMFSCDLCGAQYDNDQALRAHRARHHGEEEDSAEESDDGNVPVPPPGEFTCAQCGDGVATPRDLIAHRTMHATPTKFFCNICKVYFARALDLSSHTRARHADNEKVFFPCAMCDRFYMNKKSLQRHIEMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMB3</accession>
    <name>A0A835GMB3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain roadblock</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_011905</name>
        <name evidence="12" type="ORF">HW555_003280</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000171">
        <property type="protein sequence ID" value="KAH9642858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMB3"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000009">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="11">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9642858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10900" checksum="A2E8DE9A76F4F98F" modified="2021-09-29" version="1">MATEVEDTIKRIQAHKGVMGVIIVNHEGIPIKSSLDNATSVLYSGLIGQLTEKAKNVVREMDTTNELTFLRVRSRRHEILIAPDREFILIVIQNTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMN3</accession>
    <name>A0A835GMN3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF56">
        <property type="entry name" value="LP08842P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="6">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="13972" checksum="4C3655BAACB62F52" modified="2021-09-29" version="1">MNIGSATATIQNVAVTGCEENAKECILKRNTNATFSIDFTPVKEVKEIQTIVHGVIMNLPVPFPLPQPDACKDNGLTCPLPAGQPQKYHTTMPILKSYPKVKVDVKWELKDEASEDLVCILIPARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMS2</accession>
    <name>A0A835GMS2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMS2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF16">
        <property type="entry name" value="LP07342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032991197" description="DUF243 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="3">
        <location>
            <begin position="118"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="321" mass="30474" checksum="5434B312EDA9DF94" modified="2021-09-29" version="1">MRAFMVLACVALAYGRPEPPVGYSYSAPSSGGFSGGHRGGHSGGHSGGISLGGGHSGGGLSFGGGHSGGGLSFGGGHSSGGLSFGSGSIGGGSIGGGSIGGGFGGDDAGYAGGYSGGALVQKHIYVHVPPPEPVEQRQPRIPEVAPPQKHYKIIFIKAPTPPTPTAPIIPVQPQNEEKTLVYVLVKKPEEQPDIVIPTPAPTQPSKPEVYFIKYQTQKEGGIGGGDAGGIGGGISGGIGGGIGGGALGGGIGGGVSGGDLGGISISSGSGSGIGGGAGGHGGIEISGDFGASGGDDSGSDGHSGATSSQYGPPGHVAGPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMY9</accession>
    <name>A0A835GMY9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033054072" evidence="2">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="266" mass="27538" checksum="524DED6AE1E6AC0A" modified="2021-09-29" version="1">MKVFVITLLCAIASCAAGGSVAWPGAIAVSSPVLKTIIPGETKTTAYSTTQYINAVPTSYAFAQPQLAYHGVPQYNSFASLQPAYYPIAAHSYIPTANVFYPSAASFSPVLASGFPSAPGYPSAPESSPAPAPAYPGSSPSPPSSPAGDADSAVVDSADYNADQQRQQEPASTPSPQPPAPEPTQPAPQFPPFPPSNTFPNFPNFPQLPQGSGQIPSFPQLPQLPVPQYPDNIYLQGPSSPPSSFPGSNNEDKGLNDADTVSVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNW3</accession>
    <name>A0A835GNW3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNW3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="294" mass="30796" checksum="F435CCFC8ADB28C9" modified="2021-09-29" version="1">MMNTKIVRVVAACAAWSASDGMAAHGRARRPWLWLAAAAVALVPLLATAIAADVIFRVPEVLVRHAAASKPVGTGRGNTSRGNESERWAGAAGDDSLLEVRYEEYFVEHDVSTAAARHAAANLNVEDSKLPHTHKSTQSQHHPPDAARLRRMQRARAGVLRDARAGRPLLLRAPLRARALPLAAPHLLRGRAPLPPPGARLRAVRASARLLLPSQAGRAMEEHPVGVEPRGSERAVPAGGGGAGGGGAPVTSAGAAPGARACLRLTTSAWTNSRHCVPPPTPATTATLIFSHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPC6</accession>
    <name>A0A835GPC6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPC6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="368" mass="41983" checksum="081661E658CCE8DC" modified="2021-09-29" version="1" fragment="single">MESNYERADNSNLPKIDPFMVALFFKNNADYYAAELKNVKTAVSARESYGDDAVGYVQLYRDNGICTVKCKMCPEHKVRTKAYNVTLIVNENDGEIISCECHDCAASAGGCKHAVAFLMWVHRRSEEPACTSVECYWKKPALSRVGTTLKFITIEQMTKTLVPHRPSTSALCEDFILEAKKRKINKCELLKYQNDFVHSDITRYSLRSFMVNLPQETKNDVGLLLSVMKSAFTSDIIKNIEEATRQQNKTNFWYELRYGRITASKAHEVSVCHTTDGALVATIMGAKIPDTVAMKRGRILELSVQLQMYATGLHKCYFCIADSNFEHTQKVDIMLENYDEDFVNNLINKLTFFWKGNIYPILLRNTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR80</accession>
    <name>A0A835GR80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_000772</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9424063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="638" mass="71153" checksum="46DE32D635D96A01" modified="2021-09-29" version="1">MDSNNVNVVENVSRENPGFDSAPEYDDRSKKIPPPEFNGTDLPGKAEVGSAAEIERPTWDNQYQFLMSCIATSVGLGNVWRFPFIAYQNGGGAFLIPYIIVLILIGKPMYYLETALGQFSSSNCVKVWALSPAMKGTGYAQALSAFYVVSYYMSIVGLCLYYLIMSFQSVLPWSVCQPEWVDCVPSGEVANLSLIQNRPITSAELYFTKTILRQSDGIDDGIGTPIWDLTLSLLVSWFIIFVIVAKGIKSSGKAAYFLALFPYVVLLILLIRAVTLPGADKGILFFITPQWTKLLELRVWYAATTQVFFSLSTCSGALIMFSSFNKFSQNVYRDSMIVTTLDTFTSLISGITIFGILGNLAFQMGEDDISTIIKSGGSSLAFVSYPDAIAQSPFVPQLFSSLFFLMMAVLGVGSGVALFSTVNTIFLDAFPKVPTIVTSAVMCSACFLVGLVYVTPGGQYILELVDHYGGTFMRLFAAIVEIIGVFWIYGLENMCLDIEYMLGLKTSVYWRFCWGIVTPLMMMTVFFYALVTSDQLKFGDYIYPDGAYLAGSFLQYFGIALVPLFMAVTFWKYRTSTFVETIKTSFKAKKTYGPSIPQKKAEWREFRSNAKYERNLMRKNWFHHVGLSLIGGYRRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTG7</accession>
    <name>A0A835GTG7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin-4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTG7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47538">
        <property type="entry name" value="PERILIPIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47538:SF1">
        <property type="entry name" value="PERILIPIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="908"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1042" mass="103801" checksum="2DB3E6471A530DC3" modified="2021-09-29" version="1" fragment="single">IPGAFRSIGEKTASLFDRKKKDAEQAAVEKAQEVAHVVEDQVKKAGEIIGGAQQTATNAASTANDAKHSAIDALDKELSKVSLAAGEAQDAASKALADGKKVVDTTKDTLATTAENTKKAAESAFNTTKDTVSSTIQSTVDTTQKVAQSAIDTGKTYATTARDTAQSTLQMAYDASIGAASSAYGVGLSYLESAKDTVASTVDSTKKTAQSTIETGKTYVDSAKDSVTNTVHTTVDATKNAAAAAVEKGTTMIGTAKETVASSISTTVDTTKNVAAAAVDKGTSLIGTAKDTVASTVDTSKSVAAAAVDKGTSLFGTAKDTVTSTAQSTVDSTKNAAASAVDQSTTFIGAAKDNVTSTVQSTVDTSKNVASAAVDKGSSLIGSAKDTVANTVNATVDTTRNVAAAAVEKGTAAFGTAKDTVASTVQATVDTTKNVAAAAVEKGTTAIGTAKNTVANTVHTTVDTTKNVAAAVVEKGTTAIGTAKDTVANTVHATVDTTKNVAAAAIEKGSTAIGTAKDTVANTVHATVDTTKNVAAAVVEKGTNAIGTAKDTVANTVHATVDTTKNVAASVVEKGTTAIGTAKDTVTNTVHATVDTTKNVAAAVVEKGTAAIGTAKDTVANTVQATVDTTKNLAAAVVDKGTNAIGTAKETVANSVHSTIDTTKDVAAAAVEKSSSIIGSAKDTVASTVHSTVDTTKNVAASAVEKGSSLIGSAKDTVAQTLDTTKQAAASAVGTGVSYAASAKDTLANTVHSTVDTTKSLASSAVDKGASIVGGAKDTVAHTLDSTKQAAASVTGTGLSYATSAKDTLANTIHSTVDATKNVASSAVDKSATFVGSAKDSLASTVDSAKNVAAGAVDTSVSFLGNAKDSVSSTVLGTVDTTKNVAASVFDKGVNMVGSAKDTINTTVDATKKAAEDAKAQAAKAAEDAKEKARLAAKAAEEEAKRVANAAVEESKKAAEKAAADASNAINSTVDNTLKRVENAADEGIKNASTVVDSKIKDADKYLNEKRDNLLTNLSSAVNEASTGASGLLSKGLTAFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTY9</accession>
    <name>A0A835GTY9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9422924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="158" mass="18068" checksum="F47823936EDD89ED" modified="2021-09-29" version="1">MVFVSKTIVERTQQASRQSVKEGEYMLQVYVRSDNLAGVLISDHEYPNRVAHTLITKILDEFTAAVPATQWPTGTEDRIDFHVLPEYLTKYQNPREADALTKIQNDLDETKIILHDTIKAVLERGEKLDDVVAKTESLSMQSKLFYKTARKTNSCCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU01</accession>
    <name>A0A835GU01_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU01"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047119">
        <property type="entry name" value="FOXN2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962:SF22">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="354" mass="38514" checksum="0D2A8F3A6ABB75F4" modified="2021-09-29" version="1">MKMAPMRGERGGSPARGARASLPLPRRLIRQIARHVASSGRSLRRLEVSGRVIDNFDDIEDASDESDMEQPQPAVACGGNAGNLPPADHDDDLTSLSWLQDRNLLRGINLTKSGVDMEDTKMVDNQIIVKREIKTPPPVARVPSPPRTPCKAPPSPPANTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFRHAPQGWKNSVRHNLSLNKCFHKVAAAPGLGKGSLWTVDPQHRASLLQAFGRQPIPAVGDVVENPEPVQENGTRVSLLARRLADPEPGADEYLAAATVLAMKYGPAVLDQLPPAAHLVISRCARDEHSYSGGEERRTAEALLNLAGVRSEPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU74</accession>
    <name>A0A835GU74_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU74"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000032">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="106"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="500" mass="55030" checksum="4E76DAE36C16A837" modified="2021-09-29" version="1">MPKVSVKVKWGKEMYPGVEVNTDDEPVVFKAQIFALTGVQPERQKVVCKGVTLRDDSWANFKLSNNALVLVMGSKEEDVPSAPVEQTRFVEDMNESELATALDLPEGLINLGNTCYMNATVQCLKTVPELKNALLSYDKSSGGGTAGELTSALSDTMSALEGGGAGACAGAAAKLLRALHATAPRFAERGPGGGLAQQDASECWTEIIRALQARLPSAPNAPANRSSVIEQYFGGTLDVELVCSEAEEPPTRSTETFLQLSCFISQDVKYLQSGLRSKMSEQITKLSQTLGRDAIYTKTSKISRLPAYLTVQFVRFYYKEKESINAKILKDVKFPLELDVYELCSPELQERLMPMRNKFKEYEDANVESSLSSKNHGDSSKEIKKKDPMRSVPYWFPNDVGSNNSGYYRLQAVLTHRGRSSSSGHYVAWVARGDSWLRCDDDAVTPVTEEEVLKLSGGGDWHCAYLLLYGPKILQVPEVDDKPEPMITEHDDEDPPIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUG8</accession>
    <name>A0A835GUG8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUG8"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="470"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="632" mass="67398" checksum="3E097FF8BF4A4AA3" modified="2021-09-29" version="1">MSSPSKLRSKRQTRYKRLLHKRLPITKWLPEYNSEKALADLIAGITVGLTVIPQALAYATLAGLSPQDGLYSSFMGCFVYIVFGSCKDITLGPTALLALMTYQQIQGRNPDYAVLLCFLSGVVQLGMGLLHLGVLIDFISVPVTVGFTSATSVIIAVSQLKGLLGLQFKSGGFLDTVRKVITNLPNARLADSTLGISCIVLLLLMRKMKDIKLPASQKGLKKTLWLLSTSRNAIVVVGCSLAAFFFEKYSTQPFKLTGTVKDGLPSLRWPPFSTAVNGRYVGFTEMCSDLGSSIFIVPIIAVLGNVAIAKAFASGESVDATQELITLSLANIFGSFAGAMPITGSFSRSAVNHASGVATQFGSIYTGVLVLLALSLLTPYFYFIPKAALASVVICAVIFMIEYEVVKPMWRSRRADLLPAFATFALCLSVGVELGILAGVAVNVILLLYPSARPQLEAEIVTNASGFSYVLVTVGNSLYFPGVEYIRQYVERAAKKQGGCSMPVVIDCRYVLGADFTAAKGICALSSSLAARGQPLVLLSPRACVASVFSGAGSNVVVVLTHAELDSTLHSLTGQIPLQLTSKEHTPPPNYDSLKQSDDDVTEVVIVDDQNSTPLLCKNGTALSHANGGNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GW77</accession>
    <name>A0A835GW77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GW77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="31156" checksum="A49430F171902EEF" modified="2021-09-29" version="1" fragment="single">CYKTYITASLIVDMSKSTKLLYVKGMNLSESESDDDQWDDKKLNDAYDKAVRIANVEVAKRVAMSTNTQGLNSDLEFFPKKEKLATKSTKKKSVSPFVNTNGIGDDRSKETGWKPSMPCRLVYADDGLEYEAVIVRIVDDNDCVVKYLGYDNQELVSIDSLKPSLGKEARAQQIRDARREQTEESYGSLSPNVDGVECSDRVPSPDSIEMPPIPNLSMLRNQLGSMEMPMPPPPMAFSMDRSDTEEQAISSMLLSWYMSGYYTGLYQGLKRAKDGRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KX22</accession>
    <name>A0A835KX22_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008436</name>
        <name evidence="5" type="ORF">HW555_013392</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000637">
        <property type="protein sequence ID" value="KAF9406132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KX22"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="44914" checksum="80017D413F68B653" modified="2021-09-29" version="1">MSVWNPELKNVVDDQSEFLKDFPKKSFSKIDSTSKLQVIQALDNGQCKSDIAREYGVHPQTILSIYKQKDAIIKKYNQKYNLLKEICSLNLEQNLLDWFEQQFKIGNFITEDQLRAKAQDILKGLSEKFTSIDDWLLSFRTRHNISKYSSDDMYGEKAKEEWRKFLANSESKDVYVGGVCALSHNLDYNSYLNGQHAESYVSLLLLVNALGTDKKEVVVAGKESMETEIHVRSLPVSYYYCINSQINWFIIQSYLTKWNNELASKGNHITLVLDVPESIINTMKFENIRVLSATGLSYVTNILEKVVECFKYHYRRLQISRSLTYGKDNSTFMDYIHMMGMAWHNIPQKYIQSLSYPLEMAVYSLMSKKKVIVIIVYQDGARCITYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KX41</accession>
    <name>A0A835KX41_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KX41"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="269" mass="30686" checksum="AA8E6C0D991019B0" modified="2021-09-29" version="1">MIKLLHKHQPKHFETDSVSENTIRQKLFAWIPQSKSSRNIYTPPGSTDSYDRNGELIRVEKTGNDMSYSDAKLDGTTSSMPDMSDDEDSDKIQDLQREVEELKLQLAAAHNEINNLSMENTELKQTIHTLNNTYQLVKGATKKLSSEIGTPRKNVRLPTPNKEHRSATHLETLRHSKKRPISNKVKTTLHFDKKSVETKSSQEHKEGSSTYKVERNKLCIISSNKTNKVLPIAQATFPNQQICHYITTNCGITTLIYLRPKGRNERSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXC2</accession>
    <name>A0A835KXC2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_014270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000942">
        <property type="protein sequence ID" value="KAF9404575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXC2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="5">
        <location>
            <begin position="470"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9404575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="547" mass="63248" checksum="9B035ACF4FEA5680" modified="2021-09-29" version="1">MLLDFPRCDFDLLTLNGAHTNEATIHRQPLHSGVQKIASTRGTSSPQHHPFLGLADRYTNEDQGNVYGFHFIYSGNFVAQAEVEQYGSTRVQIGINPETFEWKLSPKSNFETPEVVLNFSSKGFNQLSQTFHKLYQTYLIPEQWQQAERPILLNSWEGNYFDFTEDALIEQARLAKELGIELFVLDDGWFSQREDDTTSLGDWTVNQVKLPHGIEHFADRIHQEKMTFGLWFEPEMVSVKSHLFERYPEWSLQVPNYPQTQGRQQLVLNLSLPQVQDYLIQVLTNYLSTNKIDYIKWDMNRHLTEVGSFLLPNDQQKEVSHRYVLGLYRILAEVTEQFPHVLFENCSSGGGRFDPGMVAYMPQTWASDNTDALCRSKIQYGYSYLYPPVMMGAHVSDSPNHQVGRNTPLASRFLIAMSGNFGYELAIKNQSPQELEEIKEQIVFYKKHRTLIQFGQFYRLKELDKAYSSAWLFKNEKEALLVYSNGLAQPAQAVQYIKTKYLEESALYKDTSTGQVYSGSELNHAGILVPRIKGDFHCFYRHWTIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXQ1</accession>
    <name>A0A835KXQ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001016">
        <property type="protein sequence ID" value="KAF9404321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXQ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="372" mass="42600" checksum="1547770E80CD0182" modified="2021-09-29" version="1">MTTKKLKSPFRYDIVGSFLRPKALKEAREAFVKGTISKEVLTQVEDQAIISLIEKQKAIGLHAVTDGEFRRRWWHLDFIAGLNGITVYDFQTAAFGITTEAQGSYVSGPLSFPDNHPFLEHFRFTQKHAAPALAKQTIPGPNMIFLNSLILSKQYHQQPIYDSANHFKEDLIRTYQQAIQAFYNAGCRYLQLDDTSWGGLFDERFREMITANGFDPDQLLTDFQEITEKCLATKPDDLTVTFHFCKGNFQSHWLYNGSYDKIAKNLFSIEQFYGFFLEYDDERSGGFEPLKELDKQRIVLGLITTKNGKLEDPSVIVKRIKEASQFVPLEQICLSPQCGFASTHEGNHLTEDDQWKKIALVKEIAKQVWIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXQ8</accession>
    <name>A0A835KXQ8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000755">
        <property type="protein sequence ID" value="KAF9405349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="27011" checksum="4B82263960A323E1" modified="2021-09-29" version="1">MPYSNIGQNFNKSGKTGRASEEYGDKIKNGRTNKASSKSKKNSRRNEDIKNIMYRKIHHQKHTISNSNLESSKTIRITFPNEEMQKELDMAYEGAMDLLAIINEDGVDTSKVENEDIHFKVPKSKRLSWTKNGMDKELDLAYEGAMNLLENINESTVGKKQGESASCVTDHIPSQGGDEVKGRETQQKFAIPSVLGGPNKQLESHRNLVAPNPTDLIYQGVMEVTKNINKGDVSKSQGLQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYR9</accession>
    <name>A0A835KYR9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_013343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000627">
        <property type="protein sequence ID" value="KAF9406200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYR9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="247"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9406200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="38280" checksum="C3B5763BFC911BEC" modified="2021-09-29" version="1">MCSPHTLCVVLHSEPAPSAMTALHQFGAEMLRLSRGLEASAATKPQYRGTNISERGGMLTPGSLSVSSSSPSSMLQDRRRPSSTGEPNTPLHRPRSASDDESNEGLLAPAALTAKSRSSEDGLLLPPPCTCPYFGSESTPPRRTTEVIIVPGGDINGCNGYPRNGNMKEEQSTPFFRRSSRGAASMVTWDEAKRFRRGSSFGGARTTLSTPIRSIRAQRTIARSQQVTASPQRQTPRTHHSRNSSVISRNSSRHGRILRLEQKATKVLGVVFFTFVILWAPFFILNMVPAVCPDCEERISPWVYDFALWLGYASSMVNPIFYTIFNKIFRQAFKKVLMCGYWKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYZ2</accession>
    <name>A0A835KYZ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYZ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="962" mass="104200" checksum="7BDA8D096F370F51" modified="2021-09-29" version="1">MFDEPIQEHDYSMSSSASRGIVSYKYDAVLQDINLNDLRGPNTPLNVYSPKITSTQKPSPLALTPASIEPLFSVVTNDPNDPSDSLYNTPDTLAPTSCYKEIEDRTLTPEIGTSTQESFPDSHMDNGLTINTDSVSAISTPCNLISSPATFNDSDYSAVSTPKNTKPRKRKRLCNTGLEYTTSKGKTKAARSMKASCEKCRLQCYNKIGYEVRVDLFDKFWRTGDHAKQWEIIAKYVIQKSKKTATNVESESSRRSHTLHYHLPIKSDNGIRLQKVCKTMFLNTFDISKDFVYTAIRKIQEINDFTDVTDDRGRHKNHKHGQPKGPSQGQPKGPSQGQPKSRDASASETSRAPSAASIVRGGDFVSDSDTESNMSGSNCGSKRQSRKRAFLRRDSGDSPDQAAKPAKRPVTTQADLEEKIASKEQRTRTARAKAGYGASSVLYADHSVEEMERMALEDQQEILEVASKSSNLKGTFQKALKCRAASLLGIVKELAQRTTSDETRQLQAKVDRLQKEVSALHARVAELMARPEGTSEGPASMLAPSNLEDIIRKVVMEERAFTRACFAGIEDRLLPEKRLRPPLAADRAPERTPSAPGPSTAPAQHQPKGKGKGKGKKTTPAAPTAQTVPQDLPREDPLLPSTTPSNQPWTKVVPRKRKGKKKVAPKPPAAKPAAAVEKRKKLPLPPKSAAVVVTLTPEAAERGETYESVLRRARANVDPAQLGAGRVTCRKTQTGARIFEFSGAQGGTKAELFAAKLREAVADTAKIVRPVKCVALEVTDLDDTVTQEEVVAAVAAAGGCAVESIKSRAIRPGRGGMGTMRLECPIACAKAVLAKGRLPVGLSSGGVRALEDEPMRCFKCFGIGHTRALCPSSAERKELCFRGGKEGHRSATCKATAPHCVVCAANGRPADHVMTGRKCRPPTKKGKVQAPVRPATAAAVTETPGSPHSVDFLAVTPGQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ21</accession>
    <name>A0A835KZ21_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000321">
        <property type="protein sequence ID" value="KAF9409396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ21"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="166"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="38724" checksum="7AFE0BC465ABAE3B" modified="2021-09-29" version="1">MLRGSAHKERIARRHLTDLSDCVNLPDSYLLKNCGVNRIVFHNILRLLEPVVPKTQRSNGIPFPLKVLVTLSFLASGSHQKSVGKDFSINISQKSVSRVIKIVVEGLNMVLDNCIIFPSTVMQRDQIKEGFYRKYHFPETIGCIDGTYVEIVCPRDDEEAFYDRKDTKIIAICCRFGGSASCAYIWNKMNIRPFVESISRQGEMSWLIADNKYPQRAWLMTPILHTPQGTPDSQYNHFQGRTRTCIERCIAKLKGRWQCLHKRPLHYTPEQAAKIINACAVLHNLCTRAGLPDPQPFVDQEPMPVINEVTEMPEDNVNDLYIGIEVRRQLAERIYYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ55</accession>
    <name>A0A835KZ55_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Der</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000876">
        <property type="protein sequence ID" value="KAF9404818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ55"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01894">
        <property type="entry name" value="EngA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01895">
        <property type="entry name" value="EngA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000004">
        <property type="entry name" value="GTPase Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000040">
        <property type="entry name" value="GTPase Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000057">
        <property type="entry name" value="GTPase Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTPase_Der"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43834:SF6">
        <property type="entry name" value="GTPASE DER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="8">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="8">
        <location>
            <begin position="175"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9404818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="436" mass="49108" checksum="9A82BC6E01212150" modified="2021-09-29" version="1">MANPTIAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYTTGEWLGREFSIIDTGGIDLGDEPFMDQIKHQAEIAIEEADVIIFVASGREGVTDADELVAKILYRSKKPVILAVNKVDNPEMRNEIYEFYSLGLGDPFPVSGSHGLGLGDVLDEAVKHFSTEIEEDDEDTIKFSLIGRPNVGKSSLINAILGEERVIVSDIEGTTRDAIDTYFESEDGQKFLMIDTAGMRKRGKVYESTEKYSVMRAMRAIERSDIVLMVLNAEEGIREQDKKVAGYAHEAGRGIIIVVNKWDTVEKETNTMRDFEEEVRDEFQYLDYAPIIFVSALTKQRLNKLPDLIETVSMNQNLRIPSALLNDVVMDAIAINPTPTDKGKRLKVFYATQVAIKPPTFVIFVNEEELMHFSYARFLENQIRKAFTFEGTPIKIIPRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ63</accession>
    <name>A0A835KZ63_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000309">
        <property type="protein sequence ID" value="KAF9409569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ63"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="79" mass="8410" checksum="9C8D0880B1EDC61D" modified="2021-09-29" version="1" fragment="single">MKVKCVQYSTNLVISAETTRWRGVAHFPDCGCSHEAVARLEGLCRLSIASSAVLVSRRPEAGAGIEVLVAGAHGRGESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ92</accession>
    <name>A0A835KZ92_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000422">
        <property type="protein sequence ID" value="KAF9407928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ92"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="401" mass="45106" checksum="D9376CFCC086969A" modified="2021-09-29" version="1">MGDKHDSYICRRKSRVNGRHGLTFTTMAHHPLIYYAEVPRPLNRRQTCEQPRKEKNCFVKAFKWYTQERIPERFDCVPEMSSFAKWLDNKYVEYLCDSRQNQCYEPTPQATIKECVPCATTREPRTTKKFARIKRSRNQSCEFILQPKDLTRAVSDNCYQTPTSEVRSNATVVSSNVPGSFKCSGRSQSLSSIWRERSVLKPIDTIPHTVQEGLKTWEPKKPSESCVCQHDQIQQMPSNLQAAAVACQCPEELVIPVNVEIQCESATQERHGSCHCNVNTGNAPISSQCLCNSNECVNEVTPKLEPQEVNPVPKPIRWQSQSTVTVNAEECSCTVKEIPIVSKVTQCLACVTNDAVQTSDHAICFFGGPYDMAGLFCGKKLYEADDSADWELMAAGAEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0Q6</accession>
    <name>A0A835L0Q6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000455">
        <property type="protein sequence ID" value="KAF9407586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0Q6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="12142" checksum="892AF4C332C12B4B" modified="2021-09-29" version="1">MPTQARCDRVPPPHAKWDALDLRVLQEDDLPLDPRSWGRAEVGTWVSRRGGLPERFPMNGKALCLMSKDMFASRVPHNGHLLHQDFRRRLAKALALQELIEKIATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0R1</accession>
    <name>A0A835L0R1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_012427</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000454">
        <property type="protein sequence ID" value="KAF9407605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0R1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 13 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="153"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9407605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="36853" checksum="BBD3F366FBD13753" modified="2021-09-29" version="1">MAAERKARQELEDHRQKAKMAQESKRERRLADEDALRKIKQLEEQKYELQKQLSCARPNADPLHAFTRPFAGSPEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANSLHKLLREEKQLLQEQVLTRDQQIESMGAVARRLEEKERLLQATLSAVEKELLLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSALEAEAYKTKRLHEELAILRRKAERMKKMEQAGSSMDEGTTGGDPGVKRKDAVLTKCFHVFCWDCLRTRYETRQRKCPKCNAAFGANDYHRLYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1H8</accession>
    <name>A0A835L1H8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000226">
        <property type="protein sequence ID" value="KAF9411391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1H8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="163"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="34945" checksum="F1EC852A5878EC7A" modified="2021-09-29" version="1" fragment="single">IIFSLATEAVFRCDYKYSPVAKGWFKHYVIPATWGEARIRCTLQGAKLASPLNFDIETEMINIIRNFITSGTEIFTGLSANISRGNFYSIEGVPLAEIGSPWAVNEPNNVGNNENCITFNAYGEIADRSCDEPRPYICFRSGKVETEANECGTIDSEYQWDRRSNSCYKLHTVSRTFADAHFACSAEGGHLAIIKSDVEATVLKELYAKYPPEKIVGPYDKNYIMVGFHSWADSSDWRTIHGETLKEAGYSKFAPGEPNNASTGEFCGSISRSGLFNDLRCEIPTPFICEKKPDYPPVCSQSKNQYNFREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1L6</accession>
    <name>A0A835L1L6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1L6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38675" checksum="2B28E17FFF7B057D" modified="2021-09-29" version="1" fragment="single">MCKCLDEGCEPDISSFKTDVGSGIIDMDKKLLSNTPEDDDAQLNTFKKRRAGHKGKVTIFKNYIESLNSKKKIALTELEILQLKNRLEVYKTLEHDFDVNQTLIEDIVGVSDEQLKEREQFDSEYQNQLALAMQLMRDSESTGITDGSVQTPNAGGTKAFIKLPTIDLPHFSDRADLLQTLEEKHKQNHVDIKSNKPAQNQTSTSRSPSCPLCKAQHYLFSCPDFKQMTVEKRIEKVSKMNVCSNCLYPGHEKKTCRGGTCKYCSLKHNTLLHIEKPKSSSITCTSTQQTSVLLSTTLVDVLGSDDQLSRFWELDSLSDSQNTDPCDADACEVIFKQTTTRKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1M4</accession>
    <name>A0A835L1M4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1M4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="103" mass="11764" checksum="7204E1F79A7B2D26" modified="2021-09-29" version="1">MGIMFFVVLGWAAKNLIYLTLNCIQSEKFYIMVEKTEETCLQLMKNPNCSKNQKRLCRVVLQANRSFSKISACGLFYVDATLPILFTEVLTGNIIVLLQFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Q6</accession>
    <name>A0A835L1Q6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000216">
        <property type="protein sequence ID" value="KAF9411711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Q6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF14">
        <property type="entry name" value="GEO07393P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13225" checksum="EF2F9A86B9DD719F" modified="2021-09-29" version="1" fragment="single">NRSSASAAACGMECGVAAGGYAAPPAHPALSPTERSPAKSGLHVNFSDKGEVKERREKFLTAKYGSHQMALIRKRLAVEMWLYDELQKLYETPTLLADAKKPQKDVHKFINDLLERAKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L338</accession>
    <name>A0A835L338_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L338"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF54">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="391" mass="44795" checksum="B76109318E38E299" modified="2021-09-29" version="1">MSVVKQTLCKVLDKVVHKLQMPNANISIKNLTSDGGYTSALFSVTVSAPERNNLNLFAKVANVNVKLRQAMNTELLYTTEQIVYNELVGVYDKIQDKYRISPEHRFVFPKFYGGEDTVGHETVVMEDMTASGYAPLNRFESIDWEHAAVAVEDLARLHALSFAYQKEDPSNFAKDTERFRFVKSKMDFSNLKDTWAKIGESAMETVKDEHKDKLKKLLANGSTQDVFYKFRAPLSTVVLCHGDYRVSNLLFRRVDGRLQQIVVDYQTMHSGCPPTDLLYLEFLGTDQEFRNKHHKQLYDYYFSELSKALDRFEIDVNKVYPKATFEKEVREMYSPALTVAMVVLPLVLVDVDRVPHLSKIEGIGDFALKPSHHFSTRFRDLVSDCVEWGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3B6</accession>
    <name>A0A835L3B6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3B6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="455" mass="55143" checksum="689D8B44336CDD38" modified="2021-09-29" version="1" fragment="single">ERQRLEMKTTVDVEEMKKLTDVVDYDLVHLQKREKLKELLQSEEEALIQELVTKQEMEECGYCKEKEKKHKGYLEEIEKEKIRECQKALEREKIAKGTKVDVKCLKQQQLMQIEEKRCIERQEQHVDMMWHQVLMDDCNRKEHLERLAAQKRQQETIERRRCYDEQIASANKKRQELIRQEREKENRKFEKIKKKMEQDHYEAIKKKKEQQETNRKNFIEGHEQKLMRVRNEKMRAREIDNDTIRVALEELRKERERNMIQMKNLQIEKQICIKNYNCARQMASAMEQEAEMIADEWQRQAQEKADEHMRQVEQEQRLCKEKAAEEYRRHVQARNRALEEAKHERSQRMERVTRTALTELQQKIDSANQELRRQAEYRNSLSCQIRENEKHLESELINIEKKDRPYTKKGAMFKDVMATRYASSPVRTSTNPVHPFRRLLETTDKKKPLHLPSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3X1</accession>
    <name>A0A835L3X1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3X1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="15542" checksum="074422A13DA70CEA" modified="2021-09-29" version="1">MVIRAGIVGNPVPEPPHFANTSGLWWFIGDRDRRSEGRFYADERFWQTSSLYFTMEDGFVKAESTNLPMVNTLMVAQYFASNPDFCSAELRNVKTAMSGRESYGDDALGYVQLKRVQNTCELIRIRLTEPIILYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L494</accession>
    <name>A0A835L494_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L494"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="527" mass="60389" checksum="179E42E29BB4C3C6" modified="2021-09-29" version="1">MAVQRPGKMLAQKGRNVAKITSTKRWNFNHVFDRECNRTSATTRRDFPSQEIPECVGEAYLKALTPVNITNAFNKCGVFPFNREIFSELEFLPSNVTDRPQPILDETTPTNIDDDDATSCDSSLADKIKQNWMPITTWMVIERLHHSYLSASRITPDSSQPYTNFVSPKDFRPIIKGPQNTRKSRKKAGKSMIATDTPEKKCYDGKKNKETKKSKKEAEKMLGRITYSKATTTFTTFFKRKRFSFPLNKLCKRRKRNLTPLESLDNDQEEFQPSGSSSGGENLIASDSDEDDLVLRDDFPPLKHIQLAIVDVMYNRNKDIEEDVGAPQMILEQLDELGFYEDLPLSELSLRIRSGEFSNETHNGENNNDEDDGAEFSNESHLASLPPQSFSYYQFIAKKLIHPKKPDMAGVNTVDIKYICHFLKLKIITIDVKLLTYTPIKSEARKLIFNMINKFDVTNKDNEKIFNEKEQCLVTILEAIGTENIDVNKIEESVKNLKVIHNSERITASKYMEEINNRCKSCYNKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L501</accession>
    <name>A0A835L501_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L501"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="519" mass="62571" checksum="0320FE67CA739D6D" modified="2021-09-29" version="1">MLSESKKSRKHYGLSYHTACKDYIKTFTCMTACKSIGYQIFRLDFTCKCKCHELKTTTVLPFFKWRTNGTTRKWGRTSSPSLYNIAGTLSPRTYPDYEDIINNFTSPAINITQSESLNITTSSGENTTVSALNINETSLSTLEMTSWAEFSEWLDINGTQSTLILRYGHQQTHKCNDFEKAFNCIQTCLYRGFQIARSNEKCQCFCIKDEKKAKRQFNPINTRRRQFNPINTRRRQFSPINTRRRQFNPINTRKRQFNPINTRRRQFNPINTRRRQFNPINTRKRQFNPINTRRRQFNPINTRRRQFNPINTRKRQFNPINTRRRQFNPINTRRRQFNPINTRKRQFNPINTRRRQFNPINTRRRQFNPINTRKRQFNPINTRKRQFNPINTRRRQFNPINTRKRQFNPINTRKRQFNPINTRKRQFNSIITRRRQFNPINTRRRHTELNRTPNTNSGQSKNATYVTQEYNDDNNNIIHTEDKLNVKFDSYIRSYEIQMLYERNNLGLVIKMRVISGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5N3</accession>
    <name>A0A835L5N3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5N3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052123">
        <property type="entry name" value="Non-rcpt_Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="74"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="303"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="432" mass="49979" checksum="E239009C6C0852C9" modified="2021-09-29" version="1" fragment="single">QHDKYDVGSGEQFDDLVGLIEHFRLYPMIETSGDVLRLLQPVSGTRLRAHDIDRKVQEMQEIEDYQKLDNKCGFDGEFQSLKMLEDRHIFTNFEGTRPENALKNRYRNILPYDQTRVVLRRRDNRPESDYINASYVRSSRLSDSSSSVQSSNESLDSVQSLILNSESKKAPPLVSKSLSDEALREVKKCLKLDKINGNLCRDVTVKDKTYIAAQGCLSNTKDDFWRMIWQEDVRKKCERYWPLSGHEERFDGLTVKSMSETHYEEYLLREFDVSNDKNCRTVFQYQFTAWPDHGTPGDPDGVLSFIDDINRRMIKNSQEADAPDQNILCVHCSAGVGRTGTFIVLDMLIDRIKTSGFNCDIDVHSTVKLVRAQRNGMVQNKMQYRFIYLALQEYIDRRNIKLRKKMRINVNILCGAPDRLTSSTQLVEIPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Y7</accession>
    <name>A0A835L5Y7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5Y7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="38968" checksum="2B22CE2582993408" modified="2021-09-29" version="1">MLLLLRVTRASNDVSSFQLLARLSFPTVETKPYNMPSSKEIDPRHSYADEKFEKLQDYYNYMNGRMKEPHNPSERREIMDIGSKKLYSFIDSHIKDMKRLLFATDMALMSMVLLKLNKKMDTSETKIKSTQAKIPFGLYTSPEFKCLDTSYYIVSAHNQEDAQMILSSERKPHCYTFRGAFAFSGFYHRHSETTYIGPHAEQFQAKDPSQGLYCHSDDNWSDAQCIYKINPREEFPESVEYEPKVSYYCGPYRYFIPATTDVRCIFSIFAMNFVFRFGYDGVTYKSSDLSFMYQNGQVFYTDEPWAGMSCWNWACKWRHNQNQRSNEFFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L615</accession>
    <name>A0A835L615_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L615"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032846079" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17181" checksum="925E7F82F8F0C0BA" modified="2021-09-29" version="1">MKILFLIAIVISVSHGHRTRKEDKLLLSPVELIDLVREEQHKNKAVQVKQTSTTVGHSPKLNKQMLEIDDSDYDPVSCEDDKTMKKRKIWSRWSKWGDCSVTCGAGTITRYRLCVAGRCAPGEREEQRRPCARAPCHATLYNVTDDLAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6N1</accession>
    <name>A0A835L6N1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6N1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="265" mass="29114" checksum="4DA0373FFB3D96C0" modified="2021-09-29" version="1" fragment="single">MNFATFAPVGTAGTHLVTTSGQLPVQKLQQNVANNGAAMQQVCVMGDGGVQYMRALDNSGTLQATPQLITVPVALPGVKPGDPQPMVQIQVLSPNILQMEPKYRMQIPIQGIQQGHQVLALPQEMQLVQPTQEKDHISQNMPQVFITPNQQIIINEAGKTLNNNTMSDNHNPNVIVVKEECDDDESSQGTEVGETIQWSIDPNHQQQIMKYLRSIPQQQAQGLPESLQQFLQLNPSDIKQGESIEIEMKNPNTKTEEPVAEAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L782</accession>
    <name>A0A835L782_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L782"/>
    <dbReference type="OrthoDB" id="7400720at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033066640" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="11073" checksum="2030ABABD38B5C4A" modified="2021-09-29" version="1">MAHSPTIILLLSVFLNIILVNAETNDKKTVEGMLLKVLWTKVYRGHDPETKEQIIRHLKKMGDYEQLINLLTKVNKKKVEKLLNLLAEIMIIYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7D0</accession>
    <name>A0A835L7D0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7D0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033093983" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="84"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="414" mass="47749" checksum="B1C91A87C74BF590" modified="2021-09-29" version="1">MNLYFCFYFVIISIYHIVVSQETNLLDSEIIEDKVVFFPSQEAQYDILQQEYENGLYTNDYTPLNDENMEIGALNDIINLHNESSIELQPAIFKWANGIVSYYVDPRSYDNKIMKRIRTAMNMIERVSCVVFKPMAVKAPEFSSYMWLSIENPTRIRRCIHRVLHDKSGKATMIIGYECMQQRDILHSLMHVLGFHDEVTHPHRDNYVRIVWPNIQPQYRSLFSKGFHSRSNDLVEYDTTSIMHFHDRAYTNNGAPTIVPLVSGLKIRELESSLLSQLDVMKLKLAFGNDCNKRNVRKLYETCHAAIGEDKEDNNNANYQDSKDFEDNQYATDHRAIPEVSDGQGVEDLSDGKESFEDLEFRDNIRSQNRQNGTVGQGGHDRAEKAVNPSPSPGIKQHFETLKNTTSKNVPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7H3</accession>
    <name>A0A835L7H3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_002947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7H3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="616" mass="68638" checksum="4A0DBB8BE53532F2" modified="2021-09-29" version="1">MSYNQGCMTPTTGAAHSTFLSAAQFVMAAQCLIQTKDWPEDAELHESEEFDFIIVGAGTAGSVLANRLTEIEEWNVLLLEAGGDPPIESDIPGLTESLYGSKFDWKYTTVNNGLTSQANKDGNIKWPRGKMLGGSSSINVMAHVKGHPRDYQSWYDEGNEEWHPDIVKQYEQKAESLQDPILLKNPAIQNEYGHDGPLFINTYNVTNTTLLDNMLSAFDEIGIKPVEDLNTVKNVGAGRFRVTATDGKRISSATAYLNPVRSRKNLKVAKNSHVTKILFDGQTATGIEMDRNGHKYTLKAKLEVIVSAGTINTPQILMLSGIGPKKHLEEKNISIVLDSPMVGQNLHDHTNIPTLIFADEPEVMDKATKDLESVRYLYDRKGYLAYHSYQDLTAFYSADPNSTYPDFQALLLFHYKHDGSIKSFASEYVKSVENSVLKLGENRAMFQVRISFLRPHSRGNISLNSDNPYDYPLIYYNNFSDERDLDATVTGIKMFLKIVDTKFFKSIGATMGRLELPACDGYEFNSDEYLRCIVVNMASTIYHPVSTAKMGRDISSSVVNSRLKVHGIKKLRIVDASVMPSITSGNINAPTVMVAERAADLIKEDYNKLDNKPNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8D0</accession>
    <name>A0A835L8D0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8D0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF9">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="383" mass="43004" checksum="E470B0001E560E1F" modified="2021-09-29" version="1">MMQESHFEDTNLSMNTRILKIHHHIDSLTKYLTPLLPIANCHMVEFITQNHWDNLLPVPLREVLNGLQFNEALKQFWTAAESKETKDTGILANWIHTARSHCVSVNNDYCLSAEQLRERIKTWGGEIKPEIRVKEFMTSKKSYEVQTMSALVASLQAARGAQCCVEAGGGRGQLPVALCLAYSVPSLTIDCDAQAVAAAPNRIRIIQKQWHAIAKRIQNGIEERIDEGINKNLHRFATAYITEHTDIAAIVKDKFPELAGQDIKLLLTGLHTCGNLGPDSLRIFVQQPSTAAVFNVPCCYHLLTEAVDGQLFDVFQRDYGGEDTKQGFPMSEYLKGYNLGRNARMLAAQSIDRVVNDRQLPSISLLYRALLQVISLRNCHFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L972</accession>
    <name>A0A835L972_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_008929</name>
        <name evidence="2" type="ORF">HW555_000169</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000188">
        <property type="protein sequence ID" value="KAH9642519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L972"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032740613" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9642519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13722" checksum="B171C954FF6B00AC" modified="2021-09-29" version="1">MKVALLTLCFALGVLAQDTYENANDNFDISEVLNNERLLNSYAKCLLNKGPCTPEVKQVKEKLPEALETRCAKCTDKQKQMGKALAQEVKKNHPDIWQQLVAMYDPEGKYQQAWKDFLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA47</accession>
    <name>A0A835LA47_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA47"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="971" mass="108648" checksum="101B054FEC0679C7" modified="2021-09-29" version="1">MDNSAIQTLEAAAQMLMAPPQMVTSEQRHQAESVFLEFRSTKNPYQLCREILEKSTSDYVLFEAAGLLKAALIREWTLLSDSDVCSLREYLLNYLLRKEAPPFLREKLLQTIAIIIKRGSIDDGGRERKNLIAELEKIILSSPISQQKLACSLILAIMQEFAITVKSADVGLIWEVHFRLKKSFEALDLKRIFRFTVGVLEQIVRSGHRPEGEQALLTKQLLTIVETVLCWSHVSPLLSKRLIGAFEAIYESDTAPALRLSLSWRDTIMQPELLALFFEIHMYVRSNPDLASPSLTCLVQLASLSGVVVSASNLKQQYLENYVNSFLNMMAYIQPVEREMLGISDIYRRLIQFFAPTMIAATPPAFLQNLTNLTCHCIRGSVIEEGVNDDTVWRESLNKFLHSWSSLVHESDGYSNETLMNPCIEVFNTYLQSRLAPPDGTRPPDTEEDIKDELEEDERKLHSNVLMTIGAIARKAPAHCCHVLFTLLQDRSKRLESQLQLMHMGKLPISGGGHLVTLFEDLHWILMITGHFLAVDCTEGETVMIPSEIIHFSLRENANIDASLRYLVGETTNTENVDSVLKLIGEIMRINAWECAALEAGLGSVFSPELSATISWLLKIWANSYLMPQAQNPLATCEEFLALLQWEAGACNLPGELRKELHRAFAIAATYAEGDVRNRLLSSTVSLQEKLMNLINMESDTEPVRNMLADTLDCFIGVTDGVLEVGTMDEQFMMLIGALDKIPGIIFRYHNYPGVVLPALNLLAKSAKRMLHSVQPQNVNKFLEICNTTFEVYMRWNSGKISSIPQDAEEEAYELTNLPIDDFNMVVTALRVGLTAVSCDVSTLCCDTIVGLSNKVRTLGDDNPYALSLLTLAELLLMLIIKVEIPPDSIPAAGAAIYSLTCVKPALLEGLARQLIEAYAVNDPTNVPRLEEAFGVLTNGVLFDGLRTHKLRFQDNFDKFLASVHGFLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB97</accession>
    <name>A0A835LB97_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB97"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="193" mass="23047" checksum="4C5D440DA31F2E4D" modified="2021-09-29" version="1">MNRTRFGIGCCEESNGSMQKCITCMAFATVMPGLLPGNIVNATLTVIVFRRKLHRQEITKIYAFAFVLRERKRKRRNEDQVLRELRLDPSISQRQISRNLGIPRSTVQRVINRNKLHAVQRVQALLPSDYEPRVRFCREMLKYNREDLQFFNKVLWTVFFSYFRNKMGKHKDVDKELRRLRRKLQKLEEKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBP3</accession>
    <name>A0A835LBP3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="491" mass="56785" checksum="DF3658F6A8AD6C74" modified="2021-09-29" version="1">MEQDVETGYRALCSTCLSSDRDLFDLNNTAQDIFRLLMYDFAGDRFSEPMPEMEHLVCWECLALLKRFHKFKWQVHSAQEHLRVLALSRTQESMDHTYMSQSLSCLEMETKTEYDKIFFDFSTGDEGYIIQTQPQNVKNEHFDVSHVQDTNILDIDEHILEVPEIVLENPVTGVMSHIVVGPDSLDLDSGTSHGVMSHLTIEEEAKKKVQYASSVYKCELCIIGFYTQQQVEDHFVSAHRAKPRQVACKICYLYVDENKIASHTDSHYLKYRCKLCSHEETSTKLIQQHVNTHMSKQTNLSTIKIGDLKNKGKKKKDKDTKEQKDPPKPGDLRKLLSKTSIEGYQCLECDMFFKNSRARKNHVARFHREGLQCDHCKKRFVNRTTLATHLKLHEGPLPRSECPICHKMVRVIQLKYHIQRHQNKSRYECTECNKTFSHLATYQAHLKYSRAHASEQIPLSDVQEGISNEASDAGSLQLPTSRQNYTQVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBU3</accession>
    <name>A0A835LBU3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="130" mass="13736" checksum="965E831F8F386A4A" modified="2021-09-29" version="1" fragment="single">SQRKVPSAPASPPRRHGLRSCSNLCRRSDGSDREVRSIRHDVVWNCAGSGGQTKQRQSVTRETQARAHTPEAGGVAFGGGIFRLRGSSSSESDVRSTITSAERGARASPTAARLPAPTPLSTGITSVEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC10</accession>
    <name>A0A835LC10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_002558</name>
        <name evidence="7" type="ORF">HF086_008832</name>
        <name evidence="6" type="ORF">HW555_000453</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000140">
        <property type="protein sequence ID" value="KAH9643345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000135">
        <property type="protein sequence ID" value="KAH9643439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9643345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9643439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="36005" checksum="4AC9E34FCAAF741D" modified="2021-09-29" version="1">MEIQNCGSCGDNVSEGVQCTVCNQYLHFQCSGVTEAGYRRLGDRKFTWRCFKCKQSNTPQPPSSPRPENESAILLEIRALSAKMAPLDNLKDEFSALRSEFAELKSSFHNQYIAMIDDLNNKINGMESRIAQAEKVQEQVASIRVRLEKLEEDSDNKDQWSRMSNVEVKGIEQTKNENLIDIIQKVGTKINYPIHKSQINFVTRVPTKDPENIKPIIVCFSNRYVKEDFIAAARYEFKTTPLTADQLQLKGKHRIYINDHLTTKNKNLLSKTKKAAIEANFRYVWVKHAKIHIRKTDTSPVIIIKSEKDLVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDS4</accession>
    <name>A0A835LDS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDS4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="52680" checksum="9987BCA6D9F53D0D" modified="2021-09-29" version="1">MEKGRRAQYLVAAAVSLAAMVAGATQAWSTPVIPKFHSNETNIIITDDQISWVAALASPGYMAGSMATRIVSDKFGRRTAVLGSGLPILIGTTVILTTASARCLYVTRYLWGFGTGMIGTVSAMYLAEIADKEIRGKLTASIRFMLSFGSFIIMSIGPFISFNALSYIFLALPICYLIACSFIPETPYFYLKEGKVNAARASLKRLSGDRNEKAVEEKLLAMKLDVKKEMHRSGSAKEMFTGKRYRKALIIASGLKVTQIMAGPIAIQQYFGRIVQESKTNVNISIVLITFGAVKFIVGIISSAIVDKVGRRPLLIYSYLGSGIALSVVGAYFLIQPTSSPYYTYIPFVGIILSSVVSILGYEPMAFVVSAEIFPLNVKSIAMTFLNILGGLLNFLCVKGYQPMKNIAGLTGVFWFYATFAFIGGVFSFFMVPETNGKSLREIQIELQGDLYDETYEKPQNVVVDDGTEDTELQKLKQDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LES0</accession>
    <name>A0A835LES0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LES0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="46137" checksum="36BBE91B6D3794EA" modified="2021-09-29" version="1">MENVVFEGHYGGGDRIRVGRILVGAPEDQLYSAYEYNVTRPGAVYRCEPGYRNYAAEGNVRTLDRCSPMQFDKNPKFNVSFRNHEQMTVPCPYCDVCRGAHARDSYRARAPDLYDIRQLLRKVTLNAVEMMVRQPLSCYMVQDLRSPEAAYNFSEITEFKSDNLRIPREYQGRCKMASNNFRARKLVHMVVNTDVCHDNSVRNTELSTSTLTIEIEPEDTKKSEDEIFTDRQDIASSQDVVNADFSLNLSSAALGDIRVSDYSFSKDESFGLLCNETLTHSLMGSPVADFGTEDEPTTSQGLQEIENQRSNESCPDVDNAPTTSNNQILVTDSVMQNEDNEAANRLVCDALKGTTKKGTPRIRKLYTESTNTRKEAKKQKKIEKFCVKPACTTSCKKNVERNFQSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LF30</accession>
    <name>A0A835LF30_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LF30"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13944" checksum="900189F40585F619" modified="2021-09-29" version="1">MKHEEIRELVLQDQTREFLSNELIGSSISIPRPFWDELVSCHVVFPNGIVYEAFPEDRIPPGPISFMQAVQPFVGCSIGFLNADVSFSGTYELMSLLRHSADNSLSLTRQRFHVTLIPHDPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LF63</accession>
    <name>A0A835LF63_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LF63"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11428">
        <property type="entry name" value="bHLH_TS_NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="47434" checksum="A5E4B29710CDB814" modified="2021-09-29" version="1">MFSTNFEDYCDFNDSICSNDSGIDRSYTDSFINSTNSTPIKHETSDLGISLTPTKDVRRKLFNDDYDLFQDPTDDVKVFEENIQNMNTSTPKKEKKPKDPNKPKRKYANGKNRISRCKSPTQLMKIKRNRRMKANDRERNRMHMLNEALDRLRCVLPTFPEDTKLTKIETLRFAHNYIFALSQTLESLDNINSGQAPAEDYNLNYEKLQNYSMAGEKIAKDAFRDIFLVPNKPEGCNDGSYRNFQGFSRPFPNGSNFMQTSEGVLINVGNVTVSVNNKGGNCITSTTGTGFFTHPSSFGEDMNQQAYQYERYGAPSFNEGYEANNMSGEYFNQKNYEIFKNAFDTAAKSRKIEKTEDYNYGRYNNSMYGYTDTNCFTGNTNEYLQSSYYYNDQRCYRNFYNRAPSVVNAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFD9</accession>
    <name>A0A835LFD9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFD9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF5">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 8, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="273" mass="30875" checksum="EA306409F40CEBE3" modified="2021-09-29" version="1">MKLCRQDSTNNRPRDQSTVSESSRRFRTEFLEDWPQTPGAPYFDPSTPENVTGLVGHPVTLLCKVKNLQNRTVSWVRHRDIHLLTVGRYTYTSDQRFEAQHKPRSEEWALRIRSPQRRDSGQYECQISTTPPIGHAVHLNIVEPETEIMGGPDLFIYAGSTINLTCIVRHTPEPPNTINWTHRGKTINFDSTRGGISLVTEKGIHSSSRLLVQSARTTDAGTYQCAPDNAQSATARVHVLTGEFWKLLLITSNIPRRLETCVPLPSTLTLRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFY3</accession>
    <name>A0A835LFY3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ska2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9423979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042091">
        <property type="entry name" value="Ska2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16740">
        <property type="entry name" value="SKA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ska2 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="12663" checksum="C7A665200738A538" modified="2021-09-29" version="1">MTDKEISVEELEETVKQTDEQLDLMEWKMDNVEKELVEPINTQDMCIMHLLKSVSEVRSDYQQLRRELVEVQALQRELSSRLRTQLRLVHGKFARLRQRLAAASPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G029</accession>
    <name>A0A835G029_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000905">
        <property type="protein sequence ID" value="KAF9404694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G029"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12124" checksum="4C9BB8EA01232B56" modified="2021-09-29" version="1">MLLHGEAAVWWRGIRTEVSSWSEAVKRLRSMYGTPCPAHKLYRKIFANEQSEELADSFIVRIRGMIAKFPYVLPEEAKIDIIYGLLHKRIRKRLPGTRLTVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G190</accession>
    <name>A0A835G190_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_013671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000695">
        <property type="protein sequence ID" value="KAF9405707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G190"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9405707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="105107" checksum="026CAC054893DBE7" modified="2021-09-29" version="1">MYKNSWIRTVIIKMGVIVKNATQSVSISLTALQIVGFWAPENLTETQRSMYKWFGVFSFMFMLGTYIFIQVVDLFMIWGDIPLMTGTAFLLFTNMAQAAKIVNITVRKQRIQNIVNDSNKVLSEVQTLAEKEIVKSCNREMIVLQVLYFSLTLVTGLGWATSAEKHQLPLRAWYPYDTTKSPAYELTYVHQVGALLIAAFLNVGKDTLVAALTAQCRCRLRLLGLSLRSLDKGLDIEDKYMLTAEQEKIVSCRLRSCVLQHQETLKAAKELQECFSEPTFAQLTVSLIIICVTAFQLSMAQPDNMVRLLSMGTYLLNMTFQVFIYCYQGNQLSEESFEIAGAAYECHWYKFSLRLRRALLIIMVRTRRALRLTAGGFTTLSLTSFMAIIKASYSLFTLLQQSSFTLDTCSLAYFTLISQCYQHLPNKIYHHDNHYVNDEQTEIHQTPIMGLIVNNANNSLRVCLTVLKVVGFLTPPQTGVYSFILSVYCFASFMFLVGGIIIAQTGAMFQIWGDLALMTSASFLLFTNLAFALKIINVVARRRQIQDIIDDADEVLVAEDREEGKEIIKSCNRETTRFLCMEVLLSLITVLGWAASAEKDQLPLRAWYPYDASKSPAYELTYFNQSSSVTFASMVNTCLDVLVASMIAVCRCRLGLVGLSLRRLCEGIPVIGKDLLTSDEEKIVQSRLRQCVIKHEAALKSTRLIQKCFSYPILAQFTVSAVIICVTAYQLAMRPQPSIPTQVWYHSRVLLGGRWHLFFPPVWLLFLTAYLILAPQISFARRQLRYSFSVWHPLLVPIGSTRRCSLGCMSVPKCGPGLQLGGRRIFPSSTEKRALKLAISLRIRRVNSVFCDGDCGCGRVGSARPTSCLRCSRRKFTISALSSSPLPVRHLCCELFVLGPQMEAVASLSPAAAAKALRDFAHLSDCCNRVNQPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1U8</accession>
    <name>A0A835G1U8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000784">
        <property type="protein sequence ID" value="KAF9405208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="26424" checksum="5AC7E4D92845B12E" modified="2021-09-29" version="1" fragment="single">IEKTQCKQDFYYKKYQEDKNAQDAPDRIINLMRSYYEENHARIAALNPLRFMYRKMVETVQRPFKYKSDSFFVILKRVELTQKLYFEIYHLARMMHETPRKWKSVPEFRETEQLPMSKNKKGGSATLLSDDEAQGPSAEDLAKINEFKEAIGAAEKKRQLEKKRKRKLNKKIRELILQKAEKYPNMKFNYSEWFKHLERKYNEKWPIDYGWEIEDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2K0</accession>
    <name>A0A835G2K0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000546">
        <property type="protein sequence ID" value="KAF9406809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2K0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="108"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="441" mass="49490" checksum="2507DF176419A2E1" modified="2021-09-29" version="1">MKKHRSTYETIIPCSVSDAAVENNLEAPSTSNKALPSTSTSTESNNPTQQYPKAPVHNGPCGSTAGHRHCVQGVMVYDGGQWSIVARNRGVVGFLGTLQRNRGVAWPVFIDLYQSEPAIWDPNNALHKDKNKVNDAWNRIADSLQIPVSELKKKKETLMSAFRMHLKKKQDSIRSGMGEEEIYKPIWVFYDAMEAFLKGKYTCKSITSTDEQRSNTETKDMNIKIPVQRRRSVKPPELEKADKEMSKAFNTLNQAILNKDQQNKKEDDCDLYGRLLANKLRKYSDNERQDIMYDIDGLLLKRRRNTSPQYVSSPSQIIISKRPSSSATSYSCPSPSSPWINHPSSLTSSNHSYIITSPIQSPSPIPPAQTPSPLPPTELPNALYTQEVVHQSPNRIHTPVSTIHIPEGSMQIISDELYSQTQSQSQNVLADAYARALNNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2N7</accession>
    <name>A0A835G2N7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute-binding protein family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_014237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000919">
        <property type="protein sequence ID" value="KAF9404649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2N7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.76.10:FF:000001">
        <property type="entry name" value="Oligopeptide ABC transporter substrate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.76.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF10">
        <property type="entry name" value="PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032695673" description="Solute-binding protein family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 5" evidence="6">
        <location>
            <begin position="93"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9404649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="24503" checksum="C513CEF37123CAE0" modified="2021-09-29" version="1">MKKTTAIKLTSIVMLSTLVLAACGGGGKTNSTDSGTSGNKASGEQLFRVVVQQEMPSADLSLATNTISFSALNNIYEGLYRLDEKSRPLAAGAAELAEVSEDGLTYKFKLREDAKWSNGDPVVAGDYVYGWQRTADPKTAAEYAYLYELVKNGADVTAGKKGLDELGIKANGDYELEVTLERQTPYFDYLLAFPSFFPQNKKAVEEHGADYATSSETSVYAAHYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2R9</accession>
    <name>A0A835G2R9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000519">
        <property type="protein sequence ID" value="KAF9407006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2R9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14389" checksum="F87A6592EE232D21" modified="2021-09-29" version="1" fragment="single">FKFSINEYFSFPANTAQYAHFVFNTLDQDRSGLLSFEEFVTGLSILSRGTLEEKLRWTFSLYDINGDGCITKEEMTEIVTAIYDLMGKIKMDLNRDGVLTLDEFLDCCLRDEDISRSMGVFDSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G352</accession>
    <name>A0A835G352_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immunoglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000788">
        <property type="protein sequence ID" value="KAF9405195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G352"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="2">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="2">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="2">
        <location>
            <begin position="215"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="2">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="595" mass="67023" checksum="6773DEB437DEA1C2" modified="2021-09-29" version="1">MIGDWTLISRATRTSGTTITHVERRRTFSIHVEETLATGNPITITEGSDLYLRLPETTDLYKTCKLYGPTGEELSEKQYLIDEIHRESCGYIIEKVNLSQSGTWTIVYGKSIIYRSNIQVNVLEHVQLAVQDQQWTVGQSVNMTMGPADAVYCNLYNSRRDTVFDDFGPCRVVIDRVTSDLRGQWLIHVGVPGSIGVQYQTFNVDVLSPDWRPFVTTEVVEAENTVTLSCSVSSNYVVKACKFASPEGHILLANQGVGQGVYDGASRYETDTNGLRCKITLTNPELRTRGIWRCAVHTKDNTGYGFLTYYRGYKPEHNSNSDRYDVTVPYLRSQFRFYSVTEGENSILSCIISAPIRYCYFRSPNGTVFNVGPSLSSDTYEYVGNGFDSGECGVKFHQLGIDHTGPWSCSVGMTNFEERTDTFEVGVSEPIRVFHTWRSGILEIGAIAGDWLPLDYCRFVRNDGLGFNSINPPPDYYTYQWSVYEGKCILAITDPTRWDLQPWTVFVKVTGETAERSDTTGVLQPPVEPNSKASKMLFWMLGVTMGFLFIIAAVSLIPPKNRKWTYNQATSIRNSFRRSPIPTQEAVQNDLPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3S0</accession>
    <name>A0A835G3S0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000561">
        <property type="protein sequence ID" value="KAF9406680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3S0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="25120" checksum="18673B70F62A967D" modified="2021-09-29" version="1">MTEKWGITPEKVAAVVTDNGANIVKAVTIAFGKQKHLWCFAHTLNLVAQKPFEEKAGIESAKQLLNTVKDITRYCKQNVNVADALRKAQNDIAVPLKLIQSVCTRWNSIYYQLVRFVKLSELLAPILLNYPKAPPMLTASQLDGIKDLINILKPMEAVTKEVSVEKFVTSSKIIPIVSCLLKTYSTMKTETDVGAATKNLILEELKKRFGTVEQVHVLAITTLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G500</accession>
    <name>A0A835G500_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000687">
        <property type="protein sequence ID" value="KAF9405756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G500"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="66" mass="7624" checksum="A28AC854F52A5969" modified="2021-09-29" version="1">MTFGRIHPRSMPGLWLRRTRRPGILYEERTQFLQARDPVLISIGCFEEDIAIPSPTASHAKMMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5W5</accession>
    <name>A0A835G5W5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_012439</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000455">
        <property type="protein sequence ID" value="KAF9407591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5W5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9407591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="702" mass="76084" checksum="2851FA94628F13D7" modified="2021-09-29" version="1">MTCMSCVRSIEGSVRELPGIAYVKVELSENAGYFRYEPRTITEEAIRSHIEDMGFEVPNDTTEHETRNLLPKEIPTDLLIDMSGTGEMDEQEVLLSVVGMTCQSCVNTIEGALRELSGVRSVSVRLSEGTARIRYVRGTTTARQLADTVYALGFSVTVLAVDGDQYTGQFYTMLSTFTPPPISKTPIPTKAVTNYIAKQKRGRIWGWSETTFSSQEQNSKGETSRCTLEVRGMTCASCVAAIEKHVQKLYGVHSILVALLAAKAEVKYSPAKISAADIANCITELGFPSSVISDCDGSGQKDLHVAIKGMTCASCVNKIEKSVLKLTGVVSCTVALTTCKGKIKYNAEQIGPRTICEAINNLGFDASVVTPHNRGTTNYLEHKEEIKKWRNAFLISLLFGGPCMIAMAYFMATMSHGHSAKDMCCVVPGLSLDNLIMFLLSTPVQFIGGWHFYKQAYKALRHGTSNMDVLISMTTTISYVYSLAVVIAAMAMQQDTSPVTFFDTPPMLLVFVSLGRWLEHIAKGKTSEALSKLLSLKPTEAVLVSLDENGHPVSEKSIPVDLVERGDVLRVVPGAKVPVDGKVLSGQSTCDESLITGESMPVPKTKDSLVIGGSINQHGALLVTATHTGEASTLAQIVRLVEDAQASKAPVQRLADTIAGYFVPLVVFLSLLTLICWMISGALNIEIIKRITPPVYVNAGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5W7</accession>
    <name>A0A835G5W7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="3 13">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="3 13"/>
    <dbReference type="EMBL" id="JACKWZ010000618">
        <property type="protein sequence ID" value="KAF9406257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5W7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000290">
        <property type="entry name" value="Protein-tyrosine sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="42717" checksum="95A5E0826FC605DC" modified="2021-09-29" version="1">MKLRSPSQGCGEDGTGCTGECPPCQGVYTSVGKGTSSSYVASSSCAFSADLLLANGLGEKAMGRGARWRLAAALVAGALLVWLWRGGARPAGAQRRRELNAPVEGRELPLIFIGGVPRSGTTLMRAMLDAHPDVRCGQETRVVPRLLQMRQHWLRSQKESVRLEQAGVSKAVLDNAIAAFCLEVIVRHGETAPRLCNKDPLVLKMGTYVLELFPNAKFLFMVRDGRATVHSIITRKVTITGFDLTSYRQCLTKWNHAVELMYQQCKSMGADKCLMVRYEALVLRPGATMRRVLDFLQLPWHDAVLHHEQYINQPNGVALSNVERSSDQVVRPVNLDALDKWVGQIPADVRADMAELAPMLSVLGYDPWANPPRYEATADAAVTERRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G620</accession>
    <name>A0A835G620_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000599">
        <property type="protein sequence ID" value="KAF9406395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G620"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="12077" checksum="BF2A45F0B3D4B0F3" modified="2021-09-29" version="1">MNYQMECKKKEEMKEDRNLFFFKSLLPSLATLNDNQTLEFQSGVLNLLQNIKNRNEWSPAHSSTYNYQPNVAQSQGYFTSQYQASPESQSIQSNASDLPDFHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G723</accession>
    <name>A0A835G723_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_018077</name>
        <name evidence="13" type="ORF">HW555_012454</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000457">
        <property type="protein sequence ID" value="KAF9407572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000281">
        <property type="protein sequence ID" value="KAH9640411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G723"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11826">
        <property type="entry name" value="SH3_Abi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028455">
        <property type="entry name" value="ABI3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF0">
        <property type="entry name" value="ABELSON INTERACTING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="367"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9407572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9640411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="425" mass="46079" checksum="90BC07E0BD767FF9" modified="2021-09-29" version="1">MAELAALLQTEIPEGRSHLTDSHTNLERVADYCEANYFQSENKRLALESTKNYTTQSLASVAYQINTLAYNFLQLLELQTMQLAEMEGQMNHIAQTVAIHKEKVARREIGVLTANKVTNRQYKIIAPANPEKPIKYVRKSIDYTALDDIGHGARWNGATSGTPRGRRSGSTPSAATLPAPTTKPPTPPAAVRAAAAANTGTLGRGTLGKSSREYRTPPAVAPPQVPSHYAPNYPRRPPGYSTLPVAQPQVGMVHPNQHQATSNYSQQDLHSSMPPPPSPLIGSDGEHSQHSMSLPGQRASSSSAGGGSIRGGSVSPPLPPPPMDDELAHDGFGRPHHMNNKMGAPYSNAVPAIVPDEEDLPGWVPKNYIEKVVAIYDYYADKEDELSFQESAVIYVLKKNDDGWWEGVMDGVTGLFPGNYVEPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G763</accession>
    <name>A0A835G763_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000330">
        <property type="protein sequence ID" value="KAF9409202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G763"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="273" mass="30488" checksum="735D9637AD89B730" modified="2021-09-29" version="1">MSSIGVVVFRNSPLGKSQVLQESVNNSVNISNNNGNQNSTREIIIVRKKQKNPSVPTTVSVTSLVRAADNALSTAPVAKKSRSCENNAEESVRSPTPLAVARRNARERNRVRQVNDGFAALRRHIPEEVAAAFENANSNRGANKKLSKVETLRMAVEYIRNLENLLNIGHDKENSSRPSMESFPSPASSSPRENSQERSYYSLHSPAIEDEDMDEDELDGSMHIPRQQYIDMQAAEQFQLVATPNLYEEEEGAGQPSLHHQIFWGMKRSLLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7N6</accession>
    <name>A0A835G7N6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000309">
        <property type="protein sequence ID" value="KAF9409567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7N6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="73" mass="8130" checksum="6F8D252D1295B56B" modified="2021-09-29" version="1">MRMQRNPAFPSAMNSGYKSFYPSPCFGPPRNQYSTGSYAQPTQPFQPSNCFMTASAIRKMSNTTSPSGFGRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8T5</accession>
    <name>A0A835G8T5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic receptor 75a N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_010460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8T5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032435729" description="Ionotropic receptor 75a N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9410458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="593" mass="67946" checksum="60CC0E6CE20B2364" modified="2021-09-29" version="1">MNLLCNLLLTLSVADVSLVIDIFKLKNIKNGVIFHCYDSYVVSNVHRILNEHDILMASAKIDYNTTYNVAESYPKVGLIIYTVCQGWTSVLDSENISFQGNSYVIITEDLSGTTEVLSRYPIEVDSDVIVAHKINQTFKLYEVFNTGSKYRGTYNVREVGLWNSSLVINASNRWNLQGVFVKTAVIILTLPKIVNQTIEQYMEKPIKSQIDVDTVHRMKYFIMLKFMRDMYNISYDMHRVNTWGYQRNGSFDGMVNALYQGMAEIGGAPIFYRIDRGQRVQYISEVWMSRHSFLFRHPKYPGGFYTIYTRPLSDVVWYCVVAMLAVTAIILWVMLVVQKGDNEESSICLAGLVIWGAICQQVSSLLLEPPRNIRTLKDILDSDLKVGAHDIVYDKDYFKTYEEVANNDIMLDGSMVKQHQLMFQRTTDPVAIELYHKKVATGTHYNFFTPEEGIALVKKGGFAFHIDTTFAFPLIKATFTEREICETNLVQMYPLQRMGVVVRKHSPYKEHIAYAIRKMYEVGLPPRIQSEIDEPMPECAHTPDSSIFCVGIREFSTPLLALAIGMVTSIIVLFCEIIFDRVVKINSVRDFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G926</accession>
    <name>A0A835G926_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9411998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G926"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="9310" checksum="D060481CF8757282" modified="2021-09-29" version="1">MVNAKIITLINGKKRLLYQSHTYFVRYETKNETRWSCSHFPKCKASLYANNNQIVTKIIGEHCHGTKKLYVSATGHYVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9S1</accession>
    <name>A0A835G9S1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein eyes shut</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000710">
        <property type="entry name" value="Blast:Protein eyes shut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="521"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="693"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="731"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="779"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="959"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="757"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1471" mass="159372" checksum="B0D610E43814FCE3" modified="2021-09-29" version="1" fragment="single">KSRSFLIMMFLGKVKGLLQTVWWLLAAAKVVTAGISCLSSPCLHGICIDDVNTTYSCYCVDGYTGVQCQTNWDECWSSPCQNGGTCIDGIASYNCSCPDGFIGDNCETNYNECESNPCLNNGTCIDMNNGYLCSCIPGFSGDHCELDVAVCNSTEEVRCYNGGQCIEGPGFKFYCKCLPGWAGPKCEDQIDECKSNPCQNGGVCIDVHADYMCACAFGFTGKSCEVQIEFCDENSCSNNALCVVEDGARVCYCVPDYHGERCELQYDECLLGPRCMNGGTCIDGVDNFTCSCPPRLTGPLCECLILDDESYDCEYVSPTPLTSSTQSVLTTLIEETTTPTVYTEMPSTYGPNDTTLLTTDSEAVPTTVTDTSTEKEPVFTATTVVTEIITKEDDISSTPEETTGTSESTTTKAGISELPDHEETRPTIESDNAKTDTTTDDTVSTSQSPTTDFTSSSTESTKFDIPIETTKETTVEGASTSSGTTPGITEEVPGDITTTPKTDCHCNFNYGGRFCDEPITITSAAFGGNSFIAHKLINATSINIEFNAKTLITDGQILHADIAKGVYMQLYMNSGLLKFKFSCGYQTMLLSELKTFVNKGYPMKIETRLDLYPEDQHCNATLRLNDTVAMSGGQVANITTLEHNSTLYLGNSRDVKDSESKPFIGCIRDLIVNGEKREVFGDALDAGEVTECLSLSCLSGPCLNGGSCSDRHDGGYTCSCANGWLGEHCNESVCENNPCQSGGSCVRHPGSGFLCLCPYGKHGILCEYNVEITRPALAPISTGISSYIMYALSPAAMNSDRFDLRLRFQTSDMDQIALLAFIGQSGRHDSRSQHLALTFVKGYIMLTWNMGSGPRRVFTSRALSPRRGGHAVRVWRRGRSAGLSVDGRYNISGNAPAHSTKMTLLPYIFIGGHPSPEFVDLPHDLPLHSGWRGCIWEVGGQAVGAGARAAGGRGVGQCGVAQCTAKSCNAPRGVCIHSPATYGCICNEGWFGATCSSNRNPCDRAHSKCQGQCVITTDGNTQCDCPYGKTGVYCDQDLIPTDVLFTGTRSYIQLHPTTISSVSLSLESEIKPAKERGLVMFVKTPHFYTALSLQGGLLEYRWTDRLSGVTSLVRSGVVVSMSQWHSVKAGRYGSRLYVWVDGSLSTEAMLAHAYPHTNGNASILLGGAKDLSSLPFDAMSGAPAPYTGCIKNFHACGGGVCILERGRARCACGASNYVGTGPRCRRHVSCQPSTCAPPRGRCRADRCICSTGYAGTFCDQKIDIKIPQFDGTSLVSLGRQSTSSHTNQQRIAPTLSRPSYVALNFTTAEPNGLLLWIEMSNDYVGLGLENGYAKLVWSFNQNIVKTAKFNYGDLIASPRTLSRLMPHAGYLSDAEWHILVLQINKTNITLTADNTLVYTEEPGLNIETEYDDIDMFIGGISDNDYEKAKKIFPKNFKGCIDQISTREKSFITNYTEVYSENVKSCQLYPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAD0</accession>
    <name>A0A835GAD0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000216">
        <property type="protein sequence ID" value="KAF9411706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAD0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="222"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9411706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="416" mass="45443" checksum="8A2D82AB8A879E59" modified="2021-09-29" version="1">MDIFGDRMATTIAGSGNYRDLSKPDKQGFNELKENLQNGKTTNGYVKSNDFRNGDTKFSLSGGGIPKMDWSKYDTFPGSFEKCTLLTAVLTHFGLYILMFLGFVNQLLFTPKVATEKNREIMCWLAQVHGHGAALHQPGLVQLPRAAIVVGMGFGTNTLGLPGLLGPGSLALSDEKNHASLIMGLRLARATVRVFRHNDVRHLEQLARAAIAERKWTKIVIAHSIGALGSRGRGVCDHAGVAPRDVDVLMGTFTKSVGASGGYIAGSAKLINWIRQYGHMHTYAHAMSPPVAQQIVAAMRLLDEPAGRARLLALRDNTHYFRDELRRLGVVTLGHPDSPVVPVLVYTFSKMAATVERLTDSGVATVGVGFPATPLNKARIRFCLSASHSREQLQRCVEAVARAVRELGLDYSRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAW5</accession>
    <name>A0A835GAW5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000213">
        <property type="protein sequence ID" value="KAF9411771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAW5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38352" checksum="F6A4B96BA7230AC4" modified="2021-09-29" version="1">MEGGGRQSRLLSRLLSRLRGDHHKYDTLEKQFSFSTADNRNLQENTARSARTRNEPKSVFYFNIKPSSNEGSSCVQHEYSGQYLTPEQLPEFCDQLHNLVEVIRNIQTYAKVTGEYPSELERRLEQEAREVAAIAAEARNARDVVTRVRAQRRAVRAHKKHLVSQLATLRETEVRELESTVRLSDRKLFKTWEALKDATDPAAFEPLLDEIKNKQAALECLLRLVDSKQATLSRTAPPPTPLPPPESTLDTDESGATGGSCGAAGRNRHDGRRSAGKRRRRSPRSVPLSGEPSRHAPPPQVTLYIQGTESTSRYRVGSAGAVALTPLELPSGGSVRDILFFTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB77</accession>
    <name>A0A835GB77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9412003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8908" checksum="1AC0A5D7E3E13463" modified="2021-09-29" version="1">MEKPYYLNMRSKKKLLMYQGYTFSRYAPRYFYCSKKGFGCKAALVLDHDGSLVIMKNAHNHEPPNYTCINGIHIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBI1</accession>
    <name>A0A835GBI1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBI1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="648" mass="75219" checksum="9B804EEEFE379793" modified="2021-09-29" version="1">MNTPIALYLAICMKAREGNLLTNDTFLSAVYMDPRDRPTDENDLNQDNVPHTSRRRYRERQRERSTEHFALFFIYYSLGYSTNTALATPPTQLCEREGDRVTFSLTQVCALHWNCAVLLYNLTKPSLSVSVAGDVRRSHQDVVRPVNENKNQPVIVLDQAEVQPDLAVVPHAGDQRGAVVDEQDIQHSIIHLPHISRPPNTSNSYIIFGCTGETRYRIPKHMKIRLLKDFNYYPPPFARVCEEHLLLNDFEILLSARNVSHDFNEAHIMDMMQILKTMPQEGRVDFENIETMDPNEVYFLTGRSFEQFNRMFVETPSLSRRSKRPKTALAAYLIKLKTGEPNTRLADMFHISRTTLEREMTTTRDCIKEEFTPLHLEGEFLILERGFRDAVPNVESCGYDAHMPKSSRLVTICRWVVEVVNGRFKRDFKIFRQDYFNRALPHMQDDFRNAAAITNAFHDPITDNVNASGFMERINNSHVIDYNLNSRRIPFQSMSVELPDVRGFPRLSEEELVMFALGTYQIKLARSYYSEHARNGVYTIEVYRENDDLNNLLNNYNITGNNFWLLRGEVQSRHTRSRIYHTYILVNSDHLKLAALNHYYCSCKSGRRTLGTCAHVMSIVWFLAYARYENIDHPAQFLDSIVIDENDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBN4</accession>
    <name>A0A835GBN4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000243">
        <property type="protein sequence ID" value="KAF9410860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBN4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF41">
        <property type="entry name" value="UNC5C-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="3">
        <location>
            <begin position="448"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="581" mass="65274" checksum="8B176DD85C8D20F0" modified="2021-09-29" version="1">MLRTRLTPDSSYSTKEEMLRQRFSESPYSTKEDMLRQRMDLSAKEPLYGKRTYDPPPSTSWNENHYGVRPDRRLQTPVHFPGRLSPMSKCMSEPPYATRTEMMARLGQTESPYATRAEVKSSFSDTQYGPRHDMMDMRPDVRPASAECTYVSKQEILSQKAALLAKKESSYSIRLEEKLEIIKQRNQAKKEMIYQTRKEANESDSVKIREPLYVSKRELKESVIYESHQETKEVAQPEEQEGSSSSACSARSSPYELGDANHLSRREPVYQTKSEAESGIESETFQEIDFSKLRLTESKTDAEKQKSKNLESSILKGEPMYAPRLHGKADHISNALKVTTSPVPYESTTSMETHYASECSMNFENKPQSTPYTSQDLLERNNKPSRSVTFCEQILEKSPETSGENSQSMSSSQNETTVIQQNTTMVPSSADANDSTSKPQEVEPDGPHTTWGIFDSEGGVLEDRQWGVSLIIPPKAIAPGIKQKIYFTVSDPRLSQRVGGPPIDMDNGEAMLSPLVMCGPQGLVFLRPVTLRLPHCANAVPSLGLTIKATDTEAHLSTDWDQIHLPATTTLNTVAVKVDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCK8</accession>
    <name>A0A835GCK8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DsRNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCK8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000007">
        <property type="entry name" value="Alkaline nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="6">
        <location>
            <begin position="193"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="7">
        <location>
            <begin position="584"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="7">
        <location>
            <begin position="943"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1199" mass="133412" checksum="4D6F196B49C3AC60" modified="2021-09-29" version="1">MDLLDIANDTQYNRRHNESTTGGDFGIHCRRKYEIAVQGVPYSNMRTVLVLAAFLAAAVALPTEIPEPGCTIRINGDLGQPQPVYLRGGNRYMAADGNSGQVRLNTGEQVVIACTGSGRTILHPNIAASRDVATATCVNNNLVSGSGWLNGNGAFGQLTCSAHAFHEAQATSTRCWNNNIVIRVGFIVNNVFYPLYWSCFDQNRLEVIYVWYDQTPENAVHQTGVDRPSWLAGSFFPGVAVNTMYTQVNQKAVVTQYVGAALADKYITSHQFMARGHLAAKSDYVFATGQRATFYFINAAPQWQPFNAGNWNWLEQNLRARIGAAGYNTVIYTGTFGISQLRDQNNRLVDIYLVPERNQIPVPLYYYKVVYDAGRRLGTAFVSINNPHYSESECKASEKMRTVLVLAAVLAAVTALPTEIPEPGQLALVLGEEDFEDYLDAWLELEQSKSANASIEAGPRSGCTFRINGDLGQPQPVYLRGNRYLAANGNSGQIRLNTGEQVVIACTGSGRSIRHPNIAATRDVATATCVSNNLVSGAGWLNGNGAFGQLTCSAHAHHEAQGTSTRCWNNNMVIRVGFIVNNVFHPLYWSCFNQNRMEVLYVWYDQTPANAVHQSGVDRPSWLAGSFFPGVAVNTMYTQANQKTVVTRYVGATLADRYITSHQFMARGHLAAKSDYVFATGQRATFYFINAAPQWQPFNAGNWNWLEQNLRARIGAAGYNTVIYTGTFGVTQLRDQNNRFVDIYLVPERNQIPVPLYFYKVVYDSSRRIGTAFVSINNPYYTLAECRARQFCTDRCRNNSAFNWLRWQPDRIDLGYSFCCTSEASSKMRTVLVLVAAVAAVTALPTEIPEPAQLALVLGEEEFEDYLDAWLELEQNRAANYSNVEAGPRSGCTFRVNGDLGQPQPVYIRGNRFMAPNGNTGQIRLNTGEQVVIACTGSGRAIRHPNIAASRNVATATCVSNNLVSGAGWLNGNGAFWSAYIWKLLSGVAVNTMYTQNNQRTVVTRYVGANLANRYITNHQFMSRGHLAAKSDYVFATGQRATFYFINAAPQWQPFNAGNWNSLEQNLRARIGAAGYNTVIYTGTFGVTQLRDQNNRFVDIYLVPERNQIPVPLYFYKVAYDASRRLGTAFISINNPYYTLAECRARQFCTDRCRNNSAFNWLRWQPDRIDIGYSFCCTVDDFRRTIPHLPSFSTNGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCV4</accession>
    <name>A0A835GCV4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_016653</name>
        <name evidence="3" type="ORF">HW555_008580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000172">
        <property type="protein sequence ID" value="KAH9642848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCV4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9642848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="331" mass="37197" checksum="BA64B66164DE0E3B" modified="2021-09-29" version="1">MEILSQVTNTQFMFTAAAVAVVLVCAALVFVFGFRSAEQPQFDKLPLVLDDRKSSNKKNKKKDKKSSPNRVVTDDVKTKSENSKKSPSKEKKEEKVKEVEKPKPKERPTEPKPVKKEIGAGDAKKGKKNKIVVEVEKPADFDDGGWQEVPKKSDKKKERKPVEEKDKKKESPAKKNKKVKDADVEAARPVEEPVEETIKVISAEGPHVDEDAARALQAQVEELQRVLKEAERREQAALGGVEDESPEVEELTDVKDLRSNKKKENKEKQIRKKSVEISATKSVPKQDSVEKDNSDSEKQDSQNALAFDELGDTWTDAKVSKKSKKKARKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCV8</accession>
    <name>A0A835GCV8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000214">
        <property type="protein sequence ID" value="KAF9411754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCV8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57619" checksum="9F7F4284E400D155" modified="2021-09-29" version="1" fragment="single">MQLQDELMNNLIKAERNFKKTPKDRMKRQYLETRLEVLEQQYKEFKEQHKIILSKASKEKKETYFTEGFYENFEELYVQYKTSLREALQQFMPPPLSQKINNESAYAIKLLLDTTSTCLKSLESIGLSTETWDVIIVYITVAKLDNESIKQWEQKLSVSSDDFPTWPQLKDYLEYRFRSLEMIDDANAQRSTQAAKQELQPTRVLLAMARVKVFNSNGFSQIIRALIDQGSQASLVTEATVQLLGLTRIPVNGFVSGLGDGHTRIKHRVSLQIQSRYNPANIIQVNAYVMNSLTSMLPTTNLSSHEWVEIKKLPLADHTYATPSKVDILLGAEVYSEILLDGMIRQSQGTLLAQNTVLGWIISGKVSNGSISAAKDNLTSLHVCLEENDLLKKFWEMENEPNMLQKEMTESEKECENLFNSTTTRDDEGRFIVRLSFATDNPKCQYGNSKEKAIKMLESLERKLTRDPKLRIEYNKVFEEYLSLNHMTKLNEREIENTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD21</accession>
    <name>A0A835GD21_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Osiris 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_011837</name>
        <name evidence="3" type="ORF">HW555_008390</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000162">
        <property type="protein sequence ID" value="KAF9413349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000073">
        <property type="protein sequence ID" value="KAH9644668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD21"/>
    <dbReference type="OrthoDB" id="8194491at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF1">
        <property type="entry name" value="FI01546P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033034326" description="Osiris 9" evidence="2">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9644668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26368" checksum="32D802D2A6140863" modified="2021-09-29" version="1">MKTFLVFLVCVVAVYCKPATSEDDVLSNVVGVVKSCAEEDVWMCIKERSMRFLENAASARELKLADGLAIYNVGTSRSARSYEPLPEEPQARENQVEARLVDAAADFMENHVIQLRMPKSTVEDMKRSLEEGRGKKKKLKQLLPILALLQLKIQSLIPLFLGIIAFAAIKGLMLAKAALLASALVLLKKLLSKSEHHESYEVVAHPHHEEHFSHGGGGHGGWGRSSQDAQSLAYNAYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDH6</accession>
    <name>A0A835GDH6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDH6"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000012">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="156"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="528"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="603"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="796" mass="90367" checksum="743062C64CE83376" modified="2021-09-29" version="1">MDLAKSLFSSRDHVGYVGREDHERKISAALADDDPEDMIDAIRGLNIADELLPAPGGPFSALTPSMVPQDIMAKLAQPESEGHGGGLPDYRFDEFGFCVEEEDGPEPSSNKLLADAFVEDDQHRLQWEFYSKEINFSEGEGKLEKTDKLQKMVKDGVPHSLRPQVWMHLCGANKKRASTEITYHEIVRASSDDGLVTSKQIEKDLVQILPNNVCFSHPTSTGVPRLRRILRALAWLYPDIGYCQGTGMIAASLLLLMEEEDAFWIMCTTVEDLLPASYYSSTLIGIQADQKVLRSLISTYLPGIDQVLNAHDIELSLITMHWFLTLYANVVHMKILLRIWDLFFLDGSLVLFKITLAMLKIKENRFTEISNSAQIFNALSDIPGEIDDVDVLIKTIDEVCGDTLSPTLIDTHRRRHLAYLMADQGALVGNPSAVPNLPKQQLQRRQIKKSKSVIQTILFGEDSNNEDAVSKNVKQTEILVDLREAILQVARHFLALEPQLASEVQLTADYTMQSHAADRERYVNVSRSKRRRAKALLDFERRDGDELGFRKNDVIEVISSRDEHCWIGELNGLRGWFPARFVKLLDEKGVKYSRAGDDSVTEKAAHLVRGVLAPAFKRVLLHGIKRPSFLDGPCHPWLFIEEASSREVEKDFNSVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINLSHDNAHAQMDVKLRTLICMGLNEEALHLWLEVLCSCVDVVQKWYHPWSFINSPGWVQIKCELRILSQFGFNLNPDWELPLKKDTQNQPLKEGVRDMLVKHHLFSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDM2</accession>
    <name>A0A835GDM2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000150">
        <property type="protein sequence ID" value="KAF9413805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044714">
        <property type="entry name" value="AtSIBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46672">
        <property type="entry name" value="OS08G0495500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="29358" checksum="E72F1F1B38ACA2EE" modified="2021-09-29" version="1">MFEQHLPVLEPSVNQINAAPPDVVNGHRPCQTREVKWLRLDKIYQKFYRPNFYDIGGTYTQDVPDYWFSFKTEQVGTTFLLHLFIRNQGVTSFNVALSCGNKFIVDRKAETVYLQHYLKEFQFRQVSEMTHTYLTTYNFSELDIQCLKDRKLHIAVSFPFTESMDISLEVINNIKLNHDCSALFADPIGSDFVIESADGVKFPIHRVILTSHSEVFKAMLKGDTAESQNSYVKLIDVSGEDLRYMLEYITRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE05</accession>
    <name>A0A835GE05_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15291">
        <property type="entry name" value="7tmC_GABA-B-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002456">
        <property type="entry name" value="GPCR_3_GABA_rcpt_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="613"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9415381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="926" mass="103896" checksum="A63284AFC5BFCD81" modified="2021-09-29" version="1">MKAERAWKMRREVNNDSMSPPRAMTLQGAKGRAVAAAAGRASPGPRAHSMPYFIENLTLIRLCLQYLRVISRLYQNVAASLPRVRVNFNFPKRPLVKLKTDVDNMFSFRTRTVYCDIKALLVKTIVQLFVVAKCVVLRWRCRGGGARRARTLLVLWLSGCGGGGYSEGRRDGDLHIGGIFPMEGEGGWQGGQACKPAAELALADVNARSDLLSGFKLYIHSNDSKCEPGLGASVMYNLLYNPPQKLLLLAGCSTVCTTVAEAAKMWNLMVLCYGASSPALSDRARFPTLFRTHPSATVHNPTRIKLMQKFGWSRIAILQQAEEVFISTVEDLEAHCKKAGIEIVTRQSFLSDPADAVRNLRRQDARVIVGLFYVVAARRVLCEVYKHRLYGKSYVWFFIGWYEDNWFETNLEKEGIDCSPEQMREAAEGHLTTEALMWNQNSNQTTISGMTSEDFRSRLNEALREAGYDIDGERYPEGYQEAPLAYDAVWAVALAFNKTMEKLEKSGLSLKNFTYTNKKIADDIYEAINSTSFLGVSGLVAFSSQGDRIALTQIEQLTDNHYVKLGYYDTQADNLTWLERERWVGGKVPPDRTVVVNELRTVSLPLFACMTALCIAGILAAIALIVFNILHRHRRVIQWSHPACNTVMLCGCCICLSAAIALGVDGRWVMPQHFSGLCAARAWLLATGFSMAYGAMFTKVWRVHRHTTKPKVETKKKRIHGWKLYTMVGGLLVVDVALLTAWQLRDPLERRVETFPLEAPRHHDDDVHIRPELEHCESKHNTVWLGVMYGYKGLVLVFGLFLAYETRSVKVRQINDSRYVGMSIYNVVVLCLITAPVTLVIASQQDAAFAFVSLAIVFCCFLSMALIFIPKVIEVIRHPTERAESGRGSGSGSAPADEERYRELVKENEELQKLIAQFLLSCLNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEA1</accession>
    <name>A0A835GEA1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000157">
        <property type="protein sequence ID" value="KAF9413506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEA1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032607284" description="Lipase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9413506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="47895" checksum="78A409C25D6A2519" modified="2021-09-29" version="1">MVLKIVLFVALAVSASARRPPNANYAEGLLKNSPASRMSSDIEEDINLDAPGLVAKYGYPIEVHNVITSDGYILEMHRIPHGRDHNNKPDPKKIPVLVMHGLLSSSADFIVLGPGNALAYLLAEAGYDVWLGNARGNFYSRKHRSLNPDSSINHNFWRFSWDEIGNIDLAAFVDFILDRTGHEKLHYIGHSQGGTTFLVLNSLQPKYNEKFISFQGLAPASYFEHNEVALFNSLAPHESTIETTAFLLGQPEIFGNRDFVYWIRSTFCNGITSLLADVCDMEFDNLLDPEHYNATMIPLFLSHAPAGASVRQVAHYGQTIRFKAFRRYNHNSITNLGVYGSFNPPAYDLSKVTVPSYLHYGQNDKEVHFKDLLTLAATLPNVVGTYKVERDTFNHFDFIWGRDVREQLYERTLIPLMKQAERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEL8</accession>
    <name>A0A835GEL8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_007315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEL8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF4">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="591"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="965"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9414924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114081" checksum="7FAC9614DA4B76E0" modified="2021-09-29" version="1" fragment="single">TVLQDKRVSPPTRAQAARAHRLTPIAGPSGVAVPPSCEQLPVNARVASAMTRDTYEMKPNRLSRGSSLFGADPQVQLRTALLANDFATFKKLVSYGTVDLEHVYQYPDYKTCLEIAVSEPNKQDFVKLLLQHEVEVNKVNETHAMAPIHFAVENGNIEALRLLLEDDRIDVNIKSKGNTALLMAIKHIEDLDDDRERDLAIYEDMVELLLKAGCNANSPDSKGVTPVHSAAKQGLERVVTLILDYTKEPVHLDAYKDIRGRTARYYLEQAFPHLLAKFETQEVEPEEITVDKLFSYLSRHEEDNFIRDFTKLVKKNEHRTALAANNGMNTMLQMATEKGMYRVVGTLLLSGADPNATCSGNTSRPIGIACQYGHYKILKMFVDNESTLFDPVNGESLLQITVKGMRSYSNTPKENFNDCLQLLLKHPKVNININHPDMKDNTALHYAARNGDQDTVLELLRNGACVGLRNKFDEPPLADINAKTLETYLDECVTTNSQRPSDDDYEIHMKYSFLVYPNNSLENELCKVPLMDNSSTHEKELDSLLAPETDALLYMTRNEDLRPLLKHPVITSFLYLKWQRISCLFYANITFYSLLWLCLILYIMLGYGVEKKQSKSIEALNVITHVGAIIGLILLIFRELFQLLVAPTRYLQSLENWMEIVLIFVTALVVGNDSAAESTKQQLSSVAILLSSAELVLLIGQFPTLSTNIVMLKTVSWNFFKFLLWYCILIIAFALSFYTLFRHEQEDEDQKAPDPNNTGKEEEEEEDFFEDPGRSLFKTIVMLTGEFDAGSIKFSTFPVTSHFIFIVFVFMIPIVLFNLLNGLAVSDTQEIRADAELVGHISRVKLISYFESVLIGSAKSYGKPCTCWSWMPASFESLNIIKPKMFCMKPFAKRISLFPHFLPKYRIIVKPNQDNKIEIPHAEPLKYGDDYEDIEGGAGGCCFERCQNYRLDRRIVKNAKQVVSKKTQITEFDEIKNQLSKYERKIEDLEITMKKVLQALNSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGK0</accession>
    <name>A0A835GGK0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGK0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF23">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="688"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="845" mass="94230" checksum="ED0B1A78AFDE71E1" modified="2021-09-29" version="1">MTLKELFKKFLLGIESWFETGLWYTLEVLIHNESPNVLTSQGFAQKYAKIPDKKLLAQKTTPSKTNSLASSRSNSKDDNSDDNISQSSVGGGIKDKLAALFNKEQTISESTIANKFKQEREKEMEMLQNRFHYKPKQEKQESPNDSDDDTSEHDPSEKAPLMGSTVSLSQTNKKPEIISNLPKVVFDEKKSEALNDKEKEIEKDERYLDDVKRIKVNNNKKEPQTNGAVLQQPASLYPHLSDIETDTSHNQDEYSDCGGSSSEDNVQENTRDRLNKSDNWAETSFGREVMNGYNLGAPLLVVKKNNTSYKKAVRESDSDSSGADSELDDILDEAINEQTEGPTPPKLNKQSVESSSSFVYQEHSAFKSPLKVQQTTPARHDKGSELVHSVSFYRRMQNQSTTPSTPMRVVRHVSPEREPPATPDEPAASVTTVRERIKELQNEIAKQQTVISQASQALNLCAATIEFSGSTEQAEGERLLLLATHRRQACVHEVQRLQVEGAGPAAARGMASLHLANLTLPLKRDYIRQLNADGAVGHHAVCLVKCRDRVLASSMQQSAPTAAALHFPDDIRMHGLASDFKVTVEVYLLQASKEVLSHEMKYHISNKKSSSKLLTPKSKISELKAPRVQSPAGPMAVRSPQFALHGYCIFALQQSTRKHFTLNKVPCGSPLEGSLNLEIKARVQVSPPAPHAAFLTAFDDVSGLGAWHRRWFRLQPPRLAYWKYPDDVQKKTHLDLCKIVIILVTSNDLSYMPIGDIDLSTVISERVIKAPRDLCARPNTILLESSIPAGLIVPDSGSLVYFRRPDGSIVRRHLLAADTPKDRDIWLDCLNKALEYVRCCATEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIU8</accession>
    <name>A0A835GIU8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57958" checksum="5B381CF27AFAD72F" modified="2021-09-29" version="1">MGFRIIIAGESQCAAYAETCLLADYLSRNLPNFCYHCIEVPVMDWKTWLCKVNVKNKWHHMESPIVWKELLMKGSKAQYIGGASDFLDYCYSYYNFDTLFSSEKYDGLLNNVLQFKRKLHIEENLHILDADKRPTLDAPPQKKFVVTISGAGHLLAMHLISGLVDHAIMASDNIIHKIYLYDQSCTPSFMNYIEKECSYVQTDNPGRDIKCVSKIGVALTYTDVLIVLDHEPFDKSKPMGAWLRQNRNKMKELALMINASGSRKMYIIFPNLGPACYNATILRNSVNINKNNIVVATSDVGVEILPVVAKVAQVPMRNIFCPPVWGFIGINQLVDIQTTIHVYNSFNPYKRYARVRHSSLNIGSITPETRLLDYLMHFDETLWIKVAEMKEKFGHGQARLSKAIAVISLVNLWLLNPSPDHIVSLGICCDGSFGLHFDGIFSQPARFVDGRWKPATDFLMPKDRQMKLPYLIDMAKLVMKMQPNDLPEIQQYYPCICKKKNYKIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIZ6</accession>
    <name>A0A835GIZ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIZ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF88">
        <property type="entry name" value="DEBRIS BUSTER, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43599" checksum="68F9B02CA73595AF" modified="2021-09-29" version="1">MVLPRTLLLTYFFPFLDSDLLLPNLGSWVFNLLVSGLAITYRDRAKPFVHVTAEELVFGYNDPLVTLAHYFYPKGKRPNSQMGLLLARNGTLDEVSTMYTGQKQLDRFGYMDRINGLDHLPHWKDRPCNDIRASEGSFFPPRSVTKSDIVHVYDKDLCRILPLQYRKDVYKDGIKAGLYTPPASTFESADVNPDNKCYYPGEKCPPRGLQNISPCQYNAPVYLSFPHFYDADPALLEPFEGLKPNKKKHETYFMIQPKIGVPVEGFVRVQLNLKVDRAPNIPINNINNFPDTIFPVMWIEEGIHELSTPIWRWIYLATTVGPVFAPIITSSMIIFRFPNPGCHLHTSLQKPSHRAKFFGDHGDWEANYKTEFNADYQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK13</accession>
    <name>A0A835GK13_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Androgen-dependent TFPI-regulating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_004228</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK13"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9419143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26391" checksum="C33D9BEDE9A4D678" modified="2021-09-29" version="1">MASADLSNRYTYPRILGYSVSLVLHITNMYNMLAFYEGEVLEDPFCMQVMYLSLGLSCDVLTITNHGKESSLLKSLKTIRDPLFTCLVWPYAFTVCVSFWTIFSYDRALILPPSVDKTITPITNHILHTSIVPIVLWELLFRHRSRPETHLGNLLTINLYAALYLVVIIVAFLEQGVWVYPILDKLYGTIHFYLFIGAAVVITNIFYKLQWYLTDLVWNRSEDTKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKC4</accession>
    <name>A0A835GKC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25555" checksum="58845715691CE07B" modified="2021-09-29" version="1">MAGKSVIVGNGTQISVKGSGQVAVQVWNGNEWIDTTIDNVLHVPELSTNLFSVNRATSKGYVIVTGENECKFYKENKVMAVAKRNGSMYYLDFRYHNTSEANVAEIKRSTLHEWHEKMAHQNMSYVKEVLKNNKVDINTQSSDSATCESCVKENKEEETKSTTVPCVYKQMEEFNLDEAEDRAQVVEEDDNTLSISESDSEGSLYEPSDSSEEITTSLFHTQSYLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL54</accession>
    <name>A0A835GL54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="6">2.4.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Core 1 O-glycan T-synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Core 1 beta1,3-galactosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HF086_008896</name>
        <name evidence="25" type="ORF">HW555_004863</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BAW_Kor-Di-RS1</strain>
            <tissue evidence="25">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000058">
        <property type="protein sequence ID" value="KAF9418244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000868">
        <property type="protein sequence ID" value="KAH9629380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL54"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000017">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="24">
        <location>
            <begin position="92"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00059245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF9418244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAH9629380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="356" mass="41251" checksum="48662354892EFCF0" modified="2021-09-29" version="1">MNYVQAEGRVMGRRFFLTLVIGISAGFSFAYILLTSTGFSRQTAWHTYRESVRDLDKHPITAIGEHSNDEPAHKDEDRSVADELSRRVRVLCWVMTQPKNHEVKAKHVKATWGKRCNKILFMSSVEDPSLPTVKLPVSEGRDFLWAKTKAAFRYVYEHHRRDADWFLKADDDTYVVVENLRYMLADYDSKDPIYFGCRFKHFSPQGYMSGGAGYVLSREALDRFVNKALPTPQLCNAGDQGAEDAEMGKCLDKIGVRAMDSRDELHRGRFFPFVPQDHLFPNRDKDFWYWNYIFYPTDEGLDCCSDHAVSFHYVGPQLMYVLDYLIYHLRPYGIKYGSGVMPKILRGNDTKDIENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL89</accession>
    <name>A0A835GL89_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002782</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL89"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF285">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="336"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="426"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="687" mass="73667" checksum="C440A59A1AAB7736" modified="2021-09-29" version="1" fragment="single">SRLGVGMASMSSTLVETVSINYEDFNESFLTCGTCLCTYDGGEHTPKLLPCSHTVCLHCLTRIAASQTRDAGSFRCPICRELITIPRGGVAALPPSFLVNQLLDLMARQRREVIPQCSSHPGRELLFCETCDCVFCRHCADGPHSDTPCDHTVVPFSIALKRMSEILLYRANECLSKLGSARDAVASELRRLEAAATAADEAIDRHFAELKAAIDKRHSELKSAAAAAATHKRKLLEEQLKLIDAEKAKVEAECSGLQQQVEVREVSSRAAALGARLGDAAALAEPRENAFLAVDFAHNDAQQRFSEALAELGRVRTSTTFPGLCTLQLESACVCGLEVVVVLRTVDYHGEARCTGGDPVSAAATIDDAPLPCTVTDLDTGLYRITMRPWTAGALCVRVLVFARGVRDSPLRAQVAPTAAPLLVWGSRGTGKEQLSQPVALARCPKRREIYVLDAGNSRVKVLDDETFAFKTHIVNEGLAGRSCTGIAVTAEGIVAVNWRTRTLTEVSGEGATLRTIRSDRLQEPVCVAADLASRRLAVADNGARAVFLFDSHGNIEREVGNGELGLVGGIALSEDLLIIADVAIRVYDIEGNLKNVFAPVPKGRGGYGGIALATSSEGGTRHVVCARAVRGRPALLVLEPGAGKVLALSELADKKPRRVAGLTLLPNRRALLADLAADCLRLHTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLB3</accession>
    <name>A0A835GLB3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLB3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="122837" checksum="948B930FCC62BDD9" modified="2021-09-29" version="1">MDLLKTPSVQSLLDSDLESVESLQYLDIEELDEIEYALPASEAPTLAEVLSTEEEEIQSNETKCVEDPAACSALQVEFLQGISQQLLQAQDRSSAGAATALSVGNDSKLTVGTAHGHLLSFQEQTLRWVCDSNTDRGAVSCLAYNQDCTRLLAGYARGLICQYESVHGTILRRVTLGGELWGTLRVTWAGTSGLALDTGGSVWLIKFSRPLGVRSARSSCLFSGARGEVVAMAARDARILALATLSRVIIVAGGRAAGLKLTGPPDTLPVLEWSETDERVLVCGRSKTLQWLSLTITGSSICLKPIRRVELMTTPLWLGWLGGNLAIFDSDENLRLWGDDYDKPLDLSHMEPVYASSFFKGHWTDGRVSRAMCTAGVSALGGACVSAGTLSLLGRRGIVRVRPRHLLARAQAFLASGRHLNALRLLCSAQGAEAKSVAYQFIDNISERPYILTNKQVADHTVKLCLKYNLRDELWSRLWEQCSDEKAFVEAIAEATARGELSTVELSPSPDSTQALIEKLAEFEPDLVERVIASLPLTSIDPHRASVLTREKGLWRAVGAIAAALGGGGGAMRSLAAHVGSCGAMSEGGRCAGGRCAGAALVVAAADALAGRGAAGRALPAHARPSARHDALHALLACDENENGGRSPLRIMVEHDAAAAVRLLEQSARDPPFVGPLGKQNKLRVARALLSFARDLPEIDDRADVLEFLTGQLHANALPSDQEVINSLRELAAITNCERADRAWLAIITRGRVQNEQLEEQYMAADRRPRVLWRIDAILGRHERALEQFFNIMPPSNTDIDELFEFLRPLMDGNDDAKKLLESYLPRIIKLRPRAAACLAGEYLAEIGASILQTLNDEQAIEFGQSLLEAGHLHGEAAAAHLRNLCRQRPNDVRPFLADNVGLLRPEEALTIIRTEGPLEAEPFCLEAVGDPGAALDAILRLALKTDDEQMSLRLVTEAGELCSRAASTVPPDVAADMWARLLRQARAPPPALLLEAAAFLPAEDTLRGACEAPGVALALLACAASRRATWQCTARAAAREAHAALARALAAARRGVAVRGRCVRCSRRLAERAAVRTGHCARATHADCEPELCCGQCGRRVPTDTVTLAPRPLRRRSPQRESGLLLVTPSSLDLDGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLI3</accession>
    <name>A0A835GLI3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tripeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_003420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000003">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="35"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="13">
        <location>
            <begin position="532"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="14">
        <location>
            <begin position="675"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="12">
        <location>
            <begin position="799"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9420359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1221" mass="134431" checksum="AEF4CAA45AD3EE4F" modified="2021-09-29" version="1">MADAPIDCVFPVWGLMPKKETGVVSFITKNPIYDGRDTVIAIFDSGVDPAAAGLTVTSTGETKVIERYDCSGCGDVDTSTVIKKVTDGCITGLTGRKLKIPETWKNPSGSWRVGILHPFSIYPTKLKERVQEHRKEHSWDIGYKPAFAEANKNLQDFENDVVSKNPILSPEDKIQKEELEARVEVLQNAEKKYNDVGPTYDCVLFHDGNVWRACIDTSECGDLASGPFLGEYSVTHEHTHLTPFDEMTISINVHDEGQTLEVVGMCSTHGTHVAAIASGYFPDEPERNGVAPGAKIVSLTIGDSRLGSMETGTALVRACIKVMELSKKMKIDVINMSYGEHAHWSNSGRVGDIICEVVNRYNVSWVVSAGNHGPALCTVGAPPDIAQPILIGVGAYVSPEMMSAAYSMRARLPGGAFSWSSRGPTADGAAGVSVCAPGGAVAAVARFTLRNSQLMNGTSMAAPHVAGAVAMLVSGLKAKNLAYSPYSIKRSLENSANYLSHVEPWAQGCGLLNVEKAFDLLSEYSSAPERDVTFSIQCGPSNAKGILLRPRIDDVPKDIGITVEPQFLQNHNDMENISVIPKQIAFGMRLALTCDAAWVSCPQYLDMMNAARPWTVRVDTTGLKPGPHFTSILAYDVSAVSKGPVFRVPVTVLQPEPIQLGGAAPASLVAQDVLFQPATIVRHFLIVPPEATWGVLKISTEDKEKTGRFLIHTMQLLPKRSCRCHETQKMVNVTSEAPASLHFQVVGGVTLEVVIAKYWANLGEVSASYSVELHGLAADFGQRLVLGAADGLRAVTLRALRHQDLQPAAQLKYSEPAVRPSESKIVPLTARDVIPPSRQIYQLVNTYNFHIAKATEVSPIISLLCDMLYESEFESQMWMLYNSCKQLMATGDAYPSKYSVKLEKGEYTLRLNVRHENRALLDKLADLPAVIQQRLPAPIALDVYCSQAQALTGGKKYSSGSLANGNLLPLYFTTIPADNLLEFLLRRVRENIECRKGDKLDQVYEELVEKFPGYLGAHIAYLNALDSPTDPKKLPHANEEPDVTTAWCEQLISISDKTTKVLPATNDTINSMLYSQVIKAIDQDKLLAYLGMKNDTRSDAHKIKQAILILCDQLKIRYHRTKYIDLIQNEGFRICWVAGPKTEAYETPPVEKAIHYGVWHCFTFKQWGRAIKLLMKIQEERPSKEVEERLIEAYQQLGWDFYAKAAQSALPIKYPANYRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM93</accession>
    <name>A0A835GM93_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="436" mass="50460" checksum="110271F40398796B" modified="2021-09-29" version="1" fragment="single">NIEWSLLSRVKSPVEHLPEATPDYVLPKNIYRYEPYRGHKTLWAPTHTSGPTTQDSRTLLRTRPPINKPQNYKETPRQETSTTTKRHFWHHFDDAAEEWPKVILITTSTPRLTSKVTRKKTFSTYFPQLRLLPIDENETEIKDADNDDDQNYVIGSDKSTMKDKQKSMPDNEVEEMAEDYDDIQLSSVTKGANTRTYAYLRNSSVETTKLLQTTIRETTTLATTTQPEPTELKNEEKIEQNTQSGTQSEELEPRNENLPNGKNRKCYQCGLNLTGIPHEPTCHQIFDTTKRRYQYLKSQLKVVCTGPVWRRRSNRIKRAPSYDVSPRKLYKGGCFMRFLDVGEVYDERGCRTMLPLPGKSYASQRFTALEKSMHNMTDGCVTSPQASLTPFSRSISLYARYHVCVCTTDYCNNTHYCKKSLFLLIINIFTNIFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMI2</accession>
    <name>A0A835GMI2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMI2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="27980" checksum="F41F01295F344FDF" modified="2021-09-29" version="1" fragment="single">NNDHKNFINSVQNVRNTLGSLERSIGKSKQYEQRLLRCRGSHSHSHGVNDWWDSDHSEEKSFKSSSNSKTCQSNDDYTDTWSTMSIVCLQYQYEELAKRYQILVQAYEEQCNAVGLCDKRLGQWRERATSTQAHLTHAHKTLIAVGEKYIALKNKCNLKKNWYKEQLAAMKQSLHDMMEATTQARMEFDARLEYCMANERDSDAALLLYEIRRCNLLFLENMRLKAIIEELIPGAVNWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMK9</accession>
    <name>A0A835GMK9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003087</name>
        <name evidence="3" type="ORF">HW555_008692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMK9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="49474" checksum="F93AEE215F371B96" modified="2021-09-29" version="1" fragment="single">TTMEEILKVLQNIQNELAQQKQDIKSMEENIKEAINKNIDEKFNRFEAKTNQLEQKIEEQQKTIDYLDKKLRRKNIIFFGVPETENSYEDLIKSILDILNKTMKIECPKWEIETVARLGKNTGKVRPVVVTITTTSRKLEILKLKKSLENTGIYIKEDYSAAVLQKRKELQEELQRKRLSGEKVMLRYDKIVQIKPREKQTYKPKGAISNKRYLSESPEAVHFDKMSNNEEQSKQIPKKNKSQTITTKSNSDQSLFKPRLSRASKKLSNAPPSSPLPTRPVPVGDADQNPLEKTYYTDNNSEYNKLYIATYNVRTLLSYSRLLELSDALKDINYDVIGLSETRRFGNSIEEHEDFILYYMGQTPGLYGVGFILQPAKKSRISYGENTNSTLKNYKEIHAYKESLNGNLKHLIASQQSYTVQQIHDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMS3</accession>
    <name>A0A835GMS3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMS3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13879" checksum="F3DF3D2DB786B346" modified="2021-09-29" version="1" fragment="single">MPHLCSFGCKYTPGVVMHHFPNPDKFPERFKAWVNLVGGKLETSSDYRYYKKKMVCDIHFIDDHRNRYKRLNALAVPTLHLHGSSHTLQNNPATTVATENEPCPSLPTTGSSHTLQNIPSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN84</accession>
    <name>A0A835GN84_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN84"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="33749" checksum="47B52CD5257D0F01" modified="2021-09-29" version="1">MKAYKQKSVGVTFTPFRLGMTETLAPVSIKNDRREFLSVINRRYDVVVAPVPASSNAAVSFPGGGCCCSGSCMDVCIAEPPSRTCGGNNKYQILCGVECCHAVWGEDDIGSTHIGVFNPKSRSKVEYYKVLTKVMDGAEQGSAGTKVVTRNYVFRKSREYTEPDFGKKLDLLEFEIINDSSFPTDQKSKFIQTFSRLKSEMKSKWQTAKRTESVFLKKYHDWLQGTLEIPKKKINIEKSPGRPSKEFAELTDCTFSLGWVKNNVADFVEVLSFQVADDKLEHGLVALLLWRHYCFKLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GND9</accession>
    <name>A0A835GND9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GND9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="25070" checksum="0E750D63F810BD75" modified="2021-09-29" version="1">MQCFVFEVLSSYPQPTVQQYLQLMGLPQPHTIAVPAPHPAPASQPCPPSQPRPPPAPQTLAALALPNLVSRLQQMPPLPPPTNQPRPVSTPPPLTALGLPNLVGPKTESSCVDGKLLNNLAVALQLLIVSNILNSPPPKESLLAKAASENSPYAPSCSVPTLSNSNFIGGSNYPEQSLSKSYKPTRNGLALMSPYEALAPAKSYTDSYSFGSRQDFQSPYAALADQDLFSMNDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNF8</accession>
    <name>A0A835GNF8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein adenylyltransferase Fic</fullName>
            <ecNumber evidence="15">2.7.7.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">De-AMPylase Fic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HF086_016348</name>
        <name evidence="26" type="ORF">HW555_003400</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">BAW_Kor-Di-RS1</strain>
            <tissue evidence="26">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55932"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fic family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.108" evidence="15"/>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000240">
        <property type="protein sequence ID" value="KAH9641354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044603">
        <property type="term" value="F:protein adenylylhydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3290.10:FF:000001">
        <property type="entry name" value="adenosine monophosphate-protein transferase FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 23" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="23">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Fido" evidence="25">
        <location>
            <begin position="279"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="393"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="21">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="22">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF9420339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH9641354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="453" mass="51431" checksum="DEC64E38395391B9" modified="2021-09-29" version="1">MLFIGRPHEPENMKCGCKLKINTKMIVDRCKTVVILSSVVCTLAVVISLHKLLNHEAKFAKPFAPIPDGLYGNYLEPIPEESPSPPPRKPYDKTRDAEAVVSLNAALEMKKVGKDDKALKLFQHAFALSPKHADILNHYGEFLEDTKKDIVRADQLYTLALTNYPEHTGALENRQRTASIVENLDREMLRKIDEKRDALSSIPESNSALRRAKKEAYFQHIYHTVAIEGNTMTLQQTRSVLETRVAVSGKSIDEHNEILGLDAAMKYINSTLLYRLRAITMGDILEIHKRVLGHVDPIEGGQFRRTQVYVGGHIPPGPSEIQRLMIQFLEWLNSEDALDLHPVRYAALAHYKLVHIHPFIDGNGRTSRLLMNLLLMQAGYPPVIIAKQHRHLYYQHLQTANEGDVRPFVRFIAQCTERTLNLYLWATSEYSHMVPAIGEPHILTGEGFEEDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP30</accession>
    <name>A0A835GP30_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP30"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="205" mass="21557" checksum="6950E211637A28A2" modified="2021-09-29" version="1" fragment="single">ACLVRARSDSEGSSKHSFGTMTYTEDRLSGTEGGGGEPGNTSHMATSPPDHTTDVNESGELLDYNDSSVLEQFHEDALRQAGTGLAQARVTLAVFLAIAGASLELSAIPFILPSAEIELCILPHEKNWLIMISLVGGSLGAVGWGALSERLGRRRCLVSCLAVNAVFAAIAAFMPTYGTFMMARFCSSLGSGGIVPTSYTYCGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPE9</accession>
    <name>A0A835GPE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033096503" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="26"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="547" mass="61851" checksum="4DE2CCFB1529AFFC" modified="2021-09-29" version="1">MSVFSVKWLVLWSLWAARLVRQPTDTLQVSNGPVRGSISPDGTFKSYLAIPYATVPHRFQAPGPEPTWESTYEAVNENVRCTQSVEDSFTVGTADCLSLNVFTPIDASPDSNLPVMTFIHGGGYFKGSGNMIFYGPRYLVPKGVILVTINYRLNIQGFLCLRIKENPGNAAMKDQVAALRWVRRNIKKFGGDPDNVTIFGESAGAASVSFHLYSPMSKGLFHKAITQSGSALAAWAYQYKPVYLASLLAKVMLYESQDPHELYKFFMTKSDDELILTRVPRAEGNTVISEILYTPCAEIAIEGEEAFLTEPPFELLEKGAYNKVPVIIGTNNEEGLLIISMDNSTMIPRLEFEKSLPKNLEIPDKKTKQEVAAKLQKIYMEGDDISMDSIVKISRWYGEPNLNYPSLAETEMLLKSSDQPVYNYLFQYSGWRNIPKIFLPKQLKAADGATHADDIFYMFSHEIFASNFEMKMIDRVTTMWTNFAKYGDPTPEGSSLPIKWLRTNSSTPTSLVIDEEFHTAPLWYNNRIIYLRELYSKFRRKDTNILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPJ3</accession>
    <name>A0A835GPJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="416"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="909"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1381"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1783" mass="205390" checksum="3FFCA8DA45C68A71" modified="2021-09-29" version="1">MGRPTKRASRMRQRRLNETSEDHEKRLSQSRKTTAKAILNENSEKREKRLSQMRTYMKKVLDSENPKRRTYRLGLIQDRLSNETEEQRTHRLSLISDRLSNETQKQRAHRLGLIHDRLNNETEEQRTRRLGSMQDRLANETEEQRAHRFRLISDRLSNETEEQRAHRLSLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRFRLISDRLSNETEEQRAHRLSLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLRLISDRLSNETEEQRAHRLGLIHDRLSNETPEARLNRLNTMRQTSHIRRDITNEQSFQTAINVFADVSCDVCKKNIYPQQRFNLRPNMYNTLLPEELIALDKITTCSRCNNHIKKRKIPPTAYWNKMMPAEIPPELANLTSFEERFLCRIVPFLKIMKLNNRFSQNWCKGQVILFAKDVVEIADQLPLTPHQAGLILVYVIINDNKAILRGSFHQGDLRFNSSRGKQCTGIAAVACVAFTVLDPNNWSKSDIDYILIIGDKYYNDCIASRNNPAFGEMNPDYLAVTDLMPSLVYNRQNIAITVLEETNINGHLDNDNSSDGFPNLRNALRSFFTEYSSGILTTNAISVAVHYRTSYYYLFDSHARGAKGSSAPINGAACCMRFTDLDDLHTVLRRNLYVSPNKPSGGNLRDNLNVYSLTPLVVAVDNQMRSFRPISEQSAIEMMESPTFTPSPINLLQPPIQVIESVQKTLQSALAQGSEIQLPITANNSLNTIYIESTSMLQNIDDNVPNLENVVGVNTSLTDDTMRLAAITRKTAPPLNLERERRMEELCWYFIYPDGKNGFGEERENPVTPLDYFQNRIMSNERRFNRNEYLFYALSIVEYFRAKSIQRHPVVVARQFTLRVNALMQFLKRNQVCLGGPIEDFWYRVEFQNRGSPHLHMLVCSVPEFSTPQGIAVVENVVSCSLNPDDPVLRKLVEDLQIHKHTATCKKNRQDDGCRFGFPKPESDNTVCLGPDEALANNGRFCLLKRTPEESMVNNYNAVLLGIWKGNIDVQPCGSVTAVAYYVAKYASKCEPHDTGDVIREAISKAKRQGGDVWKQLFSVSMAILNQRLVSAVECAYRLCHLPLKMSSRKTVFVNNCKPEERFRLLRFDSDETSIYNNIFDRYMLRPNQLEDLSLAEFAVRYETVSSTIWSEDDGDAELREEDNITTVRYIKLLDNTRMRVRNRPAVLRTRYYTINSDKEAYYYSLIVCHIPFRNENELLLENESAEDCFVRRQRDLRPLLGNISAEQFAHAEQIIQQALAQVTALNAARETHVNNAPVLCAGEQIVNRDETFCEDMGERALMSDELFLSSIRGLNIQQRNLFQKVSLAIENDLHGQESQLLLFITGGAGSGKSFLLKLIVEHIKRCYAPTVDTLLKPNFVEVGSLTGVAARQIFGKTLHSIFLLPIEKGNTMSYKKITGQRLENERRKWRYINWLIIDEISMVSYENLRIIHLRLQEYKNNEKLFGGVNILLFGDIFQLPPVKGHWCFLQPSWFSAEINLWFFIFSFCELTINMRQRDDTEFIELLNSLRVGELTTAQLELLCERRHVPLNGEFANGVAVRIFPTVRQVDDYNDKMSTENAKLHRTYQINAVDESREVATYGRKPPDNVIPKDVNNCGGFLCSIKIGVGSRVMLRRNIAVSEGLVNGAMGIIKKIKWPALRRDQLEEGELPEAVYIKFDDDTIAVRLKDRDGCIPIPPSSTTFQAKRVFDGLDETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPK5</accession>
    <name>A0A835GPK5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_001726</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9422732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="33343" checksum="0A866371D7A758E5" modified="2021-09-29" version="1">MSVKVEKATEPLLLGEGPHWDEHHQALFFVNIQEHTIHKYVPATGAHTKTKVGGRVGFIVPVEGTTDQFLVGVDRKFQVIRWDGADGSPATVVKELVEVDSDIPTNRINDGKADPKGRVFAGTMGHEDPPGNFTMNRGNLFRLEGGKVTKVVSQVSISNGLAWDLREKAMYYTDSLEKNIRRYDYDVETGEISNVKYIFDFEKNKIEGFPDGTTIDTDGNLWVAVFDGSCVLKINPRSGELLQKVPIPALQVTSVTFGGPNYDILFVTTASLNIRGPQDPPCGSIFMVTGLGVKGFPNVNFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPX7</accession>
    <name>A0A835GPX7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HF086_018454</name>
        <name evidence="15" type="ORF">HW555_001519</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000818">
        <property type="protein sequence ID" value="KAH9630538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF394">
        <property type="entry name" value="LUCIFERIN 4-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0455">Luminescence</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="13">
        <location>
            <begin position="78"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="14">
        <location>
            <begin position="502"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9422976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9630538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="592" mass="65515" checksum="CB885621D9960BD3" modified="2021-09-29" version="1">MSNLKVLRGSLARQILNSFVSGKHGKKSNRELLSYSRLLSRSLATQTATAVDNKFLTSPWGEIQVGQETLTDFVFSDVESWADSPSVTCGASGRSYDYGMMRMMIERCACALAGPLKLGPGERLGLILPNIPEFVVLIHGAMRAGLVVTFANPLYTADEVTRQFRDCNVKAIATIELFMPVAKEVSKNLKDYKGTIWVGGEDDKGQGIYGLKSLLMADHQADLPTVNPDEVCLIPYSSGTTGMPKGVMLTHKNLVSNLKQTQCPKMMKYEGEKGKGDVLLTVPPFFHIYGFNGILNYNLKLGYHVVTMPRFTPEDYIKCLVEYQPTTLFVVPSLLAFLATHPSVKKEHLQWVETIMVGAAPTTDSMLEKFLLKCEKTKDQIKLLQGYGMTESSPVTLMTPYSYPYSKVGSVGQLVPSTQARVVSLTTGEMLGPHKSGELWLRGPQVMKGYWNNEAATKETVDSDGWLHTGDVAYYDDDFYFYIVDRTKELIKVKGNQVSPTELENIIMELPAVADVAVVGVPDPLAGEVPKAFVVLKPKQKLTEKDITDLVAKKLTRYKHLDGGVVFLESIPRNAAGKIMRNELKVLGMKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPX9</accession>
    <name>A0A835GPX9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPX9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22753">
        <property type="entry name" value="OTU_ALG13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20380">
        <property type="entry name" value="Tudor_TDRD13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049769">
        <property type="entry name" value="OTU_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049770">
        <property type="entry name" value="OTU_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="752" mass="84921" checksum="6601D5057F80DC8D" modified="2021-09-29" version="1">MSPSPIRCRGPWKIHKRSSEPDRWLDEMGFFRKHTARDSSCLFRAVSENIYNTQRYFHKVRLDCVQFMASKRHLFEGSLTCPFENYLKEMSNPSEWGGLIEISAMSHLYRRDFVIFEANKGPQTKICNGYGDPIYLFYSPDTKHFDVVYTKDFITTSSFCQSLVYEILYDGVYQLKDLSYAVDKMLHDKVPSNHIEYFMSENVERRKKQKERAKIFIEAADDDKDRSNNALALKCKHHTEDLERASLLKESLSIFVFNRSLIQLENVCMNCLNVNSAKDLLDNGITPFPYKVAKALDPDIYRNIEFDVWSELRREMRYGARYSDGTTLQVGVKCLCKLQPEQTVPYHCHIQEMRPDGGPCLVFIEELGEKRIVNFEQLEPLPLEEIRPWAPPYRYSRAHSQFLTLSQMLQQIGNITLKQGLSKARNKSKGAPDDKTPEKVSKPSKVSWNEETGLAFQNNVDFTYQHLDFLNFEPMPVEVEALPLMVDCRPGAGAPPLELTHPQPNGGAPNENHHNQAGGNGDMVAHGIASPASVRSSTPASTNTLTTYTNAMNPGGGVGGNGYPVGGVGGMPGPNGSDLPMNDIPTLRFYYNLGVECVWATYGPPRPYSARDLAHDLAHWDVTCHFRFNRFKRGGGNQDGNQNSNHNQNKHNNNMGNKGPNNRRNSHGEPRGPHIGYSGAGEGECVMEQPMLTLPYIPYPPPMYPIQYYPVETDPAMMGMMGGMGYVGYEEGATPATTSSIIHHHSKDHHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPY0</accession>
    <name>A0A835GPY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_003085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9420737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="385" mass="43750" checksum="76067E06B96EE0A3" modified="2021-09-29" version="1" fragment="single">VYYAKKKRRAQQYLGEDGSHKKERKLYNDGYDDDNHDYIIKQGEKFLDRYEISSPIGKGSFGQVVKAYDHEEQCQVAIKIIKNKKPFLNQAQIEVKLLKMMNRADPENKYYIELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGVPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGMPPDHLLDQAHKTRKFFDKLPASEGGGYVLKKVNGKDGSVCSGVNVCSGYRKYRLPGTRRLHDILGVEGGGPAARRRGEPGHSVSDYLKFKDLILRMLEYDPKQRVTPYYALQHNFFKRTADESTNTQQAQSHHQHGARAWGGGAERMEVEGARRSPDLLAPVCPLPHSPVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ26</accession>
    <name>A0A835GQ26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_005174</name>
        <name evidence="11" type="ORF">HW555_001600</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000168">
        <property type="protein sequence ID" value="KAH9642892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ26"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF103">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9642892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="352" mass="40919" checksum="95D144275B1E278F" modified="2021-09-29" version="1">MSYLEKVDRYLDSLKVGKSALVDSWFMMSSPMPLFSVVVAYLILIRIGPRIMKNRQPLQMNRLIAYYNASQVLLAIVICFKVFKLNLFRDGIIYAGCRYPSNTQNVALLDLGWWYFFAKFTELLDTVFFVLRKKDSQVTFLHVYHHVIMALYSWSYLKFAAGGEGAVLALLNSIVHVVMYSYYLLSGLGPRFQKYLWWKKYVTKLQLIQFILMLTYCAWTHFSPRCQYASGFTYFICTNITIFLFLFLNFYSKSYKKRNLEKKNIEKELKEEYNKTHSNTNTNGVCKNGVNNKKENGVHGNDCKGVPNIEEIPCEVNKACGDYVKDGKFFLSRRTAKAAFGAEYDFDSIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR29</accession>
    <name>A0A835GR29_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR29"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29283" checksum="EAA059789CB35CE4" modified="2021-09-29" version="1">MFEVRDKVFFVTGAAAGIGAGIVKAFLEEGAKHVAALDVDINNGNALEKELRERYGNDKIKFYKCDVTSGELDAVYDKVLSDFEYIDVVINCAGIMNDRPNAYLKEIDINVTALIRSSFKAFDLMREDQGGKGGTIINISSIVGLFQAHLLPVYTATKSAVLQFSNCLGKEPHYTRSGVRVLTICFGCTDTSLFSASKMGGFDKATDELLFKSLGGLPMQTIQSAVDGLVHAYKHGASASTWLITSDRPAEDVTNNVSKGYEVMSQGVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRG8</accession>
    <name>A0A835GRG8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRG8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54572" checksum="663BF20B25E9F10C" modified="2021-09-29" version="1">MENAEEIFHFLEDFSKRKPKTIPQELNEYLAYVARTGDPVYQWSLVKSLFKEKLLSVITDFYETTPGIDIPPYPNVDPFNYDIMKNSLLERLDSFTSAPFTVQRICELLTFPRKQYNRVDKFMRAIEKNILVVSTREPGIQRHAEPENGEPVEPIVNGSDNNSEYNVDVEMEDMSWKENAEQPQSSEPQPGSSDAQISVDDIEARLKAKQETPMDTQDKITTQYESVTPPELNITADEATEETKPCAETAPPSTVSTEESKMETTTSESASEEAKVDVEMKPENAAPALVIPEIKVDDAEMTEQRLTEQTSPEKVVSTEPSDKEASASEIKPVADPQPVSIDENSSDSTTKEDSEPKLISEVSTSSEESSSSSDNTDGNSNSPKANERHIDVQEESNQSDTPSDTASEESNAKENEPTPETTPERPAEESSPKVEMQSDNYSISDVNSELPQPPQENPKSPEVPEEKKEPEKIEEVKSESTETEQNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRZ5</accession>
    <name>A0A835GRZ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="4" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032736046" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1918"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="342"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="649"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="961"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1227"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1516"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1987"/>
            <end position="2222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2222" mass="234232" checksum="E07CD590017AE726" modified="2021-09-29" version="1">MKLVYFLALVAFGSARHISLEDVIEFERNSAYGYIEKIGKPYADKVRIEEEAALNNPSRIIGGSHAVLGQFPYQVGLITEYPRGNSIASAVLISSRRVLTAAHNINDAVVSVTRINVVLGSITIFTGGTRLVSTSFVLHDNWTPPVRNDIAIINLPWTVSSSNILAPIALPSGAQLNENFVGDIAIASGYGLTSETGGIPANQRLSFVHLPVISNNECIQTLGPTIQSSNLCTSGAGIRGICTGDSGGPLAVTRNNRPVLIGIASFGSLRGCEAGLPSGFARFLAGILLALAVAASARHITLEDVIDLEKNTQYGYISAISLPLADKVRIAESEGRQNPSRIIGGSFAAPGDLPYQAGLVVHLPFGNGIASAALISNNRVITAAHNLNDGVSNALSVTVVLGTTTLLGNGVRFTTSDFVLHENFNIFRLISDIAIINLPSSVEFSNVLAPIALPSGSQLEEDFAGDIAIVSGFGINPILGGVGVISDQPVSYVDLPVISNNECAQLYGNIVQPGVVCTGSVKGKNICTGDSGGPLAVQRNDKPLLIGIVSFGTPGCSGGSYSGYSRVSHYIDWINKLLHDHRTSSFKLTVNSKMQSSVVILLALAVAASGRHITLEDVIELENNTPYDYIKSLQEVFIEEKSEKNPSRIIGGSFAALGQFPYQAGLLIHLPFGTSIASAILISNNKILTAAHNLNDGVSNVPSVTVVLGTNTLMGDGIRQTTSDFVLHENYDISIFRSDIAIINLPSKVEFSRNLAPIALPSGSQLEEDFAGEVGIASGFGNNPSIGGTHANQPLSFVDLPVMSNNDCAKIYGSFIQPGVVCTVGVVGKNICSGDSGGPLAVERNENPLLIGVVSFGPRLCGDHGPAGYSRVSHYIEWINELYKPECLMINHTTYVSSNMKFLPGILLALAVAASARHITLEDVIELEKNTPYGYITAISLSLADEVRIAEAEGRQSPSRIVGGSLAALGQFPYQAGLVLHHPIGDGVASAALISNNRILTAAHNLNDGRSTVPSVTVVLGTTTLMSGGVRQTTSNYVLHENYDISLLRSDIAIINLPSPVAFSSFIAPIALPSGSQLVEDFAGDVAIASGFGINPAIGGVLPNQPFSYVYLPVISNDECALYFPTVVQPGIVCTGSVVGKNICTGDSGGPLAVQRNNNPLLIGVVSFGRGECDGGSPSGYARVTHYVDWINEQKNTPYGYITAISLSLADEVRIAEAEGRQNPSRIVGGSLAALGQFPYQAGLVLHHPIGDGVASAALISNNRILTAAHNLNDGRSIVPSVTVVLGTTTLMSGGVRQTTSNYVLHENYDISLLRSDIAIINLPSPVAFSSFIAPIALPSGSQLVEDFAGDVAIASGFGINPAIGGVLPNQPFSYVYLPVISNDECALYFPTVVQPGIVCTGSVVGKNICTGDSGGPLAVQRNNNPLLIGVVSFGRGECDGGSPSGYARVTHYVDWINELTLLALAVAATARHITLEDVIELEKITPYGYITAISLPLADEVRIAEEEGRPSSSRIVGGSLADLGQFPYQAGLILHHPSRSGLASASLISNNRILTAAHNLNDGFSNVLSVTVVLGTTTLMSGGVRQTTSDYILHENYDISVVRSDIAIINLPSPVEFSNTVAPIALPSGSQLEEDFVGEVAIASGFGMNPGIGGVLPNQPFSYVDLPVITNDECAVTFGTYIQPGIICTGSVVGKNICSGDSGGPLALQRNGNPFLIGVVSFGRGGCDGGSPSGYARVTHYIDWINERLRNMKFSGAILLALAVSSSGRHITLEDVIDFEDNPAFGYHTKIGIPLADKIRKLEEENPSRIISGSLDMAGLIFRLPIGTSIAGGVLISQRRVLTAAHNLNDAVSSATTLTVVLGTINIFIAGIRIDTEEFTLHENYNAATLRNDIARQSVLPIYPQNQWKKKILMARLLSFLVMDIPLVFLALALFALAAVATAKNIHFEDAIDLEDISAYGYLSKIGKPLADEIREAEEKASASRIVGGSHSELGQFPYQAGLLADFWIGQGVCGGSLISANRVLTAAHCWFDGIDQAYRFTVVLGSVRLFSGGQRFTSSNVIMHWGWNPNLIRNDIAVIRLGSDVSFSDIIAPIAIPSGDLINESFDGEVAVASGFGRTGDNVGVSVNQVLSHVELSVISNAICRASFPLYIQDSNICTSGANGKSTCRGDSGGPLVVNVDDSPVLIGITSFGSARGCEVGAPAAFARVSSYVSWINDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSE7</accession>
    <name>A0A835GSE7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="198" mass="21803" checksum="84CA59D665058CAF" modified="2021-09-29" version="1">MGSGASGLASETPGGDLRLPASGLRFSLNQLRTLNSYVDNLWEEDQAGRISTELESAVESLVQRIVDGAGQRDPRFRCCHLIALHRGKKMRSRSLEYLVTLDSLPPLNAGEDCSLQNGPVGYGRIRLTGKEADKWEEFLTPSGYLCRDKVVERWVELIARCTSARGGGGSRVLCARAVKHAAPYTHCYLQRVLDLVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT11</accession>
    <name>A0A835GT11_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">39S ribosomal protein L13, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_011312</name>
        <name evidence="4" type="ORF">HW555_000235</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000027">
        <property type="protein sequence ID" value="KAH9645522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT11"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L13, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9645522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="21002" checksum="FF9D2BCA2067E693" modified="2021-09-29" version="1">MSAAKRVQQWATFARTWHIFDCKWQDPYESANIIKKYLMGLHKPIYHPMNDCGDVVVCINSREIALKGDEWRKRAYFHHTGYPGGASWTLAWEVHNKDPTMIIKKAVYRAMKGNLQRRHTMERLFIYPGEAVPEDVLQNVTNQIRQNRLVPTRLDHIPEEVTKSYPKVMDYPQDYILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GW87</accession>
    <name>A0A835GW87_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Syntaxin-18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_000330</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GW87"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15850">
        <property type="entry name" value="SNARE_syntaxin18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000015">
        <property type="entry name" value="Syntaxin-18, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9424519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="37803" checksum="EF022039072386D8" modified="2021-09-29" version="1">MDITPLFRAYIKTVKTRNKAFGIQSPTSDDKQRILRTKPKTAFMITAKDITSQITRLRDFLLEHREKYLSFYDNVVAEEMTDAERDQIDTGAQRIINTCSHLLKEFRNDNRKVTAAPQMKEYMEAVADLIDMYLKAVCKIHSELKALRVKRTLVMRKLSRLELPQTKSNIPNPFIVGKVAEKDTDKVLDKDIEEVEEPDTVKKMDLCENDVAVLADEELSAEELQMFESENVQLLNELNSMTEEVKAIESKVLHIAELQEIFTEKVLQQEQDIDRISNTVVGSTENVKDANEQIKQAIQRNAGLRVYVLFFLLVMSFSLLFLDWYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXR4</accession>
    <name>A0A835KXR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000752">
        <property type="protein sequence ID" value="KAF9405369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.620:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.620">
        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="10044" checksum="D291E236D265B657" modified="2021-09-29" version="1">MASQTQGIQQLLAAEKRAAEKVSEARKRKAKRLKQAKEEAQDEVEKYRQERERQFKEFEAKVIRDILNLVYDIKPELHTNYRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYR4</accession>
    <name>A0A835KYR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000630">
        <property type="protein sequence ID" value="KAF9406177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="479"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="663" mass="74272" checksum="B6EFA573CF3FFCEF" modified="2021-09-29" version="1">MGALSLYSLHFATIRKLCGIVLKFSKKIKIRYSEMPADYDTIIIGMGAAGCTAASTLSKAGKKVLALEAMDRIGGRVNTVPFGDGVVEIGAEIHGTEQSRVYNLAIQNNVSVVPQDIDFEVYRSDGTIGDKEVLNELLNFSLGVVDDPPATPEPLGQYITKRLKEYMRAKYPTLLADQDFMDNLLEFLDLVVDNYESSNSWNEVSTESKYTELGGHQHMSWHRHGYKTLFEILLNTYNNGPGYPNLDIKLKKEVTQISWSKDPSQDVVVTCKDGSSYRAKNAIVTVSLGVLKERHARLFVPSLPTEKDIAIDKMSIGVVLKIILQFEYNWFSNIPSFAYIWRDVDKKDVSAQDDWMFSVGESSSPMGCTEKMRRGHARLFSPALPQEKVTSMQKISMGVVGKVIFLFENRWFTVNVSSFSFLWRTEDRESLGNDEVWWLNICAASSSMGNPVSLTLWTVGEMAKLASIDVFTESTERENRSIGVVDKVVFLFPKPWWPDSETFHAFVWTGADRATVPKEDNWLTKIFGVSTPLGSSTALTMWTSGEGAKLVETLPEDVVKRKAMELLRRFMGKNRTIPEPIAMLRSSWYSNPYTRGSYTFDNLSTPQYPHARATLAEPLVDSSGTPRVLFAGEATDNTHFSTVHGATDTGFREANRLLTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZM9</accession>
    <name>A0A835KZM9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000451">
        <property type="protein sequence ID" value="KAF9407627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1901"/>
            <end position="1934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="3538" mass="408018" checksum="1BF9745D1A1A6FB7" modified="2021-09-29" version="1">MAPCSPVTLSGDTLGQRHRHLNSLVRAAKESGTTVQDVEAVPEQSPTDRLFKIDLAVSLRDTDYIIQNLKHDDMLFVSRALKARWLLDRHDVINPKYLEETLFPEMISPAVTKMRHWLYINLREPPKCLEFYEYYKQNSFEFAIKFLSRCNSHFILEEVPKILTKLSPHYLKVLCERCPTVAKIYFDALATQDDLKSRYLEQEQSYYNSIKCVLKSDADVFLDITEEYFSLNNFKRFSPLATDYIVRNHKSRVMNKLGLYVAHILHIPTLAARLSVDECQDVVMQLARAKYLQHWFQYKPVEPLIKRLHPQKRAAFKKMIFVVKDIGECIQDWPYPTPKSPPQVDTSSHVFDDKNYAPFTHQQFSCKRMLKKKKCGRFMAYDIMTVEDSNMKTDLQRLFEEFRFIGFDRALHDLGQRLRSTGSADRRRDIFLVLVSKTGGRNDAVSALLRLAVRHSNEPVHIRAAVVRSLVKRAAVWRLPADIWKHLLDFGRGIGLDGAPPEATCFEGLHAVVIRQLLAGDCEPTIINTFLNNFSTLKEYSLKVEERLRIAVGLQNLLVAAVDMEPDRSAHRICQLLDVIEAYGIHVQTISPVIEIIKSLTQTDKDVVRPLLERLYQAKIGRQELLRENLTLRCDEAALLNALRHDLSALEMQHIIDVIAQGGTKFDRFISKLVVYFNQNEKLPIYIRTALQEKIALEDKNKGEIIQQVRPLVSLLYKDFENMLYGLDATETKNNTFKAALRACAHRARPVVNLAEWGWKRAGVKAVATRVMRCREVERAEFIRTLAAERRTVRVALALSLRSEGGPVLDTFASAAKLRPVVALRVALHYFRHYDTNADLDVWKIIKPLLFEVDLSSKKRLHNLLKRTRRIPSAIKPDYCATLYLVSDKTPERGSEDLLRELCMLLPEVEIDTIETILTGLFENTGEDVVPLPYPAMIVRYLMLSENSEDLEKRFTKIGNRFLECLSSLSCDNNSVFKKRLKQTIGSLKYNAAFLDCKYSFCFSVIEKILNWLQTLLPKEKNFRKYVKIHLTMLYFKAVRQSIKQMPEVFADPKRKRTEGVEAVGFVFGRYIVKEVAELVTTYFDSIIELYTGALVNYLRDFADGSSKSMFIESTLKGMLAGAVGTERRMAVYVLKDRSYDVENATRKELENLMIQDKYLETEHETDGRSVRSPEEEEEAVGFVFGRYIVKEMAPHSPVTLLGDTLGQRHRHLNSLVRAAKESGTTVQDVEAVPEQSPADRLFKIDLAVSLRDTDYIIQNLKHDDMLFVSRALKARWLLDRHDAINPKYLEETLFPEMISPAVTKMRHWLYINLREPPKCLEFYEYYKQNSFEFAIKFLSHCNSHFILEEVPKILTKLSPHYLKVLCERCPTVAKIYFDALATQDDLKSRYLEQEQSYYNSIKCVLKSDADVFLNITEKYFSLNNFKRFSPLATDYIVRNHKSRVMNKLGLYVAHILHIPTLAARLSVDECQDVVLQLARATYLQHWFQYKPVEPLIKRLHPQKRAAFKKRVFVDKDVGELIKNWPYKIPTSPMRPDLSGPHIFDDQDFVPDIIFEPYFPLGGACAPMAAGMASLACVRMDCYQPNNFFTKIRTDLDRLFDEFRFIGFDRAVHELSQRLVATASPDRRRDIFLVLVSKTGGRTDAVKVFMQLALRHGNEPAHTRASVIRSLVKRAAVWRLPADVWQLFLDYGHGLGLDGTTPEAACREGLHAVVIRQLLVGHCEPAICDAFSKDFSTLTEYSLQPDEKVRIATNLQNMLASTAVNVEPEVTAQRLSQLLDVLNAFRIRIEASSLVVNSVLGLAGQDQNVARPLLERLYNAKIARRELLRLSMTFRRDEAALLNALRHDPLALDVAQVVNIMYERHTKFDNFTAKLVVYFGQKQDFTTQLKNALKERILKQTEEDSSTAGNIRPLKAFPPSSLRREPTNNDMPNRFQYPIFPPRFPLRPRQPRIPIFRGQKIKLIRPLASLIYQELEKELKELDQAGSDYTKMAAEMRACGHRARPIVNLAEWGWSRAGVKAVATRVMRCREVERAEFIRTLAAERRTVRVALALSLRSERGPVLDIFTSFAQLRPAAALRAALHYFRRRGSSAELGVWNIIKPLLSTVDLMRRERLRRLLENIQWIPSPIKPDYCINVYLVINKISRILPQADESIDKVLLDILDSADRITPAVFIRYLMLSVDDEDLEKRLLKVGNRFLEYLNTLHREKNVDFPRRLNQVLVSLQYNAAFFDTKYSCCMKVFEVILDWVHTFTTKERDFKIHAQVNLLMLYYKAIRQCMQQLPEVFADAKRKRTEGVEAVGLVFGRYIMMEVVKLVTTYFDSMIELYSRIVNNFMDYFTNCASRSIFIKSTLKGMWEEGVGIQRRMVVYLYRDRGCFEFDNSIKKEIEELLTQEKAVECFMAPHLPVTLLGDTLGQRHRHLNSLVHAARESGTTVQDVEAVPEQSPADRLFKIDLAVSLRDTDYIIQNLKHDDMLFVSRALKARWLLDRHDVINPKYLEETLFPEMISPAVTKMRHWLYINLREPARCLEFYEYYKQNSFEFAIKFLSHCNSHVILEEVPKILTKLSPHYLKVLCERCPTVAKIYFDALATHDDLKSRYLEQEQSYYNSIKCVLKSDADVFLDITEEYFSFNNFKRFSPLATDYIVRNHKSRVMNKLGLYVAHILHIPTLAARLSVDECQDVVLQLARATYLQHWFQYKAVEPLIKRLHPQKRAAFKKRVFVDKDVGELVENWPYQTPSSPTDIDTDPHVFDDTEFEFASFEGARCGFGMSLKCANVSYAQCRMLCDDEYDECMMAKVKTDLDRLFDEFRFIGFDHALQDLSHRVGTTGSTDRRRDIFLVLVSKTGGRIEAVTAVLQLAVKHSNEPAHTRASVIRSLVKRAAVWRLPADVWQLLLDFGHGLGLDGSTPEAPCREGLHAVVIRQLLAAAVGAEPTVAADRLSKLLDVLKVYRIRVEASSLAVKTITALAQQDKEIARPLLERLYDAKIARRELLRLNLMFRRDEQALLNALRHDPFALEVTQVIDILTDRKSNFDIFTAKLVVYFYQKQDFTTKLRNALKEKISKPVDKKSAHFKLVRPLASILCQELVNELKKLDQTGAENVKLKAELRACAHHARPSANIAEWGWKRAGVKAVATRVMRCREVERAEFIRTLAAERRTVRVALALSLRSERGPVLDTFTSFAKLRPAAALRAALKYFRRRGSSAELGVWNIIKPLLSTVDLTHRERLRRLLANTDWIPNPIKPAYITELYSAVHKISRSNANDLLHDICKILPECDESVENILLQMLDNMDAGNPAMPYPAIYIRYLMLSKNNEDLERRFSKIGIRFIEQVDILRSKKDDKFTTCLDQILESLRYNAAFFDTTKESCLLVIQKILDWLQKFMPKEKFFKNYVYIHLTMLYFKAVRQSMKQMPEVFADPKRKRTEGVEAVGFVFGRYIVKEVAELVTTYFDSIIELYTEALVDYFESTLRYGASRQKFIGYILKGVLADGVGIQRRLAVYTFRNCRYSVDSEMVKEIEEQMSKDKAIEIFVHAEIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZZ5</accession>
    <name>A0A835KZZ5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_000829</name>
        <name evidence="4" type="ORF">HW555_011442</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000340">
        <property type="protein sequence ID" value="KAF9409095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000572">
        <property type="protein sequence ID" value="KAH9635108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZZ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9409095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9635108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="216" mass="24218" checksum="78680C1C316B7313" modified="2021-09-29" version="1">MPIDLYYVPGSAPCRAVLLTAKALNLNLNLKLVDLHHGEHLKPEYIKLNPQHTVPTLVDDGFSIWESRAIITYLVNKYGKGSSLYPEEPKARALVDQRLYFDIGTLYQRFADYFYPQVFGGAPADKDKLAKIEDALQLLNTFLEGQKFCAGPTLTLADLSLVASVSSFEASDVDFKKYPNIKRWYETVKTSAPGYLEANEKGLDAFKGLVNSMMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L019</accession>
    <name>A0A835L019_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000330">
        <property type="protein sequence ID" value="KAF9409207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L019"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF309">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="458" mass="50530" checksum="18933EC352CF8219" modified="2021-09-29" version="1">MKMLGFGSSNAFGILFHNFFLEQGSASGLPLVIGVYNGALSIAGFLGGIALKRYSFRQVGLVGAGLFVLGDVLTIFVQKTYQLVFTFGVVRGAGFGMMIPVSFTAFNCYFTKKRTAMMSANQAMSSLASITFPMLVTFLLSEYGLRWTLALIMAVDLHLVFAMLVMHPVEWHMIKSEEYVEKELSDISSIKKENYDEFAVRMLPAGEGEAEVRPIKKRKKESMKMNIVKIICENVEMDLLKDPKFVSTLVGLGFAFVSDVTYLAMEPMLLFSYGFSKMQVATCVMVGAISDLFARLVLAVVTYFIVVDSRLIFFIGTCITVFLRIGLVATSSLWVVFGITAVSGLVRCSVQVLFPLVLVGAAPDRFPAALALHILFSGTLMMLADPMIGVLYEATGSYVYCFFAMSFCCLVCVMLWSIEYLVYRKGSTNSGRPIGVTEDLVQFIVNFGLYILVKTQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1B7</accession>
    <name>A0A835L1B7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000180">
        <property type="protein sequence ID" value="KAF9412710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53163" checksum="9194DCCDE36DFF6E" modified="2021-09-29" version="1">MKKRLGGDDLQCAEANNITKDEIEDWVEQYRDKVNCCQMVSKFYGGQKHVLFNYGKSSFIAFSYLLVMMTPLWAGQVLNGQGIKFRQMLVRLYNTITIEKAEAEGKLIKDFIRLVKKNPIQMQLVYGVPVGMGLLPITLSLFINYLMLEGPKINQSNYIYCLFASFSYVAGLMTYIMVIYYSSAFKSYIDSVNFAMKFFENDQNLIRCLKRILWFALILIFLSTAFAVVRVVEAMLVMSHSDMLVMLPSVVSQAVKMQASDYYQKSIVVSGHLTVVMMPLVAGRLVTNHGLKIHRILARLLNTLDTDSNRNETKLVKDFIRLIKKNRLQINLLSNVTSGLTALPIIIMFFINYLIVLLQFNHVLRLFLIFTIYVSVIVVPLIAGQMVTNQRWSLLRVVARLYNTMQDSNETEVKAVKDFIRLMKKYPLEIKLFSKISSGTSLLPAVLMLAVNYFIVLLQFNHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1S6</accession>
    <name>A0A835L1S6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
            <ecNumber evidence="5">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000212">
        <property type="protein sequence ID" value="KAF9411799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1S6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="354" mass="41387" checksum="5660D9E399870A52" modified="2021-09-29" version="1">MSSVCLAAGDIFVPIKIDENDLYAGVLKLLKTIRPNWIQEKIKLKTLTDGITNKLVSCQFLKSSGEKEILLVRIYGNKTDLFIDRSAEIRNIKTLNVLGLAPQIYGIFENGLAYQYYPGITLDTESVTNDNIWPLVATQMAKMHKVQLGKEIPKEPFVWDKIEQFLNLLPDPFTSEEKQARFTNSFSSITKLRIEYERLKTLLSKTESPIVFAHNDLLLGNVIYNKDEGTISFIDYEYAAYCYQAFDIANHFNEFVGLSIDDIDYDRYPCEEFQFEWIKVYLAMYLDVDHPTEPQIRKVYKEVQQMSLLSHFLWGIWSLVQYEHSNIDFDFGRYAEIRLNRYYELRDKIFKQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L276</accession>
    <name>A0A835L276_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000287">
        <property type="protein sequence ID" value="KAF9409956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L276"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003902">
        <property type="entry name" value="Tscrpt_reg_GCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50807">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="210"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="319"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48125" checksum="91DEB63160081BB7" modified="2021-09-29" version="1">MELPSKPVIFDEYGKEISGTAGPYHEGGEFKLICSVKGGYPTPRIQWLQGDTVLATLSAGEYSPPTRSLTLVIRNATRAHLAALYTCTADNTLLAAPQKTTVKIDLFLKPLGVEIISREQPLSVGRKSELWCKTMGARPPATITWWLGGKKLEAITKDSGVADANETESLLQWMPSKDNNGQVLTCRAEHPNFNHSSIESKLQLNVYYMPEAKIHLGAKMNPNDIEEGDDVYFGCKVDANPPAYKVVWEHNGVLLQHNPANGVILTGNTNLALRNVSRLQAGRYTCTASNVEGDGKSPYLHMQVVYRPLCQRKEMKIIGAALQEPTTVTCEVDAFPPPDTFEWTLNNSAGSIKVDPDRFTVEGKEGKSLLTYTPVSDVDYGTLSCRATNLAGQQVTPCVYTLLPATRPDPPTNCTVYNLTHDSMDLMCLPVVQYFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2E1</accession>
    <name>A0A835L2E1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000272">
        <property type="protein sequence ID" value="KAF9410232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53252" checksum="FF70E0A89216DCD4" modified="2021-09-29" version="1">MTETDSTKRPLQMPEKFLPYLEKYRVYLMMKDMVRNIIIYLPKDHIKQMKIFANRHIHTSEASRMILLVEPGLNIDVHGLVKRLIKDFGCFVITRRCVMDRYEKSLSLMLITDFTSLTQHDEYEPGCVNIALMSEVTKALTLKEPVPQAGWVMFDHPCTLREARYLQQDGVLPTVTLVLMATPPTAPPAACNHTPPRNFFQQDFEGLKYAYKATLKEVHINPGDDLDEIQTKCFNAIRAFNAGHQGPKQGICAVGAPSVYRVLLLGPRGSGRSSQALALAKHFGLVFLHFDALFREYAAKDNEIGERIRKYGTSISLRGDIIRDRLLKKDCIDHGWVMIGYPTNGTDFEILDKMPTPPNRLVFLNVDLETCRRRTQNEGFDICTGKKAPMGSGPNVVRHPDHDEVRREYEWDLFFTEQLAELRASAGLTAVEIDGCESFDKVQAKVQAAVISAPHFDIECCSQLRNVCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2N0</accession>
    <name>A0A835L2N0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2N0"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13336" checksum="835E309D043F9528" modified="2021-09-29" version="1">MNNLVSRVAAKQCLSLRAVARVSSRSFVSKIEDASTHTGQKWESDDYRLARFMNAPKQVNPNWAVNLIAEVPPKQVTERVVWCDGGSGPEGHPRVFINLDKPGDHSCGYCGLRFVKKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L396</accession>
    <name>A0A835L396_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000222">
        <property type="protein sequence ID" value="KAF9411516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L396"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="84"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="538"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="84666" checksum="4580DD2ECFB7B61B" modified="2021-09-29" version="1">MFSLDSSLQQNCCYEKKQEDEITKRTVRCSSVLIGALGISLIALAIYTAVLVLTEYRSPRPCLSEQCVGTASRILQALNKDVDPCTDFYEFACGGWIKQNPVPDWATSWDQLAKLREQLVTDLRDLLEAKDDEGLPQSVKKAKSLYRTCVNTERLEDEGIKPIQRILQKLGLPPRPPTEMTANFTWETVAGRGRRNLGLNVLLSVQVAEDVRNTSRNRVVIEQVSPGFSDRYLLQPEQFSHELSQYHKYIKSMISIADNETDAEQFADDIVDFSKKLAKIMTPVEVRRSGTHLFHEVSVQQLIQGSSGGPVQWKQHDWELYLKLVFSNTSVVLHPHQDRVIVMDLPYLQKLSVLLADTKPVIVERFLWWSVFSTVAPMTLGAFRELGFEFSRAVFGLQQRTPRWKSCTANVNANFGVALSYLYVKRHFDYDSRQKAIEMVEDVREAFAEAVESLDWMDSTTRLKTLNKLKAIRNFVGFPAWLLTHEQLDKHYKHAEVVEGNLFETYLKLTFAAVKKTLESLREKPDRNRWVATATTVNAFYSATLNSVTFPAGILQPPFYGNGIEAINYGSIGAIMGHEVTHGFDDQGRRYDEEGNLKQWWSAATLEHYHSKVQCIIDQYGRYHMPQLPNYTVHGFNTQGENIADNGGLRAALRAYGRLQARASAERRAALPALPHYSPHQLFFLGFAQIWCGNSTVGALKSKMVEGVHSPNKIRVIGTLSNSKEFAEAWSCPLGSPMNPEHKCVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L397</accession>
    <name>A0A835L397_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_001689</name>
        <name evidence="6" type="ORF">HW555_007845</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000141">
        <property type="protein sequence ID" value="KAF9414145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000286">
        <property type="protein sequence ID" value="KAH9640337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L397"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="79"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9640337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="199" mass="22263" checksum="F4888DF4582D4998" modified="2021-09-29" version="1">MHVLRMSCRAGLGNKHSIALDKLTDHEMIIASQLVVPDEISVNWKDIAGLDQLIQELRETVILPIQKRELFADSRLTQPPKGVLLHGPPGCGKTLIAKATAKEANMSFINLDVSLLTDKWYGETQKLAAAVFSLAVKLQPCIVFIDEIESFLRTRTQHDHEATAMMKTQFMSLWDGLITEPTCTVIIMGKSTSFFHILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3A4</accession>
    <name>A0A835L3A4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000500">
        <property type="protein sequence ID" value="KAF9407158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3A4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000006">
        <property type="entry name" value="Basic leucine zipper and W2 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="232"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="45968" checksum="B38F98FF2CBF830A" modified="2021-09-29" version="1">MLENEKEKYDPNGFRDALVQGLERAGGDLDAAYKFLDAAGSKLDYRRYGEVIFDVLIAGGLLLPGGSVSMDGESPKTNTCIFTANEDMDTMRNFEQVFVKLMRRYKYLEKMFEEEMKKVLVYLKGFEPLQRIKLARMTALWIGNGCVPPSVLLVLVNEHLLKDNLALDFVLEVFATVKAERGVTSLVTALKRGQLEGRLLEFLPLNRRSEDVLAASFASRGLGELLRLHRAQASQEARRELTQALLDELAEDKPVRDLIQDLRDMAHKHSIPEHEVVAIIWQCVMSRGEWNKKEELLAEQAAKHLRHYTPLLAAFAQSAKAEIALLTKVQEYCYENMNFMRAFSKLVVMLYKTNVLSEEVILKWYREPNSSKGKVMFLDQMKKFVEWLQSAEEESESGEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3T0</accession>
    <name>A0A835L3T0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000425">
        <property type="protein sequence ID" value="KAF9407890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3T0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1275" mass="145311" checksum="83FA093E19DBE3F8" modified="2021-09-29" version="1" fragment="single">DAVPLKLIPGERNVIKDKGVTHTISRFYVVPNDFSKEVSVKALHSDHESSNSEDSVTNDLLANIDGTLTNANNNTSGNNVSSTKKSRTTVTILTKSNILNETSDTGGLELLVQPISGKKSTNDNVSWNTSRAGEETNDEVLTKITMDSNKNDETSHQSNDQRLNIVGRNKISEENVENEKFSNSVTKQIVDDSANKEVLLANTITNEGHSKRSDEVESGNDLHQILSENIENVSPIVYTLKEPTLTSDNNTRSIHHTNLDGLLLTNSDTTNLADNTEDENTSSLRTRNDEKYIDPAIEPGVKNDLPWKTNDGTDNHVAWTVDNRVENDLPWHIGDKTVNNVPLVVEQRVKNNLPWDIDDKTINNVSWAVDEGVQNDNNVPWPVEGDERVKNNLPWEIEDKTDNNVPWAVDDRVKTDNDVPWPVDVDERVKNNLPWEIEDKTVNNVPWAVDERFKTDNDVPWTVDVEERIKLLNNVPWVVDEGVRTDNNVPWTVDQRVKNDLPWHIEDKIKTDILLTLRGKKATNNVASTVPKKTTFDLPWTIEDKINNDIPWTIEEQVGDSGYIVKKKIYKNIPWSSESKITGTEPWYVSQLPTSLYQSGVVSHGVTNKQPYYVYTYVVHPASVGPSSILHEQPDLYDILNVKHTQYNTKFEPNIKHGYKISTVNAAMEPLKVSKQSNYEVQHNGVITDKTISFLKKSQHISQNPQDFIIDADTVNPKITNEYSHTLEKNVATPKIPLEYSLNINPFADLTESQDLTQEVFQGGIRNIDNVNSNFINPKITHEYSYIADKDVSTPITSQDYSYSIYNDNKVPETLQDSIRLTTAGTVIPKVIHDYSYAKESNTVNPYSPGPLNLNVDFKGVVASTPQDYNLDINSGVIPNSIAHYKYEKKVEIKNNVHQGPLNVHSKDSENDHSLVVNPHLDSKIISNNPISSHKISYLNLLKNKFHINPHSSNVNFKATIQHQNTDQNYINKNIIQTHQTSNLRLVPTYRLFTVQNLLKLTNGLKRLIPSVEINVQEQNALNNLLKVLQILLIQADYFGLQNNWYEKIFYNVPPQNRHPLQTYAYDLIRQRWLHELLLILHENDFNLNILRNPGIITLLVKWQFPQYVQSYLKEEHKRGWYYSVQQNNVNPVNPSYHQVVNNYACQYCAANLKNFVANHAYYSPQTGESMMNIARKNFVIDANVVRSILQNFYLNKNAIEVKEKVSMEDNKTAMLRQIILYLTQKGYRTQIITDLIHKLDIAVLSTVNKDCRVQQRNFPQQLYAVILSILRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L414</accession>
    <name>A0A835L414_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L414"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="689" mass="79353" checksum="114EC180A248CA48" modified="2021-09-29" version="1">MTSSAESKGLVGKWMCISIVNRIVFAGYPSLWNVLFGFWPITLYSFVVLRRLPDTTGIILNDSLTHALSRVRWQQQTDRGRIGSVATLENQRKSNIPCDHVLSHFFKYRRILFDCFWLQQYWIDRRPELFPYFAVTGNKILSFNDWEIIQTERFCGKKLCNCPIIGKDGGPGISFHDFKFVSELAVVLATAILLKTVVRDKDVSRSPVNNVGYQLATMFAGCAGRQRVRLCQYGPCCAGVRTLHDFVAKEIYLSSARLVKLATKESEEHVMDKNKSIDLNISTSTDIDEETDKRESPLPSGFENQLIKLNELLGDVFNEDDASTKENIEPTAPSSEKIQSTSSTTKNIEPTVSSAENIEPIASTSTHFEIIVDHEITPMPSPSSNEICDDTFCVGYAESENPPILTNDDLYGNLPTPSVTSFSSVYTPTAQSKQTRQPTFKRDKGKKRLIHKENWVTMFLNTISAGERIVTTSWKKYDGEMTVSDDKRGKYIHKTNVMDEEMIRSVCDHVKSFSLVESHYIRKDSKKLYLEDVKSASRMFNLYSEWFDSDKYRNKASTKRQYRDILNANFNIGFHKPKKDLCDVCHWTRLREVTVHALHYDRIEYKYNFEDEPKTIKILRSGNRNTERLSREFEIKQAYDGDLPISRNKYKDLINLCQTNIIPEKYHNFYQKLKFDQNVQEPLEDIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L488</accession>
    <name>A0A835L488_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein futsch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000105">
        <property type="protein sequence ID" value="KAF9415670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">ABC-2 type transporter transmembrane domain-containing protein</fullName>
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        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
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    <comment type="subcellular location">
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000158">
        <property type="protein sequence ID" value="KAF9413474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4J7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051449">
        <property type="entry name" value="ABC-2_transporter_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30294">
        <property type="entry name" value="MEMBRANE COMPONENT OF ABC TRANSPORTER YHHJ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30294:SF38">
        <property type="entry name" value="TRANSPORT PERMEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="151"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="540" mass="60727" checksum="8A1C249AF4D12D17" modified="2021-09-29" version="1" fragment="single">IWDFLAEQARRGTTVIITTHYIDETKQAHKIGLLRDGQLLAEDSPEDLLRKFDCDTLEEAFLKLAMRQHEMPRRRSTLTASPDVIPDSSMCAPVDNRYHSRDDFPTITSSTDVSANKEGEIKRQQEIKEFSRYKAVFIKSIQQFARHPGGLIFSILFPIIQVVAFFAAVGHDPRDLQIGVVNDEAAFSPFGLKICSNTSLVTTVLQEDETCDLYMLSCWFLEEMEKKMLFPTVYNSTEEARKAVATGKLYGALHFSRNFSSALGKRVADGEVDDDIVEDSSVSVWLDMTNHQISNFMKTQLHKAYESFTRRAMTACGRPENLVQIPVHFEKPVYGKSEPQVVSFMAPGILITIIYFLSAIVTSTLMITDRLEGVWERSAVAGVKPKEMLNVHITLQSVVILLQTIEMMALAFIGYGIPSVGSKLVCGLLLFLQGICGMCYGFLLSVYCNSHTMSFFVATGSFYPMILLCGILWPLEGMSYTLRMISLTLPFTIPSISLRNIMEKGATIMDKSVIYGFLTTIAWIVITLALIYLRLRFKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4M9</accession>
    <name>A0A835L4M9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4M9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="25158" checksum="3CB14CF308988199" modified="2021-09-29" version="1" fragment="single">MHSEICISAFFSAPIEENIELSNSEFNQELQQQVGRGIKQGIITNENKVTKKAKLNEGASTSSIETNDVDNNKVECDTCHVYIAKRYLNNHLKSNTHKNNLLKLHNSLPNVTVVETAFGNRILTYRINSKTHQSGQYFETPESFLNSLKIDILFLINECIQQHTILKINFIMHADFIQQTKDIKNTLDQLAKNLNDDQFTELKRNYPNNEDFSRLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L539</accession>
    <name>A0A835L539_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1502"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1655"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1681"/>
            <end position="1705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1714" mass="188926" checksum="8E902E3564A07444" modified="2021-09-29" version="1">MGKSHQDVKKSTVKIQDSKKDSATRLKHLKIVLEHFDTDEAKNYFEGNFSHVYFILYDNFIQAENNLRQRVHKAGREELEGALSLLDKVLCLLPELIGKRWQLHSLTRIFSKLLHSGNSQKLRAEAIRYFLLWYQALGDNAPNEVHKMFATLVPGMPEPTLMPIGSPLKPNITANETHGSGDFSIEDIMHHPNFNSAVDNAKKVVVEQTPTGIMGKIANVSASIFHDTNALNPVQSVEIQPLLPPSANEKAVDNETKYFFDILLDGMATSVTKIQWRDRCHTKAMRCFAFLLEKFKIYYLPVICPQFNVKNSLYKPNLELPVQHNILEDDYVLCRVTLIKWVASYAHFMKKQGSDGGQPSSMTSTGSHLPHSNTPTPATSLHHEEETSFTVGHPSDSSRASSHDSASNTPHPSLESGSGVFEELSSELVVRDVLCCSSREHVDFTIEVLRQAFLLPFSHAAAVRRVIALYKDWIQMNVAEMPPFLMENTFEQQGGGEPALPPRRLRNDSYLGAVGRDNIMVRAGLQNVLQIFMTQAANVFLASASPVAPPGALNQQQLLEEQTDTCKRVLNIYRYMVMHVAMDANTWEQLLLVLLQITSLVLTKVPPKRKQESLGGFLAPALFQTLIVTWIKANLNVAVKPELWQNFMELLTRLTHWEDLIKEWAKTMETLTRVLARHVYSLDLSESSADRGRGGKSPKSGHEPHPRKEAGSTRRQLTRSRSDPHLGKQNQPHTETKEQTNDKPRRWYSLDSLRNSSQHEERDSASGSRSPSPAPSSGVESSSIKDSPLQIDLASDGGNVGSLDIGMPEWTENESGESLGGASVLWRRMLAALGDPNLLRDPHAHANLYNYLIHLNSTLLKISANQTLNGNTEIHVPFNLVAGWCLEAEALPPSHRAGKLLALRLLCESTQAQGPGAPSSCNNRLHLAHLHLYQRALHHGLTGEDRSVVDVLVEHAAPRYLSLALDGYSLLLLDFVHASTVVLNSSDMGPSCPRTAAVTFLGSLLSLPDGLMNAPMLQPYPHQYNTVSCPDLKEHVLNIVVRVCRREGSAAARCAGACALTAHVCHLLATRATAPRLPSYVTCLLQMLMMKNKNIAKVVSDCVLALADYTDRIVELYPGLAGKIIKWICACLAQISPSSSRDSVKPLAGSLLLCLAEFAVRCGPSYLMQEKDGDQTLLLMIFKVLYAVMKGTNGSDIEGLSLPVDEDFDPNIQLDNLGPKTTPASTIDVKLWAQTICTQLVLFLGHWPLWNGWQVSSSVCEQHDSPTLGGELGPAVLTAPHVQMMRLSESTLASFIELPALDMPAATTPGLMTSDKQARVLLRDIAGKACWDASALFYDPSVTSTETIEPLELPDTDECPRDNTLSSLPPPLPPDLLPDYKNSPPDKHQLDHVLAYIGHTSPEVVCGRRLDEAGPSPLPPGAEDELVATLVAHRNSERHYLATRDSTSYSYEEDEAAPSGAAVNARPFGVCRALAAQLGTLAPARRTHAHLLRRTDRLLRDLRNLDAQRCRETHKVAVIYVAKGQENRNEILSNRCGSPAYEAFLAALAWETRHLGNDEVHVVWSEHWRPYKRDTLPTQFCDVLIVLYPLPGGLLRCTVSRKPDRARELAALVAAHSLPTTFEAFVERMRDPVPSAPPADHDQGTGRLAAALLDHGASGWSGGGDNHGVSPRPSKRLGPFKRPPQPIHPAPHTAPPLSGPPPLAAPAPASRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5B6</accession>
    <name>A0A835L5B6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000279">
        <property type="protein sequence ID" value="KAF9410070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5B6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="246" mass="27946" checksum="5EAE8F6451488A92" modified="2021-09-29" version="1">MESKLAASFEAMKATLLSRMTAHEEKLEKVTAGNQPPADIAGLQSEYSDFKRFVLDALHSFGTQIELLSQGYDRHETVMRRKVLLVHGVPEAKQEKLPDVITAVLHDRMKLTEVGRSNIHVCHRLGHSNRGPRPILVRFFTTEHRHLVWDNKKSLKGTGITISEFLTQMRHRAFTAARKHFGLTNCWLDKSRHKIEYMSELEELITKFRRCSSVGDDTVPAGDPNLAAGGDPLAKTLRRTRNARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5F6</accession>
    <name>A0A835L5F6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_006338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5F6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033103236" description="Calnexin" evidence="10">
        <location>
            <begin position="31"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9416264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="71163" checksum="0D85D4D12525BAF2" modified="2021-09-29" version="1">MHFKMALFSRKVYLLGAFLVLLNALSVVHADEPKDKDGDDEATVETVEEENLYQSPKISPEKVYLAEHFDDAAAFKKKWVKSEAKKQGVDENIAKYDGKWEIQQPSRKIFKDDLGLVLTTEAKHAAISTLLERPFEFKDKPFIVQYEVTMQEGQNCGGAYIKLLSRGTNTKADLRKFYDQTPYTIMFGPDKCGNDNKLHFIFRHKNPKTGVYEEKHSKKPTQRLDEIYKDKEPHLYTLIVRPDNSFSILIDNKEVNSGSLLEDFAPPVNPPEEINDPNDKKPEDWDEREKIVDPTAKKPEDWDEDAPAQITDPNAVKPDGWLDNEPEMIPDPDAKKPEDWDEEMDGEWEAPLIDNPVCASAPGCGKWKPPTIPNPNYKGIWRAPLITNPNYKGKWTPRRIPNPDYFRDETPFRMTPIHAVGFELWSMSPMLLFDNLIITDDLAVAEEWAQTTFALKRAKISRDSQTLWGRMLRAMNYKPGWWALYAVYVAIPIVAYIVCLVRRAKEDSVFDRAMRFAGDNPWVYALLIVVTFLVVGLIAYACFGSKSDSDADMKKTDAVAEDDPHLSEAEEELREEAERPSKADLEGPEVDNDAEVVTSTEDTNPLVDTEGAGDGQRKRKPRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L645</accession>
    <name>A0A835L645_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000103">
        <property type="protein sequence ID" value="KAF9415740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L645"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="20463" checksum="096EE68129AB7A6E" modified="2021-09-29" version="1" fragment="single">PSPVDSGDRLPTEEPCAFGYLDSKGFSSSKDVTLCLLPSGALMKIAPSWNSLTETLEPLKPVLALQTDILASMLANLTRIGLVTLVQSSPAVSAMPWKMRALRRLLVSILSSCREHSPIWRRSSPSILMTSSRKARNSSATFATVSLAGPAVWICASSALIFFIKLSSSDFCADNTSASWDIVQCLCFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6E7</accession>
    <name>A0A835L6E7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6E7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="16278" checksum="B129E3DDB4EA19BB" modified="2021-09-29" version="1">MSIGQSEAMIPAYSVTALRLAFDEISTVLPIANQLACLLIPFLINLINNLNNLSNIVQNLTPALLPYFGCTLPLLYATLTDLASVLFLYISVLISLFRSNVLAAPGLLLGLVSQVLNLVLNLLSGLTDGSGLLSSLIKLITNIVVELEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6H7</accession>
    <name>A0A835L6H7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6H7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="N-ACETYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538:SF4">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="11761" checksum="7BBCC0B480A45862" modified="2021-09-29" version="1">MMFKMDAGDLQVLRLHENPQYLKPCVELINDEWPRSETARMMSLQASCDNLPTSLILVNDKKHLLGHCKLTPIPSIPESCFIETVVISKSMRGKKLGSFLNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6L8</accession>
    <name>A0A835L6L8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6L8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF94">
        <property type="entry name" value="CCP84AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="20979" checksum="E7A63926598E4DFE" modified="2021-09-29" version="1">MAHHHKFTVKILLPPPRAGVYPAAPVAYSAAPAYVAHQAYAAAPAHVVHAAPVAYAAPVAKVVAPVAKVAVEEYDAHPQYSFAYDVQDGLTGDSKSQHESRDGDVVQGSYSVVDPDGTKRTVDYTADPHNGFNAVVRKEALGHVAKVVAPVVAKVAAPVAYHAAPVVAKIAAPVAYHAAPVAYQAAPVYHSAPVAYSAYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6R3</accession>
    <name>A0A835L6R3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SEC63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6R3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF5">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="9">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="275" mass="30608" checksum="13BE208CC2E12278" modified="2021-09-29" version="1">MYRGLPPRVPHKPSSASGPVKYNDPHVKAHVLLQAHLSRMQLPAELQADTALVLAKAIRLIQACVDVVSSSGWLSPAVAAMELAQMVTQAMWAKDSYLRQLPHFTADLVHRCSEKGVETVFDVMELEDNARAKLLQLSPTEMADVARFCNRYPNVELTYEVVNERHLRAGKPVVVEVSLEREDDIAGPVIAPFFPQKREEGWWVVIGDPKTNTLLSIKRVSLARTAKVRLDFVCGAPGRHTYTLYFMSDAYLGADQEYRFTAEVAEAASDSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6S1</accession>
    <name>A0A835L6S1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6S1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="263" mass="29134" checksum="1C82CEAE326685DF" modified="2021-09-29" version="1">MFEDEETVTKKKKSKQKENSNVDVSAILGILANLTYDYEWNLTEEFNRTLIESGVPKCPTPTESTTMSTTPLPYDFANTSVISKCFVCGLKTTDIPRTAHCADAFSGDFLPLAPVDARAKGHIASFRKYCRHLDVHNFVENPLEPHSIYGRFTGGCAVRWTDLSGVYTQRTCRAKHRPLLGKHFGSKRLAKLELALINVKNGCIASPMATLLPLSRGISLYARFHACVCTGNWCNRAPSAVAPPLHRALQALLSHLVIRRLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L716</accession>
    <name>A0A835L716_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L716"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="99" mass="11165" checksum="29E2BDCE44DA078E" modified="2021-09-29" version="1">MVGADYVGIGGDFDGVNRVPRGLEDVSRYPELFAELLRSGQWTVQELKNLAGLNMLRVMRQVEKVRDEMRTNGVEPEEHPDSPNDNGNCTSNAFYTEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L744</accession>
    <name>A0A835L744_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_002445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L744"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000046">
        <property type="entry name" value="AGAP011765-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000134">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF23">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Reelin" evidence="13">
        <location>
            <begin position="39"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="14">
        <location>
            <begin position="203"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="12">
        <location>
            <begin position="654"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9421764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="805" mass="89472" checksum="A717178ECD59163A" modified="2021-09-29" version="1">MSRFDARGRRCLTLYLRSGQRAIPRHSAADTRASLGDMWQLCVVLLVAAHAQACELRPREPARPKSPGDNFYRLIVNGEVERYAPGQRYVVTLVGSRTHDVVQQFMRFQLKLDPLDPAALRAPSKQGQFQLFADTLTRFDEECTNSVIESDDLPKTEVQVMWKAPPAGSGCVLLKAMVYENASRWFAEDGQLTKRVCEDTSLQSSDCCACDDAKYRMVFEGLWSPQTHPKDFPVQAMWLTHFSDVIGATHPKNFKFWGEGEIATDGFRSLAEWGSVGLLEAELRQQGSKLRSIVKAQGLWHPRVNSNTSAAFTTDRKRPFLSLASMFGPSPDWVVGVSGLNLCQKDCTWAESKVVDLFPYDAGTDNGISYMSPNSETVPREKMYRITPMYPEDPRAPFYKPGATEVPPMARLYLTRERLISRSCDEEVLLQQVVEEEENTQTVSRPECAVTEWSAWSQCSVSCGKGLRMRTREYRMPQKAQMFSCDRQLVSKEMCVAAVPECEGDNGVPEDSDNNATPIEANEGICETSEWGPWSECSVTCGVGVSTRRRHFLNHMGIKKCPLVATEENRKCMEPQCAEEEREVSDPACPTTEWAAWSPCSASCGRGVRFRMRLLLVPADRQQDCSAKVELMQQRPCQERDSCAIDMLTAKRICMEEADPGPCRGLYQRWTFMAQKGMCVPFAYGGCRGNQNNFITQEDCTNTCSVILGGGAPPAGLPPQLGPVPGPLPGPTLNNAVPTSNNVNGPSLAQAGDCQVSPWGEWSKCSVSCGTGYQERTRTVLVQPGPGGAACPRAMARRRRCYRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L788</accession>
    <name>A0A835L788_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 20">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="20">GNT-I</shortName>
            <shortName evidence="20">GlcNAc-T I</shortName>
            <ecNumber evidence="17 20">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_003161</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 20">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="20">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Golgi apparatus membrane</location>
            <topology evidence="1 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="17 20"/>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L788"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.20:FF:000001">
        <property type="entry name" value="alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000055">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9420614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="443" mass="50665" checksum="E21A98031B0A3FBB" modified="2021-09-29" version="1">MRLNVKKALIFVGCVVFLWLLISYASVIEVPRPAPQRDPTVEIENKIIKLQKQVDAQMAESKSLLAKVKKLKRISEGENTGGEDENLKDAEVVQHLTQPILPVLVIACDRVTVQRCLDNLVKFRPSKETFPIIVSQDCGHNATYEVITSFTASDPSISVVRQPDLSEIVLPRVKVKFRGYYKIARHYKFALNHVFETLGHEAVIIVEDDLDISPDFFEYFLGTYPLLLKDPSLWCISAWNDNGKMEVIDMSRPDLLHRTDFFPGLGWVLRKEMWVKLAPKWPAAFFDDWLRNPVNIDGKACIRPEISRTYSFGKVGVSKGLFFDLHLRNIQLNMEYVEFTKLNLTYLLKDHYDESLASTVYNLPEMSASEVVASSDVSSDPVRVMYSNAKTYQRAAKKLGLMDDFRSGVPRTAYRGIVTCYIKGRRVYLAPTFEWTKYDPSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7T4</accession>
    <name>A0A835L7T4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_010415</name>
        <name evidence="5" type="ORF">HW555_008506</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000177">
        <property type="protein sequence ID" value="KAH9642762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7T4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9642762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="19554" checksum="F8CD6703EC312BAB" modified="2021-09-29" version="1">MVRRYERMSGRQSWNEDDMAKAVAAVVSGKMGYKLAARTFHIPRSTLQRRASKIRYQQPDDPKPLMGHYRRVFTDSQEKDLVGYIKSMEKYFMGVSRRDIRELAYQYAEDNNLNHPFDANTRMAGEDWVRNFLKRNPELLDKSDHECGLEPVNFDQFYHFMCQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7X6</accession>
    <name>A0A835L7X6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7X6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000392">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF87">
        <property type="entry name" value="DPR-INTERACTING PROTEIN BETA, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="183" mass="20401" checksum="EE9DD9FDE28686E7" modified="2021-09-29" version="1">MPLGLEPDFLYPLENVTIAQGRDAMFTCVVNNLGGYRVSGDSATARVAWIKADTKAILAIHEHVITNNARLSVTHNDYNTWTLNIRGVKREDRGQYMCQVNTDPMKMQTAFLEVVIPPDIIYEETSGDMMVPEGGSAKLVCKARGYPPPKIVWRREDGGDIISRGGPQGKTKVIEELTQYFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8K7</accession>
    <name>A0A835L8K7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_003469</name>
        <name evidence="9" type="ORF">HW555_007714</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000488">
        <property type="protein sequence ID" value="KAH9636651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8K7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9636651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="340" mass="38599" checksum="D30FBA49B511A1A4" modified="2021-09-29" version="1">MDGNNIIAIKDGDPTRPGEVDAPSAVDVPKQLEGLTKKKRRRGKSKRKIMKPFSKIPWQDRRKNEKSKRNNRFRKIVMAKTHAPFNNNQFLMEIHKPEPENSFHLLRTPSARTRDSSFSVDSEDNYFFSLPEDEEEYLTKEFSSVYEDAQSERLSNMSKDDLVQEYLLLEAKYDNLVKRTERSRAKFVEEDKDMTVNDRDTSVTDRDSMLTDRDTSGTSVGSSVVDDQSFSDLMLRMKEQEEQIRSLQIDNEKLRLEVEHLRQHSQDTSSADSESDSSSSSDSDSSSSGRASPIADPVGEQNLVEDNLNGNCVHVNGQNEETEGSGAPYPMVNGCHDSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9T0</accession>
    <name>A0A835L9T0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9T0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="91" mass="10135" checksum="BE224F49A680787D" modified="2021-09-29" version="1">MEVVKMPCSAVTLSIATITAIVAAALMAIAFSTDNWLYIEVKRTHIQVSFLYSFTNKLLCELLCQCVGKSVGQTHFRRDIERVTLSTESGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB55</accession>
    <name>A0A835LB55_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="6">
        <location>
            <begin position="166"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="465"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1293" mass="143221" checksum="EF166E35CB231DD9" modified="2021-09-29" version="1">MVCFKIFDLDSDGVLNKKELIDMVGILCTVANESLKNQGSRASTPSDSNDSESTEKGFDPEVILVNLREKLVTVPKNGRKPVFQLGPNGDDNKEEIIVLKEQQQQEQQDETQPEDDLESEGLIANDMALTLEDFLIWSVESAESLVTPFLDLLFEVCHIVLGLRPQCKHQERDIVLGWLRRAVQRGYAVGQFWYLVGAEWWANWLAYTSASSTDNCCRPPNRHIDEAIVCDESFTSNSTDKLLRIRLLAAAPGAARRLTGEGGHLRRDVTLAQHHDFELVPDALWRALALWYGGPDPLPRQVIRPPNSDVELELYPLHLKILRHVQTPQRMPPGGVAGAGGAALYSGVAPAPPERQLAYTAAFSRLATVKQVCDFLCAALGLAREDVRLWLVTGGSAGSGGVLLDDERPTLASLGLDERSRLLLELRNPDLTWPEEIGALSMSSGSSRATERRETLIAPNLPGATGLHNLGNTCFMNAALQSVWNTGPLTRYFNSGMHLYEVNTTNPLGTKGVLALRYGELCKEVWSCSARSVAPLRVRWCVSRWARALAGGGQHDAQELLAWLLDALHEDLNRAPAPRPAPAQPAPDSAGRADRVVAAEAWAQHTQRNASVITDLFYGQLKSKVQCDTCGRDSVRFDAFNMLSLPLPMESYVCCEIRVILLDGSVPIKYGVRVNSEGTYLDLKKKLSELCGLEPEAMLIVELSGAMIGRVFEDGAKISAASATELFAYEIPRDDPDTDCSDCEDYTHETNGWSSESPQWAEVSVGGGNTSSLCMPALFCFKSPPSAQYTHGVTPARCSTLPRGTRRDPTARDASPTPSARSLTLAPRSPRLSSVKFGSSPSDMCRLGDSREAPGKIQYLVAVHSLGYEFPFRVRLVRRGAAWCARCAWPRLCRGCALPSDDTPLDHCGKRRRSKRPSVTPAAIDTDVPNTNSPVAKNKLNRHATTRLSDDMSGECESGEVGARELGALLAGSRRGDIMLAIDWDPTALHLRYQSTREKAWVEHESVGRCRAEAGRAIDLASCLRAFTSCERLEQRYHCAHCRSAQPATKKLQIWRLPPILIVHLKRFQYVNNKWIKSQKVVNFPFQDFDPTAYLASVPQETILRHTEILNSKRRSSVFVDDTISESDSENEESNVQQKVQRPKVERKRRSSVETKGRERLESTSLVTTPVTDDNLIDYHGHHLVAEQDPFELKYRLYAVVSHSGQMSGGHYVAYARNPSGAWLCYNDSSCRELPPAPAPPIDPASAYLLFYERQGLDYDRYLPDITGKEPVVRDAEVLDPDENDLKKMCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBK1</accession>
    <name>A0A835LBK1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein RIC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBK1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="5">
        <location>
            <begin position="124"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="677" mass="74168" checksum="F4B8CE893C7A7F0B" modified="2021-09-29" version="1" fragment="single">AYSCLPATVLASCVESVWSCGSVTGSQTQLSRALWLWCGALGARVWLPLLPRDTTRHPDSSRHTFMAKRIMLPFHLNIYPLTILFDDAILLGAENDTTLYASDSSSVFSLPFCVVNRTSQVYLHQILRQLLRRNLGYHAWEIARSCSQLAYFPHSLELLLHEVLEEEATSKEPIPDAQLPSIIEFVHEFPVYLQTVVQCARKTEIALWAYLFSAAGKPKELFQECLHRKMLDTAASYLIILQNLESSAVSRQLATQLLDTALQQERWDLARDLVRFLRAIDPNDVDSPRNSVNVQAKYGQVVQSQTVSPNAEDLSVILGNMQLAGGRGRSFSTTVSPREPSPPAHAPPPPAPPPHAPPARATAAVKRKKSVPARSESFTSPPNRDSYSGTAEEFFIDMMIQRHARLLLSTARLYALGKMAAALDLHLVAWLAGERERAARVDNAVLCVKKLHEDFAWPYPVINESEQYLQRKGSTVASTYTPSAESDSLCGDSGYMSLPLRAALPLMTGAVPVSPGPVSSAGEGSVAEGGGVAWGGDALGAGEERRYAALMERLHHHQAERGSHTAHVQLSLGYKPFMMAISNQIPFLTSIINTRERRLSMTKSRVRTPSTSSLGQEVKPKPQSQETKLPPPQKAEVTKQAARKESAGAEPAPSVAPPMPRPPAPARDDVSTGCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBZ1</accession>
    <name>A0A835LBZ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_003380</name>
        <name evidence="5" type="ORF">HW555_004685</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="410267at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF111">
        <property type="entry name" value="CHASKI, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="128"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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            <begin position="450"/>
            <end position="517"/>
        </location>
    </feature>
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            <end position="57"/>
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    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF9418536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9645707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="799" mass="88987" checksum="50D39944D9625FB6" modified="2021-09-29" version="1">MEQDWEPVILRSTRTPKNRELVRESAVRESLLSESTSGICKGEEDDTTSVGTASFSSPDLEFSTRERLPTIQKKLPNLGDEAIALLDKPKASNVKITVNPADRNVETKKHDDEKSDKDKVKIPDGGWGWVVVLSSFVISMIADGISFSFGLLYIEFLEEFEASKSTTAWIGSLFIAVPLLSGPVMSALVDRYGCRSMTILGGLISTLGFVLASISTTLEMMMITFGVIAGLGLGLVYVTAVVSIAYWFEKKRNLAVGLGACGTGVGTFLYAPMTQYFIDEYGWRGTILLLSGTLLNLCVCGCVMRDPEWWIQEQKRQKSSRDEGKLKKDDDKSRHSSSASISTPYVFDFDAPTRGKSMVGLIKRGVSPEKVIKQEADNIKRHQDIMKLKKSKRLNSKSQSVENLPTYLTYSEKLSMGTLDTLVKKTSRAYGIEVKYPAFAINRTKKQLLKEPSNESNDPPVVKYTNDVLQRTNSEKYENRDKASDKYELKNPKRKAMRKAKSETKDDKELVKQDSKENRKDWLKKQLSVNHHYLRDLKMPLNSISHRNAMLNIKRYRLKASSCPDIFKNSMITIDEKEENWYDDCFSCLADMFNVTLFKRMTFNLLCLGTIILFIWFIVPYFYLAEHMIHKGYTDDEGAGMLSLIGITNTIGMVGLGWIGDFPQVSIGGLYAVCLVLCGASVAAIPPAAATNYWILASAAAAFGLFFAASYTFTPSLLVKLVSLDDFTSAYGLVLLAQGIGHLIGPPLSGFIYDVTLSWELSFYLAGGWIVVAGILVSLIQPVKNYQLRRAALDDVSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFP6</accession>
    <name>A0A835LFP6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HW555_001108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFP6"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032296872" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9248" checksum="B0A6D03D9B4763E7" modified="2021-09-29" version="1">MRLTALLVLAVLALFAGGAQSAPSPNSGFDLEGLQKALTKFEEGLQAMKTMVKNGYELYQIFTQKNKKVPENETLNKGNIKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K1DDI7</accession>
    <name>A0A0K1DDI7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemosensory protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CSP11</name>
        <name evidence="5" type="ORF">HF086_008926</name>
        <name evidence="4" type="ORF">HW555_000174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>Putative chemosensory protein genes from Spodoptera exigua.</title>
            <authorList>
                <person name="Liu N.-Y."/>
                <person name="Dong S.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KP729029">
        <property type="protein sequence ID" value="AKT26487.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000188">
        <property type="protein sequence ID" value="KAH9642516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K1DDI7"/>
    <dbReference type="OrthoDB" id="6344725at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035992530" evidence="2">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AKT26487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9642516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13822" checksum="4FCE15F021CFCCD3" modified="2015-11-11" version="1">MRVLVVLSCLVVVAFAADKYNPKYDNFDVDTLISNDRLLKAYINCFLEKGRCTPEGSDFKKALPEAIETTCAKCTDKQKGNIRKVIKAIQQKHPKEWEDLVKKNDPSGKHRGNFDKFIQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3X9</accession>
    <name>A0A835G3X9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-serine deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_014347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000990">
        <property type="protein sequence ID" value="KAF9404419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3X9"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01840">
        <property type="entry name" value="SGNH_hydrolase_yrhL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006390">
        <property type="entry name" value="PRK08639.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9404419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="514" mass="56965" checksum="4177AFF15BA8ED22" modified="2021-09-29" version="1">MKVTATIFMPTTTPQQKISQVKFFGGEEVSVKLIGDTFDASAKAAKEYAQANSQAFIDPFDNINIIAGQGTVAAEIFNEAKKSEFQVDYLFAAIGGGGLISGVSTYTKAVSPTTAVIGVEPLGAQSMRAAFNEGKPVMLESVEKFVDGAAVKQVGELTYAHTLEYVDQLLAVDEGQVCTTILELYTKQAIVVEPAGALSVSGLELMKDDIKGKNVVCIISGGNNDINRMEEIEERSLIFEGLKHYFVINFPQRPGALREFVTDILGPDDDITRFEYTKKVNRGTGPVILATAPSNEVTADQQQLQKSIEENKKLADQRKAEEKARNEGEISESTEQSNSVTEANYDLTSEEIKKAQSMEITAFGDSVILDAAAGLQEIFPKMLVDGEVGRQLYTSAPAIQQLEKDKVLKDNVLVGLGTNGSFTEAQFDEFMAAIGPERKVYWVNVRVPTRRWQNEVNTMLENMKKKYNNLVVIDWYDYSNEHEEWFYDDRVHPNVEGQDVYQCEYPDSRLIEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G402</accession>
    <name>A0A835G402_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000534">
        <property type="protein sequence ID" value="KAF9406877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G402"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032457627" description="PDZ domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="216"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="342"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="493" mass="52418" checksum="8DD6B1C2CF27445B" modified="2021-09-29" version="1">MTTWMALFGLVWLLRVRGSLCGCAACRRARHDAQEIQCAPSPRAPTPEEQAPFDVITLEHYTRDVTVQTDFDDEDVEDLDKIEMQISEESNVGNYECGREQSTHSPGSGQQASSFQCPSDADSEAVWETADVTLERGASGLGLSIAGGETGSDVSITRLAVGGAAQKDGRLQIGDILLQVNDISVEGAPHSVAVDALQKAGSVVRLRVRRARRPRVVTLWRGVRGLGLGIAGGADDAAGGGGIFVSHIAVGGAAHHDGRLRLGDKILAGIETSLIGATHAHAVSALRSTGDQVTLIVLSAGSVPPVAKTAPLYSTKTQATSCSTLHELLEEEPSEIPRCVRMVRLVRSGSRLGMDIVGGLGGEVEGSTDEDACGVFVSGVSVGGAAYGMLHRGDRILSVDGRDLTRATHEQAAAALKQYSGATVTIAAQYQPEQYERLRARIRAINAAAAMSPRTRHVPVHPDLHAMYPRYLIGNIENVLKYLHNMLNVRVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G498</accession>
    <name>A0A835G498_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G498"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="55080" checksum="9E2A12C23400EC62" modified="2021-09-29" version="1">MLGDEAYRLKHYLMRPYPERVLNNERKCFNIRLSIARQTIECAFGILTTTCILHNVIMDLNGDLDLDVQHVLSNPPSYENRHRNRGVNNNPSRRAKNVQYWVHPILRDRLTHGMFVTLYPKLREHEPKMSIKSFDDLLDVIKVDITGESTILRESISPEEKLVITLRYLATGCSFADLHYGYRLGKSTIIKIVEQSGLSMSHMAGRFWISSINKSVSKCSVSIFGEICVHSTQKRAFKCTTKWRLIKGEFAAILSRVLRATVASTRCVPTREHLGRNSVRNMELNEAVSLWLAYRRWKRQKRRENRMYLVHPILNDRMTHSMFETLYPKLRQHEKKFFNYFRMSVKSFDDLLLLIEEDLSPRANYVPREDVVSAEQKLVITLRLKIRFNQRHGFGRVQDIHYPENLLMMLTENLRIMMPVKISALKYNCVLAMLLWMAFLGHILDKKIHLVLKVVHGIEPELRLKMKPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4B9</accession>
    <name>A0A835G4B9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000396">
        <property type="protein sequence ID" value="KAF9408237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4B9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14155" checksum="1E4F2A2F0C803365" modified="2021-09-29" version="1">MGKSASASRSRPILVKLRDVAVRDNIWFKKTQLKGVGITISEFLTKSRHDLFMAARKKFGVSKCWTRDGCVYVIAPDGSRRRITTLADIGTLKPQDAMKFPIEPEIVDTPQKPIIAGRSKRAAAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4G8</accession>
    <name>A0A835G4G8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000547">
        <property type="protein sequence ID" value="KAF9406791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4G8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38194" checksum="70C03C087090C3F2" modified="2021-09-29" version="1">MSIYELIASIKNKKCKMSAEDVEVKKPKDVFPIRHVQTMMMFFALVICYGMRVNMSIAIVVMTDKTLENSFDWSMQTQSVILSSFFWGYIVLQIPAGEMAAKFGGMILVTIAISVNALVSLAVPLAAYYGGWQMVCVCRVIQGLAQGFVVPSIYNLIGKWTPIDEKSRTGAVINSGSQLGNAIQLLISGFIADAWGWPAIFYVNGVVGAVWVVLYIILGSDSPQKSKLISAEERLYIQTSLGQVGGQKKLKTPWKAIWTSIPFISLIVLHCSQNWGYWTLMTEMPSYMKKVLDVDIKANGVMSALPYLAVYFLSFPFGYLSDYLPNKKYLSVTATRKLSNSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4T5</accession>
    <name>A0A835G4T5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_012522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000467">
        <property type="protein sequence ID" value="KAF9407469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4T5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9407469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="310" mass="35724" checksum="DD6A2CC6DB792551" modified="2021-09-29" version="1">MLNSIDGVETIDVSSLGPEAYGLPRNESGDALSQWSESSLMNPEEVGDYAEGDILMPPQQGRNGVRNEVLRWPKGHIPYVIEGYFNSEQRETIMRAIADYHRLTCLRFVPYNGQKDYITIQSKNTGCWSSVGRVEVNLQNPGCVSKKGTVLHELLHAIGFMHEQSRPERDDFISVRYNNIKPGAENNFRKSTVKQTNDFNVPYDYNSVMHYSEYAFSKNQQKTIEPKVGGVKLGQREGLSRGDVRKINNMYNCKKEYMPWSSYRPYRPYRPYRPYQNFYVPPGAPDWLARRSVPKHIRSKNTLICDCFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5L7</accession>
    <name>A0A835G5L7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000478">
        <property type="protein sequence ID" value="KAF9407369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5L7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF8">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE E13, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="102" mass="11738" checksum="DFAE4D7BA0A8626B" modified="2021-09-29" version="1" fragment="single">VPILYNGEKSFKQENLDKIKEGYDFIEKFFSGPWLAGESITLADICCVSNISSLNEILPIDKALYPKLSAWFEKCSKQDFYIKRNLPGVQEFRELLKVKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G622</accession>
    <name>A0A835G622_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000559">
        <property type="protein sequence ID" value="KAF9406695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G622"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="443" mass="50969" checksum="ECF93DF54C6AB78F" modified="2021-09-29" version="1">MSSLQLLKHAQFHGANQLGDKASRYIWGPTLLILLGPAIALVVLTVNRYLDRPTFMVRHDKFLEKRNFPSVIVCPEVNFVEQKMDNFLARLNYPPGTNATIIKKILPQLSAFYSLDMLYELPDLIRVEHVLDYNGISVETAGRCRWNRRIVNCSELFQMEFTGDGFCCVYREMESHGLNIKKSSPRRTWYTKLFGYTSGLMLALNQSQILTSVDLSYKWVALETGNHFVDITMNGTAVSPGSEHWIAYYTTGYQIALGAKTLHPSLRRCNMASEKLKYFPQYSQKYCTLEKEIANTLDKCKCVRNNHPRPPGTSRCRAAMLRCATQAMISYDSLSTDCPMTCDTKKATMKSSRFDLDETVRTVEPFYQGLNFKTVTVVRVFIQSRKRPTVERWTFYDYIDLFSQLGGMFSVFFGCSVLTLLALLQIVWRALYRRCLKFWSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G643</accession>
    <name>A0A835G643_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000306">
        <property type="protein sequence ID" value="KAF9409637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G643"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37328" checksum="034EA85A33A7D9AF" modified="2021-09-29" version="1">MENHDLSCEPMDIDTSGHSVRDMDISYDESSYTSTVIKTEKPDFVAEDVQVISDNRTSAIQPTVKKFHINMQRPSKSYNNVLFQSISVGVVILLSIFALHIYSLKCFEDFKLEELRTSLTHQLYGQTEAINTIIESLGQQERRKLIIFSGGTGVGKTLVSSILLNSLGPCSNVYHYTMPSFTNSFSTDFMYGLTMCKKSLLIVDDLTANDMHIRTQIQKVVEKSEYLGKEITVILIYNCYVSTADFKRNCDETFRQKLLENLKGIKVSTTFVDFKPLTKYHLKQCIKQELVDRHLNDKELEDVMKNFDVDVDGCKGVHSKMKYLNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G644</accession>
    <name>A0A835G644_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G644"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="162" mass="18034" checksum="7D1A2D40B7595586" modified="2021-09-29" version="1">MNDHVEALTMILMCGDGTCCCIPRRSMIALIAIISLGACLLDMLTTEKHSQFPENCSLICSEIECAKQLLMTLFQMANLLLLLASIVESAILVQLYVWYTLAFVVMGLIVNIVDFLFKYKVEGTSCLLGFVTEVCFLFVIFRCLPLVDTYRKHISGDSALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6J6</accession>
    <name>A0A835G6J6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000363">
        <property type="protein sequence ID" value="KAF9408755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6J6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="511"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64191" checksum="D002006E0B3EA566" modified="2021-09-29" version="1">MPCSRMNVPAQQQAVFLLPIAFKTFPNWMLKLSGQVIWRLGSRAAVRKYSGPGATVFKTEKLDLSTNTSDKRVEQLTGEDKDNSGLVAAAFASLQDIDTPIVKKPSPKSAKTSRLAHLDGLISQATDLNGLLVVAENPVVSRRHALKMVSILSEWTTSNKVKLTDFEKDPRFLKLCRILARSTTSQAIGSLTMAEDLSTVLGITGDDEAARLITNLTLPQMIKVMKALQSKGRRSTPLLRALSHNITNQAEIIDLKKSADLLYAMAALNFPDPVLLDRICNDVIECLPSNEDKSAVVNSITTSLGLLKYRHEPVLSAITDWLHQHIAQCRATDIASAVVTLATVDYLPPSDSAQGLIKTALTLKEEEMSKSSSWLDLVFSLLILNKAKKTQLESTLQPEFIDKLLSAGEIPIPSRRKLMMIDAFLHLASPGSPRLPEDISVGVPVVYTKEKAFYVQSIMDTFKSFVSAEAFLKKDCNSGMGFLYDAEFAVDAKCHPVPLDKAENNKSVFRIAVLGLDYHDMSRKSAVPLGINQLHTRLLELKGFKVLQIPYTEFSPKDKLVTRVQYIEKRLKEIVNKSGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6M2</accession>
    <name>A0A835G6M2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000496">
        <property type="protein sequence ID" value="KAF9407203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6M2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="448" mass="49322" checksum="A3CAD8232CF9A4AB" modified="2021-09-29" version="1">MGKMASNNFRARKLVHMVVNTDVCHDNSVRNTELSTSTLTIEIEPEDTKKSEDEIFTDRQDIASSQDVVNADFSLNLSSAALGDIRVSDYSFSKDESFGLLCNETLTHSLMGSPVADFGTEDEPTTSQGLQEIENQRSNESCPDVDNAPTTSNNQILVTDSVMQNEDNEAANRLVCDALKGTTKKGTPRIRKLYTESTNTRKEAKKQKKIEKFCVKPACTTSCKKKCGEKFSESDRNEVPVHELPSEADFLKRFRKERAFRCNSAELTNWVAIPILNNTTLRPVYPTGGQTHKIDYITNKIYASCIVVCDLYIIAIIIGSYLDVRPPNRIAAMDASSITLPISAKSWAVEITALIAFHASAAVVALRTCVIADDSRCLLIAPYLCDIGNVHPCWVATDRFPQLLMHKCPCPYCGSTHTGVYPASSSKAGAFTASRTSHICAYLTSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6U0</accession>
    <name>A0A835G6U0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000477">
        <property type="protein sequence ID" value="KAF9407373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6U0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="298"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="79985" checksum="470B5596E9278019" modified="2021-09-29" version="1">MMRPLWVRLQGGKRPLVAGQSTELVCQAVGARPKPTISWWKGGTRLKTVRETTSTDGNVTSSILTFVPTIEDAGRVLSCRAVQPSLPHSTHEDGWKMEIQHLPVAKLELGANLDASKVVEGSDVYLDCRVRANPWHNHVYFTHNGVVVKPGPGVLLANQSLVLQRVSRKAAGAYVCSARNALGEGSSENLILDVKFVPTCKSTQPIVVRAARGEIIEIDCDLDANPKESMSYHWWFNSSAHSKHELTTSPMSTVPNLPGTYVYMVNTSSDYGWVQCSGTNSVGRQTKPCLFHILPADKPSTPKSCEITNVTYDSLTLNCTPGHDGGIHQSFLLEIFDMATGLLLRNVSSDDPEFEVAGLSASNSLAVSVRAFNKKGFSEALTLTSNLLKYPQRHTAQVPVKVELTTVLIIVLGAVGVIATMTAVLAIIFCCKYCNKRERKNEKDKRQQDETSNIPLTGTKESESVDSLDKNPDIIPLDGKISDSCSNKSSTTDYSSIRPLISKTTDKFDMTANCDRFYDHNIDPCNQYIQVRPMEYRRPTYAPSLQMPNLGPSIQSLGPMSSLHMPNVGPNDCHRQPYDKVYEDWLKYKNALPLNTSGLLPAEQLLPPELYATPPPPSLYSNPNRNPLNLTQMPELEPRYHLEPRSLAMDSRSCSNSPPVRFNPENNSVYFSKGVLDRTTNTLPHLKPTRINGNSPTQLQSDQKPVTKSTETSLEAVKMSKECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7G9</accession>
    <name>A0A835G7G9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000354">
        <property type="protein sequence ID" value="KAF9408901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7G9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="664" mass="76154" checksum="6FAED77F1FAA98D8" modified="2021-09-29" version="1">MFSITMTIKALLVKYFPSIFHLSGDAKLDISCCHNPRNLSVVNLYDDDVRGGILDLSEEGFRFEIENCVALNVDRGAKGPDVLGGEEIVVILDDKNQYTSMPESGRQFLRSVPSSVEVREETHTSGCHQLYHRRSGDRTVYAQRIIPFERSENNQIERQSQTTVDPVLSSVRGKILDDYREYLDTLNSDEQKEEIVELIEKQVDIPIEDITDEQHDSKMVHQETLTKQSDSKAVKNKEIITEPKKSVALEEANVRNIPIKVVTSDGDATKTKYRKKEENISSDDHHKEENEPAAERNESTPETPGRAGDSKIIDISDGSGETLIIDGMDDAQLDKLVEIISMERKNTKKEQSTERKQYRDDTTSRNLTKLDGPNVRNVTTVMEVNIKRIPQSTTTMLPYFQMIDDLNEGYMVVFLIELMRIMAYKDKDDLFEVLVHTEQIVLQLYQAGKLIWLGQPVLDITKKLAKFVTEAETKVIQRCALELKRKLSGPTQRGYTVCLALIENFLKPYRRLSNTELRQQLLDSINLELRARIPEADREGNVLKFLGISEEMQQRPSVESDSGTVSFSRKIQNKLRQKLQKLKSKPKHTSNKRKKTITQPDYSNKNIFRRRFSNEPIASIQRRFKIVTRTLPYRSTASSYTENLISRPTKEFTTKLNKANNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G892</accession>
    <name>A0A835G892_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000378">
        <property type="protein sequence ID" value="KAF9408522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G892"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="588" mass="67585" checksum="EA9B3E949F52D7F5" modified="2021-09-29" version="1">MIANNRTDRSRSPHRSDNLGRRRDHKTQDSAKAIDNMPNVMNPMMMTNMFPQANMMMASGMYPNMMLPGPIMSGGMMPGPGMEIMQGLGGPPMAPAPAPPMEMGMMGGMMMDPSMMGMFSNMSGDIPTMQEKKELIFKHARLTPPDSGTPQPPRRGKPPGCRTIFVGGLPDKIRENIVREIFETYGRIHTLRLSKKNFCHIRFDREECSRDDQNDFERRQRQALRAQQVQMQQMNSQQEIVNRNINPFLDLRRRSPSPPSRVQPYTNASMVQLAEKLKNEEQFAMTLPTLLAWLERGECSKKNANQFYTMIQATNSHIRRLFNEKMQAEEELQNCKERVKNHIASVIEQLEQVAKVFAAASHQRVWDHFTKPQRKNIETWQKMTQEFSSLKEEYLEKFGDDRDGDYNGLSRASESEELQQLKRENESLQFQLEAYKNEIEVVKSDTMKEMEKFKAQFIARQALQVALDKNPPLPSPMVHPQGASLDYVVSYVRALFSQVSQATIHHVLQKHTDVFERTTSGKESLFQKLQVFKSYEANFVTDQYCEQNYELLRVAADGVRAHHKAVLLPTGRFFFLANPNKRGIHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8J0</accession>
    <name>A0A835G8J0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000300">
        <property type="protein sequence ID" value="KAF9409752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="94" mass="10210" checksum="9E3EECCE69411F02" modified="2021-09-29" version="1">MAFKNVWKLAGGGAGWRRSSAHCGNSAAKRCATLIFANNMNSSTIEFVSRIFFACTSTGSILAFSSTSHTQENARRSSPPLNEHKLELSKSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9A7</accession>
    <name>A0A835G9A7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9A7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385:SF0">
        <property type="entry name" value="RE51073P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032985192" description="C2H2-type domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="448" mass="50990" checksum="0A4AF79DB9F93F3C" modified="2021-09-29" version="1">MRTTSFSLEVLALLFLTLIPWPGPSVFKITCSRDNSKIVRKVIENKWLPVLERFQVKLPLECPFHPARDIFAPQHSAKLQHRPSQWTCAFCGKSFYEERHLDTHFDQRHKNQINKAEDAVCLADYCDIMRCQVLVAHGLLSGTGGPSTDIEVWQDVESVKKALAPAATRSVARVSARRRHRTRTAPPPPIEDCPRSEADAREEESEVEEKRTEDNNDSDANQTAELCDADTVESSLPPDSRHKRLADLQAERAACDPTRLQTLKVRCERMVHSCIATLLLHLTQHQFTELEEEMQRAVCWYLSCDRYWEDTAPSARAFPWPLLLALATGLALALCMCYYIIWIVFELPYVQAFLINTMVDHLYLQEAAEDFPEPRSRRSSSEEGSVAGSASVSMTTHSSPTRGERLAAEDAMLDDPDHDDHYIYVTYPPELKRRLLERATKLILGSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9N4</accession>
    <name>A0A835G9N4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009057</name>
        <name evidence="2" type="ORF">HW555_014028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000819">
        <property type="protein sequence ID" value="KAF9405071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000189">
        <property type="protein sequence ID" value="KAF9412454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9N4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="35418" checksum="5DE3D17B6DD8AE3B" modified="2021-09-29" version="1">MGKMASNNFRARKLVHMVVNTDVCHDNSVRNTELSTSTLTIEIEPEDTKKSEDEIFTDRQDIASSQDVVNADFSLNLSSAALGDIRVSDYSFSKDESFGLLCNETLTHSLMGSPVADFGTEDEPTTSQGLQEIENQRSNESCPDVDNAPTTSNNQILVTDSVMQNEDNEAANRLVCDALKGTTKKGTPRIRKLYTESTNTRKEAKKQKKIEKFCVKPACTTSCKKNVERNFQSQTTEHDGELREIGFLKMKHIKSHSIPDPIQNSSPRGITEARKSAIISTLTRVIPENRLPFWQNLHTNDNSIDLVNILDVDDCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAC3</accession>
    <name>A0A835GAC3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAC3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7941" checksum="E2AEA9A451A6CD61" modified="2021-09-29" version="1" fragment="single">SEVSACSSNYNPLKALYSNKVKIPVESAPLYENIAQFEAAQSKSNEVIPFGHNKMSWCLQKSTERETFSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBD7</accession>
    <name>A0A835GBD7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBD7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="21561" checksum="454F2B4D4ABDA53D" modified="2021-09-29" version="1">MNPFECLVDSISTSLLCFHFKTHIPRSFSLAIDSPGLSLASTTCFGANQAILTQPRMVQRSAWMRVLPLLVSISICIENTHSLTHRKCIHARSCGSRDTPGETCTPARSVLNEFHTIFIKTIVMLSTARPMRIEQEPPCVNLQKGNYARECAKNPHDDADIQSRRNARRYVTLDRILDDTEIEQMEVWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBM0</accession>
    <name>A0A835GBM0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein madd-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000218">
        <property type="protein sequence ID" value="KAF9411642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBM0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF313">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="572"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116973" checksum="C356A4AC54CC5FDD" modified="2021-09-29" version="1">MENKSVLDYIGPGLLARVGCDLRVGSTRRVDECGVCGGDGSSCSRPRYHWLATPGSLCSATCGGGYKMSLAVCRDRLTGSDAPEQLCDASSKPQASVVRCNTHPCPFKWYVGEWSSCSVTCGGGVRSRRVLCARSANVTKTDTYEPGTNSEPGCVSPAPRATQPCNQHDCPVWVAGPWSGCSVSCGEGVQVRGVECTPSGGGCDPTTRPEISRPCSTGISCPAYRESDEPEDEIEDLLPGVVYHTQPLIQPYPMPQAKAERLIGDPDVPVEATYIKDDDWGPCSVTCGEGWRKKEVHCKIFLEFSRTIAKLPDSKCLGPKPTEETERCVMEPCSMAYGTSFGDSSVPSYGGNGGDSRLLTFGTSSNIRVAPGSPGKSYSWKEKGYTSCSASCLSGVQELIIQCVRDEDGKNASPYMCDPLTKPENRVRTCNDHPCPPRWNYTEFSQCTKSCGIGIQTREVTRGGTNTVVVPNSMCPQPPPPDRQYCNVLDCPVRWHTGEWSKCSKTCGGGLKQRDVECKQIMAQSHVVERPASLCSSPRPAATKSCNSRPCLLDTASPEISLANSSYIQHDPKKKKVTVKVGGSATIFYGTQVKIKCPVKGYNRTKIQWAKDHQIISKSKKYKISRKGALRINSLSLRDHGVYTCVAGRSSANLTLLVKPRPGEFPSSEEIERHKALDEPSSPLSDSRADGRYRAMIGGTSDDQSHEQRPGDSRKNYKNRQKGKIDKVRDALYGNTATTSTKASPSFNSQERERDLYDEHEGFGNSRGQRTVDSIIMYQNYGVPTKSHFFNLEDKQMVFPEDDDSDIIIVNEDYNRNVLRDVPVENLKDSEETTTEHRLEAPDAHEYVWMTTDWSPCSALCSQTGHQIRGAVCQHKKDNSTTTVETEECLSRGGTPPTVVRECIGDTCAEWRTAPWSAPKCLSSGAAIIRRRVECVAVNGSTLQESACDSVSRPEKIRRDTSLCKATWAVGPWSKCVGTCSSVGRQHRALRCVWRAVGSRRRGKERSAAAACEGLPRPGVTRPCQVHACVNKDGICRDSSRFCENVRAMNMCALKRYRQQCCKTCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBZ0</accession>
    <name>A0A835GBZ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032494930" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="100" mass="10966" checksum="088E2D8F6AA67903" modified="2021-09-29" version="1">MCRLTPILLFLAVSTYVTCSLITDRVTKDIPLPDAELEENNAPEATPIEVPQPNSVTESAGCAKIGEFCINHKDCCTNACLGYMKRCVSAREVEDEEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCA6</accession>
    <name>A0A835GCA6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Arrowhead</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_004509</name>
        <name evidence="17" type="ORF">HW555_007782</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000138">
        <property type="protein sequence ID" value="KAF9414239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000826">
        <property type="protein sequence ID" value="KAH9630376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCA6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09379">
        <property type="entry name" value="LIM2_AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000023">
        <property type="entry name" value="LIM homeobox 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9414239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9630376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24227" checksum="F9EF7C19FFFC5B0B" modified="2021-09-29" version="1">MCLRRSFGAKCSKCCRGISSSDWVRKAREQVYHLACFACDACGRQLSTGEQFALHEDRVLCKPHYLETLDGGSISSDDGCDSEGYHKSKAKRVRTTFTEEQLQVLQANFQLDSNPDGQDLERIAQVTGLSKRVTQVWFQNSRARQKKHQHTGKGKQSQLVSRDADPAGFGRPINLHLTYSFQNKPPFVPIDGTSFTDSSMDELSEDSSIHCMQSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDG6</accession>
    <name>A0A835GDG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000100">
        <property type="entry name" value="Cyclic nucleotide-gated cation channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF4">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="97"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="35781" checksum="2319D0FC186E6E91" modified="2021-09-29" version="1" fragment="single">MKMMTCRLGSRRLGGSRGSLQAGTACSAASELDLSSRSRRAHKARLKLLGASGEAPLLSGWRSTPHTPHAPATPAPHHSHNHLAPGHCNGTDRFAFQEINGETLIVWFCLDYFSDFLYLADILFHFRTGYLEDGVLQTDAAKLRAHYMNSTTFYIDCLCLLPLDFLYLSIGFNSILRSFRLVKIYRFWAFMDRTERHTNYPNLFRSTSLIHYLLVIFHWNGCLYHIIYKNNGFGSKNWVYHDTETADVVKQYLQSYYWCTLALTTIGDLPRPRSKGEYVFVIAQLLFGLMLFATVLGHVANIVTSVSTARKEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDM8</accession>
    <name>A0A835GDM8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="363" mass="39322" checksum="892D437E34A53351" modified="2021-09-29" version="1" fragment="single">MYFENEDWDLPAVIVDSSADDTSCQNCDYAFLIANNPARTFENGPGKSTFEMPSAEELIERRAKELACQQELQRLRELEERGEEAGTDRAAPDSLAADLSALLRRPQARRLAASELWAALAPHVPATPDDSPLLQAGLLEAQMPDIVQALAAAVKSATLWSDADMLASCALLAVAVLMENSPCRRKAVRTLHALLDRYANQEQLTAVANMMMTAFPAESAARLELSDQLCSGACSGGDRVAYILNGTAMLQLLGAGRAGPHCGPSLAQVARAAAAWRQRDAAARLRCVQLAGRLLSSPAGGGASAEERALLLEHLRPEPITASDTPQEDRLKVSYKSLIQSREPPAYLYSCSRRRPWVFGFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEA4</accession>
    <name>A0A835GEA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_001035</name>
        <name evidence="9" type="ORF">HW555_007732</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000810">
        <property type="protein sequence ID" value="KAH9630807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9630807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="44821" checksum="51BB074478483D38" modified="2021-09-29" version="1">MGMISRVRGRIRSDSFSKIHTLKSEDKLANIVWLLSLVLLLPYWAPRGLLVALGGAWLMAAYTCLVVPVLISANYKYPATWYPAVVKLAQELAKKLRSPVSRVMGVMKAAYAPVERAEKLFLQMNNLSTMIGQLLMFTACDRLLVSQGRLTCLYSLMFYNVVTYSVSYVREICTKEDWSPYVNVTRHSRVKHLAMSATKIVLEWTKAVTFIVTITFVLLALGLEQGLEHYKPTALYTVITGTYYLLTERTFLELWPIGLSALKLERLEGMELLYFGAWARAITTMLALPLVPALIWYERWRLSALLFYVCVFVHGRHRLGEALMKLQEARGSLARFRRATAEELATLEDVCAVCLGTMKSARVTPCAHFFHADCLRKCLANSDRCPICVRPYVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEL2</accession>
    <name>A0A835GEL2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEL2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="18607" checksum="BBE090D06BBDC521" modified="2021-09-29" version="1">MGVPHITSFCWCMGLEVGAKCVGFIHLLVSFILMILCSVFAENVRGFVGTAEDAGDGLYATWYKIAVTTAVVTVVHVLLAFTLLFSVFKRKTCGIRAWVWVMSVLCVAALVCILVLVGMHGLSGSGSDIFLSFLEGLVFFGVMAYCILCVNSYYLMLKSAEDMEGPNKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFK2</accession>
    <name>A0A835GFK2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFK2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032531893" description="DUF3456 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="24736" checksum="7E5D3D0D4D6B25B3" modified="2021-09-29" version="1">MIFSIICAYLLFTTQVLCRDDSEINSEEDVGVKYANRCEVCKILATELQERLEQTGKVHDVIEIGYSLDDVQPKKKTKYQKSELRLIESLEGVCEKILEYNIHKERQDSTRFAKGMSQTFKTLHGLVDKGVKVDLGIPLELWDKPSAEITHMKTQCESLLEENEGAVEDWYWNHQGEVDLIKHLCTYNALKGTDDSCLNEQLTTAKGERGSADKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFM8</accession>
    <name>A0A835GFM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000134">
        <property type="protein sequence ID" value="KAF9414413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040057">
        <property type="entry name" value="Spe-39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364">
        <property type="entry name" value="DEFECTIVE SPERMATOGENESIS PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364:SF6">
        <property type="entry name" value="SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 C-terminal" evidence="6">
        <location>
            <begin position="117"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="420" mass="47410" checksum="72B80E9E9563F242" modified="2021-09-29" version="1">MDDDDDYWNTSETKAKAFNFDDDVLSTQEILAIGQKSYSPSGPSEESLFNNISITTVQSAAIPLSSLVSSKVLDLILLAQSGKDPSKETKYEPEQTVAMTLKRLTLGRSCSLHVHRSMKSKTELLDGALAIGDGNAVLTVVLFLIQTLNKKLVYELLSSRPVALNHYIAFLQNEGKISELADLLTMLGRSPEAAMYQYQHTVKTQGNNVDVLLRKLTNLLANHFNQPGVDQHQAKMISDYIKLLEWQKHVNKPDLKYNSVIQWLAYNCTHHWHEGAGNAMSPLTLCQRHQITPLQYDWVVLNVHAKSGKWDIVESLFTKKDWFGRTTISSNIPIETLLSRLSQLQASKQLLATCVNKVANSDDRLRLAHMYKIHAVVIETLAKQKDRSALTNYKMTLNPQSEEYILAENTLRDNSIKWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFT2</accession>
    <name>A0A835GFT2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial transcription termination factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFT2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF6">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38025" checksum="05D027F87AB05C72" modified="2021-09-29" version="1" fragment="single">TVLNKLKPTYLLLSSAFKLSPVFITENYVPLYHRPPYRVINKLSIISVSYATRTKTTEKNGFNATKAKIILALNFQSAEDALPFYKLPVKTLIHVLKVTKNDESKGHCKNRLYYIASRLKVPTSVLSEKLAKRTFIYSLSFDWIEKALNVLLEMNVSSDRILRDLWVLKYHHETIHERLLKVRNMGIENLYPWMVRCSEDILNRYITISTETKDILGETKSKHTYLANRLNVSVETVQEMCFKIPALKTIRVTKVKHFLDFLESEGFDVEEIATKPRVLSASQKTVKKRLDTLRNLGLKEINLNVLCRSKKDFKKYCDSIESISEQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFY8</accession>
    <name>A0A835GFY8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_007466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFY8"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9414688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="426" mass="49026" checksum="257E2D5B0CC69F31" modified="2021-09-29" version="1">MKDTKERTMSGSSTMLSNDYTAAFSSINERPVDDISLEFFYKPHTITLLAVSIASVIYTAFVRDESSIQDNIWSGICCVVFFFLIVSVLTFPNGPFTRPHPAVWRIVFGTSVLYLLALLFLLFQSYSTVYEIMYWIDPNLRNFHIDMDKEYAVNCSDISLTKIWSHVDVFAWGHFLGWLFKAILFRHAGLLWAISIMWEITEIAFAHLLPNFLECWWDSVILDVLVCNGLGIWCGLKICKALEMREYKWVSIRDISSTTGKIKRAILQFTPVQWTPVRWLDPTSTYMRFCALSQLVVFWQISELNTFFLKHIFEMPPSHPLVIARLCLIGVIVAPSVRQYYTYVTDPNCKRVGTQCWVYGAIMVTESMLCIKNGKELFGQAQVCNVIVWLVIQILVSIGCVYGVVLYHRYFEPNNDSNAESPKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGX4</accession>
    <name>A0A835GGX4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGX4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="113" mass="12443" checksum="31E5CB4454AE440F" modified="2021-09-29" version="1">MGKQNKPKIYSNVRYNFKLLNRIYAKIKCFKVALDWWIEAAQAHRCLSTGAGAAVRGLLGSEPCDLPLLRPLVSNMNEAARRFSLFTFLLCAQKNTKVATPVGGATLKGKQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGZ0</accession>
    <name>A0A835GGZ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF32">
        <property type="entry name" value="ARYLALKYLAMINE N-ACETYLTRANSFERASE-LIKE 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53871" checksum="E272A4B894C57659" modified="2021-09-29" version="1" fragment="single">ISYCAVFITLWWCQQTIQNFTETISLQKKNIYIITMSQPLKVLSKFSVTKKDGSVLNLRIVDMPEDMKVVEKVMDCFLNYFVKEECTFKAAGVPESAEAMEELKGSVGHMVTNEKPVFSICCLDNGKDEIDEVMGASLMMYMTREEAEKKLNFETKELQKLIEMSDGLSEIYDDLKEFNLDPYLLDRGIVVCPEYRGLGIAQELLKVRRLISKEFGIPINGAWMTSYGTQKAAERDGWETVCEIQYEDLEKNMPDSNKVWSKFSVTKKDGSVLKLRIMDMPRDPSVQEKVLNINLKHFVLEENTFEAARVAENVEAIEEITGFIINMLNMDNHHIVICCLDNDDQINEGGFKTKELMKLAEIMNALSESYDEVKEFDLNPCFSDRGLVVCPAYRGLGIGQEFLRVRRLICKEFGIPINGAWMTSYGTQKAAERDGWETVCELQYEDLDKKFNILWRICGGFDGALLSLPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH67</accession>
    <name>A0A835GH67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 138</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_007424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM138 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH67"/>
    <dbReference type="OrthoDB" id="189688at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024133">
        <property type="entry name" value="TM_138"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13306">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13306:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14935">
        <property type="entry name" value="TMEM138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9414792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="159" mass="18601" checksum="63B2ABD9EB0C1A99" modified="2021-09-29" version="1">MKLSTPRYTFCLFFQVIFMLCDLLFNCVSLFPRSRDGLLVLFIFQDLFLVLSITTMLMTFFSTYLFQAGLVEVLVRKFRAAGSVCVAYIVASVALHAAWLLEKWAEPESVSTPLLICLFTLQRCLSPWYYFFYKRAALRVSDPRFYEDIDWINQQLQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHA1</accession>
    <name>A0A835GHA1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHA1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="851" mass="95533" checksum="F484D6D0E74EA88D" modified="2021-09-29" version="1">MLISDGINHGKLQSIIVGELKKPGLKHRLKKIILKSVKDHKTVFGAPLVKVPSCSVICCGSTLSVPIVVTEMSSVLRSNAHTEGLFRKAGSQNRQKDIKRLLDAGGCVSEGHHPIDVASVLKLYLRCLPEPLISAEVQDLLLRCRLTAGEDALKPILHTLLLLPVLHVHLLHYIMELLNFLASKHKDNLMDSSNLAIVMAPSIMPLPAAASAQRLEHHVALVKMFIENSQHIGKLTEELMSQLDDDSDGYLARRKKKRRSGSLNRVLSGLRKMVSGSVNTPATVNENGKTPVLSKSAAKRKFDTYEGLSAKTKKEITKNLPQKELSFTPMKMGLERKRLRLSLMDARSTPIINRDFSSHKNSETSVSSEDLLTSSEHLFSAHDTIDLSPDMKQSDKDYVRISKQEYEEIKSRVSAIENRLSREFTDVIPRVQPLQQVQNVYEQTLEEVAMLNCPSSDHLARRLSKELKIRPNEEAKIIRSPSARKIGSIRRRSKENITKIVRHKSWNVSSQSQSSHNTDRFYPYVGLNRRERTSTAKPDLETQKSTTEWDASVSEHSLNNVSDSSQKYRLRKRSSLIMPPDYSSEKPISRIPARRSLNITVNNSWDNTASENSMNNTLNSSGKSNNSDLAQCYQNVTCRNRKPSPPQSQQKWRSAAAFFMDKTGELEKTSDTGRPSVNKLRRQNAGAVLAKAKLFESSSDKSSERQEKVAHTGFARKPRISGTQNKPLKNVALVKPKIQSPIASPNIPVRVTRNIEMPNVPSKSYRLNVPSNEEVNNWRTARKTTPPVKNVVSPRSMLMKTPQIPVLKKPLCTPKSSRLPALNNDLRKANTPMKAVHISPRRRSPRQKQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHX5</accession>
    <name>A0A835GHX5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032849361" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125063" checksum="FA93513F551C9AF8" modified="2021-09-29" version="1">MLRLEVYLLSLCLLLSSSNLLSPEAEALKITRRNTGQESENDNLDTKHINTMYNTIEIFEEYTQFLRNNQDLPKHNNYLDKVEYILTSLKKGLLRHTLTATCQTEGNIQKFNKVIQDVMDILPPLVQEKEPELSPELKEAKGLYDAALLTLNRRTPDLYRVVYRVRLPRDIIEYILAKMKLAWSYLTREGLEWELEMILADLHGAMHQVTQAANIGYVPAKIKLAWSYLFGENVEMDLEKAKDLFEELAADGNAEGHAGLGFLYATGIAVPVSQAKALLHYTMGALGDSDFAQMALAYRYWSGNTVRMSCPKAMDLYMRVASKVISYVEGAGPGNIDSEIIDSDTTSTVEYYRRIAEKRYQEKQAQPDYERDLLYFKEAAKLDNPAAQVGLGLMYLKGRGVPKDPEAAFKYFTMAANQGWVEGQLQLGLMYFNGIGVRRDFEQANKYFSLASQMGHVLALYHLGLMHAQGLGVTHSCVDAVMLFRNVSERGPWATRMIDAHESVYPRGVDSAILQHLELAERGYSSQQSIAAVLLDTSNHRLSKGPELKALYQQLRTRSKVPRQEQSVHPYNSELLGPEARKKSEKNEEEDEESESSDTKFNSVDADYFKQLKDAMKKEEIVLQEYADAIRNSRDIPKDEEHKETHLDQMEYTLKLLKKSLLRHTESAWITDPKSTETLEGDIEKLEENPQDILDTLPPLPEEVEPELSPELKEAKELYDAAMVKLNRRSPDLRGAILQVKQAADMGYVPAKIKLAWSYLFGEGVELDLEKAKKIFEELAVEGNADAHAGMGFLYATGIAVPVSQAKALVHYTMGALGDSDFAQMALAYRYWSGNTVPSSCPKAMDLYMKVASKVASQVTFSGGPAIQRTRLIDEAEGGGPGTLDTDLIEYYQLLAEKGDVQAQVGLGQLHFQGGRGVTLDINKALHYFQQAAKTGNAVANAFLGKIYLEGGDGIKADNDTALRYFRKAAELNNPVGQSGLGIMYLQGRGVPKDTNAAFKYFTMAANQGWVEGQLHLGFMYFGGIGVRRDFKQANKYFSLASQTGHVLALYHLGQMHAQGLGVLRSCTTAVELFKNVCERGPWGARLMLAHAGWRARDSDSALLQYLALAERGLEIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIY9</accession>
    <name>A0A835GIY9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="181"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="510" mass="55622" checksum="36B8CEC63E1BFB52" modified="2021-09-29" version="1">MSDPEFKLYSNVFIETNIQCVDYDAVILILYPEDLSVPLPRHIGSFIEKISKVDKHIHKAATVWNCDYVSGGRLVLSPTGKISPYHDAKVVRDAAFKGMTRALEAGAKKPLLVVQNVVNFPDGQLVCILGALEALYVPLQTRERDAPNNFLRIGFHSDEILTDRFEKTVRNALALEKSRILTRDIAGSDPERMTPANIVNYVKSSFKADSNITIKIIDDQETIAEEYPLLAAVARASSQIERHKPRVVELEYKPSDITRVTQTLLLVGKGVTYDTGGADLKISGKMAGMCRDKSGAAAVAGFLKACSILKPPHLKVKGVLCLCRNSIGEDSYVPDELLISKSGKTVRVTNTDAEGRFAMADALFKMGVLAENELNPHLYTIATLTGHARLCYGNYTAALDNHSARGTNHATALQFSGSRVGEGFEVSFIRPEDLAVNNGKCKGEDLVQVDMEAKCRHHQLAGGFLIKVGGLEDKNIKYTHLDIAGAAGTSPSEPTAVPILSLCHVHKVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJD9</accession>
    <name>A0A835GJD9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJD9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="229" mass="26301" checksum="6EF7F6FE583D6DD3" modified="2021-09-29" version="1">MPIVVAVAMDPLQVILARYFNIWNFVCAIRDEETAVAAAKAWLLIPARTPRCPICRGNMSREPKLSYKLKYRLRCWRCAREGRPSIRSPLKNTFFERSHVSVLDTVRLMLHFLRKDKVSQAAIDVGKIPPGPFGCLSRLTNKIHVELIPDKSRTTLDPIVEANVRTGTYLMSDMHRAYDNIHLRLGMRGHSSVNHCENFVGGPSIFRLTIRWEYRPQVVMSELKFTLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJV3</accession>
    <name>A0A835GJV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="869"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1328"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1356"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1509"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1561"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1598"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1625"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1169"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1701" mass="190045" checksum="2D539E323B712FCA" modified="2021-09-29" version="1">MMIALIYMGDNSSLDDAVLITPGVFGPGSSPALAVARRWCTVALARGPLTSNPRTRASTMSNEEKGESHTHKPVDLDNILVEEVGQFGKYQIVTLLLAAFPVIFSAFASGEYIFTTARIPTRCLIPECDGENPEFSPEWLSNAIPASGSGFSWCTEFERSNVTVDVVEGTCPAALFNPPREMECQKHIYQNQLSVVYDFGMACDEWKRSQIGSIRTIGTLLVLPITGYISDRWGRRVALTINAFNTGWIGLVRSFVNSYEWFLALEVLESSVGAGAYSSCYILVTELVGPKYRVIAGATISTLFALGQVILGFIAWGVPAWRPLTQVLYAPQLLVVSYFWILSESVRWLMSKGRYEESEQILKKVAKTNNKELSDKSLEALRATAEAEKNTVKPKEPWLVVLVFRSRVILSRCLVSPIWWITNTLVYYGMNINSVNMSGNGYLNYVAVAAIEIPGYWTAILLLDRIGRKPVLICAYWLCAACQFSFAFMPEGNEGIQLALYLFGKYCIAIVMTSVYVYTAELYPTKYRHNLFAFSSMVGRLGSITAPLTPSLATEVWGPFPSVLFGSFALLSGLLIFTTPETLGTKLPDTIEDAEQLGKKTTTYLCLDADHLVGSCALPCVCSVLLAKVSMAGPVSPTRRMDLDALLVEELGQFGRYQLRTFLLAAVLVMLVAWSNLEYIFSTARISTRCLIPECEDEPTEFAPPWLVNAVPAGSTQGSFDNCERFGNFSASRRQLDSDICPSELFDQGTRLPCDTFVYENTNTVVFDVRQGDNNIVRYGLACDEWRRSLIGTVTTFSTLTALPITGYISDRWGRRVALTINAFNTAWLGLTRYWADTYLAFVLSQFAEATFGCGLYSMTELVGPDYRVAVGAALKTCFALGQVTLGLLAWAVPNWRNLTLVIYTPQLLTILYYWLISESVRWYMSKGRFDKSEALLKKVAKANRRQLSDKSLQALRHTAEERLQSELKVEGSSGDEPWLVVQVFRHKPILVRCVVSPVWWITTTFIYYGLSLNAVNMSGNKYLNFIAVAAVEIPGFWTAYYLMGTIGRKPVLTGAFWLCAVCQVAYIFIPQGMYAAALSVYLIAKFAIAMVATSVYVYTAELYPTKYRHSLFAFSSMIGRIGSMLAPLTPAFGAQWFAELPFVMFGFVDLDTILVEEIGQFGKFQLRTLLLTVIVVIFAAFHAECLIPECDGEQPEFTPAWLSKAVPTTEDSFDNCHRFGNTTALPRADTCPAELFDRNKVLRCDQYVYQNQLSVVYDYDLACDEWRRSLIGFVRTFGTLTALPITGYISDRWGRRVALSINAFNTGWIGVTRYWADTYLGFMISEFVEATFGAGVFSCIYILVLELVGPKYRVIAGAILNTFFAVGQVIMGLIAWAVPAWRPLTLALYIPQLFTIAYFWIVPESVRWYMSKSRYEESEALLKEVARMNKKLLSEKSLQALRDSAELKKQSEAQRKEQNIREPWLVVKVFQHKRVLFRCFVSPLWWISMTLIYYGLSINAVNMSGNVYVNYMAVSAAEIPGFWIAVLLMPIIGRKPVLIAGFWLCATCQVAYMLMPSDMFGLSLTVYLIGKSSISAVVTSLYMYTAELYPTECRHNLFAFSSMVGRIGSITAPLTPAIGAATFYNLPFIMFAVLAFTSGFLVLLTPETLGTKLPDTLEQANNLGTSKQQNYSLVLYAGYYFDFLNLITISGLTRQYSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJW1</accession>
    <name>A0A835GJW1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000053">
        <property type="protein sequence ID" value="KAF9418573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJW1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="18192" checksum="295453BFB4599BD6" modified="2021-09-29" version="1">MLGTDVISISRSVIADVRRGVVETADNEECPKHPKFLWKPFLRQFYVCTVCTSIYFVLGLCFGAPTVYIPQLRKEMQANATGSQLTDDMASWLYSIFMTVIKKLVVSFHSRILLYALGDNPTNTHALHRKENSVSYCNCNDTSQLHRVLLQYQPRALVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK57</accession>
    <name>A0A835GK57_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">cAMP-dependent protein kinase type II-alpha regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004907</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK57"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12086">
        <property type="entry name" value="DD_cGKI-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="232" mass="26924" checksum="A7F5C663DA0FF035" modified="2021-09-29" version="1">MAQTHTKQCQMDHNYKLEKKYLEMKRMVLEKTEELKRRDKIIALLEHEIDEKDGTIRYLKNEIDKFRQVVKPLTRQLIDNRRNGLESEEDCFVMKTPGIENTRVYHVGEPRLKRTAISAEPLSSLSQGYEMKLVKIPKVQKSRELIKSAILDNDFMKNLEMTQIREIVDCMYPVEYAAGSLIIKEGDVGSIVYVMEGTSDNYFIKLLLPKLIFGYTATGLILRDDETPSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL73</accession>
    <name>A0A835GL73_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL73"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="442" mass="48393" checksum="91A5FAAF28D84A20" modified="2021-09-29" version="1">MGSIVRRNIRHPILLLGGDWCLMSPVVVEITTLRVITGQWIAVQSSPFSGDPGERYPGAGGGTGAAAGSLAWCSQLVSSSNRRKAQGRCGATLVCCLQAAGVVCGAGRGRHLCGALNRYKCSEVQISCCEWFEKKNYTHTKIISQVKRSDLYSSNYHKNAIYDDVEELGLEHLDKEDSRHKQLKHPQPKGTQSFHVVCKHRHHSLLHPVGASGSNIGEDRSTVHKELSSIASTSAKDDIKNCIAVVTAQAEGSSKPMVNRQGVRSKHLTTQELDEALEVCIKKSQEEGFAKELEELRKNEICEKGSLKSLNIFLDSKGIIRVGGRLEMAQLNYNRIHPILIPKESFLTNLLVAEAHAKTMHGGPQTMLTLNFIVHGGRCRRTLCNMSLVGDKCSPKHYFELLNKCATDATASLLGRRLVPLHICVHVTADDRGALGTASVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL85</accession>
    <name>A0A835GL85_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004841</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL85"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF413">
        <property type="entry name" value="CYTOCHROME P450 18A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59651" checksum="D73606523F53933E" modified="2021-09-29" version="1">MFYYYFLVFLAINFLSSAFLRTFMYSTLVFWIIFKNIKYYKSLPPGPWGIPLLGILPFLNRRPPHMVYLNMAEKYGDVFSVQMGSNLTVCLGSTKLMKEFFSRNDSTGRPNTPLNNLLGGLGVITSEGVLWKRQRVFLHEKFRALGVKLWPNTRFERDINVEIDELMVELNQSEGKSVNPAHVLGRHIHNVICQLMMSFRFTAEDSAFKLFNEKVSRGMRLFGLVLIGEHVKAYLKLPGKMAVINEIKKNLADVSDFHKERIVARIQQREQSSEPRQPVDLLDFYLDHLEAEKQSKATKNEKRDIFPDVDPVQQIVQIMNDLFSAGMETSLTSLLWTCIMMMKHPKVAEKVRADLREVVLPGERVTMGHRLQLPYIEAVLIETMRMVSIVPLGTTHVNTAEWKIGKYTIPAGTHIVPLIHRMNMDPDIYMEPELFKPERFIRDGKFTITDTFMQFGVGQRMCIGNLLARMELFLFFANIMNNYEFCMPEGEDIPGMDGILGSTHAPLPFKLVFKKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL91</accession>
    <name>A0A835GL91_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL91"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="13443" checksum="D73695F2A62D103D" modified="2021-09-29" version="1">MYTDFDGWVTRFNSYYKRSPNYSSESRTISRQKDSRRHHDENELYDRDYFLNNLLLRQRHLRRSARRPCFNFYKENDGFMSYDHVYYRLVNKNGDKRIVYQYIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMH5</accession>
    <name>A0A835GMH5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMH5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF209">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="701" mass="79594" checksum="BA163D55C04D6CE8" modified="2021-09-29" version="1">MTTIVTLAQYSHGGFESGAIFLYRGVTGAAPPYHRHADSPPDEMIVLIIIACITTAAATNSTKDATTESPTNTTKEILKASETADPKKVQIVKQIRRLNEDGSYTIGYEADDGTFKIENKDVLGNVKGTFGYIDQDGEIKRVTYTSSSDSTPVPVTTSTTPGTPTMIVRVNKTVSSTTRRPLPTVVYPTRGSYTTRGTVIQPIPRRRAHASSTRAPFTETTTESQKIEETTTNILSLYKPKVEEVKTRTQILKPMSATVKDDLITRQTTTKIPATVKPVYERVTEKDQESDANKANTIRRELSGTSPNPRMISLQQSVGDDSTDVYGSHLSMGTVRPLFTTTTPRPRLVPIHSLVAARQKIQQQYQDVPIQDQETTIEASTGRVFDQDHVLTTNAVPVVHIQPQRDPNEQVYQQPIYRRPPAAIHFRTREYLRDNPGAPVPIGNTRPFIQYEFQNKVLEPQYLKETSQHPQRPQQTAEVTPNPYDPRPVTRIIPIPVDDRGVPLQGYQGRFVNPYQRPALFQPRYEPVDEMTSIAAPVSTRDLRRLLHILILRQNKLQALMDQMMPGPSLYRPESEYRYQRYQDDDRYDYRYDQYRQEYQGQGYETQYESQRYVPRRRYPRPYDTAGSSSNHIEEMPEYLPPEIREALLLKMLILAISPDFMPTVAPPTELTTAAPPRKQVRNIQILGEEGSMDDKRQQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMV6</accession>
    <name>A0A835GMV6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMV6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="385" mass="44529" checksum="AF01FAA5C9571369" modified="2021-09-29" version="1" fragment="single">PSRGLAQTNYKIISNKLGGRTLLHVGFAYNLHRKNNKSSVWTCVNKRHGKCSGSIKLSEESDNVQIQKCHNAECQPNLMKNEVRVVMEKLKKEVKTSFSSSIQQIFETKFAELKNTDTAFDEYIPKFNNIKQQLYNSRKKALNVEKTQFRNPAEVIIPEIFQKYLLVDYCENDNRIIRYRPAVTIHGCNVHFQRAIYRKAKSLGLLAHEETTLYVKLCTCLAFLPKEDIEDGWLSVMENSIPDEKVTQFNDYFVEQWLEPPGMISKWCCYKERHRTTNLVEAWNQRLQCYQGRKPSLLSFLEIITTDISTYSTDYEEMTVLCKRKKSSIINDKLIAKLTDKYEKKPITIMEFLEQIRPTKTKSGASTTGAKHTGGVTYGPQLFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN04</accession>
    <name>A0A835GN04_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN04"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="355" mass="41039" checksum="4EF18ABA1202E298" modified="2021-09-29" version="1">MSRALLLLNKMDSELYTNITHRKPFRASSLEDLSNLENMDNEEKTIFDSTMMSIPDSLHDNSNIIIELSEQVKALKMQLKDAHLEIENLNSENFRLKSDLQNMTIKTDKETQTCDTNNIQTTNSLKTAQNISPSFKNNLPKHTGNLTSTIVKHQQKNKLCILSSHKSRGALSIIEDVFSKYFDFCHYVFPNGTVKELLYGIENKLRNFTLNDYCIILIGENDIKENKNYITTINMIKEAFQKVTHTNNIICCPTYVRGAPIHNFRVEMFNNLINLSIQDNEYAYLFDSNYGLSLDMFSYITGKINNQGIRNIYERIMENILIDINTFNKFDIDTNIIPDETTNSPQNETDTQFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNB4</accession>
    <name>A0A835GNB4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNB4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000271">
        <property type="entry name" value="Monocarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000372">
        <property type="entry name" value="Monocarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="760" mass="81310" checksum="3C46009881D56360" modified="2021-09-29" version="1">MTTESETSCEEAARLTAEGAAADADDDEAYDYGALPPPPDGGYGWVVVFASFMCNMIVDGIAYTFGIFLPELVTYFGEGKGTVAWVGSLLSGFYLAAGPVVSALCNKFGCRAVCVAGSFVAAAAFVLSTFSKSVTMMMITYGLIGGLGFGMIYLPSVVAVGYYFESRRSLATGIAVCGSGVGTFSFAPLAALLLNEFGSWQNANLLLAGLILNCAVFGALMRPLVYPKTSGEKPLLQRMAEEKRLQMERGSIGGSYFVVQLPDGTMEKRLKVNVVDDTAPLNIDPGVHSSLNLEALARVPTVPNMPGVPTVPTLPTITEAKVADDGEEKKKGENGNVTVNPQQQLMSRNVSSPAFSAHAPGLPKNGSVPFFDRQRKQSTGDRFKPSLAAIKATSKTSMNSQYRNADGDTESMMYNSKLSVSGPKEPSRMVRPMSRKDIFYSGSVLNLPQYQSQKSLQGYRNSVLSLPQSRQTGDLERQEQYDLCPCLSLPDSFKSALSSMLDVSLLRDPAFMLIGVSNIFGMAGLYVPFVYIVDAARLSGVEPSQASFLLSIIGITNTIGRIACGWVADFPWMDSLLLNNVCLVIATISVGLTPFCTTYATYVAIAIAFGIAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGAAAMIGSPLAGAVYDATKNYDASFYMAAAFFLASTLTSFAAPLFRRKQEEVQQPMDVLTPIDEDLEEGEEEDEDDTPITMGAALAQRPPAIVRTAASPSDPPSPDQPTPQRESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNH9</accession>
    <name>A0A835GNH9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNH9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124376" checksum="CEC6071543C3C759" modified="2021-09-29" version="1">MSIVLLARVMGHVSSDVTYDTMWEYLAVLLLGFWLGVAIFLYISCYWLEEILDLPAPRNASPAPSGHSASGAHVQLKRLVARVVEEAAALPALARYAAEPHTPSIESSTYEDLLATAILNKVIERYQNENGSGGRSSGIHSASASPTPSERSSPRSLHSRHNRNVTPPLREEDDVSDWEEGDATDEALEVPRRVPFPEFGGDIVHNTDNEDREFDEVSSSDLQAVDGTWEENWLFQKKKIKTIQSVPVPMLVPNSNTEYRALIGDRDADDTTDLSDNASDSEEQAEYKSDIKKVLDSKHVIGGKPKVEECDFEPDSLTIIDGVDDDFDKLVEKMDDDDTVEAIINEINDNKVTIVETNNVNTVDQVDGGKLLVSIESGPLTKAEFAVKEEIHRTLLNGNAEEFMDDLSVKTNGDILHNGHAEVNSLDSFTNNKESTNTLSHHEREGEYEETVTVPVQRYADSLRRKHFDDGPQEIPTRDTDQDDLIPGSIAYRERKKWLNYVDMPNNPYSPEAIQKRLSAKNTSSLFDMFTAKKESDDENIEINDNEADEGDTGTNDLPVKDNQHNKLSLTMSNDSINSIGRTTKSPSPRILKDVMAEEIPQYKRYGRDYYIREAKASCGGRKKTSVDEASTVSSASMNKSTSLDNFDAEFASPVSASSSLSDLEASALHHNIVRNVLSPRNASPNFAINPIFENPDRHNDNADENHATDERYVGQNANVRQQCRTVCDGDGYVENEDIVRLKIPKIPEITEDLFETYTHVRRSNTLRSEDLCVRAKRRPALNFTFGGSLSTTVILKDGLLIKQFHTIATNQHYTKFANKEDMASVTTSTNNKHEIMIEYDDDASEHTLFAAKPVYVEDDTDKQFEEILETASKVPKEPPPPVPTAHNEDPTDEPLKSPLSVDTSYISTSSMEDSIKIYNVQTGEIIKCKPDNVSPSYEADTNDNTDIVDNNISETDTVSYTDDVTEDSPVEDTKLSKLELIESDDILQNLPKVKELAKIFVSMENVAEPVKPVQPYSARRKSKENILSESKPEKTKQQYMHSLTARSISKEFREELKLSMSTPLTVPGGSKEIPEGIEEVTKESSRPGSPVPEPGTIKTKLAFFESLKSKFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNQ6</accession>
    <name>A0A835GNQ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNQ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="102" mass="11186" checksum="D0BEEFC7BDE0AD6B" modified="2021-09-29" version="1" fragment="single">RYIDALKVVLNNAPVGSANQQIKDNALALTLKVLLAIKSTQIEEAVGNLCLDDIDILMKYIYRGFECPTEGSSGHLLLWHEKAFNIGGSGSIVRVLSDRMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP05</accession>
    <name>A0A835GP05_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF97">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="332" mass="38602" checksum="8024FE3EFBDA7EB0" modified="2021-09-29" version="1">MAARKQQSERWRKLRNIVQWTPFFQTYKKQRYPWIQLAGHQGNFKAGPDQGTILKKLCPQEERCFKILMKDVLRPFVPEYKGQVTCEDGELYLQLQDLLSDFDSPCVMDCKIGVRTYLEEELAKAKEKTKLRKDMYEKMIQIDPKAPTEEEHRSKGVTKPRYMIWRETISSTATLGFRIDGVKKADGTSSKDFKTTKTREQIVEAFKDFTSNFPNAAPKYLERLRSIRDTLKESSFFRSHELIGSSLLFVHDKRRASIWMIDFAKTVPVPDNVNIDHDSVWKVGNHEDGYLIGLNNLISIFESLSKDDNGNIDQCYSDVSLEKNVRKDSFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ13</accession>
    <name>A0A835GQ13_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ13"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032558997" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="149" mass="16198" checksum="720925DC58216FE9" modified="2021-09-29" version="1">MSKFTCIILCVVAASLTKVSHAVTEEEKEAFREAMAPIIAECSEEHGVSEADIKAAKEAASADGIKPCFLGCVMKKIEVLDSKGLYDAETGLGKLKKFVKDEDEFAKFEDIAKKCLKVNDESVSDGEAGCDRAKLVLGCFLEHKVEMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ92</accession>
    <name>A0A835GQ92_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ92"/>
    <dbReference type="SMR" id="A0A835GQ92"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06685">
        <property type="entry name" value="PDZ7_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="210"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="374"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="609"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="925"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113607" checksum="83ED32A3A96B1E7E" modified="2021-09-29" version="1">MFDQIFILKFSLFAGRSEPGIVPSIVGFTKDSVAHESDRLAPGDRICSVNGISTARLTNDEVLRLLDNVEERASLEVEYYMPNYASQNSLYITTKLAEVPVEKINGSLGITIRGGLPENSAPSADLVLNSRSLDAQPLVVTHVRPGGAAYNTSRIKPGDRLLKVDHVSLTNKTLSEVHNILQNCPQVTSLTIEYDVSIMESVKLATGPLLIEIERPCNEDLGLFLTNQRCSDDVYSSGSDTYQRVGTCNAIYIDSILPASISDRCGALHPGDQILAFDDHVIDGNNYTAEEVMCYLENCEGGFTRLHVAPRHVVGHCGRFTRENSISGTSTLNAKKHRQRNYRQSSMPKLGLQDDYDSQQNYMSMGVCRTESLNIQLEVPPGQSSGLAVHEENAMLIISHVASQSPAYRSGCLQIRDRVMSINGHENLTVDVANEILQRRNDSHNPKYLTLNVEFSMPNTIEASSGVFNVKLAKTTAGLGVTITDTTLSNMAAQPGCVSQTDVHNACHGCKQKLLSNEEPMDTAFNILQNSPEDIITLKIRKRDLTEDWSNIHKHNAKLTLQSFSNIEIKAVVHSGEDSGHHTDSPNNSAKESERSHGSNDNGNTAVFTVELIKQENGPLGLTIAGSEDVTQPILLSGLVEGGVAEKCGKLAIGDELLTINGESVLNKPLSEAIKLLQQSGQRVQLQLCRKVTGSLESAESSARDSSHSTSSPGLSNDSAVESWDQNTPVRTSANCGNSEVIEYAVPDKTRMMDKQPYSPTDEDKLMASNFNSAAPYSINDLPLPNYSLNNSLKTFHYENTCIIPENSLKNKQNITREDDVQQIEILTTNMKDCQLHNMERSSCKCDYVQMGPYGIVSPKTRRPNWDSDYLNNGIYTVTTPQKSPLKPGVPGTSFQFSTSPIYENEVPGLYSTEAVSPARGSVHHVILYKDAIYDDYGFSVSDGLYERGVYINRIRKGGPADIVGLLRPYDRILQVNGTRTVDYDCCLTVPLIASAGDRLEIVVQRLVTSRELRNQQRADDSSSPSDSSIVTKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ93</accession>
    <name>A0A835GQ93_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="345"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="650" mass="74363" checksum="42D0070589F6407A" modified="2021-09-29" version="1">MRFEPACLSLDIRHGARHAGVLGAQGARQPPQELLLRSHATLQLRFTSFKLFLHLIIHLSLVQKYHAVLENKQSDASTWKMKEAAWESIQNEFNARSGGIFRSTKTLKVKYEGLKRTVRKKSAACRSELYRTGGGKNTAPPLDNVEEQIKAMITLSADGLESIFDSDVLPQNQEDTIDVPKMEEFLRIPPLQMDTTEVVESEATQNQVVLLVTNEFEPLPPTTSAETVLETNILKVDNVNDKALHETPNGRCGTTPTTSANKKWDVTSRRNLKSRKHPALIANVPKKTLFDELTQAKLELVQLQKDFLEAEINEKKKVWEFEENERKKEAEFKEKERKWKEEESANFSLHEREILVSLVQKYHAVLENKQSDASTWKMKEAAWESIQNEFNARSGGIFRSTKTLKVKYEGLKRTVRKKSAACRSELYRTGGGKNTAPPLDNVEEQIKAMITLSADGLESIFDSDVLPQNQEDTIDVPKMEEFLRIPPLQMDTTEVVESEATQNQVVLLVTNEFEPLPPTTSAETVLETNILKVDNVNDKALHETPNGRCGTTPTTSANKKWDVTSRRNLKSRKHPALIANVPKKTLFDELTQAKLELVQLQKDFLEAEINEKKKVWEFEENERKKEAEFKEKERKWKEEEYLQIKIRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQT7</accession>
    <name>A0A835GQT7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="396" mass="43945" checksum="45F39D120B02FD91" modified="2021-09-29" version="1">MAEKSNESSPSEPASTPRQEDKPSGNWWDTWISSAKSKSAEVYTMVKKDLDEIGTAVKSEASHVFSTTSTVIGKTLKLDVPESPANVMKKSLSSFIGQVSTVLNPEPDDDDDTEVILSSGDTTMLSTYKKELEALQRVDATFIVPAYSAEFEAWRGSLESSEAGLISLHAAAKRLDASPTLKAQYEKLVPDAVSHDDFWERYLFRVALLQDRLAAASRKQPQEEPSTDPVLAHLPMQAPAPVVQSPKKVLSGLEDEKPFEAPEMDNVVAWEDEDFAHDVELTEEQQTLLLEEYEREIASKKTKQTCTRDIANNNTDKTTSTDNKKTKTAQTRDKMNNKTANKNGRSPKKAPKADVCGNNLVEDYFGDKEVKDDASANSDESWEKEFEIDDVVEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRI7</accession>
    <name>A0A835GRI7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRI7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000008">
        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047163">
        <property type="entry name" value="ASPP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131:SF10">
        <property type="entry name" value="ANKYRIN-REPEAT, SH3-DOMAIN, AND PROLINE-RICH-REGION CONTAINING PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24131">
        <property type="entry name" value="APOPTOSIS-STIMULATING OF P53 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="839"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="908" mass="99847" checksum="CEB0BA950F5D01A8" modified="2021-09-29" version="1">MVYRNKLNEQQNGRLSAQRAALGARQEEMRSIDRRVSELQARLLRKRALNRQLAAAHRQPQQQRTSNPPPMQQLPSYSAGNNVVNSQPKNQQARGNVAAVEPYNHVPHAQSVSHNANFQAMKQNVLQNNVPLKQHTQSDNIQSHLTQEAHYLQQKQMINPLFNGYTHSQGLQENQYPGQYPNKHENFSHVQQGIGNAYDQKAMLDQKQYMDYLKQPQYSPNSTSSSNSNQTNKDLKINEQEFLPEFAASKSDPKYQTLPYNTKFPQSTNGKLKPEVNGKNNENQDAKNAINVNHMTVHSTPLSVVNKSLATPLSQTETTYQQENTYQLQKSDSSSRCNQEGKENQAYPQNRLSQNNSQNNEASKGNGKGQQVLKGSSPSLGSSTTSASSSIGFGKPVSSVAPTSVQVSSGKPSPIYQTSSTKIQPVQPQTVQTQSITVSSSNHVASNVVTSQPQIVRNTASGLSTSTGSSFTGQNASSQSILLSPPQSASTPLSTPDVSGTDKSPKPALPPKPTIKTPPRQSVNTEVGFNQSTDNITPMPTIPLPSDLSNDSDQQNQKDTVSSTSSNEMIIKARPLTIRKPPMSEQPKLRNVNNTKNGISVSINRRIEMPPAFLFPEMDHLVDSTPNENGLKDKKQKDEVDRALNNNNISIGQDDSKDIVVSDITEQISSVDLNGQDSQGTENVLRRKKGNLKQGGKAPLARRVSFDPLALLLDASLEGELELVKKTATQVQNASAANDEGITALHNAICAGHFEIVKFLVELGCDVNAQDSDGWTPLHCAASCNNLAMVRFLVDNGACIFATTLSDHETAAEKCEEDEEGFDGCSEYLYSVQEKLGIMNNGLVYAVFSYSAARNDELSFETGARLQVLRKGDDNEREWWWCRDDQATEGYVPRNLLGLYPRVTTQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRT6</accession>
    <name>A0A835GRT6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRT6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="111" mass="12694" checksum="7D5B2E6794F38F63" modified="2021-09-29" version="1">MATITQTVQEFLPKNQIEQILPPKTKGIQQKSKQEPQALGCPEDCPCKMNVQKPQKRPLQLLFNLIGIIVALVATYLIVTTDSNMYLIFWICYSVLRRLTKSKSRSRVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS03</accession>
    <name>A0A835GS03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF95">
        <property type="entry name" value="LD37241P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="6">
        <location>
            <begin position="508"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="583" mass="63229" checksum="6D652F06CE324AC2" modified="2021-09-29" version="1">MVMGCGRIFNALRRCKQLEDGDNSTQLDRCLGLLDLTALGVGSTLGLGVYVLAGAVAKTVAGPAVCISFLVAAVASAFAGVCYAEFAARVPKAGSAYVYSYVSVGEFIAFTIGWNLILEYVIGTASVAKGMALYIDSLCNNSMARAMTEAAPINISFMADYPDFFAFALVMLITVLLGIGVKESTKLNNVFTALNLITVIVVVIAGAVKSNPANWRIPLEDIPDEYKSQAGAGGFAPWGVAGIMAGAAKCFFGFVGFDCVATTGEEAKNPRETSHCLLCCLWCIATVLTMMLPYYLQDADAPFPHVFTEANLPVIKWIVTIGAIFALCTSLLGAMFPLPRVLYAMGSDGVLFRPLAAINKRTQTPVMATILSGLLAAIMAALFNLNQLIDMMSIGTLLAYTIVATSVLILRYEEESTIQLHATKPAPETPFSVFKQLFNLLGLKYPTQLSYVIAKCTIMIFFVVALATCALLRWEQAEAALGVLGAALLVLLVVLYRQPRNNVENLSFTVPLVPLVPYLSVCMNVYLMVQLDYQTWVRFIIWLAIGYMIYFFYGIRNSSLNVKNEPQTNGVIEEKRQVVTTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSM5</accession>
    <name>A0A835GSM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF312">
        <property type="entry name" value="KARMOISIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="39"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="51170" checksum="1611829CAEF3D2B9" modified="2021-09-29" version="1">MDTEPKESSDLLKARNTVETNGKLKSEDLKDPPDGGVRAYSVMVASFLTNGLFFGVINSYSVIYTVLENHLKNEGISNSESRAALVGALTMGTTFFLSPLSGVLTGVLGIRLTAVLGGTIATAALLLSSFFVYNVGVLYFTYGIMYGLGASFAYTPSLAILGHYFKKHLGLVNGVVTVGSSIFTVIMPPLMEYMILHHGLDWLLRLLAVFTLGTAVCGFIFKPAPSMVTKASREDDSWKSLLKSIVNIQIWKNKKYRFWALSMPVALFGYFVPYVHIKKFIENNFVDVNTNLPLQCIAVTSGLGRLIFGFLADKPGVDRILLQQISFYVIGVLTIILPFVNKFGILVAIALGMGIFDGAFIALIGPIAFELCGGAYAAQAIGCMLGLAAAPLSVGPPIAGYIYSINKSYTLPFVLAGISPLVGATLMFAIRLQRVPSNEESINTNGIAVRPVSVRIEKSPSLLLSNGDANQQTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GST1</accession>
    <name>A0A835GST1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GST1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015395">
        <property type="entry name" value="C-myb_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09316">
        <property type="entry name" value="Cmyb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="805" mass="90045" checksum="1A44A72EAFBD3A1B" modified="2021-09-29" version="1">MFEERSGYDSETSEYSEDSAAAYEDVQAATKSSGPRKNINRGRWTKEEDKKLKACVNIYNENWDLISAQFADRSDVQCQQRWTKVVNPELVKGPWTKEEDEKVMELVAKYGPKKWTLIARHLKGRIGKQCRERWHNHLNPSIKKTAWTEHEDRVIYQAHKQLGNQWAKIAKLLPGRTDNAIKNHWNSTMRRKYEPDLLDSFETLRRKNPRVKPRELVESNIMQEKVQVAYNDQSWSDPFNESAQSNSSNTSQPPSKHVLHFRQLLKDQLNNLQHQVIPKSPDRGGLVAADEMEIVDTPFKFVNIETLPTDSPLRNYLSSASTGTESNQDTVTYSIQAEASKEIEVPSAMYTSPRKKAVETSTPPPILRRKTKKIPATSSNNANAWTESLSKALEYRESGVTPIKALPFSPSQFLNSPAGISFSAIDANSTPLRHAAKEWSASPLLQTPTPVNHVTPGGPNPVKSNTPKTPTPFKIAMAELGKKSGLKYEPSSPGLLVEDITMMMKRENSDSTVQLNDSLLSTAADQENGNVQINDSGIGSLKRGSEAGKENVPGHKKARKALAPAWAALTSTPHAREHTPTLVPDVSYIETPSKTLAGDSSVMFSPPSIVKHSLLEESTSLHSLISAENTPDTSKYEDIDIEAVITEKTKVQHRSLLLTNPEPNTLGPTDIIYPFRDITNLDNPSFSRLNADRLRTITTGNELACDTLIAPKQVLANALADHIYKIARGNEPIVVKKSAVRSIKFDRLEEPVEVKEEKNQSPFIVGTYKWQTFACGMTKDQLDLTQLAHQYMRKTALKPRSLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTH6</accession>
    <name>A0A835GTH6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="4">
        <location>
            <begin position="338"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52298" checksum="DCA79CE0B35C031E" modified="2021-09-29" version="1">MTPVNAMPEDKELIRKRASFKGKVTVFVNYLNTLEPDSLSPTESAVGTGLSLSASVEQGDVLLATALVKIMGINGTRFRPLSLDTPKPLFPIAGFPLIQHHIEACAKLEECKEILIIGSYTTNTMAQFVNDMQKEYHVMIRYLQEFTPLGTGGGLYHFRDQVRAGNPSAFFLLNGDVCADFPLKELWHFHSEKANALVTIMGTEATRQQSVHYGCMVRESSTKSVTHYVEKPNSYVSTLINCGVYVCSLQVFHTMADSFQKKQDGFYSGNGQSSPHPGYMSFEQDVLMQLAGTNKLYAMQVTNWWSQVKTAGSAIYANRHYLELHRDRVSKDKPCTVLPDVFIHPTAVVDSTAVIGPNVSIGAGVTIKAGVRIKESIVLNNATIHEHALVMYSVVGQEASVGEWSRVEGTPSDPDPNKPFAKMDNTPLFNTDGRLNPSITILGAGVVVPAETILLNSIVLPHKHLTRSFKHEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTL1</accession>
    <name>A0A835GTL1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-dependent mannose-6-phosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_005526</name>
        <name evidence="8" type="ORF">HW555_000648</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000196">
        <property type="protein sequence ID" value="KAH9642196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032314668" description="Cation-dependent mannose-6-phosphate receptor" evidence="7">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9642196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30608" checksum="6796501FF2209D3C" modified="2021-09-29" version="1">MGYFKVFSFIVIYLTCILSVINADQCEMRAPCVCVFSNGTGIDLTPAISTEFYTASTYTVKMNGSQYEMSTYYYHPCYDVNLNVSQSLPKNTCTLPLSICRHVSTMNLVNVTTNTYTFDQGSYDFMGRTNISNFSDQGNSIKYPNGPSETIVLLECAETENKLQVYSLSEPDKIVLAFYSKDACLKQIEVNGRSFGSTLLIIFFSMVVFYLVLGICTKKFLMGATGVEVIPNLAFWSDLPNLVKDGWRFMCNGFKLPPRGAGPAVSPDPNSYDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KW71</accession>
    <name>A0A835KW71_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000935">
        <property type="protein sequence ID" value="KAF9404600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KW71"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="838"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="902"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="261"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="375"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="7">
        <location>
            <begin position="449"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9404600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1266" mass="136560" checksum="0207AA8BA9FB4F4E" modified="2021-09-29" version="1">MILTVAYLQVQSPVLVVELNLDRIEGTQLRALGLLAVYGFNVTYEVRAAAQAPGPTSCSAIECRLLGHCYASHDYQEFYCSCFDGYSGADCGVGPLCPTTSNMCKNGGTCRQMGPAAVSCICAPGYTGDLCEAQVAPPECGIEECAEVCKDGTACDCNPKDTDALSARFETRLQVVGLPNENISDEIAKQLTQFLKASNITLEDDVQVLNTSVTTTEGIRDAWVRVWSSRREAPALRAALARLASARTRLLPTSTHFEMHPALSLHIVILFNLQKLVVNQRPEVWEGSEFILTCMAYGSPNMAFTWYKDSVKINFNGTTRDIWTRTVSEDALGRRMSVLGVTEAERLDSGKWSCAADDAGRRRCRALRLTVLRPPEIRLVPSTLTVNRGDNVTITCLAGAGRVHGALGFSWARERTLLPMAPGREVWEDLFPAGSVLKLYNVQKSSEFRCQVSSVAGTNAKAVTMWALGSGDAACESDASHGLRWPKTAPGAHATASCPPGHSGETTRFCEPKTGDHGVKWRLPDFSGCVADSLRDIYEQFTLISMGYSWGSVSHVSRQYGAVLRSLPTHPGEGELPLTHAVHMLNYLMSPAAQPHDRYNSLRSSFNKRYHEFTVMSKPVLEDNAAHFDLQPALAEREEWAVTSAGVELVTKTENASVVTALYHDLGARSGRATQYTIASQQIQLSVSGAGVDNTLLHTVTLLFTHSKNYSAIGPQLACGSRSRSSPRVWSTHTCELRVQEQTYIACRCRGLATIALFTVDSLGLTDAESDSRAIVKITVSLGSAMCLVAALLQLLSLVVGSKTRLPVLLRAATAATHSAAMLTLLECDTKQTSACVGPLGWAVAACWCAGCAALCAQPLLLHTELAATATRAPSVGLLAGVSTLCWLTARLWGGAPLQLGAAANAVCGAGAALLAALTFCLALCAARTLRTVTQKLPPDRREYVRERARVVRHTLVLLFTTTATQIAGVAYAQPGERTILKVVALSVAALANGLAMLICYVVCDEECLRAARRLLTLSSNNEWHDSPEGDTSLSLYIRQGREMECRGAVGSLECSSSHVSPANTYWRATPLQSPLHRRGSSGACVADIVRCVEYKQALLPPRNVHTRTLCDLIPIGGAEPRVSRVCVELGVLPEASQTTVTDASTFQPSSDTSDISKANCTLCAKSTPDVSATSTAPRPIKSCLKKRSPQLSWSTSLPSINHESDESNSHLQLVDTQSQTPSTHTTFTQTDKVLHKISHDLDFLLNRTPSRVADNCPQQIEEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXY8</accession>
    <name>A0A835KXY8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate carboxyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000867">
        <property type="protein sequence ID" value="KAF9404852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008985">
        <property type="entry name" value="PRK12331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="435" mass="48575" checksum="477F93DF4E74A662" modified="2021-09-29" version="1">MLPIIQTMDEAGFHALEMWGGATFDACIRFLDEDPWERLRAIRKVVKNTKLQMLLRGQNLLGYKNYADDVVEAFVQKSIENGIDSIRIFDALNDTRNLQTAITATKKFGGHCQPAISYTTSEFHTIDYFVDLTTELEKMGADSICIKDMAGILTPDDAFRLVSEIKHNTQVPLEIHTHATSGIAEMTYLKAVEAGVDIIDTAISSFSGGTSQPATESMALALENLGYNTHLDMKKVAEIADYFNPIRDTFRAKGMLNPKVKDTEPKTLIYKVPGGMLSNLLSQLTEQGLADKYEEVLKEVPKVRADVGYPPLVTPLSQMVGTQAVMNVISGERYKMVPKEIKDYVKGLYGKPPVAISEEIRQLIIGDEEVITVRPADLLTPELPKYEAEIKDYAKSTEDVLMYALFPQQGKDFLGRREDRFYDVPVQEVSVTLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ11</accession>
    <name>A0A835KZ11_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_011249</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000323">
        <property type="protein sequence ID" value="KAF9409355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032573358" description="dolichyl-phosphate-mannose--protein mannosyltransferase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="19">
        <location>
            <begin position="274"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9409355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1570" mass="181261" checksum="B42E6324D8AF1A3A" modified="2021-09-29" version="1">MPAKFIAVVSLSCLPFLFTLDGDFVFDDSEAIVKNEDVTSDSWTELFTNDFWGAKIKSNLSHKSYRPLTVLSFKLNYFLNNRTLSAYQFKVTNLVCHVICCLLVWKVFQTLTSRKVLSVVISENERLSRDLESNKYWWRNTAFLATLLFTVHPVHVEAVCGAVGRADILAAITFFLAILCYSKSQARHSRGYFFLLCTVFLAGISMLFKENGITVLGFCIIYEIVTKLKINRIESRTAKILSLDNITVDSMFRVMAIFTSILSLMYARWAVMGNTKPEFKPTDNPAAFAPTAFAKVATHNYIYFLNLLLFVWPQWLCYDWSMGCIRLLENMSDSRIVLVYTMYLYGLYTLETMYSGRNMKITNRIMFLAISLVVLPFLPAANILYPVGFVIAERILYIPSAGYCLLVAVGFNKLLDRRSTKFRKIALFSFMSVVMLYGVWSWRRSLDWQSEYSLFISGMAVCPLNAKVHYNVAKIADANKQYDMAISEYKEAIRLYPQYYQAMNNLANLLKNRKQYTEAERYLRLAVKNREDFPAAWMNLGILLASTKRLKESEAAYKTALNHRKNYPDCYYNLGNLYLEMNKTEAAIESWLQAINQSPKHVLAWTNLLALMDNTGQIDRALEIIPKALSELPNAPAVNFAIANMYGKLSRYEDAETHFLKAIRLFDKDIKAIHYANLGVLYHRWKKYALAEEMYTKALKIDPSFKTAQKNLVSLQKRNEEKVRSIIESMTRFLKNEKYINESGVIDTMVSKTRKFAMYIVLNSDLKAVKEMVEMEGVFLVVQSIPNIPQYLMSEMLWNLCMENFVYEIITYGYPPLAVEVAGAFAQNYKYYNPTKGLQKLHNLSAAIYSLICRLHCFDFDKETFKKLLTTSYETLHKCLKYFSEPPNSHLIDLLINDELYKFHGNCFKTILLLIYECFSCFTQEVNSSWFNDIYRSTYKEGCFKCNPPTNKVCDCPNKDVTECLNNCNVMLLDIFQEVVMGVSIDIFCAWSEFEDDGKSMQQIIGELCHKVRTKLLQVNSVAEHPVIDMVQQMARKPAVISDIINVTDANIIIQNINSNCADRSSWIHALVHKELLCQHIDLIHIIESNLNEFDDDECLQLYHMFTNYAKSNTTNREIVTSVSIKIFRHCRVSDKHKLLKEHFNDNQFYDMSDDEEFHTLLTEMFNKFVADTDADFKEVLNVFLLNPKQVFNKIFVLAEENAQLTNTMLKVMDLLRDYSNYYYVTETEPCIISIIKKILDESLDSDNKQDNIVQFLSGLKKNDLIPGTKLLLLIIMPHMHKALLNKDIGKIHVQIQLLNEAYTIQELLEYRAPMLAMLSQVLEVVRWGNIKAFVPKASSTLQVTLNFQKSLIETYDSVIPNDEGDWLRIRLKRKNMQPQNNFYFRKLLGGQGSNFFQAVSGMQVDKDTNRSEISIWVTQILSSGTQDEWCMVWDNLTRHIEDIDVLCIFHEALRMIAKAVEGTRTPATRSCLFYCIQNLAYVIRYKFFQVPLTDRHVISAAFSLSKLLKDTNIEDIDEIGSRLMPLFAYLVEKKNNYTTNVPSYFKNTFYATLVNRAFNGDSGQDDTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZF4</accession>
    <name>A0A835KZF4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000745">
        <property type="protein sequence ID" value="KAF9405416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12253" checksum="F8300FB79F54CA53" modified="2021-09-29" version="1">MYSGCRFDVRGKHLSEARHWSAPEVFGPRAHFSTSPPPAALLVRDVKRRDEGVYRCRVDFRNTQTTSFRYNLTVVVPPEKPVVVDRWGRVINTTTLGPHEEGDDEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZJ1</accession>
    <name>A0A835KZJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-dimethyl-L-lysine(36) demethylase</fullName>
            <ecNumber evidence="3">1.14.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_013718</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000705">
        <property type="protein sequence ID" value="KAF9405639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15554">
        <property type="entry name" value="PHD_PHF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="203"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9405639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="649" mass="73995" checksum="F52E8D6B096CE399" modified="2021-09-29" version="1" fragment="single">MASSKETYCLCGQPYNIGQFMIECDCCREWFHGSCVDVKIYHSDDIDKYHCPKCAQTYGPSVLKIPTNNHRADRYELGAETRPSQVGTPAWVRALAARPLRPAPAALQRMSPHQFTEEFIRDNGFTRPVTFTTSDGLDMKTPNPGTFTVRSVLRYCGAQLEVEVIDVRKQSTLRMPLGDFVDYFETPPEHRDEKVLNVLSLEFSETNMARVVEPPAVAVSLDWAERVWGGARERPPAPHVRKYCLMSPAGAYTDFHVDFGGTTVWYHVLHGRKIFYLIPPTATNLALYQQWSAANNQNERFFGDMVEWYGTAEVTAGQTLFIPSGWIHAVLTPCDSLVFGGNFLHSYAIEMQLQIYEIERRVETPTMFRYPLFEAMHWYAGAHLLTMLRRYNEEIQDEEFTLSETNPRQTPAALPPLLLRGIKILANALKEWHALKSTDTAKRDNVPKCLNSGQLVRELCKELRTLEKRSTTTASKDKDFKVKNQSSPTKSHSKKSQSSSKKSLKLTLPKPIMHMGQNGEFVEEKNYNDKFYIDNKVRGCISERYVTQDGKYGNGVPDTKYVVEGKEMVMPDKGYAYQTYEEVSYPDNNGYVDRPDKKTTLKIKMNHEEQFAASLQVVLRGFSVMQAMVDDVVTFTRLAWQDGEFPGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZM5</accession>
    <name>A0A835KZM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NF-X1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000377">
        <property type="protein sequence ID" value="KAF9408541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1433"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1518"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1612"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1665"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1785"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="6">
        <location>
            <begin position="1861"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2201" mass="254519" checksum="8A3CA974852947F8" modified="2021-09-29" version="1">MEHGHAQIWTTWELSIDLKRKRNYRYLFGEYGWWRSTSVWCESEERLNSHRQYDCAHICTELPNGEYSKKDWFGKPTSNNKIKFDKFVKKLEMPFVIYADFEAFLNPIESCSNDPSQPSSFGYYIKCSYDNRLSKYETYSGSNCAQVFMNRLCEDVKTIVKKNSFQNAPFHYQMKIKLKFQIQTYVIFVKLSHYDAHFIVHALNFDDDKVEVIPQNKERYISFSKQLTINNQPKRGPSQRPRRNSQRNSKNHNQNIRRSTFSISELSWPTGNRQNQPIYQHNSHRVQQTNANPQGQKNHGQMKRDHSSNRLRLQHHDLQQEPDLRTFVKKDRLRDNNPRSGRATQKKRTMGFIGLQKIAESEEKDVLQKINEHREDFFCIVNAPIEKHDVFVLVVEILSKATQSPFVELKSKLMLDVFNTVFINHLRYYLVDLPYDENKSSNNLYWRNQIQFWKNLLTFCSDIVDTSPAIAINRCKGLIAVMKTCLESLHDNHGLVLSEDCTIKFNEIRQKMTSYENRYQSALTGKKEENTCQDLQPPDDFRNLSLVPTVEDLFGSHPFLRPNIVEGRYEDVKHYLDVQFRLLREDCFGPVRDGINPNKTKYDHIRLFHNTRFLCPYVDNLRVGSLIQMDMKRYKHLRKINWKNSKRFLFGSLVLFTKDNFNTFLAATILHRDADLLSSGKLPVSIVDVNLDDSVYNGEMYTMIESEVYFECYYHVMKSLQECSFPQHLPMQKYIVEVSFVIPYEEISPVSRSNENNIEIVTNEESDKQITKKTFDVLQPNTWPTMEELNLNESQYEAYRLALTQEFAVIQGPPGTGKTFIGLKVAKTLLNNIQADGQCLMLVICYTNHALDQFLEAISHVTKSLVRIGGQSRNKAIDQFNLATLRRTSFSPSAFPSHKYFIEQRNQVRRSMIELQSALKTVDVMNNGLLSYNYLLGDIPALQVLDAYYKGQGMELEDPLEFWLFEPVLTFNPDYYRNLEDCLLDYKTSVDTEEELDNRRERLDFDDENLGSDLCEQEEASFLLSNAKSKIKNLVSNYYSTQNVHERNLIVNTILNLDARINLFNEMVTNRDRDVVIHINDRTIFSRITVQNRWCLYFTWTRPKVIEIKEKVVNLQAALSPALAAYEEARMMMDVQLLKTRRIKVVGMTTSGGARMRKLLKTIAPKIVIVEEAAEVLEQHIITSLTKYCQHLILIGDHQQLRPSASHVKLAKRYNIEVSLFERMITNGMHSRRLNVQHRMRPEIAALISPHIYKDLTNHPSVETFKNVPGLEKNVYFFTHDYREQVSNEGNSRENRKEGDMALALANYLMNQGFSSEDITILAAYSGQKFYMKKERQKYASLSRVKIIVVDNYQGEESRIIILSLVRNNPDNQIGFLGIENRVSTLEDFEKLPPEGGCYEKCNFIYPCGHKCQFYCHGYDRQHVETKCTMKVCEVGHVCPLKCSQECAPCKILVMKTLPCGHEMRVLCHRDPEDPLNRCLTQIDVVLPDCQHKAKIDCYKDISKVKCMEPCKYRLEKCGHVCGRKCHVIDDPKHETYVCKKPCARAKEGCTAKLMGDRGLHQCQKKCYETCDGCTVTVNKKRSTCKHAEVVPCNVDIDKSPCPKKCARTMTCGHHCLKICFEECGDCNQMVWKEIPDCRHKVKVRCTISVSRDVCTETCNRVLSCGHPCTDRCAVPCDITKCTAITATEVPSPCGHNVKLPQLRALPARRPARALRAALPPGQHLRSHVTHAISTTHTHITSAGYKFRRGALHAALPPGQHLRTHQAISSVAAPCTQRCHQDNICGHTCQEPCNQICPPCKMPCEVKCAHSMCMKLCSEPCTPCEVEACGRRCVHGRCTRRCGEECERAACLERCPLRLPCGHMCRGLCGEPCPDICQICRPEQFPTDFLGDSYGDNDKFILLEDCGHVLEIDDMDSLMLGDQENIKIRTCPFCRKPIINTKRYKDIVNKRFKEDINPIKLRVYGRNEIISAKITELHGKMEKYKKHTFDTKELNTTFESLKKLVKNQEKVSLVQVEMECIFLNIFELIVDCWQRHLKQTTTFKEEMNEYMNILLNAISIKPSKPPKMPVKISEQQQKDIGNEIKRMNAITHFSKLWDASQHLKNEPEVKQQIELTKSIVFSIFVFSEDDAIASLKKLQDIVNVRLEITKYERKLISLFAALLNCRTLWTDETVWTAKDEIDSSQHFISVCHIIFSSPLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZW5</accession>
    <name>A0A835KZW5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000351">
        <property type="protein sequence ID" value="KAF9408956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZW5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="6">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="383" mass="43222" checksum="EB23FA25E8BFF7E8" modified="2021-09-29" version="1" fragment="single">FTSKVTKCEPTNEPLVEYGKTFQFEGYQVTLENTILFPAGGGQPHDVGRLNDTEVVQVLRKGDEALHFTREPIEVGTVVEQEINWDRRFDHMQQHSGQHLLSAILEKEHNLPTTSWWLGLDESYVELDSTKVSEEVIKATEKRCNQLIQEAIPVTAHTRGLPKDCMETIRIICMGNIDENMCCGTHVTNLSQLQSIKLTGTEPGKKGKTNLKFLVGNRVLRTFQLMLDREKALTGLLKNEPTRHEDLVQKLQKNLKITNKNLQTVLQELAQFEIEKIKSATPKPKFVIMFKKEATPEFNRAVIKGLEGEGLFLFFASEEPDKPKEGQIIIQGPEEHCNALGTKITELLKGKGAFKNGKFQGKAGDLSGMNKCKKLIEDYFNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1C7</accession>
    <name>A0A835L1C7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine-5'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000179">
        <property type="protein sequence ID" value="KAF9412749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1C7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27780" checksum="241489619109DA4C" modified="2021-09-29" version="1">MRVYLLKSVSRVIGARFYSTPNYKKVTHCIFDMDGLLLDTELVYKKMITQLCANYGHKYTDELMMKVLGGTEQRLSEILCKELKLPITPTEFRDQLLVLGDTMLAGAPLLDGAERLIRHLHATKVPFALATSSSARSVDTKIAQYKELFSYFHHMVMGSTDKEVKFGKPHPDIFLVAASRFPDKPHPSKCLVFEDSPHGVTAGMKAGMQTVMVPDPHLDKKLTTHATIVLPSLAKFQPELFGLPPFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1H9</accession>
    <name>A0A835L1H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">VPS26 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000356">
        <property type="protein sequence ID" value="KAF9408869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="439" mass="50185" checksum="567A6F6161A0D6DB" modified="2021-09-29" version="1">MSFFGFGQTADIEIVFDDADKRKVAEVKTDEGKKEKLLLYYDGETVSGRVNVTLRKPGSKLEHQGIKVELIGQIELFYDRGNHHEFISLVKELARPGDLLQHTSYPFEFANVEKPYEVYTGANVRLRYFLRATIVRRLTDVVKEVDIAVHTLCSYPDLLNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEISIIKRETTGSGPNTFTENETVAKYEIMDGAPVRGESIPIRVFLAGYDLTPTMRDINNKFSVRYYLNLVLMDTEDRRYFKQQEVTLWRKSDKSRLPLHNAHVPQTLSHPSQQMPRQLSASSEDNSNRAISPNNPNINNMQRSVSLSMNDGEKQNGPSEMEQEQPDVITNKMSNTHIENNQADEEIDDDSAPILEKQTISEKPPLAEKPQVSEKPVLAEKPVLNRPESEASPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1V1</accession>
    <name>A0A835L1V1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="43572" checksum="BB33BA4D42ACB60F" modified="2021-09-29" version="1">MQRVGLYNSKLKQVTTSSTLRWTNLKKESMSNYVVGAESDQGPIYLCRARHEGDMILGQLKPDYTSCAVSGSKSYNLFEVLENIENASLINWIPGLGFTPNQVVEMKAPSGFSHYIGRIAYENVIGQLITFDDKNNEIIENSGEILKEIEPVSYKLENVVLDRDTEHVRQSEPEVFEERILKNEDEVAATVTTEIEYGYNYTLSWDYGHGIAIGLNTTIELDDGTLFPQIQWANPYTESRPKLLYKLEKHLEPGTACNVTFRGNLTNRDVQYTATLVTYYKDNDSRSRQMRGQRIENTLEVEAIYGEIYFLANNTLENDVAAMKKPDHPEQMDSSDINESGEGMTKGSVPKEDIKKSVVGGLGSNPSGSASMKIVTFTLFIPAIILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L240</accession>
    <name>A0A835L240_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L240"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="161" mass="17333" checksum="2B63F9A7A50A2509" modified="2021-09-29" version="1">MSGVRAARARRARLCRWRAAGARKKASRQMRDAARRTAPPSRGACRAPRSRSARHISQNTSIIAWCVSPLRLGLGEVVSSARPACAGAGGAWRARGAGGARASARAPVARRQAGGSRRPALSHCTAATLRSRTRDKVRDAAPHRTLHMLHITLEHFSFITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L257</accession>
    <name>A0A835L257_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000226">
        <property type="protein sequence ID" value="KAF9411403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L257"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033033982" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="72"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="29042" checksum="0DAD59EBC44EFE26" modified="2021-09-29" version="1" fragment="single">MQIILLTFLLIKSSICSEIMDPRSQDKKYLSEFCPWQKYCKEGTHVVCMYYDHEHEFGPRCGNAVRTEITPKMIQSILQHVNNMRGKISSGLERGKDNKLLPRAYGMMKMKWDEELATLAKVLANQCMGGREDTCRATEKFPNPSQSIAIVHFKYPNWDLPDLNLKYYLKLIRGGATHIGCGISAYSKYKVDGQTESIQNSVQVVCNISEGPQSGEPVYNTDPPIPGQGLTKRCGCPKGYKETRNCLCERVSDEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2C3</accession>
    <name>A0A835L2C3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000682">
        <property type="protein sequence ID" value="KAF9405791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="69980" checksum="450C446AAF305369" modified="2021-09-29" version="1" fragment="single">MKQAQWVDFNTRHTLLSQEIEDKNINYFMDDIYGKTKIMYENTKADMVKLLQAAEENVKFDLSDLSAGEADEKTKTLLTQQECNFKAIDRAMGKIDFDNVSEKWELDDYLAILKSKWERIDSTHWELEALLKGSKNSYNEMFNSMEAKYDEARKLLKSKMWSTAHHQQSAPKIEIPEFSGHYNKWISFKDLFLETIHKNPTLNKAQKMQHLKTKLKGEAERLVQHLSISADNYSSCWAILTQRYDNRRLQFSSFMNTMLQLPVIHKPDAYNLKKLHDVTTECLNGLTNIGFDITSWDPMIVHLMAQKLDCGTFNEYIKSLQDNREVPTLQEFLTFLENQFTAFETMKSSKKESQSAEKAAGTEKHASRNYEHKKWQLKTYHTSYGQCPLCKNNHVLMRCPQFIDSDTKQRNSIVAKLRLCKNCLFRHENETCNSVKTCKECNMNHHTLLHYNKSHNKIANSTSTENQRSGQRPSKETGTASSNHLSANNMEVLLTTVQVKVMTVDGTYINLRALVDQGSQVNLITENAAQLLRLPRNKLTAKISGVGSVSGDLRSLLQGNDSPSLTKTIRIVAWIRRFLGNARNSTKRDTVCLSFCELSNAEELIIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2C5</accession>
    <name>A0A835L2C5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000275">
        <property type="protein sequence ID" value="KAF9410167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="943"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="93"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="292"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="398"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="511"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="606"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="700"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="127112" checksum="43AD5844A7B3CB89" modified="2021-09-29" version="1" fragment="single">PPYWQIEPSDTAVLLNGSLTVSCEARGHPHLLYTGPSSTETTLGGVSDPVVLTNGSLRLESARAEHSGKYRCRADNGVSPPLSKTLTIHINEPARFETQSANVTAKLGDTVRLACVARGDSPLATAWSHSGRALPNSDYRMSISETRSAEGLRSELVIERADRRDSGVYRCQASNPYGRSDHFVHLAVQEPPEPPANFRVLETTSRSFWATWYNIASMIPPALILGGMQKLIMCPYPRMHRKSYAETESATITGLEPATAYLVRARTVTAQFASAHTRALLALTLHEPPSRAPISLRASAPRSSTIELAWQAPPSSSWNGELLGYTVWWWPSADGTLGGGSNVGMEFATVRGQITKYIIEGLEHYTRYSVSVRAFNSAGAGPATAPVNTLTQEMPSEGPRAVRCRAVSPQSIKVEWSPPPAHAHHGALLGYKLLYRPEHTTEWLEWDARGNGGSNVGAGAEVKRVAGVETLLLALRPHTNYTVQALAYTAAGDGVPAHPIHCTTQQDVPGSPAAVKVVATSVTSLAVSWLPPSRPNGPLLYYTVFYRELGRDRPPITTTVQVEEGDPFVGLGGSTELRSLSEGATYEAWVAAHSIAGEGEPSPPQPATTTSRARARLLSFGVWARVQCGHSLRLACAWRGEPAPRARWLRGDRPVTHDPRTHLTPHGHLAIHEVDASTSGNYTCSARNTFGSEEGGVRRTPAAPTLTLDHAAHTDTRLTWRTTHHPAAPPHGFTIWWIRVRDDTGDGLESISSRAEEERRLETGGEASSVVLRALSCGATYSVRAVAHSRAGSSPPSVPLLVKTKPPVLVWEGGGEDRLEEGAEAAVWSNSSALALDARRAVRCGARLVRLQWRRADAAGAAAWRDADLTSLHHHREVVIGGLASGAWYALRLWTATDSARHQAVIYAATTTHSGERLRRPVAFQSEGGQVMTSNNNADTERVLGAVSLAFAALAGLAVTALLLVLVAKRSTLWPCGGTPDEETRRCSHSVASTDKSVCPEQQNIRNCQHDYKHDKLSPASDVYEISPYATFAVGGEAAAAATLDHTLQFRTFGHRDNDAPPHRPCRKHPQRHRERAEVEKHHSECELQQLSRYEKVRPRHCAPTSYCVPLAHHEFLKHFLNKSSLIGAIISLRSVKSMTVTVYTNRLPICDTSAIRSGKCFILTNLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2D9</accession>
    <name>A0A835L2D9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_012689</name>
        <name evidence="4" type="ORF">HW555_009540</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000214">
        <property type="protein sequence ID" value="KAF9411749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000622">
        <property type="protein sequence ID" value="KAH9634227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2D9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF79">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9634227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="17170" checksum="6E1814098010BC7F" modified="2021-09-29" version="1">MADEDHYDDVDISDVIDESDHYLEADHQHAELEATDSEHINTIQDSELLSSEEQITEGKKLPQHNKSEAIRSTRLPIARIKNIMKMDPDVSVVSGDAVFLVTKATELFLETIAKETYAYTATNKRKIIAKKDLDLVINKVDCLCFLEGAMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2E6</accession>
    <name>A0A835L2E6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2E6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF54">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="319"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="611" mass="70662" checksum="2594827BED57D472" modified="2021-09-29" version="1">MATKYFENFNADAYEATYKRSRRMVLNHGDYRPSNLMHKILEDGSVDIKVVDLQTLQGGSPVTDLIYFIFSGSDENFRAQYFDKLLDHYYSELSAAMKRLQLNPDEVFSREDFDYEINEKLPFGLTLATFILPVVTVEMENAPQVDESLDISSFNVEKTSDLYAERLNGVVNDYSAPLHANQYAELCQPVIKFYLNIKMEDCKQSFKDLLHTIAKEQKFVDYSLDIKEISSGGANYTSKLFSVTVTEGTNTLRLFCKVAAIGEKMRAQLDKIYTTEHFFYTKLAKMYRNIEDQCGVPDELKLNLSKYYGSIIQLNEEAMVLEDLVAAGYETYDRFKSIDWPYAQAAVRELAKFHSCAWAYAKKEPEEFEEILKKLSFDIGFEGPEMQAYTTRVIDKAVQTVREENKEIFQKYFESFDAEAYAATQKRSRRLVLNHGDFRPSNLMHKILDTMQGGSPVSDLIFFIFSGSDEKFRAQYFDKLLDHYYSELSAAMKRLHLNPDETFSREDFNYEINEMIQGKLQLRFVHTCKTQFLFIKKISIAHHADFLLQKLPFGLSLATFLIPVVTVDTEKAPQVDESLDITSFNMEKTNDLYTERLNGVVNDYVKWGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2F8</accession>
    <name>A0A835L2F8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="10085" checksum="8CC272B31F005389" modified="2021-09-29" version="1" fragment="single">MLWFNSLEVRRSYFLMIMSCKTLRGESDCPEIVGQVNVRHANYPLVRVLTMLNSLLMSAPDCDLFAMRWIDLCRECLRYCKRMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3M1</accession>
    <name>A0A835L3M1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3M1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="323" mass="36272" checksum="2639D9B51979F5C1" modified="2021-09-29" version="1">MNPLKTALAQVTALNAARETHVNNAPVLCAGEQIVNRDETFCEDMGERALMSDELFLSSIRGLNIQQRNLFQKVSFAIENDLHGQESQLLLFITGGAVKGHWCFLQPSWFSAEINLWHQFSFCELTINMRQRDDTEFIELLNSLRVGELTTAQLELLCERRHVPLNGEFANGVAVRIFPTVRQVDDYNDKMSTENAKLHRTYQINAVDESREVATYGRKPPDNVIPKDVNNCGGFLCSIKIGVGSRVMLRRNIAVSEGLVNGAMGIIKKIKWPALRRDQLEEGELPEAVYIKFDDDTIAVRLKDRDGCIPIPPSTVSQLIGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3N6</accession>
    <name>A0A835L3N6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000443">
        <property type="protein sequence ID" value="KAF9407707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3N6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT DAPIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038:SF1">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01821">
        <property type="entry name" value="DAPIT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="53" mass="5810" checksum="A0A6FA444B50D3E9" modified="2021-09-29" version="1">MAGDSSVDESQLKGLAKYFNSQTNKGRANTAKATYAFMGAMILYFTLKPKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4E2</accession>
    <name>A0A835L4E2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000362">
        <property type="protein sequence ID" value="KAF9408767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4E2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="22582" checksum="1A757054C69FBA2C" modified="2021-09-29" version="1">MEQQKRKRGENWSCDEKEILRQLIAQSAQILEDKSTKSSVNSQKIKEWKNIQVKFNELTGKFRSGGELKLAWKRMKLSAKSNLSMHRREQHLTGGGEKPPSPSPEDLAVMAIAPHDFVIEVNEYDSDALDPVPVPTINAAGIDSKPGPSFETVSFHIETCEDRPEKDFVCLQDTNNSEACVEEQATIKKKKSLQNRCKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4T0</accession>
    <name>A0A835L4T0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_015142</name>
        <name evidence="1" type="ORF">HW555_007015</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000625">
        <property type="protein sequence ID" value="KAH9633938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4T0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038775">
        <property type="entry name" value="SPMIP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35263">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35263:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22593">
        <property type="entry name" value="SPMIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9633938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17959" checksum="2592FE824C44B9F9" modified="2021-09-29" version="1">MEFFGITMYGPQNYMHDVMMEQYQEPMCKENVDPLMEKIKQYSTLPETIQRPDADVIRFIDVYMGRVNGFAYGSMERFVRMKRKGVIKPTYPCDMYRFPPTTSLEIGWWLHDPALMKSDWYVTNPRYPQPTSPNSLILDKVRKNNKYATLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4U5</accession>
    <name>A0A835L4U5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7027 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4U5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054291">
        <property type="entry name" value="DUF7027"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF10">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22954">
        <property type="entry name" value="DUF7027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7027" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="79" mass="8838" checksum="131F2A4EC1C037A8" modified="2021-09-29" version="1" fragment="single">VSGVQIAYFAIIGTQMFMIVLSIFLFYGIYKENVAFLVPWVVGCMTFMALEAMAMVYSNILRDHVNKNTKCECGDNLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L547</accession>
    <name>A0A835L547_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_005825</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L547"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000098">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1001"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1142"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="261"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="848"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9416997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1173" mass="132099" checksum="BBEFDF5177DE3C92" modified="2021-09-29" version="1">MVSNKMQSSLDDLVQYTQLFKPVPTVLQGTVLPFLIIYPIVFYSWIVVYGFEENVEAGFVSVAVVAAIQILVCLCCYWSVHIQCFLSCSSVKDPIQAEIVKVVPTSNNGFSEIVKLHHTKSTKKGSIHPDVWFIFQKSKYIYDWDKKSFHTIEFPINKTYEEYMESKGYLDDEAIDIAEKEFGKNEMIMVVPEFMELFKERATAPFFVFQVFCVALWCLDKYWYYSIFTLVMLVMFECTLVQQQLRNMAEIRKMGNKPYNINVYRNRRWRQIMSDQLLPGDVVSLIRSTNDNLVPCDIVLLRGSCIVDESMLTGESVPQMKEAVDNEKNLKQQLDPEGEGKLHMLFGGTKIVQHSSPNKNTSSALKAPDNGCIGYVIRNGFNTSQGKLLRTILFGVKRVTANNLETFGFILFLLIFAIAAAAYVWIKGCEDPERNRYKLFLECTLILTSVVPPELPIELSLAVNTSLLSLSKLAVFCTEPFRIPFAGKVEICCFDKTGTLTSDNLVVEGVAGIEDHKDATVIPLSQAPMETIQVLASCHSLVQLDDGVVGDPLEKATLKAAEWNLTKGDAVVPKKGKSPGLKIVHRNHFSSALKRMSVIAGYQVNERGFMETHYISSVKGAPETVKTMLKEVPSHYDHVYLTLSRRGARVLALGYRNLGKLSSQQIRDMSREDIESDLTFVGFVIISCPLKSDSKKAISEIVNASHSVVMITGDNPLTACHVAKELKFTQKEEVLILTETESKWGWKSIDEEVNLPVNPFKTSKQLTSKFDLCITGEGLTFLNENHHKFLLELMPHIKVFARFAPKQKEFVVVTLKSLGYVTLMCGDGTNDVGALKHADVGVAILANAPERPREKPREERALEEAPRRNTSRADARAEAAARLRRAMRELEEEDMQLVRLGDASVAAPFTSRLSSIFCICHIIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLDGIKFSDTQATLQSLLLASCFLFISRSKPLKQLSKQRPLPNIFNLYTIMTVLTQFAVHFLCLIYLVHEATSRSPGRDNKPKLDMDLADDEEREFAPDLLNSTVYIISMSLQISTFAINYRMHFINEAILLFSRENHLWKACRDNKPLLYSIMISGGAVLALAAGIFPDLSNMFEIVYFPPDYRIILVQVLIADMLFAYLVDRLCLILFGEGLRTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6R7</accession>
    <name>A0A835L6R7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Beta-glucuronidase</fullName>
            <ecNumber evidence="3 7">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002864</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:17633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:83411"/>
            <dbReference type="EC" id="3.2.1.31"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Inhibited by L-aspartic acid.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="3 7"/>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000027">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000628">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000080">
        <property type="entry name" value="Beta-glucuronidase UidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007538">
        <property type="entry name" value="PRK10150.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032581896" description="Beta-glucuronidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="12">
        <location>
            <begin position="55"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="10">
        <location>
            <begin position="236"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="11">
        <location>
            <begin position="343"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="689" mass="78652" checksum="6A57DB4010654CDB" modified="2021-09-29" version="1">MLRRKILLAFTTLTCVANAIVQNAATGNEIDSTPKKSQTSTGGPLYPQATETRDLRTLDGIWNFRKSPADPESGYRAGWFEQDLDKTGPVLQMPVPSSYNDVGEDVSLRDHVGVVWYDRRFFVPSWWGTAGQRVWLRFSSVHYATEVFINGKSVMYHEIGHLPFEAEITDFVSFNSSNLLTVVVDNTLLSDTVPQGVIKSVYVGPNKIRQEQQYTFDFYNYAGIHRTVFLYSTPQVYIDDVIVNTDIQGHTGFVVYNVTQKGATSDKVHCLIQLFDKNDTQVAAFNECAGLLEIGNANFWWPYLMHPNPGYLYTMKASLICSQGKILDTYSQKIGIRTITWSNTTIYLNEKPLYLKGFGMHEDSDLRGKGWDPVLWVKNFNLIKWLGANAFRTSHYPYAEEIYQLADEYGIMIIDECPSVDTDGFSDTLLAKHKQSLTELIRRDKNHPSVIMWSISNEPRSANKLADRYFGEVVRHVKSMDLSRPVTIAISAGASSDKSGRHLDIISFNRYNGWYANPGQTAQITNNVVEEATNWHRIHNKPVIMTEYGADTIAGLHLYPEYIWSEEYQCLLISEHFKAFDLLRKAGFFAGEFIWNFADFKTPQWRVGKGPQRRRDRLQPHVRHLKWLRSITRVGGNKKGIFTRSRQPKAAAHHLRSRYHALATSDYGVILPETTYYISDAQPAKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6V8</accession>
    <name>A0A835L6V8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6V8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="986" mass="113594" checksum="5D334853F24A7898" modified="2021-09-29" version="1">MDSTFVVTSLDSDRNPSRIANTDISFEKDWINKTVESEIWLGNKLREKKPVSKSKYYEQSVANIDFLGSFAKQCEETLRKNKYSKNKKNATSPNSKSPQRRRPKAAGTSYTAYSVAHKYCIPSSPRGRPKTSKYKNCPMRIAELAMPTKRQCIDTWRNKSDLLPGFMVERLKQHVLDQRPIVKIPEAIICFQRRNQSTSKTRCKSAEKKQGRYVNISKPCRHMDSRTLCIVFAHRISKRLSTQMNLTLNADLERLSKIIYGDIAKLLKFTFSKKTEYKAIHKDVSNKITIWITSILEDLSLKLLEEDLRDSKISLGDAHLSKQFVTPVETLLKEFKRKGAELNYSFKLEEEEGPALDFIDDLFDKVIGICEPQPVLAESASGESVSEKSRESGESQESNETEKSEESETAKLEELAGQSNQSLTPVDSNLRMEKLEETPNTVEADNLSDEQYFRKEIQNVMNSIQFDPEDYFKNEISNIIDNIDKESENYKSNGPEDIADKYIGVIATQLGIKNNINKADTITDSIINLKGTNKMAELPLKTEYVEKYKDEEETFDKLNIDENADEHIDGQNNDKRVAMYTGRNVDELIEAPNVDDENVDQHADHVDELGQNYSNVNERSEILLEESDDEMDSENVKLSHQDLGDADESWPDNLDAKLKVSDMYVHKLTTSLKDIMEMDESQKSPRKSVTPEKPEIPISKQEVEIFDYKFKDLANTEEYETDLQSFESAKENREITTVEPIQIYTKTLDRKSDKSVPVVEESDSKLTRDSENIRLDYTESEIISTESSFSGKGYKRVNRTSNRKPSYQKSSSLSDCGWRVKLSTAPSWVRSFGHGEPSDECLYKEIMPTRVTEADIRKWCNDLEKAYVNLEMWGQWIHCSCKETICLLKQKKTTCPGLVKRHTIHWLKLRRNIQKDCILWMKLYKRTKRNFNDLKSKYNNVEIVTAEYRAVCTCDRNSRMDIDLIKVIFPHHRISTASKYPLAIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L789</accession>
    <name>A0A835L789_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HF086_003981</name>
        <name evidence="15" type="ORF">HW555_004738</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L789"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="145"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9630690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="495" mass="55931" checksum="19F463A76BAC5920" modified="2021-09-29" version="1">MSGSNDKVSTTQRMIQSVAFPPSRKLTVSEVFDEKSGKPLPEVLKQHFILEGRIEENAALRIIQDGATLLRSEKTMIEIDSPVTVCGDVHGQFYDLMKLFEVGGSPSCTKYLFLGDYVDRGYFSIECVLYLWALKLCYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSEKVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINSLDDIRKLDRFKEPPAFGAMCDLLWSDPLEDFGNEKNAEHFSHNSVRGCSYFYSYAACCDFLQRNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMSEGDDALEEANLRKEVIRNKIRAIGKMAHVFSVLREESESVLQLKGLTPTGALPLGALSGGKTSLKNALQGFSPNHKITSFAEAKGLDAINERMPPRRDGQRTPDAQEKKAHVNSNAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z0</accession>
    <name>A0A835L7Z0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17339" checksum="89EB8C659FE31D4E" modified="2021-09-29" version="1" fragment="single">ENNSGVEEIIKYNNEHCHSPEPEYCILLFGTSENIRLLQLSPFWILDGTFRTCPTLFYQIYTVHGLIGVHDTMQKVVPLVFGLLSNKNERIYCLIFELLKSRASQFGVFPPNIWSVNSFIGTTVPITQNEVESWHHRWNTLLGRKKWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L833</accession>
    <name>A0A835L833_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L833"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21995">
        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000005">
        <property type="entry name" value="TOX high mobility group box family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051365">
        <property type="entry name" value="TOX_HMG-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781">
        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF1">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="577" mass="63394" checksum="8098A14056225D2A" modified="2021-09-29" version="1">MGPQPVCYGNRSERHETCGSRYYYNVDQSHFGTTIKTRPENLESPLSVPRDAKNSIYIMNDQTFHTPSFGDEEFDIPLIHGQHAANTGVQNSHIQYTQLHHSAPQVGMMNPAQDGLAPPGGAPSYQQPLYLQEPHTPVTSHRSAWKHTDNVMIKIGAGAPAGNYMIQQQPGGQQRLLMLQPTQVMNGPPTPSTPTQPSAPVYGSPQRASPPGTTSDDSDDSVPSHHSQMSVGNMAVKRSSPEPMDNGINRGQMQKKPKVQKKKKKRDPNEPQKPVSAYALFFRDTQAAIKGQNPNASFGEVSKIVASMWDGLDSEHKSVYKQKTEVAKKEYLKALAAYRASLVSKGGEQESQPMYNHTNSANPTYGNYYQGQTYGNGHSPQGYAPNPASQGYSPQNYSGNQNQASYPPQTPQGYPPNPQQSPQNYQGNMSLTPQTYQQGVPNQSPQGYQVNPSTSPQGCQPNLAQSPRNYQPAQSPTNYPNNSALSPPGYRQVQSQSPPMGSVHAAMQYHHSQQQQNENRSTPSCIRQGCTNPAIANSEWEDEYCSNECVVSHCRDVFSSWVASNNSNQIQNFSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9E7</accession>
    <name>A0A835L9E7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_014053</name>
        <name evidence="3" type="ORF">HW555_003369</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9E7"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF58">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="158"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9639189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="413" mass="44309" checksum="CA95D2F8F60BE5F3" modified="2021-09-29" version="1">MQAGGPDSTAVSEAPSSGSEDSDCEPGPETDADAALTEEWARELLAGAGVVDPHEVHVESRAGVAGALSRVLAVTVCYESNGERRALPLVVKLPPRDPFGRLFVAEAQFDTREILFYTELAPALNKLAEEALGPGSGLPVPRCVKARLPDEIGGDSELVLEDVTSVGYEAADFAEGLTEERARSALFAAARLHALSLALRDREGPLDQRFDFLFPCERAAAGYLRLVRRGLPQLEAFLRGRPDCVEEAAAVSALSARAPSLLGTLLRPAEPAPLAHADFWSGNLLFREREGVSECIALDWQMVSLGRPMDDVALLLLSSLTPELRRSVGDTLIEEYGDRLEAECARLGAASAGVTVRRGLRPDWPRAALRALLLCAGSVDVALGEPRAERRLLEAVRDLHSQGVLALRPDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA46</accession>
    <name>A0A835LA46_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA46"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1440:FF:000001">
        <property type="entry name" value="phosphorylated adapter RNA export protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="208"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9424960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="375" mass="42795" checksum="D3D628281140C693" modified="2021-09-29" version="1">MMSTTEGELDVEVPLEREEGELEDSDVEEGTYKPLARPEAFNPPSLVHMQIQDEQSDEGSPRESSGSESDDEPRRRAKRTKLRPRRPAPQPDRKDKYNIWCKALQEDLLTEDMVTCDVSKKSRYGVESYDYTIKYRLDDNFINKKKIFSNNDDYDDSERVSNKRRREDRSNVKLRLGKRDSSHNRNDKLKPRILCDLVVSAEDTAENIADEIADNLSEDKKDLVGRIVQVVGANKAIEIYKETQKLEADGGMLVMNGTRRRTPGGVYFFLLKRDGDVSQEMVNQIFTEDRKETQRKIKRARAKSHSELPSLLSRGEATVQSEHGSNPPPSPATDARDCSSDTDAPCDASAPPRSPREYDDDDFLEVMCNDDMDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBA8</accession>
    <name>A0A835LBA8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_005349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBA8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="169"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9417642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="366" mass="42939" checksum="741159011F43BEE4" modified="2021-09-29" version="1">MRPFLETTEYFKASEPRTTTKYILLWTDPNLHPFVYFGEGNSVFAKAKCEYTNCYVTSNRELLRNSAEYDIIAFNGPQLDVADLPRLRSFRQKYVYANIEAAANYPICTDDWNNFFNWTWTYKLNSDAIWGYIVVMNSSNHIIGPSLEVDWMSVDDMAPIDDALKQKLETKNKAAAWFVSNCETASKREEFVNELQIFLGDFNLKVDMYGACGTFQCPKEIMSKCLEEIEKNYYFFLAFENAVSEDYVTEKVLLALNHYTVPIVYGGADYSRFLPPGSYLNAKKLGAKNLAKEMYDIIENREIYYRYFRWRQYYSFGRRFENPDSNEYCRFCAMANDENLMKETKTYHNFSSWWSPEICNFTATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCF3</accession>
    <name>A0A835LCF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000170</name>
        <name evidence="2" type="ORF">HW555_013576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000671">
        <property type="protein sequence ID" value="KAF9405846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18451" checksum="DA88C3881F2F8161" modified="2021-09-29" version="1">MDKNMELLLRKLDEKLEKQANLITQSVTKNVTEAIDEKMNAIMEENKLLKNKVLELELKIKSLEREKRKNNLVFFGVEEIGKTERELVDYIKDTIEESGVQMNSQEISNIYRIGKQAENKNRPVVVSSQPNGRNTLYSRISRGSHQKYMLKKITLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LF42</accession>
    <name>A0A835LF42_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LF42"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000179">
        <property type="entry name" value="SCY1 like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000189">
        <property type="entry name" value="SCY1-like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="846" mass="95028" checksum="F1FA94E19EB6B521" modified="2021-09-29" version="1">MEVFNKFYSSVSNTVSQLSGVLPGNPVTREFEATQFIASAGPGLLWKIYKGYKKSTKQEASIFLFEKKHLERWSKQDRDIMLETLKRGIIQLTKLRHPQILTVQHGLEESRESLAFATEPVFASLANVLGNTENMPQPTPSHLVNYKLYELEIKYGLMQIVEGLSFLHNDVKLLHHNICPESIIVNQQGAWKIFGFDFCIANQSPPGSAPFWPFNEYCPAMPALTQPVLDYLAPEYVLSATHSPASDLYSLGMVIYALHSTGHQTLGNVGNDYGKFKRFVNEIRNLSPSRLSCVTDGLREYVKLLLNVTPELRPDPHQFLKIQYFEDVGVKTLNYLDSLFQWDNLQKSQFYKGLPQIIQKMPHRICIYRILPCLTKEFVNPPMVPFVLPNVLLIAENSTKEEYIKYILPVLKPVMMIQDPIQILLIFMQKMELLLKLTPGEEVKSDILPMLYRALESDAQQIQELCLSVLPTFASLIDYPAMKNALLPRIKKLCMNTNYISVRVNCLLCLGKLLEHLDKWLVLDEIIPFLPQIPSREPAVLMGILGIYKLALSHSKLGITKEVMATKVLPFLIPLCVENGLTLNQFNALITLVKQMISKVETEHRAKLEQLNSINNESKIMEQTMSPSSDTLVSAPAPPSDLDKMFSGLGIDPFSFNQAKEKEPPATPVVTNNGRLTIEDKQRIAQQQENVRKFSNQQQPKAIPAPRSTASAHKPVDLAATLLQSNLNQLSKPLPSSVPHPVTPSQSMAPLSNTHFTNTGMAANSNFGFPNQFTGLDTQPALPSNWNAPSSGNFNNKWANNQTQSQAKKQDWSAFESLLPTPNNNTTTSNSNVKPLSDNEMMDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFG2</accession>
    <name>A0A835LFG2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_001279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFG2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02983">
        <property type="entry name" value="P5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032920722" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="279"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9423210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="572" mass="63478" checksum="1885C334A66645E3" modified="2021-09-29" version="1">MLHTYFLGILLCVGSGLALYDSSSDVVDLTPDNFNDLVTNGYETWLVEFYAPWCGHCKNMVPEYKKAARALKGVVKVGAMDADKYRSFAKDFGVSGFPTIKIFTGRQHVAYKGGRTADAFVDAALKAVKTKAYERLGKKPEDSSEKPSEPEIYGHNIPWKQAQKAFKTTKMSLSKNITQEPTKDQATCMPDRTEFNDSQSHGDKKSILRMKRPIKKLNIKKTAQKITTTDSTTTTVITTETPEDTTSRLTILEKFKLLQSQLFRGDVSVEEKPKIIKALLRLKYVLQGKGLSSSGSDVITLTDDNFKKLVLDSDDIWLVEFFAPWCGHCKNLEPHWAKAATELKGKVKVGALDATVHQEMASRFQVQGYPTIKYFPSGKKTYDSAEDYNGGRTSSDIVSFALEKLAENVPAPEIIQVVNEASMQACSEKPLCVVSVLPHILDCNAACRNDYLAILARLGDKYKNKMWGWVWAEAGAQTALEESLELGGFGYPAMAVVNAKKLKFSTLRGSFSETGINEFLRDLSFGRGQTAPVRGAEMPKIVSTDAWDGKDGELPQEEEIDLSDVDLEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGG6</accession>
    <name>A0A835LGG6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="349" mass="38247" checksum="1635A0F00F3CCDC2" modified="2021-09-29" version="1">MNGGHVLAAGRELADLEPDEQVVLGVQVRAAAGRGHGGGAPLGAAHRRRYRDRRRQHAPRGRAAPHHARPAVLLRVLVTLSIILYMVGRHGYWQKEYIGVVCGHTVSLQHGDSECELLAQREVLGQVLLLQLGGQGTVSTTTKIVPSILILESGTSLMRSSRLIALFLSTADSLVRRAGATSSSNEIFADCFTPAANSALSTKSINHLLKNSDVFLSLTAEGYVKDQIENTIVQDSDVKNLIVTLVLTLFSVDNSLHGYSKVALDVSFLIHNGHFMNERNRIQQTEPRESVVERVTASNGLNIMVRRSRRQLGFIVVHLTHQLQTLPDTAIRSRHGHYEIPSSYISTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGM5</accession>
    <name>A0A835LGM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetratricopeptide repeat protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_008966</name>
        <name evidence="7" type="ORF">HW555_000142</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000188">
        <property type="protein sequence ID" value="KAH9642556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9642556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31099" checksum="2D03D1553AFEBCE6" modified="2021-09-29" version="1">MSAEDELVHTIKHCILFIQRNEFEKAEQLLHVALRQAQQIRHELGITYVYDVMANLALQREQLDKAKQLFIAVTQRIMADGAQEDDPRVIHLSVKLARVSHLKKDYSTAQLGYDWCLEKLHRLVETDPSDATQKLLAIAEDWYGRLFVDLNRCEEGLKLMKNSLDRMKLVSDTDKEELVFQLNDIGTVCDRLGLADDSIKYFKEAIELAKTSKIEDVGTMYVNLGRAYIKTQLLDAARKSCGYAWKLGVMSKNQDVKQEAELCIKQINNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-01-23" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A1DYI5</accession>
    <name>A1DYI5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cathepsin B-like cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CB</name>
        <name evidence="12" type="ORF">HF086_004044</name>
        <name evidence="11" type="ORF">HW555_000814</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2006-10" db="EMBL/GenBank/DDBJ databases">
            <title>Functional Analysis of Cathepsin B-like and L-like Proteinase in Beet Armyworm, Spodoptera exigua.</title>
            <authorList>
                <person name="Liu Y."/>
                <person name="Liu J."/>
                <person name="Xu W.H."/>
                <person name="Zhang W.Q."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EF068255">
        <property type="protein sequence ID" value="ABK90823.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A1DYI5"/>
    <dbReference type="MEROPS" id="C01.060"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036278694" evidence="8">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABK90823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9633330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="341" mass="37681" checksum="5E301C83AA9BC127" modified="2007-01-23" version="1">MVASRATFVALVCTLALASASVEDLLNPLTDEFINLINTKQNSWKAGRNFPVNTPLTHIKKLTGVLVDTHLSKLPKVEHDADLIADLPENFDPRDKWPNCPTLNEVRDQGSCGSCWAFGAVEAMTDRYCTYSNGTKHFHFSAEDLLSCCPVCGLGCNGGMPTLAWEYWKHFGLVSGGSYNSSQGCRPYEIPPCEHHVPGNRMPCNGDSKTPKCHKTCESSYNVDYHKDKRYGKHVYSVSSKEDHIKAELYKNGPVEGAFTVYSDLLNYKNGVYKHTVGNALGGHAIKILGWGVENGNKYWLIANSWNSDWGDNGFFKILRGEDHCGIESSIVAGEPLLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0Q5</accession>
    <name>A0A835G0Q5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_013858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000750">
        <property type="protein sequence ID" value="KAF9405383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0Q5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="47"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9405383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="243" mass="28205" checksum="E9F71E3767A44BBB" modified="2021-09-29" version="1">MNRRNNDTEGTDLSKINFRTFTNIRPVHHVVFAYEKDMTIIVQPGKIDCFFHKVVADEIIDIEYQVIDSTHGDLDISFQMADPTGRMIVADFKKPENSHRHTATIEGDYRFCFDNSFSTFSKKTVFFDMLIEGEEPEDRDYDDDKEMELGNAAETYMMRVRDISESVTRVKDKVSTARRLQELHSAHEARDRNLAEDMCTRVLKWSIGHVVLMLLVGITQVIFVKSLFEDTRNYRKLVPGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2E1</accession>
    <name>A0A835G2E1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_013055</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000567">
        <property type="protein sequence ID" value="KAF9406648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2E1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000015">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF462">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="486"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="849"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9406648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123083" checksum="786BC80146054F77" modified="2021-09-29" version="1">MKCSRSDTCGPQWKVSMTKQALAALSEGGSVAGSGCLGAQVCGALGAAARALQRPVGAGCAGAEARGAAVARLAARLGWRLALVPPAAPASDCEAALVEVARALAVAGVAVRRVNLLQDELERQPNVVILCTGRGAGILAASAATLGAEGAGPPALLVHVEECDSTPLTVSETSRAPLSDVNNATRLSNITLVLSEYLKTRSKRQSQFEKLMKNDLRTNISSNRLEKIPTETRFLNQQTDAKHTSHRKIKTDSVQLKAKHNEEKTLTEQQALKHAVSEIELERWRRESTGEPEPERTGRPDFTSNPVQFYLPQIEILFFRRLWLLTDEQFMNHSYLNETIIYDEILQTVQVESKARHAKKENIHINFHLYEKQNRTSPYWSRAAVLATTMSRSLELSYEQAISVKLLNVSVALDSWSSAGAEGTAGTAGSGRESTGAAALSAVAACGALALAATIALLLRWQLHEFGGPELERPDLLKQPPCVPPRAPSAPSSTCSVNRVAVDRRIRYKGDVVHVKYLPATAGLELKRKATDVLLVMQNLRHENLNPFIGKLFNTKHFFRYYYLLNEVITTHAFAGCLCELRPALVFDQCGRGSLEDVLVADDIKLDWTFRLSLLTDLVKGMRYLHASPLRLHGRLTSRNCVVDSRWVLRVTDYGLPAFFHAQGLPQPHRSARDLLWTAPELLRENNGAGRGSQPGDVFAFAIIMQEVIVRGEPYCMLALTPEEIVEKVSRPPPLIRPSVSMGAAPPDAVSVMRQCWSEAPDLRPDFHRLHDIFRHLHRGRKINIVDSMFEMLEKYSNNLEELIKERTEQLDMEKKKTEQLLNRMLPRSVAERLLLGSRVEPEEFSEVSIYFSDIVGFTALAARSTPVQVVDLLNDLYTTFDAAIEQYRVYKVETIGDAYMVVGGLPVRTRDHAEAVATMALHLLHLAGRFRLRHLPDTPLHLRIGLHTGPCCAAVVGLTMPRYCLFGDTVNTASRMESTGQTLLRGRGAGDRAGTDRAAWRIQVSATTAERLTAAGGYRLRSRGLTMIKGKGAMHTYWLLGKDGFDKPLPTPPPLQSEEVLFEVDGENECESPGPDQSPPAAARAGVERQRSDPTGTPDRQGASRARCRTAAIVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2Z8</accession>
    <name>A0A835G2Z8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribose-5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000952">
        <property type="protein sequence ID" value="KAF9404533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2Z8"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="179"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35368" checksum="F71DC23CF1EB4A19" modified="2021-09-29" version="1">MNLKQQAGIEAASYVKDGMIVGLGTGSTAKYMVDEIGRRVKDEGLSIIGVTTSNATEKQAIELGIPLKGIDEVPYVDLTIDGADEISADFQGIKGGVFSRHGLSEWNALNQFTGWVDVDLAPEGIEEAKEGGRKIKEAGIEFDIAFTSVLTRAIKTCNILLENSDQLWVPQVKSWRLNERHYGQLQGLNKKETAEKYGDDQVHIWRRSYDTLPPLLEVTDPGSAANDRRYAMLDKRDVPGGENLKVTLERALPFWQDEIAPALLDNKTVLVAAHGNSLRALAKHIEGISDEDIMDLEIPTGQPLVYELNDDLTVAKKYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3C2</accession>
    <name>A0A835G3C2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger DNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000751">
        <property type="protein sequence ID" value="KAF9405376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3C2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32463" checksum="BC4858326087206C" modified="2021-09-29" version="1">MTKEYYSKNLSELKRAWACPSCTNIARRKNENTPVRNQFEILSEEADMSCDDLLPNTSGTDSDSRMFQQASIRTSANKQLSLVPETPCSISYERFGELLDFKLESIRVALAADIKKEITAAIENLKDEFTRTTDFLASEQRDIQDKLASVDSTITSLESENIKLRTEMNELKRRLQTLEKSSRCRNMEIHSVPERKTENLFAIFEKLCKEIKVSTPNTDILSIRRVAKINSESDRPRNILVTLQSERQRDVLISALRQYNKENKDNQLNSSHLGISGENVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G450</accession>
    <name>A0A835G450_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000714">
        <property type="protein sequence ID" value="KAF9405598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G450"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="8"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="532" mass="58992" checksum="3054610FCC50AF46" modified="2021-09-29" version="1">MRFGIYNISHMLMSGVILLGMIMQSLALGYILPAAQCDLDLTLQQRGWLSAIPFLAIILTSYLWGWLADTQGRRPVMLFSMMISAVFSAFASFAPDVISFGILVFLSAIFMSGSSAVVYTYLGEFNNLRHRDKMVAFGSSFVGIGTVILPSVIIRVSWLILPLEFAYPISILGIEYRPWRLLVVACALPFALGSVLLAFAPESPKFLFATGNYDAALDVVKRIYHRNTKKDVDSFPIKSLIVEHQMAKTSNVQGLAAIWTSMKEQTVPLFQRPLLAWTALTCFVQFGIFATTNGFYVWFPSILNSLAHHEGGETRICDVLDAGRDAVSNGTMICDDTIHTSTFERSIYIGLVFSSMYIIVGFLVDYVGKKPILVVILGITGICGICAHLAYNQQLAVVLFAVFQMSGACIGLMNAVAVELFPTKFRAMAICLSMMMGRVGSMVGSNLIGLFLEVNCGAGFYLFGSIIIESRRRCSKFPLLSYATKQEENTTQEDCSRVHTERDPRTGMNRLQPDLYWTELVNSVYEESLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G466</accession>
    <name>A0A835G466_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000902">
        <property type="protein sequence ID" value="KAF9404707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G466"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="650" mass="74733" checksum="66203314ABB54D21" modified="2021-09-29" version="1">MNTVKEREERLLAMKNYTNLRLRQETLEQREFRNAKIKKRLANETSEQRAHRLDNESPEQRAHRLGIIHNRLANESAQEREKRLTTMRQSSQRQRSMIERNFINTINQYTEEPCTVCKKILYPKQKMVLVPTRFEFLPQEVAVLEKNIVCSRCSTTIKKRKVPSQAYWNNMEVISLPPELADLTDVEQRLLSRVVPFMKIIKLQNRFSQSWCRGQVILFAQDVVEAAEQLPLPLAQAGIVVLFETRDNLPNHKQFQVDIRKIKITFQGSCVNLNIAHDLSINGHFSRDQEGYPNLENGIASFFDNNYTCGILTANFISILMPEGPKGHKGRTGGVSCCLRFENSRQIAALLRCNLKATGLPEYILNIYSITPVFVVESGGYTRIESQHSERNLNRDRRLILSTSMLYDIDENIPNLDRVIESDNRNLNENRVTDIHRKTAPPVNIERERRMEELYWYTMYPDGKNGFETNSSLLQTEMSKEADQPTGYQCKKDIEMSLDEFNSPSGPVQDGLLNDEVHQKKMLPCEALAVPSTSYNTSYCSTPTESRTLAEIISSVKLDHRYVNTPQSSKNKLERVKRALKMSQARIKVLSQNMKPGEKRFIDPIVKFYPIKKNNEVKERVNRTHKFVGLVVGGSVCYAAGHGFDSHSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G470</accession>
    <name>A0A835G470_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000573">
        <property type="protein sequence ID" value="KAF9406586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G470"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032402285" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="67"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="356"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="651" mass="71163" checksum="E64A3334BBCD2DE0" modified="2021-09-29" version="1">MKSLVILFCAFAFGAALPYDPVLRKIDDGPRYQHIEGPDGTLHLEDLWVKASDLAEAARYNPDRQNVYHLYTRLNPTVSQPMLIGNEGLLGLNNYNPARRTIILLHGWRADATSDFNRVLVPAFLSAEDVNVIVVDWSAGAGSINYATAVTNTVPSGESVARFIDWLNTVTGAVPSMYHIVGHSIGAHKAGIIGRNLGGRIGYITALEAAFPGWITHSEKFRSTDGAYTEVIHTNAGVLGYITPLGHVDFYPNGGVGMPGCDSQECDHARSYFYLAESLTSGGFTGRRCASYLTAMTGNCVLLGRLRMGGLVPKTGQSGIFYLETNPAPPFSPISFRYKRSETKQSNRLRIHHRKSSDNVLMDLWTRASDLDEASTYNPEEMNTYHLFTRENPTLSQPLLPNNEIWLETTNYNASKRTIVLIHGWLDSVNSDFVTVLVQAILQAQDANVIAVDWSPGSGTINYPVAVLNTPISAHAVAKFLAWLNNVSGSRLEDYHIIGHGLGAHQAGIVGRLLGGWVGYITALDPAFPGWVTNEDRFKPTDGMYTEAIHTNAGLLGYLSPVADVDFYPNGGIDMPGCYSQECDHNRSYHYFAESIKNGGFVGNRCYTYGSAMSGHCYLGGKLKMGGINSKPGQTGVFFLRTNAGPPFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4A5</accession>
    <name>A0A835G4A5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a non-catalytic accessory component of a dynein complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000622">
        <property type="protein sequence ID" value="KAF9406235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4A5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9406235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="94" mass="10923" checksum="A324D7B68622E0A0" modified="2021-09-29" version="1" fragment="single">HIADKMCDRKAVIKNADMSEEMQQDAVDCATQALEKFNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Q8</accession>
    <name>A0A835G4Q8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000767">
        <property type="protein sequence ID" value="KAF9405281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Q8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="90211" checksum="8469D322EB55A930" modified="2021-09-29" version="1" fragment="single">RKQIYHTTTIMSATMENILANQDQIIQAMEQQLRNFKKDSADRKTPANIKKRLQILDSYWREFQENHAKLGEFEDRGYAYFSENMYDKARIFYNEAQNIIQNYKPPTSLEKGGTSSIHTSDTRNQEAADERQQTSILSVDPDKSNIKPIGTPSTSLFKKIVSRGNASKLEEMLRKQKSNFKALSRAIRNVDIESLSEKWEFEDVLKTIQGKWSTIDSLHWEIDSEMYSEDEEYELEYSNHEQQYVDIKKLVNSKMYSVSYRESFTPKIDIPTFFGNYHKWISFKDLFQEAVHNNKSIPNAQKMQLLKTKLKGEAERIIQHLNISSENYQVCWDILNHRYNNDRLIFTSHMNILLSIPTMQNQVDTQIKNMFDTINECMNSLKNLGVDVTAMGPMVVHLLTLKLDTQTLSEYTQSLDNPRALPVLADFLNFLENKYTALESTRRKHYSSKSSSSSSPSRNKDSEHQVSKKNQSKSNNFNNKIDSNKPFLRSSAIKSCATRTQYCPLCKDNSHGLFYCKPFLESGSAEKRNTVQRFNLCENCLVDHKNKSCRSESRCRVCQGTHNTVLHDALQVNAVSSNMDKSPSMSCEDKTQSNVTHACKESVVEILLATALVRIQGINGEYHTMRALIDQGSQASLITENAAQILKLPRRACKGVIVGVSANQTNCKGVLSLVASSLYSNYTFQTEVTQLGWILSGNVKSYQCNVIMNNIEDIQRFWSIEDVTDPNTDIGGSRLGRVAGVQEALSCWCIAAIGTGCGRSKSDCKLVLPFPRRQYHRNVKASAEITAPNNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5G1</accession>
    <name>A0A835G5G1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000608">
        <property type="protein sequence ID" value="KAF9406325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5G1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="206" mass="23021" checksum="7EB495A78E37DA2A" modified="2021-09-29" version="1">MKQLPCFSRAPVSTIPSKTERTKDSSTDIELSLHAPAPAQTQIISKGRRKPCSCLMGNANSKWPIECCRNGKLRKMVDLDEGFGSSSVQLNEEIKQFLEERAEDQAQFHAITEPKPNSKRTIYVGGLAEEVDEKVLNAAFVPFGDLVDVQIPLDYETEKHRGFAFIEFENAEDAAAAIDNMEFRNAGQILFSLWETFSATDFDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G605</accession>
    <name>A0A835G605_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HF086_000782</name>
        <name evidence="15" type="ORF">HW555_011941</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000390">
        <property type="protein sequence ID" value="KAF9408331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000256">
        <property type="protein sequence ID" value="KAH9641134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G605"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9408331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9641134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="313" mass="34616" checksum="ACB1C6B3E54C9547" modified="2021-09-29" version="1">MITVLNTIDTGHEDMIHDAELDYYGLRLATCSSDNSVKIYDIKSGTQTLAADLKGHFGPVWQIAWAHPKYGNLLASCSYDRKVIIWKESGEWTKLYEYTGHESSVNSIAWAPAEYGLILACCSSDGSVSILTYSQEGGNWDVKKIPGAHAIGVNSISWCPAISADLNLDPLSNKDAPKRIVTGGCDNLIKIWREQGDQWVEENRLEMHMDWVRDVAWAPSLGLNRSTIASCSQDKRVVIWTSDDNVSWTPTILNTFDDVVWSVSWSLTGNILAVSGGDNKVSLWREGSDGQWLCISEVAKGLGQTPNDERSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6L8</accession>
    <name>A0A835G6L8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear envelope integral membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000533">
        <property type="protein sequence ID" value="KAF9406888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6L8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43590" checksum="ED978E4264E4A31E" modified="2021-09-29" version="1">MVIHWLGGPTTIERDVPTPNKQTIDIYCYRGTSKNLFAIWQTVKFNIKIKNNEFSQYIGESPADVYKEFSEDSYGWSSVVNPFQKKPQKSVSINLFTPTCMAINTRERHTIELQVLRVDLWRIMLMAAGLVLIFSSRALCGNPVFFYLCGIFVGVFASFMVLVYYISKLLPRKTLTYGILIGGWTVGVYLFQQIWENIRTLVLTYQTYMFWYTMIISFVSFLVCYRIGPPKNERSKNLVMWTLQCVGVLMIFFSSDYQEASAAVIIASLVAKYFPQSLTNRICGYWRRKFPPKQKLLTSEEYYEQGARETKMALENLRKYCSSPDCAQWKIMLKLNDSKRFASFVEGNSHLSDDEVLDYEAYAFSLERYGASAGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7Z6</accession>
    <name>A0A835G7Z6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7Z6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="1">
        <location>
            <begin position="124"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="2">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="62402" checksum="A6A1C723EF55CBD4" modified="2021-09-29" version="1">MSKTKLFKKIVKSLSVPTQTFVNMQLTQYKKKNRGRRFSIKEKLLALAIYIKSPKWYNFLRKIFAIPSKRTLKINDQSTINSKVVHELLSETRGEYLKKNTEFKYNAFEINNQKIFPLFDAPRLLKCIRNNLLKKDLRFTQDDKQKTAKWEHLKLLLDLDDGEDELRMCNKLTEAHVLPEKIPKMKVKHAAQVFSQRVSQVLLDFVLDIDNYHIENRKHLLPQECTDTADLLLLFDQLFDSFNGRSYKITHKIYKTCVKNNSEHFTLWNKILPVLCSMAFKTEAKKGWYYDMKDFWQYLTFKSNQIPVENFFSSVRSHGVRNINPTFLQFENIYKTLLVNDLCSNHSLGANCEEDTNKMLHNLDVLLMNNPPEPPRNNDDDKIEEICSNDILAGGSDNELVSETKKYEAGYVIKKTKKMICKSCNTCNLDLYDTTPPEVDNYIFSIDITRKSLQYPLQNFTICVNNIIKIIKHFFKNCPHKSGIIRKIKILVRNIVQFDFLSCDIHKEKIEIYVTKFLIKCIIYSWCNNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G831</accession>
    <name>A0A835G831_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000387">
        <property type="protein sequence ID" value="KAF9408372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G831"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="18277" checksum="D7B24D185B1C3DF7" modified="2021-09-29" version="1">MVQGTALKLEGFKMDTAVVEQLLNFFQDYIGLCQCENWPDNDTTEAEIKNAFVIAQHIEKSLDRLQKKQVINEFLCVLNSNNESSSNLIKNCLSDPPKLSVPEATPFTAVLKFAAEEFRVEPATSAIITDDGIGINPQQTAGNVFLKHGSELRLIPRDRVGHTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA76</accession>
    <name>A0A835GA76_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032845585" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="141" mass="15923" checksum="A07724F042395110" modified="2021-09-29" version="1">MKILAVVLLVAIAAGVYSNEEQGANMLNYDEQSMEKSDQLASRSSFGWGVVGIDDRLISSTYHEAYGYQYLINEQEVTYRGNQYTNISSIRVYSNYRNTTEIVLLDGGLNENYVTFGFRSPRSEGFGCRIDIYATINCHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBM7</accession>
    <name>A0A835GBM7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Suppressor APC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000231">
        <property type="protein sequence ID" value="KAF9411257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBM7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="3">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="419" mass="47976" checksum="CD6DF6DCD9955A6F" modified="2021-09-29" version="1" fragment="single">MLDFKIMNRDSSRNMESLPKQFVSAMRTLFDIMDDKHTGYVKLTDIENRWRDDRTRGLPRGVIESLQKVASPEGLLTFERFCTGLKICLLRNQVDNNSGKDDRFSDVIENTGLHSQMVPQTHRPPSAPLLDVNDSQNIDRNWMVLKSSESSSQHRTISMPQLIGRKEVLLQEPRHLGPGSISKHDGSRRVYGPPKPPRLEKPTTERNETSKSSYKSEEEIVFEGEELSVDKIDFEEMSRAVEEQSRGLGDGRSANETQSQMRRVSRRREPRRHTLHNGVDYNLLKRMKQIEQEKDVLLQGLSAVEEAREWYLKQLAEVQEKMRYAGRMGAYVEPWSEAHQERLELLKARILELNRQLGALAAGWRHGQLSLHMNLALPAASLSTTGSSATPNNAAVLRSQNRMLAEEVNRKNERITVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBT0</accession>
    <name>A0A835GBT0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBT0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="30592" checksum="D2B14E43AD75AF81" modified="2021-09-29" version="1">MPNSHRRRGRSVSRESRHHRRDVRSRSRESRSRGRISRSRGRESHNSRLDLQGNRIPDIASNSLLTQQMQQILDRLTSLEEDRRVSRAASLRQPSNQQQQLVEETATTARDGAGFRDSAAPSSPGRSVSAAADRDATVTDRLIDAIRSINTTAQSTGKLDSGMRGPYRVVKALPHGRYELQLLAGSYGKSTQAAAQFMKPWRGEWTPETCAAYFDGADSNDDNAESTPEQAANVDTQPTIDTSPEPMPSTSRAAEALQPQPQENGDVLQSGEAVLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCG2</accession>
    <name>A0A835GCG2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCG2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="197" mass="22939" checksum="7F6414B713060E08" modified="2021-09-29" version="1">MCVTGNVKAMSSKCDMCPGVHRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPMHLFGIRKQWDSKAINDLTDSYGQEWTYRDRKALEFTCHTAFFVSIVVVQWADLIICKTRRNSIIHQGMRNWALNFGLIFETALAAFLSYTPGMDKGLRMYPLKFVWWLPAIPFMLSIFIYDEIRRFYLRRNPGGWLEQETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE60</accession>
    <name>A0A835GE60_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE60"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="106" mass="11327" checksum="E290F124EE04DD4F" modified="2021-09-29" version="1" fragment="single">TTGFPLGGFSATDTISEGKTPVQTAYSDPTHCRRVSTAPLGKGIGRAKGHSDKDMRSYMQKRTSSREVHSEGETGGAGMSAGAEALAAQVARFKRLSLRKLRAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEI9</accession>
    <name>A0A835GEI9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_005270</name>
        <name evidence="12" type="ORF">HW555_006680</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000019">
        <property type="protein sequence ID" value="KAH9645621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEI9"/>
    <dbReference type="SMR" id="A0A835GEI9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9415779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9645621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41777" checksum="B5D215C675D7A119" modified="2021-09-29" version="1">MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEZ8</accession>
    <name>A0A835GEZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000149">
        <property type="protein sequence ID" value="KAF9413849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="167" mass="19566" checksum="B831494735207AF5" modified="2021-09-29" version="1">MNMTTITFDEFLASAKEFEQKSKELGDGWTLKEDKVDNLKTYLRKNTFVQYEDGNINHLLKVEYVIFYNLSYGVPSFSFNAWNSSGILLTFDEIRKMSFIQINEKDFYSVITQQEHPIFQRPYFIMHPCHTETLLAAFKNNTKNIIVTFLGLITPLIRLNLPLEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFT5</accession>
    <name>A0A835GFT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="12902" checksum="253403C5663E779D" modified="2021-09-29" version="1">MSDYNESLSRKTRSRNLEPVAKIGYMDGASDGQTAEFQNSFNIGYEQGFTFGLQLGSNEAILSFKPEKKPQDLVDQRRINCQICTNIASAQDNVVNLFNIQQEKNTEYLLQISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFV9</accession>
    <name>A0A835GFV9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000079">
        <property type="protein sequence ID" value="KAF9417043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFV9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039210">
        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="105"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="36270" checksum="53525E4A3A0FD695" modified="2021-09-29" version="1">MQDVRKRAKSNDKNVSERNIPKNNESNVNNNKIPTTQRNISLRIISRVVVIFSLLIVVYFSSKNDKVKTFAKQSELLPGKGLVVDCSLSYKEEVEKYEGCVPKECKRFITDKVISVREAEELLAIAKKGLQLGGSSGGASILDLHSGALSMGQHFVNIYKREDAKHIFSETDFNIYRVVKEKIKYAVAHHFGVKPNKIYLTHPTFFSEITSKKAVTMHDEYWHPHVDKETYKSFHYTTLLYLGDYNIDFKGGRFVFVDEKFNRTVEPRKARLSMFTSGRENLHYVEKVTSGNRYAMTISFTCDQQYAIQDPSINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGI3</accession>
    <name>A0A835GGI3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000118">
        <property type="protein sequence ID" value="KAF9415078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7875" checksum="B2AA6EC117CFECC2" modified="2021-09-29" version="1">MKIDTNLFEFEDDRCQPVLPKWLVFLLGGSGNQGRKAGGAKAAATRAADDGGDHRKGTSHERRRSKHRKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH12</accession>
    <name>A0A835GH12_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_004955</name>
        <name evidence="6" type="ORF">HW555_007462</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000894">
        <property type="protein sequence ID" value="KAH9628795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH12"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9628795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="14492" checksum="65C7953725540409" modified="2021-09-29" version="1">MGKVKCSELRTKDKKELFKQLEELKTELTNLRVAKVTGGVASKLSKIRVVRKAIARVYIVYHQKMKVNLRNHYKNKKYKPLDLRTKKTRAMRKALTKHEAKIKTRKEIRKKSLFPPRVYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHC1</accession>
    <name>A0A835GHC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9415486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="373" mass="41267" checksum="12455FD109AA14E8" modified="2021-09-29" version="1">MGQNQSGGGSGGDKKDDKDKKKKYEPPIPTRVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVSVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMTLADDVNLSELIMSKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKESVLYRKKEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHM4</accession>
    <name>A0A835GHM4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHM4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="290" mass="33964" checksum="1BA1BC11D78416F2" modified="2021-09-29" version="1" fragment="single">FHRQITQVTSSDIEKRIAGLKEQLRQEIREAQNTPESTEPAAKTTSFKLPEYDDFAVTESDKILIKPIMEYHHKTKTHYYNTVKGNLTTKAIDLKKITPKKLKRFPLNKNNNMNRVTPANVSLHNRRFHLDEDERNKPQMWTHCLDLITPRLKGYKDDWSPKEVLAHLLSLNTSEYTKEEIISTLYQISNLKLRIFQWDYTALTTIFNIIITEPMHNFRSLKNGLKRLFKSWHLDTSMITTFLKQTRIFRPPCIEVSHYGGSTKTTGGVRVSKPTRNQNKKKNDDDDCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHU7</accession>
    <name>A0A835GHU7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHU7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000502">
        <property type="entry name" value="Actin-Related Proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0558">Oxidation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="333" mass="38112" checksum="71CE54D47F8C9B59" modified="2021-09-29" version="1">MEGLRLFTLPIAGGTFRIWCFLSFVEEVVQSCSNSNANGCYSDAKTTTWAAIFLPIFLTIGRPKHVRVMAGALEGELFVGPRAEEHRGLLSIKYPMEHGIVTDWNDMERVWNYIYSKEHPVLLTEAPLNPRRNREKAAEVFFETFNIRDRSYDGRGLGFRLLLRKEGVNLRTSAELEIVKSIKERACYLSPNPLKEETLETERAQYTLPDGTGLEIGPARFRAPEVLFRPDLIGEESEGMLKSDMDLRKVLYQNIVLSGGSTLFRGFGDRLLAEIRRLAPKDMKIRISAPQERLYSTWIGGSILASLDTFRKMWVSKREYDEEGHRAVHRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIG9</accession>
    <name>A0A835GIG9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_016989</name>
        <name evidence="5" type="ORF">HW555_004290</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000822">
        <property type="protein sequence ID" value="KAH9630451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIG9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9630451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="254" mass="29070" checksum="B04C7BBC4DDF4951" modified="2021-09-29" version="1">MSEKHLQTGDALPPYGGKLRLFAMRFCPYAERTVLVMNAKNLQYDTVFVNLDHKPEWLLNYSPKGTVPALEYEEGKGIFDSNIINFYLDEKYPDVPLQSTDPLRRAEDKIIVELFAGVQSAFYTAAYNSQALQPNMVDTYHKGLEGLQDTLRARGTKFLHGETPGLVDYTLFPFLERFEALPLVGKPEFELVKSKYELLVNYIEAMKVVPAVKLYYLSPETHAKFIESRNKGDANYNMLDTSSVCCMRPRKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIP2</accession>
    <name>A0A835GIP2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIP2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000512">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000532">
        <property type="entry name" value="SLC (SoLute Carrier) homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="807"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="10"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="468"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="951" mass="104522" checksum="E33E7BDE86A933FC" modified="2021-09-29" version="1">MVFIIPQRYVLAVMALLAVANAYTMRVCLNLAITQMVKKVQTVTDDNYDPLICKDRYIIESNSTEARTTQGLILGSFYYGYILTHIPGGMLAERFGGKWVLGCGLLSTAICTFITPITVKMGGATALFILRVIEGFGEGPTMPALMAMLSKWAPKAERARIGAIVFGGAQIGNIAGSYFSGLIMHNGSWENVFYMFGGLGLAWFALWSVLCYSTPNTHPFISDSEKKFLNQNVDALIHTYSKKLDPIPWKALLRSVPLWALIIAGIGHDWGYFTMITDLPKYMTDVLKFNIKSTGILSALPYVAMWVASFFFAATGPGICIIMASYSGCDTTLAVFWFIFAMTLMGAYYSGMKINPLDITPNYAGTTTAMVNGIAAVSGIISPYLIGLLTPDSTLKQWRVAFWVCLGVLVFTNVIYVLFAKGEQLWWDDVKAHGYPAGWKHGDLPTRPKMTLTGWRRFLNKGMVVPQRYVLGIMGLFALGNSFTMRVCLSMTITQMVLHAETSEHIIGETCPDPNGVISNSTDDDNNTVSLIFTGRDRYDWDEATQGFLLSAFYYGYVATHLPGGLLAEKFGGKWTVGLGLLVTSVATVLTPWAVSVGGAVGLFIIRVIEGFGEGPVTPAFVLLLARWVPPAERSRFGAMIFGGAQVGNIFGPYISGILLADGGDWANVFYVFGGLGIIWFIFWALLCYSTPNSHPFISEKEKNFLNKNITASGLHKKLDPVPFKALLRSGPLWVLVMAAIGHDWGYFTMITDLPKYFSDVLKFNIKETGLMSALPYIAMYIFSFIFAGLCDLCVKKKWHTSSVPAIFIILASYSGCNRLAAVGLFIASMAFMGGFYSSVKINAMDIAPNYAGTCSAFVNGIAAISGIITPYLIGLLTPDWRVAFWTVFAVLVGTNAVYLIWGSGEPQWWDDVDKYGYPPNWKHGPLKKRAIDGEKKVVYPKHDHSPVSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ31</accession>
    <name>A0A835GJ31_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_005817</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="64"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="15">
        <location>
            <begin position="930"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="14">
        <location>
            <begin position="1162"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1471"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="15">
        <location>
            <begin position="1614"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="14">
        <location>
            <begin position="1768"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9416989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2078" mass="238688" checksum="A267A198B91B085A" modified="2021-09-29" version="1">MADRVTLSDFVWLKPIGKTEFDVPIAVKVLKSAGDKIEVKDHDGNVFSTSIQNVLKPLHSTSVQGVEDMITLGELQEYTILHNLHMRYSKQLIYTYTGSMLIAINPYEILPIYTMDQIHYYQKRSLGEIPPHIFAIGDNSYRELLDTASNQCIVISGESGAGKTESTKLLLQYLAAASGKHSWIEQQIQETNPILEAFGNAKTVRNDNSSRFGKYVNIYFSKKVTGLSADEKKRLELGRPEDYNYLNSGKMLTCDGRNDGLEFNDIRSAFKVLNFPDHEVWGTFSLLAAILHLGNLKIKSISSNNMEASEIPDSTAANRIANLLGVSKVKLCEALTRKTFVAHGEKVVSPLNASSAVDGRDALVKAIYGHIFEYIVEMINKTLFKEQQVTSGSVGILDIFGFENFDFNSFEQLCINYANENLQQFFVKHIFKLEQEQYAKEGIQWTNINYVDNQENLDVIGLKAMNLLSLIDEESRFPKGTDVTLLSKLNSNHSNKSCYITAKSSREYKFGIRHFAGDVSYTVQGFLDKNRDLLTADVKEMILDSSNEFLKNLFLTEYSPTQSGSRKTVSLSHQFKTSLDSLMKTLYACHPFFVRCIKPNEFKKPKIFDKALCVRQLRYAGLMETAKIRQAGYPIRYAYKDFVHRYRLVAPGIPPAEKTDCVSAAKKICAHVFTDDDYRFGHTKVFLKDYHDARLEELRHKVLITAVIKVQANARRFIYRNRFLRLRAAAILVQKTFRARGYRSRYLIMRRGYSRMQAAIRSRELRKTFINMRVFFRKIQAFCKGYLIRKLVREKGHVIKATLIQLDKERAEQIASGRSAESVGDSYEKKYTNMMRSIWFLKDVQSDNVEQNTSAIDDRYVDDVFGFLKDSATPGGTVRGTGFGVTTTAKPEISSVIPLQMQDMDDEPFDEFNFRKFAATYFLGNTTHQYSRRPLKHPLLDLPSPVDKMAAQALWITILRFMGDMAEPKYVDDKVDNVPVMTKLADTLGRAFQKSKEFDEYLQRDLSTNDRTKLISRTLKQRTKLDEEFMKNLMNDEVTSEMYSTWLNSRRSTNLEKLHFIIGHGIIRKELRDEIFCQLCKQLTNNPSKASHARGWILLSLCVGCFPPSEKFVKYLRAFLRDGPPGYAPYCEGRLVRTFKNGPRTQPPSWLELQATKTKKPILLTVTLMDESMKTVQSDSASNAEEICQQIAESIGLTDSFGFSLYITLYDKVLSLGSEAEHILDAISQCEQFAKEQGTPEKSAPWRLFFRKEVFTPWHNPGEDAVATNLIYHQVTKGVKYGEYRCNSEKDLAMIAAQQHYVEFGPTIDPNILRRVIVNYIPNQFLQSNDAALTKWEHLVTKAFESSSSIQSKIDPLRCKEDIVIFAKLKWPMLFSRFFEAIKLKGENINKDLVIIAVNWTGIYIVDQQEHILLEISYPEVTYVAYNADKDYDSIGRITIRTIQQEEFEFQSVDASEMSSLIIYMIDGLKRRSIYVVAQSDLQGYSDASSFLQFKKGDLIVLLQDSTGETLTNTTWGHGVCNGQEGLFPTEQVYILPTLEMPSNTILEVFKKGNINTEKKSFSQYNTIQRKRMHTLENYAKQHFRENHDINATYSRKSTLTTAKRSVAGDLWCHTREPLRKPLLQKLVGDEKSSKAAVSAFFGILKYMGDMPAPKARTVTEYTDEIFKTAVNDPNLRDEIYCQIMKQLTNNRIQLSEERGWELMWLVTGNFACGQTLLKELVDFLKTRPHPIAKDCLKRVFKTQKKGARLYPPYIVEVEAIQHRSMQIYHKVYFPDDTDEAFEVESSTKARDLCEQITGRLNLKNSDGFSLFVKIADKVFSVPENYYFFDFIHELVEWMKATRPVRGGALMQMNYQIFFMKKLWINTVPGKDKNADQIFYFPQELPKYLRGYHKTSKQDLAELAALVYRSRYGTDQTMLPQITQMLQDYIPSDMIRIQNNSQWKAAIQKAYMEQGSMTENEAKEQFLKKIYLLPTFGTAFFEVKQTSDPSYPRNGRYWNQQEWSLCYSSAESSKYFHYDVLVTHPFSQLSNWSSGNTFFHMTMGNFLRGTKILCETSLGYKMDDLISSYIAVLRKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJS2</accession>
    <name>A0A835GJS2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">MICAL-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_004760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJS2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF84">
        <property type="entry name" value="ALPHA ACTININ 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="11">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="12">
        <location>
            <begin position="648"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9418472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="98751" checksum="95CED693B82F2229" modified="2021-09-29" version="1">MSERRGTKALELWCKRLVKDCPEVHIDNMTTSWRNGIAFCALVHHFRPDLIDMSKLNPENIYENNKLAYSVAEKHLGIPALLDPEDMVENDVPDRLSILTYLSQFYQRLGHTVTTKVNESESKVSPQPASAETSAPIRFGKTGLDKCAACGLPVYLAQRLLVSHKLYHRRCFRCSKCSGHLNPKNFEIVEGSEFTCDSCKNEKTLSKYLNNNDHDQMGMLAFTDTVNETKSVSNEEPVIPKNKPRPQSILDKINMFEKNIEKDTNIENKISNISLKDNSISKSEELSTTSRSHCEADTQPTLISTTTKMEDEKISSNNTPEKVYKSNMEKFNFLQTQLAEDIRNDDYTKETVDVIKTSNKDKDCVNTIEHNTISVEDINDASSSVHEETSNVTDDNRIANSSSTVMEPPSLIEKSPETQPDQEISISVPPRRKKQNALEKALATAMKKEEETKLDSKEYPDHLNPFSDDEDEEVAPPKKVSTNPFGSSDEEDDDVPPIPQAPKPETTPVKRLIAVNPFWSDGEEPSSDEEETHNKSSMYRSSMATSTPNLPGSTPRRKKGKAPPPPPAISITEKSIGKSTPTLKKRRPAPTPPDSLSTLSGGCGSLERGINTSGMRSINSEGMEPLRYTIHMSCGRKTKGPAPGLPLPERREVKMQMSPEELQVQLDLLETQQLGLERQGVLIERMIRDKCEGDEADTVPQEEVEDLVIQLCELVNEKNDLFRKQTELMYIRRQQRLEQEQADIEHEIRIIQSRPAVNRIDADKAREEKLVLRLVEIVRMRDELVQQIDAERRRERQEDLAIAASIANKRAQRNSESNSSSMKSVEVIPTPKKNKVKDKVKKQLKKAKHTLISKKKEDSSERKEEKDKEKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJX3</accession>
    <name>A0A835GJX3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJX3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032011">
        <property type="entry name" value="DUF4794"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16042">
        <property type="entry name" value="DUF4794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032332573" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4794" evidence="3">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4794" evidence="3">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="197" mass="21607" checksum="0170CDE69FCFFC90" modified="2021-09-29" version="1">MKFLILSCVVIGALADLPRFRPARFRFQRQELAPTTTDSPTEPTTEESGPYPASGWKPAGEPFTLPTEEKAEKPADQYGAPADQYGAPDAPYPASGWKPQGQAFELPKQSPPATSYGVPDNTYGAPDSTEAPTTDNPQAERLEGPVEVQKSIGTYYVLLPDGRLQKVEFVTENDVQNMKYTARIQLRRPAPLLVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJZ4</accession>
    <name>A0A835GJZ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="35879" checksum="2D05880C0433D619" modified="2021-09-29" version="1">MKSAETSWMLVASSLAEKHDQRTYCDDVGCERKVRRSALVGPCMNSSAAVSGRIMQWLVMWCQVLLLAEGMHLMPQYYEPSTEVNCIEYATSNQNRIGRILKEGWHAQKPNPRKIIQKRSVTIPVQFSLTTEPMSRRMDDIISNIIPRGAHLLKEHAKLVQDINSLRQVVFISPFIEESKDYDDSIFHEIIETSPTSTNRPSSFKPYVSTTRPPISSTRPPMSSTKGSSIPIILLGGASQRQVVKSQPITFLKPTVSLVGTTISPLVKHPYPFVNPQRKPMKICMTSLPAMFTTTRRPPTFWDKLIDYFIPTRTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKD2</accession>
    <name>A0A835GKD2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menorin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the menorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKD2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF6">
        <property type="entry name" value="CONSERVED PLASMA MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Menorin-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="277" mass="30085" checksum="8BDECC8F9279A753" modified="2021-09-29" version="1">MAIVVRSAEEESMKNLTTITWAHAVNNKTYLQASLASSICMLEADIVIGTVIGKDGPAIPIMAHPPATSSDLSLAEFLETVSQHNLKESNPTSKKGVKLDFKSIEAYEESQELIGRYQAQGLPIWLNADILPGPVDATTKPVDPVKFLKLGSKHACAVLSVGWTTNYGGNITEGEYTSEQIGTMLRMINENHINQTVTFPVRAGLAANSQPVLLDLLRETSSLNSTMTVWSSEGDHVEVDRLRALILTVGLERTYLDVPQELAGKLHLPPPDAKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKJ0</accession>
    <name>A0A835GKJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L antigen family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_004004</name>
        <name evidence="9" type="ORF">HW555_004737</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9630713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="78" mass="8847" checksum="85FE89DB6B0875E4" modified="2021-09-29" version="1">MNISLTIPFPSPESASLTRDVLNVDKELKRSGVQRKLETNAENLVITFHGRDLKKLRVAVNSMIQNIILVVKTIEQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKN7</accession>
    <name>A0A835GKN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WASP family protein member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1559" mass="171179" checksum="FCEB709CC0D290C1" modified="2021-09-29" version="1">MAEGSLSDFAARKVQYTASHPLKKGLFTPDTRPSSIRKLYEKATIDRLSASILDQLRRDSQHSPYLLCTPVLSTKRRRIYQKVDVEIETRIPSVVEQLRKWTSKEAVGDVTALPDASMRIASSVTLTPDELSECGSGDDEPIDHRLPSPDEQLRIIASKFPPEVVAIDTSGKFFDRMCSSRKSLHLESSTGETDTVKRRTRTRKPRGKRRNTISGTDQKELREAIAGDTSNAAASEEIEDSNTVIRSKSSDLLKKSPIDPVTKKGHFNSLKQWGKNRLKLIGRSPSASRDNFKDTSKSEKAKDSKSPPRQVELVQDSVTMRKKRPGDEDRRTHQRCASYSSSEKSIGMPSIVQPNVATINTGVKLRGTSVQRRLRRSGTAKDEPHSSSGNWSASSESGRTSIGSEITTTTVPPKSTTSAATSNNSLNAHHGPPSSIISRRRFLNTSGSGSVTSEGTLTPDIIHDLHEDLETSSEFSCDTEGYYTSFHMDSGLKTLKEEEITPSTPLHTSNALSNSSNSQNMTAENEYELFGKGSTSTTTSSAGTVCTTLMAAGSDRSLVIGPTVPERKSSLAKMSRNRSANAHSANTSLDRSINSSFSKSPFSSLRYNPVRYNDKPAYNNSSPEINEATPPTITITRNVGNHTEITAVAEVHTETELESAKKSTGTSSPDSGHNTSSSPIEDSVSSAHGKNSLSEQDYSESSDLEGTERIERIRYKTTINSSRIPSMCVITPSNSDDESESSNKDSDIVIKAQTELSKVASRPKLDLPIEEKLKEVKTPTELTKPSNKGIQIKSSLQPFNSLMCKLKGVLPHKLSNKKSPVSKEPELTEDFYDTGDYVTIADVKNNNQKLSLNRGIYGNSDVVKKNLQTVLSGKLPETEYVSLNELPNCLSGSKDYLEHSLEDKPSAALDDVQIKGAKVTLDSQGQVIYSSDTLKRRKGAHTTFEPGPFVQEIKPTTTVIQREIADVVQVVDETDFPYEPPPPSSKPTSPQLGKMIIKAPTAPDGPMTTEFITLPTPKPSTIITATPITETPVLSNQQHSKITKKPQDIPRVVEAITRTGAYVNIHDAEGVSLSPTKDDLADYRHSSADKPYLNIPPNVIQDKGPTVDLNAINPTLHRYHTAHLRGRHGIIDYDNSNAAQRDQPKFWTLPKRSNLESNAPQRSASNYGMKIAPVNLPAPEMLTRAQGSTNTNDESIKISPIDPRTSGHFKSSTPSNKENVVDLGTKLLSPVKSTMTNEELYAVIHKSKKKLNIKDTTERSESPALSTISLSPVSSETSLYTKGTQRHPETGYLGDPRNRMSWSPSEKQNIIPISGPIYGAQKQETNCADRYGPMSQTSRLDFKKLLLQHSVKLNTLPQNKTNKLSAVEQLKLSREKPQTLPSQVANRSQVNILDLSGSPKTYTHRKWRFASPRSDVLSTPIPEAYNEDENSNSSGEKHEVSVETPPSKTVPIVTNQHFGARRNLIPINETTLEIERNFPLSTDQGVYPLITDFIRSQGLSRTEIMQAKRAEFFNTCPESSPPKLTSFKSPNAAGPSVNSRSKTSPERGKVSPTTLETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKY2</accession>
    <name>A0A835GKY2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKY2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="434" mass="50803" checksum="0655456F5643E362" modified="2021-09-29" version="1">MDKNSSTDSNISLDSLETQFKRKKSVKGRITDEDVDTILVPFYEKDVLIKVPKDQKRKQNNTGNRYLRANEKLKKEPSQTSYLVNREKETKHKRTTYLEMFRKQFSPNQIDKKKDKNEIRSLSPEFGDTERESIGDDANNPIPEFYNTESYNEMYYEKLLCRDLENYIDNSFEDQEEELRFTDDMVCKPEDICDDGPDNLKSVSEVTNPRRNTRRATIEPMTNVKLGGLGPDLEQIRPRLERARSLQRYSEKVRMENRLKIYKKTCQTQPEKKVERETSAKQKESRKEPAKKEQQEDVSLSYLVNKSINEKGNKPKRNPYFKSKSADVQRIRERNAEKEKLQKELTAKKKEMVDQKLDSKQKVETKPDKGKLKQKSSSRNMGINTESSSEVSPVQISFMVNVGGVRQSSALQSLEEKHRMYQEQVKAFMENNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL06</accession>
    <name>A0A835GL06_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL06"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="488" mass="53940" checksum="4C82E2038EA372D8" modified="2021-09-29" version="1">MNPWQQGQGNPQQQYYPNVGFCNSAPQSFGNPMPMPGMPTMGYPGPQPGGAPGYPQVSQGYPQQQNSPYPRQQVNQGYPNSAQGYPGQGYPQTAQAGYPQQAQQGYAQPAQSSYPVQGQGNPGYPQSGPGYPQSSPGYPQSSPGYPQTNQYQGQQQYGQSHASQQAYNVAMPKTKPTVVPANPFDPREDAAVLRKAMKGFGTDEKAIIHVLARRTNEQRLRIAFEFKTLYGKDLVADLKSETSGKFEDLLVALMTPLPQFYCKELHDAIAGIGTDEDVLIEVMCTMSNHEINVIKQTYTAMYGNLLEDDLRGDTSGNFKRLMTSLSMGNRSEDFHVDAEKAREDARSLLQAGELRLGTDESVFNAVLCSRSFPQLKAIFQEYQYLTGHDIDDAIKAEFSGDLEKALRAIVKSVRNKPMFFAERLHKSMKGLGTNDRQLIRIMVTRSEIDLGDISDAFQAKYGETLQSWIEGDCSGHYKKGLLALLGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMN5</accession>
    <name>A0A835GMN5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoglycolate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_014533</name>
        <name evidence="5" type="ORF">HW555_004331</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000710">
        <property type="protein sequence ID" value="KAH9632449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMN5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9632449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37225" checksum="2DD327351DA4922A" modified="2021-09-29" version="1">MIRFLNQIQRIHNFCYSNVIVSNQLRGFSTSDTMFKSAVFNLKDASKDQVQDFLNSFDTVLTDCDGVLWIDNNAIPGSADAMNYFRKLGKKIFYVTNNSTKIRSEFASKATQLGFIASQEEILSTAYLVAHYLKGIGFTKKVYLLGSNGIGEELKAVGVRHIGVGPDHVKPDFKSMQPSELDPEVGAVVVGFDEHVSYPKFMKAASYLASEECLFIATNTDERFPKGGSIVVPGTGTLVRAVETCSERKALVLGKPHNYVRKYLESCGLNPARTLMIGDRCNTDIELGVRCGFQTLLVLSGVTSPKDLEKLRSEKTPPLPDVVLPKLGDLLSLVYDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMP3</accession>
    <name>A0A835GMP3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methyltransferase-like protein 17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50659" checksum="FDC5D2A341EBF85D" modified="2021-09-29" version="1">MFRKLRIKYFTSVYANYTTRVAVDPSLKENFDAKVFKPRKHPGTNRIKIAAIPPDIQKAIKLILDDAGAKAYNQESIKLSNYIRSRHLPPEDGEIDEKAQKFHNAISKQVYSSIDRELSPEEAEVCEKKIQNKVFSALKKNVYRWGNIAYDKPTSLQYLMSRAAPEYAVLLRIFDEIKKFNPDYKPRSFFDFGSGVGTGTWAVNHFWKNDIFEYFCVDTSPTMHDLARLILCHGRDNVEMPLKGFFQRQFLPASSDLKYSIVLSAYSLFELPSLKSRLETIQKLWNKTEDYLIIVEHGSNAGFQVVNEAREFVLNLKGKKGKEGYAFSPCPNDNICPRYLEHETPCNFLMKYESLPYAGKAEVFADLFSYVILKKGVRSPDDPQWPRIVRAPIVRSKHTICKLCTAQGELKEVIFSKAKYDQTTYRCARSCNWGDLLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNG8</accession>
    <name>A0A835GNG8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNG8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027831">
        <property type="entry name" value="DUF4485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14846">
        <property type="entry name" value="DUF4485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4485" evidence="2">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="579" mass="67249" checksum="C9C60080E2443FEB" modified="2021-09-29" version="1">MDENDIVNLDVEFKRYLQLLRPYLGQLVDQNVIKICDTWIQRLSDCKENEKVLRNKYVFVLCYQLARGVLDLPFLNQPPDELQPLSDDLHSESSTEEEYLVINSEEPRTKVIFDNKNQSRSETDYFTQEFDKGTESLTSTELPQPIIKENYPSSTGKNVFCYTCPEVRHHMTDHSEEYEYRANNLVKKLREIKMQNMLLQKELVALKDESKNLKQDELAYEGVTKVDNATSAFIRTNDSNITLKSLKTQLQEVQQSRNNLIQTINTLQDELDRVNEMKRNEQEDLEAKHKLELIKARTAAREETKVFFEKKIEELRQTYEETLNKMQDSASYKVQDMNKLKDGIIEEKDKLLEAKDVEIRRLKTQLEDQKNNLHTMLNKFMEKSNDEGSCDAMKLRAQQLETRLNKLEKTKAKCIKMYETKLAQLQREKQLAECSLQLQLVRQRAQVVNEMTDENQAELTTSLDKLETKYKDIVANVQATAIQRRMQDQLALESIFQAACGIHEQNQMPFPKPARNQNQSYDSEISSLLRGNKVGTVIVGGNKSFGEDSLTGGFCLNGERMGELFERVYIPQRDNGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNP4</accession>
    <name>A0A835GNP4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNP4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF44">
        <property type="entry name" value="ODORANT RECEPTOR 13A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="390" mass="43944" checksum="1BA4FD0091EF3420" modified="2021-09-29" version="1">MASQFALISKISGDNFLENIRVVPVDLMFFQDVVKMLIAIFRRSELKEMILEIGELWPKDLDSGDPKADILKSWIRRTKTLLDMFFIFAITNLALFEVIPFLISVFNLCNGNEVYLFPFQPPNFWDVDSFCTYILIYLWELAGTIPCQMCLYLPFDLTIVILTSNVSALLRLLQVDLENAIKIHDEDKHLKKNINVTDPESYENVRTLVMVHQKLLRISDQLSSVFGLVIFIHVAFAALEICFFGFLTLVYGGVADTIANLLTVFNAVFTIFLLSLSGQFLCDTSSQVADAAYQSYWFESDVKVKKLILFIIIRAQRPSYLSALGFSQLTLKSFSKVKVASSRGGIPISPVRDEGRGALSRRRSRHLGLRWRAGCAGGGGGAAHACYCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNR8</accession>
    <name>A0A835GNR8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNR8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="523" mass="58800" checksum="B4ED3DE8CE239A3B" modified="2021-09-29" version="1">MPSTHLNLREDDVVRLALEFLHNRDLHITQLSLERETGVINGNFADDVLFLRQLILDGQWDDVLEFIQPLSALKAFEADKFNYAILRHKYIELLCIRSEIKAYNNVENIVDEVVKVLSDLEKLAPSKEEYSNLCLLLTLPSITDHAQFKKWNPSNARVQCFREVYPLVEQFLPCDKKSGGLVSKCAKNDRLMQLLIKGILYESCVNYCQAKATGSKEAQSNEVNFSRLLDGSGFDESDLSLLSWLQSIPAETFSVPFEQRMLNVDVEKLERPSLHTSWTEHMLVTPIKPRTFPHLAMPFRRPRSAADAMTRSLRPLPDGAPRHPAVMALSAIDYGPSSSCFAGFHLTGIKGSRLMNTSVDRLFDSKNAESIFNGLNESLKTIDETLKPIGEYTGSSKTNDSSVGASNATTPEHRGQDYSASTSISNTAASTERSSLAERTPQQAEAAMLPGADGDFRRELLKEYQIQKQRECDDYLRNLCSSDLRQQKMVEQIEDVASAFPSAVKNPQQIIADKNREQSPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPC3</accession>
    <name>A0A835GPC3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein mesh</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_002140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMOP_dom"/>
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        <property type="entry name" value="C8-3_MUC4"/>
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    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="VWF_type-D"/>
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    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032402287" description="Protein mesh" evidence="9">
        <location>
            <begin position="19"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1503"/>
            <end position="1527"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="418"/>
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        <location>
            <begin position="650"/>
            <end position="801"/>
        </location>
    </feature>
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        <location>
            <begin position="814"/>
            <end position="1022"/>
        </location>
    </feature>
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        <location>
            <begin position="1113"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1235"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1549"/>
            <end position="1629"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="1235"/>
            <end position="1254"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="1301"/>
            <end position="1311"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="1350"/>
            <end position="1366"/>
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            <begin position="1409"/>
            <end position="1421"/>
        </location>
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            <begin position="1430"/>
            <end position="1441"/>
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            <begin position="1549"/>
            <end position="1568"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="1585"/>
            <end position="1602"/>
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    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF9422119.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1629" mass="185727" checksum="352EE4044B0B1A47" modified="2021-09-29" version="1">MGVKVIALIALLVVSVYGQDVTVSDNEVTKEVVVDNLFSEDTTVLETVTEPTKDEVVEEANPVEIISATDDLQVRSGKYQLNDGLVGEEPISLDAVNFDSNNDAGESEKQLLSPGTTQVTNNEYAHIDGRVLPDTNYQNNGQPYVITATRLAQIRGNFMYWFYDMGGNENIGDYQRDIHTSTPQIHKNFNFQLPFFGFRFNYTRLSMNGYIYFSDPPDHYTYPLSFPMRDWPDVNDPSFIGIFFSKCRIGSLNQNDPDQRRPGVYFRMDRDLQTRTDQLGVEMRERLTWDIREGVIGSETFFPKHAITITWKNMSFSGGIDNSLFRTNTFQMVLATDEVFTYAIFNYLEINWSSHTEAGGDTTTGEGGVPAYIGFNAGNGTQSYEYKPYSQASVLRDLTGRGWANGFPGRHIFRIDEKILMGTCNKDIDGANLPLMFAPESGNMLGGTIVNITGPCFNPTDRITCRFDTESVIGAVVDSNRAICVQPRFWHNGYARFEIAINNEPYKWKGKYFVETPATAAEKIFFTDNSVHERYPPEIRITWDRFNLTTNLNVQLQISLWGYKEITIRPQLEYIDIIEMGVANTGEYVINPQNFRNRDNFMHNDMQFGFLQINLTTPEVFKGVSISPVLWSRPIPLGWYFAPQWERLHGSRWPNALCNNWLRTDRFLKNFASQVWVCPCTLEHALLDKGRFMPDLDCDKDTNPTCRYHWGGIHCVRSGAPSAEGSGQQCCYDKNGFLMLSYDQMWGSRPSRAHDFGFTPYNEANKVPSLSHWFHDMIPFYQCCLWQEEQAVGCETFRFERRPSQDCVAYQSPGVAGIFGDPHIVTFDDLQYTFNGKGEYVLVRVDHPQLKLDVQGRFEQVPRNIHGRVNATHLTSVVAASNNSVPIEVRLRPQHAQWRYRLDVFADNKRVYFDRPALRVQYFPGVTVYQPMYLLNQSEIVIMFSSGAGVEIVENKGFMSARVYLPWTYMNQTRGLFGNWSLDINDDFTRPDGTRVNVDLNNFQTAHRDFAQHWQLTDREQKDIGVAMFFREYGRTAAYYNDNQFVPNYIREPADFLPTNRSQDVARAIEICQDSYQCRYDYGMTLNRDMAEFTKNYLASITNIKEQNARRVISCGILETPRFGRKSNFFFTPGTRVNFECNQDFILIGDKRRVCEDNGRWNLPDYGYTECLRNQEYSQRALFLTWGVILAVILPLGLLICLLWFWCWYKPRSEGKDGFRFEDIPRSKSASRLNLRSASMGNLTDTMKSSTLRSTDSDKKAKLPETPTEETPITRSAPLTRAAPPPPQDGDSSGIGYPDSNKSDSNKSDKSNKKRRAYDKTYRTNEPIPNAPNEEFPEKLWDLSEEDLLSITSPSDTESNRDSTLTRPAKDIEYLSRPRQLGRRALPSDSGYSTKDSEDPYSPKYEGQYSPIPSTYSPTYSEIYSPPISPTSDSPRSTFNNPGLPDPPKSAPADSIQTFTMPPQKGKSMETLIDPPISEMPTMSPRSTMNLGKQEYSSRTLGATWGIISAIMIPIVIVLICIGWRLLLRKKAEEKEERDFMNIKPLDPEESLRINSDDESIPYKKDTSDDTPEPTEPVKVEDNPEPSPEPMPAPIPPAPPVVGIPYPAYGMPYDPSRQARPYGGETEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPJ1</accession>
    <name>A0A835GPJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="403" mass="43662" checksum="05DB131DF93B1FD8" modified="2021-09-29" version="1">MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSNNKLYQYASTDMDKVLLKYTEYNEPHESLTNRNIIEALTKKEHKNGVMSPDSPEAEPEYNLTPRTEAKYSKIDEEFQMMMQRNQLNGSRVGVGVAGSNYNLPVSVPVGNYDQTLLQASPQMHTSISPRPSSSETDSVYPSGGMLEMSNGYPGSGSPLDAGCTPSPSPGPAPSPHRHGHKSHGHAPPPHHSPRHNNLRVVIPSSMPPPQDDISYAGETPLGYSGLGNFGPQDFSINSDMGIGLTWGAHQLQTLQHNSSSLPVMGGGGTPPPAASPSNVKIKAEPVSPPRAPDHLHRAPPPQPAPQPAHLSGVIDGSVSSSNMGSPAGQDMRHSAVPLDYEQPHTKRPRIEGWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPP8</accession>
    <name>A0A835GPP8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="270" mass="30822" checksum="3F34745DFD088F40" modified="2021-09-29" version="1">MADSNSNSYDIINNYSPKIEVDSESEREYSRRDQNAKCKLYWTTENTIKLIETMEKECRELWDAKNPLNRDRNTRQAKLEYLAEVIGTTSEEISRKVHNLRSQFNNELRKIKRGQVVRSGWEYFDALSFLMRTPSAEALETVDAVNLELAEFQADEEEEFGAAARAHVALLASNNSSNGSPSRRLHKPLRVAASAPLPLPPSANPLMWPEEPTPRIRPGINADECQIFGDFVASELRTLRSHESRKRLKRMIQKAILQIGEEEDVNMISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPS0</accession>
    <name>A0A835GPS0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquilin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ataxin-1 interacting ubiquitin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ataxin-1 ubiquitin-like-interacting protein A1U</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Connexin43-interacting protein of 75 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquilin-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HF086_005884</name>
        <name evidence="20" type="ORF">HW555_001838</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homooligomer. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site. Interacts (via UBA domain) with ubiquitin and with polyubiquitin chains. Interacts (via ubiquitin-like domain) with PSMD2 and PSMD4, regulatory subunits of the 26S proteasome. Interacts with ATXN1/SCA1; interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding. Interacts with HERPUD1. Interacts (via ubiquitin-like domain) with UBQLN1 (via UBA domain). Interacts with UBQLN2. Interacts (via STI1 1 and 2 domains) with MAP1LC3A/B/C. Interacts with BAG6. Interacts with MRE11 (when ubiquitinated); interaction with ubiquitinated MRE11 leads to MRE11 removal from chromatin. Interacts with DESI1/POST; leading to nuclear export. Interacts with BCL2A1 and BCL2L10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000683">
        <property type="protein sequence ID" value="KAH9632829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPS0"/>
    <dbReference type="OrthoDB" id="9450922at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01808">
        <property type="entry name" value="Ubl_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000003">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000095">
        <property type="entry name" value="Ubiquilin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000077">
        <property type="entry name" value="Ubiquilin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="19">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9422440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9632829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="522" mass="56614" checksum="C6803290D82E7318" modified="2021-09-29" version="1">MAEGQDEPKKITITVKTPKEKQQVEIDEDADVKKLKEVLSPKFSAEPEQLCLIFAGKILNDADTLKQHNIKDGLTVHLVIKTPPRPEPEGATRRPPADVGATPFGLNSLGGLAGLESLGLGQSTFMDLQARMQQELLSNPDMLRQVLDNPLVQQMMNDPENMRTLITSNPQMQDLMARNPEISHMLNNPELLRQTMELARNPAMLQELMRSHDRALSNLESIPGGYNALQRMYRDIQEPMLNVASSMAGNPFSGLVDNSDGTNPQQGAENRQPLPNPWQRGGGGGGGAAGTGGTGPASAGPGLINTPGMQSLLQQMSENPRLVQSMLSAPYTNSMLQALAADPDMASQLINQNPMFANNPQLQEQIRTMMPQMLAQLQNPEMQQMMSNPQALNALLQIQQGLEQLRTAAPSLVGNLGLGVGNATATPTTTPPAPAAPPNAPPRQQQNSELFTQFMQRMMSAMANNQTNSSQPPEQRYSQQLEQLTAMGFLNREANLQALIATFGDVNAAVERLLALGQLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQB6</accession>
    <name>A0A835GQB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035014">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052651">
        <property type="entry name" value="WDR81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="323"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="2014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2014" mass="227742" checksum="4335FD772927C36A" modified="2021-09-29" version="1" fragment="single">MDNIVKELGISNKNIFPTASPGLFSVVVHTAWLKKWIKNIEIDTSLNNVDFTLQPGESVPYPWRKIFVRVLNKKVSKVLPLPRYKLNENTNETPLTFSQLLQYVSQSNQRTLWKEAYKKYCQNNDSSKESTIVNLLEHDQLMSEVVLRLYGCNIIRVKCDGAGKHIEYKEIIPNKHVLKMYETHGNLLAAMFTIETDSNFYVIYRAQYENTLLDCLNFSPNLIDMNYSRGLFIVYQLLNLSKAMSDRGLSLGMLTLLDIYLSENLWLQVLPMITNNIHCLDASLIIEHNRSKQTTPAISQGPPGKRGEEWCWRKEAVQLEKLCMLWVRGRISNLDYLLHLNMLAGRAANDPQAHFMVPWVTDFSSRCGRNWRDLSKSKYRLNKGDRQLDMTYDVSSCTDQIPHHVSDALSDITCYVYLARRTPKEVLCKYVRNKWVPAEYPASIQRMQEWTPDECIPEFYTDPTVFKSIHEDLPDLGIPSWATCVEDFITKHREALESAASVKAKNVCLSLVDGHTRIRRGGAVQLLTAPHPPRASRALPPAPPRLHWTAPKDAKKSLRNDSSDDVSDDEEESTSLPQHVSRLNVPPQRVRSRHKSSSRARSLSKSQGLEDSQTVPIEGRASSHSRHYRVQRSELGKGVIYLPKEFNPQDMRQDSTVSSKEGSDDTAFTNHMFLASYDQNYLKKFTQDAHLESVLKERKNRTFNTRYTTDAAIYKQFVTESRRQDMLVIGCLIVEIFLHSYMRPLRTATDNFLERYNNCRTVLKYNFNALPRSVSYIASLLLNVQPLSLSYKNELTPKKEEPMKKILVTDKGLPAPTPAQLLQPLLMQHLIPFPQSFNILYKLLNTLHEYELTSTELNILYTYECDGVQCEKYQNVDKTKLYFNQKIAEGKIQACATHLEVLLNQVNCYNQFDVLDIFLSHYIELLQNKDTSVLAAWYLFDTVSKALGPAETRKKLLKHILNLYEDDDFAVDKPDQHKLTDVDGTLAGGVSNKQKFVKLYHNIFLLQLMVRLGLQCFLDNFTQHLVEAVGGYKDATEEAGSPGHLCHNKALSSKKPRYSDDNVKNALSSNTDIFSPDTSYGSEHVTTPGVEKTETHEGLKEKDSDNRSENELFHFETDKDRLPSRSSRSKSPAESIDSYNSNNQDNIHTPSPSIDHVSPISTKYFTAAQKEPNQTLHRDQNHEAVTPSNKPMSPTIEIPTKPMFTSYLHFAEEDDSEVELRRKSNDPQINLELGRHMDRSAKGSRSMNDEDFQGFKDPNTSKISDMSSESLIWLAHRLGPVLTCRYITRNLLKMLTLCYIGKDNLAPWDSDDRDEFDEISVVSSRVVGDRNAMKVIKCLTSIVAMYGEQLIIFQYLPHMGELIASCRRRLSAPLEGGVVACLQLIKYLLPHMSDVKLMEQLQDTFLKSILQPALRLASTTRCSYPSGAAARSSLTRKLLDALHVLALRIGPEMTRRHLCVPALQRFFLAFDKATGKIDNWPKQEETAPEKLLEQEPPDCKPEGFLEICRDGTTAEWRVQDGRVVRADIPDLACTPPDIAEHPHDTTRLTAQEELLMVFDEELAYRAYTTFVKSIGAETMERCLKNVDTVRALCRNYEQNHRITSPLQIRPDKRVQLSFSDEPLSHKANSSSKSDVVMDHISSSNSFGSNVTLVGNRIDVASDACDVGSGAHAHGFDVVAYKTDNGIKSNRHLRGDWLIYWEHEIGRPDKETRFNLKQIKLQTFVGHTHSVKSIHCLDNENSFMSGSKDKTVRLWSLRNQGDGNATSQCNWTYSGHKKGVLSLTFLESLRLAVSTDSVVHIWDPFMESVVSQLDSLKSPVSIVRTLAGPSAAVLAATTDATLRVIDARTPHTSHELKLPMSATTFIRCMCVSSSGGWAACGLASGHVAVTDLRTGLTIAAWKAHDGEVLRLATVDEHRLLSSGLDQVTALWRPDDGELIAHLKGSTEPVHCLSVYYKELISGTTNNRIGVHTSLSQDASFSSTKLRSDTFRGVLTCMAVLPLNRLLLLASDNGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQF7</accession>
    <name>A0A835GQF7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucocorticoid-induced transcript 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_007988</name>
        <name evidence="3" type="ORF">HW555_002808</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000062">
        <property type="protein sequence ID" value="KAH9644900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQF7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026642">
        <property type="entry name" value="Glcci1/FAM117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972">
        <property type="entry name" value="AGAP011572-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972:SF8">
        <property type="entry name" value="GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15388">
        <property type="entry name" value="FAM117"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9644900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35175" checksum="C461A000AE66D36B" modified="2021-09-29" version="1">MSGRVRKQSDCPVSKQGPMRATLPVSSVMKSGGLKKNASNSPTLSPTNPWRRISPDHALSGQRSPGAVNYKGKSRFGASVIRRTASLDTLYHKGQWSRDYYQHASQLQIDKSTQTDDGGGASGRSSRSSDDDKLDRFLRSRLQRPHKPSASGDYSSHSMSTALWSRFGGSSVPLRAARSSVEGLNQEIERLVLQPASGTQTPHLDRLRDKVTPEGHRAPLAELLRRSVNTQTPHDLCHTAHSSGGSVCSSPDLDGSKLGTSPQINRFLAREPPDGCEKVNLKAGEGTSSDSVSVMKPTVPGFTLRPSLGSAFQPLQPTTPPSPPAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQG0</accession>
    <name>A0A835GQG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWF19-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="391"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="522"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9422940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="71482" checksum="A7AF40A438E26F8C" modified="2021-09-29" version="1">MNEKQKKSKHSKSHKSKDRERRKKKSRRHSTSSSSSSGSESDEWVEQQTRQTNAAQREDWMSMTGMLKTYTKEDIKPKREEKDKKNIDSYNPGTSSRELNPYWKNGGTGVPETPESFRKSRPFIKPSDDDDDYYSSKPKSSYSSSTTSYSSRKSQEKQQDYYKDQKYSDRDPYRRSSNWRKQTNEQKELESFAQKSKEEIVMPSHKIDTAKPHVPEDKPKDTKYLSDEKMNKLAAKIVKAEILGDEKLVTELKTKLEAARKYRKENPDAGAEEEDDRVMLIATSSSGSSRPLTSSSEKGDPRSKSGKRKAQTHVSGERTKYFGDDDKYNLAEMFQQEKYGNNYNDEAELAKLAAKHKNPNDDLEDIFMDNISRNRDAAKESENERSRAISQHIKMERTLEGCEHCVDSKNMLKHLMVSCGNRVYVALPARVSLVPDHCIITTVQHATCVTSIDEDVWEEIMNYRKALTQFYNSQGKDVVFFETATRLNRYPHMVINCVPLPRDVGDMAAIYFKKALLECEAEWSMNKKVVDLKGKNIRKGIPKGLPYFWIDFGMDPGFAHVIEDQQLFPKNFAEEIIGGILDLDHSLWKKPRKENGESQRRKVMNFVKEWKPFDPFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSW5</accession>
    <name>A0A835GSW5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSW5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="19435" checksum="BEB1D0AE25BE320C" modified="2021-09-29" version="1" fragment="single">FVVQPKRHVFSIKSSGRVDGEVLNPLQSCWAVLHRKHDQRMKSFMVLCLFGLAAVAMARPDGSTYTDRYDNINLDEILGNRRLLTPYIKCILEEGKCTPDGKELKSHIREALEQNCAKCTDAQRNGTRRVLGHLINNEEESWNRLKAKYDPQSKYTVKYELELRKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT93</accession>
    <name>A0A835GT93_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein wntless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HW555_001224</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BAW_Kor-Di-RS1</strain>
            <tissue evidence="25">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Postsynaptic cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynaptic cell membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the wntless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032352063" description="Protein wntless" evidence="22">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="24">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="23">
        <location>
            <begin position="206"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF9423415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="524" mass="60468" checksum="ED357626CAB477F5" modified="2021-09-29" version="1">MLCQLTCFLIGGLVAPMPANAQIILATVCRDTSTMKNDTTNWYYSRGKGACKKIDLNEPHYDLSETDIVFAFQMPGPREGMILDYSRWQQNLIGVLQVDIKYHSQIEMLPRSTITIDARLAYRNKGDPEDVWKFYTKSVEKRNLDCDIDLKSEEYLYNCSAIPLFELGSLYHDYYLLNVRLPVDSPDMNSGIGHIQDMWLTVINQNGGFTRVWLYLKTAFFPCIIGILVWFWRRIHILQRKPVLLEKMLLSLGLALCLLNMPIEYLTLHYDLPFMLLLSDIRQGLFYATLFSFWLVFAGEHMLIQDASAQSSVKQYWRHLSAVVLGCISLFIFDMCERGVQLRNPFYSIWVTDLGTNLALTFIILAGISAGVYFLFLCYMIWQVFTNISYKRQSLPTMCSVRRLHYEGIIYRFKFLMLATLLCAALTVIGFILGQVAEGQWKWDESIELEYTSAFFTGVYGMWNIYIFALLVLYAPSHKKWPVVENTADTQNLSEEMEFSPLPSERASSEISSLTSFIRKTTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU27</accession>
    <name>A0A835GU27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9422969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="532" mass="59494" checksum="AD50D557369C4A74" modified="2021-09-29" version="1">MDFSSRNPATSNALNLAARNNDVANVERLLQKINPNCVDNRGWTCLHEAAYNDNYDCVLLILKNSRCRPFAETHEGHTALYLACKNKCSLKTVTALLNSADDIANYGSTEGVTPLHIASSQGSVQLIELLIEYGAMIDVQDFDGDTPLHDAVLAMQNEALVTLLYAGADPEIKNDPGCFTPFHLACCRGYFPNVETLFPFITDINQVTSSGDSPLTLAVQGLNDDIVYFLLNNGADPHIKNKSGEMAVDIALSIGSSPEVFKVLLSVTDSSKLNRNIIFNACKPHNFNSEILEILLSSDLGPEFFSFYESYQKRIDMLDEQKTIYKTNAPLNSYLNICGYIYKKSPDKFREFFYLFLMRGVEVNACDVSVCPPLVHAHLVNGSCFHEVFKILMEHGCNVDYNSASEWTSDYCFPDVFYSALNFFPISLPILLQYSILCEPEVILQTSLSKGQLGLIPPQVQQELLQMLDSNTQGITVESLSYHVPSLKHISRIRIRAMIRNVKGGIKSTQQFFSILDSLPIPKIMKNYIRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXK1</accession>
    <name>A0A835KXK1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000521">
        <property type="protein sequence ID" value="KAF9406996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXK1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="230" mass="25146" checksum="F2C9140849E90CF7" modified="2021-09-29" version="1">MMPTFERRFSTGDNNRPNVLVKQICIDTMVLIFTEIRIQPQPSNPWANLLSTAEKGISTVGKGLSLLETKMQERNRKITNTIEWIPSTGSDVGTLRHRAFVAGREGWDGSPICVIRAHHNGEFVPGKLAIKHQAAYIPHAGREIPVHNFEVLCASSHAVRWLPSSNGQVPVGAIPAGNTHNGEPLYIGRVTHMGSITPGKVHPSHGCCYISFSGAEVAHKSYDVLCRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXX8</accession>
    <name>A0A835KXX8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000880">
        <property type="protein sequence ID" value="KAF9404794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXX8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01092">
        <property type="entry name" value="APP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF10">
        <property type="entry name" value="DIPEPTIDASE YKVY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="23660" checksum="33341838C03E54B2" modified="2021-09-29" version="1">MDAGNWADVALEIGFKAIKEGVKEQEILAEIEYQLKRQGISQMSFDTLVLTGKNAASPHGNPGSTAVAKHDLVLFDLGVVYNGYCSDVTRTVAYKQPTDFQNDIYSIVLEAQLKAMDAVKPGITAGELDEIARGVISGYGYGEYFNHRLGHGIGTTVHEFPSLVTGNDLVIEEGMCFSIEPGIYIPGKVGVRIEDCLHVTKTGCEAFTKTPKELTIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYH3</accession>
    <name>A0A835KYH3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_012206</name>
        <name evidence="13" type="ORF">HW555_011850</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000590">
        <property type="protein sequence ID" value="KAH9634792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYH3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="100"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9408493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9634792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="721" mass="81077" checksum="6D021A287B37CEAB" modified="2021-09-29" version="1">MAAYVNRTISMMAGDGPHNVSMLNNGTVRVNMSNVDSPLQIFVRAKKKINDIFVEIDDYVKDAVTFMHAVTGENGIATPQDLANVEAYISKVQAIREVLKRDHMKVAFFGRTSNGKSTVINAMLHDKILPSGIGHTTNCFLQVEGSDNDEAFLRTEGSEEKLNVQSVSQLGHALCASRLQECSLVHVYWPRELCALLRDDVVLVDSPGVDVTPNLDEWIDKYCLDADVFVLVANAESTLMVTEKNFFHKVSTKISQPNIFILNNRWDASASEPEYLDQVRTQHANRCVDFLSRELRVCSPKEAEERIFFISAKEALLTRMREREKPVSSPILAEGHQVRYFEFVDFERKFEECISKSAVRTKFAQHSRRGKNIAAEVMAALEVVSLTLSQEIRRLSALVDEYDTPFRTERAHLDQYKRALHRHVEAGLGSRLKKRLSADIGNEMDQAQKEMAERMYNILPIHKRAAAASYIIPHQQPFEVLYRLNCDNLCADFTEDLSFRFSYGITALIQRFQGKNSHKIALKNPPQYTQIPPSISPAPSSMEVARTNGPSSLASHVGLSAEEWGLVSKFALGALTSQGTMGGLLLSGLLLKTVGWRVVAVTGALYAALYAYERLTWTARAQQRVFKQQYVAHASKKLRLIVDLTSANCSHQVQQELSTMFARLCRLIDEATTEMDTELSEVKEAIKMLDTASTSAKKLRNKANYLSHELELFDDAFLKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYT3</accession>
    <name>A0A835KYT3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000500">
        <property type="protein sequence ID" value="KAF9407157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYT3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="10">
        <location>
            <begin position="125"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9407157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="323" mass="37078" checksum="E224099E41107879" modified="2021-09-29" version="1">MANSLISKMGALRIVPVIFTQPSRNTTTKHYIPKFKKQRAQKYLKVELPDPNEDFGSLSSSKIRQKMKERGILPPRPWMERPFYLSATGGVFEPYVPPEGDGKASIVSATRAKQAVELLEKKSKSMMAIRKIKSFEEEFDQKEFVLQAQDTYIKAHESLANNDKKALRIYVTEKAYPEFRHNSHSKTIRWKFIESLEPPRVVHARCTDVISKENIFGQVTVRFHTRQQLAVYDRFGRLLHGSEILSKDVLEYIVFEKHLSNLYGTWRIHDKIIPDWTPPKEPSKLTRVMPEPEPEVVESTQTTESAVTTPELSEKPAAPAIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZP5</accession>
    <name>A0A835KZP5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000666">
        <property type="protein sequence ID" value="KAF9405886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZP5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="308" mass="35205" checksum="219563744DF42C52" modified="2021-09-29" version="1">MKTCASCNERFNDGVQCSSCKKYLDFSCASMTEVGWKKLGADRRAQWKCPACRVSSPTLLSPQPTASLDTVLSEIREMKHQLLDLPTLVNDLRSIKDELSDLKKCYDFSSGRLDEFDTRLINLESKVSEFEKVQDTVLSLQSELASAKLELMSHDQRSRLNNVEIKGVPLKKDENLFSIVEAIGRKIKYNCPKAQINYISRVPIHNSKEKLVIVSFLNRYVKEDFVAAARADKDLSTSDLGFQGASHRIYVNDHLSVESKKLLNKTKIIAKEKRYEFVWVKHGKIHVRKNVNCNTFIVRKEQDLNKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0L6</accession>
    <name>A0A835L0L6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TIMELESS-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000218">
        <property type="protein sequence ID" value="KAF9411648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0L6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="547" mass="61764" checksum="73F0C42B782D3748" modified="2021-09-29" version="1">MSLLEDIFLQDEADEAQELERVIEGDEYDERPRSRAVTPNSDDNEPKDDEAEEDKRRVDPTSTKAKRVTKNPRFILNPARLTGPRGIQVIPEHFKDFKFKGKGHEKEDLDLVLKKLEHWAYRLYPKFQFEDCLKKIETLGKKRPVMVHLHKIRTDQFLSEETVVQKDSSDEETQPPQEEDEFDKLLQQQIDLARATPALGSVKKAMATPATPLQDRSPFTMPKATSSPSISDEQKERMIRNRKLAEERRLARLKQNSMENTKQNNGPNISGIVEVDEEVENNVITKKSNRSNVIDSSDDECDVTNVKEAVAVDVHGSGRTEANKDAEADDLSKETGKNGNDIEMADVEADKEIIVINDGVREPSNVVRRNEHTDNVVEEINDDDINKNDATKDSDIIVINDAGKVSNKPITITDEIIEIKDHTETVKRVNDKREELIVLNDDENSTDITDGIEMTKDDNNVGDVIEINDAVTIENENITPVVEDSTNNESNIDIEDSSKSNESIKQNVQEDLPSKNTVQEVGGLDTNAKLTEAVLDDMMDVDFSEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0T9</accession>
    <name>A0A835L0T9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="10">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_012336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000441">
        <property type="protein sequence ID" value="KAF9407745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0T9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="746"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9407745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119830" checksum="D7C61276A19BC11A" modified="2021-09-29" version="1">MLKFIGIRGGCVVRCKDYAYATWSKAKAMKEKKKKAEEGSGGVAELNPWPEYIQKRITLWDKFKIQYEEELAKKPDVSIVVTLPDGKTVEAKAWKTTPYDVAKGISQGLADSTIIARVNNELWDLDRPLEGDCKLELLRWDNTDAQAVFWHSSAHMLGEAMERVYGGCLCYGPPIEEGFYYDMYYPEKGGRNETLRPLTGERLQRERQKWRHINWLIIDEISMVPYLTLRNIHIRLQQLKQDQGNFGGINVILFGDLMQLPPVSRITGGSYCFRQPSNLTGETNLWQLFSFCEWPQNMRQAGDNTFVDILNNIRVGELTMDQLEILDSRRIPLEGPFADGEAVRIFPTTKQVDAYNSAMTKKLGKSLKLYQINAVDISLEAKTYGKCPRKQYISDDPNKTGGILGTLTIGIGSRVMLRRNINVNHGLVNGAMGIIRRIEWPSLRREQLEPGELPQAVFVEFDDRSVKGNELGVGVRIEPSTVDFDALRGQGKIERRMLPLILCWAISSTDFHVLEGLVKKIAKEKQPFERLELTKEQLLEMFDYNPFKVRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKVKALKVTKEQELFFFHELSPGSCFFQPRGAHIYNTLVNFIREQYRYASAKHINKNDGVVVYAKSDIALLVEEPEFNSSASGLLLKIVYSIEDPNTAIDTFISLVSGAIAANTVVCRSSARKRILKPWITPGLLRCIRNKDILHRQSNQSPDNPTLSVTYKRIRGFQEVVSPNMFNAKLWQTSGHWAHYSENMFSFDVEKETFALKPMNCPGHCLMFDNRIRSWRELPLRLADFGVLHRNELSGALTGLTRLSCLDFLNHVYSTFGFTFQLKLSTRPEKYLGELATWDQAEKALEDSLNKFGRPWQLNPGDGAFYGPKIDITIQDAESGEKKRPVIIHRAILGSVERMIAILSESYAGKWPFWLSPRQVCVVPVGPSFDDYAVQVNEKLFAAGFMSEVDTDAGDTLNKKVRNAQLAQFNYILVVGDREKQSGTVNVRTRDNKVHGEMSVQGLIDHLNKLVKEKTLAEDSDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0Y5</accession>
    <name>A0A835L0Y5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_012182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000418">
        <property type="protein sequence ID" value="KAF9407969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0Y5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF14">
        <property type="entry name" value="FI16615P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="151"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9407969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="25586" checksum="17247658C4CAE687" modified="2021-09-29" version="1">MSSDEIPQKGQPPPYDNGAEPSRAGVTYQGGQPQVVVPVVVSHPMGPKPTPFTCPSCNQQIVTRVEHKSTTKTHLFAILLCIICCPCVCVPYCVDSCQNADHYCPNCSAYIGTKGQGMPPPYTDTPQPPPTAPLYPPLQPGGIELQQQHQQQPPTVIPVLVGTRPMGPKATTLTCPSCNAEITTRVQHMSSTKTHLFALGLCLLFWPCACLPYCIDSCQNADHYCPNCNAFLGSYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L170</accession>
    <name>A0A835L170_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000389">
        <property type="protein sequence ID" value="KAF9408350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L170"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033028330" description="MD-2-related lipid-recognition domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9408350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="17901" checksum="057BDDED5D49C14B" modified="2021-09-29" version="1">MLRVVAYVCALLALAHGQTTNVNQCTFHSGPLPIHTYIEGCVTPPCVFPQGQDAVVNIKFRAPRAVQSMTTHATAFLLIPIFYPLGEAAQTCNYLTNNSCPLKEGEEVQYSLNMFIEPAFPAGTSLPIEFRIVDDNNNNLVCIRVPIRIAPPVSSNMLAGPAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L189</accession>
    <name>A0A835L189_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000382">
        <property type="protein sequence ID" value="KAF9408448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L189"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="199" mass="22217" checksum="C7DF6DDFC5134FAC" modified="2021-09-29" version="1">MSRHPANGKDKIFLINRETVYQHYTIEHTCPTDNNITNDKSVRSETLVSRRMRKDALATMSRKTTPGEDVELSVVKVEAIKSKTRSGTSQEVSTKEKPDLRVTKALDKSRNYAYDNKAYIGSVNNVNDVRCHSSQEPPTGVYREQYWACSKWSWPTKAMAIGVGVLLGAGIVLLTALLLTMKKDGEDAFSQMFLASAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1B0</accession>
    <name>A0A835L1B0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1B0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9714" checksum="709A26679B120F8C" modified="2021-09-29" version="1">MAQRSLLVLSPILHAVYISMLWHIYLYEFPVAKVSVVKYARLRIKDHTHGKYDESQECSQSILDPTSDSQDEMNLEDVEDLMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1I6</accession>
    <name>A0A835L1I6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.13" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010001015">
        <property type="protein sequence ID" value="KAF9404326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1I6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048715">
        <property type="entry name" value="CggR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21715">
        <property type="entry name" value="CggR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="8">
        <location>
            <begin position="400"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9404326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="692" mass="76754" checksum="9CCEF3A37FB1A21D" modified="2021-09-29" version="1">MSLEMRVTEGGIEMVESKEHDTNHFWFEKKNGTDFPFYNDQPIKLSWKNWLIWSYLDIFRPTKERIMLDELKMIEAVAPDLLDIMQERFHILRNIYWMQPIGRRSLSDSMGMTERVLRTETDFLKNIQLIQTSKSGMTLTEKGLTVYQGLETVMNQLLGMHQIEKEISQYFGIKRCIVVAGNSDNQEKVLYEFGDILTDSLDLLLPEGNNIIAVMGGTTMALTAEHMGTLETEKRHNLFVPARGGIGEAMTAQANSVSAVMASKTGGHHRALYVPEQLSRETYNSLLQEPSIQEVLTLIEQSNCVVHSIGRALHMAARRKMSDDEMVMLKQNNAVAESFGYFFDEEGEVVYKIPRIGLQLKDVQKIPHVVAIAGGKTKAKAIRAYMKNAPKQTRKSLMTVKVGINGFGRIGRLAFRRIQDVAGIEVVAINDLTDAKMLAHLLKYDTTQGRFNGTVEVHEGSFNVNGKEVKVLANRFFTSKEKAELHLKAGAKRVVISAPGKETVISGASCTTNCLAPMAKALQDNFGVVEGLMTTIHAYTGDQMTLDGPHPGGDFRRARAAAENIVPNTTGAAKAIGLVIPELNGKLDGAAQRVPVATGSLTELVTVLDKNVTVEEVNEVMAKAANESYGYNTDEIVSSDIVGMTFGSLFDATQTKVMTVGDKQLVKTVAWYDNEMSYTAQLVRTLEYFANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1S2</accession>
    <name>A0A835L1S2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1S2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032941271" description="MICOS complex subunit" evidence="8">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="24968" checksum="E525A6C0D888F430" modified="2021-09-29" version="1">MLRKVVLGSVGVATLIPVVGAATPIKDAPPNPQKPPPMKPSELPIYEAPHADYAEKVKSKSDNEVGYVRSMLLAPVRVMREQIFTKSISGIFKYLREEENKQVRYGAVAMGGLTGFIFGLRGGIIRRVFYAGATTTAMGYVCFPEETKDIMKNNSVLAKQYVNIAYNFLYGVKPGDPQLEVNFPELSFPKDFSEFVDMTVSLASSVKQAVMPPPSKEELKPDEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L278</accession>
    <name>A0A835L278_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000223">
        <property type="protein sequence ID" value="KAF9411491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF74">
        <property type="entry name" value="DUF4456 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2202"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2268"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2496"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2562"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2213"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2225"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2287"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2312"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2345"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2597"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2633"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2661"/>
            <end position="2674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2693" mass="297717" checksum="0DD59E386AF11908" modified="2021-09-29" version="1">MDDHRYSFKGNKAALELDRFNRRLIKSVARLLLHEKKPESEVWKTLKRDTGCNCELLWWKLERHFIAEDRVDRVPRRARMNLTDWLMVDLVLVHQDLDFIGQDLNLNENFAPLEELFNLVNMFGIEGLKGEALAEAWSSATLYYNTNQVIMSLLHLIIIASFKRVVGSRRCHVRPRPQIPYPSSRIKDTNSKSSVSAAPRVSAYSKSSASAAPRVSANSKSSVSAAPRVSANSKSSASAAPRVSANSKSSASAAPRVSANSKSSASAAPRVSAYSKSSASAAPRVSANSKSSVSAAPRVSANSKSSASAAPRVSANSKSSASAAPRVSANSKSSASAAPRVSANSKSSVSAAPRVSAYSKSSVSAVPSVSANSKVSVSAVPKEPAYSNPTKSAVPKAPAHSKFSVSAVPKESACSKSSASTAPKKPIYSKPSESPVPEKSKFSKSIEPALISTSCSTPRSKENIIYEITSNSTKRYVPHVSLRTPLNNRSLTFLVDTGSAVSLIKSNAIKSMPVLQNEIIHLKGIDNTNETIPTSDIKRDNEAISYLMSHQIKRSALLGVIGTLSKKLFGTMDEEDAIRYDNAIHEIQTDTSKIASTLKENILVTTSTLKSYNNTLETIKTNEHELNVAIDALYEDIKNLTYISKELGIRSRILELTSMLENSLLALSFKVEDIMNSVMFGKSNILYPSILSPVELYTQLVDNYRFISDSRQLPVLLCLDNVHIILNISSISSYFSKDQIVFVLEIPLVKPQRFSLYHNLPCPVPYEANNPVSFTTIIPSSKYVAITKDRSTYCKLDELRGCKIINSNHYLCDVRISYSVAATPCCETEIISKVLTSIPEICKTKFFHGQVNIWQTLQNNKWLYVMSEKSKLNIECNNVKQTNEIDISGSGILYLPQGCVAYCKDTQLISQDNVNILLKPIKTNLNIINDSCCNRLSFNNMIPNLPPISLKNVNLDSVAYNPEIGHQCSPMLLQKRWYQMKAITRSKFYNFWYAYKGCIKRLHVAEPYKPTPLEHAIARRYKELITKPHLSWTELIEQRLVTLPDEFERKMIERAGSPMDIRRQSHDDASDLELVEPVVETIDLRQESDETLQGESNNDETLPRIVKVKQEPPDPDLEPQPQVEPKKSIYQEVLESTLKENQVIDAMLNSDGIDSDTSKLDNTDTVTNEVDVEPVTGDNQTRTVDVDDEIETVEEDVTKLDVAKEGNNVVEETKDVVEDDNVTDTVKIDSKTVTVQDRDGIVTIDEDDLTNADKRNDNNVTELVEENTQINKDDIVTEETPVADLVVPISKGDNIIDNESVHEENLVQNENKNVEDGEETGSISKPVIITDSEDENSDAIVEPMDTALDYSATEIAENTVPEDTGDFKTTNEDIDCKANVKVEALKYSFGEIPNEFSFVDDGIELVDDGIAFEDYDDQIDIKTEPEPEEPKIDPKLLMVPVVYITRLDDLKIFPDDDIENMSTDEDSNDSVVPENMRVKPTSYLLQKPRCRSYNPIQLCKNPDFNTRLKRLTVGFFKSHRNRALIKHCKPLTIDISKAFEKKLVKGTLYLKRSEISDVNITTEITDDSEIVQSATVVPSAMIAQSLIDNTKTADILPLIREAEAPPKPIEHERNTRINLPDISEIRRINQRLLIAEISPIQIQNRTFKAPVTLVSNSDPQSPAVSNPTPDVTEVQTVASNYTSCQVVNSLPEPSIRGRAGVLRGRGRGSFSWRSFVQQKPKPKSVKSYTTITWLSKSNDPNIISKQQECTLLTLDTLNKMLNLLGDKEGPSDTQKKSKFTVESTEKKLDKDLLQDGNKIETGVVCKPRINVKSAVNGPRQYKPRKKRVIVNVTNKTVPVNEERQKRKGLYCCWCRKRLLQMILDKKYVRGHDCPEGNCVCCCRKLLSSYILQDEKIKAAQQNADKNMATIQCAEAASACANITKDIPKDAQNQAGPAVTKVSATDIIMPSVSTVTVDSGGQFDIHLPKESSTLGSEVTVAASSKEPATTPFVENVSVAKNPTFAVPLVNTLVSPMIEAQPVLQPITDVNLKKFGVLKTFINSSGKKPNRSTLTKSNKPFKPPKFLKEKLIFLNSKHISDKPAKSPIYLGKNKVLMTTIKFPWNLKLFEETKKALAPTLKLPAGVSLVCLPDGTISYSIDNNHVKALDLALMPSIIATVQMHMNNALQQHRLQFQQNVQPTVNSNNAEEASREEMPIATAEQLVQTDVSPSREVSIEKESKHPDPSFTSGCQLQPLSIDDANSKKSELKLPEDQIKPSHANLPESIEATLESEQSVGNEDKAEQEVLVAQAPSSSSQADSVTDTQEMPKVPGQPNQTEANASQESKPPEVQSQPDQLIEKPPSENIADSDQNTQQPKKTKNILSDLMEMSGIFDDDVTPPPPVTLPTPAQQVQASQSLLSQLGASPQPVGTSKLQGTLLGPIPNLISCQPLIKTPLGDLSPVTSLYELKYACANKGIFFKLDCDTGYLVPINVCLKAPVKQQKVKVIAERTVIDLTEEGKSNQSEPNLSPEKGLVSDTEGSNSHVKPVSLLKVAVPSILRRLNTNNKSKEKINKGIKAAGDKVIKKKRKQQLQQYDLSDDNEDNIAQSSSKKATKRSKGADTQELSADKLQQDEVTTLYDSSDDEPLSKVAKLKRQEEEESLSKEKQMTKIVAGMPTTEQDEKLDDNLDTEENISESDQSHSSDDDRENCILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2S1</accession>
    <name>A0A835L2S1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2S1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="994" mass="113880" checksum="F2F77A0F0731FAC5" modified="2021-09-29" version="1">MEKTRVLSGAALVAKGITKIEASLPEIGLKDVAPNGSWLEQKQIQAALEAWKYLIEVERIEKCGVLSHAIWRDDLKLAEVTQKSGGHWQYLGHNVGKMLFLNPEETLFLMETNCLQLKHNEVTVSLQKAYALLLDSSNRIQYQVYASLSRVGYKVFRHAGPKWNVETKSHSQEVHNVKEVDHVDTTVSSQLEDSQSTNDSTSEDNTKSDNNESSLKTVDDNVKNVDSIETNKAIDAENKDTSKSEQISSKVGTDNEALDSKDVESTDDQRNSAEVFAIEISKSVDSQESTEKCNAISETCVEKESPDKLHVGEKEIKTSNESTEANEGMSPPKDDNVHRMDVSTENVTTADSGTVKSEGDLDEKVSMNTGQSDSNIDVETKKFQHNYEKSAYSYVSKIDKMSKRQMKPSDSRNIQTYFENIPDLSKQRVFAINVPDQQFIPKNVFVNKENYVLDMQNIKARSRRSASSETASYSSSDEVNGRNIRRIRSSSGTELSRNQQCIPNMRLPRYQFRPYGFWRPQNSINFYQLMFFQTRFQYNQRPPPFSRSYEFSPNASDARKRLRICNIAHFQAIRNAAVRLKQSLISGVTDMRKLEELHNILHSYNTRYKTRLRLSENFDVINEEKIIETIELDDDEESRSKRPRLEDGDDKFDENLYRLKQLALRLRELESKDKATASHRRAFSKAIKTFNQSYKADIYFDTKNYEVIDRKCITLDSSSESDCVVEEAPAPKRKKLRNPFNILKRRSEKLSALNGPSTSQAVVSEVSKAESNEGENKKVDNNKYSDHLLKTFKEEWLPKEDDFGRAEIVSKLDMNMRLLVNSKEQYLQEFMKDQLQQYSNWLEAKISFFKYLEETNNQMNSERERLLADTDVNTGLKPLIDFEDSSDMSKALEKLRIIRNNQGTDNQTSLKIDFDVYNRDVQNYRKRKPPKPHFRIVCIDESAGVPSASHVMALHSKYNDEVPIVFAVVGLGSVSYIQLNPIDLPIYIPNNDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L381</accession>
    <name>A0A835L381_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L381"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="181"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="382" mass="43469" checksum="1401690E54A4B46D" modified="2021-09-29" version="1">MELSAEGKTPEYMTLAGIKFKLSLPHLKDDPQLKEQLLQGIKNGHMAPYYKEVCTDLGWKFDQKLYDDMAKENQDRLSKFQEDDSETPVWQDRLDYLCSIGDKEGATALAVSKYEDSTLTTNRRLDAVFALFRIAYFHGCNVKEMGKNINKAHELVDKGGDWRSRNKLKAYEAIYCLAVRDYSKAADLFIDCVSTFESYELVDFGTIIQYCVLACALALERHALQSALRRQGAAVQALRSRFPELRELVESLHECRYADFLKSLAWVETQICVDPVFRPHYQHYVREARIKAYVQLLRAYRSLSLDNIADTFGVSREFVEEEISNFTAAGRLQCRIDAVAGCVVTGAGRGADADRSQLYQATIREGDLLLNRVKKLASVINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3K7</accession>
    <name>A0A835L3K7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_005600</name>
        <name evidence="3" type="ORF">HW555_009346</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9411991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000057">
        <property type="protein sequence ID" value="KAH9645055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3K7"/>
    <dbReference type="OrthoDB" id="9974725at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000318">
        <property type="entry name" value="GG16823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9645055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="184" mass="21350" checksum="CD93372FB760DD0C" modified="2021-09-29" version="1">MSISEFRRKKLLYVFNVFFDVNQSGTIERKDFELAIDKICHLRGWKPGDPKNTETHEIMIKIWDGLRKRADSNKDGQVSVEEWTSMWNDYAQNPSAALKWQQLYAQFMFQLEDASADGTIDSDEFTTVCSSYGIDPQECKVAFTKMAKGKSSVSWEEFQELWKEYFSTEDPNAPGNFIFGRTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3U7</accession>
    <name>A0A835L3U7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000420">
        <property type="protein sequence ID" value="KAF9407952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3U7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF71">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="628" mass="70892" checksum="52369A11A0A81A70" modified="2021-09-29" version="1">MQLSDDWLLGLTLAELSQTQGVTAVDLVLSGLKEQDWSDNDTPCIEQTLQILNNVKNYTVWAVWVWNSMHSPVGSFYGSEYSLGNYDQCLNAPTTTADPKIVTQYCLAYITLTEKVYEKREHNVLGSTEPYVATRTPIGRNLNKVIWGTCLPSTCKPDTISKILKAMYQINPLTPSVPRITVDTCEAADKTTEYSFGFYAFMTLMTLLVATLAISTYYTERSYTKTSLHTIACAFSLKRNWQTLTRKTNDDIGVLNLLKVMLETRNPLLNTVKHIDLPVDNFLMLSGLFLVQGLMAKNKKPLISLVSRYFRLTASYSVVIFYVISVSVYTGAGPFWQKFAGREQQACARNWWLNLLMLNNYFNADNICLIVSWYIPCDYQLAVMGTILYLLYQKKIMGKAATGLTVVLAVLTPGVVTYWKKLPGILLYHDVESMIDVRKNDVYVDTYIRSHNRAGPYFVGMAMGYILTTYKPRHYRNVISKKISLVLFVVAFLIAYAVATHPLSYSNLQYNHLSSALYAAYSRNLWAIATCITIGVIEYGNVASLRSFASWHGFAVLSRLAYGVYLTHSIILQQNLYSRKNVQQFDLVYSEGLHGLGVLAMSMVFSLLLWLFVEAPLNNIVNIFISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4T2</accession>
    <name>A0A835L4T2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 50A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_012621</name>
        <name evidence="8" type="ORF">HW555_008046</name>
        <name evidence="7" type="ORF">HW555_012119</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000409">
        <property type="protein sequence ID" value="KAF9408078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000149">
        <property type="protein sequence ID" value="KAF9413843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000688">
        <property type="protein sequence ID" value="KAH9632796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4T2"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9632796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17049" checksum="F063D28C4B358521" modified="2021-09-29" version="1">MSCFENLTMPSCVWFESGEKRNIVASIISGLLFFTGWWFIIDAASVYPGNLPNASHVCGVMATLSLIMVNSVSNAQVRGETYTGGCMGPRGARLWLFLGFVVGFASLIAACWILFANYVNAGSSKSAWPGVSLFMQNAFIFAGSLVFKFGRTEDLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L513</accession>
    <name>A0A835L513_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_004909</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L513"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="507"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9418203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1148" mass="128888" checksum="EA982833277AD4D2" modified="2021-09-29" version="1">MIMVKYPTSNISKIYLQKLHRKIHISKYRLSKKVASATSLTSPALWEVQPLRAIVGGGCPLGVTAKRIQSLATKRPAEDEIWRKPKKVNINARRPLQRPVSTSNRFKDLPDNPDDGQGESSQSQHTSRRAKSIRVPPIVLQIDEEWTHKTITDTVRRFTKEFHLQYRSAGKVAIHCYSNQGHKTLVDGLRAEKLLFHTHSRKEERKHKVVIRGLPAEAVDSVGEELAALGFSEAVVTILKRMSSSTNASTCPPILVQLLPEQKSANLNKLSTCRLDNIQAKHQAQKVAANIAIPTQKSTPASLTIPVPKESKPPVQMQPRPLLTDRTWANVVSAPKDSRRTAYISEFEATTGSDEVTIEMLQILNIIKRIKTQFISCPTMMDKVILVLTHLDIIAVNETRINEKVPLHIPGYSCYRQDKRHDGRGQGVAILIRSNIPHSQVCVPVLGHLEAGPEMVRVSKFYKEAKNGRYLRYLHEDTRTLYETFRRGVKESNNGNCLGWREGPNKPYVWQTYNETLLRAKNFGSGLICQGLVPGQNTFVGIYSQNCPEWVMTEQAAYCYSMVIVPLYDTLGANACAFIVNQSEYKRFDSDSYSPSFSESRAEMSVVICEDDKKANLLLDQSPRCLRKLITIKEVSPSTHQRARSRGVEILKFSDVEIQGAQKDHPCLPPKPESLCTICYTSGTTGMPKGVMLTHENVVASMCSVIMQLGEHRPMKHDVMISFLPLAHMLERCCENALYMVGGAVGFYSGDIRRLGDDLIALKPTMMPAVPRLLNRLYDKAQSEISSSKIKKLLFNMALSAKESELKRSAIIATAIVVIKLRTRTKGFIDIKIGTLISLVITLAFIRWFYSEGRGIVRSDSVWDKLVFRKVREGMGGRLRIMVVGSAPLAGNVLTFARCALGCLIVEGYGQTECTAPVTLTVQGDHVPEHVGPPVACCKVKLVDVPEMEYYASQGQGEVCVQGANVFKGYFKEPDKTREVIDHDGWHHTGDVGKWLPNGTLKIIDRRKHIFKLSQGEYIVPEKIENIYIRSQYVEQVFVHGESLKSCVVAVVVPDVDVVKCWALENGIKGTFSALCEDERVKKIILDDMLQWGRNAGLKTFEQVKDIYLHPDPFSVQNGLLTPTMKAKRPEIRSYFKPQIEDMYKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5H4</accession>
    <name>A0A835L5H4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5H4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="19844" checksum="7292D1D288F0B466" modified="2021-09-29" version="1">MDALLAYQKEVLDNLKKSEKNYKKTPKDRLKKPYLETRLDNLEQLWITFKDGHRSLIGKVTLKDKQDTYFTEDMYEVFEELYVSYKTSLKEALQPYLASSSGTSSVTPKISAEKTVIIKCRNSASCKRCGRRHHSLLHFEKEVSSESTSEDVLVQSESDKSCEAHGFSSSGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5J9</accession>
    <name>A0A835L5J9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_010506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5J9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016250">
        <property type="term" value="F:N-sulfoglucosamine sulfohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032946122" description="Sulfatase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9410380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="549" mass="61507" checksum="553EA289324A6A48" modified="2021-09-29" version="1">MAYKTSTVYNLIICFFITDTVLSDKAATSGNVLILLADDGGFELGAYMNKICQTPNIDALAKRGVVFNNAFTSVSSCSPSRAALLTGTPSHQNGMYGLHRTVHHFNSFDTVTSLPNLLSAHNVTTGIIGKKDVGPAAQYKFDYEQTEENNRVNQVGRNITHIKLLTREFLAKANRDQKPFLLYISFHDPHRCGHTDPQFGPFCERFGSGEEGMGLIPDWHPIYYQWEQVQLPYFIQDTEAARRDIAAQYTTISRLDQGVGLVLQELQSAGHADDTLVIYSSDNGIPFPSGRTNMYDPGLREPLIISSPRPRSRKNEASFAMVSLLDVMPTVLDWFGIPFPQETNDISQTDTAKSLLPILEKEPPYSEDDAVFASQTHHEVTMYYPMRAVRTRRYKLIHNLNFGMPFPIDQDLYDLLNRTASKQPLPWYKTLEQYYYRPQWELYDIRADPAETRNLHGKYMGRTSDKLAPCRRANRVVARRQAGAGARGGGAARALAALAARVGRPLAVRARRRAGARARRRARLPSAAASLAHSAPTRAFILLVLRSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5V1</accession>
    <name>A0A835L5V1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000111">
        <property type="protein sequence ID" value="KAF9415414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28058" checksum="F131A9A000B04EA7" modified="2021-09-29" version="1">MFRYLNMDHLKNKVVVITGAAHGIGAQIAEDLVKIGMTVIGFEPTEDKVEEMLNKMNSWGSFDGQLIPCKCDVSKEEDLKNAFEGVVAAYGGTDVLINNAAIGKEGLISTGIIKDLIDVVDTNIYGLITCTRYAINSMVKKDVLGHIININSICGHYMPPFAEPKINMYIASKRTMTVLNTLLKNEFQLLNRKIKVSSISPGIVRTGIFKTAGISFLDEEFFEKNPHLTVKDVSNVVILVLTAPRGIQSGVATNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L631</accession>
    <name>A0A835L631_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L631"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="28985" checksum="F19951313E0DA356" modified="2021-09-29" version="1">MGVGVCVQSYRRKAGRVHSVLYLLCDQMSMSYIRNVLSFIILDPSVDQVPVCSFADSPSLNYSSKGISSSEMKFLSGLTLAKLLYFGSAMKLNPVSEHSLILMQSLWSSVIVYPVMMKGTFCLRMASIVEGQGSLPLWNKVLAVLIVSVRRVQVIIDEDDSQLLQLRSEVEEEHLPLVEGISLKLELSSNHVDCEDVPYKVEILNQLTNLLFIHRSQYFINLLWYLLRFPQHFGRHLRLQSTLGLLEAHQLLIEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L639</accession>
    <name>A0A835L639_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000052">
        <property type="protein sequence ID" value="KAF9418642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L639"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="159"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="580" mass="65974" checksum="906FE459C3C1F0D4" modified="2021-09-29" version="1">MAEMLIAHRIVISKNLSRRVNLFSKQNGVPQNLKLTRSHKILALVPEKNACSEGSSSSDEETNVYIPPSPDTSDPPSLASSLEGLNLLDSSTESNKEQIDISVDAPLTPIFNEVFPSPTTSNYNILPTLNSIQSLPTPTVEQSSPQPGTSRQQLPLTRSKHRYFKIRPVMERIRQNFLKVEEEGKYSIDEMMIPYKGRKAGKRKQYVKMKPKKWGFKNFVRAGVSGIIYDFLLYGGDDTFRGLTFRDKEASIGLGGKVVIALCQTIRQKPAIIYADNFFMSLELTHILREEYGILSLGTIRTNRLRGCQELLPTDQQMKKKKRGSSAQVVCNKNKLAVVKWNDNKVVTLISSYIDSHPIETIKRYDKDEKKKVHVECPQIVKHYNKHMGGVDLADMLISLYRTPFKSHRWYLGIFSQLIDMCINNAWLLHKRDGKNIMLKDFRFQLFEGLTKSNKIVKGINATEDIGEDLKIHKPVSVRPTDSVRFDDKGHLPEAGDETMRCKYCKSDTWGYHVSCHITTHDFTLYASTYKGGFAMDLLGGLRSFAVERVFLWGECKNHPAIDLCAVRRRGWRMTVSITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6W1</accession>
    <name>A0A835L6W1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2038" mass="228471" checksum="48C3025923D16376" modified="2021-09-29" version="1">MSDSVSVDYAIVLIWLAICSVYTTLLAITALGVVFFLRKRRSSILKSQRPARTPFSELEFNVATPTDTAKSRRVSFSRRTGVAEFVTNEATTTWKNFYEEHNKSLESSSNDSEANASRQPVGHLGKRIFDQQFEEVEAVDFIGNINPSLIANGSLNNVNFSQQLASLDCTSDAKLTAPQNKFELSTFTEQQSKIFGNDFIASSVGENSGRIDVNFSNIQEIGGKDDLDEIERDLERGPGNMGCHGPFSSRQSLSEYIEVDLNMTHVARNDEDMSITDTIHSPVQDVSKSTSIDKKVSLNPDWVADKENIAVNPYVTPCEADNFAVNEEPNQVLVFDGKRLTLQPDKPDIPEPEKNYRQTLLPSTSFETPQRKTIVLNVNDDLPNFVDDMLNSKFENSAFVSKDGGSTSLAVDITKKALDTTGNISMTQALPTNIITETAVTSENPSKRRTIVFNESMGNISVTQSLPAKLLCNSDSSERRRTVVYENDTGNISITQAVPTNILVGETTDKEKRKTIVFEDDQANISVTQALPSNVILDNKVKEKRKTIVFEDDAGDVSITQAVPANIMLPEKPAQERRRTIIYEDDVGNISVTQALPTNLILEQANSVPERRRTVVYGNETGNISITQALQSNVILERVQITDQFNFLNRSTRSPPKENDTRRRTIVYENDTANISITQAIPAPIIAESSEENCKSSGDDMSFTKIPENPKRTTIVFEKEDNDVSMTEAISTNLIDEAVNKRNTIVFNNDDADVSMTQALPTNVFLLDKLDSAVEQTVDLPEPVEEKDENVINYETYEEMPMAKEETLLENRKTVHFPDDDSSQIPITEATSKVEMQEEEVKKTVIYDNDVSCNMSMTKPIPAELVHIEDEMMDKSKCPEIPEFGNLTNRLTDVVVYQTSTTYSAPPTITEQGDLKSKSLSSTTDSKLTTSDNKDYPELPLEELGSEDVSLLHPRVDERSDQFDLKPDSSAMDVDEKSIEATESKTTSVEAKEPVKIESRNSVLDALLDMSNTDVSGSEDKDFMTQFDSVQSVSEKKEEKNSNISSESMFYITKDSEDDTQTDKDENSHNSVPPLKETPQISTEYKEDDEEIHVLEKKIEELKTSVTEVKDSTINDFYERVVKSDQEAVREEEKIKIREQSEIFKKANDTKELLDMISDFTEKDEEEYEPVVIKVKTQPAEEEKVEVVEPKRMSFAPKRQSIVLSREDLLNNISMAQAALQKSRLALDDSECADDTKDSSTDSSKKSDHTSNEVVKTLNFDDESMSENDFKSDSKYSPLKKTAFGETSYMMESKAKVIPTYLKDVSDGIKELMLDLVKPMADNIPFDGGADKTVRKNPSTQSMQIQANLITSSQVDIDSEMESCLESNYESDKMSSLAGHTLNKSRSRSFKSPIKFTSNSSEKSSEFEVQSPRQTHMYSRMAVEHPVSPKVLVFDHLNPLNNILLSTMDYAEAHKYNPNKSNDTLCESDPSRTALIHFKDDPKTEPEFNHVMMQYCVDSRPHAIQEEDGRDQKSMHSSMSRATSKDQSIEAQMLQVKDNEANTLIAMKGNKELLEANSDLTLVDDALTPRHRGDINSHSTSHTHNDLAACRKSKSPVKTDEEEAENEKSATEELMEHSNLCTKAKKRIYSPNDKEKYKNTQSVLEVTPKPITKIKKISISPKINKVQINEDFKLMAAEKDTTEPLTEKQANKSKIIEKRSPKKEKASPGNITVQQLITEYRTVDSGIDKQLLDALKPKSECSKAPSQSDVMDSNSLDIVSSFTSSKNLNAAMDIHSSSTTHSQFSQDMQMPGKMEYNPDIISSVSSNLSETDSGVNVVAKIDMLPFMGSHECEWESSSADTWSFRLLHGRLRLTARLAHRLDNSARTRVRGDTPVLDINVETVQQDKKNPVATLCVRFACETMRYMVSRACRGPSCVASDIPPLLRRCAAVARVALRWGRAMHDAKLHLAYTLDNDGYLTLKVSMRVELVAEDARTAPWPLACNVRVARVVSDVSVHEHEVRRVLANTPRDWGHAPRTIWRIFRYLKHKTRDDDLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7M0</accession>
    <name>A0A835L7M0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031907">
        <property type="entry name" value="MCM3AP_GANP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16769">
        <property type="entry name" value="MCM3AP_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="359"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="962"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1663"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1699" mass="195621" checksum="E9C614085F54C109" modified="2021-09-29" version="1">MKRCTNVPDSLLEGAAAKKHFSKFGRVQKIRLVPKRHMCIIEYDQPSSIEKAVLNAGAYDGFMFDVTRSKAKMRRRSSTKIEDDPDWVPDSDVEEELSAMGATPTYRVTRQKSMDVEPEPKPKMRITAKPLKQMPIKKTIPIRAKKPVVTQPVSVVEPPVAVVTTQTTMTTAEAATELFQLRSKISTTPDDKWRILDARDRILRAWGGAGSRIKVGGATIGTCQDMCPEKELLQRQSEHQVMTLETVLDSDGELEPWRAVKQYSRSSADQEIPMCYELRPAGVLMRTCAYLLHEIADTKRQVSLADWFHFMWDRLRGIRKDITQQALCCAESICLVEMCARFHAHCAARLADLEHTQFDQKLNTDNLTKCLQTLKHMYADVGPEQKPREAEFRGYVALLNLGDANFWWEIKQLPIEIQKSKPIIFAIKVFNAIDNNNYVRFFRLVKEEANYLQACILLRYFNDVRARALARIVKAYAPRGGSRYPAEDMMNSLAFETIENLKSFINHYGLRFARTEDSDGEVTIILDRNQFIEDSDPYPISRAINLIESKRKLSVGEIIAGGQLPDAGYSRHTLYTSFSSDGRLKESALTADDQGYNTLNDSNKDIQSLKAEIQKLCQGKAIVMDKPPENKINVFAKPDIISTSPKQVPKFSAPANPIFMKPPPSTENKPFLFKPAIPVASSDIIKNSAEKIFSEDTKSIFSFSKPQETPVTNLFTGKETVKRLFEATSVPETNNIFGKINKVPNAQPVFRGKIDDKNLFKKPEENSVFQPQTQVKPSGLFTGTASKNLFAPNEDKSGQKQSLFTNKSIFATKPDAGGFEKGGNIFNKPVPPSASEEKPSSIFGGFGKQTNVFAKPSNSEDQTKPNSIFTNGEATAGKLSPTSVFKSAILPPNGTDTKNYSIFPSKNKAQTVADNILNSITNEAHSIYDFNQNEDEEQKQAELQRLNAERIRKEEERHLQEKIRQEEEMRKQELQRQEEERRKEEARKRQEEARKRQEELRLQEEQRRKEELRKQEELKRKLEEERRAELKRKAEEEKLFKERVEKESIELVEELIDEVNNPTVTSILSEELDKFDSLMRFANTVSDEILLNMSTEICESELKAEIFLTKRIMRKWFYVWRKHYARNIKRRSLLEDTPVWLPQHTPLEEASYLKRLVQNAALSNMNAIHRGYKFAGELRQLPTPEKYNIMEIIRSPLLKRMKQISYPYDKCFFWKVAVVSPGANKWLHRKINIEKWLFDVFSDQKQHEVSNTLMHVSKQSWNHLMDFAISVSLTGRDKGIDGTEAMEGANALLFYATEFDNDLIETINVTLNHKYPYQVVPVAVIIPKLDHVQLQLDTNLSNLVRNNVISAYKIFVIDSQNVFDSLNVSCKSAMKWLAKKYPKIPPLEIDHLKSICQRYLGNEIWCRLRLEKDTRMSTVIKDLYKLVKCYNAAVDNLTSVITNEDLFNYSSFPLEFQPYLDTTSPYPKPYEFIPSSAKTSDNISAIKRIMNQLKLPDPSLNFRPLNAISMQEQMNSYCNQIGWFENPEEVVCRVVAVLPKELSDISMPCEDFNKYFAHYNLIDFMNIIVYEKINRLNNFENRFAIYEKPALENYRSALWIYEISAISEMKHKAIEYEDDIDFYIEAKRRKIELDSLDYLMLEDKDRTLVDESLKEKDKDITKYNNCAEAVEQLERQIEEEKKKSLEFENYLRAALGEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7N1</accession>
    <name>A0A835L7N1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7N1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="351" mass="38987" checksum="91F1CBD145CDF76D" modified="2021-09-29" version="1">MTTLILSSNNMFEWLNAHDLYLYYEHKTALCSACDNRYELDCDGYPEATYKLKDPEGKKNWRCRACIRNKRYNNGDVIEASNVTLRKKLTIKPSSPTELLHSTKVQRCLAPKPNSAPNSTSLFDSQVLNDCETSDESYTTPNKLSRSMDGTISDLISISDMKETINQLTNKLQSTENEMENISLENQDLHKQINKLTIEITTLKSLCHSSLYESPVTNNKKIKHVPSKQNMCSTPSSPVSSRRSTKSNDNEIVLGLKQKILSLEQQLEAAQKEIIALTERIYLITTTPVPPPPGTTLVTPPPPGTTLVTPPPGNTPVLIYIGLVTESSEGIPDSIAQDWVETSVHTGSGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7S9</accession>
    <name>A0A835L7S9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7S9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="10834" checksum="D3BC0D1EC8E1D7C1" modified="2021-09-29" version="1">MVKSAFWKYNLFSPETKPLTDEITKNCLDDKYFDYVTSETYCDYNKFELCANVNALMGCQEFYSTPSCEALAENVAICKPVLQDYLDYLNGSGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z3</accession>
    <name>A0A835L7Z3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055035">
        <property type="entry name" value="THAP9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22824">
        <property type="entry name" value="THAP9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="740" mass="83874" checksum="8DBE7C0A06C9183D" modified="2021-09-29" version="1">MRRDDWTPSKFSRLCSLHFEPCCYREGLDKKILHSYAVPTIFTNQPTIKEKIPVKRRIIMKTASTASTSAVDEFKENIKPIKRKVVEEECYPITSSAVASTSTTPFISLCADTSEVARLQYTTERLPGTRDVNSLKKQLAHYKTLAERRGRKLKNLQRKQQRTAKKIVNLETIIKDLKSKLEGEQLIMLQSSMSLDNKILSRYIMKSQGYSLSKEYPIEIKKFALTLQFLSPKAYEHVRNSFNTVLPHPKTLSRWYKSVDCQPGFTTESLETIKVRCKLAKKKLYASLSIDEMAIRKHVQWDGTKCHGYVDFGAAIDSPSDDSPLATEVLVFMVTCINEAWKIPVGYFLINGLSGSQKANLVTQSIRLLSDTGITVISLTFDGAPANASMAAHLGCNLTENEIVSNFRVGENEVAILYDPCHNIKLVRNALGEKKSFLDKDNKEISWVYLEKLQEVQSINSLHAANKISAAHIDYHTQKMKVKLATQLLSNSVADALISCRNLNIEGFSDCEPTVKFIKHFNDLFDILNSRNLASHGYKKPLLANNITEIRNRLLEIDAYIDGLRLLDGTPLIKSRKKTGFLGPDLSEFSEMVIVYIAGYVVRKLKKIILCEQCCKIFDNTASENHISANLIFTKNKGGLHIPSEDIITICKYSEKLFRHYLHILGLAELKYLVQILHFYFLPAHHGYGTIRRGENSRDLMPRRPTNRTIQKKRTDHASGDCTGPLIMYLQQSAEAESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L865</accession>
    <name>A0A835L865_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L865"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="27229" checksum="6FF950B752E91918" modified="2021-09-29" version="1">MSNNLQDDRIAAALLEENDTSSDDENFLPSSDDEADHISEASEVRSDTDVEDAENNLEPYLDGTSQPFYLGKDGRTNWSNKTCLPPQFKTRREEKSSVFGFQKDITIVSYIPKPRKCVHMMSSLHHDDEVDPESGDQRKPSIITFYNSTKSGVDVVDKLARTYDVTRNCKRWPLTVFFSMLNHAGINAFIVYILNNSIERKKTNLRKNFIKQLGLSLLEDHIRKRKDNTTKYKKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8I5</accession>
    <name>A0A835L8I5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8I5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032897937" evidence="1">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="425" mass="47990" checksum="7AB37BC7CA90AF97" modified="2021-09-29" version="1">MASCITFAILIALKFAAVFSDDDEDKLPGDGTQEEEWHMDFMPTGYLPDSVYRELAWYGILQIQPLHHSSKYKVAAQLIWQHTLGRPHVIMENPPQSTQSPGKVSRQILAEEAAKWSREQRAVQEVFMENIKTGGNGITVRTVVSSTKKSVYIIQNGRYYQCPPNSEPDLDDYRKQPNLHDRRCTFGQNSEEVPLDPCIEAEVAPIEYSFNEGWMFCLGNGDRENNYFQNGTLDCGNKTKIAVSKFLDECAIDNNIVITFEYFGDEPRKDVLRNATLCTTWDPCRLSYLYRLEPPPVGLMPAFPTTTSNPCESTVCPECLEENADDLGVEIPLPRQWKRGLNHHSLRPLPRILRAAGRQRQRRGSGADIADPFSKLAGGSRVIKEKLMVALSPSPKTDTGMKNMQENKMIKIKIILSTVDDLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8U4</accession>
    <name>A0A835L8U4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8U4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46954">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46954:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="416" mass="47687" checksum="4CEDF550D31AE80B" modified="2021-09-29" version="1">MFKKEFNELWANAKQKYSTKEEFVKWANDLLADYRRKHQAKKSSNILYYCSNSKKNASEKISVLPMTSNEPNLPVKLPTPAICVSPIGTEITDEGNVTTKSTSTGARKRKGEDLDCSDENSPDTPSASSSILQPVRATPAQDKLKNQISLLQMEFDLAVRRRDFLGATENETRDVTKLRREIDKCTKELRKKEQHMHLPSLQWYSEHVRESQYLLQVVKCDDRACCGDLRSSLRSILPARFVIPPYPILQSSSGLCIPKPQEHDGKTFATFLLRRSLGITPTHEGFNKLPYDLYCPSLQKDRRQLMERTCQWCGLYFCTKKKVKEHVNSCHKQPNPSSNSVEMHNVRPSRILTRRSIGRSKEILCVVRENDDTEWLDETDVDFQQSTVPTTDLQDAYPVVSVEECLANPWSEDNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L908</accession>
    <name>A0A835L908_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L908"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="25818" checksum="D381CF8CA54932E7" modified="2021-09-29" version="1">MALGTIYPYGPYENDLRARGPVICNFSHETPELVVLQFIVLMTPIVLISGMSLDEGRQSQRPYRYGMVLLCAGALINWLGLAEDYAEPVRYVGVACIVAGALLICAAMCCWLQSPARQPQTDRASPDTHQIDDPIHVISMPDEETMQQKPPDYDTVAGAPPTYDDAIKLNPARLLPATSSARHDLPPTPHLTDVAIIPGQPDDSVPPTSPMTAIAPIHRSQVPKTPPPPYNPTHAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L935</accession>
    <name>A0A835L935_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_007231</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L935"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="938"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="254"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9414964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123719" checksum="C7CDE654D91CDD8A" modified="2021-09-29" version="1">MLNLRPDEYEVIGETQWQIIESSGDEQTINIHGFKYSKLRATLLHTVCILLCGLPYFALAYYPSYNRFKYVKCSLKTAKEICVIDSDGGWTTEKVLEVDLNLSNHKDNRLRYFMFKHNRFIWLNDQGVFINVLALNEKLTIQLLMENMSGINKRQQNELIKLYGTNSVEVEVKSYWTLFVEEVFNPFYLFQVFSIILWSLDEYYQYATCVFLLSVATCMLALYQTKQMSINLHKMAGSTSAFTVTVLRPTRMGREECVVNASRLVPGDVLVLPPDGCVMPCDAMLLTGTCIVDESMLTGESVPVMKGPPCSSPEIYSTEGHKRHTLFAGTHVMQTRFYGNNQVLAKVVRTGFYTAKGELLKSILFPKPFGFQFYKDAVKFVIFMFCIAAIGMGYSIWLYVVRGSLIGTIVLRTLDIITIVVPPALPAAMTAGIVYSQNRLRKNRIFCVSPPRIVICGKLQVMCFDKTGTLTEDGLDFHSVIPLRSGEKFGECVVEVSSLPVTSPLIQALAFFIQGQLKGDPLDLKMFEFTQWILEEPGPENTRYDNLTPVIVKPATSANGSMQNLDDFDPFTMEIPYEIGLLRRFHFSSAQQSMGVITNVLGQPQMVYFVKGAPEKVAGMCNPETLPENFSSVLNEYTSNGFRVIGLAHKKLDRKMKWVDAQRVKRSNLECDMAFLGFLVMQNSLKPETTQVIRELHEASMRLIMVTGDNIMTAMSVARGCLMVQPHQKLVLITTGQPQTNDSRPPLCMEVVGEGAPPKLALDAYVLALEGKTWAVIRTHYPELMPVVLARGMVFGRFGPDQKTQLITALQGEDVVVGMCGDGANDCGALKAAHVGISLSEADASVAAPFTSQEQNIKCVKLLALEGRCALSTSFAIFKYMALYSLIQFFSILILYNFYSILGNNQFLYIDLVLTTLLALSLGRASPGPVLTRQSPPVSLVALSSILPLVIQVSLVLLMQIASIYLLYAQPWFKPVEGGPDVEQVLCWENTVLFIVTAFQYLIMACVYAKGWPFRQPFCTNYYMMITLVTQSVFVTVLLLCPWQWLADFMEVEAMSTADSEQTNASLSDCEKFSRLARVMRRRCDKTAEGEAARPLCVPSHLQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L947</accession>
    <name>A0A835L947_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L947"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000078">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="209" mass="24055" checksum="C990A6A6D905FE9F" modified="2021-09-29" version="1">MATLIQSYEQQYSILTADITAKIGRLKSGSEDNRDQLTREIQANFEEANDLLEQLELESRGIGAGSRVAAYRAELQRVRDEYRSVLNTGSYNYENDEVFDDWSGANEQHRKLLDNTERLERTGKTLTEGYRVVLETEQIGAAVLQDLSVQRETIQRSRGRLRETDEQLNRSSRLMNTMVMRALQDRFILIMVFLVLGVLLCVGVYFYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9P1</accession>
    <name>A0A835L9P1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_003027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9P1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF1">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="4">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="594" mass="64984" checksum="C239D89E13515055" modified="2021-09-29" version="1">MLCPLSWIVARGRACPVIDHYTSRKFTRAWEVEAAARAQAYIVQADNRASSYLGARCKAKSDCGVPNSHCERGVCACQPYFAQADNSTCLESTLLGSECTVSEQCTLKVAYSACLEGVCRCTDGHLQFRKHTCLSPAPPGHVCYSNEHCRLWDKESRCEFVILNLFGRCACNSYFKQIGDKCVAQKIPPYATEAVVAEMDTVVTTSNATVTYKDHIPNPTVQLPASSTNSFGSPLSVISSDDIQPSKLPLYTNKNDVFSTDEDSPLMQAVMKVPSVEPTKRLPVSNRKDGEPNETIRVDEMTANLHANDQPIYRVVTQPSVDKKTNKKGSASKEQSSGKPHKGGHQKKSSLKDKHRIRTDTPVYDLGPASLGMPCLTDPQCQQVDPYTRCLNKKCDCTYRTNSTSACSARNRGCLPNTFQCRSTGTCISWYFVCDGRKDCPDGSDEKCEGTGKELTGERCPTNSFRCGGPGSPCVSRASRCDGTPQCPGGEDEKNCRATRRKGCPRHTFRCGSGECLPEYEFCNAIISCKDASDEPPHLCNEQSRWRAADFCPFRCGNGRCRSTAVACSGRDGCGDNSDEIACNVCRCPAPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA21</accession>
    <name>A0A835LA21_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Exostosin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA21"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="10">
        <location>
            <begin position="103"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="11">
        <location>
            <begin position="450"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="63331" checksum="BD8EE42868B83733" modified="2021-09-29" version="1">MAAESLLKTGKHSKYTSYRKILYHRFFVGLLLFIVVSLVFTVVFNTFSGSATRIDVYQAVNLDSASFEVVKISSNALEAHPRVSNCTYWDCVDVYRCGKGGHNKITIYIYPLKDYQTENGNSISRFSKEFYMILDTIKRSKYYTPDPEEACLLVPSIDTLNQNSFSSKHVAQVLQSLPYWNHGENHLIFNMLPGSAPNYNSVVDLNTSRAIIAGAGFNTWTFRYNFDVSIPVYSSIAETIDSTQPERKKYLIISTQLNIPHNYLEELQNIASSSNDLLLLDRCKTDKTDYSKRCEYTTGTQFAYPDVLKDGMFCLVVRSARLTQAVLMDILASQCVPVVIADSVVMPFSSHVDWNKLALFIPEDNIKNLVKIVHSVSKERRGELYWQLRWAFDKYFASIEKITLTALEIINEKVFALAARTYEEWNMPEHLYGPVNPLFLPVTASKAAGFTAVILTYDRVDSLFALVSKLVRTPSLAKILVVWNNQKKAPPPSSEWPVINKPLKVIRTKENKLSNRFFPYDEIETECQLTIDDDIVMLTPDELEFGHIFVIEAIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA35</accession>
    <name>A0A835LA35_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA35"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="420" mass="49480" checksum="6F395AD08BC61C34" modified="2021-09-29" version="1">MMHCIRTALSIVCQNRNKVISTQTLFNVKQVTIRRWFSSQKDDPDIIVDNICNGDAELEKKLRILMLEVEVMRQDGRHAPDNIKKDHWQHLLSLPSKNQRASYLKYLFKTEKSRENFKAKKEAKKLNNPVIKPEDNKEYEDDLLYGIQHQSLFLRIRDQSINQFDNYRALQALTYGQSVVIDCSYEDNMVYKEALNAAKQLTYVFGDNRIHKEPFNLHMCNVNMGGHFMKQMRKNIPSLDEPWFPLNIHTESYLEVFPKEKLVYLTPHCREELSKFDHDAVYIIGCMVDKVNNEPLSLAKAKRDGIKMAKLPLDRYLEWAPGSKKNLNINHMVPILLDLKLTGNWEYSLRHIPRRKLMETKILAMQKKLSHNPKLQNEVMKNFKLAKLNKLSFKEKNFGSFTFKEKKNKSKRTLYDDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAI8</accession>
    <name>A0A835LAI8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25204" checksum="9BDD3C9891BA2D76" modified="2021-09-29" version="1" fragment="single">MIMMTFIDISRIVTLTFSQKYRNVTQEFLTKIHLFYFKDKSEYAMKVMFSIYYWLLPRQETSFTLSEGLTVISAKYSEEELVEVSKKLTGCVDYHRMIVKFTNKVSDVFGPMLFAYYIFHQTSGCLLLLECSQMTAPALMRYLPLTIILTQQLIQLSVIFELIGSESEKVLNAVYSVPWECMDPKTRKMLAFFLMNGRKPIHVKALGVANVGVTSMAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC96</accession>
    <name>A0A835LC96_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUMO-activating enzyme subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000744">
        <property type="entry name" value="Smt3 activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="17"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="339" mass="38464" checksum="8EBE7601E2888190" modified="2021-09-29" version="1">MVENNDIELSEAEAEQYDRQIRLWGLESQKRLRASKVLIIGIAGLGAEIAKNVILSGVKSVCLLDNEKLKEIDLYSQFLAPPDKIGENRAEASLTRARALNPMVEITAETKSVDDLPDSYFTEYDIVCATGLKQEQLERINNACRDSNKKFLCGDVWGMYGYMFADLVDHEYSEEIVQHKAVKRSSDETEKNARETVSITVKRRAIYVPLQNALSVDWMKPEYRSRLRRGDPSYFVMKILLRFKDEYNRNPDPAKRKEDTKILLRMRDELVKELSLPAGFIVDELLLDVFGTVSGAAAVIGGVIGQEVVKAVSQREPPHNNMFFFNPVKCVGFVELYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCA2</accession>
    <name>A0A835LCA2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="9070" checksum="F85A169D179FBA6A" modified="2021-09-29" version="1" fragment="single">NLFFKWAAVKHLVFNFKGFEYVLQKYLNPLQKLTAELPNHAIEMQIEFQEALPTYTKSKPQRRLIRIINPRKKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDB1</accession>
    <name>A0A835LDB1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032765377" evidence="2">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="16589" checksum="ADF18662DAB7950F" modified="2021-09-29" version="1">MLERRVLNRSLLTLLMSATEVIGDVADNMYTDHYQWRRSMLGHTFSVARVECPETTSGTVVHVVRSWLQTHEEAQIMVASILVVLGLWWFVRAVLSLLINLVCPLLVVVLAVVCVPQLRAPLLGQNYPLLANLIRNILLKMADNLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG32</accession>
    <name>A0A835LG32_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG32"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15720">
        <property type="entry name" value="FYVE_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03569">
        <property type="entry name" value="VHS_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000028">
        <property type="entry name" value="Putative hepatocyte growth factor-regulated tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="14"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33325" checksum="B8B99248622E4E03" modified="2021-09-29" version="1">MFRANNFDKLLDKATSNLRLDPDWPTILQICDLIRQNDCSKLAKFPTKERLKRHLVYLKYEHHKVQKNMSDFDNMSAEIVNVCYRPKYAVAAVKKKLYSSNPHQAMFALLVLESIVKNCGSGVHDEVTSKAFCEMLRDLVKTTQHENLRNKILELIQAWAFAFRNSPKYRSVQDTVNILKAECYKFPPLKESDAMFSADTAPEWADGEVCHRCRVAFSLMVRRHHCRACGQVFCQQCSAKQSTLPKYGIEKEVRVCDACYDKVSRPPQSTTKLEIVDTSNDYGPSVQTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG97</accession>
    <name>A0A835LG97_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG97"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="362" mass="41853" checksum="A50E1CFA51FBF637" modified="2021-09-29" version="1">MAEVNDRKNAVDWFGALPLPRKLAPLRFLSRPIVHKMSSPATPCKRKLICNQSKFNKTLPENNNNSSIKFSERQQARSFIAWYKRMIDNERYNLALYLSDDAMLEWFGRTIKTRKKVTAFLKYDMQCSRHDFTTVESIDKIQTRQETVQRKNDSILASPLHSPEIIRNKERCHKRRLLRSNCNSPEWAEGCQPQEEISIDNNQKTDNTSSDKEKVKETDHNPLKRSFPEDSEISSKGDGMRKVKRKCVSITPPNPEVGQGDCLPSTSGTDSDRSHDALNAQLPKLAVECNGYIEFTRTRNNRSTEAMKWERKCKVQISYSEDPLNVGEYIIWALRYTDESKCRRNLLAAFEEVAKEEALKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGS2</accession>
    <name>A0A835LGS2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGS2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="206" mass="24284" checksum="0C24954A13CBEA28" modified="2021-09-29" version="1">MSSLYLNIIFLACSINIGTAISIRGIVDTKNANSPLLRLPTWKVHPEIKSEGIFERFVRKYLDMLSTAFTGKQLIRYCRMMSKELSGFGFKYTEQLAKHFRYLSRMYRDGIEQEMAEYRKEYDEKLTNRQIFLDAMNDIFTLQENLRFDDYIHDMVDFGNDHIPTLVEQTRNILRMIVDCVHKLSAGEQKILEKKLVKAIKEYDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0M4</accession>
    <name>A0A835G0M4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000788">
        <property type="protein sequence ID" value="KAF9405197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0M4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="216" mass="24563" checksum="C20456F07EE1D5F5" modified="2021-09-29" version="1" fragment="single">KTKVQLSPLNINGFLNDVIRISAPVINEEALYYLHRPNGDVIKLDIKSPKLRDMKLERDVNPILVRYVNNVKATITQNDNYDVFAVYSNLPPNFVFDRKASEMEPNEFMIGPLCSEDHGNWVLKYVPIIPAKPVLNIGDTLNLSIAFPIPSLQTCELVVPRSTFDRFYDRNKIEFSTCGFSVPNLTRYDAGTWTIIAVGNIVYEGEARLEINKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1F8</accession>
    <name>A0A835G1F8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000668">
        <property type="protein sequence ID" value="KAF9405872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="231"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="452" mass="51442" checksum="0FD955E34CE01092" modified="2021-09-29" version="1">MEKISPMTMTDTGCKPSASQKMHKQRVTTGIQAGAKTLYSRATNQEARAHILSPDTRAVAMKRVSTMPEPSDDMEKISPAKFSTGILPQTSLARANTIAIMNALMRILSCTEKITQVLKVKQGKIWQHHSCKMGRLRTNCWLEEDLVMKHWMRILRTPHATDTEQSSDETEADVSTLAPQQPRGRTPFYTGKDRSTKWLMHKPLRNVRTRSCNIVIHLPGVKDVAKNAKEPLQCFSLFMDDSMIDKIVLYTNIYITKLHEKFSRDRDCKLTDTIEIKALIGVLYMAGLKKISHLNVKEMWLDDVGIMTFLVTYKRRSRCEEQIMNKIKHSMTGFTTPYESIDMNFNIPIKKLSPGRFESAQKLAVILLGIASPAYIIEALKDEGWGGGGVILPAIVAWHDDFRMEALNDFSTKFKILVDELSMYMQPVGFPIELVARLVDQHQRRNRSIQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1W2</accession>
    <name>A0A835G1W2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adapter molecule Crk</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000907">
        <property type="protein sequence ID" value="KAF9404689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1W2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11759">
        <property type="entry name" value="SH3_CRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035458">
        <property type="entry name" value="CRK_SH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9404689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31502" checksum="92FDF754C96DD97B" modified="2021-09-29" version="1">MANTGIGVSFDPNDMTSWYFRDLSRAEATRLLLNETESGVFLVRDSKTITGDYVLCVREDDRVSHYIINRVVSADGTIRFRIGDQLFADMPALLAFYRLHYLDTTPLVRPLPQALAKVAAPPPQQPHQVLELDADDLPFRRGERLMVINRDEEQWWTARNSLGRTGSIPVPYVQRILDPSGVPYPPAEALNHLADPPSPPSNKHPQQRTNMQRTLPALARVKQPRVPNAYDKTALKLEEGDIIKVTKININGQWEGELHGKIGHFPFTCVEFLDENQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G371</accession>
    <name>A0A835G371_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000775">
        <property type="protein sequence ID" value="KAF9405250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G371"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="164" mass="17487" checksum="FD4A2AC0D4E3A742" modified="2021-09-29" version="1" fragment="single">MYSVDMAGGAFAVACGTGWKLYSWRRRSKGAWFSGTSRTLLFPLESSCLRIIVSAIVLRNVIGRPVDLLIGADVLGLLQLGSSKLLQSGGLVSVATDLGDIIMGPVLSPCPLQGEDDNLQVGLSLAECVQRFWEGRAPFCSSSKPRALGMRIVLPEQHGSFCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3N5</accession>
    <name>A0A835G3N5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000778">
        <property type="protein sequence ID" value="KAF9405229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3N5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039149">
        <property type="entry name" value="ZNF800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="806" mass="91997" checksum="AA575F0647F3C06D" modified="2021-09-29" version="1" fragment="single">MRKSSMAGNKVNTKTKAKEDRNKANSKNIGQTNEDSEETDFALLRKPIPTSITGFGQARKIFDLATEEVCRNIFRSLANFISHKRVFCKEKFSSSLHSHFINATSTYNELLKIKHLEQGYQASLKENVEKDSNDVDDRVPLTKDLTAIVEKIAKNKGVYQNNNEEPEIALQKIPNSSVAVFQSVQTSRRQNENMKAQVNELDNILSRDIAVLQSDGNFKVKSSVSEESDNVIQISDDEDNNDVTDILKCKICDIQFSTQKTLKFHMNYKHVETRLVYPCPDCLEIFSTSWSVYRHLFKVHRKTAAQIRRLRESIQAKAFKMNNPPAFYEKRKNNMKITAQKISEEERLEQENQAWMDNMEGDGELPRCGGCGRTFERRAALAAHTHTCQPRSRALSRRQPETKKIEIQIRKDYHKGPPVNLNLPIKITDANENKITKDEQQAVPKPKKEDEKQIVIEDKDVDEDKVVDDDKVVVDDKVVLDDDKVVVDDAAMDVSDDDSKSNDATESPEKVPEKRQIDPPKLNIRLPFAHQAEKSNRTAFRQRIQSEIEITKMLCKRCDAQFGETQELYDHVAEHVKWMRYACKLCNFKHYFFEKLPEHVKVVHKLKGDKDFYYSTVKAIDGPEALELCESTDELPDATETSPESDVRAGALFSSSTRVEGLSRKRKVFHSKTNAKKRKEFIAKPVQDKDGDSSMDKSISLDNYSSTNIKNFEENSSDLDDIDAKKHVSNDNTDSITMATAKSGQTKKKAQQEIQSNYDNLNKECCGALVTLSKKSVERSAAHIKTDFSTLCPKKILDFQMYLSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4J1</accession>
    <name>A0A835G4J1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000810">
        <property type="protein sequence ID" value="KAF9405100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4J1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="302" mass="34267" checksum="B081AD8163BEB33A" modified="2021-09-29" version="1" fragment="single">MFTITTIKVNFNKDSDSRKNAEYIKKRLGALDALWEEFEQNHSRISDHASEADEYFRLNTYQVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQQTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKLDDEELLLTTLSINVRCSDGTYITLRALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQSKGLVSIDCQSIYGDYNFTTEALVLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4J7</accession>
    <name>A0A835G4J7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000587">
        <property type="protein sequence ID" value="KAF9406471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4J7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="63"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="315" mass="33648" checksum="886AE0BB9ADA9B9E" modified="2021-09-29" version="1" fragment="single">IPAAVDPVITKLNPEGLRYGYIRDDEGIPHLVDSWIKASDLRNMARYNPDKEHLLIVRVSLRSNPLVSQPIVQGNNALLAASNFDPNKRTIILIHGFLGNILSGFNTVLVPAFILAGDVNVIVVDWGKGAHLGFNGISSGRSVGRFINWLNQASGANVENYHILGYSVGAHQAGIVGRSLLGRPSYLTAMDPADRWLSSQAVRADDAVYTEIIHTNIGNIGQEEPAGDVDFYPNGGINMPGCSTAVCDHYRSYFYMGESLATGGFTGIQCASVEEAKAGSCSGPATLRMGGLQPKTGSKGIYYVPTNGSPPFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G585</accession>
    <name>A0A835G585_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000636">
        <property type="protein sequence ID" value="KAF9406140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G585"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000685">
        <property type="entry name" value="Serine/threonine-protein kinase dyf-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="45386" checksum="CFD2EF845F6E786A" modified="2021-09-29" version="1">MRGNLYQLIRDAERAFPEPVLRNIVYQVLQGLAHMHRHGFFHRDLKPENLLCAGPELVKIADLGLAREVRSRPPYTDYVSTRWYRAPEVLLHDTRYGAPIDLWALGCIMAELYTCRPLFPGNSEIDQLHKICGVLGTPDRDDWPEGYVLADALRFRFPSSAGVPLARVVPSASPPALALLTSFMRYAPRDRPTAPQALRFPYFAVGAALVVPPPASRARRSAARGEAENLAEETRSPSTTAPLHAAIQPPPPHLRDRFADILGYYFYFLNKSYTGEVVHEAGAPAPLRRVSGGRSVLAAAAPAPRARPALGGAAAAYLSAARYVTGSRIDTSLFRALPLRAHRAKRTMFRAAIQFESYYTFSITTYKYFSETDETIRMSEETYSSTPDMCLILQDGKVQSAGDYELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G678</accession>
    <name>A0A835G678_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000545">
        <property type="protein sequence ID" value="KAF9406828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G678"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033003364" description="Cuticular protein RR-2" evidence="5">
        <location>
            <begin position="24"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57457" checksum="15B6CB46C018598A" modified="2021-09-29" version="1">MRLTVQMKAAAILLIFHITATRTAKTNAPSVHEIINEQSRIDDKRPLSYGNPLAGNSQQNAKLHAQHQQAMFNAERIRQHRAQIQRWNAQPQQGDSYMRAYHESQENHQLALEQMQATQREKKPKQRQERTHLRNRPSLDPVKLTRADAVDKNRNHRSYGSVYYNNVQPKHKVNTSPGTTYDQGVTIKPNGNIGLNNLEKEQTGLYTEVSPSKTQYVYPKLYHQMHSYQSADDISALNNLLTKTPQEQVSELNTLTHMNQEYGKDNLETPIDLYFYLNNPNGLNIVHDNKIKYNVDNAYAGPYATEYVNYNDHKPITEEVDDIEEDKVPNLKFQPIPQTPTVMPHVFEDPTTTKSNYYKIEVEQTISGNLHGNGVEFPVQHKPSYGAVKYEKPLNIYHQEASTEGIKYLQAQQAGVQHLSQDGTGVSAYGDDDIQYAANYEFGYRVRDHETGNDFGHQEAKSGDKTHGSYHVLLPDGRLQQVKYSAGPDGFHADISYDHLQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G682</accession>
    <name>A0A835G682_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G682"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="641"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113978" checksum="C2548C45B4F1441A" modified="2021-09-29" version="1">MSLARTLIRSSNKYLACNSKQCLIQTKLSLSSNAESFLCGANANFLEAQYLDWSKNKGSVDSSWDGFYNSLCGPALKIEEVQDEFSPQTVKPTSKSGSKDKEEEYRTKIRLNLAVASLIRGYQCRGHLLAKLDPLGLSSPSQFVACEKKMALEEKSLKSHLVAYELMRELGEKHMDMVFELPSETCIGGEETQLTLREIISRLEKVYCQSIGIEYMHMYDVDAVRWLRKKMEMPGATDIQDCEKKDIMRRLTKAVFLEKYFASKWPAEKRFGLEGGESLILMMEEIVDTSTKLGVESIIVAMQHRGRLNMLVNVCRKQLADVFAQFRPLEPKESVSGDVKYHLGTNIHRFIRRTNRYIKVAMSANPSHLEVVGPVVSGKTKAEQFFKGDSNGDKVMAIIMHGDAAICGQGVVFETIGQGSLPNFTTHGTVHIICNNQIGYTTEPRFHRSSPYCSDVAKCVDAPVMHVNADDPEAVAYVARVAIQFRCKFKKDVVLDLVCYRRHGHSEEDEPMYTQPFMYKKIKTMRTIDLMYADHLKATGIASEADIKKWEKEYTDTLNKHFEMSKKITKLSIMDWVDTPWTGFFENVNPNVIKETGISQQTVATITSHFVKPPDPWAFELHPGVTKILENRAKLIASGIADWAIGEALAYGALLRDKVHIRFTGEDVERGTMAHRHHVYHHQSVDGATYRVLDFLYPDQAVYSLHNSSLSEYGILGFECGYSYSSPYVLSIWEAQFGDFADTAQPIIDTFITNAESKWVCQSGLVMHLPHGIDGGGPEHSSGRIERYLQQCDDDEEAIPNLDDKNMALKQLRAANWIVANPTTPANYFHMIRRQIALPFRKPLITFSPKVGLKHPYFRSPLKDFYLGTSFQRVIPEDGPASKNPGGVKKLIFCSGNVAIKINDARKEKKLEDKIAICRVEQLFPFPYDMVLKEFCKYEKAKKFWCQEEHRNQGPWLFCKVRMENLFQQKIGCISRPSSPASATGIKWVHMKEIKDLKAKMVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G687</accession>
    <name>A0A835G687_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005094</name>
        <name evidence="3" type="ORF">HW555_008153</name>
        <name evidence="2" type="ORF">HW555_011005</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G687"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19814" checksum="B43309A53539C855" modified="2021-09-29" version="1">MDSETITASALLLCSLAIYSYALKKKRIIQKKHRKRRWWITTIHRNRSSATMEKLLNELVAEPSDEFKKFSRMSLNDFEYLLSRISRRISKQDTQLRKAIPARIRLAITLRYLATGDDYGSLHYLFKVSPQAISEIIPEVCHALCEVLKDEIKTKFHFFTHLYTTRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6H9</accession>
    <name>A0A835G6H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DIRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000464">
        <property type="protein sequence ID" value="KAF9407508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033471">
        <property type="entry name" value="DIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010561">
        <property type="entry name" value="LIN-9/ALY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689">
        <property type="entry name" value="LIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689:SF2">
        <property type="entry name" value="PROTEIN LIN-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06584">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01135">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIRP" evidence="4">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="287" mass="33322" checksum="FE44A49DBBDD2CF9" modified="2021-09-29" version="1">MYIHLITAKMASTVQTVILPRHHTSRLIAPVSYHYINMADKSERDPDGDDFSPRSHYRVKDEPMDMDFPEEEEEPPAFGPAALGLHRVGTKLPPKPAPSEPVQKLNARGMPARIRKKNRFIFVDDFVNTSPPRQSPKRTPKIIAKTPNKQPSAKKQKSPTKVQRSNDKYDEKVEPAGTQSPDNRSGHRIGMRLRNLLKLPKAHKWVCFEYFYSNIDKVLFDGENDFMICLRESFPQLTNRKLTQVQWSKIRRMMGKPRRCSQAFFDEEKRIRKKTQINKVYTTKESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G713</accession>
    <name>A0A835G713_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000460">
        <property type="protein sequence ID" value="KAF9407551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G713"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="456" mass="52248" checksum="3EB8C237F78573A9" modified="2021-09-29" version="1">MRLPPISPRRSFYIIVTAFTILTLTWYKDSSCMKFPEISDLEYAATSWQLLSLENGSVYFYGAYWDPRFEEPLVRILVYSDVSPLPKLYCQLWFPNDNEPQTELATPVYGWQTAWYGPVMGVNEPYILTCTCRRHPPEKEVAPVAVSVVTGPCGETSNVLNIQNAPFSKHINKRTGMSSHRNDSPIVVCLKWLHYRNDISTSLVEWLQLIKHFGADEVYIYILRIHPNLRKVLKYYVDQGFVVVTGFDHAPQVSGLKQSRSTRDFHDLRRELLPLNDCLYRNIMQHAWLLAIDLDEMIVPPANKTWSSMIERLIANTTNGQENKPLDALVFQNYFVIDGAQVDLEGPAKTRILSHTWRADAPSPPGSMEKSFVNTSSIIAMHNHQPLVCHEPCSVKYVDAAGPGRLLHFREKCSYNEKDCPELHDVVKDDTLGSWRQTVLEEIKHVLQILDLDPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7C5</accession>
    <name>A0A835G7C5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich melanocyte differentiation-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000405">
        <property type="protein sequence ID" value="KAF9408142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27621" checksum="AF5D15F3EC798D7F" modified="2021-09-29" version="1">MVVGFSYPSVQPPPDEGVISVDVSRDALVDSMTDMSETPIPPDIITSVVTTTENEDENGRLTLAYERLYEIPKTIVERNLDALVYFKSLTSLIADDNPLTENCCLPPLPKLELLWLNRCKIASLYPWVGKLKESCPNLQYLSLMGNPAAPSYFNGGTFYEYLQYRLFVISQFPSLNHLDDRRVTEDQRLEAQRLYKRPFFERMVKPAGLSQIVNTSVTWNTFQNKINNFLGKDKQGNRNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8I8</accession>
    <name>A0A835G8I8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8I8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9955" checksum="01B60A58C76D29B0" modified="2021-09-29" version="1">MILHFCFTVVTEYKNRIDKLLTETQKAHDMEKERFKDVMDSCVAMKQQSTICQSQFEDLQIECKKVREDYNKAIKELEKMKSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9C1</accession>
    <name>A0A835G9C1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9C1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35617" checksum="90AE32B7A8AC7EEF" modified="2021-09-29" version="1">MKIDTERVIIEVHLRPCLWDKSHELYKNRDARSAAWEEILKELEPNFESLSEEEKKNADKKIQQRWRTARDTYSKEKSSDKKQPSGSASQKKKKYSFYDMLTFLDKTTDIDVDETLSEEHTQDSSLQSGNTDSQTSANKHQPSSTIELVQEQSSTETQPSTSGLQGINERTGNAKKKPKRANSEFEAELLKLLKSSELEIAPDDLAFYKSIQPALNRFNSYQKLMFRTKVLNLLMEMEHQIQSLNNFYQQESIGTNNESNYDSMSPFGDLNQSLHNTSEGDENIIVSALVNQDIVDTTTSGTDSLQHNSNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA03</accession>
    <name>A0A835GA03_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="66" mass="7333" checksum="CD1A8D453DAAAF2B" modified="2021-09-29" version="1">MGNVGTVSEETLDDPHSRRAEQSCAVKGGRQCHNSQRLRCRVKTTGFSTDFISNINLLNRKALSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA45</accession>
    <name>A0A835GA45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM187 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43940" checksum="A8B791DA3E14BBE4" modified="2021-09-29" version="1" fragment="single">MYGAVRDVVKWDNIDLDNFMYPRGDKRKLSILARAWQQYYECSAQQEDALPAPRLLANVIIMLFQGAVARLPCDLCTEPDSVDRLTTSIEDFSEIESYDRLSMEGKVMTIYNVMPEDEGVYWCRDGDGHGGLVIVEVVDNESYTVVKPTTSRGPHPVAAEAYEGVILFTQWSEWSECSVCDKVGPETSVRNLLRQPRPEPYYLLDSEKTAARIKLMELDDKLIDLFQAFPGGIPCRSQYLPQTMKALDFIQERPSEIMIAMCKVPCAETSSLQNLDSLFDIYPVNYQLPKQPPPPVSKTIFANLGQRVTLRCPGTTLRDVPVQWRVGGVGRGVGGGALVARQAWAAGRAHVAARGHLVLHAALLHDHNLYRYTHHYTNMIYTLPITKLSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC89</accession>
    <name>A0A835GC89_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_007734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC89"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="13">
        <location>
            <begin position="282"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="419"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="539"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="12">
        <location>
            <begin position="619"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9414337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="891" mass="101816" checksum="A053FEF8CA3C601A" modified="2021-09-29" version="1">MIEELKMSLKTDKDGKPNKCKVCSLRNVEMDHFETEKHKQNACLKQYTTNKSQFIINRKKVVSVCCEVTSSTASTNSIHGKIKVSVKPDEPVQFKFTLTNESRTNCLEVVEIDLAHLKFNFELPNNPYKPGCEPYSMPPKTKLPDKIVVSFKSPHIGQYETPILFNLKRKDDSDETIVLLREMVVFVEKTVSLHDNIISPYERKKVWAKDKSDDIFGIPKTCKKIYANKLNVDDKASEAEKDLASDIRHTFDVGITEDNYVKFFHNLLWYEETVIRVNIKNYNMSRATMKIQPNPNYDIVYSLTVPGLSEKRPSLMIGDLLFVRPHNQQEVMFEAIVKEVNENEALIGDLHAKFTNYYAMDGLFDIRFFLSRISLERMHKAVNDIRNNGHYTRIFPKENECVKKAPPILNYFNPLVEANLEQRCAVECIVTNSSGTAPYLLHGPPGTGKTITIVEAILQLAISERNYHIMVCTDSNMAADHVASMLIQYSHLFPKSNWLLRANSKFRNWETLPKCLLKYSNGTSRHHFINIAIKDFMSYRIVVTTLSHAAKFGRLMARRRIGHHISHLFIDEAAQASEPACLIPVCGLLKKCGSLILAGDPHQLGPVVISRNAAEIGLGTSLMERLKKDNSLYSDSRNDPNYVIMLRNNFRSHPDILEIPDKLFYKGQLRACSTEDPLSTTDILGEKETSRAIVFHGVLSKEERIGKSPSFFNTMECEMVLQYVKRLVQVHEVPMSDIGIVTPYIRQVYQIKKSLTECGFNDIEVGTVEAYQGKEKRVVIISTVRANCNLLDYDAKFQLGFLVDDKRFNVAITRAKAKVIIIGNPLCLEKDVKWRMYMDRCRELGTYHGFDSKIVSDDSSQQIIDKLGQLIQHIGNYCERDKKLNFKFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDA1</accession>
    <name>A0A835GDA1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000156">
        <property type="protein sequence ID" value="KAF9413527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDA1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="27196" checksum="F47EA11D54BF7E1D" modified="2021-09-29" version="1">MESPLLDSKNVEVTMNRSVSSSSNQLIPDNLELPDDTFRMSLDNYSMIGENVTIGREMSVDGSVGANAETPTVELPTPVQTPEVENSTVTSPDIETPEIPSPDIVETPGIESPDIESPAPEKSPPIIDTPKTIEKAETRRPQTLLQLSLSKKSDNDIFVKPSPVADLMSPAKMLQFEVEPSSATPTMKRAAVDFDFFSKHNFDEYFAESEAKCNNEAEDPGDSSTFKETPVIVKADTVRHEIAYGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDB2</accession>
    <name>A0A835GDB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF11">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="381" mass="44106" checksum="7F357A820230C4BB" modified="2021-09-29" version="1">MNPSYQLQTLLQPGTASVAMPPSQPQGKPRQLLDYRSWLCMQPASWAKSQPSKFLPRKPKRVRTGFTTSQLNELETEYAKYRFLSQPRRMQLANRLQLKEHSIKIWFQNRRMKEKREFAEAQESFGDVYEAVQQPMLYYTNVAQTYPVENVPSVQNCTSEYYDYSHYMHGNNELFVSPSNVQESPEPHVLSHTQTEITSLGSTQKEIVQNLFLIEQQYMARYTVPSPTEDEHSSPYFNPEQSCMYGDTTPFASIPEQHDHSKCIVYPETEENLSIEEQLIPLLDSQEVTSLGYTKEEIIRNLFLLEQQYKARQTGLAAPTDNVLSPQHFSSEPSRVYEDKVHVETEGRPPAAVQRTEHIPADLIDVPCSTYFEDVNIHNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDC4</accession>
    <name>A0A835GDC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="56587" checksum="41180E2A7F4C7EBE" modified="2021-09-29" version="1">MEKCRICLRHRKKLLSLSTKLNGITFGEMMSAIANIKISNEDSCYDKLCRHCREKLIDAYNFKIEIERSEMILQETSNRKRICFSNLRDIKIDIEIDTDFKPILPAIDNFYQKLIENGTNTLSYNDTLIKKIEFPIESCKENIQSLSVGEFLNSIKNESDNDCDYQAYEIGANDYYSESGSNYSISEIKKKKKKVKKRPKATGSKINERTEKNKEHQKVLEKPLKPKFIEDLRVVRTESDVKNKRNRVKKPKASKLKVCPYCGKLSKSLDYHILIHTAERKFKCDQCGSAFFTLSVLNSHIKRHAAIKKFKCGQCIAAFTTEAGLRNHTIMHQDEKKYVCNVCNKSFKRKPILTRHKMIHNFGSKPIQCELCPMTFNTKYNLRHHMRVHTGERPFKCEICSQPYSYKHDFNRHCLKKHGVFLKRRSVRVMNEEVLQQERALMRELSLRAHGIIKAGEAENPFDGPQAALAYEQAIKAIEANKIPIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDC9</accession>
    <name>A0A835GDC9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDC9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="17882" checksum="29B2B1F3A443D449" modified="2021-09-29" version="1">MKQRKDIRIECYSPPGLHFINDTPFDLLPRDPQANASVRMCGNINWAWPIPSGINIKTCPSTYCMCPLEPHTNKAKHTEPDTGTTFPVGFMDRQYRYGCTIPESNMEVFSREDLGGVIVGYWKKVEELLYLTEWQREMYPHFIYVWIDDGGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDH9</accession>
    <name>A0A835GDH9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDH9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032940668" evidence="7">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="119"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="330"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="562" mass="61604" checksum="96CB830C69172450" modified="2021-09-29" version="1">MSPFVIVFCVCLAACAQAASVPMFDLEAAEEHFERFIQDFNKQYTSEEEKQTRFTVFKENLKRANTFNAQSEHASFGITQFMDLTVKEFVSRYTGLDANLNFTGQCQVVTDADLPNVNVPDSFDWREKNAVTKVKNQGQCGSCYAFSASGAVEGQYAIKYGKLQEFSEQQTVDCDEDSLGCGGGLMTSAFSSMIEEGGLESESDYPYIAKSQSCQFQASKAAVELTGCINYNLKSQEKLKQLVATIGPISIAVKGAPFLTYKGGIISDDACNEGDVNHAILLVGYGTGITKFMDLTVDEFVNRYSCIPANFNFTGQCNVVTDSQLPKVYVPDSFDWRQQNVVTRVKVQGECGSCYAFSASGAVEGQYAIKNGQLLEFSEQQTVDCDKGSGGCGGGLMTSAFSSMIELGGLESETDYPYVGQAQSCQFQAGKAAVRLTGCNNYNIQSQERLKKYIKNRTSFTIHVTPTFLTLYIKWTNIYSVKSAGFHLYTGGVMNDQDCNTGEVNHAILLVGYGTENGMPYWLAKNSWDTVFGENGYIKFPRGDNYNSCGVMNQAMASPIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDL4</accession>
    <name>A0A835GDL4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Signal recognition particle 19 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_018147</name>
        <name evidence="11" type="ORF">HW555_007893</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000142">
        <property type="protein sequence ID" value="KAF9414134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000281">
        <property type="protein sequence ID" value="KAH9640481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDL4"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 19kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9640481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16758" checksum="5F25AEFDBDB19769" modified="2021-09-29" version="1">MAAMISSWNPEKKHSDVERWICIYPAYLNSKKTLAQGRKLSKSHCVENPTHQEIRDVLVAAGLRVGVENKLYPREPSKEILYRGRIRVQLKNDDGTPVKPEFPTREAVMKHIGESIPKLKTRQNRPVDQQPQAAQASHKGKGKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDM6</accession>
    <name>A0A835GDM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000192">
        <property type="protein sequence ID" value="KAF9412348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="305" mass="36048" checksum="DDEF1C92CE0FBC65" modified="2021-09-29" version="1">MAAKVSIPFEKMADILINSTQSVFKETYDYYLWTLSLSDNRTKGWPLVDSPAPTVFYTLMYLFIVWIGPKLMKNRRPFQLTWLLVPYNLAMAALNAYIAIRLLTASFRLRYSYICEPCRQKYDPDELQIADAVWWYYFSKLLEFCDTFFFILRKKEEQLTFLHVYHHSTMFSFWWIGIKWVPSGSTFLPAMVNSGIHVLMYTYYGLSVFGPAVSKYLWWKKYLTIMQLIQFTCALLLGINGIRTGCEFPLWMHYVLIIYMISFIILFGNFYMKAYIAKGSKCMEVRYGQCLDDEETIAKRKLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDP0</accession>
    <name>A0A835GDP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_008051</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JACKWZ010000149">
        <property type="protein sequence ID" value="KAF9413848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDP0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="830"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="689"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="776"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9413848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124065" checksum="A0223A2AE0CB1611" modified="2021-09-29" version="1">MKGNKVSATTQTRQIDVGSPVEGEKKKHNKIKTSKYTLLWFLPKNLSEQFRRIVNFYFLIVTIISIVIDSPVSPFTSILPLSFVVLVTAVKQGYEDWLRHKADNKVNNQIVEIVHKGVINEVRNSSIAPGTLVRVRRGKEVPADLVLLCSAGDKGKCYVTTANLDGETNLKTLRVPPPLVGFTPDILPHGMKIEVPHPVADLYTFYGRLEIPYKDSLVLTPDHLMLRGSRVKNTEWAIGCAVYTGEETKLALNSKYTGNKFSSSELAINQSLLWFIGLLIAEIVVSLVAKLWIERRNPERDLYLGPGSPIPAPFGDILQDLFSFLLLYYYIIPMSLYVTIELYKFIGSLFIAWDEDLRCEETGRPAAANTSDLNEELGQVEVLFSDKTGTLTKNLMVFKACSIKGQMYEEKESKLYDVERFDEPVDVFQTDIKFFFKILALCHSVQVSNEDMKKLSARLSVTGNMQLMSFFKRKKIKTNNTNGSVVDNVTWNSIINENGNKIDYQASSPDEKALVEVAERFDITFLGEEGNDLLLKVGEHTEMYERLQIIEFTSERKRMSVILRDRDGKIWLFCKGAESSVFPLCTNYSCVQETDRDINIFANKGLRTLAIAYREVPEDEYEKVAEAIKRLDGKNAESLQQVTQQYRALERHLTLIGATGVEDCLQDNVADTLASLRAAGVKTWVLTGDKVETAINVAQSCAHISENDRRMFMIGVEDNTTLQAHIDECSRIISEPSYRDLTLVVDGTSMTQVLDTEYAPAFVNIAIKCHAVLCCRLSPIQKAKIVKLIKESSERPITAAIGDGANDISMIQEAHVGFGILGREGHQAGRSADFAITKFSMIKKILLVMGHWYNQRLATLIQYFFYKNLVLGNIMFLFQMQSVFSTQSIFDSMYLTFYNLVFTSVPVLLLSVTEQVWPSAVLYNNPPLYSSIKKNKLMSWPYFVSWCVAATYHSLVIYWFSYLAFKNSIINLDGKPVDLWCYGAVTFHLLTVIVNLKLWLHARYHTLLFVLSVVLSIIIYMFFNTAYSFMYLQIDGDVLGTYIRLLSSPGFWFLNLVVVVGCLLPDFFVRIISERLIRTRIMKRPTEPTVFVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDS3</accession>
    <name>A0A835GDS3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="4"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="487"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1509" mass="168339" checksum="0A480324E3514288" modified="2021-09-29" version="1">MTINVFGFLSLNTPKIPGNAGLRDQVTLLRWVQRNARAFGGDPSDVTLAGQSAGASCAHLLSLVILMSGSAIPAFYTVSPIYAKQAATRFLTILGINSTDPDLIHDKLVTTPLEDILNANTVFQYESGLATFVPVREDQRFENERIVDDDPITLIEQGRGKEYPMIVGFSNNECEFFKRRLLYLDILGRIKANPLVILRLEIPFTTLPNVALALANKVIDWYFHGKLNIEDYLEVCRDTFFVYPAFKVSEWRAKMHEAAPVYLYQFAYEADFSAVKAGLNLEYNGTAHVEDLTNIFRENALLDDRQSFPPVNRDDSMKDWMTQFVTEFMNCDKPTCSESGWYPVQADHLNYQNIQEPTVYDNVVPTKCQGQIIKFFDMIEQIASFSSILCGNSQARPFHGQRTILINVVLVVATSALHLNEHGIHYDQISTSPSALNDTSDPVLAHTVAHSVNLAASDEIIEAVADNATYEKLFTYIDIQYGTFNSLFEAPVAPKRSDTVHEIKEHASQCPQLQEDKDVGDKDCLTLSIFKPTDVKNVSVLVHIHEGNFIGESADPAIYGPEYLVSKDVILVLPNYRLGPLGFLCTQDETAPGNAALKDLSLALSWVKTNIEKFGGNPENIAVSGSGTAGALAGYLALSPMSRENVHKVIIESGSVLSHWAIDRDPISTARLVASKIENFKSFEDVDLKKLLKAAKNISLRPCLEKTEEPFMTETPWTILEKKEIKVPFMMGTAKFAGVHEFISLTQNNVQEINDDVGLLLPDDLHFTSGDERTRIGHRVKTEYFGEDAISLSSVEPLTLYYTDAAYLAPTIRTARPLVASGATVYFYEFSFVGKLNIESQAIKSTVNGAVRGDIIGYIFTQDGVEPEESTDERAMVDRLVGLWTSFINTGTPTATGITWEKFDNEDPDEEPWLSIDTEVIQSKGMHVSRMTLWAEIYNEYFVEKSLAYGMSPSICTVLVLQALLSHLGVVLIVSTVTCVTMGRPTPVPRVHRDVVTLQGTVRGYLASNPPHFAYFGIPYAQSPTRSGRFKDPEPPPKWDGIFEALHKIKCPQLKADGEENCLVVNIFTPEEKAATLLPVIVFVHGGEFQNGWGAYRPPRQFLEEGNNVIVTFNYRLGSLGFLCLKTPDAPGNAGLKDQIAALYWVHRNVQQFGGSPQDVTLYAIEAGAVSVQLILLSGLAEGLLHKVILESGSVLSPAALQYDPLDAAYKGAASLGYKGSDDPNELYEFYLHASDKELVTIPESFLPCVDNTSDNVHNLIDLDPIQKLEEGMYTKVPMIITFTQKDTKSILGTDLQRFENPPDNFEYLLPNNLEFMKEEVKSEVAKIVKKHSMAHNYAYYIQDILVDYPTIKAAIMFAAKNTYPVYVMKFSLPKTSWDSILTQSLTTCIKKKKQSHFLVELVTMLIRNFKTLGDPTPLTTTLIPILWEPVSSDGDSISNMHVLHFGPSSRITMSSHNNPRLKFWDKIYTRFHSANDVTQDETEDLLNSKDIDDHDDNDLYRLAFVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF00</accession>
    <name>A0A835GF00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000151">
        <property type="protein sequence ID" value="KAF9413778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF00"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF264">
        <property type="entry name" value="MIP05773P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033061400" description="Sulfatase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="595" mass="66829" checksum="8AB1598E1A63D19A" modified="2021-09-29" version="1">MSLKFYVLASLVVLIKCESLSKPNIVFIVADDLGWSDVSFHGSDQIMTPNIDMLAYQGIIIPQYYTDTRGTPARSALFTGKYPLRMGTQGISIASAEDRGLPTKEVLLPQYLQELGYATHLIGKWGLGKSREHYLPTNRGFDTFYGFSGSSVDYYTYNHTWNETVFYGLDFFNNLEPVEDQRGHLTEVLTDRAVKLIRNHDTSVPLYLHMSHAAPHVGGGFVNLQTPEDLIAANDHIAHSPRRLYAGLVTGLDRSIGHVISALAERELLNNTIVVLISDNGAASTGLNRNFGSNLPLRGTKGTPWEGAVRTTAVIWHAAIPSKIWPGLFHVTDWMPTLIAAAGGEYNSTIDGFNQWNALTKDEPSPRQDVLITTDDLKEYAAFREGNYKIIIGKVEPQQSNYYGMELKKSRIPGFLYENVLLSSDTARVFRETLFINIDLEMAATKRNYSDLYRHINNTDAERLCIPTNAKGCLFDLSVDPAESKDLWDTHPQFVQHMVLRLRAYWAAINPRQEPTLDPRANPALHDFIWLPWLDNLENVSKPLLAIPNFPLQVSVGELQYLVDFNLNAFKESLTSYVKSSADSFIQNIAKLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF48</accession>
    <name>A0A835GF48_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF48"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="649" mass="74118" checksum="934167D89F71893A" modified="2021-09-29" version="1">MARLQGNVFLRQAEIDTPLEDPSSSDQVYKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNIKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPALDLETIQLALRRGTERSGSSVPPILNRMETLEDPPTYNRTNKFTSAFQNLIYAYGVATYREVNPAPYTIITFPFLFAVMFGDLGHGALMAIFGFWMCYKEKPLQAKKIDSEIWNIFFGGRYIILLMGLFSMYTGLIYNDIFSKSLNIFGSSWRNNYNESTLASNKLLQLNPDSEDYIQTPYPFGIDPVWQLAEANKIIFMNAYKMKISIIIGVFHMLFGVCMSLWNHLYFKRRISLYVEFIPQILFLTLLFFYMVLLMFIKWTTYGSTPPFYGSDDPEIVKTSAYCAPSILITFINMMLFKHDANTRPVCDDTMYAGQMGLQKFFVIMALLCVPVMLFGKPYFIMKEQKQRARQGHQPVEGAAENGNAGGAAAPAAHHHDEDITEVFIHQGIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVAWNMLLRKGLMSTDYQGGIFLYIVFAGWAAISVSILVLMEGLSAFLHTLRLHWVEFQSKFYQGEGYLFQPFSFEVILDSAGQTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF86</accession>
    <name>A0A835GF86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="61" mass="6817" checksum="EA352787DBC8900E" modified="2021-09-29" version="1">MFAQVEVSQGILKGKVCETVFGKKYYSFEGIPYAKPPVGNLRFRAEKIAVCAMDIDESKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFK3</accession>
    <name>A0A835GFK3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phe-4-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_007781</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine</text>
            <dbReference type="Rhea" id="RHEA:20273"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="EC" id="1.14.16.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000138">
        <property type="protein sequence ID" value="KAF9414238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFK3"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04904">
        <property type="entry name" value="ACT_AAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005961">
        <property type="entry name" value="Phe-4-hydroxylase_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01268">
        <property type="entry name" value="Phe4hydrox_tetr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="15">
        <location>
            <begin position="112"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9414238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="457" mass="52250" checksum="8BC2215EF9F0E25E" modified="2021-09-29" version="1">MMRVQPEREEVKLSSSPPDKPKLMEGGNYIREGRDSSKSTWLLFSPATPDEAGALAKFLSVFSSHGVNLMHIESRSSARRPGYEFMVECEHGAGDFGAALDELKNNVGYLNIISRNYKDNRYAVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDPEYRARRKYFADIAYNYKHGQPLPHVDYTEQEIATWGAVFRKLTELYPTHACKEHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSRPLYTPEPDVCHELLGHAPLFADPAFAQFSQEIGLASLGAPDDYIEKLATCFWFTVEFGLCRQEGKLKAFGAGLLSSFGELQYCLSDKPELREFDPDTTGATKYPITEYQPVYFVANSFEDAKEKMIKFAQKIPRDFGVRYNPYTQSVDILDSPRQMKDLLREVHQEMNLLLNAMDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFQ4</accession>
    <name>A0A835GFQ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Upstream activation factor subunit spp27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFQ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39917" checksum="7EA58968CEB88054" modified="2021-09-29" version="1">MSDSETEISEEVLQKEITEILKHASLENTSTKKVIQKLEKKLGVDLSSKKKMIDQIVMDIVNNMESEDEDMDESSDEEPKKKAPPKKVKKEDDDEDDEERDDSNDSDWGSDVRRIFMNSECSDECSCTPQDPHIPINIKRRIIRKHFTDQPRKGLILKRVAPNYSDDETDLFGKLTAKKLRRLPEHERDLMMLQINQMLHNKIYSLNVPKESKTTQTSPLTSQFQTKKLYRVNAIPNLNVSPSKTDSVPTPPAPEPVPEGGSVKKGRKGSGYTKACKLSPALAELMGESELPRHEVVKRVWAIIKEKQLFDPKNRQYAICDKALFKVIGEETFHTFSMMKYLKNHFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFU1</accession>
    <name>A0A835GFU1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF9">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033062519" evidence="1">
        <location>
            <begin position="41"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="281" mass="31112" checksum="936A1BA3A34BF347" modified="2021-09-29" version="1">MIDERNQWRSVRLRSPYCVPLKGLQMKLVLVLMLCALAAAAPKSHKPVPATQVADTLESRNLLVNALVRQLIAYVRYVINNGSSIFNIPPLDPLDLENYHLDVPAGLVNLDLELSKILVTGLGRFVVHKSNLNLSTLTFDLDISVPVIEATAEEYDLLGDLFTAIPLYGKGKALFQVENFRFQAKLYLKQSDDEKSVLIDRIENPSFQVPNFKSVLTGVIGGGEIDGIVNSVIEEVVIDYVNRFQGAIGKTAASLVISGLNPLLEQLDTWRYIAVLIPRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG40</accession>
    <name>A0A835GG40_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytoplasmic dynein intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG40"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="78878" checksum="AFBA4239AA6B2B89" modified="2021-09-29" version="1">MTFVYIMFNYQSFNLYVFGPETAMSSMSDRKAELERKKAKLQALREEKDRRRREKEQKDAEEALQRASATSSLDSRRDLDEMLSSLGVAPVKDVLSSLSSMTSLTPPQTASPDASLPHTDKSSLPAHGGPKKAPALQVVSVQSTDIPPKENVTYAKQTQTTASGVSELRDAHATDYYDEYNLNPGLEWEDEFTVLTFDGDGARQGDEEEAAFHGKLPPGILPHGLPTVKEVQPAVTVEPQEKKDEEKEKKVRELSADEKQTIMLSAEFQRFMSKAGRVIERALAESVDIYTDYTGGGDSENALDDKSVARLSLVRTFWDERWSRGRCVTCADWSAVHPELLLASYHNSDDAPHDPDGVCLVWNTKFKKSTPEDIFHCQSPVMSATFARFHPNLILGGTYSGQIVLWDNRVQKRYAHTTHATVFTRTHCMYIIFYPYLHPVYCLSVVGSQNAHNLISVSTDGRMCSWSLDMLSQPQETLDLQHRQSKAVAVTSMGFPHGDVNNFVLGSEDGNIYTGCLYGQRAGVTEMVEGHAGPITGVSCHAAAGSVDLSHLYLTCSMDWSVKLWTQKENKALYSFEDSGDYVVDVRWSPTHPALFAAADASGRIDLWNLNRDTEVPVASIQAEGGVAFNRVSWTPSGTHITAGDDAGKIWVYEVAEHVAQPRHDEWTKFVYTLQELRNNQADEETDRLSLAASGPSSLTSLTSLASNPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG52</accession>
    <name>A0A835GG52_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG52"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000009">
        <property type="entry name" value="cytoplasmic polyadenylation element-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="200"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="349" mass="38268" checksum="3ACAFFBFA6413C39" modified="2021-09-29" version="1">MSVHTIPLVTPFIRGPRFPYRKSKSPFFPGVEEAAVAGGAAGAGSPSVPDQAQDVVSRLSAAGLSMCVSALGSPARSSPVSAGSEHGERFSRKVFVGGLPPDIDEDEITSSFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQDESSVAALMEACITDDDKLYLCVSSPTIRDKPVQIRPWRLADADFVLDASMPLDPRKTVFVGGVPRPLKAVELAMIMDRFYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECAGARCGSKFAPFFCANVTCLQYYCEHCWATIHSRPGREFHKPLVKEGADRPRAVPFRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGE1</accession>
    <name>A0A835GGE1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGE1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="25757" checksum="39E4D00B16BCBA15" modified="2021-09-29" version="1">MSISLLSTIRRTVVNSSFPKIMASRQSSDMPKFREALRSAKEIVVLSGAGISAESGIPTFRGAGGLWRTYEAASLATPGAFRSNPSLVWEFYHYRREVAAKAQPNAGLAGRGAPDLNVRGSDIPISALPHCQKPECGGLLRPHIVWFGENLEIAVLEKAKTAMSTCDVCLVVGTSSVVYPAAMFAPEAAARGAIVAEFNLEPTPATSEFPLLLPGTLWHYIARGFIRIKKKYTVHKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHU0</accession>
    <name>A0A835GHU0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_003976</name>
        <name evidence="9" type="ORF">HW555_004747</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9630685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="295" mass="30917" checksum="AC88D4EBDD175027" modified="2021-09-29" version="1">MPPKKQPEKSGSSGSKPAEKKPATAKTPAAAPKAASSSGAAAAPKPASAKTPAPAPKAAAPKAAPAAKPAAAKPASAAAKPAAAKPAEKKPASAPSAKPGSAKAAALKAKSSAKPSVKKAAAASRPKPKPAAAKLKIAPKPKKTGIKGQKKQVVKPVAKALKAQRKVVKGEHGKRVRKIRTSVHFRRPKTFEPPRHPKYPRKSLPKRNRMDAYNIIKYPLTSEAAMKKIEDNNTLVFIVHTSSNKHHIKAAVKKLYDISVAKVNTLIRPDGKKKAYVRLAREHDALDVANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI69</accession>
    <name>A0A835GI69_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI69"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049041">
        <property type="entry name" value="RalBP1-like_Ral-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20924">
        <property type="entry name" value="RLIP76_Ral-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="89"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9416306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="566" mass="64644" checksum="5F9C8AC3B39DD385" modified="2021-09-29" version="1">MDFESPDVEKDFPGLYASESGRKSNESDFSDGADHEKPSKKDLLGRRKEKKEKKDRGYAALEGESSPEEDTDTKSVHFINFMALPIFGVPLAQSVERSRCHDDTGLPLVVRDSIDYLQAHGLKSNQIYRTEPDKIKLQQLKKLFTDRGPTFPYHWDVPVACAMLKTFISELPDSILTQELHGQFEQATAIAEPQREATMLALIAKLPPHNYSLLGWLMRHFECVVANEQANHANIQTIMTAMGPALNMSLNLLTYLVSKAEKLFPDVQLTKYVPPLASIPPDFPETAPELNLELRKQESLLNQIHAEMHAGFITPARDQQLWEAQRIVTQLKRKLRSVQKSVEPQNSLQPQHASLDERHEHKTEDEPVRRNSQPSQPSAPLQMPVEAQVTPQEPPEVKTPNEPFLDPKESPSQEPIFEAEFEDNFEFKPEIPIKETPEQELPPAEPIKEKPKLTEKELKVLRLELENAEYLQLKSLLQAKINSEQFEIVKLRSHVALKNKAEGAQTTKETKENNIQDEQELRQRLIKENALLEQKRINLINQIFQERVACIQLKIELAMKEILSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIH0</accession>
    <name>A0A835GIH0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIH0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="5">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="300" mass="33272" checksum="EA0E1DCB52AC47F7" modified="2021-09-29" version="1">MSRKQDRYTSRPRNLSSHYSSSPSMLGTMLGSQYSPYSNNYSNYSSSAYRNYNPYSAGLGRPSSNLGIYGGTSSGYGGVYLSGATLGSLNLMTPVLKKLDKRLLASKKDFKPKPVPLAKVQEPTDVPVDAPVVLPAPEVDDVPPVRPQRKNRANKAGNLDKERSRSLSSLETSGALGSRSLSLNSLASDGYCSGSERTEESEDKDYKALYEASQSEVRRLRALLATSEQQLREARATITRLTQVNQNSLSEIEKREKRAMERKLSEMEEELKYQQTLQAENQRLKDENGALIRVISKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIH3</accession>
    <name>A0A835GIH3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polypeptide N-acetylgalactosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="187"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="297"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="376"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="448"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="8">
        <location>
            <begin position="692"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1254"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1268"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1319" mass="149194" checksum="C57FEE63E523232A" modified="2021-09-29" version="1">MVYFPVRKCYQAAKLVLLVVLVVTILALFEQWRGGKRNAQAEYSDPMEAEYERQILEDEARIIPGLGEGGAAAHLLGEEKKLGEESEKKLAINVYLSDRIPYNRTLKDYRNPACKRVVYDAELPSASVILIFHNEPYSVVVRTIWSVVNSARRSQPWYKHANFMDRQTGRVTTVGYPGQDPNSEFVYLKEIILVDDNSTLPELKGKLSHYVRTRLPPDLIRILRLPDRIGLTQARMAGSRAARGDVLVFLDSHCEAVQDWLRPLLHRIKEDRRHVVTPLIDVIEKDDLVYEAGDPTETGLIRARLAGSKVATGDVLVFLDSHTETVIDWLRPLLQRVKDKRDAVVVPAIDVISQDNFLFAESLESDEVDTDVVCGRSVGLTRARLAGARYAVGDVLVFLDSHCETQPDWLRPLLQTMKDDPHAVVVPIIDVIEANNFFYSVLDTKTFQGLMLARLKGARAARGDVLVFLDSHCEAGPDWLRPLLQRIQHKRDSVLTPIIDVIHQTTFEFEAPDTFQVGGFSFMGHFTWTDVPEREKKRRGSDIAPTWSPTMAGGLFAISRTYFWELGAYDEQMGGWGGENLEMSFRIWQCGGTLETIPCSRVGHVFRSFHPYGMPSHMDTHGINTARMAEVWMDEYAELFYLHRPDLRNNPKIGDVTHRKVLREKLKCKSFQWYLDNIYKEKFVPVRDVYGYGRFNNEASRLCLDTLQREGEAAPLGCYPCHPDLQATQYFSFSLAGELRDEFNCAVVQTDRQSLGPGTSRAVVMSACHGAGREQRWRRLSSGQLQHVRTALCLRAPPDIGDVQADLYGLYCMYRRISRSLLSYSEPRSNLLEDAQPGDSANTTVRRHGHKGKHRKRHGRKRRGKKRTKNKFILKIMRTLMNGTEEHLEMDIHCKHRQLYPNNTFVRDLVTILNDKNVKVINNGRVFERNKVTEVQQQAQKVLNKLDIEPSPPSPSSSPLRHQPGSHGGNLAQMREGQQVKLRLKKNKSHPAVQSVITREPANAALSHAGGPRGHHGGHREGDNKIIIEDFVEVKRLTVSPPPKEGMEGQSQHTHKRKRKKNRGASRSRPTASTTPGATSTPPPPPPTAMVLPEPESLRERLADTRSEEHSSSDKADNSAETPLLSDSMDRSDGREDWPVGESRYRSKPQRRSNGDSQSAERPAPSQPRLEPRLEPRLEPHLEPHLEPRPPHPHTHHEPDIQYTRDDPLTAFQPPGGGEQGGAAPVKVVMRSNLTFNLGDDFFAWKKRTTSSASSPYHRATARRRRAPLAASTPPRPPTAAATDYRDFLTTHYTATFLVARTTCYLILLTMIECHPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIP0</accession>
    <name>A0A835GIP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_017967</name>
        <name evidence="3" type="ORF">HW555_005352</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9627992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIP0"/>
    <dbReference type="OrthoDB" id="6127080at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032545724" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9627992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="163" mass="18917" checksum="87ADF55CD58C61B1" modified="2021-09-29" version="1">MLLMKANFYLCLLLLYSFWICSTEARRGRTRSRTKSKVQIGLPITGKYRDPESDQYYNNNDGAKILLASHFDLEYVLGHKIAFLCIAKGSPRPHITWFKDGVEIFAHHYLHIHEWPIGEDRVKSKIEIDPATQMDAGVYECTADNMYSIDRRSFKTDFSIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ27</accession>
    <name>A0A835GJ27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="25394" checksum="1DFA06E295B03A2C" modified="2021-09-29" version="1">MLLASSDLSEIFGIVIIAAACVDMGMIKGFAGMEPTGHETDALLIAIGVLIIIIAAFGCFGAWKESPKLLYIFVGCLIIIILLELSVGIAAAALRPQIESTLKSQLRASFIKNKSTKEEDSTYREFWDRVQSSLECCGITGPDNYGASEPRINPSFSCCPNDGTDHSAEIKRSNCLSDGKYYKEGCEDKVLGTIHSAGMTVIVCGILFCFLEVAGIVLALWLAHSIKTQGKSRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJK4</accession>
    <name>A0A835GJK4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RUN and FYVE domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJK4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="10">
        <location>
            <begin position="201"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="810"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="816"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="98677" checksum="D9BF097EB8685E32" modified="2021-09-29" version="1">MASSKEREVDVSPATSTTSVKSQFFDRSPSVSSSREDKWPELLLSRPDKSYYYSSKNPDLKLLLQGSFMWWVLHGKPTTVYLDGQLSVSLSRDGIPSAIQHQGDGNPDGDMAGAQDTIYLCNFRVSVDGEWLCLKELHDMEMQDSFHRPSAQGTIKSPDDPMNTLMARDPVVIERSNLVNISKLIVKELIEQSLRYGRMLDSDHLPLHHFFIVLEHVMRHGLKPKKGLLGPKKELWDILQMVEKYSPEAADITASVRDLPTVKTAMGRARAWLRLALMQKRLADYLRILLEHREDTLEEYFEPHALMLNEEAVIITGLLVGLNVVDCNLCVKEEDLDSQQGVIDFSLYLRGSNSSNDLAGNGNGDSEPKQRHINTMLDQKNYIEELNRHLNATVANLQAKVESLTTTNALMKEDLAISKNTMIQLVEENNQLKHALGQDITKDTRMKVTELQSDEEEKRSVKSVASDKSKNDSEASKNLEEERKKYLELQRELDLQISLKAEMEVAMKLLEKDIHDKQDTIISLRRQLDDIKLINLEMYKKLQECEMELTQKGEMVSRLQGKAEQIGKILHNLEKYNHFLGSDNDLVKALRSPTTNENNLGEKLEKLKAQSNAQKGTKSKDEGPPHKKLNLQEIPPFRKNTPRDKTECESSLKHKTELIAKLEAKTESMGSTIHQLDEKLQEDKLARKNLEDSARSLGQKAAAAETRAVAAEGDLRIEREWRVSLQESMMRDRDKISMLTQEVESLKSIGQKYLTLQEEQHLLKTQYVEAQKTLEEVGATLSENKLQLAELLEKEAQAQNVEEPPTWTHDKDATACTACAKEFSIARRKHHCRRCGHIFCASCSDKTVALAGNTKPVRVCDACYAEVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJL9</accession>
    <name>A0A835GJL9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJL9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000157">
        <property type="entry name" value="Inorganic phosphate cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="865"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="87"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119815" checksum="2846B1897F2ECFB6" modified="2021-09-29" version="1">MAKVNDVCVIKAIESYRWTCKLCQQSDWLVGLSPRCYQILANVDDIETATQTTIKNFRSASATTPISRLLKHAVPARFNLWVMLFTSCWVVYMLRVNMSLNLIAMVPQTHSNSSATRSQCGPKNDVFSNETLQRVDGVDVHAAHVKALILGSYFWCYPVTSLIGGMAAERWGPRYVVLVSSLASAVLTALSPFAANLSYIALVVIRFFLGCAGGFIYPALHALVARWAPPAEKGKFVSAMMGGTLGTVLTWSLTGPLMEKFGWASAFYVPAALTLVWCFFWWYLVADTPSEHPRITEAEKNYILDALGDKVKKSKGLPPFKSIVTSLPFLAMTILHYGNLWGLYFIMTVGPKFVSSVLGFELSAAGVISALPYLARLFLATIFGVVGDFILARKLMSTTAIRKFFCLFSHILPGVLLVLLVYAGCSTALSVSLITMSMGFNGAATLTNLQNHQDLAPNYAGTLYGIANCVGSTAGFFTPMITAYFTSSGNSFESWRPVFFVGASVYIISALFFIFFGTGNIQPWNFAPEDKGKDDKSNGDLKEMNGSPPKNSETKEIKETTLNVSNERDWEYNFHLSSDRRHHIDVGVMIFLGYFLVYVVRNNLSVHIVDMAQVMQRDDDLLDGASIALRRTMKRTGMMDLINWDDTKVGKLFSAYHIGYCICFPIFHNFGDKLGPTWVVGIAGLLSGVLSCLTPAAAYYHFWVLFLVRFIKGFCAGAMQPSMVQVLRHWVPPIERNHFMWAYCGITTGTFSTFLMCAAIHYYSRWPIGFFVSGGVQIIWSITWVLIVTDYPKQHPYISNDEMIYLTNTIGDIFTIKKTNSQAPWNLIVRSSPFWMLCILNFGYSWMIISLCLFGPLYYSKVSKFSIYSASAITALPFFLRLVLGTILIQAFHKYKNRPEIREINHIRKYFILVSHVIPGLLLCVAWMLPIIPGPLLLTIAVALTAAGMDLTLDLCYELSPMFVNSLNTVIKIIGNTSGIIVSLCVGQVTYRFGNFPIVWKHIWCFHALILLLSGLIFLIWGETEIQPWNHQTRRVLRRKYVINPLPSIMSNIAEVEEGSVRSSMIKMPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK65</accession>
    <name>A0A835GK65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_012913</name>
        <name evidence="13" type="ORF">HW555_005935</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000345">
        <property type="protein sequence ID" value="KAH9639303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK65"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9416805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9639303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="108" mass="11802" checksum="43A2615A3E4D3A10" modified="2021-09-29" version="1">MGIPAGNAENGKKIFVQRCAQCHTVEAGGKHKVGPNLHGFWGRKTGQAAGFSYSDANKSKGISWGEDTLFEYLENPKKYIPGTKMVFAGLKKPNERADLIAYLKEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKU9</accession>
    <name>A0A835GKU9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKU9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21424" checksum="0168C6FA70730353" modified="2021-09-29" version="1">MKSSQLTINGQHYNNAHFTIGLSLAISSSVFIGASFIIKKVALRKLQASGNVRASAGGFAYLKQWLWWLGFITMGVGEAANLLAYAFAPAALVTPLGALSVLVAAVLSSRFLKEKLNFIGKIGCFLCIIGSVIFVIHSPKSEEITTFSELVEKLLDYLFLSYVGTIFLMGLIIKLAFIPRFGNKCDGIFTTMLTQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLT4</accession>
    <name>A0A835GLT4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="21016" checksum="827DA6404C97C4F8" modified="2021-09-29" version="1">MAVVIETTLGDITVDLYLDQRPVTCLNFLKLCKMKYYNYNLFHTIRSGFIAQTGDPTGEGSGGQSIFGLLEGPDKRFFSGEKMPKIRHTGAGLLSMVGTGDMMIGSQFFFTLAPDLDSLDGIHCVIGEVTEGHDVLRKLNDVICDEGYRPYRDVRITHTVVLEDPFNDPPWTEGSFKITIPKCRASEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMM8</accession>
    <name>A0A835GMM8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053347">
        <property type="entry name" value="Axonemal_MT_stabilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404:SF1">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="360" mass="40683" checksum="7C050C1E27D203FB" modified="2021-09-29" version="1">MAQSKPQQPLALNDLLIQNVNTWGNVQFNIPLRLSNTETRTSTSIGLRQIPAISHSLDCKITTPLPKRATGRDMVVEKESYKTTTGEYCVKPNPNKAMERSDCAINCKRVCFMTGVEKRLQAKNIIQPTMISEMKDNFRGLTKSPLAPPDTDVKAPDPEFIFDAVAAGRNETPVIFDDAKGGYRKLLDPYVSTYRTYHRPFTPDDQYGIGAKDHITFYSESSTPKVKGFGPRHKEIWMPLTAKVHRGVYDRIHVKKEYKEVSASHNPVKNLKGAFISETMKKYKTPFAISSLASWDHGEVFDLAPFPPNPYQTNIAPFMYCSDYCHIAQGTPPYTVIDQFAHNLPPHKKCVKRFIVSSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN12</accession>
    <name>A0A835GN12_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vestigial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN12"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF15">
        <property type="entry name" value="PROTEIN VESTIGIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31183" checksum="B085FD3B0FD4F9FD" modified="2021-09-29" version="1">MAVSCPEVMYGAYYPYLYGRGAARSFHHAPHFQYDRFNVQSGAGNAGSEAYSGGAAALSSGSASSGAQSPGSPPHAHLAHHAARLRTKEEDLSAHGRASADGTVHSYTQILDAAMIPLRQHVRCAVCAGGGSSDANCVVFTHYSGDVAAVVDEHFARALSLDKPKESVPMVSRNLPASFFNAAAAAGVAGVPAGGACAGVDIYDYDPWHQHYTGTTRPRRTTTWRRRPATAACCWAAAACTRSTSRWTGPPPRSTTPRTTSTPPPARPTPTPPCPVPHAFTLSLMRSDSFHVAAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN31</accession>
    <name>A0A835GN31_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_003351</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN31"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="18">
        <location>
            <begin position="73"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9420429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="426" mass="48796" checksum="FAC8071B05358DB2" modified="2021-09-29" version="1">MIYLVRNQFQISLFFANQNQISRLLRISSLFSLKVTNYFYFVSVSATLPPQRPWIPLTRPNRTRPTCIFTVMCYNVLCDKYATRQMYGYCPSWALEWDYRKKGILDEIRHYSADIISLQAMETDQFYNFFLPELKQDGYDGIFSPKSRAKTMGESERKYVDGCAIFFRSAKFALVKEHLIEFNQLAMANSEGSDNMLNRVMPKDNIGLAALIKTKEAAWENGLPTDSSMLGQPILVCTAHIHWDPEFCDVKLIQTMMLSNELRTILDESARSLRLAGQRDNVQLLLCGDFNSLPDSGVVEFLSSGRVSSEHRDFKELGYAGSLRRMPGSEHEFTHNFKLASAYSEDIMPYTNYTFDFKGIIDYIFYSKQSMTPLGLLGPLSQDWFREHKVVGCPHPHIPSDHFPLLVELEMCPTASANSNGLIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN77</accession>
    <name>A0A835GN77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial nucleoid factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitochondrial protein M19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037698">
        <property type="entry name" value="UQCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34260">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34260:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="114" mass="13375" checksum="10AEF447997DB401" modified="2021-09-29" version="1">MTTQYKKFTRLIAKWPVDTTKGERDLGKFIRDKVKAAFESSERQNLDSELCNRQYNSLNKIADNHYRNKYKRTHNSTATGLSTEECNVILSNEVLEYLKEENKGFFAKIFGRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNL8</accession>
    <name>A0A835GNL8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibroin heavy chain-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNL8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032532887" description="Fibroin heavy chain-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="25104" checksum="429BC111D5BE5C9A" modified="2021-09-29" version="1">MAAKFIVLATILAASNALPVWYNGIPAVVMRIGRSPSISYGFGSGFSSNIGGISHSTGIGASFQSGEGEAYGAGIGSSNGGYARGVGIANAGNSHPVQYHHAYQAPQPAYESAVASAQNFGGYGNAVSSAQSVGGNNFGSAVSSAQSGGLARFNSAVSSAQNVHGYGSAVSSANSGYGSALSSAHNSGFGSSVSSAQTRGHGYGSAVSAAENIGGYGASTAQVARQSPGGIQHSGATSINAPGLQAAHSHAINSGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNQ2</accession>
    <name>A0A835GNQ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNQ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23735" checksum="60B577FBA417F9EE" modified="2021-09-29" version="1">MNVFHRFEMSNETQIVQWLDEVSDEEQDVAGSDSEDETVNDAAIDSAHDSESEIEESEDIQNISEPSEDKIKARFGRDRDALPSDDTEMNAFLGLLIMAGVLRASHLNFIDLWAQDGSGLAAALVTDHQKRRIQLRAVPTTTKKRLREVHDVDETVQQSTAKRGRCSSCPRKNDKKLTSKCFKCHKFICQQHSRVYCVGCRTEESADETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP37</accession>
    <name>A0A835GP37_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP37"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032653666" evidence="2">
        <location>
            <begin position="26"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="548" mass="62628" checksum="326FDFC74D27FE16" modified="2021-09-29" version="1">MHARMLDMFSVLFLIVSLSAFQANSETIESAIYKYYKSDGVQQLRKDWELYRKSMEHAIATNLKETMGLVGVNVYMKNPILTLAKGYCHDDNQIRLIVKNLKLQEIPRFWMPEVQFSLASNVLKLQTGLSKVIVNADYTLMRNKTRIIYDKRQQDFANWSPFLYQQVQNNGKVALVMDDCILSGFFITTLSGNSVNLGYNHFKLIKCVINVEIYHTGDESPPVIAKYQPQRDDEWSLGLKDLVLKPIVEDLHGKLQAAMYSFVNTSSLFGDKLQGYIDEQRKIFAETATFLTYIHRNLNKITIDRKKTLIPLNDHRVFWDDGKSEFALSAKKSVGQTVIFKEMVLFGLDTMYAAHSGGPYKMDTIMIAEEMRFSTLQVKGFFELVKGMKLDRFSFAAVINDLAVDLQMDVRLDENKNRKMSLLNGCSYKTLRVTGYREMILTLPSYKHESIESLIYGHLLSELPIAIRIHLKAILREALRPTTTTTTPAPRSMEKENQSGAMPPAECSEDDDFKEENTKQIVKFKNASQEAVQRNGTGTPTAKKDRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP74</accession>
    <name>A0A835GP74_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="71866" checksum="248C473CEC801C6B" modified="2021-09-29" version="1">MSKKMKKMKDFFFYNLIILSVVNGDIKLILPEDKANETMDFNSITDCIIKITQTELYFRPTVAILDQGNNASENIFDNELIEKLTKYNIPQVIIQDVFSEENYDLHLIGLTVAFFDKCADIKNFDFKSIEKEMRFLIIICDSDDYSDSCVDKLEEIGDLVSKHAITFIIQDFVTGRNKMYTIFPKIDETTCKEVVERPSHINTCFNGTVENEEIFPVKNPNNLNRFRIGMATLFPFSLIPNKELLKNYDNVTEIKGFDYEILKIVAEYFNATLETHYIYRKEENPYKDLEFTDFIKNGSLDVCAGGLYRIYKDAVEYSGIYVRQAVFWVYYAERAERSWQNLVSKLDDVYYFIIFYITYSIIWCLVSSFDGQAVSLITTLIHGWGALVGATSLQEPRTKKQKLLNLLYLIMSVYSSVYVSIQFYSFLTVRGPPEIFKTNAEVMGSGRTAYLKNSSKYFITDERYTEYAQRSADCVSFYNCAEKTLMYNGLTLLLQANFYIFQATSAVNGEARVLRATENMLTVYNEMLIRKDSPLVEKFQKVMKRLFEAGITGRLFTEAIGISVVAKAESANSIMIASSYSCQAGCSITLMQFAGIFYAWIFGCVISCLVFGIELFLRRAKVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPE5</accession>
    <name>A0A835GPE5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc phosphodiesterase ELAC protein 2</fullName>
            <ecNumber evidence="6">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">ElaC homolog protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ribonuclease Z 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">tRNA 3 endonuclease 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">tRNase Z 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HW555_002997</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">BAW_Kor-Di-RS1</strain>
            <tissue evidence="26">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homodimer. Interacts with PTCD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000014">
        <property type="entry name" value="Zinc phosphodiesterase ELAC protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="25">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="884"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1021"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1251"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1293"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="939"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1047"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1258"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1335"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF9421014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1447" mass="161643" checksum="44C5EE31E7E0E733" modified="2021-09-29" version="1">MYGISVLFSSRVVSKRSLRPYSSDSTKKLLEFLADMPKATSGRIAEAQRQRQHISKKSEKYGPSTVYLQVIGSGARGAPNTLYLFTDQKRYLFNCGECTQRLAHEHKVKLSRLDHIFITSKTWRNIGGLPGLSLTLQDVGVPNITLHGPEGLDELYTATKRFVIMKDMNVTMAKCTPSEDFEDNVMRVEYILLGPNDNILQGKEKPAAKKPRLDSNSDKEYEEFIHDDTDYYRSDIRNLEANSANPQKAKNLREKVKPKPLHTEKENAAKKKTDKVLHDLQKKSNCSVAYICTLKKRLGTLDLAKCVELGVKPGPMLGQLKSGQDVVLPDGSLVMSKDVKTPDDPGPVFIVLDVPDVTYLKENEFSAHFDNDTNPPENIPALIVHFTPPHVFHHPTYRAFMAKFGPCTRHLVLNAQNSCLGSEAVHRTQHKLHLLDPDIFPLLRDVSVPAVWDAHPPVPKTNSPIRLKGLEELKNKIALAQFQNIINLEGSAKGDGHQPAVEECDSVSKLELMAGRTLTMYHLRPKKQLDRTAEPKLHIQSYIQETMDVDGFVGSLEQFRHLVDSMRFTRCDSKEYPKVVFLGTGSCIPSKTRNTSAIVLQIDENKSILLDCGEGTFGQLVRFYGPKKVNSFLRTLKAIYISHLHADHHIGLIGVIQARREAIQELGPLSDDTPPPPPLYLLAPGQIITWLTWYDHQFEKIKSEFTLIPNQNLLYDHEQNSEVTSAVLAAMGVQNIKTCFVAHCPNAFGVAVDLNDGYKVTYSGDTLPCEELVKIGENSTLLIHEATMEDELADEARMKMHSTTTQAIDIGRQMNARYTVLTHFSQRYARLPRLNAHILNDNNSVGIAFDNMQITMSDLDLLPHMYAPLQLMFAEHCVEMELKAAQRQRQRDRQTSPAPISGTNTPKRARSPSQGNDLTKRSCNHGNGQTEKQLPGLDSSKSTHTANKMSHVQNRKLSTDSTSNSENNSKIDGSSSRPQSLGCGRSVTSSAATVSIPPPPIRYRESNASRLRQEMKGMTVWGIVKTPRSRSNSASTSGSHEVNSPKAKQDEARTSSRQPSAERPKEKDGVEKDILTPRSQSENSNDTLAAVKACNVPPTENVIDTRSKTLSSVGHTHLPTAEAESNIVSKSRNNHRANVHSIVGHMKPTTDGGYGKPLVTPINKKLIRRDEHWFPDLTAKSSLTGNKLRASNTNPNVFPDTKTPTIRSNVASRLRTFPLTRPSASSLPRTKSPQRQYITMSKPQGILTVQTKQNYGQRDMKDPRTQDKRNTKQWKPGTAAKQTFLFSEINSRACATPPRSATKAQSPTKILSPTRASSPAPKRIPTSEIGHRACSSTPRSPTRSPTPTRLLSSTRASSPAPKRMLPNEPIKKQTMPNNDAACEKEQIRHTLPVRGQKIKENKPSERSFNEELRKQQLNEAKKKFQSKRFFIDSKYDKIEGLNWISWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQI8</accession>
    <name>A0A835GQI8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQI8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="144" mass="15612" checksum="4A850CFD68F0C228" modified="2021-09-29" version="1">MNQAASLATGSRAKAQAGPMKAITSSLKCMSAANPGAIAPEHDGKQDPRGYISLQASITGIDVALFHTNKAIQTVATPYRRNWKENSMHQVLHGFPNPVVDREGFNTWLITVSDFVNKYHQTAFAANSEPTINIISTVDSSFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRF0</accession>
    <name>A0A835GRF0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="47067" checksum="05AE57B29278E0E5" modified="2021-09-29" version="1">MNKTLRRGRGPHRDSPPRTNAYRNKGQSGVENIPHSSFRPRCKEKNVASRCCYVTPDQKDFGQSYGIDRRSIESRDKRLHRDMFTGKNSFQNDHNQTLKNNQQCFDPIKVETIAPSREKIKKVLYTNDSKVESRPHYTQRATSPVFVEAPDGSQWQNVDNTDNLDTIIMNEDPPAVYERLKNHIYISEVPQIKIIAEKFSKYKKNNIELRRLDEKVVCVEYDIYDPASKEDLKPIQRMRAFFSIKPVVGDGCGNHESKLPTLPSNIKQQFNILDEDLKKLTDKEIEIIDGKIEENRSYLDDLRRILKRKQVIRVKRNRTALDLESLYEMAKRDMSSLGCRYSGANLLSKEELQEVKDLILHRCASSVHGIRRKSLKRKEKGSAKDFGVISQSIVAELWRDDAKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS63</accession>
    <name>A0A835GS63_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_000652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS63"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032602886" description="SSD domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="585"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9424259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1241" mass="138499" checksum="C11D16490B799A67" modified="2021-09-29" version="1">MQFSITFLCFLTLWCSINARCLMRGECDGNDGKVKPCYNDTEPVSIIEDVAEEDVESVLTTFERICPTFLIDDEGNRLPDDEIYTCCSAEQVFSMAESLTLAESILGRCPTCFRNFARQICEMNCAADQSRFVEVVTEVGADDRVYVNGINYTLHEDFMLGAHSSCSNVIVPQTGFLAINMMCGSAVNCTAEAWFGFTGDTEANPITPVEVNFHMTSDKEISMHAEALPCTETFEGDLPCSCMDCRSTCPDSTPYVPDICSVFTLSCVGFSVGLVFFAVTVLIFIILTCVQRKKQNQETSAKKSASGPNKMTKMFQKLFAKIGGMSANNPVLIIMITSWVAFGMVFGVMNLNLTSNPIELWSAPDSRSRQELNFFNERFGPFYRTAQVFLTFHTGPFKRSNDDGEQWYGSAFRLESIQELVKLENKIKNINSEGEGVTLADVCYAPLLERGAPKDINLCVSMSATSYLSNTIAINNVTYLNEIQACINNHYGFGCLASWGGGADPDLAFGGFEPGNVLSANTLLINFPISNFLLNEDLEPVLEWEEKFLEVLHEYKSSVDPEFVSVAYAAERSVEDEIKRVSVAEATPIAISYILMFIYVTISLGNVRSCKTRLIDSKVMVALGSILTVVIAIVCAMGIMGYFQITLTLLAINVIPFFILSIGIDNVFLMVNTLHDIQSNLKSFDDYKEDLSFEKRRRYVFEKMMGSVGPSMFVSSVTQITCFGIGSLANFPAVVTFAIFATFSLAFLFIFQITTIVALLSLDYKRACQNRFDIFCCIQKKILDDENPLQSETPYTGVTQRLMVPYSKFILDWRVKIVVAVLFMALVSINVMFIPELEVGLDQQMALPSDSYVYHYLQAIANYIRMGPPVYFVVKGGLNYTDPDHQNVICGGQLCHEDSLNMQIFLATLNSDITYISKPSNSWLDDFTDWSGLYGVCCQYNTTTQGFCPSGLNSDDCKHCSIPRSDYANGRLRPDKEAFERYIPFFLQDPPTEICNKAGLASYSASVNYVLDSEGRATIHDTNFMAYHSPLSTSKDYITAVENGYRVSDEIMAAIKKHTGLDIEVFPYSIFYVFYEQYLTMWADTFVAIGYCLLGALVFNLLASGFNILTTFAVMFNVILVIVNMMGIMFIWNIPLNAVSCVNLIVSIGIAVEFCSHIAYAYSTSQLQGHEKIAEAIQKVGATIITGITFTNIPIIVLAFSYTEIIEVFFFRMFFSLVILGFFHGMVFFPVFLSYLDGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSM0</accession>
    <name>A0A835GSM0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9423989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSM0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000096">
        <property type="entry name" value="Carboxypeptidase vitellogenic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033109047" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9423989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="470" mass="53370" checksum="EC2666FD99329870" modified="2021-09-29" version="1">MCDFNGFRSILLAALCAFSVVNATFFPDLYPRLKLDARATKDAGVPLFITPYLKTGSISLAQNLSRVSITDTIGFRSHAGFFTIDEKYNSNLYLWYFPPFSKQEGAPIIVWLQGGPGGSSLFGLFQELGPLIAKKEGFALRKYHWALNYHVIFIDNPVGTGFSFTDNEKAYCTNEDCIAEGLYTTLKQFYQLFPNLKKNELYLAGESYAGKYLPSFGLKIHHENAKGKEKVNLKGIAMGNAYCDPINQLDYGNYLYQLGLIDDNALKLFLKYQGEIANQIKQENWEQADVLMDRLMDGDMTNFSYFKYYTGFDYYYNYLQSSAADDMSIFISLLQNDKVRHAVHVGGLAFNDGLKVQLNLILDMLKSVAPAISELLSHYRIMFYNGQLDIVVAYPLTENFLRNLQFSSAAEYKNAKRMIWKVDDDIAGYVKTAGNLTEVLVRNAGHMVPRDQPKWALNLITRFIKNDFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT52</accession>
    <name>A0A835GT52_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT52"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032382199" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="49"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="25796" checksum="4FAF9221DDB8BF0E" modified="2021-09-29" version="1">MKQILSLLFTVCTFSDVLSAVNLQEEEVGNGRYSIEGKVFPPEEQDLLPWQVDTRVHVNGGEYIGFIRDDGSFVIHNVPSGSYVVEILHPDYMYEPVRVEINSKGKFRARKVNYIQTSQVIQVPYPLRLKALTRYRYFQVREQWRLTDFLFNPMVIMMVLPLLFIMILPKMMNDPETKEDLKQISNLAKMSDMPEMSEMFTSLFSGGATAKASAAKAKQVKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ53</accession>
    <name>A0A835KZ53_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000540">
        <property type="protein sequence ID" value="KAF9406850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ53"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="64" mass="7098" checksum="91EEC946425888CC" modified="2021-09-29" version="1">MYHQTTEEISIPKAGLDSTSLVMAGDVAALVRIVSETLTYWRSDITLTNPGWPTTDKLTRDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ78</accession>
    <name>A0A835KZ78_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000306">
        <property type="protein sequence ID" value="KAF9409626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="736" mass="85492" checksum="09D3CC40D1A0EA30" modified="2021-09-29" version="1" fragment="single">VSNVVCGKKSRKNKRPKDQEDYTTIQPNVVAYSTFGVNDVVSYDGFIPTSPDYATFLSGVNQESTTRLYAPAFPSSMDTTGFGGNYGAQAFEGQSFGVNEVNMGQPGGMLQYSSNSMNFFNNPNFGTTAEQNNNNDSEGASGHNHNAEETDSPVYGTKINSRQKYRTNNTSFNSYSNGYSNLSDNKYLHFPEPEQTNENKPAFSESGGSYQNTNNFVHNYEPQENEDSGKRPSLLNFPKVVDFTKLNYPTELDSSKFLSEFNQPQNEPNSMKNTQIENTFAHNFNSNTNKNTNNNQFMDSTPKLVDHYNMKNTEEPNDKHKNNAASNKPLEQKKKIKNKPWSSGNYSNDFASWKDSSLKSYGYSTNYSNMNFKYDVSEPKKPFNPDELVPASSNVDLTNYQYPDSEYSNFKKMPEFNEDDEYNSVSFKEKSKPNDYLNRFKNSISTIPTTTSYWGNVYPSFKDFAKKPHYSEIGTDVVNIPKRPPKINYPKQSESKLPDWPYTHINRPRKINKPTNDWTKDLFDTRFKSEEDLLGLRTHDTSHPTYLPTFKPSNNVYDNDNEFKNLVERWRQSYLKTKLKDAPVRDYESYGSETKPMHVPIPKPYPVAVPVEKPYPVHVPYVRPVFHHTKPVHEDPENIEEEDFMRRPEIKKPTQYKKRPYGTRYRSRRPSRASYQQDRNRRRWPERRRPTHSMEHRHQSRPTEFHSPPYKHRDYEPEEDDEPSDYRAYCRRTGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZC8</accession>
    <name>A0A835KZC8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000295">
        <property type="protein sequence ID" value="KAF9409830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZC8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF44">
        <property type="entry name" value="ODORANT RECEPTOR 13A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9409830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="379" mass="43920" checksum="D3D9D5653A147ED7" modified="2021-09-29" version="1">MIEAPTMSDKEFYETLKLTRHALVISGIKISNEKMNKALEYFINHYLFYCNFIALHTVIIGEMYWVVAGIQNRFPFVELSLISPCITISILGTVKTWFLYTNKGILLNVVDRLKAIQPIVNKESLEKTDAIKCKIVTDSMKLLKFVHVSLMTVYIFVFTTFCFSPALLSSYNYLKTGEFACVYPFQVKYFFEVYKSSLWFFVYVHQVWATAIVIFNIYGCDTLFCALCVYIKMHFRLLGLQFEKAVSVSVNETRKNLGMAVERHQELIDLVNQMEVADEMRFILAFITFLVMSLSQISLVCYFADLLMISSIEISDSVYKCPWYEADQDSKNTILFVILRSHKACRLTAWKFADLNLGAFTTILSRSWSYFALLKTVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0U8</accession>
    <name>A0A835L0U8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000434">
        <property type="protein sequence ID" value="KAF9407797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="18870" checksum="D65626A7269B1FC4" modified="2021-09-29" version="1">MLQHATSSQSIVFHQLQAAPVAPVTAPSPVIPSSSASHTKYEYKYEVSDHQTGDRKSHWESRDGDKVRGVYTLYEPDGALRTVEYTADAVHGFNAVVRRNEANKHSHLSAGYKHESSTSSRDTYDEPNHGYTSERGIYPGQGNAPRRPGKTNSYNSGVDFSVVHGNSDKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1L0</accession>
    <name>A0A835L1L0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000258">
        <property type="protein sequence ID" value="KAF9410543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1L0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032647277" description="TNFR-Cys domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20805" checksum="D21BA0D0BD63BDA1" modified="2021-09-29" version="1">MLRLVCTTLLFTTILVVRAQPLSCEGDEHCFEGYFCETATNICEECLQCEDFNRQPPKLNSTECIKSLDKCGPCNEGYINIFRNSVKGKCVLPEFLEFGKGSHYRYVCLIAAAVGLAVVAMFVYVIKQTEVFRVVAYYDPVSENLPNSNTVTNESLGHLLKYLLQQQKDPNEKISKSCERVINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1T4</accession>
    <name>A0A835L1T4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferin 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1T4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="201"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="370"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50830" checksum="21A3A068E1DE55E9" modified="2021-09-29" version="1">MIKNKLYQYGNQNGRVPAHLNFGKEVYDNMVANKDIIAMINADTSEQMTYGEMAQSIADIALSLSRMGIGKGDVVCICSEKNFEFLPTVLDPLAHRVKIVRPKVVFCSQTAFKQHKPVFDEVGSVEHYILYGDQAQDGAILFKDFLTETAALEDFEPVPVNGWEDTAFIVYSSGTTGLPKGVPVTHIGFLLNAQNMTTQEVLQLAPMIITELIKSANLDRYDHSSVNYIVSSSTYIREDAVLAVKKRIPSLVSVLQLYGMSEGGSICNELACTKGYKAGSSGLPGLGFIMKVVDLETRQPLGPNLRGEICIKGPSVMKAYLGNVQPDCKDEEGFLKTGDIGYYDEDGYFFVVNRIKELIKFNDISVAPAEFEDILLQHPAVREVGVVGKPHPVHGELPVAFIVLQSGATASEAELVEHINSRVTYKMRLAGGVRFIDRLPRGAGDKLDRINLTQRLVDEDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1X0</accession>
    <name>A0A835L1X0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_008261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000155">
        <property type="protein sequence ID" value="KAF9413559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1X0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032382815" description="Peptidase S1 domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="36"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9413559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="341" mass="37983" checksum="A4A84D49D2F5A448" modified="2021-09-29" version="1">MSPQIFLFLLTIATYTDQARIITTLKYSTFRVSPKIVHGSPVSKGQVPYLVSIKEPSVNVSQAKKLWTNLCGGSIITPSKVLTAAHCFEANQFFYATNFSLLRVVAGNLHNHLIDSGRTSTSDKSQWRIMSKVVLHQNFNFPLNDIALVFVDTPFVFSETVNYVIPARAITDYPKTCIAAGFGETQHGSNTSRKLLWTDISVLSRAQCDFWWEMEMNDFICTNSQASDVGAGDSGGPLACYGTTDPTEQKGKDLLVGIVSGKNFDKTTLFTRVAAFDTWLQNEGQTSIACICEPSKIVLSFAIILSYIRLLILFIFGVGFTKYVHLCTVYRYYRIPAILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2J3</accession>
    <name>A0A835L2J3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000645">
        <property type="protein sequence ID" value="KAF9406063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2J3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033094706" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="554" mass="62768" checksum="1D34F0F606984300" modified="2021-09-29" version="1">MQWRTCVLLLCVTAALADDEWREVETAQGIVRGRKHPTEDIYTFYNIPYATAPVGVDKFKAPVDPPKFSQPYDAIDKQVVCPQAKLPISNLQLRTLVQHENCLIANVFVPNTNKKNLSVAVYVHGGGFVMGWGEMFKATQLMKTKDIIVVTFNYRLGVHGFLCLGTEDAPDQVALLRWVQKNIASFGGNPDDVTILGYSAGSASVDLLMLSKSAEGLFHRVVPESGGNLAAFSIQRDPVEIAKTFAKQLNFTNVDDINALGEFYKTAPLELLTSDPFFYRTDSTFMFSPCVERNMGEETFLTESPLTILKNGNYKKLPVLYGFAEMEGLFRIDFFSFWKEKMNENFSDFLPADLKFKSEEERQKVASKVKRFYFGDKPISEDNILEYVNFFTDVVFAYPMLWATKLHVEAGNNQVYLYEYSFVDEDVPVVPHTNIRGANHCAQSFAVLDGKNLTHLSHTDESLATPEYQEMKKTMREIWYNFIKTGKPVPDGSSLPAWPAAGADRSPHMSLGQKIELRGVLLEERTRFWDDIYQRYYREPVPPPAPPSKSRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2L0</accession>
    <name>A0A835L2L0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="9 10">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_007261</name>
        <name evidence="13" type="ORF">HW555_009314</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="9">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000202">
        <property type="protein sequence ID" value="KAF9412078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000276">
        <property type="protein sequence ID" value="KAH9640690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2L0"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001060">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000607">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9412078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9640690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="697" mass="80770" checksum="ADD34BE8CC4CD562" modified="2021-09-29" version="1">MAKKKGDEKVNPQPQSDNEEPNFDEEPDFDDPEGFVDDIPDEELLADLLEQKPKESDSYENVVVVDGCPQVGPERLEKLQSVINKIFSKFGKIVNEYYPTTENGTTTGYIFLEYSNPQNAAEAVKATNNCKLDKQHTFLVNLFTDFKKYSDIPKEWEPPAPQPFKVQSDLQWYLMDPDAYDQFLVGIGTGVALQVWQNALPEPALLQERPNWTETYAVWSPLGTYLATFHWKGVALWAGPKFSQFQKFFHPEARFISFSPCENYIVTFSPTGDRGEDKKLIIWDIRTGLEKRSFPPPDEYVTWPVFRWSKDDKYFARLGQDMLSVYETPSFGLLDKKSIKIPGIRDFSWSPTDNTVAYWVAEDKDVPARVTLLELPNRTEIRSKNLFSVADCKIHWQKSGDYLCVKVDRYSKVKKDKNEIKYSGMYYNFEIFHMREKEIPVDSVEIKEPIQAFAWEPVGSKFAIIHGDPANICISFYQVNTGQAPTLLMKFERQPFNHLFWSPSGQFIVLANLGLTGGALEFLDTNDFTIMNVSDHYQMSGIEWDPTGRFVVTGVSSLKSKIDTGYYIWSFQGKILRRVMKEGFAQFNWRPRPPTLLSEKQQKDIKKNLKKYYSQFESKDRMRSSKASKELVAKRTEQMKKHMEYREAKVQEWNEQKPRRLELRNYVDTDGIDVDSTATSVEEVVEFFVKEEQTVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2R7</accession>
    <name>A0A835L2R7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000894">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="918"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1177" mass="136425" checksum="0B23A3DB7AB81E31" modified="2021-09-29" version="1">MQTCGKNANIDDENALKNQDSNDGIIPIHDKESEPHPMENVVFVWNNFNQNNPNKFEMPLDISINDDSTLPAESQRNFDAEIVDDNESMNLSPSQAIGRKVFKCPHCPFFSTTASRFHVHIVGHLNKKPFECSLCKYKSNWRWDITKHIKLKSARDPEHNEAKVLMTDETGRRNYSKYNKFLAMPVLNENGENEFHYLDPNTAVDSSMEIDEPFNDMSEVMNVQFEMQPLNLQTQHAEDKNDFLENRALDDVKKPKKTLWKCKKCNYKDPSKEALLEHVRQHSRSDGFHEEPKPVPKKLENNTPDPADLAYRCGHCNQLSNWKHVIQRHCRLKHDGVIKVITTVKPKPDPPMNINEINIDTCNKCPYRTSDKKLLIAHLQQHQPSASSIFKCYFCPFFVKDEPELIQHLLLHGITDPEDYIAKAMGAKSPAPEPQAPAAPSMNHTKRHKCIECPYETNSKSQFMYHEQFHRLPADTPYKCPECNYSVSKRHLLHQHLRVHGIATKRMESEAELEASTSSQNKSDSKADYHNNLDEIPYVWVSAKNEFHKMYKCRYCSYVNAIKCKIPNHEKIHYVVFENNDTTIYKCWECKYTCDNAARLSEHSKMHGEIYGRIYCPVEDDIPDEEQIMKLRKVIELEKITNPESCSRDESTTENGEIKIIYFCQKCPARFLDEGEIEVHKKGHHESHPNKCKSCDFSVTEEDELTAHSSVHTDEYHTKTKMLKFIHNTHPSHRQPILELVHCPKTSEITWIATGPCKLETAETHTKKLGESKSVPRQYSCNQCPAKFFKNSALTYHMGLHGGEGEYKCKKCNYAVKNIGNLAKHELLHENENKASCDYESGEDMDYKNIPLSGTDLFQRKTEAQKRVLTDKDKLVKPNDHFPPVLQADPQFGYLMHGNPEFIYPTYLKNGRQKEKRYKCHKCPSAFEKREQYKIHLSLHGSKQRYKCELCDYSVKYYANYVQHMRKHQMNDEAQAERKKGNDTFMESENQEDVKQEDSSDNIKLAIKTMPRGAPKSDFQQFSISDQQTLRLLQRRRSMNISGKDLNTSDTSPTKERKMHMCILCPYANQRQDSLNNHYRRHDDSDVLNAGGHKCPHCDLAVVQSHFLREHLKTHFNYHKTLIPECFVANEEVSFTITKLDDDSKAVDLKLDIQNKSFVGNDEKIFVKIKTGELLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L325</accession>
    <name>A0A835L325_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000180">
        <property type="protein sequence ID" value="KAF9412709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L325"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="150" mass="17353" checksum="132F391F3C5EFAB0" modified="2021-09-29" version="1">MGSFETEAKVTKDFIRLIKKHPLQIKMLSNVPTGMYILPVMFTLAVNYLIILLQFNHGMSRFEEFKPIIFILISYMTLTILPILAGHKIYRQDSYGPDAKLLKDFIRLTKKKPLQIKLITKIPVGLYLLPVLFAIAINYVITMLQFNHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3H8</accession>
    <name>A0A835L3H8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_008366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000161">
        <property type="protein sequence ID" value="KAF9413384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3H8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9413384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="479" mass="52981" checksum="50A5AFE12AF760FA" modified="2021-09-29" version="1">MTCINKSHAGIEAANISYAAAALLQSLTCVAPVIPGDPFCGDIDGVPLGQRGVLPGPTQINCRAFRATRERNVPPLDPCCQESATLRTPNAVPQRSNSIIMKQKDIRPAPSLIEYKNMRFLITDRPSDVTIQSYLQELRKHNVCTVVRVCEPSYDTAPLKAENIEVRDLAYDDGTFPPANVVDDWFEILREKAQNKPEAAVAVHCVAGLGRAPVMVAIALIELGMKYEEAVETIREERLISILFRKMASNNFRARKLVHMVVNTDVCHDNSVRNTELSTSTLTIEIEPEDTKKSEDEIFTDRQDIASSQDVVNADFSLNLSSAALGDIRVSDYSFSKDESFGLLCNETLTHSLMGSPVADFGTEDEPTTSQGLQEIENQRSNESCPDVDNAPTTSNNQILVTDSVMQNEDNEAANRLVCDALKGTTKKGTPRIRKLYTESTNTRKEAKKQKKIEKFCVKPACTTSCKKNVERNFQSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3R8</accession>
    <name>A0A835L3R8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Raf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000430">
        <property type="protein sequence ID" value="KAF9407842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3R8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01816">
        <property type="entry name" value="RBD_RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="6">
        <location>
            <begin position="129"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50495" checksum="07BA0AA84BFAE51A" modified="2021-09-29" version="1">MAVTREKENCSRKINGNIPALSLNSDNMSTSTDSDDVADPTYEIRNIQSIINVTRENIDALNAKFAGFQHPPSLYLSEYQELTSKLHNLELRERTLRELLQCESPDRSEEYSLQDDSKKFDTLTRQPKVFLRAHLPNQQRTSVQVKEGVTLRDALSKALKLRNLTCEMCEVVRTGNDLVIPWDIDITMIDAEEVTVRTLDKLPIMSHISHQFTRKTFFTLAFCECCRRLLFNGFYCSQCNFKFHQRCADKVPSICHQVRMTDTYYAALLAQNPETQAGILHFPPHFGYHHMISRSDQSKSISPAKKMKEFDVHWHQHPRSLNQQDRSNSAPNVCINMVQRPMTLAEHQRKHNQGNNNSPQSSNYLTSGRHKQDDKDKAGDQQHSQSTQASPTGTLRPRRARARSADESWKNALSPRESYDDWVIHADEILIGARIGKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L440</accession>
    <name>A0A835L440_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000390">
        <property type="protein sequence ID" value="KAF9408336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L440"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="21693" checksum="D772DCBEE38459AE" modified="2021-09-29" version="1">MVILHSDVTLAHRCKGLCSGVARQYVLAGDTCDEEHSSEPTAPRHSISRPCLINLQLSDVSPSGESCQSLFEESVSNRRAARKHSSSQITVLAAQSARQSVSAASSAAPAPQTALAAAPSCKGAPPHNRAVSQHKVLTPATNPLREYNPSTLSTVLVSSHVPANSPTDGARVAVAANSVCSSNGCAHKAAHPAHQHAATAQPRGPTHADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L497</accession>
    <name>A0A835L497_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000374">
        <property type="protein sequence ID" value="KAF9408584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L497"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21065">
        <property type="entry name" value="NURR_Syncrip-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000175">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000213">
        <property type="entry name" value="Uncharacterized protein, isoform R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="248"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="343"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="538" mass="60613" checksum="50270B6E8F7B3E2A" modified="2021-09-29" version="1">MQMAEGNGEIPIEEVPGKDSDVGRTPDYRKLIDYGLDPKVAAKLDDIYKTGKLAHAELDERALDALKEFPSDGALSVLGQFLDSNLEHVSNKSAYLCGVMKTYRQKSRAGVQGAPALASTVPVKGPDEEKIKQILARTGYTLDVTTGQRKYGGPPPGWEGGTPGAGCEVFCGKIPKDMYEDELIPLFERCGTIWDLRLMMDPMTGTNRGYAFVTFTSREATQRAVQELDNHEIKPGKTLRIKISVPNLRLFVGNIPKSKGKEEILEEFGKLTAGLVEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRLKVWGCDIIVDWADPQEEPDEQTMSKVKVLYARNLTQEITEDALKEEFERYGTVERVKKIKDYAFVHFEDRDCAVKAMQELDGKEMGGARLEVSLAKPPSDKKKKEEILRARERRMMQMIHGRGGFDWCSCSPPLKGLCCVFIDYDYDYYGYGDYRGGYNEPFYRYDEFYFDYAGPPQPSAVRQPPNRPQPDDELGLGPNSLYYDLTGGIQFSILYRIDPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4K8</accession>
    <name>A0A835L4K8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_005442</name>
        <name evidence="3" type="ORF">HW555_005374</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000635">
        <property type="protein sequence ID" value="KAH9633808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4K8"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01794">
        <property type="entry name" value="Ubl_UBTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="25988" checksum="72CD7FC8E3B9334B" modified="2021-09-29" version="1">MGGCIGITRSGSGPIEESSATVSRPNSGGLRKNQSLCHETIRWKSDVPLTEGQLRSKRDEFWDTAPAFEGRKEIWDALRAAAVAAEAMDFQLAQAILDGASVSVPNGYLTECYDEWGTRYQVPIYCLSPPINMVKEASGRDSPAEWSEPVEGGTEVSLRLRLSNTCKDVDLAVYSRHTISQCKNKLHAQENIEPWRQRWFYGGKLLGDRLLVEEAKITAGYVVQVIVSTDPQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4P2</accession>
    <name>A0A835L4P2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4P2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="34870" checksum="A053400D249AA15C" modified="2021-09-29" version="1" fragment="single">SMVRDYKRRTNRGGWSEEQMKLAIQAVLDGKNGYKSASKTYNVPQTTLERKVNQARKRDNNILNVKVPLGPITTVFSEEEEQILVTYLKEMEGRLFGLSTSELQKLAYELAVRNNKQHKFNELKEKAGKDWLRGFLHRHPDLSLRKPENTSAALSVGKYFELLGKALDDNPFTPDRIYNCDETGISVVPKSRSKVIAATGKTQVGALTSAEREATEIELNAETEPEVDITPTPYVAVIPQETLAVPSTIISPDPQMATGSALNSSANNVDPVAPTTSNLVQQAPGNDSLDTSFNLVSPKQLMPYPRMAEKRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5P6</accession>
    <name>A0A835L5P6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5P6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="790"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="847" mass="89451" checksum="4CEEC0172677A5D2" modified="2021-09-29" version="1">MGVPAELQTEAISIVHQFLQNIDKSLAQEFLKKTKAKPRVKGLPSLTDILTEYNKHKKPQKAAESSDDSSEDEAPQKKPVAQVNGKASAPKKAQDSSDSDSSEDEKPKTQAKPKAAAAPVKKAESSDDSDSSEDNATAKPTKQPIKPSNATPKVVKKQESSSDDSSEDEKPKPQQKPPVKAVPPKAAPVKKPASSSDSDDSSEDEKPKAAAKPAPKPQVKPTPAKKQESSSDDSDDSENEKPAQKKAAPTPAKAPVKAVPGKKQESSSDDSDDSEDEKPAQKKAAPTPAKTPVKVAPAKKQESSSDDDSEDEKPTQKKAAPTPAKTPAKAAPAKKQESSSDDSDDSEDEKPKAPVKPVGSVGTPKGTPAKPATKATPAKKQDSSSDDSSDSDDDDSKPKKTQPAKTAVTPAKPKATPAKKQESSDDSDDSDEDEKPQKALQKPQPTPVKPAIKATAKKDSSSDSDDSSEDEKPKATAKTPAKTPVKVAAKKASSSDDSDDSDEEPSKPAPKTPASATKPKPAAKKKQESSSEDDSSDDDKSKQKPAQKATPAKKAESSDDSDDSDEDAPPAKISKKESNDQVAENGVQTGKKRKASEGDSNAPAKKPYSNFVKGTVSVSTPKEKSNGVSKPAPFRRVASQPIEVDPRLKDNSFDAKEGESHEGEENDEETEENQSGGWNQRGRGGFNRGGRGFNDRGRGGFRGRGGDRGGRGGFNDRGGRGGRGGRGGFDRGGRGGFDRGGRGGFDRGGRGGGDRRGRGGRGDRHSWGGDRGGFNKGGFNDRKSFEGGDNAQNKKISGSRGSWGERANQDLKHTRGKSFKHEKTKKKRGSYRGGAIDTGVHSIKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L669</accession>
    <name>A0A835L669_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L669"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="457" mass="52207" checksum="292D562D6D961586" modified="2021-09-29" version="1">MATFTTDGKLCIERQLEVNTSVKEFDDLITLFDINETCRWITENNFLKVCLQFPDELLGVSTKVYEEIRKKVDVDLYILGDTSYASCCVDSVAAMHVQGDAIVHYGHSCFSKTNIPVFTVLPKHSVNVEATIKALGETFHADVRLCLFYDVGFNHCKDLISKHWFECYPLSYISFVEIEEKPNKYLGRVIRNKDGEEFAVEVLKDCMCIHLGTRGQTLFNYTISIAASAWYLLDPNTNKLESLEETAWFKRRRFLVEKCKDANVVGILVCKLAGEQTKEIISRMKQLCKVNGKKSYIVSVGKPNVPKLANFPEIDIYVMIACPENDLYSARDFYKPIVYPYELEVALNSNREPYFITHVTDYEQLLPGRPHHCDINHIQETTDVSLITGKIRETKVDTHDGSSTDLAEKQNWALESIGQNLQDRSWKGLEQKLGETEVKMAEEGRKGIPIQYSDEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7E2</accession>
    <name>A0A835L7E2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_003028</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7E2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="13"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="98"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="312"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9420842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="413" mass="46718" checksum="AE1E51304548BD42" modified="2021-09-29" version="1">MKIFIMSKIKAGPVVDVLGDEMTRIIWDLIKEKLILPFLDIELHVYDLGIENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDENRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWEKPIIIGRHAHADQYKATDFVVPGAGTLELIWTPPNGEPIKHVVNEFKGAGVALGMFNTDASIIDFAHSSFKYALDRKYPLYLSTKNTILKKYDGRFKDIFQEIYEREYKSQFEAAGIWYEHRLIDDMVAYSMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVEAEAAHGTVTRHYRFYQQGKETSTNPIASIFAWTRGLLHRAKLDDNAELKNFAETLEKVCIDTIEAGIMTKDLAICIKGMNNVKRSDYCETFEFMDKLAENLKKSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7S1</accession>
    <name>A0A835L7S1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAM20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_002619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7S1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="9">
        <location>
            <begin position="135"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9421404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="400" mass="46091" checksum="82F2641E6F253389" modified="2021-09-29" version="1">MKLYYTRVSSSFQWADEESLFPYKNGAAGQILQAMRTSQIAFVDNAPKGTQLKLLLVLKGNQKLYFKPKRYNLTDVIRGNIYAGYDRHNSEVFTYYLAMVLNYKWVAPSVIRRINMKYDILAHAMPGFKRTMVKNSQGSDCIYGKCYYCKINETVCPDSTGHIEGAGILYLDKYFKVNKSPWRRSYNSMKMEWENDKDYCKKVSSLLSTKRILNLIDIAIIDFLIQNGDRHRYEVYKHKILLLDNGKGLGNPMLDELDILAPLYQCCIISSKTWQMLELVSGGSLTETIQILASFQGEKLTTDDHYRAIERRLLKVYATVIIICLILSNILITGEEPQPLLCPTQDRMYGEQYGGKKVLKPIGILLKLWTLCYRTVPRPSVEHINKQSILQLGKMVKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8D3</accession>
    <name>A0A835L8D3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_011002</name>
        <name evidence="16" type="ORF">HW555_007969</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9414016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000476">
        <property type="protein sequence ID" value="KAH9636806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8D3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9414016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9636806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="130" mass="13328" checksum="34AC74E959C1D26B" modified="2021-09-29" version="1">MLSAARLIAPAARSAIFNNTAAVRTLAVVPTHTQIPTAPAQLSAVRSFQTTAVTKDIDSAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMMAFLLLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9A6</accession>
    <name>A0A835L9A6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1366" mass="159248" checksum="A681B46FBDE4E1C7" modified="2021-09-29" version="1">MDSLNENYHLRKWYLQRDEVPTQRMMKKKMSPALAGIYFQSMNQKLKQIAGLEPSLKGGGNWYLPPEELLKGRAVLRPVQKRILAKLNHHSIEDIGEKLDKAHQKTIDNDKRKVITENDEKWRLTITDIYYQEWKDLSKEAKQKNTEQIIKAIESFACMYRQSIQRIESLCHEVVTADINTIKSNIQRAMTKKYNVTLKCEAISMTNEYDKKLMEEKAKLKAEFIENVENHRTDLGNQIHDIYVDKLTATENLKDYLKRLNLACQVYVALKEHEECLNDRIESEYKHQKVTKKMTNTIALQNAMIETKKQRENVRRDHVNNWRKKLFYMIKKFQLFVTYCLNTVPENAEFFINLEKLMLLQINLVLEKPSDKSIFEAEEKMCNIPLIQPKPFYVFCDKGYKAKVDHNLCPKLGGKASASSSLLSAVIVNKHCLYAACDNFDQFTYRIKEYLNGNREDDGAVQDDHVYENTVPLRKKSSHKLFEVKLESSIMQVLQQEINDLQELYLTKKPETCNFCKMPNCSCTLREGVSVVNSRLTKTKVKSTEPPNENNPSSVKDIKLSHEKEPKRENFLLHMESKNCACISKMCKVKPLPSYMTKTDYGPSLIPNYEICSRATLNNLVKKVRKGVPTRTAPALSKKKDASTQYNDEEFNSICACVADETDRWIKNANSTYIWDLEDLADLSQFLDVSGSSSQESRLFAQARAHEISKLRKYYLKEQKVPTQSVIRATMSDKLADVLFKSLSPKFKGLSGFDHPIKGAGNNWIICPKQNLDKSRAVLKPLDNKHFAKFNHTGIEEFGEQALIAHQTASKKERDKIVYEADIAWRNKIKKDINEYWKEKVKICERCNADRIRDVFHLFSDVYQKSFKKIEKVFHEAIKSDVETTLLREQMLIKKRYNKFYKIQLTRLTEEFENKINKEKARLKAEFINNVENSRTDMATKVHDLNADKHEVYESMRKFLECQKIACQLYVLLKEKEECLNEIKELKYKHNEHVQTLTEQTKLRDVEIRLAEQKEKKQAELNSMWIKKVRHVVDNFQKFITYSLHILPQQAEFFINIEKLMLFQLNEALENPSTENIFEPEKELFHTPLPQAKPFYLFCDKDYKAKIDQDVCLKHRPSDSMLPAVIINGRCLYAACGNFAQFTDEIKDYSFMKNVQNADVNDDIDYGHVEPVKYSETQQLFELKLQSSLMNMLQHELSGINNVPSRTDDISNSYSSFFEDSDILSCENEDDINEASIPSTSEKRVIPFSEIRHTEHERESKLKSYFEYESAQTRDCIRKPVVRIPPYMIGMSKYGTLELPNYERCSEATLKKMVKKARKVEKLPQGTPKAISKVKDAATQYFDEEFNYISQCLCQSKFDKENPVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9B7</accession>
    <name>A0A835L9B7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-Maf-inducing protein PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052813">
        <property type="entry name" value="CMIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056429">
        <property type="entry name" value="PH_CMIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25480:SF0">
        <property type="entry name" value="C-MAF-INDUCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25480">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23066">
        <property type="entry name" value="PH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-Maf-inducing protein PH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="585" mass="65304" checksum="8171D4656A687ABB" modified="2021-09-29" version="1">MNPFGLLEHPLSYSCMQEVYCISRWDPARKYCLRIVMPHGSLLLQANDAYTRDQWYHSIIWRRNMIRYKNFLTKTVRKEVVLKELKNMVDFVMTTPLQDESVTRAPLQILTDLLSENKESEDWEEWAEMVTSAAAPLLAERCAAGDLCALLARLCRRRPRAAPLPALAPPVRRVLTRNVDFARAPNGRRLVRDYISALSAHNSGSSLVRRFVEVTHGNRATCPYPRAAPNLAAVALAALDDHYRDSATPHVCDESEEEVLCFADILEHMCEYEDWLVVVGAVLQPVPLCAGAMSCPRVAKRLGKLLNALAHDPRCAAHACVAPARAARLCPPSWLRAAAPSDPLLALPNEELCQIWGDMLGGLLNCCCKRKSFLQSMSKQLPDFVLVALTAHPAAIEALCLFLEWEVTTGEQTQLEIIATLQGTELGQKYYKDLCERQQNLQRLQSEGGPRRLALPVRATDADVAELLDAGALGNLECLSLAFTSVTSACAHHLIKLPSLRYLNLWATKFGDSGVQLIAEHLPKLQVLNLCETPVSDKGIEALSGLSNLRRLNLNSTKLSAEAFEVLRQRLPHLQEYDIRYTEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9J4</accession>
    <name>A0A835L9J4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of many from the eggshell of the gypsy moth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the chorion protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9J4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042600">
        <property type="term" value="C:egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005213">
        <property type="term" value="F:structural constituent of egg chorion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007304">
        <property type="term" value="P:chorion-containing eggshell formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002635">
        <property type="entry name" value="Chorion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01723">
        <property type="entry name" value="Chorion_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032298557" evidence="5">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="390" mass="39787" checksum="366B24DCF5915A87" modified="2021-09-29" version="1">MVSSVVFVLQICVIQYALSQETDTPTQTNMNQFRTNNRNTQVEALESGSAIGTATKVAVVPNQQNNYGAHAMPSSNDFLLTNLGLSKTVIPRTAKNGFRTTQLEGQITTEASGLVKDTLKKVPSVPKTPVNPYRHLMVNNNGYINPDMANIALGIGSSRQAVNGAGNTRLEGLESRLASNGAGMPSHKFNGAGMPKIAQEGFGTGTVGTNGELPMMWRDTISAQSIGVSCLNGNAVVAEELALGRALGAGSLVYPGNNVYGLAGNSFTPSNGGGFMVNSFSPISPTGVTVISENAIEGALAVNGELPFLGAVAVEGALQSTGAGGINYGCGSGIVGIVSEGVTPVAPTGPYGIAPGSRAYGPSLPGYGAPNFGLNGLPAPSCGYNGVLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9X3</accession>
    <name>A0A835L9X3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="373" mass="39093" checksum="18A74DE637792FC2" modified="2021-09-29" version="1">MTKRLKLNVLNIASGYQNLNDVFSGQETRIYNGFSRLVIPKSIPLRKLDCKYYQQDYVKSTTQNFAKLVLSEPLRNTTVARNFSHIPLTGKWLTTAHTFPPVTVTPWFSFPFQTSYNFYYDVKNPRCPPPAPKTKGGESPCGNQKKGPVCPPTTSKVDPCSRKSKPKSNPCQRRKCTFTVPMKLCRFFSTKACPPRKGGGKGSVCGGRKGGAGGDDKPRACRSRKEKAGGGGKPRACGSRQGGGGKPRACGSRKGGGDKPRACGSRKGGGGKPRACGSRKGGGNKPRACAKRGSGGGKPRACAKRGGGGKNPCGGRKGGAGRGKNPVCGGRKGGGSSSNPCAGRGGGGKGGHAVLPERKCGGGDKSKKPKCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAE2</accession>
    <name>A0A835LAE2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin-related protein 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Monothiol glutaredoxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_018453</name>
        <name evidence="9" type="ORF">HW555_001521</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000818">
        <property type="protein sequence ID" value="KAH9630537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAE2"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9630537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="146" mass="16427" checksum="C2F33E897D0C513F" modified="2021-09-29" version="1">MNSLLRRSIFPIYANSLKLSCRSFADVPIKDKIDTIVKNNKVVVFMKGVPDAPRCGFSNAVVQIMRMHAVPYDSHDVLSDEDLRQGIKDYSNWPTIPQVFINGEFVGGCDIMLQMHQSGELIEELKKVGIKSALLTAEESKKEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAL9</accession>
    <name>A0A835LAL9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAL9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7667" checksum="D78AC290BE2D23CE" modified="2021-09-29" version="1">MPPYVQEFNRKNVTTAAPAAASDMDSKPQESTSNSISTQLNEPNRIGDSNVMTGEVTNDPANVNVTEKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAU0</accession>
    <name>A0A835LAU0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="530" mass="61554" checksum="9329C5BF6FAB19EE" modified="2021-09-29" version="1">MDGSSNYLKYIMDGEEIDFRSDLSSDDEFLCAQLQEAGLMIKQKRRKQSCKEDIKRIKLDFDQKHTSYSTDFKTSNSSNKYEIIATPINEQNFGETMKTILSSQNNQKIVFEQNIDLDIVENIDINNLQIIEKVGNEFFDLQKEPPEFNTVAIEYPQSSVLNVVNTESENVLQELGNVVTSKSFPTSNTDILVSAITQDPTADEIIDSDNNYQGPHKNDLNQENVQESCASATPSCSSKVVILSNVPYHGDLLSHKKRQNKATKDPKKYKRNVNKELRMKGENYLGYRRDRKAKTNEKFKVKQDVFKPARSMKPPCNSAFCKKSKLRSCDNINEQQRQYLFEHFWKNMNWEQRRSFITSHVNKVPKKITKNPESSKRTDSRTYVLTIDNVRHQVCKKMFLATLGIKDWFVRYWLTKTDCAMPPDSSTSTSNRINPKKIEDHKYVEKFLADLPKMPSHYCRAKTSREYLEPIFSNMTQLYHTYKDNCELEGRACLARIPITKRKYEDLQDLKSVLPSSCHSFYDDLPHSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBA2</accession>
    <name>A0A835LBA2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_017992</name>
        <name evidence="5" type="ORF">HW555_005334</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9628017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9628017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14997" checksum="DC501D0C993B5A21" modified="2021-09-29" version="1">MAKPVDLELKKAFIELQLKMVETSEKIQVIDSQIDVLKRVLQHVDITQREISTFPPATKTYESVGRMFLLTDLDEVKNNLKTRKSQLTTRITELENNTQYLEKNLKESEDNIREMVQQRKEQSDTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBF9</accession>
    <name>A0A835LBF9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PDZ and LIM domain protein Zasp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09455">
        <property type="entry name" value="LIM1_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09360">
        <property type="entry name" value="LIM_ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000020">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000069">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000073">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2538"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="404"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="2077"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1962"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2206"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2480"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1373"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1962"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2210"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2480"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2491"/>
            <end position="2505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2571" mass="283301" checksum="DBCFFD17E38C4F07" modified="2021-09-29" version="1">MEDNKENIIGRGLGWGRAGGAAFNFLFLYSCCRIWEARVRRRSEDTHTLHVGSSNQLPVVNKPEGNRLGGRGRGEVNGGSAAERAGLQAGDALIRVNNTDVYLLRHQEAQDTIRAAGGNLELTVQRGGGTWRPTVTPTGSLPRPGSRSIGGTPTLVTNTSLKATPQPSRAFGSGHNNVAKPFGYMNGNDSVKSIVNKQYNTPVNMYSDKTIAETLSAQTEVLAGGVLGVNFKKNEKTYDAEKSAVFKVLQEEQNDPEPAEPVGPTAAQAAPVTGLRHVQAPVTRPDAPINNTGGLPPGQNICEECERLITVARAGTPCSLHRTHRSRSRTPRVVSTPQPTQPAPPVARACAGTQTPQEKLAPEPPHRPSIPMGCHEVLPDGRIALGAPALPQPRDALPVVNDTPYCSDCNRYIIGVFVRIKDKNLHVECFKCSTCGTSLKNQGYYNLNGKLYCDIHAKLVARNNPPAPNLEPVTVPPGSRIPTNTYSTPLPPLATSNYTNGSSSLFSPSSNLSGPKPFGSSIGSAYSPSLSPRSAPMSPARPVTAPAPAPAPLAAPISAPQPAAPFAPTNPSDDEPPKYEPSIKPGAPACAKEQGTRVLNKINPNSDSTIADVQQKSMEKFIASSKQREEFTSSSVSYASAAMSSMTATSKSESVVQSKQSQVVQESTSRTIQSFSQESSECQSTTVYQTQTCPPKSFENSSDAIENIKTQMIQSKENIQSRTAKEVESTNITEPPNDQVKAQQPQKTDTKIESDNGSAIQVSAQINTKENNQVCNEALMQKNNEEIVVNQQTATFDTQSKTSIEKTQTEPPIANAHMAATENIQKTMNPSGLDPNAKSSMVDALTTAPDRPYSPLPTAQQPINLTGQTMAEEKPTQYDSEEKSELKECAEIKDVQLPAQPSPMFSQEKRGITPIPPIKTYNPPEKVAPPVPMPEETKPYIPPDFKIVIEPKEPRETTSTPLIEALTIAPDRPFSPVATYDQNQAISRESYDQNQTMSNGPYDQTQSIGRGSLREALTIAPDRPYSPFGTPGVTQSNQYMTSTTHVTETNLSEIVKPIATQTLTQTSDQLHSEFSTMQNTCKLQSSSEMSAFRPVPKQVFPPPQPEEFCKLTNFPPISNELKTSFTQATKTKQETTFSESMVVQQSSLSTSMATQGYSTVKTAQNYFEQLDKKESLTSTAVRSKSGLHKPDSIPPYQKNFEQLLSQRGISPDIYNAPAVLQRPVTPSTGTPTRPKEKSVEPHPTYSTPQTSTPKFQQVRTPVQQPPVQFHKDTPITMTFQPVTDDNFMRVPSPSRSSRPVTPNSLINKPAPIIPHYQMNLVTVEHLAPESHLFEPSSREGSRSPTPKPRSRSPAQGPPPNPLKAHAPRIKESAPQNYSMDSFSSQDPSNWRKQHERDQKEFQTAAEIYNTGGGNKNWASQPPIVKEQRHSNVGYKSENYTKGDMKIKEDSLIQENYGQRQMQSQNVIAQGNTTVQTTRKTFEEYERTQSAKVVEIRKGGSSIAGAYEQNMDCNIRPSNLNPKQVFPPPMMSLPSTQQSSSLNLTNQNMMSASRTIDNYDPKPSISGANQGPVCDPTPSTGSSVGAAARGKTFGVSSAPKRGRGVLNKAALPGSRVPLCASSSEPLTTSSPHKTEFKSPAEERLIRKMAKMALNGYEIGIQRKIKPADHIQSMADKIQDTVVTKHPLNSDGIPAVENNNIKTVERSYKTHENIQSIGDKIKDTIKNNHPANESTPKPNVLIPPPLPSTPIPTFNVHSTPLGHSINTNGEKKKYDTIPRTLNASLISDERVINNNDKSHNGSGYSSTEDLQKDKIDNNYLGTLRKTGIEKSSFLNSMNGSIVAHTNSDVKPELKFDTPYSNTLNKRKLFEKPDNLITNNKVNEKVNNAIELNVSQKINNFDYTSKNENGVNQDEDLIKSKEVSGQLYNNSLYSYKSPTNNKINSNGNEHGNDCVDKVVEEIKSIPDSDEKQNTEEEVVVRRRQKKNIRNDDGRRDSHIIARPLSTIQCADVAEGLYPVCHKCDKAITRGPFITALGRIWCPEHFICVNATCRRPLQDIGFVEENGQLYCEFCFEQYIAPACDKCHAKIKGDCLNAIGKHYHPECFNCVYCGKLFGNNPFFLEDGLPYCEADWNDLFTTKCFACGFPVEAGDRWVEALNNNYHSQCAKRTSKDRVSSPREVDLSVRHTPARSPQQMMYNSDTVYTTTTFRPVSPSPITPPLNTPSPQRTRKLETPLHFDGGLFSDIRSTDGKLLSKVTVDRVQQSSRHDITDSPSVYTDGKNYVDDIVKTETITNENVITVKFTPVPPELDSPRLLTPSQMYKTRQKTPVEYIKDNFEDLQSYKIVSSVVKEKLLEKENLTPVLNEGGIFENHDTFANTTCKENVYEKDSFISDSNVKEKLSTSLDTFEPIKRAPSPLANLFISEQLTKIDSYLQESLEVCTGVKDRYTPIPIIIEGEKSGLVDDAEMASCVKETYDQKEVNFSTTEIKPSSNNKREDEPLHRREKTTPEPYSVEYSKTNVSKLNSAKQAGVLSAIYNMPIHYHAAILCFLLIIYNLIYQYVKQNCYGSKNKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCA0</accession>
    <name>A0A835LCA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000010">
        <property type="entry name" value="PX domain-containing protein kinase-like protein isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF40">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="135"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="60375" checksum="564FCF3361F3178C" modified="2021-09-29" version="1">MAIFEKTSHTKALIDDTEKLSCTVENAQNINKHTEYILRVQRGPTKDISWNVSRRYRDFAALQAGLVQANIDLPLPPKKLIGNMQPAFIAERQIALQNYINEVLKNEVLALSLQVRSFLDPSNYSLDIAEQALQTVSIALRGDGRFELKGPLHDIGWRIRKHYFLVTDTESGTNCMLSWQSYGADRYLSDKDLQTAYKSLQNISHPYIDQVLAIHNLETGTYVVRRIHENGSLRDILYGTEYNKSHLAKYGNPRIRKPFTIGQIAHYGYQILHALKFLHEKGIPHGHIHPGNIAIDNQKALLMDIENILVGVPCLYRPHLLHLRRVSTAEAIDVYCFGRTLYEMAFGTPLSEYYCDYYPDESVLRLCLSSSSCKHGGPSLEHLLQHPLFARAPLNGLTMGAQNDARMHLKFPLALKEELKTAVCNIEARLKSEQKLVRSAKREVRIQEILGSEEEIKKQKRRAKKRESLWKSTSSLAETVRSQSASTASSPTPPALSHDTSATGSQTAASPCDARSSLLAAICAFDKSRLASVVDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCM3</accession>
    <name>A0A835LCM3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="658" mass="75116" checksum="C7DAA05913EB2A34" modified="2021-09-29" version="1">MNPSITKALWLLQLYFNSAIVCVAIILMFVVLNVMRNSHKVSFRVFEPGSDLPIIIMEPQKRKQYASAQLEAALLAINEGTSIYEASKTYGIPRTTLRDKRNNKYINEHCGKQTVLTKEEEKRLVDWIFYLGKSGFPVTKDQLLETVAKLVENLNRSNPFKDGVPGKGWFLKFMARHPTISRRITQNLPTSRSHITEEAVRAWFNRVHSYFEQNNLLDVLEDPSRIFNCDETGFFLCPKGKQVLVRRGSKKVYSRVANDEKECLTVLNGFQCCGLYPFGPDNVNYDKLLTKNANATSEESGDNADDISSHGSSTVTGNEKSVDDTEKFKQQFERRLSPEVLLMFQKSGSVWNGDETYKKLFEFWRDINPIDNTPLQQTFDNNLELGDTTLVNNIGEEETLTYEVSASGCLVPNRFNTVSNNVLMFPMDELLSPIISKESDTISLLSTQPESNLLEYVNEIPPKTITPSTDCVKELNSEDHNARTSTPKQSNKNHSDEPMLLLNKSHSDDTLFTTVNNETPCKSIQNSSHSRFIPKELNLTTPFKNALFFPKVDTKSNKRVSKKITPTVAISDEFMEYQKKAEEKKAQEEEKKKIRKEKLQRNKIEREKKQADLRKAKERKNMGAVSKPTSYRRSDNFVAVGKRSRKIGNRILPHSMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LE39</accession>
    <name>A0A835LE39_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LE39"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="22895" checksum="5D7A90A8D432278F" modified="2021-09-29" version="1">MQSTTIIPILLFSLFKLYYCVEIVTTAPGTTFYFAYGSNLLTKRLHINNPSAIFYSIAKLNNYRLDFNYQVDAWQGAVATIVEDQDSDVWGTVWTMDTDQLHNLDEQEGVSIGMYYPKNVTVTTPSGQQLVARTYIETKNPKKANGTDIPMERRPSNTYLEVIALGAIESHLPSDYIGFIFSFPTNGKMATKTRREELGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LE77</accession>
    <name>A0A835LE77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LE77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="23602" checksum="A07F589956D22F02" modified="2021-09-29" version="1">MEQDQRHDVIDLTNLTDSFSHPSSNQQQASSNADVIELDRDSDDSIFDRDLSSDGEYVDIYKNPKQRVAKLKATIKRKFREYDQRMERLEKLKREQIKQKEEKEKERLKKIKQTVREKCRAMRKKRDKCAVCNSIPKETTFGTCPICLDELGDEPMASTICGHVFCIDCIHKYLKHEPKCPTCRKDLKGSKVYHPLYLSQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEG4</accession>
    <name>A0A835LEG4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEG4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="10998" checksum="1A24B38D40175232" modified="2021-09-29" version="1">MVWYCWAAVPPLSRARSKHHTILYWNHFAVLSGPYLRTSRCLSLPKFPYDSKIYDLRRDLTLDAALSVLSEDISHNQMSSLDEFVNSPAWLVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LEJ1</accession>
    <name>A0A835LEJ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UNR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LEJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913">
        <property type="entry name" value="UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CSD" evidence="7">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="280" mass="31167" checksum="A9F7CE610C678FD8" modified="2021-09-29" version="1">MDSTMDDDSGQSKTRGANRFSLGYKNGPNDDLIYSSGFDKHSSLQQYCVNHPPIRETGIIEKLLHSCGFIQCCERQARLFFNFSQFSGNTENLKIGDPVEFELQYDRRTGKPIVSTVTKIASVVLRGTRAGREMKEKGDSTKKHSHENGRESFFPSKDDVEGSALLTGDAISLQKATNQRGTFGVCHSRLQNPAQPGKYHRLVGSIKENFDFITKGDLVLGDDVEYFIKTGKGNEVACDKTQLSSGSVVFDDVSSEIMRGQMLKPLERSFFLRATRNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LG13</accession>
    <name>A0A835LG13_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LG13"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="28754" checksum="6BBDC67944EB9396" modified="2021-09-29" version="1">MSAHEQMRAMLDQLMGTARNGETDRHGVKFYDDAVCKSFLLQCCPHEILSSTRMDLGECPKIHDLALRADYELASKTKDYFYDIDATEHLEAFIADCDRRTTAAKQRLAETQEELSAEVTEKANAVHELAEQIGQKLARAEALGEEGMVEESVKLMGEIDELRKKKAVAEQEYRNSMPASSYQQQKLRVCEVCSAYLGIHDNDRRLADHFGGKLHLGFITIREKLAELKTQPVTEQKQARRLPRTFSWSRQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G049</accession>
    <name>A0A835G049_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000893">
        <property type="protein sequence ID" value="KAF9404754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G049"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="237" mass="27443" checksum="EEEA5AFCDD7AEEFD" modified="2021-09-29" version="1">MSRDNCHKVLWDFISEGCSTDFMNNDDEECKKEESESFTILDIDHAMRSLHDQLKSRMADNFFGSKVRDIFRKLDEEERALFKGQVHIFLQRALKYIEERYDFSTDGIYKKFELLSLKPQELKLTWEVLSELPMILNIEDAINIDSLYSEFACLKTNCPGFDKFLSGNPSCVPGYKERGGMHQVLHGFPNPVVDREGFNTWLITVLDFVNKYHQTAFAANSEPTINIISTVDSSFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G259</accession>
    <name>A0A835G259_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit g</fullName>
            <shortName evidence="10">ATPase subunit g</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_006597</name>
        <name evidence="11" type="ORF">HW555_014035</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000824">
        <property type="protein sequence ID" value="KAF9405055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000755">
        <property type="protein sequence ID" value="KAH9631605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G259"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016702">
        <property type="entry name" value="ATP5MG_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017835">
        <property type="entry name" value="ATP-synth_g_mitoch_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9405055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9631605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="99" mass="10719" checksum="77682E655844C420" modified="2021-09-29" version="1">MASAVGKVPSLISSAIAQARPKFNIFMKYARVELAPPKLSEIPQIKAGIGKLLTSAKTGAWKDQTIKQATLNALVGAEVIFWFYVGECIGKRHIVGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G276</accession>
    <name>A0A835G276_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000582">
        <property type="protein sequence ID" value="KAF9406502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF136">
        <property type="entry name" value="PROTOCADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032924520" description="Cadherin domain-containing protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1591"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="181"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="312"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="410"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="529"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="641"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="772"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="897"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="1165"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="1287"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1700"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1716"/>
            <end position="1739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1739" mass="196427" checksum="5E8F012A85F08772" modified="2021-09-29" version="1">MAVDVRILTATLLLLAAATTGQQDRCGYMVEIPRPPRPDFPPQSFEGLTWAQRPLLPAEDREEVCLNEYSPDVFNPNIGHQTIYMEEEIEEHVAIAKLNYRGNNVPEVRMPFIFGAAHMLGAVIRRYPDDDGDWHLVITQRQDYETPEMQLYMFEVRVDGEPLVVRVTLHIVNIDDNTPVIEMLEPCSIPELGEPGVTQCKYVVRDADGRISTSVMKFEIESDRGDELTFELIRENIPSEWMWVYMVLEVKKSLDYKANPLHIFRVTALDSLPNKRTVTMMVEVENVEHRNPEWMEIFAVQQFDEKQEMSFTVRAVDGDTGINKPIFYRIETEERDKEFFSIETIGEGRQGAIFHVAAIDRDELKRDMFNVAIIAYKYGDNDEEGKPSFETTANVVIIINDINDQRPVPFQKEYTISIEEETAMTLRLENFGFHDRDIGPHAQYSVRLESIQPDNAHTAFYIAPTEGYQEQEFIIGTVHHHMLDYEDDNYRPGIKLRAIATDKDDNRHTGEAIININLINWNDELPGFKKDSYDATFPETVKAGFHVGTYLATDDDIGDIVEHRILGNAGNFLTIDMLSGDVFVTKNDSFDYHRQNEIFVQIEAVDTLGLPQNRATTQLVIHLEDINNTPPTLRLPRQSPSVEENVKDGHLITQGLTASDPDTTADLIFEIDWDASYATKQGMNAPPIEEYHNCVEILTVYPDADNRGYAEGHLVAREIRDGVTIDYEEFEVLYLVVRVIDRNTVIGDDYDEAMLTVTIIDMNDNRPLWVAGTLEQTLRVREMADQGVVIGSLQATDIDGPLYNRVRYTMTPIKDTPDDLVAIDYITGQLTVNKGQAIDADIPPRFHLYYKVIASDKCSLDEFFTQCPDDPMFWKTEGEIAIQITDTNNKIPHAETDQFPTEIRIPEDTANGTEITKIIASDLDRDRPNNVVTYRINYAFNHRLENFFAVDPDTGILRVHFTTSEVLDRDGEEPEHRIIFTIVDNLEGAGDGNQNTISTEVRIILLDVNDNKPELPPSNGEFWTVSEGELQGRRIPPEIHAHDRDEPFNDNSRVEYAIQSIKLTNRNVELPQDPFKIITINDFEEWKFVGELETTMDLRGYWGTYDVEIHAFDHGVPSLSSYETYQLTVRPYNFHSPEFVFPTANSKIRLSRERAIVNGMLALANIASGEFLDRLSATDEDGLHAGEVTFSIVGNDEAEQYFHVVNDGDNSAMLTLKQALPDGVQQYQLVIRATDGGTEPGPRFTDCAVTVVFVLTQGEPVFSENTVTIRFLEKDAGMAERIQLPEAVDPKNYKCTVDCHDVYYSITDGNDDGHFAVDPETNEIYLVKELDRSERDQHRIVVAAANTPGVTNAMPSSLLTVTINVREANPRPVFSRELYTAGILNTDNINRELVYLSATHSEGHPITFSIDWQTMVVDESLQNVEGDAFNINSETGVISLNFQPTSAMHGNFHFEVVATDTEGASDRAEVTIFMISTRVRVAFLFYNSEAEVNARRDFVAQTLSTGFGMTCNIDSVLPATEANGVIREGFTEVQAHFIRDNLPVPVEYIDELFTDINRIRDIQEVLRTQELSLLDLAAGGTTVLPGGEYALAVYILAGIAAFLAVICLSLVIAFFIRNRTLNRRIEALSTTNQDQTMDSDLNHAAVAAPNTNKHAVEGSNPIWNENIKAPDFDSISEMSNDSDLIGIEDLPQFRDDYFPPTNEAANPNFSPRHIANQENNFGSNSTPFSPEFANSQFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2G7</accession>
    <name>A0A835G2G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_013004</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="EMBL" id="JACKWZ010000557">
        <property type="protein sequence ID" value="KAF9406717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032747544" description="Glucosylceramidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="104"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="471"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9406717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="541" mass="60648" checksum="D7769472F4386A67" modified="2021-09-29" version="1">MMAPYKVCVLFGILAVCFIGACFADIPCEARKITGKSVVCVCNATYCDTISREPFVPNTYVVYSSSQSGLRFSKNRAELKQANYSDTGCIPTLVLNTKVKYQTVEGFGGATTDAAGINWKNLSLPLQKFLIDSYFSDKGLQYNMIRVPIGGTDFSTHAYAYNELPVNDTKLSNFTLTYEDFHYKLTSGTDPFHITFLSSQIPMIKAAMQASSTPVHVIATTWSPPLWMKTRPVYRGRSLLKPEYYQTYADYHYKFLEKYKEQGINVWGITTTNEPTTGLVGFIHSVNNLGWTAASMGRWIIMNLGPTIRNSTFKDVKIITGDDQRLTLPYWANVLVAEHPKVLDYVDGIAVHYYTDFLTPASILTEVSKSFPNKFIIATEACEGSIPILEKHVDVGSWVRAKKYAIDIIDDINHDVVGWIDWNLCLNVQGGPSYTANHVDSPILVFPEFNAFIKQPMFYAMGHFSKFVPRGSRRIEVTQKCGWKRSLWTTAFITPQNNVVVVLYNDGKATKVNLQLGSKQAVVEMEANSMATVELPPNVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3F3</accession>
    <name>A0A835G3F3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000940">
        <property type="protein sequence ID" value="KAF9404582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3F3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="119"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="3">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64639" checksum="F1AF4E42736D8A9E" modified="2021-09-29" version="1">MRSPLTPPSTTSLQQLNLGHGPSPSSLTATMQEAALPSTSETNVHLNLGEKTTVKKAKSRVFLTNTEKYLQDKLVAASIKLSKMKNRFKKLSVNVKAAKQIASNPAQTLIKLVQICNIKPGINSNIFSQLKNKADNMKIEQRLCVVMFDEVSLKSNVAYNERKDKITSLVDNGQNRKTEFADHAQVFMLRGLIYNYKQAISYTFASSATKGPERAQQIKDVIRGLQESGFIVVATVCDQGPNNRQALKLLINENRGIYLRKGEEPKENKILINDLEFTKDGVTKIAKCSHLNLLLKENPGKNILPAECKDTADLLLFMDNIFDSVNGSRQKNRNAKPLLGPATPNSAHHQIWIEGVQIFKSMKFVSNGKKQSVPSITNWVWTLSRINKLQNEFNVSSVWLRHLNQDPLENFFGAVRSQGCRNTNPTCDQFESAFTTLLINNISSVHTRGNCEKDFCDALYSLTINENAETTSTCSSFDFSNIIEFNFTPIEIKERDPRIVGPLQYISGYFLKKIKSKIFKTCTDCCNLLMEKNEIEYIKYREYAGRRWLCTPSKKLIELISNMQDLIKQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3K4</accession>
    <name>A0A835G3K4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000804">
        <property type="protein sequence ID" value="KAF9405138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3K4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="25645" checksum="94780E6F969FC0E9" modified="2021-09-29" version="1">MTLAQLYTPYILSYGTPGLSSGKAGWTLYECVDCGNKYKHKGSLQRHIKYECRKQPSFKCPYCVYRAYQKHNLLLHERHLHKDMPEKVDFVCNCYQQAKHLDLILNSRLQENQEIVKSSDVDFFKTMMQNMLPIMPMKTKNYWSHYDMSYECEKCKRKYRHKSTYRRHVTYECGKEPMFRCPFLDCTYKAYQKTHTDAHIKTKHKLMALEYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4R8</accession>
    <name>A0A835G4R8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000647">
        <property type="protein sequence ID" value="KAF9406051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4R8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="31611" checksum="334BFC582CB9AE7C" modified="2021-09-29" version="1">MSLSQLADVQASQKNLEELILNKMGEMESQLQTASLPKANTIAKLAEEFRCFRELVFGMLSLLRSQIQDFSKIVDSLDMRSRRKALIFTGISENEVDCKAFIVEKLHSKLALKDITMDHITQCHRLGAPSKDRARPILVRFMKVDQKSAVWRAKQGLKGSSIAIKEFLTRTRQSVFSKARLHFGMRACWTQDGVIVIRTSDGSRHRISSSDELDPLLVRYPKVARESTVAARGKPTNNEHLLLCPSPLNSQLMHGFVVVNTYFTLHKQIFMDHHSHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5H0</accession>
    <name>A0A835G5H0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000421">
        <property type="protein sequence ID" value="KAF9407944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5H0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="485" mass="52843" checksum="EF0EB894D16D5DEF" modified="2021-09-29" version="1">MTNSSLGLTLGSEKKEATLLSETQTVARFSPLWKQTLASSAPILMTFVSGLTSGYSAILLPQLKNNPGPIPYDENTASWIAAIAALPMAPGCLVSGWMMEKFGRKTSHFITCVPLLLGWILIAASSNLELMLMGRFFSGLCAGLSGPLIPVYIGETTEPKYRGFFLAGVSLAIALGILVAHIIGTFLSWKLTASICAIFPVITAGLLFLVPESPTWLISQGRIEDGAKAFYWLRGYGEEAKKELRGLIESKKALDSAPAMSWREKLVSLKNPELIKPLVIMVLFFCTCQFSGVNAVAFYSIEIVEKAVGKGIDHYLAMLIIDSLRVVMSVVACVICKQYGRRPLCFISGIWTSISMVGLSMFLYWKPANMSWLPLMFLMFYICAITIGLVPLPWIMCGEVFPTKVRGIGSGISSSTTFVAFFIVVKTAPGLMSTFGEVITFLGYGVVALIGTAVMYFILPETKGKSLQEIEERFRNGKKSVGPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G641</accession>
    <name>A0A835G641_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000417">
        <property type="protein sequence ID" value="KAF9407985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G641"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="663" mass="73243" checksum="24FE5319B303725F" modified="2021-09-29" version="1">MVFNLNDDGERAGGNNATTAETSSNRVVISGMSALMPGRNDLEEFNKKLYNKENFVVNQEPLWHSNHPEVTPYRGKIADLDRFDAQFFMVHYRLAQSSDSTSRKVLEQTYQAIIDAGVCPSELSSKRIGVFFGNGFDESFKLLYSFHGKGYSTLLGSSKTMIANRISYWLNLRGPSHTVEASCCSSLVVLQLGRDAIARGYCDAAIIGGSRIMLQPQHYINYNRMVPISFDGKTKCYDVDADGHILAEAITVLFLQKYEDAKRIYAEIYHMKSNFSYDNFGKYRDPAKWSKHLEKFYEEAGVSPSSVEYVEGCGAADPEADRAELQALEVVLCKDRKKPLLVGSVTSNIGSTGETSGLCGLIKVSKYVLIVSFFNLLKDVTRSQSQIPLMVLASGRQESGVQKILDHIKSKELDPEEIALHHGVYKTKILNHMARGFGIYETVNNKTVTRSEKKRYYDSAARPLWFVYSGMGSQWAGMGEQLMRIPIFAAAIERCDRVLKPKGLDIVDIISNPDKSMFDNILNSFVGIAAIQIGLTDVLRAVGLVPDNVIGHSVGELGCAYADDCLTDEEMISLSYSRGIVSTTMEFVRGSMAAVGIGFKQMSKICPPDIDVACHNGPGSCTISGPEEIVCKFVNELTGQGIFAKELQCSNIAYHSRYVAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G780</accession>
    <name>A0A835G780_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000443">
        <property type="protein sequence ID" value="KAF9407711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G780"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="688" mass="77357" checksum="221D5782643B6131" modified="2021-09-29" version="1">MKKVRFESPAKAFQSFDMNERECHSPRPLVERQMHANAPDLYSQVKVIPYSNDPVQLFECSNSSPFPTMTKTPLPGYQKSPEWSPSHDLELSMLDASYHEPRRPTFCRSILKPANANHIAVDDHTMKYTPETGSAPKILTENKAPKLPNILIKDDDFFIKRDNLDKFNLDMNPLTKQFNKLSLDKENDPFTRKSEMVQVAAINMQENVKSQPQPTRFEDTDCRCHHCIKKATLTNTQHVMNDRLPQHPRPNYGSPSTAQNGMRHSHCPCALPPQPRCSCCTPIPPARKCQCSPCGVDKTPSPILNAVDKKTWAIERYEQSKTSGSMEVEKQTNISKEKREPTVSDLFKIIKLQNEQLQLLQEKVDKFITASQQTQVPAQKHVAIETVESEQHKISIGVMTSFEMVRTSTVINKEILKTNDNAQIQCNRSQISIKEVVSKGQAPNPNFLDGITPVGDTMRAEFEAQGNVLTNTPMNGCVLPLAGVTEEKTLNELSLCNVQVDNATTPLMSPEQSLYLDVRDYSDSDADSDNQSNVGWTYYNKVMTHVNGMLQDSDMPSSASALYRNTRQQLQTVQMHIDKTNVSVTKRVKFGDDPLGLHQPHIYASTDTSLKMNQLAAKYLKNGPPIAAPQRPAPRPATAPVDMSFATRNYMERHKLLQGIPQPSKSASPGEMPRFLDITALKQQPKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7C7</accession>
    <name>A0A835G7C7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000261">
        <property type="protein sequence ID" value="KAF9410491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7C7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="86" mass="8823" checksum="D49251FA893D612E" modified="2021-09-29" version="1">MSDGHGEPNQLNSSRKESVAAANVPSDSPVTDPGQVRGGNTEAGAAGKFEGQRGKSGALKKSARYRSRSLSASSADSYSSTSYTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9C2</accession>
    <name>A0A835G9C2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000266">
        <property type="protein sequence ID" value="KAF9410362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9C2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032953824" description="Cuticular protein RR-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="698"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="137281" checksum="5254687F331307E5" modified="2021-09-29" version="1">MEMKWLLVTLAIGLAASDKLDHTYLPPPGAQFAGGILGNQDAPLEPPHHTQSGIGQTIPGNEQYHTSLGVNGEPVNFGDKIPKTTTFPPTEGFKPGNLPINPATGLPFQLDQGNVPFGFTQGQQNVQQFPGPNQSNKPDYGTNVQTGVTPQGSNSINYDQPPGFNQPTKQISGQYQGQNLVNPGGVQIPGSITLPVQNQAPLPIGQGNAQQSFLPIGPANQPFNQYPVKNLDNNGGVSSIPGGNQGFVQYPIQGPTNQGLVPSTVSPNNLQPSINGVQYDESQGPLPQGTYTGQPINVGEPQPAQTSYQNQGPFNTGEVSQYSTELPAVSGHTRPASTPSYYNGIASTTPLPTVPSSKSGYSSVKPVYRPERPQAEADRNAVILNYENVRSPNGYSYSFDTSNGIHADESAIIDNGTKAQGSYSYIGDDGKLYSVYYTADENGFQPRGDHLPTPPPIPEAIQRVIEQAAKDEAAGIVDDGSYDVTKYGDDKYQGTSTHRRPQNQSQKTITKKIYGPNDDLIRPITGIKDTEYDEGSQNQFDIPVSGTKKSSNNNLTMKRPSNKVIATNSGEDQGIVRISENSRTPIQDFDGNSRLVEEQRTINRVNNQNDQGTTSGNPMSNGKNIPYGDAKDGINNKGSKANNQDSLRRRPTSDNDKDTLVAKYPGANVDITSTSYPKTESVDFEDNYGKKIVSVKPNSFDESDENKDLEYDSVTGAPKVENKNQDPRKGINGNRQPGLNNQSENQKFPGRNDKQGNTNLSTISDYIENAAKQPTLHQQTTHQDKDGYQYQQPSTKFATRFRTQEIPTTMKPDQRNIEYVEGTTRKPFITPNIYEQNKKVSPSSTRRPFMAKEVTSLSENAYTDYKDDDYATDQDVDDERTSSTKSPIEKSGITSLYEITQKESRPQYAVEDRETEISQKLPSKPGHRENFENTKSVAPRYPYGPTTSVPLHNSRFGTTKAPQHTKPEDFRPSSPYFESTPAVGRPATQSSLGQTRPDPVNNSYQSTDPNSKYFDSNVVSGYPTSGYTSNLGTKSGNPGMSTPQNYYTSTFRPSQIYSTTSPSVPGYQTGSGVRFPVTPAGLPVGPTGSPVGPTGFPVGPTGSPVSTQDSAYHAGYHYGPPKSGNPSYGSDAGFFTPTANSRVSTSPTGPYQTTYQGSSGFPSTTLGPSLGGRQDNYIPSYYGSTTSNQSPVLNPQGNFRNQPSTPDYSSTITSSTPGSPATYDFSGLPNTHKGTTGYENEPFKPTYSTTYSPSTIRYHPWSLQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA04</accession>
    <name>A0A835GA04_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_004968</name>
        <name evidence="8" type="ORF">HW555_011069</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000307">
        <property type="protein sequence ID" value="KAF9409596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000894">
        <property type="protein sequence ID" value="KAH9628808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA04"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9628808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="340" mass="37148" checksum="BB949ECCAC205A7B" modified="2021-09-29" version="1">MAQNKKILKDEHLITVLLCALAIPLSMSMWIINLIYSKFITTNEGFDEPVVISPGRWLASCLIPLIIAVHGYRKKSVSLNGAVLGCALAFILTLSNYSFLVCLITFFISSSKATKIRPHIKRKIEEDFKEGGQRNWVQVLCNGGMAAQLGLLYLLDVGASERPIDFVTDYRASWLSIGILGVFACCNGDTWASELGTVFSDSDPYLVTTFKKVPKGTNGGISVIGTLFSTLGGLAIGISQYLTIYYFSEKSLWTYAPPQWPIIFFGALGGFLGSLIDSLMGATLQYSGLDKDGKIVSHSSLTVKHISGRNILDNHSVNLISTVIMGLLLPTVCKSLWPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA23</accession>
    <name>A0A835GA23_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="454" mass="49363" checksum="CFC57ED8E824A6E8" modified="2021-09-29" version="1" fragment="single">TLITAAAGTTVGWTSPTLPILLAPDSPIVTSPDQSSWIASIMILCSAASPIPAAYLADRIGTKKTLLLASVPYIIGWILVMFAGNVPTIYASRLISGLGYGIAYTTAPMYLGEIASDDVRGAMATLITVMSKFGILSQYCIGPYVSMLGLASFNIAIPILFVVTFSTMPESPYYYIKQGQKQEAEASLKKLRGRSYVRDELESMNNLVSENMKEKGRWKDLFYVGGNRKGLIILMGIYFTQQFCGSTAIISYAQQIFGAAEGGLGAEESCILFGTVQLLTSAMSSQLVDRLGRKPLLLISSCGVGLANVIIGAYFFMKHQNSEYLVSLKFIPIVVIPIFIFSYTIGLATVPFAITSEIFPTNIKSKATCVIQIFVALMTFAVTKLYQVVADNLGNYVAFWGFGALSVLGVIFILLQLPETKGQSFAAIQEKLYSPNKVVYEKDEDEMARVKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA73</accession>
    <name>A0A835GA73_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA73"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28739" checksum="3F4C6F7FBB9956CA" modified="2021-09-29" version="1">MEKVIQPKETINNVTTENNNMESNKNIESEIQNNNSKGGNETLETNSIETHGTTAAKSPIPNRVPKRSLKNIISPDDAKMMKFMDSFSNNEPKTMNRHLSFFNGILPSLDNYNDDEVLEFEMGVLQLMKKIKNSRQICEPSSFHIPSDHRGYFTQQYQNNIQEATNSISTNMTTMTSVQSPSSVELTTAASLLNPSSVESCYSNYTDDVPKTFYFVGGETVGAFDTNLKVQPSVDPSLTSTRCDNCVETAAIRSLYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAL1</accession>
    <name>A0A835GAL1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="400" mass="46745" checksum="64163FF32DD21E9D" modified="2021-09-29" version="1">MNVPSSEQEELFIRKLRQCCVAFDFMDPVADLKGKEIKRATLNELVEYITAGRGVLTEPVYPEIIKMISANLFRTLPPSENPDFDPEEDDPTLEASWPHLQLVYEFFLRFLESTDFQPTIGKKVIDQKFVLQASSFKYFDWSSKSLLALLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVGELLEILGSIINGFALPLKSEHKQFLVKVLLPLHKVKCLSLYHAQLAYCVVQFLEKDATLTEHVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPAQFVKIQEPLFRQIAKCVSSPHFQVAERALYFWNNEYIMSLMEENNHVIMPIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTASYKAERQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAW6</accession>
    <name>A0A835GAW6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_009312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus</location>
            <location evidence="1 11">Golgi stack membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000202">
        <property type="protein sequence ID" value="KAF9412076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAW6"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="50"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="187"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9412076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="426" mass="50071" checksum="23EA7CB62B3965F1" modified="2021-09-29" version="1">MLRILLRKIMRVRLRVLLWIVCVFTVSLLVTFWTFSDVNDISETIIDSKYPVIVWWNMDFHGISSIKYCSNGVKCHIYGKNDNGMQKYNNVGAYLFYASTLDFKNLPLPRQPKDIIWGLFHEESPRNVEELLHEKALSLFNFSATFSRFSDVPYPLQHIEAFEDIRSKKHFIETSKKNELLNEIAPIMYLQSDCETSTERDAYVKELMKFIKIDSYGVCLNNKELPSKFKDDYLNNLNEDEFLAFIARYKFVIAIENGACNDYITEKFWRAIKVGSVPIYFGSPTIRDWLPNNKSAILLEDYPTPKRLFEHIQVLMHNDRLYDEYLEHKTKQLITNQRLLDEHSFRPYQYDGVKNIDKLECLICERLHDKINGQIGVHIVNKSHYDCPKPLSALTLKVNPDNSWVYSWEYSRSNADSIYDKVINGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAX5</accession>
    <name>A0A835GAX5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000266">
        <property type="protein sequence ID" value="KAF9410361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032407260" description="Cuticular protein RR-1" evidence="5">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="25254" checksum="7AFAA46D0D7C4180" modified="2021-09-29" version="1">MKLFVVAAVLGVCLADRLDNKYLPPRGNAGAGGFGPGFGAAGAPGFGKAGGGFGGAGGAGGFGAGGAGGFGAGGRGAGGSGGYSGAGSGFGGAGAGLGGAGSGFGGTQYSGNAYNAPAGGQFNARGGNSADASAQILKLNSEVTAEGFSYDFETSNGIRADARGVATNGVQSQGSFAYKGDDGQDYSITYTADENGYQPQGAHLPTPPPIPEEILKSLEQNARDEAAGIVDDGAASRQYLAPNAGGRGSGSGNFNSQTGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB03</accession>
    <name>A0A835GB03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033101686" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="18"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="657" mass="74299" checksum="7D9619A18E75D403" modified="2021-09-29" version="1">MSLYVVCALLLLTPIRAFYLPGLAPVNYCIASDDTSKSCKTEIPLYVNRLNTEESVIPFEYHHFDFCTTDESQSPVENLGQVVFGERIRPSPYKLEFLQNVECKAVCTKTYRGSDTDSNKRLNLLKMGMALSYQHHWILDNMPVTWCYLVNEGGKTYCSTGFPMGCQVRKDMDTCTPIVNGHSSRIGAYYLFNHVDLEITYHSGSEEEWGVAFGENGGRIISAKVKPASIRHANPSKPDCSARGAELLIPTEIDSDKVFNITYTYSVTFKKNNTIKWSSRWDYILESMPQTNIQWFSILNSLVIVLFLSGMVAMILLRTLYKDIARYNQMECGEDAQEEFGWKLVHGDVFRPPRRGMLLAVFLGSGSQVFGMTLVTLAFACLGFLSPANRGALMTCALVAWVLLGAAAGYVSARIYKSFGGRRWKSNILLTSMVCPGVVFSLFFIMNLVLWGKGSSAAVPFSTLVALLALWFGVSVPLTFIGAYFGFRKRILDHPVRTNQIPRQIPEQSLYTQPVPGIVMGGVLPFGCIFIQLFFILNSLWSSQMYYMFGFLFLVFVILVITCSETTILLCYFHLCAEDYHWWWRAFLSSGSTAGYLFIYCCHYFVTKLNIEDAASTFLYFGYTLIMVFLFFLLTGTIGFMACFWFVRKIYSVVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBD8</accession>
    <name>A0A835GBD8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase-coupling factor 6, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ATPase subunit F6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000190">
        <property type="protein sequence ID" value="KAF9412420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBD8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.110:FF:000001">
        <property type="entry name" value="ATP synthase-coupling factor 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.110">
        <property type="entry name" value="Mitochondrial ATP synthase-coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008387">
        <property type="entry name" value="ATP_synth_f6_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036204">
        <property type="entry name" value="ATP_synth_f6_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12441">
        <property type="entry name" value="ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12441:SF10">
        <property type="entry name" value="ATP SYNTHASE-COUPLING FACTOR 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05511">
        <property type="entry name" value="ATP-synt_F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002455">
        <property type="entry name" value="ATP_synthase_coupling_factor_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111357">
        <property type="entry name" value="Mitochondrial ATP synthase coupling factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11448" checksum="BF18B2E9EEE47A18" modified="2021-09-29" version="1">MLTSRLMGGVKVAQTSVMVTRNLAAAQKATDPIQQLFLDKIREYKQKSAGGKLEVSPAIAKEMKQELEKLEKQYGGGSGVDMTSFPTFKFEEPKLDPINESLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC90</accession>
    <name>A0A835GC90_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000180">
        <property type="protein sequence ID" value="KAF9412701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC90"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0401">Integrin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033101284" evidence="5">
        <location>
            <begin position="17"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="310"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9412701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="863" mass="96396" checksum="A9047FF3BD43EC89" modified="2021-09-29" version="1">MDIICLCLVAWPSALAKYFTGDKEIFRPPRPLRNDSYFGYSITYDQKHGKLVISAPRENNIGVVYDCDIPSRTCTGLPVKIDRISLNPAYAHDFWLGATVKSGPDFVIMCAPRYTEIYASKSDEKGFNMHVTFGRCFSHQDGAIIEKKNINEAERNKDSESLMETRMDSFGWSIDVASDDSVLVGGPGMFHGRVMVYTPRSLPTFIKYNKMNMPEFDFGYSVASGMFLSTKLTYAIGSPYGTSGFGEVLFFQNLKFTRNLVKGVDTDVIGSMFGAVLCAAKISGNQTDLLVGAPTYATFDTYNLGAKSPTFKRRIVGSSAGGQFGSAIVNVGDLNGDRKDEIAISAPFENDGRGVVYLYSGHDLVSDKTEMTLNWMQKIEPEADYAKSFGMSLTPLLDYDKNGCNELAIGSPYEDKVVLLRCMAAITVETSAIFPNVQGRGASREVNYNLRVCLTVTYPTLPEKIIARLSTTVTMTHSSAKLAKMDAGGYTFEKSLNDRQRENCENIPFILPLDGKYDTEINYVVTTKLLEDPMELKKFDSSRVILSDRSVLQVVQTAWAAECAGKICVPNFSMTPSISFENGGKWDTGSIDLDMQQLNNLDEKVIVNVQRYNYCKDTVATENRKYTINMQPDPTGIVAKGEDITKKGKKITHVYTLTNSGPTHWVKLEVKVKLEKQDYLEDVSVHISESYNTMNCENDPNDKMVYICVVESLKVQKDEAKILIPMFIKPSTELEAILEEKNVTISSSISYEPVPSHFKKTSISTLVTLQEAKVPLMIIIIALLVGLLIVLIIAIILYRVGFLQRKKKKELENLRRSVKRQTILRRSTMPTQTNAQGSEERRQVLEGINDADEDILYFKNVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD56</accession>
    <name>A0A835GD56_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000189">
        <property type="protein sequence ID" value="KAF9412456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD56"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF271">
        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="265" mass="30553" checksum="8D8636A0A13EB525" modified="2021-09-29" version="1">MSMSISTQDSLPQKICFKCIEIVVNAKWLRDKSMSTERHLKSLFLDDEPLILEFSQSEKLKDPTEMKSNSRRSSTDSDRTIKLEIDETQISVTKEEEEDIRPKKRKARGSDSSETLKSSKPDKKISVRKDLFNSPQAPSVTSSTKDVVTSIKQNLKVKIKRIKTSTGDSFYYVCDLCQKKFNAWKKYYLHQKTHNRNIVCPVCEKKFATKGDVEKHVRTHTGERPFACDVCDRRFSQRGSLKSHKISVHQQDLNTLTPEKQESNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDV3</accession>
    <name>A0A835GDV3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000148">
        <property type="protein sequence ID" value="KAF9413883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018795">
        <property type="entry name" value="K2013-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2510039O18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN KIAA2013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10222">
        <property type="entry name" value="DUF2152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="615" mass="69882" checksum="405E1A619AF8D250" modified="2021-09-29" version="1">MSRRAGDVLRRINRLADGPLTRKKLVILVLVVIFLCLYTGPTLMNWLFGAESTTGHQNVCVKNFMKPFETGLNEYDVYVRQESLAAMNSLSHNYVPYVGNGLMGLALEHVPHLNIKHGRTLSLPLNYHPLYVIDDYEIKEFTVAEYKKGIVHRFQCSNSGLQASYQYYAHRTIPSLFVQEIWINNPTSTDKNLRLTTPRVSDWPTSVMQTIKLHQGVDTKEYEVVTGMIPIPDSENVIAAAVVCRKMGNTLRVEARDGLDILILTTVQYSKPIQKSEYASHKDIVEKKAIEEMEKAIALTGDRTAVKKLRENHARVWQGLWYTGFYISDSKAEGIINGDRINATIYAILSQVRSYEHEDNIKASTKSDIMRSLTYSEGCYEGHSTLDAFNLWKPLNSLSNLNTVASIWLLTLEKQGCHNLLKAGASGVNQAMILSFGSLRFSNQHLEYNIHPSKLHRDFLFRRLNYGNMTHVNISVIVQEDNKAAIFVALDRSDKTYYACDAGCLDSPVQLGPYRKYFPVKLTEPLTAILYITADKQHMEDLRHAIHVREVVEAPAHDNHVIALHKHGHSLGGLNPLFWISIIVLIVVFHLFLCRIIMNEFCDNGVSYRRLYNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDW2</accession>
    <name>A0A835GDW2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDW2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="405"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="616" mass="70078" checksum="A76481B71EBBE403" modified="2021-09-29" version="1">MDLFVINRYRDVEENAAVDIAEQEAKHLEKLKKKIAERKSAYASKRTSDVITLKPQKEEVLQKDDTEDNKEAPKIDEEPKTDKITDTIQKPDKKRAKPSQEFKVLGVNDFEKKAKVSRVLPFWLSHPFNISTSLKSSSCKVEDQDWLHITLKSTLQSEGVTTLFPVQEKVVPFILDQHKLTYPFWPHDICVSAPTGSGKTLSFVLPIVQILMTEIGCHIRALVVLPVQELAAQVAKVFKKYCLKTKLKVALLGGSTPLQQEQQTLVRYTESSGWVSEADIVVCTAGRLVEHLQNTEGFSLKYLKFLVIDEADRIMDHIQNDWLYHVDKHIKLENELMTGRHSNLTWSSLIEQKPPPHKLLFSATLSQDPEKLEQWGLFQPKLFSAAKSNSYEDEDQIRLYATPEELTEQYVTCDAEHKPLILYHFLADQKWDKVLCFTNAAEAAHRLSVLLNTWSNGAFKVAELSSALDKSTRESVLKKFTQSEINVLIGTDALARGIDITDCNYVISYDPPRNIKTYIHRVGRTGRAGRSGHAVTILLQNQVTQFKEIIQGGGKAEIPQIEIEADILDRLTSSYQHAMSETKRQIHAEIDSKVKKSLEIKRRLKSKPQKRKPNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDW7</accession>
    <name>A0A835GDW7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDW7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="98" mass="10515" checksum="5518AFD4A9DA8B9E" modified="2021-09-29" version="1">MVITPAGISGPRGLGATAERVACSPVRSPRPCTLHFTERAAFTKSTTAFFVTYCRVPSCDCSSSHRDRVTPRAGDLVETCVSTARALTYDYAVSHDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE43</accession>
    <name>A0A835GE43_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE43"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032343686" evidence="5">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="170" mass="18804" checksum="82E16439F74A78C0" modified="2021-09-29" version="1">MAFVYKLLAPIALATIVLANKAPGGYSYSRFSGPVSGQIVEVQVPAAEGIPAQQHADYGYDHKTGQIHPDTARYAHLKTVDYVAKPDYAYSYGVEDPHTGNLQNHKEHRDGDVVHGEYSLVEPDGSIRLVRYTADPKNGFQATVHKKSSGQPQKLVHYGHPQQEDDSREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEZ6</accession>
    <name>A0A835GEZ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Programmed cell death protein 10 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_007455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PDCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEZ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009652">
        <property type="entry name" value="PDCD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250">
        <property type="entry name" value="TF-1 CELL APOPTOSIS RELATED PROTEIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06840">
        <property type="entry name" value="PDC10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 10 dimerisation" evidence="12">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9414677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="203" mass="23111" checksum="E087279B15A3ED26" modified="2021-09-29" version="1">MTMGDELPVTSLVLPVLIRPVLTQLEKYDLGASQTLRAALTKAEAAVPGLNYDLVAGIMRRADIPVNMNESLLRLQGTLTEAECADLRLNRTEEAFQELNKKSTALKKILSRIPDEITDRKTFLETIKYVCTGKQVLEQRKREFVKYSKRFSNTLKEYFKEGQANAVFVSALYLIHQTNQILYTVKNKITTCPRFIDSNSFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF07</accession>
    <name>A0A835GF07_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HW555_007470</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">BAW_Kor-Di-RS1</strain>
            <tissue evidence="24">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF07"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04122">
        <property type="entry name" value="Rab14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000344">
        <property type="entry name" value="Ras-related protein Rab-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030702">
        <property type="entry name" value="Rab14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF9414692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="23649" checksum="732A9DF7A05F39DB" modified="2021-09-29" version="1">MTSGPYNYSYIFKYIIIGDMGVGKSCLLHQFTDKKFMADCPHTIGVEFGTRIIEVAGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDTRNLTNPSTVIFLIGNKSDLDGQRDVTYEEAKQFADENGLMFVEASAKTGQNVEEAFLETAKKIYQSIQDGRLDLNAAESGVQHKPASPGRPLAAPPAARDNCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF11</accession>
    <name>A0A835GF11_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF11"/>
    <dbReference type="OrthoDB" id="6475149at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032728553" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17568" checksum="46DCF75AE0647785" modified="2021-09-29" version="1">MWRTVLGFSFFFYTIVSHVTTAPMYYQNQNNRGPSYTISNVPEGPHKPYIEVRNSTYHGSGPREEARAMCSVRTQEVNATANATITRRLHGVVTSRELHNSIQRLEVIIYGQMQQLWQSLDALRTQLSGNARSSNIMFPPRNTVSFRYQPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF36</accession>
    <name>A0A835GF36_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbonic anhydrase</fullName>
            <ecNumber evidence="8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_011365</name>
        <name evidence="9" type="ORF">HW555_007043</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000121">
        <property type="protein sequence ID" value="KAH9643584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF36"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000007">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9643584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="254" mass="29722" checksum="8091A3F2AA06DAE5" modified="2021-09-29" version="1">MEKILRGIMRYRVLDRASMVKQFQEVKNNPTPKAVFYTCMDSRMIPTRFTETSVGDMFVVRNAGNVVPHSQYFVDEMTSCEPAALELGCILNDIRHIIVCGHSDCKAMNLLYKLKSKEESSIEQRRLSPLKSWLCSHAHTSLKKFIEMNNDFTKPMLFTGETPQRKFVAYIDPDNKFCIEDKLSQVNTLQQLQNVASYGMLKKRLEKHDLHIHALWFDIYTGDIYYFSRRAKRFIIIDESSYESILAEVRRFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFG9</accession>
    <name>A0A835GFG9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFG9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="34912" checksum="A3A00314BBBD03E2" modified="2021-09-29" version="1">MSDVDKWIEIAKRCKYLPEDDLRELCNIVCDFLLEEPNVQPVQTPVTVCGDIHGQFYDLEELFHIGGQVPHTKYIFMGDYVDRGYYSLETLTLLMALKARYPDRIILLRGNHETCQITKVYGFYDECLNKYGNANAWKDCCRVFDLLTVAALIDETVLCVHGGLSPDISMLDQIRCIDRNQQIPHKGAFCDLLWSDPADVNMWSVSPRGAGWLFGSYVTELFMNYNNLNLICRAHQLVNEGFKYMFDKRLVTVWSAPNYCYRCGNVASILEFNTVNDRVPKLFQAVPDSEREVPPQHTTPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFJ3</accession>
    <name>A0A835GFJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome-b5 reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFJ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63441" checksum="09F43C813F76AD48" modified="2021-09-29" version="1">MIDRQAGAVVNKLVCTLHADIRAGNPRNKCALQPGHSLMDWIRLGNSGKDLTGVGGRIRPVTPAELSTHNTTNDAWLAIRGRVYNITHYLPYHPGGPEELMRGAGMDATQLFDKVHPWVNYDSLLAKCLVGPLRFDLPDADELFDTSNPSPKSDRLREPSKAQELVRKSMENLANCITPVRKKITKGDDNSKGSPPSKIMQSLVQSADLPMSISRRAASSPVKKTDKSPDSPLPLRHDWIQTSTKLTISVYTGHLANPGGCARITEGFLLIEVATNGWLRTLKIKPEAKLKEPLQLRVFAESGKIEITALKVEPSVWKGCGEVTLGAASRVSSPRTVECRVMEVSRVSHDTSLLSVCPRAGPVVVPLGHHVRVHRRVEGSECVRSYTPVGEGWGPPDGTEIFSALRLAVKRYDSGVLSPHLTALKVGDLITLSGPYGNFQLQKLKTVKTLYLIAAGTGITPMLGLIKFMMSSERTHLLFFNKTEADILFRETFEEMVKEDERLKITHVLSDASSSWSGHKGRIRDELLTDILKDVKCDDKCSHYACLCGPTEFTYAGLDLLKKHGFKDDCIHAFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGE3</accession>
    <name>A0A835GGE3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGE3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="493" mass="56323" checksum="AAAB70D6D141D91C" modified="2021-09-29" version="1">MAVWFTLKIHLTIMDLTDQVEDGCVNLDIKVIVIGFTIVEHKFEGPAISRLASILYFESLRNKTFTCQRRARTGGQAWQAAGYRTRFVEKSAPSRLRRHHSDPLHIPLFTIHHCTGTIPWNVSQPLRNKLRFLRLDSTLILNRHARVHPRFLQIHLISNAVYYCVRISRYRNRQSDNPFAYSVSDMQIIIYNNFELYNNAIETMSDVNTICRQRLLNVLIKFDGLTTSYVHRNDSRKSSCNVTAAILENELKAVVTSLASTLQWCATEGHAWLLHLMCYGLPPAMVQDGRGKKLRLMNLRNPPGWSYQIYIAILTLPRMLQRSAWMRVLPLLVSISISMENTHSLTHRECIHARSCGSRDTRGETCTPARRCGARRKYCTTDANRARAAVRESTKRNYARECAKNPHDDADLHSRRNARSWLPPAAHGCQGWRGKRGGGRQGCKISRTGNGSRAPVHTPIARGYEPSGMALQSSPTGIRLLMNMSFQHRMRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH18</accession>
    <name>A0A835GH18_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="3">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45914" checksum="DE89FB44B1285B0A" modified="2021-09-29" version="1">MKKSTLKTDTPSHCKELPKESPRQRGGILSCLNVTRQTELTERERGRRRKKGIIRLRNKIKNKKACIQHLAEDEILHKLCNLNIKSVKKLPKKPKVITKQKMTFLCILSFDEMSIRKHLSYNESQDEIQGFQDHGNHGRNHQIAIKALVFMLAGIRKKSKQPIALYFSHTMNSDRMTVVLKEILTECFNSNMNVVATVCDLSTVNMKVLKTMGATTRDPYFSHNNNEIVAVCIAKWSYKESFYNLDKSNPNFVFAPALTESHIKPNVKQQMRVKLAAKIFSHSVTAGILAKISSNELPPEAHATATFTKKFDDLFDAVNADSPDLRRGKIYSTNITTRSPHISLFNKMRKFISNMKYLGSRSTPPSQHGWIHTLNAIERLWKNLQAKQIKSLSTRRTEGPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHD9</accession>
    <name>A0A835GHD9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADPH oxidase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_006739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHD9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000056">
        <property type="entry name" value="NADPH oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000258">
        <property type="entry name" value="NADPH oxidase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000012">
        <property type="entry name" value="NADPH oxidase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF58">
        <property type="entry name" value="NADPH OXIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="322"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9415705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="97220" checksum="41D5C81A16281A0B" modified="2021-09-29" version="1">MEFLSTVTSSRPRVGFDKHSVDRLEKLFRATVGDEKEITREQFQKIVVSKNPFFTERVFQIFDEDDSGAISLQEFIAAVHQFAGQTPEDKIRFLFKVYDLDGDGLIQHRELQHVMRACMEENGMQFSDDQLLELTTAMFDDADTERRGAITYDALKKQLESHDGLLENLSISIDRWLVPPKQDPEPVSFKQRLSRLKPYQLSRPYFKNNYVFLTYLALFTLVNVGLFVARCVEYRKANGFVIFARACGIIVVNDPVLNKANYTLSEWLLTEKPGLFGLVPGCANPTGIALAVILLVMFICSQPFIRRGGSFEWFVLPGTVYLSERIMRLAWMRSERGKTYISSGILLPSRVTHLVVKRPPLFHFHAGDYVFVNIPAIATYEWHPFTISSAPEQEEYIWLHIRGVGEWTNRLYSYFEREQARLHGEELPAIENGHQKLARSISSQSKKSRKGSVGSTKKRSVDFSPKCFTNEAYVAEEGNGDVKQNEAQSPTKISYHPSLLLAPPRTLEKSRSMPDVQKNLKKRQRLMALRDFMRSESESKLDEGSILSARKTFGLASKIPQNKSLVHSFRYMRTKPTIIAFKTPSFEERRRSNDSILTLARRRLSKSLSPDRDIECQPEKIVECENDGSEATDDFEVNYPIGKPLEIYLDGPYGAASSHIFLAQHAALVAAGIGVTPFASILQAVMYRYWSARQDCPKCGHTWASDMPRHNMNLKKVDFFWINREQRSFEWFVSLLSQLEIEQAELGGAMERFLEMHMYITSALQKSDMKAVGLQLALDLLHEKEKRDLITGLKTRTNAGRPNWDKVFKQLQEQNKGKVTVFYCGPPQLAKILRVKCDQFGFGFRKEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI16</accession>
    <name>A0A835GI16_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bromodomain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI16"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="415"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="617"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1222" mass="135301" checksum="0680CCCFF8A1BCF3" modified="2021-09-29" version="1">MQQTLVILGSCLAAMSEVRCVFGGRVVLLFNAKECSRTFLRSPKRHAAMYIADDSFGQFEESHFSPFQKLDLVDGGSEVKTLLCNQRLVLQYQYFPTLQSDASTMQQAVDPLATTSTPTAEPVNGAPPDEPARRQGRMTNQLQFLQKNVMKAVWKHQFAWPFHQPVDAKKLNLPDYHKIIKKPMDLGTIKKRLESNYYYSAQECIQDFNTMFTNCYVYNKPGEDVVVMAQTLEKLFLNRIAQMDKEEKEIETPSKGGKGGVKKRGTSTPGAVGAVATQPSSFHVTPPAAPPVSTIPAVALSQTQPAKRTVRNMYLQYFIIREKPILLLLWEVLLKEDTLHQQLINKVVPNLQRFPLGERASRTGDDGFKMGGLSPSGAGASHHSAMTPQLAKSKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAELLGLHDYFDIIKKPMDLGTVKQKMDNRAYKTATEFAADVRLIFTNCYKYNPPDHDVVAMARKLQDVFEMRYAKIPDEPVHVGVPHMDKGSSASSSESGSESDSESDDSEEERNNKVKLLEKELLALQEKMRKLTLAPSNVRGKTGTKRGGGGGAAGGKAGARAAAPGKKKSSTPTAAPPPHVPPHPDTDDEDQAKPMSYDEKRQLSLDINKLPGDKLGKVVHIIQSREPSLRDSNPDEIEIDFETLKPSTLRELENYVASCLRKKTHRKVSGKSKDEQIAEKKQELEKRLQDVSGQLGTNKKQQQKKAEGCKEALGGGMSSSSSSSDSSNSSSSTDTSSSDSSDSEAGTGSSRTPKKKPKKQHQHPPQAHKSVAPVTVATTLAAPVSVPTTVEMVAPAPPVDVKPAIVPQEVVPAQPLEHKEPAPIPTPVLSVPTSVPQPPTNIIPDSSITPVVRDIEDQKPIPKIEPRNGLDKIDGSQYIDPIERSLASLERNTSMRLEEEFSLPKPQIMPDAAHQNLMAQLGGLAEVARVPEQIKTEMFMPPHNGFVDKLQHEREMLRPDINPIIPGMTGVPQVTSIFDPIPTAQHSVISQSHLTMPNAPCLITPAAKKEDVKPLLTPKPIEDLMGIPNMVSNNMSDRVKYEMEKKMEDSKNTNFAQAFKLKQEQNLKNASSWSSLAQAGSPQSIPNMGPNHQIKQKPVMDSFQAFKKQAKEKIDRQRALIEQQELRKKEQAERERQRQETERRQPDEEKMRQVLQTLKKSLRVAQGVRKVESAEVASPHGGSDRHEYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI41</accession>
    <name>A0A835GI41_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_000147</name>
        <name evidence="4" type="ORF">HW555_006386</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000779">
        <property type="protein sequence ID" value="KAH9631104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI41"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02429">
        <property type="entry name" value="PTH2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9631104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14381" checksum="635DE825D9C0F707" modified="2021-09-29" version="1">MSNTIVQYILLRTDLLKELGWSIGSVVAQACHASTAVLHLYKDDETTIKYLDDMDNMHKVVLEVPNEEALKKLAEKLKENFISHKLWIEQPENIPTCIALKPYPKEEVKKFVGKYKLLKLQINGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIA4</accession>
    <name>A0A835GIA4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="228" mass="24594" checksum="187927B284138004" modified="2021-09-29" version="1">MCFPESSYSAVNFDIVARGFRSTAGFVEDTQVGADLVDTTPPFLRQNIDVFFFPSPFLGNTCAGMCSSSCSTFGSAHECEGGGKEWWGAHHVDPLQPLRIILHKLANIIERRTCEGAMFVEVSEASPCQAVRLQLGASAVQVHATSSHEQLQDAFTSMQYLPTFSGWGRYGEAASMLRRSCTPRSISPGVSPSSCAMSSACLRDGPCRSAIALHNTCLLVPRNADSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIY8</accession>
    <name>A0A835GIY8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tailless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000019">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="132"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9416016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42492" checksum="21A49E02B1230E84" modified="2021-09-29" version="1">MHGRILYDVPCAVCSDHSSGKHYGVFACDGCAGFFKRSVRRDRRYSCKARNPGGCLVDKAHRNQCRACRLDKCLQVGMNKNAVQHERGPRNSTIRRQMALFLKDPPPGSEVPVPGPPPLNLALPKHNLVAPPPVPLYNPYNYPPMGIFNTPVTSMLAMPPSPPMLNPAMFRPSDPSTICESAARLLFMNVKWSRNIPAFANLSMEDRLALLENSWKNLFILGAAQFLHPMDLNMLVDRNISIVVNKKEIDIFEKSLEEISKLNPDANEYACLRAIMLFNSRLDKEGDSSPNRTSSENKKLQDVAAVALLEEHSTLMLNEYCLRVYPLQLRRSSRLMSLIPIIRNVPSFTIVELFFRATVGDIPIERILADMYTNGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJA6</accession>
    <name>A0A835GJA6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJA6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF144">
        <property type="entry name" value="SPINDLE AND KINETOCHORE ASSOCIATED COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="192" mass="22110" checksum="0E62C6FDBE5B5C05" modified="2021-09-29" version="1">MTKFLRPFVVELDKDMIKKNLPMAFRHKYNNVSCIIDCLEIEMQKPSKAVSQAMTWSDYKKANTIKYLISSTPNGLDLGAEHQSCDFIKTLKNGMVVMTGRRFKHVEQYLKKSNNTLVRPASVEAGVKMSKCEAKLTKQIATLRIHIKRVIRRLRKFYMLKPHACLNLKVIKILDDIIIIACALINLHDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJW9</accession>
    <name>A0A835GJW9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">10-formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="2">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000008">
        <property type="entry name" value="Cytosolic 10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011407">
        <property type="entry name" value="10_FTHF_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036489">
        <property type="entry name" value="10-FTHFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="1 2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="329"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="638"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="658"/>
            <end position="659"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="812"/>
            <end position="814"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="910" mass="100363" checksum="8C92F2712EC75FCA" modified="2021-09-29" version="1">MPPVSLTSDAPKKKLRVAIIGQSLFAAEVFKLLQKDGHEVVGVFTVLDKGNREDPLATIAAQNGKPVYKYKTWRVKGQVIPEVLEQYKSVNADINVLPFCTQFIPMEVITYPKYESICYHPSILPRHRGASSINWTLIEGDTTCGLSIFWADDGLDTGPILLQKSFPCTIDDTVDTIYNKYLYPEGIKALAEAVNMVANDTAPRVKQTEEGATYDPALFKPETHKDSSPGATSFIKPQTKDGVVEDSEATIEVKFFGSSLWVDEYETKGDALVIPGLSKPAVVHEAGLLITANDGVKLNIQRLKVNGKMIAAQNFFKANEDKVTLELTAEEKQFVENVRDIWKAILRIDIDDDTDFFTSGAGSMDVVRLVEEVKDLAKLELQNEDIYMNTIFEEFYTVAILKSRGGTENAEISYDGVEMECNKMKIKFPTQLFIDGKFVNSDNGKTLTLINPTDESVICKVQSASVNDVDRAVLAAKKAFEEGEWSKISARERGQLLFKLADLMEQHKEELATIESIDSGAVYTLALKTHVGMSIETWRYFAGWCDKIQGATIPINHARPNRNLAMTKKEPIGVCGLITPWNYPLMMLSWKMAACLAAGNTVVMKPAGVCPLTALKFAELSVRAGIPAGVINIIPGSGTVAGQALADHPLVRKLGFTGSTEIGQTIMKSCAASNMKKVSLELGGKSPLVIFEDCDLDKAVRNGMASVFFNKGENCIAAGRLFVEETIHDEFVRRVVAETKKMTIGDPLHRGTAHGPQNHKAHMDKLIQFVQRGVKEGATLVLGGKRVDRPGYFFEPTVFTDVQDDMWIAKEESFGPIMIISKFSSKNMDDVIRRANNTEYGLASGVFTRDVSRALQFAERIDAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGQEALNEYLKTKNITIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK91</accession>
    <name>A0A835GK91_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK91"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF1">
        <property type="entry name" value="RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA methyltransferase bin3 C-terminal" evidence="2">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="146" mass="16796" checksum="2033CB696F304BC9" modified="2021-09-29" version="1">MITCGQQDRVSDVGCNTGDLSKALYTYLKTVYPYCDIHMLAVDIDSTLIERAKEANENPYIKFMTCNIMEQNDQLLIQITMWIHLNNGDAGLLAFLKYLKAIVIEPQPWKCYRNAQRRVKKSGNSFELYECLKIKSDVDLAFWAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL39</accession>
    <name>A0A835GL39_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL39"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029686">
        <property type="entry name" value="Malpha/m4/m2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254:SF0">
        <property type="entry name" value="BARBU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254">
        <property type="entry name" value="ENHANCER OF SPLIT MALPHA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15952">
        <property type="entry name" value="ESM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="25472" checksum="AE0894ECCFE3BBFB" modified="2021-09-29" version="1">MHIGVSNKPLDSPTHTKGAFHVLVDLLCRGRRAHYKSPTGSLSPTFPPVISLATHALSTITIYLSNFDMSYYANNEYIIATNNSINENRYNSEKMKNSGIKALLRPLMKMIKKTTKRAPAKTCDTCFEEDQNSSNEMLERKICEEMEACQSGAAFLVYNDNNTCDLVPVTPDNFYVPVHFARTEAGTFFWTTVSKTEADFAAAHCYTECQTAEQQYPVLQDRWVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL78</accession>
    <name>A0A835GL78_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="586" mass="68027" checksum="02A15B07E494B76D" modified="2021-09-29" version="1">MEVVGVCRCCLTQGLNKDLHSIYHWLDKKEIYAEMLLECFNIVLTPSNIKPAGICEECIKSLRSCVDFKQQVLQADEEFSKKLQSMEIEDENKTSEIMISLSTKIVEVKVEPKVECDDDDDSDDYYLADAVRNSPPNKIESESVPVKKKTETKRAKPKSSPKKTKATSEGAWKNDKIKSLVSRLATSIKSCEMPDIKPGKKLEIKTKKRLDLTVPRETKINLLWTGQPHHDKHKHKQNLQTILKFSNATPFTNKTLLGYSCGYCERSFPDPADLRLHTETEHAKERLDFKSNFDMREYNVKIDVADLTCTLCHEKMDNLTVFKDHVTKEHGITIYTDIKDHILQFKLKKGEVYDCVMCSSTYETFKMLKQHMNKHYSNYTCSLCDATFATKRSLNAHRTTHQDGSFKCDHCDKVFASRTKKHYHEKMKHLGARNISNCPYCNVSFRSYYQRNQHLVKVHNNEAQYKCNVCSKSYILKSLLMYHIKKSHLMERNCQCTECGYRFFSKKALKAHMVKHTGERIYTCEVCHKSYARKYTLREHMRIHNNDRRFKCEVCSMTFVQKCSLKSHLLSNHGISMAASEIVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLX1</accession>
    <name>A0A835GLX1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004306</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLX1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000051">
        <property type="entry name" value="Transcription factor Sox-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="180" mass="21026" checksum="5DBA5D3E249632D0" modified="2021-09-29" version="1">MTSGACMRRTHVKRPMNAFMVFAQAMRRRLSERRPTLHNAELSKSLGTMWKGLSESEKLPFIREADKLRTQHKKEYPDYKYQPRRRKPQPTSAVRPKREPSPERDQIDFAAMPDISRELLPDGPPDNAELEQYLIKPVPDYHELQPRYPHSLQHPPPPIYGPPHLHHPYGADWSPYPGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMA3</accession>
    <name>A0A835GMA3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cubilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_002423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="CDD" id="cd22201">
        <property type="entry name" value="cubilin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000060">
        <property type="entry name" value="Cubilin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000260">
        <property type="entry name" value="Notch receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032431391" description="Cubilin" evidence="12">
        <location>
            <begin position="22"/>
            <end position="3714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="3529"/>
            <end position="3551"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="490"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="608"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="727"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="840"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="960"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1163"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1277"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1402"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1516"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1637"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1759"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1870"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1997"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2162"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2280"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2410"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2644"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2756"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2870"/>
            <end position="2982"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="2984"/>
            <end position="3096"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="3103"/>
            <end position="3229"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="3233"/>
            <end position="3389"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="3392"/>
            <end position="3536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9421742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3714" mass="412547" checksum="D5CCA843123810C8" modified="2021-09-29" version="1">MTSTLGKWLLLAVLCFVPLDGEIYQDRPKIKTSGGDLILEPALDKNIYLRPNGPKSNIFIGDVNILKTKLSDDGTQYQPANNDIPVNSLNGILQRLDKLENKNTALPSDLLFNITLIWRRVNNIHRKVLSLQSQLESRNRDQCESNPCEHGGTCLNLANGYHCLCPPNWEGRDCDVDVNECRNFAGTDLGCQNGATCYNTPGSYQCFCKSGWFGMHCTRKAKDCSGGDFEMCGHGTCIPVTTGEGIQCICHQGWTTNSTGIACLTDVNECESYQGPRCSVNPKVDCINLPGSFRCGQCPAGYEGDGYSCYDIDECTTIPNGGCSPLVTCHNTIGSRICSPCPPGYQGDGVTCSWRGTCSINHGGCHPSAQCVESASPTGQSAQCICPDGMEGDGVGISGCYVAPGGNYTDCAMNPCGVHGTCHSLRTGYTCICYKGYGGAHCELATDACGVNPCHNGGICRPDDSAIGGFRCECAARFSGTLCQVRAKSCGGVLDNEEGSIVYPLTNTTYNHNSQCAWVIHTAPDKVINVTFSKFNLEASPECAYDFLQIHDGRKSASQLIGRFCGNNYPNGGNIVSSHNNLYFWFHSDKTVAKDGFALHWTSIKPVCGGEVDATSHGHISSPGSPGPYPPDRDCYWHLTTTLGKRISLHFFALDIESHTNCSFDYLALYDGEHTSDPLINKYCNSTQPAPVQSAGSDMLIHFHSDAYGAGRGFQIVYAPVEGIPGCGGYYTAAKGELVSPTYDGRYLSNLLCEFKIKTSEDTKIKIEFKSFKLERSFRCSYDYLKIYDGPSADSRLVGKFCGTTYPKSYVSSSNTLYFVFKTDRSMPSDGFRITYEAICEKTIEGDSGVIKSPGYPFSYPNNKVCVYIIRTVPGKAIQLTFQDFDIEDNRYNGCRYDNVEVRDGHDQNSTLLGRYCGGAAHTPPTQTSTLNYMYIKFTSDLSLSGTGFYANYTTIDTECGGVYRETTGLINHPSADSSDTAYKNYQTCQWLLLAPEGMHIKLSWNRFDLEDMPSCASDYLKLLEIDDNNERNLLGKFCGSKSPPALTTSTNRLELKFVSDGSIRYAGFSVSYTFLDEKSHCGGAYIKSHGFIYSPGWPKQYEPNRDCTWTITVPAGQQIVLNISQFNLERPIRDRCNLGDYLEIRNGGSGFKIEWDGTVTGCGGTLTSPSGTVTSPNYPNEYTENAECFYRIVTSEGSRIHIAFTELDLERTPGCRDDYIEIFDGRDTSANILGKHCFMTPELSNIQTSSNYAYIKFRSDIFQGGKGFLFNYNTVCNNNVTGRYGVIESPGFPGNCPLNTNCLWTINVPKGNTINVTFTHFDIQKWFRFYRPWMRARNQDECTTDYLQIKDIADPNYSNKFCGRTSPGVITTKGNSLQIKLVTGINTIRTAFRLEWISSGCGGYIKKDMGTIELDKSVTNDKELECEWLIEAQMGKSITITFSEIYMSDTANCTVDAIEVYNGQNTNTPLLTKICHRDMVSVSSDSNFMLVRLSKRSTLRDVHFSSQFRTSNSKCGGIQNTKSGGIASKNYPKNYDNNLDCLWFISVPQGHRIEFNILDLDLYSLREFGNNEVQCGDSIQIYDYDNYSPSLNYTYRICPKSNLTQIISTYSNLFVQFKTNGYGTAKGFKANFTMTCGALIKTKDDGIIQSDNFIRHTNKSCIWTILADSPDQKISLTITLLSIPKDNNVITNRTCPSSYLRVLDGDDKYAPLIGEYCGRKVPPMIVSRGSAVTVEYGSYTGAPTGMFSAHYSALSNACGGTLKSEEGTIASPNYPGPYPINSDCEWILQASPGNTAYVQFEQFDLEYSEGCNDDYVELRETNGAGRLLGVYCSSDTPTNHSSASQIYIKFHSNSKTSGRGFVLHYGFQRENDITGDNGEIASPLYPSPYLGTGEYSWRVLTSDSATISITIDDLEIYTHSQVNYNKLTIYDGYDLTAPILQELNGVLAERKVIQSSSSVVFITLTTDESNTGSKFHLSWTKSFGNYDVEAGDSINCGSNVTKLVVPGQTESISSPNYPLDYSNNLNCEWVFKSEMGRHLEIQFVDFDIEDTHACFADAVSVYSSDTPGNWQSVHDDICNSETVRAGFNTSTYMKIKFKTDSSITRKGFLARVNSQCGGLMTALSGHIKPTWLDVQTRYRYTKGSFAFQSFTIYYEEQNFECGSTTTLTTDHGWEVINSPNYPQVPVPYSECEWVFTAPPGEILRIDFIDRFDLADDEDCEKEAVEVRLGSSKYSPLNGKYCSDKPGTIKSTGNTIYIKYSTSLAEPQNGFKANVSIDTCGGTIVSDAGEIKSPGYPHLQVFPYGTVCEWRVIGRPRHVFQIKAEDIQLPDTELNCGTKVTIEESVPANNTITVIKTICNDDGTIYDESLIQTSRNEFTIKLHIGKPDTWEQTSNNRGFRISFNSSVPMCGGPVTASEGYLTSPSYPQETTIRYCQWLIKVPDKSRKVRLELLDTDMEKHRIGIFNDIAFHTLIQTIPSDDYVPGTTVFESSGNKMALYVWLNRTAVTHRFKARFTSDEKGLCGGDLSGMNQILDSPELNQSYSCEWHYNGQVNTDDTVTTNTSYNSIFFTANLSSSVTRTGGRCRFFDPQIIIKTGIRNRFIRNICGNTQTSFIIPSPVMDITAIKSKSSSFSFHLDWKGQPCGGTIKVGEDPVNILQIPDSYNDPINCAWIIEGSTNRVEIKTEGSFKLDCDDESVKIRPSLSQNAPVIGDYCKSKVLETPLITHFSNVYIQYQKKANVSTSLRLMVRSVTNQCGGFLSSYQNSFVSPNYPKNYSPNQECPWEIQVDLGFRISLRFVERFVIEDRVNCTKDAVIIYDWKDNEYQQIARVCGRQTPPPYNSTYNRMKVVLRTDADTNLDGFKATWDSICGGNYVATKKEQILYSPGFPYGYHPSMSCKYEITAPGGRVVIKFLEFELEGTFPDCRSDNVTVSSQSDYSYTYEIYCGSKIPPVFTLSEKVTLEFNSDRYIQRKGFRISYFIFECGGKVNESTILSSSLSDTYDQNMNCTWFIEAPPTKIVVLKFPYIDVESNTDCYSDYVAVFEGSKIDTDNRLAMLCGHINTTTTLRSRGNKMLLQFVSDMSVSYRGFKAQVYFSYSEAAQCGGQINLTTGSSHVLKSPLMGHPVYENYLDCFWTITSPPDTVIKIDFTSFHVSPCQNVNQTAIGYSKCDCDFVEIRDGINPNSLVIGTYCGHTLPPQLSSSSNIMGVTLSTDSEIGSQGFVATLTVQPSVCGPSVITVSHTPKRLKSPGYDAGSIPRGLHCLYHLDNSESPYSYIILTIKDLDLQPAVTDSANVTRCNRDKLFISTSPNNPNVTIGKDFIINYQGSDIISRNSFFDSALYIPQIYEFCGRKEPSDLYLNGATKLNIITSSESDSNVHKGVEMEVVFAGFCGRNYTEPYGRVQAAYAGYSDTTLSDCYTLITAPDNYTISAYIFNAAPDYWNENSYVDVFDGKDSNAPKLVRIATSYEGNKPIFSTGITCDQNYVQLVDSNGEVVRTFCEEMPADYTSNNNYVKIVFVTTMNNGGTGWVAEFIAAAIALLTTICIIIYLVTSPYPEMERFEEEKTYNDPRSKKRVAFPNIEDPHSVHLSVVVPAYNEEERLPPMLDEAIEFLESRVKEHHSYKYEIIVVSDGSKDKTVQVAEGYSEKYGCEKIRCLELIKNRGKGGAVRLGIESCRGASILFADADGASKFEDLTKLETALKELCYDPNTSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNE5</accession>
    <name>A0A835GNE5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNE5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="160" mass="18716" checksum="1E55C9BB7A214A54" modified="2021-09-29" version="1">MDDIETITDNLKIISLVNDTADRLLLNEKKSTEDLDAQTRRAIPALEYQPQSRIKGKLLSYLEETFDEIDRKIKPLTNIKIALSNNNEYRIGYIIATIDTMQVNLKKWKENTRVNQHKWNDEKILDVFDRIKATNKVTSNLIETLKRHLSEGKETKVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNT9</accession>
    <name>A0A835GNT9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNT9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="121" mass="13287" checksum="A847C7471B371809" modified="2021-09-29" version="1">MQRACVVDSSVGENTAHRKCDIVAATATFLTGSVIDSELTNDDWKILRRDRVNGTGGGVILLTRPGVGAVRRVDLETSDGEDLWAQIITDYDTIYVCVMYTIFIQERLKKSTCGGSKKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA2</accession>
    <name>A0A835GPA2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="22673" checksum="304440F458C4FA3A" modified="2021-09-29" version="1">MVLRNKDQWTKYEEHRLLKKSLEECWANVARGDVAGTSAVHNDIHVTKNVYIQDTKSGLGQSVTKCKLLGLKFEGESAGLEEWITRSEEAGRSFVHHCSIFNLHIQKNNTYPASGSKACVSRPGSNELSWKACAADQTPSLFYREQQIFSCHGSKRQTSFVSKGKNLSTKVDQPLLPQPQLLASVCMFFAADHTAWPRPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPT5</accession>
    <name>A0A835GPT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="31606" checksum="94EE23AE0C3E0AA4" modified="2021-09-29" version="1">MSRRNRLRTSFGNEVHQGAWPHHVLIFRLYNKLKFQYRAFCAGSIIGEKRVLTSTNCFFTNRKNPRHKFDQVRFVAGILKTRGTEPIHDDIEQWRKLERVYTQKFYRFPAFNLAVVVLTKPWVFNTYVNKIPYATKEQDFDGVCTATAVKATRSWSTIKYLYTQEVEMVPREECEKILCRSCRLFMCTVFNNRNQYAYSETEGGGLVCYETGDPAEVDINQGVLVAVTSIVNIGLPNLNMRVGLFSQWVTDVSCDVYVNKFVMVLCILMLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQU6</accession>
    <name>A0A835GQU6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="64" mass="7569" checksum="10EC531269B347CA" modified="2021-09-29" version="1">MVFCKQYARITEKWQMNLADHPITQTPRAPHVDVWTVRIKPRSNITQIAIAQRLHPLPQAQYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTC7</accession>
    <name>A0A835GTC7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTC7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF44">
        <property type="entry name" value="ODORANT RECEPTOR 13A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="353" mass="40799" checksum="D2B7B3446A299F1D" modified="2021-09-29" version="1">MENIPTYKDFHKQIKINLWLAGIPYGDPKIYFRFFVISIQLLLMIIFEISFFVSRISPENFLELTQLAPCIGIGILSLLKIIAVAQKREKIYVLTESLEKLYNKILSSEKKVKLVRKDLVVVNLLMKYYFILNLVLISVYNFSTPFIILYHYFAKHEVMYILPYAVLVPFSTDSWLPWTVVYIHSIMCGFICVLFYTTTDGLYIVLTSHVCANFSVISDFIESLDETTADRLADIIKDHQYILKLGEDLEDIFTAPNLFNVLVGSLEICALGFNLTSTKIGDAAFLCKWYKMDEKSKKTILTIMIRSKKPQQLTAYKFSTISYASFTKIISTSWSYFTILRTVYSPPEVTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTX9</accession>
    <name>A0A835GTX9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Salivary secreted peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTX9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032615843" description="Salivary secreted peptide" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10640" checksum="30074A11AD084FE6" modified="2021-09-29" version="1">MSFKVNRLSAFFFVCLIGSIHSARIKRDDGDESTAPSEPATSESPQPGSSSSTRSPLDVSSIFENLGQIFPGNNNSPNWIQDASAWFNNWPNWFGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTY4</accession>
    <name>A0A835GTY4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTY4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="186" mass="20909" checksum="B7E13F500E661170" modified="2021-09-29" version="1">MYEIPSVSSMTPEELRHKRKALRDAIVCVGWIKILSIVCYISIFMMIYEYSKGPWSTAIQVMVLAVIPMQIVNGLLLFWGATEEKISALELAVWLCITVAAYNTILSLVGGIFFIRTGFLLIHFLMAIMFALLSVSVFTVLCHDVIVIYTFKTLTKSPSTLTQPVETMIPPPNVLIKNVNIKPPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUA0</accession>
    <name>A0A835GUA0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSMD12/CSN4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="627" mass="72433" checksum="FFF9DE8FD543B213" modified="2021-09-29" version="1">MCTDTDTDSERPPNRIEIDFRSTCYEKIPLWKSWAAKGRVQEAINQLLFLEKQTRAHTSVPDVTARILVAIVQIYFEAKNWLALNEQILVLARKRSQPKEAVLKMVQECITFVDKIPDKANKMKLIETLSFVTEGKAYLKEETALLIRILNKINNEDEQNQIETPSVSDRSVPLNFMDPADIEIPKKRKILDRHSKEILFNLHKYFNGLKNKDMSSIYQTSAAKLTSDATGVPFSSVKKVIFESKRVLEEGKPFTSSKKLLVARKNKVNINDFDRAAIRQVIIDYYYEYYNEDKDFPIMTTLHESVKKKLNYPGSVATLRREVTRLGFQWKMTEGNSGILVEKHKIRFQRINFLTKIAEYRSQGRPIVFASEVYMDTSISSNPSTRGNGLIIVHAGGSEGFVPNALAMFETNDPVGTRPHYLSTEDFIKWIENDLMPNLKPKSVVVIDNVFYQNILEHPAPGPHACKQEMLDWLDFRNIVHSSSMLKPQLYQLILEHKKNFKEFKIDYILRKNNHSVLRLPQYHPELNPFKKTWLIIKQKMGKRTEWCKQGKNITKFVKSKINSIDVQEWKSACDQAVREERKYIGHEAAIDALTERLEKKVCDSSEESDADNDIIMGEAESDVEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GV25</accession>
    <name>A0A835GV25_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor-type tyrosine-protein phosphatase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GV25"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000070">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="309"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="500"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="70771" checksum="A789C6F23C3D9C0B" modified="2021-09-29" version="1" fragment="single">DENGSISETIPDRPVDLKNFPKLCDQRRKYPVLYKLEFQTAVKVETHSCRHATKKTNSHKNQNQKVIPYDYNRVVLDTVDREPDSDYINASYIDSILKPNAYIVTQGPTEDTVVDFWRMIWQERAAAIVMLTKTFDFIKVMCVQYWPPNKEKDETYGDISVGIVVVEERFILQFHYTQWHSHTCPFSNALLEFRRRVRAVVGRRLATNPAAGPMVVHCNDGGGRSGVYLAIDANLELAEEEDCFDVFGFLKKLRQSRKGLIENEEQYKFVYDTLEEHVVCGVSWFPVSELSQRLKQKSQRDPVSKLNEYQKEYQQICKQTPRFTIGDCAGGHRGDNREKNRDVLVVPPDNFRPYLTSFQGNSFTDYINAVFVDGYTKPREYIVTEWPLVRTQGEFWSLVYDYECAAVVVLCVPPKNSQQFPPFWPEGRHSKKYGPVFTIDHVSHNHYTNIKTWIFRINKKIISLTELMAGVKAPTKTVQLFQLTCWPMGHKVPSSTNSLVELMNMVERWRQRTDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMVCINHEIINFANVDKCTEYKYCYDLVLHYVLHYLNKDMNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVL5</accession>
    <name>A0A835GVL5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="293" mass="33804" checksum="5C8E7EF2EC1657C4" modified="2021-09-29" version="1">MIKANIRAAKRNAIMKSASDLVIVPKKRKQKSLPAIKLHQDKQNKKLNKNENTITIHHGIVLNKMCDMQKEEIGKKSSSKKDKKMKKNNKKHVSNPSSTYTQERVKKVPRNEDKHNSGQKQSAGKTISKQKGSEMKQNKVHIKSVEAPINKRHLDKNKNYEKLNKQSNYRNHSPSSDSKKYILSLIKKCNNDNEDIKKKSPSRTTQTSTGSLSSNKSSKSKNTKTIKDRLRKQIWHWAKNSMKRSENWTKFLADNNITLDDISIDKLDHTLIDVDTLGIENKLLKRTVLWLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVQ2</accession>
    <name>A0A835GVQ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Connectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVQ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF164">
        <property type="entry name" value="CONNECTIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59638" checksum="1172F52B0626055A" modified="2021-09-29" version="1" fragment="single">LVKRQGDMETVVQYLLLALALTSVQISYTESRLNEKRRDKTERRYHGTQVKDNICEITNRESKIHCYCESTDVKTATRADCWVFNGGIDETDPIWSTFNTQPYLERLTFNVRSDGALKFIPFHVIHRMKRLQKLYIHYATLNKIEKKTFSNITTLKEITLMNNKITELDFSSFTNLPSLVNLTIKENKVTEVQRDVFVDLPSLKYLDLSFNSINLAHDGCFEHLTVLNDLILEANSITVLTRDTFRGLANLTRLDLRSNKLSMLGDLTFTELWNLNELLLDNNELKFLSERAFDGLALLQKLSMTGNKLKSINEGLLEGVRGLELLDLRNNEIEHFSYDTIKPILENLKMKNAVLYLSGNKLSCDCRLSWIQVLRNETKSEPLRMALDSVTCAMTRDDADSEEDTSNDVSTAIKDNKPAKSEQLYEIESNGDELQQDANEEFYEDTSAFKFEPTVQPVVANQLTIVNIPVETLPCPRELVRSGEDSLMLSSKDENYWQSGNSIRIIPKLLLVLTSLLISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXQ5</accession>
    <name>A0A835KXQ5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000493">
        <property type="protein sequence ID" value="KAF9407238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="31286" checksum="85B3EE9BEEB88353" modified="2021-09-29" version="1">MSSFIKTIAFNNPRKLISNVFIRTFTKAELPQFETLAVSVPKKHVYHVELNRPKKSNSFSRTMWQEINQCFTTLSLIPECRVIVLSGQGKHFCGGIELQSLVQLAAEADELEDVARKARYHYNFIKYAQETISSLEECVKPVISVTHNACIGAGVNLITAADMRYCTEDCWFSVREVDVGLAPDVGTLQRFPKIVGNSSVARELCFTGRNFDAKEAKEIGLCLDKGIRDSRKYSVKESRSGSNNQDQPPSVKLSDEPRRRLDEGSHSPSHQEPSTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXY5</accession>
    <name>A0A835KXY5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="8">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_000778</name>
        <name evidence="10" type="ORF">HW555_013642</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.</text>
    </comment>
    <comment type="function">
        <text evidence="8">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000688">
        <property type="protein sequence ID" value="KAF9405748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000256">
        <property type="protein sequence ID" value="KAH9641130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXY5"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9405748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9641130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="27256" checksum="A4901CE99FAA7DE2" modified="2021-09-29" version="1">MSRVLVGVKRVIDYAVKIRVKPDKTGVVTDGVKHSMNPFDEIAVEEAVRMKEKKIASEVIAVSCGPAQAQETLRTALAMGADRAIHVEVAGAEYETLQPLHVAKILAKLSKDEKADIVIVGKQAIDDDSNQTAQMTAALLDWPQATFASKVEKSGDGLTVTREIDGGLEVIKTKLPAVVSADLRLNEPRYATLPNIMKAKKKPLKKMTAKDLGVDIAPRIKVISVEDPPVRQAGSIIPDVDTLVAKLKEGGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYW4</accession>
    <name>A0A835KYW4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000334">
        <property type="protein sequence ID" value="KAF9409142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYW4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="136" mass="15747" checksum="4778DE535B1B77E6" modified="2021-09-29" version="1">MDSYPKYYIEKQKSPSYVEMYTKTNRDIVLVCNKAKQTTYISENAIKDNRNEAEELELTGSPLKLDLSLHTVLDDTMMTDEPQLWSKEEGTHSPISLDIARQIANLYNKNRDQVTTEDAVPLWILTNPEEDLTNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZJ4</accession>
    <name>A0A835KZJ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP-D-glucose phosphorylase 1</fullName>
            <ecNumber evidence="5">2.7.7.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_010702</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30387"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:62230"/>
            <dbReference type="EC" id="2.7.7.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GDPGP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.78" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000276">
        <property type="protein sequence ID" value="KAF9410126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZJ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080048">
        <property type="term" value="F:GDP-D-glucose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026506">
        <property type="entry name" value="GDPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058865">
        <property type="entry name" value="GDPGP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058866">
        <property type="entry name" value="GDPGP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884:SF8">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26216">
        <property type="entry name" value="GDPGP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26217">
        <property type="entry name" value="GDPGP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDPGP1-like N-terminal" evidence="14">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GDPGP1-like C-terminal" evidence="13">
        <location>
            <begin position="200"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9410126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="316" mass="36870" checksum="7BD49A6AE950F0ED" modified="2021-09-29" version="1">MYKLNKLTSDSLTSFTSLLKTKWNEIHNETDIFRYKIDDLKERIIDGKYFLQLNPDRRSKRRTPEEMTSICQPFDENKFNFNKVSSKEILFSLEGKDGDIHTVLVNVSPISRYHSLLCPSVNKCLPQVVTPDSLKLVLQIMFQIEDGGVRIGFNSICGFASVNHLHYHLFVEEKTLQIENVTWQHFKGEMYTLDENSTVPAFCFKIQKDSCNQTLQQVWKVLEYFLKKSIAHNILFTKRGLGERDDVVYLIVWPRRNTSGVKQLSAFNVAVLELSGWFPIYDEEDFNNVEAKDLEAELTKWKRDDFKTICEDIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZZ4</accession>
    <name>A0A835KZZ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000603">
        <property type="protein sequence ID" value="KAF9406368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006928">
        <property type="entry name" value="Herpes_teg_USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04843">
        <property type="entry name" value="Herpes_teg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="250"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C76" evidence="2">
        <location>
            <begin position="417"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="787" mass="89452" checksum="0DAEE28FA1FE9DE5" modified="2021-09-29" version="1">MVLGRKNKKAQYVAKRRKLTQLDENTSDKNSFLSSQAARKAELRSQEDLFNRKRRLDSDAASKALRRSKENRVKRCFRNMKNASCTKISRSIETPDQRTFRHAKNAESTAASRLNETPEQSSLRRATNTQRTAESRLNETPEQSSLRRATNTQRTAESRLNETPEQHALRLTSDAVATALSRAKLRTDFQNSINKFADTICLICNKLCYSKQVQSVRLASLPENILPNELIAQHDVISACHRCVGILRKSRTPTQAYWNNMSLDEIPPEIASLSDVEVRLLSRIIPFVKMVKLGGRFGQHGFHGQAVLFGQDVEEIAEQLPLRISSAGLVIICEQLESVERLRQFSVNIQKLRAALDWLIANNPLYRNVTVNFNNENYDVHEICHVQNDDVTHQEKNTNETTCFQDIGNNRRILRGSFHQSHSKFQNFSRGKQCTSNAAVAITAAKIKETDTWSPNIIDSILISGDRLYSSSIQSRRVPNTAEADVEYLRVHELQVNFEALSHSCLLQIQDETSSICGHLTVSIDGFPNLKNGLIQFFTESDVDGGAIVTCNGVSVAIWKNDNLYYLFDSHSRGPKGRVAQDGTACLMSFTNITQLWSVLKSNLPKSQGNRPDDDQYSITKITPDVHRLHQNETELQNDIYTTANTQQLQSSELTNENIVITSSVLRVVDEPIPELSTVIENNNCDQLPVHQLRRKTDAPLQIAREKRAEELSWFKLFPYGRNGLQENRAHSITPLDYCQARIMGADNRFQRHDYLFYALSVMEFYRAKQNVGVVLRMRQEKIDPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0F1</accession>
    <name>A0A835L0F1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC-2 type transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000358">
        <property type="protein sequence ID" value="KAF9408842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0F1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="209" mass="23623" checksum="516B86FC1F8F8869" modified="2021-09-29" version="1">MYSVLHMFPEEFPLLNRELKAGLYSAPVYYTARMVALLPGLLIEPTLFTLVVYWIAGLRGSLYAFSFTVFLAILVLNVAIACGSFFSCAFGSMPVAIAYLVPFDYALMMTSGLFIKLSSMPKYVSWIRHLSWLMYSNEAMSIVQWDGVQNITCITNEAGMPCLSTGEEVLTTYDFQSSNLWMDVLALFILYLAFHSLAVLALRHRTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0H9</accession>
    <name>A0A835L0H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000349">
        <property type="protein sequence ID" value="KAF9408975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF32">
        <property type="entry name" value="RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="216"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="692" mass="75347" checksum="F05AE067376E5436" modified="2021-09-29" version="1">MFVGRPEKCRSVSAGGTGGATINERHSYAEGRVPAPHGTPSSPGAAAAQRKVAAACFASRRLLEETLAKSGNPPTIVLPPKGYWVDGVEDTLPEGEDVEPRAQPGTPRQASRRHNIDTDNSAKYYRRFFLGKEHINLVGSDENLGPVVMSLKNEHVASQDHTRILLRFRTQTIHGLIPTTRSGVVQSPLEMAKMLNDQVNIDNFTPVMCLNASSLIAQYDEHVLVNCFKFGVLYQTYGQTTEEQLFGNNEISPAFEEFLDMLGQRIKLKDHKGYRGGLDIINGHTGTEAVYETYNDREIMFHVAPLLPHTAGDAQQLQRKRHVGNDIVAIVFQEKATPFTPDMIASHFLHAFIVVTHLESAGGETRYKVAVTARTDVPFFGPTLPQPSIFRKGREFKEFLLTKLINAENACYKADKFAQLELRTRASLLQNLVNDLKTKTTEFLGAGVRLEPGAVSPQPDGTPKQDGPGSRFIDTVKKALISKVRSPSVDTNLSGDSNKNALNKNKFVPNETHTPNSARSKSSVASSSASAVSVRSAGGSGASHASGESSPDVTSRAAPPRPPLTDHSDDSSLNSVDLDPLGGVYVDSDTGLESMSSAEAGAACGGCAAGTGREVTPRDAEMLRQEVCRLKNDKLDLLKQNITWQNEIKSLREKELTLQAELNSMSREMRRLREQQVTGTIIPNPSTHDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0R7</accession>
    <name>A0A835L0R7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000323">
        <property type="protein sequence ID" value="KAF9409354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0R7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="118" mass="14074" checksum="4BBEE7D47701EAAA" modified="2021-09-29" version="1">MGGCWSSKSDGGRSTAYVRSSFRDERTHRVPEVRPEKLKPLYGEYRCGRCKNFWTSRLSWPNKYQQCKRCKSYVHPKNQRELRPTDYKRGYEVGLEHPREFCEMCKKMGKYCATYSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0X0</accession>
    <name>A0A835L0X0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0X0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="603" mass="66868" checksum="C60ED102FE600CDB" modified="2021-09-29" version="1">MMKLYLMGERQRTAIPEEMATTSTAVATVPPQTQEVTPTVVVIMEKLRKLCVCILRTQYTYYKHDYSTKSGLLKDINVLDLSRVIAGPFCSMTLGDLGANVIKVESLDGDEARKWGPPFIKDSKDSFYFLSVNRNKKSICIDFKSQEGKKVIYDLARKCDVLVENFVPGKLDQLEIGYDKLKVINPKLIYCAITGYDVIAAAMGGLLNTTGEPDGDPCKAGVAITDVTTGLHAFGAIMTALYYREKTGKGQRIDCNLLSTQISSMINIATIYLNCGIEGQRWGTAHANLVPYQAFKSKDGYMVIGTGSNPQFADLCRIIGKEELITDERFKDNSKRVENRKEIIRIISEVIGTKSNKEWSEIFKNASFPCGPINKMKDLVKELPHPDAGTVKVVGPPTVYGLGGNDARLAPPRLGQHTRDILANFLGYHDKKIEGLLDKKVEPVERVAVITLRSTRAEARKKVVWTEDTVDNENMNKKKSKCCCIYEKPRKFDESDSSDSDDDECEHCFGHVEKKKKKGKHYHNHDANCPHSETGAATQGGTVTITETETQPAPEATATLTLQPSPTPAPAPPDKKDDIDYVTTSELGAEREDINWHVSNVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L144</accession>
    <name>A0A835L144_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000398">
        <property type="protein sequence ID" value="KAF9408220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L144"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004941">
        <property type="entry name" value="FP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03258">
        <property type="entry name" value="Baculo_FP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein N-terminal" evidence="2">
        <location>
            <begin position="155"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FP protein C-terminal" evidence="3">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35776" checksum="DFB77000E2F4B873" modified="2021-09-29" version="1">MVQCNKCKLFLSVTKDEVVKCKGVCETIYHKKCVLNNKQFIKTSVCDDCQKNKGSPAQPISSSTLNINMTEASAEKVLMEVNKKLEVLYNVERKISDLTNSVEFYADIYQTLIEYKEESQKKIKALEQKNIYLEKYNKALEERIQALEVKEREAEIEIHGLEAKANEDVKEVVQNIAKVLKLNPEDVEIAERVGRQKLEDAKPKVIVATLRSKGCRKNWLIAKKERKITNDTVYKNGNNNQVFINEGLPKFKRQLLWTVRNKLKPLNYQYIWVQNGNILVKKNNDDKRIYNISSEKDLDKFQELPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1J3</accession>
    <name>A0A835L1J3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="13">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="5 13">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_009746</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="5 13"/>
    <dbReference type="EMBL" id="JACKWZ010000224">
        <property type="protein sequence ID" value="KAF9411451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1J3"/>
    <dbReference type="UniPathway" id="UPA00781"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="15">
        <location>
            <begin position="171"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="203"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="297"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="12">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9411451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="601" mass="66797" checksum="7C7F4F0ADBFB67BF" modified="2021-09-29" version="1">MSAASASSSGSKMKNVENDNSSKTTVGSVKKKSSSDKNKKSESNTNSTIIKVKSVIPKRRQDLLKWYGWGYKDSMFKLDGNTATFTGNRYSIGGHTLPYLAQWAIEKFGIDPSREPKIPELPTKFAESRLPESIRVELEEIAEVSVDGMDRLIRAHGQTLKDMAQLRTNSFPRIPDAVIWPDSHEQVEQIVSCASRHNFVIIPFGGGTSVSGAVTCPAKETRPIVVLDTSDLNSILWLDKEQLLARVQAGIVGQDLEREMRARGFTVVTARGVFEKNCRVPRMSCGPEWEHVIMGSEGCFGVVTEVTIKIRPLPPVVRYGSLVFPDWESGFHFEREVARQRLQPSSIRLMDNEQFRFGQALKTENTWGGVLLDGLKRLYITKIKGFNPAKLCVVTLLMEGSAEEVSERESKLNSIAAQFGGIPAGATNGENGYTLTFVIAYLRDVAIEYDVVSESFETSVPWDRTLALCANVKQRIRNECAKRGIDKYLISHRLTQTYDAGCCIYFYFGHYIGNCADPVSTYEEIEEAARDEIIACGGSISHHHGVGKLRKKWYADTVSEPGRQLLLAAKKALDPDNIFALGNMAFEEHSNNSDVSVKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Z2</accession>
    <name>A0A835L1Z2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000792">
        <property type="protein sequence ID" value="KAF9405185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Z2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50467" checksum="42A0BA83DA4B8454" modified="2021-09-29" version="1" fragment="single">RSRKLKTPTCGIPSETACPTFEVDIILYLVLTCSIAMEEIIDDGEDTSDSEVIVNSQQEYEHIQINSRKPKKFNRSDSSEFLPNKRVDRNKNQNEQIEDINTYEVCITSMESLPKQMALAKLLRMENIKGISRIKYKSFNKVLLQFNKEEEANNLLSCQKFKDMGFRCQKVNELSLCYGIVKGVDMDMNENELQKLLESESKIISISRLKRLNADGKWVDSETVRICFEGNTLPTHVYAYDCRFKVDAYFGHVLKYCPTKKKLCPKCGGSHENCDTKELKCLNCKGPHIVLDKTCPLYLKEKQIRLIMSKEQIPYRRALQSLIENREKTTNFIVRGMRTYSDVVSKTPVQREARVFNTNLMEQSGEIALETRSSKETAKNKKPLKTKQRIETTQFEAEQVVETESGASQKEEVEKGNQQDEQLRYRFEFTKLILKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L237</accession>
    <name>A0A835L237_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Parkin coregulated gene protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_002817</name>
        <name evidence="1" type="ORF">HW555_008060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000149">
        <property type="protein sequence ID" value="KAF9413857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000938">
        <property type="protein sequence ID" value="KAH9627780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L237"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9627780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29266" checksum="2D02AA20632DAECD" modified="2021-09-29" version="1">MVLLPPCAPELCGKDFRHSLKKPSPNYPYGYKTKKPRVVPAFTIQAMQKNTKVLPPPKCGVFDPMPPRPTMFRKCYQRGEFPVCIEFTNYGKRLAWKVPIEKLDFHHYLPMFFDGLAEMSYPYTFIVERGIHDLITKGSYKVLPVVPQLIIPIKNALATKRPPVICHALKCIQMLVTGCEKVGEALVPYYRQILPTLNLFKDKNRNIGSGIDHTTTRGENVADLIESTLQTLERYGGPDAFINIKYMIPTYESSVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L263</accession>
    <name>A0A835L263_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L263"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13193" checksum="3E0B2014019008EE" modified="2021-09-29" version="1">MRIYCRATEGGLAPGGDGDMPVGGPKTPQQIAAQRRLQQTQAQVDEVVDIMKTNVEKVLERDQKLSELDDRADALQQGASQFEQQAGKLKSKFWLQNLKMMIIAAVIGIIILALIIANFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L303</accession>
    <name>A0A835L303_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_007110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L303"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF645">
        <property type="entry name" value="LP14331P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="217"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9415234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="458" mass="49997" checksum="EE596BBAB2161CA8" modified="2021-09-29" version="1" fragment="single">TRDSSFFFQATGQRIGTVVQAVGTFGFALVLSLIFEWRVGLVALTFVPIIIFVLYKEGRMTYAATSGTVRAMESSSKIAVEAVANVRTVASLGREDTFRREYGKQLRPALDTAVRSSHWRGLVFGMSRGVFNFVIATSLYYGGTLIVNEGVPFQEVFKSAQALLMGATSAAQAFAFAPNFQKGIKAAGRVIVLLGRPSKITDPAEPAVKQFNGTGEASLQNIQFRYPTRPLVRVLKDLNLEIQRGKTVALVGASGCGKSTVIQLLERYYDPEDGIVAQDGVPLPKLRLVDARRAIGFVQQEPILFDRTIGENIAYGNNEAHVTHDEVIEAAKQANIHNFITSLPLGYDTNIGSKGTQLSGGQKQRVAIARALIRRPKMLLLDEATSALDTESEKVVQEALDAAKAGRTCVMIAHRLSTVRDADVICVIHEGQVAEMGTHNELLELKGLYYNLNRRGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L391</accession>
    <name>A0A835L391_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000504">
        <property type="protein sequence ID" value="KAF9407115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L391"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="15321" checksum="0DA6856E6855ED98" modified="2021-09-29" version="1" fragment="single">RVHTLELFAVDLQNGGRGTLQLQPSTCVGGSRRPKKTIESINSRLALVMKSGKYCLGYKQTLKTLRQGKAKLVIIAKNAPPLRKSEIEYYALLAKTGVHHYSGNNIELGTACGKYYRVCTLAITDPGDSDIITTLPESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3C5</accession>
    <name>A0A835L3C5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000219">
        <property type="protein sequence ID" value="KAF9411627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="103" mass="11058" checksum="087D232A92313140" modified="2021-09-29" version="1">MTNTGNVADLLDLGAALADEGAALRGGHDEPQRDGGAGPTATTLVELRAPLEQYNEPKGLVHWQVLCNGRTHMQTHRGCDETVLEACGIRSVLASEQHDFYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3C9</accession>
    <name>A0A835L3C9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Failed axon connections protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_008519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000168">
        <property type="protein sequence ID" value="KAF9413165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3C9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="4">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28364" checksum="01D3325A12359630" modified="2021-09-29" version="1" fragment="single">NVDHKAKFRSKKGQLPFVELNGEEIADSAFIIKELSEKFNKDLDASLTPEQRVVSHAMISMIENHLSWVVLWWRAKYPDSVIKGYQVNLQNALNTRLPNPILNFCYKLAAARKGMKKAKAHGIGVHSQEEILEFGKNDLRVLSDLLSDRPFFFGDEPTILDVVAFANLAQVHFIDKEVAHPLRDAMNELFPNLVGLVSRIKERAFNDWDDICSTLDLNAHLPKPAKEVKETKEGTGPAEKQPLPDEPEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3R3</accession>
    <name>A0A835L3R3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_012291</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000433">
        <property type="protein sequence ID" value="KAF9407814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3R3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000003">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="132"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="407"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="523"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="637"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9407814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="770" mass="86667" checksum="CDEF99A870046C70" modified="2021-09-29" version="1">MHISDMATYEEFIQQNEDRDGIRFTWNVWPSSRIEATRLVVPLACLYQPLKERPDLPPIQYEPVLCTRNTCRAILNPMCQVDYRAKLWSCNFCFQRNPFPPQYSAISEQHQPAELIPNFSTIEYTITRAQTMPPIYLLVVDTCLDEEELGALKDSLQTSLSLMPQNALVGLITFGRMVQIHELGTEGISKCYVFKGTKDLTAKQIQEQLAIGRVNAPNPQQRPGAPAPQPPAHRFLQPVKTCDMALTDLLGELGRDPWPLGVGKRPLRSSGVALSLAVGLLEVTYPNTGGRIMLFLGGPCSQGPGQVVNDELKQPIRSHHDIHKDNAKYMKKAIKHYEALSLRAATNGHSIDIYSCALDQTGLMEMKQCCNSTGGHMVMGDSFNSSLFKQTFQRVFAKDQRGDYKMAFNGTLEVKCSRELKISGAIGSCVSLNVKGPCVSDQEVGMGNTCQWKMCTFTPSTTMAIFFEVVNQHAAVPQGGRGCVQFITQYQHSSGQRRVRVTTVARNWGDAAVSLHHISAGFDQEAAAVVMARLVVYRAELEDGPDVLRWLDRMLIRLCQKFGEYGKDDPNSFRLSENFSLYPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFGGPPEPVLLDTSSIQPDRILLMDTFFQILIYHGETIAQWRELRYQDMAEYESFAQLLRAPIDDAQEILQSRFPVPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGGDGGAPVLTDDVSLQVFMEHLKKLAVSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4H0</accession>
    <name>A0A835L4H0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_005495</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4H0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9417398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="57375" checksum="F30E540238B3A5A6" modified="2021-09-29" version="1">MNWPIYLIGGALSAVWLLWRYKNRRMIQMGNKLPGPPTIPLLGNALMFMCQPEAFIKVLKDLMTEYGNVSKFWLGPDLNIVINNPDDLKLLLSNTKTSVKGPQYKYMADVLGGGILSGSGPIWRRHRKIANPNYGKRAIEGYSKVFNEEVDLLLKKFRCMPRKQFDVYQQIVRTTSHAVCRTLMGLTKEQTTKLPHIEELIETSPSIYEVVFRRMTKWYMQIDPVFWMSTDYYFQKHFIKIMTDFCEVILQHRTERLRTLEDSKRELMNSEDDSSVNTELSVIDRFLLSQELNKDELVQETFTIFTSSQEATAKISSYVLLMMAYHPKCQEKLYAEIKSIIGDEDRYVTDDDLKRMPYLEMVFKEVLEAVPHRSYFAEDGDYTLPAGCSLVAPIFHLHRDPRFWTEPDRFDPERFNPENVKTRNPNAYIPFSLGQMDCLGRFFGTKLVKTICVRVLREFELSSTETYDDLRVAISISVVSLNGYPIILNPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L570</accession>
    <name>A0A835L570_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L570"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63678" checksum="F66DB57E89148922" modified="2021-09-29" version="1">MIVNKKQSQYNDQNTPLFSCLTRWNLYICILKFCDGCEEPEIEKVPPCPLQCRSRQCKAYQTKSKFDPETKPIVWVLGGPGSGKFTQCTKVEKTYGFTHLSTGDLMREEEKARTPRAKCLGSIMARGGLAPNDVVLAVLKDAMEEAAKKGTHGYLIDGYPREKSQGEEFERTIGPVAASPHTLCQRLLGRAEASKEDSRRKDDKYSVMKLRIATFIENNKGILERYGNKVKRIDAEQSPDEIFAEVQTYLEPIKSCDECEEPEIDKEPPCPSQCPDRQCKAYQTKSKFDPETKPIVWIIGGPGSGKFTQCAKMVETYGFTHLSTGDLIREEVKAGTPRAKCLGSIVERGGLVPNDVVLAILKDAMEEAAKKGTHGYLIDGYPREKSQGEEFERTIGPVTLILYLEASPRILCCRLLGRAEASTEDNRRLDDKYSVIKLRIATFIENNQGILERYGNKVKRINAEQSPDDIFLEVRTYLEPVVAQAALMEAEKKQAEAEEKMKAVGALPRSSMPLARFFRPKSVDVDSKRLAAVAEVADAEARVTAARNTAEAARARLEEFEERNGKNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L578</accession>
    <name>A0A835L578_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L578"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="7697" checksum="7FC73AA504083B1D" modified="2021-09-29" version="1">MFPSLIEQFMPTLLKMEDVICATYTQAAEEPNIAVFAISAWTTSTTTASGLTTALAEGTTWRLLRASPQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L591</accession>
    <name>A0A835L591_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L591"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="26331" checksum="8CE38246B124421C" modified="2021-09-29" version="1">MKLTRSLEVICWNSRPYFLTDSAYFCMFISLWAIDVGYTCLWTSGKQGCSLSSLSSGGAATTTRPHHWQPAARLAPPSRRPPPHHSSSLIDWFTVQKTFQTGMYVCTRTETVVPGEQGGGPVRRVQQAQRRDVGLQGAGAGPAHTAPAYGASAPRTLAAARWMDMVQQICKRSHLNTPQRASRAFASYQYWASAQKHPSLQTGTSQWPRMYQSRALYQTQIVVKTWNKYVGYFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L592</accession>
    <name>A0A835L592_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000287">
        <property type="protein sequence ID" value="KAF9409958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L592"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16823" checksum="A06666DE3BAF8553" modified="2021-09-29" version="1">MDSVTLSVNLKDREKERFSPSRWVSNKAMDVWYGNKSMVDIFSSELANLIEKIATRPGRSPDARFPHYLKLIVNSSEDQYENEVPKKQIIQPIPQQIQEGVQIISRVDINFINGDNETVHTIQLKPQADKKYEYLKALAKKKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5L7</accession>
    <name>A0A835L5L7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000263">
        <property type="protein sequence ID" value="KAF9410439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5L7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000116">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000193">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60827" checksum="579C6E59A44257C7" modified="2021-09-29" version="1">MTNFFLMSPLFREPNDNMCNVNHIRKKNCYDNIELPLPLPILMSNDKKADENELSIGLIKSAKRTGQLSLCNRGLGTVPDNVWKIDELILDESKDVDFSRSDSNKWWTAEPLKTLDLSSNVIKVISGNVKYLQHLVNLKLHDNAISSLPPEFGELNNLMTLSLAHNKLTALPKEFYKLTELRWLSLSHNEILKIEADFGDFVMLTFLDLSHNKLTMLPPGMGYLVRLVEINLSHNQLEELPPDIEITEEFCDQMQHLNVLNIRDNKLEVLPENISLLQKLKRLDLTNNNLNKLPRNLGLLSQLQSINMEGNKLSFVRQDVIRGGTERMMKYLRDRITEEVVNESRLTPEEWPDKYTLKKSQALMVPGRELENVPDHVFKAAAEAEVHIVDFSKNKLTALPSGIVQVSDTLSSLVLSSNNLSSLPPEINRCRHLQYLDLGKNLLMELPPELGDLKNLRELVISNNKFTKIPRCVYELDNLEILLAAENKIDEINVSSDALARLKKLAVLDLTNNSIYTNSGVDGELFPTATARHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Q8</accession>
    <name>A0A835L5Q8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5Q8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="703" mass="80186" checksum="078B81AC17A92E98" modified="2021-09-29" version="1">MRYLDGFKMPKVTVGKKYSKAYTEEYVDKALQAIKNGMGKKTAANKFNIPRATLQFRLSNLFVKSRPGPDTVLTDAEEKEVVKWIISACRKEFPRRKEDVIKSVKLYLDEHPRPNSFIDNTPGDGWYKLFLKRHPELSIRTSEAVTSASSKLSEKQIRNWFKQVEEYLKENDLFNILSDPSRVYSGDETNFILCPKNTKVIALRGTKNVYEVDHAQSKSCVTVMFTFSADGETTPLMIIYPLKRMRSEIQKSMPSEWGIGLSDNGWMKAELFIQYIQNVLHPALMKRNITFPVILFLDGHKSHTTLQLTQLCQNLGIILIALYPNATRILQPADVAAFRPIKVMWRKAVLEWRTDNLTKSLLKTDVAPILEKLLPKLNKTTLKNDFKACGLCPFNPDQVDYTKCLMPSKPVQEMLDDNCSTSLNYQTYEEIVGPQLVRKMKNQMVGQGGHKDRSNLNEQNNDGSEDLNTMAAFNELTTMPTDVELLLNEPELSHEPQFAGISKANTMVVDYSETSGHEIGGEHVELRYHVVEKLPLESCTIYSSINDSIPEAAQTVDIISDFQRENQSITPINLIPIPSTSRQSVELIDRKWVLVDNMPIEVPTNAQNINDFLKLPKTPIKTQKAGTEHRTFVLTNAAEAENERSFKESEQSMVKKALKKGPILDEPANFRVSRETRKDKIKVKENRLRPMTNEELLKVLEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5W7</accession>
    <name>A0A835L5W7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MIS12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5W7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="204" mass="23239" checksum="7551DDFAF32A4BD2" modified="2021-09-29" version="1">MIKTKPWTGGTDEEYETQHFGFGTQRLKIAVRQMVEQKITNGVKDMESYLQESLDLNETDKSTLTKSCDKLIHLYCERAGPSLEIIDEEIERLLKIPHNVLLPEDEVQVEQTSDSEFEKLKEEVASLRRRVERGALMEALLSAEEEELATLEKVCETAKKDMEATDLLCKSADNSDSLRAVQSETQFLCASASFLKKQNDLFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6J3</accession>
    <name>A0A835L6J3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6J3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19867">
        <property type="entry name" value="DSRM_DGCR8_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="709" mass="79933" checksum="035F2CDDEDF62816" modified="2021-09-29" version="1">MSEETQSELPAAKKQKLNDGEASSSQASASNVLKENQENGEDIKFGSEDSYGNFVTPEELERLREFKVLDEVKSNDEDTNDEESDSSDGLPEEEIEKMLEEDLPEDFKGAPKQKEKAYITRQTTVLEEKGVNHFEVLPLDWIMVRHISGMPIYMHRATRVCTLSKPYFLGSGNTRRHDIPISAIPCFAYRKALEEEDKQKEIDKRIAEQIRTGTWIINSQSSKADYSENSQDSSTGTAVTGDAIELQCDIEMKDAKLCPDFTSDVTTDEVKETTVGNEQENCSVGKDEPIETLPGTSTDETQASEMNNAENGGNAGTSNGELDIRPSRQPVVLPGGIVMPPPRVETVSTSWKTQHLSAEQINEYCRRLFKFKTVNIMHFKRWADRRKYTKARKTLQYPTLPEGTKLITIPAQPANTGEENAGGGKTTKRDWVMNMNGRTYLSVFHEYVRRALQKQPVYEFKQLENASTPYQATVFIGGMQYGVGHGSSKRQAKSAAARNSIHILIPEMKDELDEHAPNNAPNDANEPDFTFFDYVGIEDPRITEFCAATCEPSPHDILRTCLLRNFGAGDRHIHTEMKKLEYQKMELTMKVGKHTATVISKNKKMAKQRASQSILQALHPHVRSWGSLLRLYGSRSVKSCKEKKLEEQQITLLQDKARHNEPNYAVLDKLRNEMRKLRERDDAVVPIGTLLVHEDLPTHSGSNLNNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7U7</accession>
    <name>A0A835L7U7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_004993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7U7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF76">
        <property type="entry name" value="HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="763"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123044" checksum="DBAAB4EA920109B4" modified="2021-09-29" version="1">MFCWGNATHHELCIEGPETLDLVIKPTLSKWRESNHIKSVAAGEFHTMYLTNSGHLYSCGNNEVGQLGRHTENREGKTPALVETFKECTVSSIACGIQHSVALDEWGQLFSWGSDSMGQLGSNLGMHAQDKPKFVKVLATRNVIQVACGAYHSIALTNNGDLFSWGANSYGQCGLGTMTNKEMIPQAITSLLGVPIAMIACGSNHTFALSKSGAVFGWGKNTHGQLGLQDRENKCYPSHLKTLRNVKVCHIACGEDFTVFLTLDGGVFTCGTGEYGQTGHGTTKDELVPRKVMELMGSTVTQVACGRRHVLCRVGDRILACGYGARGQLGCPHMAYALVPTPVSFTPTDETPTENPGQSKPKKKLKVEAATGITRNSNAGVSKLTVESSVPLKIYISIMFNFSQEIFKGPIKVFAGGDHSFLIIDHDKSGPVDFRVQDHTKQIVTLTIPKLAACEVFKDSDVVNQDMLAYLETVFGSLACVNGSFLAPNNAHFGCNTKVPGVDLRKAEEAFTLVSRFENTTIKELIFNHLTENIIKKMKVSPPDAEALRMFLILPLYHEMRNPRRHVELQGPFAEAFNNLSTHPQRIVNLWWEAQTPEYFEMLVDIFKSVIVYELMQPTVRANKKLYFTHSIIQILNTLSSLNKINFTNPKKPKIPAECFYIEDLSNHVDIATDYITWLSDHTSTHPHMCNYAFLFDVQCKSLLLKIDQQLQMQIAISRAATQIFTRLFMDPTYEYQRDQFLNLTVSRNHIVRDTMTQISSHETSQLKKPLRVEFVGEEAEDAGGVKKEFFLLLLKEIFDPVYGMFKQSEETNMIWFSNNPFEDDVMYYLIGAIYGLAIYNSIIIYVPFPLVLYKKLLEEAVMLDDLSDLYPTLANSLKSLLDYPDEDVEEVFSLCFAVNTEVFGQIQVHPLKENGENLPVTHENKEEYVELYVDFLLNKSVENQFKAFNQGFQKVCGGRIIKLFRSHEMMSVVMGNEEYDWEVFESNCEYKNGYTATDPQVRWFWETFHELPLEDKKKFLLFLTGSDRVPIQGMRDIKIRIQAVADDRYFPVAHTCFNLLDLPRYKTKERLKYHLVQAIQQTQGFSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8V0</accession>
    <name>A0A835L8V0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ropporin-1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ropporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8V0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952">
        <property type="entry name" value="ROPPORIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9414659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27263" checksum="C0432357A962584D" modified="2021-09-29" version="1" fragment="single">MKMPELIEQMYSSQQIVIPPKYPYILKRYCKAAIKTQPYDLLRWSFEYFKALAEHRPPPVKLRLEYPIYSTEGGLTRGCLKVLAHQLYGMSDIPLSTLKQAWNGFCLDSMELQRILCLCEVYHRQDDVPYLHFLAVAGGMLTKCLTHTMILLCESLTKEPDGGSAAIPVEEFLAMYLYLAKMDASKDVQYHNGFREGSAPEPEVEDEEVTQTEPTSEQRKLKYLSITRMQESGMLDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9M7</accession>
    <name>A0A835L9M7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000106">
        <property type="protein sequence ID" value="KAF9415630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9M7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="594" mass="71033" checksum="55A01110CFB5743D" modified="2021-09-29" version="1">MSCLEKKRKPMVPLKTLDIIFRRRYVPNTQHYFTNRKHAVKQDEKQKKQMKPFRIPKSEKLLSYIKYSDRKEKVSAKERLAQPLHLKDNLRIAATRDISKRLFVEEPPDDVRAVVEIHPEFYTVIEGRPLRCFDDIKVYLNNIRAYAMNRQQIGYRRDLILKIEKSDVEESEHYEKIFDKLKQHIKNFQTFLTEDYKKACYKVARAEKVYNTLLAKDSEFLGYVSSLTILNNILFKLDAIRNILKTYRSFLTFVAPLSWRQQNDETLRGKTMSIQFESGEFATDSDLIESMDIEKTVEMAKVELKNPLPASLFFKTPEQMMYLFRSMELQSREYIIQLSKTDGPNRLLRDRMKQLKQGQAQESDYFQYYIDIINFEISRESFNEKHLRDKFFRILNESFYDSIASQTTLKLKICIEYVYEQVFGKCEEGHHSLQDPLKILEVMYEDYNLRLDALDFKIVCQAQNDFFAQDLKMMHNANDAQRELRAFREMTNAMNKAFWPPAKFVRPPIKKFLDKKKQYRLKTTEKKKNEIQSGERMTPKKYKLSMEEREGLLLFTEWCEGMNPAPFLKEYYEFAKPVFEWEPQKSKEFNPIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9Z9</accession>
    <name>A0A835L9Z9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9Z9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF41">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="252" mass="27441" checksum="881126A3A3C87F0C" modified="2021-09-29" version="1">MLLVSWIRKRDLHILTVGVHTYSSDARFAALHADGSDEWTLRVAPAQPRDSGAYECQVSTEPKISLSFRLTVVVSKAEILSGPELFVRAGSDINLTCVAKYAPDPPSFIYWYRGEQVVNYAQRGGISVETEQRTRTSRLLIARAAPHDSGNYTCAPSSSESASVIVHVLSGERPAAMQSSGSTPPRLNRAILATLTALTTLRQPRPALLVTLPVAAHYVSIPTLLITLLFANALVKFLSKFTTAHIEPTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA15</accession>
    <name>A0A835LA15_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA15"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="29266" checksum="3E34C165AE35A61C" modified="2021-09-29" version="1">MKLNVSFPATGCQKLFEVVDEHKLRIFYEKRMGAEVEADQLGDEWKGYVLRIAGGNDKQGFPMKQGVLTNSRVRLLMSKGHSCYRPRRDGERKRKSVRGCIVDANLSVLALVIVRKGEQEIPGLTDGNVPRRLGPKRASKIRKLFNLSKEDDVRRYVVKRLLPAKEGKENAKPRYKAPKIQRLVTPVVLQRRRHRLALKKKRLAKRKQSENEYAKLLAQRKKESKVRRQEELKRRRSASMRDSKSSNQSAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAT6</accession>
    <name>A0A835LAT6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAT6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033109048" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="523" mass="59742" checksum="CB4C47F9E26ACE80" modified="2021-09-29" version="1">MKIFMYLFLCLSIFAGHYEAARILAVFPNPSISHQVVFRPLTQELAKRGHEVTVITTDPAFPEGKTPANLTEIDVHDISYDLWKNIFLTSTKGNKDDVVMAMSAIVNALTAVVDAQLKDDKIQNLIRDKSKQFDLLLVEACVRPALVFSHIYKIPVIQISSFFATFDNYPNFGVPIHPFLYPALTRQRLNNLTMIEKIKEFYNDFMLTRLYENNMEKENEMLRKHFRDVPPISELNNNVDMLFLNVNPVFEGIRPVPPSVVYLGGLHQVPYKPLPKDLQSYMDSSKNGVIYVSFGTNVDPTTFPADRIQVLVKTLSQLPYDILWKWNNDVLPGRTENIRIAKWLPQTDLLIHPKLKLFITQAGLQSTDEAISAGVPLVAIPMFGDQFFNAERYEYFNIGKKLSMEKLTVEEFTNAINTVINDGSYRENIVKLRRIIQDEPMPPLERAVWWTEYVLRHGGARHLRGPAANMSWAEYLELELVLTLLLGLLAVISVLLIGLRFLYKIVFGNTVTTTTKAKKSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAU3</accession>
    <name>A0A835LAU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135730" checksum="A179FFF2AEDE4E7A" modified="2021-09-29" version="1">MSKEINRRKVTPVGNSWVICKSKSHPGHVYYFNSLTGQAAWNLSDAEIEKAKQTTTRLEQLPGAELACPEPKDKPPSSSSNAEPTQPALKKRIPPFTNSQMNIMPEQSSSLLANLNIPLNQMTSILQGTQLTNNSSLGPFCNMNLLNNPTPTINLNNGTPMFNPKVWAVPQAQQIFLPTPIAPIVNQGPNSLNGMYNNLVESTGLILDNLNNASSSSNYIGSHAFNARDLKYRKGFQQPINKKPGFTHKKDLRQMLSFKNKFQRKPGGPGAHINSNKFGNHSNDFQNRIANKDNKCMDSQTLEDSSKIDVTPLKNLAPVDCISDDWFIVMDLEVLLNEFKFLNTITDSDEKCHLMVPKRVIEELKTYVTCTENIQARRILRFLSQQIEIGYAFMAENPHGAEKLSMTEVIDATCTELLKKKYHFVLLTNDNELMTRTSLACNIHMFTISEVHNLLGIQQKKQPVLTTNVPKTVVPKPKLSVNELLNKIKITVPNNFPSNQDTSPDIDTQYVDTIEEDVKTKPRQDDITEEPVLTKQTVDTGIQTDFEDITSNSSVSKENEELNRVSNKIDIRKEVVIRPPETSVVVNVSDKKRAIKLKRSASNQPPVNSYEKRQCKWRRRHTTPQPNKQIPPHNNENINDKELEANTLSNDNLKEHEEPTNDDPASESTDNRVINDSVESRESSITAYPRNSVSQENVTIDETSTSGIISNTESSVDELNLTTSSNQALHSKTNDNSMYGVESTTMEQYLKVKCDEWISRFVQIMEEVLSQVLHQDPPFSNSKMPPPWTLHEAAVCISIKFSDYKVIKEAANKLSTMIFRVSDVKGNISLNLTAYQYMQMYSYGMQLLGALMEAVSNIEDIKIAVESLNTLLHDIKNPCIDHSANDSFNDNAHEMSSNNDAMSHSELPDNKDGGSEYDHEMIDDNDNIAEINNKSPVKRTLVQDESPKQVKFIRNININPSLFKHLNFPKSNVAKNSLTDKSNLQSEEKTNNSRVEEINTVETATETMEKENNAPTSQPSIVRKFTAFPELEKKLQISNNLYENHDEELDYDEDEEYLTEEYCSEEETNGELHSDPNSKTFEGVVSNMEETDSHVERDILQRIDDISSFNENNEKFKYAMYMFIQEIKDALSQVQILCMLDNETNNSRRSMSQLLVQAEVNLSEVDTELLSKYRSSLSKCKECADGCLKSAQDIVSRLKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAZ6</accession>
    <name>A0A835LAZ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAZ6"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000002">
        <property type="entry name" value="Phosphoserine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="28138" checksum="0DA8BC709E742AAA" modified="2021-09-29" version="1">MALYSLKTNIQYATLKTLSLVSISVMSPQQSIKDLFRTADCVCFDVDSTVIKDEGIDELAKFCGKGDEVKRLTAEAMGGGMTFQEALKKRLDIIRPSVSQIREFIETFPIHLTPGVAELVKELHERGVQVYLVSGGFRSLIEPVAELLGIPLTNIFANRLKFYFNGEYAGFDENEPTSRSGGKGLVVRRLKEQYGYQRLFMIGDGATDAEACPPADGFIGFGGNVVREEVKKRALWYVTDFQELISTLTLQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBS4</accession>
    <name>A0A835LBS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NSFL1 cofactor p47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBS4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000020">
        <property type="entry name" value="NSFL1 (p97) cofactor (p47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="311"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42048" checksum="ADE4DC1C743454D7" modified="2021-09-29" version="1">MSTNKEETLRQFCDVTGADEGRSKFFLESSNWQLDVALSSFYEHGGNADEAPSNPAAAASSLPTLSDSDMESPPGSPLATQKKDKKKAPTSKFATLDSLQQESSSDEEEGQAFYAGGSERSGQQILGPSKGGRKDIVTEVFKSVRERGAVVFEDEPSSTSRGRSAFSGVGYRLGQTADDHEPATAGGNQQQQADQPRSVRLRLYREGFTVDSGPLRHYTDPDHADFLNCIRRGEIPPELSGTGGEVRVSLEDRRHEECPRHIAKPQPFSGKGHLLGSPTPPTVGATAPVAGDVADRAANQRAAQEAVKVDDSAPVTTIQFRLADGSRLTGRFNHSHTVGDLHAYVSRAEPSYQLQAFALLTTFPSRELADHAATLAQANILNTTLLQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCB2</accession>
    <name>A0A835LCB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000079">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF9">
        <property type="entry name" value="FREQUENIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="193" mass="22115" checksum="81BF4DA59BD08BCF" modified="2021-09-29" version="1">MGSSQSFPGLTEDVLEDYTSLTYLTKGEILYLMKKFYSIDPEKVKKDFHHRFNREEILTKFHVLENNPFLDRIFSVFSSKGDGCLSFEDLVDLCSAMSYECPAEVKAAWAFRIFDLDDDGQITAKDISQIVDRLTLGVTDNRDHYIDEASKDKIAKVILDEVNFDKSGGIGQLEFKLVMARIPEFATSFYFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDK0</accession>
    <name>A0A835LDK0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDK0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="255" mass="28597" checksum="2ED5F2F04E32FE2E" modified="2021-09-29" version="1">MSSQIMSHGIYRRDSNEIQEKPLEIDTESNPDRSRSSSPKNMKFYKQIDEEKTILNQGKKSFCIDALLSRQLPENSLQDKMAHQKYLTIIHNKNYIGRYQDNYDSQIEQNMINKCEGRESPTSGQRSPRSGQSSRSASPGSDDGNRSGSYSPPISPGVEGGNEEYESYRPGIIPKPGLLPQNPALVAAQSAALFNYPQLSQPGALPPGAPLPSAFHHPGDRVLHHMQLEWLARTGMFYHRIPELGGKCKELFKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LE98</accession>
    <name>A0A835LE98_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 9 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LE98"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026193">
        <property type="entry name" value="NDUFV3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15880">
        <property type="entry name" value="NDUFV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16799" checksum="72D42F16B871D8C9" modified="2021-09-29" version="1">MAVMPKLVRGVMTPRVISKFNVVRYSYKLSDITMRFGSCSTSGSGSDADSKDNPGAPTLYDCRKLGHKLSANNVCPQFETLPDIPTGVFRNTTGEVLGRNAGKCFYYQNPEYFSFHHMSFYDFNLALRQYRKPCPQTNRKPIAYRRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>I0B5V1</accession>
    <name>I0B5V1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">REPAT31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004716</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-02" db="EMBL/GenBank/DDBJ databases">
            <title>Identification, classification and expression analysis of the REPAT superfamily from Spodoptera exigua.</title>
            <authorList>
                <person name="Navarro-Cerrillo G."/>
                <person name="Herrero S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="JQ619213">
        <property type="protein sequence ID" value="AFH57151.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="I0B5V1"/>
    <dbReference type="OrthoDB" id="7194370at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036439583" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH57151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="110" mass="12093" checksum="B0E7017EE5387F8D" modified="2012-06-13" version="1">MKCVLALSVFVLIAISSCFANDLIIGTSYNARLSWQHKAEYMGIPFKKRVKEVFYSDPGQQIIKGIIARDIDHTSGSATVTAGGVGFSFANIRLKSERGSGLNYQIEIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-12-11" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>U3MGC9</accession>
    <name>U3MGC9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="14">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_018174</name>
        <name evidence="18" type="ORF">HW555_007873</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="J. Exp. Biol." volume="216" first="4196" last="4203">
            <title>RNA interference of glycerol biosynthesis suppresses rapid cold hardening of the beet armyworm, Spodoptera exigua.</title>
            <authorList>
                <person name="Park Y."/>
                <person name="Kim Y."/>
            </authorList>
            <dbReference type="PubMed" id="23948473"/>
            <dbReference type="DOI" id="10.1242/jeb.092031"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; alpha-glycerophosphate cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="14"/>
    <dbReference type="EMBL" id="KF170736">
        <property type="protein sequence ID" value="AGW15345.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000142">
        <property type="protein sequence ID" value="KAF9414114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000281">
        <property type="protein sequence ID" value="KAH9640508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="U3MGC9"/>
    <dbReference type="UniPathway" id="UPA00086"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000088">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="16">
        <location>
            <begin position="198"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AGW15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9414114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9640508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="353" mass="38851" checksum="D3DF5AF443286349" modified="2013-12-11" version="1" fragment="single">MAEKILKNRVCIIGSGNWGSAIAKIVGRNAARLPNFEDRVTMWVYEEMIEGKKLTEIINETHENVKYLPGHKLPPNVVAIPEVVDAAKDADLLIFVVPHQFVRTICSTLLGKIKPTAAALSLIKGFDIAEGGGIDLISHIITRCLKIPCAVLMGANIASEVAEEKFCETTIGCRDVMLAPMMRDIIQTEYFRVVVVDDEDAVEICGALKNIVAVGAGFVDGLGFGDNTKAAVIRLGLMEMIKFVDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVAEAFVKTGRSIKELEDEMLNGQKLQGPITAEEVNHMLANKNMENKFPLFTAVFRICRGELKPSDFINCIRSHPEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1Q1</accession>
    <name>A0A835G1Q1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000957">
        <property type="protein sequence ID" value="KAF9404509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1Q1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="180" mass="19750" checksum="A92E7ED7EE7AE6E4" modified="2021-09-29" version="1">MRSDLDKICEEYATLDQVKNLRMEVESLKKASIVNNFQRSVNTKRGAASLLTSFECESGPMGLSPLCNAPVTHRTSPTVSPAKKRITFSDEGTLKTTPCRESNGLHIVGAHKTADTNTPSEPDPPAATAASATKDSPQKSFSEILSETKGEFKSQPLDDGFTLVQKKRLRNRFQGLYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G222</accession>
    <name>A0A835G222_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000585">
        <property type="protein sequence ID" value="KAF9406482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="4">
        <location>
            <begin position="226"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="4">
        <location>
            <begin position="405"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="3">
        <location>
            <begin position="868"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1329" mass="152543" checksum="80F3D75AEE46F090" modified="2021-09-29" version="1">MGSYAKFVSDYCKTWEKSGKEQLVKHVTQFIKDEDKSPLFTKSGKLSGLSQTIYDLLLCGLRGNLKKEAVLSVLREITVLHADIPSVILDVVSVLDAETCTDVQSEERTNFCYIVRELESFISDKLLKERLEIDTLQDAGTLKNKLFYTKFIKIKTKLYYKQRKFNLFREESEGYSKLIVELNHEGVDKADWKSLLEIIQSLIESFEARTHSDQLFIPLIKNYMGDPQVISEVLGFKLGNMEVLENYKEPPPLMTVIALLLQHQVISLDDIYPWLRPDDSIMAKEADKELKTVQDYIRKLSIVSTKGPQVNGATEYVEEKSDPQEYWSNQKLVLCEALLKVNAWREFAALSARLPTNIMPQRPAVALCNMLHALVEPLYRNNCRVAPKIIGKPISPLKSSLAPQACKTFEDMKETVIPALVLLGPSLHYDPILMYKIIRILRTARSQKEDPLHHEALTVLDAAILPALTLMDGNCCMAEEVYTLLKLYPYQCRYCLYSRWKNEAAERIPSLMRVRGNSLQRIKHIMKRVSKENIKPQGRLIGKLSHAAPTLIFDYMLLQALAAFAGAAFKKHNIELTALLQFVANRLKAQQSQDLLILKEIVQKMAGIEAAEEMTPEQLEAMAGGELLKGEAGYFSQVRNTKRSSARLKEAIVGNNLDISLCILAAQQRHCCVWKEYDADSVSSSEPPGSQLKVVGRLADQCQDALVQLGTFLASSHAPDEYAARLPPLQELLRDYHVDADVAFFLHRPVLAQKINAKVEYLRKLSDSKSDSIEKSIERYTQASQEALEPIVQSVTPILPNKVWEDISPEFYVTFWSLSMYDLRVPEESYDKEIDRLKTAAANAAKDTSQGTKGKKEQDRFNALIDKLQLCLFPRCVFTPADALYCAEFVHTVHSLRTPNFSTLLCYDRLFCDITYSVMSCTEGEAARYGTFLCKVLGTAMRWHADKQAFHRECAHYPGFVTKYRVSNQFTEANDHVGYENYRHVCHKWHYKITKAMVVCLDSGDYVQIRNALIVLIRVLPHFPVLTKLAQIIERKIDKVKEEEKTQRQDLYVLATGYSGQLRNKGPTMMRESDFHQVVDKQKVAGVPAAAPPAAAKDDASATKPDNEPAPSPPQIVDVEKKDSRNNDRRREEVDREKESKRESRSALKERSKEEIRSKDRSPRERSHREERYLETVSPPHDHRSAPDDVERDVKRRKVENSGNGKGSKDIEERSPEKEKRKAKLRGDERKERKMNRKRDRAEESVMLEQKRRRDEQKVTKMGSHQNGSQEDHHYEKYHKREKSPFRDRSHEEPRDSLLDGLMNRKYEDECCRRFTWKNKQLWYDFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G240</accession>
    <name>A0A835G240_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000746">
        <property type="protein sequence ID" value="KAF9405411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G240"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF147">
        <property type="entry name" value="EG:BACR7A4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Clip" evidence="7">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="141"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="405" mass="45255" checksum="7443F93D33F66BED" modified="2021-09-29" version="1">MVYDHVKNEPCVTGGLNGTCVGVFRCPTASLTYLYANAGYIKSPDTIYDYPDLPEICSYKNKEPVVCCTDCNISKDEPFRHTSIGPLGIPRDNNGPIAWSKCLDYLKDLPYPCRGVGNFQVKKIWKGDKKCHVYQLQYALAVGGRDAQRWEFPHMALLGYGDDENSAQWLCGGTVISERFILTAAHCISTKALGNVSYAALGLLKRTDPKELWNIHKIKRIIPHPEYSAPSKYHDIALLETETEINFGKNLLPACLDTGTNKENTAEASGWGRLGHRESLADTLQVVVLQKFDDATCAAHFPPHRNLRHGYDSEKQSCYGNNGKIMDTCEGDSGGPLQTNQFNCQYTVVGVTSHGKNCGIPGSAGVYTRVSYYVPWIESIVWPEETEERKKQDNLWLERWLNVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2C4</accession>
    <name>A0A835G2C4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000708">
        <property type="protein sequence ID" value="KAF9405629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2C4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13532" checksum="F88163A66F6E376F" modified="2021-09-29" version="1" fragment="single">MQILLEPFRNKYGSPHYSSGVLQIASARGNKELSSGFTDYSNKVLFGGPIMDLQCHDTLLSSKILTNERWGDDYHEYSVRWAPDRITLSVDGVEWARVEPTASGLRGRFPAQCTQLPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2L2</accession>
    <name>A0A835G2L2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2L2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="2">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="228" mass="26772" checksum="9201DE89A8CC30BF" modified="2021-09-29" version="1" fragment="single">YEALFPEFNSEGDDKIRRSVTKNVQQRWKTARDAYMCCKNFLKNTQEVKKKVYIYFEDMKFLDKKHQAEVEDSIESNQATPSAINQDIPSTSNQHVPSTSSQDIPRSTGLERKRKQTDTDEFDKEMLKMFKDNAKLFKNDDMNFFMSLLPITEKFTTHQKLIFRTEMLKKAMEISNIHNPYEITSRPNSSDSYHSQQSESILRSQDPMNVHETFPDMSNTVSQECVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3J0</accession>
    <name>A0A835G3J0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="2">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010001031">
        <property type="protein sequence ID" value="KAF9404266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Lysidine-tRNA(Ile) synthetase C-terminal" evidence="9">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="423" mass="49917" checksum="A582E628BB138625" modified="2021-09-29" version="1">MQTAAKKDQLNLAVAHVNHQLREESIVEAEYLKSYCQEQKLPYYYKEWTAIDKTTNIEARARKFRYDFFAETMNKEEYSSLFTAHHGDDQAETILMKLTRGSSLKNLVGIKDRQPFASGDLIRPFLIFSKERLEKYAKQRRIMYFEDHSNQSDKYVRNRLRHQVVPVLKKENPQFLQHIADFSEQIHLADDIIQSVITPKYNGWVTKTKTGWAIQLLELKAERRSIQTFFLTTLFQKTLIPEGITINQAQIQQFLIILNQSAPQLTMDLENGWQIIKEYDVAYLTKKQSDQKEQEFYLYVNEQIFLSESEWLGLESSKNKLEQPDVVKNWQEFSLLITAETSLPLIVRHRKAGDRISLTPDLTKRLNRLFIDQKIPNLQREQAWVILSSDNNIIWVPQFAYSHLSIPKETDKILYRLLYKIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3N9</accession>
    <name>A0A835G3N9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P4-ATPase flippase complex beta subunit TMEM30A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000570">
        <property type="protein sequence ID" value="KAF9406614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3N9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40456" checksum="B9C1D05EC6480875" modified="2021-09-29" version="1">MATSSETSEQNVKSRRPAESAFKQQRLPAWQPILTAGTVLPTFFVIGIAFIPVGIGLLYFSDEVKEHVIDYTHCLKEGENITCADYIKRTSMQHCSCRLPFNLTEDFKGDVYFYYGLSNYYQNHRRYVKSRDDSQLLGRLSLTPSTDCLPFAYAMEDGKEKPVAPCGAIANSLFNDTLTVFSHISNSNVPVLRTGIAWESDKQIKFRNPPGDLKTAFANFTKPENWRVNVWELDPNNTENNGFQNEDLIVWMRTAALPTFRKLYRRVDHKELGYSTGLAKGSYELIVDYNYPVTDFDGTKSFIISTTSLLGGKNPFLGVAYVVVGTLCLLLGIVLLVIHVKCSKSTTEMINVNPRTPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3T0</accession>
    <name>A0A835G3T0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000558">
        <property type="protein sequence ID" value="KAF9406705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3T0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="232" mass="26682" checksum="5B1A23F7C5DCDFB2" modified="2021-09-29" version="1">MEVDHSLLDKLKLYGVGQRKLDDVLFVNDKPPPRLGIYDFDEEVFCHDLVISTCTIPGCSFKTETLLDFENHYNDAHRYSCAQCKKILPTPHLLDLHIQETHDSFFAVLSEKKPSYSCYIQECPLKFMTANDRLQHCVDEHKLPKEFRFDTKPCHKGKKKGKSKHSTDNNDQSMEHDGESSGNVKKKVVLTTSKNRTFAKYCGKKFTKNDTKTSKDVNMDEVMADLKESLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3Z6</accession>
    <name>A0A835G3Z6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPARC/Testican calcium-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000662">
        <property type="protein sequence ID" value="KAF9405926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3Z6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16231">
        <property type="entry name" value="EFh_SPARC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000234">
        <property type="entry name" value="Protein BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001999">
        <property type="entry name" value="Osteonectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00613">
        <property type="entry name" value="OSTEONECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032803503" description="SPARC/Testican calcium-binding domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SPARC/Testican calcium-binding" evidence="8">
        <location>
            <begin position="188"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="324" mass="38063" checksum="39FAD9CF292B058F" modified="2021-09-29" version="1">MRGLLVLALVVAVLCTVDAERHRRRHRRLRTTTTERPAPPELAVPVREDSEAEHLELGMAERLDERRFQDAERSRVNEIMNEASSREGIGSDNEVNVLDGKYPCLRVHCSAGRVCEIDEHGDAVCNCIKECPYETDSRRKVCTNHNETWTSDCEVYQQRCLCLDGSELCRGPQYHHVQIEYYGTCREMPECSENEMLDFPRRMRDWLFNIMRDMAERRELTPHYLKMEREAESNLTRRWTNAAIWKWCDLDAHDNDRFVSRHELFPIRAPLMALEHCIAPFLDRCDEDDDHRITLAEWGKCLQLDEYELEDRCDEFTEDPPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4H4</accession>
    <name>A0A835G4H4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_013904</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000763">
        <property type="protein sequence ID" value="KAF9405309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4H4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="577"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9405309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="970" mass="108253" checksum="C0A253B9686379DF" modified="2021-09-29" version="1">MVWLCNHYWRRFICVWRVSSFAAGAAIFCDITVLGVDPRTCLLLKRTKNNDEKFHNWSVYRQKRGRRIVMRESVQESSNVVFREGSARWCGAMSQVAEDTDDDGDAPYISSDESAHGVDLAERLRVKPSPDIWELDEIEYNLRHLPLAEEISATVATGHYDETIEIAANVEDGILTAALWACWHGRSSLLSKLLKLGLDPNRTDEAGRSCLHLSCLVGSEECAKLLLEHGANPNMWDSSTDKKATPLHCAASAKSLACVKVLIAHGADVNAGLNERSPLHYAVLSDAPVVVKALLEAGACPDTPQVFTETPLHVAASLGSATCTKLLLDAGADVRAALGAGRATALHLAAEDGHAECARLLLEHGARIDLPNGRGQTPLHLAALAQSLEVVELLVCKRADVRVRDGDGRTPLHGAIVRGARACDVARTLLSAGADPNASDNFGYTPLHIAALNEFSACVLLLLDYGGDVTLRTNGGVSALSFIVRRVPDVIPRYLGKLDEAVHVSEHEIGDVDCELVIDFRPLVPCLSRGEAELLLAFIEVGRKDVLKHPVAETFLFLKWRRIRKFFVMSFIYHALFITLYSLYILQIFLCESRTCHVPTYLRPVQYLIILLNLCFLSKEVFQACLDWSAYIRQWENWLQCLIIIGVFLCTIPSWDNGEIRTNTSSWQHDIAAITIFFCWLELMMIIGRFPTFGLYVQMFTTVTVNFATFLLAYSCLLIAFGLAFSVLFSNYAAFKLPASLVKTVMMMSGELEYEDIFYSNSTTESDYPVTAHGMFLIFVLLVTVILTNLLVGLAVSDIQALQESAGLDRLVRQTQLVAHLESMLFSSLLTCAPKQLLGIPKDLISSVYKMVASRKIIQKSIKNNNNYVFRLKRCKDEEDTIKQNQVKRRSNLFDRYSVESQQVERRKKTNSTSNADRVRPESLNINAIQEICMVDIKTQLLELTKRVNKLIDTTETRLQRIENKLNHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4I2</accession>
    <name>A0A835G4I2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000511">
        <property type="protein sequence ID" value="KAF9407062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4I2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="61" mass="6946" checksum="4D909C55B312CD0C" modified="2021-09-29" version="1" fragment="single">MFLMVRRSNQFGNIVVFDTGPKLGKPVSWARVSTEDLSFNNLVHTVISLSCYGFRKYLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5G7</accession>
    <name>A0A835G5G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000561">
        <property type="protein sequence ID" value="KAF9406677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="588"/>
            <end position="589"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9406677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="608" mass="67500" checksum="9A20B06FEE70DE59" modified="2021-09-29" version="1">MILAPEDCGCPIVEEGPSLVNSPICSGNFLFMVLLQSYLWGRCSISTPCKRIESVEETEQEYDFIVVGAGSAGSIVAGRLSENNTYKVVLLEAGGPEPLGVRVPSFYRTFWDNPAVDWQIRTVPADYCLDQEGLGCKWPLGKGLGGTSQLNGMMYHRGHHADYTCDWVEAGAKGWSWDEIKPFMDLTEGNKQIGSLVDGKYHSDIGPLPIQTFRYQPVALYDLMDAINQTGLPLIKDMNNPNTPEGFVIAQAFNDNGQRYTTARAYLPPQSERPNLNIKLHAHVTKVLFRRKKAIGVEYVDENGNTKVVKARKEVILSAGALTSPKILMHSGVGPKETLEPLGIKVIEDLPVGKNLKNHCGATLYFILKKVKNTQVLDWSALTEYLLQNDGPMSSTGLTQLTGLLYSSYAKKELKQPDLQFFFNGFYAECSKTGAIGEPAIECPNSGYNVSANAVYLLPRSVGYMTINSTDPFEQAIYDPNFFSDPVDMEVIKEGLDYLRQIFNSELLQEQYEIELDPTYTEKCDKVAPAWSDDWKECMIRVHTDPQNHQLGTCAIGKVVDPELRVYNLKALRVCDAGSMPSQPTGNPQGAIMAVAERCAHFIKEAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5Z9</accession>
    <name>A0A835G5Z9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000554">
        <property type="protein sequence ID" value="KAF9406736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5Z9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033041">
        <property type="term" value="F:sweet taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009318">
        <property type="entry name" value="Gustatory_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06151">
        <property type="entry name" value="Trehalose_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28486" checksum="3560ADC8B713459A" modified="2021-09-29" version="1" fragment="single">TGVGFPIEEFVYRYVTLSHGFLLRAQDYSPWNGIPIFILSKLATVLWNFQDLIIILISMGLSSRYKRLNLYVRNVVTVEKRSEAKPKFGTDLYLQIQVWRRLREAYVRQSTLVRMVDRKLGSLVLLSNINNLYFICLQIYLGIHKPSSSTISRCYFLFSLSWLILRACSVVIAASDVHLHSQRALKLLHSCPSANYNIEIKRLQYQLAHDFVALTGMGFFSLRRELLLEVAAAILKYELVLIQYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6E7</accession>
    <name>A0A835G6E7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000515">
        <property type="protein sequence ID" value="KAF9407031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6E7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="65" mass="7663" checksum="1EDCBD31C683170D" modified="2021-09-29" version="1">MSEDQEHIDQGLHAKTICPWRLEPSGYEHRLDLFETFDAQHCGRKCKNDDRLDIKAIVLRGQRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Q5</accession>
    <name>A0A835G6Q5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_014563</name>
        <name evidence="4" type="ORF">HW555_011570</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000355">
        <property type="protein sequence ID" value="KAF9408884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000863">
        <property type="protein sequence ID" value="KAH9629552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Q5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12366">
        <property type="entry name" value="RRM1_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12369">
        <property type="entry name" value="RRM4_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034203">
        <property type="entry name" value="RBM45_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034208">
        <property type="entry name" value="RBM45_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="115"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="407"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9629552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="53240" checksum="2A9CF99F91900179" modified="2021-09-29" version="1">MSTGKPRRNEDGGSEDSPPYSRLFIVCERRLTEEDFREAFSKFGSIEDIRIPRNHATGQSKGVVYIKFSKTSEAAHALEAMNRKSIKGYARTLKVMVASSRSDIHTEDNNENKYKRLFITVPQVITEKDIEDAFSQFGKVVSVVIQRDRATGNPKGFAYVSYSKFSEAATAFEECDRKYRAIFAMPKDSYVRRPESIFDSNVNELINTPSCSNAALVSMMSTPAQGYTRVNFMCCPNLTRMHLENLFDLIPGLVDLQYFVDINRRCGKGLASYSNPVSAAYAVEKLNEFEYPPGLKIFVRPEISRFDMHNQNYNKLSNAAYNLKKAINSAQSPNPDLAQLTEAIGEASRLLKMATTGVTDDIAPDTNDLSYCSVKLPPPQPLADIDSDVAKRCFLVCQPQPPPLTVLRDIFCRFGNLINVYTLPNKTVGYARYANSKSADDAINVLHGAEVCGVRIKVLEADDEKTPKKRRMIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7H1</accession>
    <name>A0A835G7H1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000256">
        <property type="protein sequence ID" value="KAF9410600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7H1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22202" checksum="89172CB57495966D" modified="2021-09-29" version="1" fragment="single">LICLLKDKVDLFNVELLRSSTKEYRNKKYYCQKLFNVYVDILYCCAICNNVFKTAILFQAVDMLYHNLVGIQILINVCAWLKYNSLPGIAYAVILYAIIWIVKSLTLQITLTLQCEKFYIATEQVNDSCGIILNTRCSVNEKILCKNIKRHHKASFEKINACRLFNVDASLSFSLISTFTNYTFVLLQFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7L6</accession>
    <name>A0A835G7L6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000997</name>
        <name evidence="2" type="ORF">HW555_011144</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000312">
        <property type="protein sequence ID" value="KAF9409521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7L6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="28381" checksum="5255550D0F489099" modified="2021-09-29" version="1">MTQIAEVLSNQKSLEERFTPLEAMFMQKMEAVQAQIQAAGPAKDTIAKVAEEFRTFRELMFSLLGLLRRQITECSRQIDDMETRSRRKALIMQGIPEKEGEDCTGLVLDVINTKLGLNFTTTSIKACHRLGQTSADHHRPLLIRFASVDNKLSVWRAKTKLKGTKIAIREFLTKERQNAFLKARQHFGLRSCWTQDGIIHIKAPDGSRYKVTSTVELNPILTKYPRMQGASSSGAKRSAEETVGNLKSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G830</accession>
    <name>A0A835G830_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA and cache domain-containing protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000289">
        <property type="protein sequence ID" value="KAF9409923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G830"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF66">
        <property type="entry name" value="VWFA AND CACHE DOMAIN-CONTAINING PROTEIN CG16868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="Sensory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032339073" description="VWFA and cache domain-containing protein 1-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="134061" checksum="E3B2004DA5A43BD0" modified="2021-09-29" version="1">MKVLSLLFMITTSCGICLILAQSDNCTRTNNRGDYILCVRKLSETLASKFSEIVVKELGSEYTTRFEIRTAYKVSRYQTSDSEVLTSIAEKLSYKLSAATNILRHMNNVISDNSTPSFTHPCPFNSIRKSVFIKSSNVYDTLPSQDPKNNMLGRFKDLKVKRQYFLSHMDYATDKDCATMPHSNLRYLYHKIVHPEPKLVVFIIDNNMREGPLQHAIHVAKETVYALQDSDLIAVKMTNMTEFLKFEDTCSTDGISDIGNATENNKLLLREYLSSIDIAPNNMSPVSINTELKNLLLQRDLPKHKLFIFLTDTKVLKNETWLKIFPYSANRDESLKFAIGLIYENQADKNSSLGILHIDKWHTHTNNHSVMRLHINDSGVVGQVASAFISLLPGHYGSKKIKIEGPVWEATERDFMISLVLPTTTGVLGLDLYWSDLAEDIVYFKGSNQKKRAFVMDFSGTVLMHTFFPRPESASDKIKFTKLESVETYTFISTVKQEMLANSSGNLTMYEQNSTKSIIYSWKWVGNLYIVCIVSEVAEPAVFNKTNIFFTRSNKEILFHRLDLFPPKMGKMCRHFKQIATIDQGTVYLSPSSFQSPFTYLYDMGDGQEAVTYMQNYLAYLKSVAHGLLSNPGLKNEIQQDVGFLNSILSYYKRQHLHGPYSKYIVRRYAVTESGVMVMFPGTVLEYDYEPVRRPWYTYALENPDKIILTPPNLDVGGAGYVVSISYAVKSSFYPTMVVSMDVTMGFLYKLLIDSLPLCAMSYVKCFIMNNKGYLVSHPGLMDPNSSGPIEQQHITHKESMIAIDMLNHKGFVTKRLCNNFYDKTIQRFYEFNTSLPNVLSNVVSGDHCIHYYIAAIPGTNAFIGLVNASCNVGAFCPCSMVDRLCLNCNRMEQTDCECPCECSSELYECPNSNASRYNLEMPLCGMMLENNNHKSHYFHNFAENLKSCFDFQCETYMSHSSCLGVVGCEWCQIDADGRTPLSAPFCTSQSTCFNGVLGAVTPYGEGTLGHINRDAFGNYSAIGPIAGCIVTASLVIAVAIYCYRQNVTTASCHNLYVDGPAETWHDADVQMSHLQSDDMHDLSGQDKLLPAMEIEAPISPYRVVTGYRRPHTAGGSDHGYSTMTPHEDSEATGFSVNEPIVLSDDTKSDISCPLPAKIKPRLKANDLNVTVLPCGKNSIIAPVTVHRHMEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8B0</accession>
    <name>A0A835G8B0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HF086_015006</name>
        <name evidence="19" type="ORF">HW555_010713</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000277">
        <property type="protein sequence ID" value="KAF9410101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000782">
        <property type="protein sequence ID" value="KAH9631021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8B0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9410101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9631021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="129" mass="14777" checksum="9376CD9D8C08E419" modified="2021-09-29" version="1">MTLFLQQIKEQLKTLKMSRFRFGRQHDGYRLVSNDDSGFSDAQFEVPPPKIPWKAISLAAFLFVVGTALLIAGSLIVTGHIDTKYSDRLWPMIVLGCIMFLPGAYHIRIAYYAYKEYPGYSFSDIPEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8K3</accession>
    <name>A0A835G8K3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="5">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000339">
        <property type="protein sequence ID" value="KAF9409107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8K3"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000045">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="337" mass="38693" checksum="13CD3899D38A40C4" modified="2021-09-29" version="1">MANRSGPARRVPETEATINYVQCDGLAVMKIVKHCHEESCSNMEVAQGALLGLVVENRLEITNCFPFPKHDDTMDEEEYQLDMMRRLRRVNVDHFHVGWYQSADVGNFLSQSLLESQYHYQTSIEESVVVIYDTKKSARGFLTLKAYRLTPQAIAMYKEGDYTPEALRNLKIGYESLFIEVPIVIRNSPLTNIMMSELSEMIPEEEGSKFLDLGTASVLEGQLRSLMERVDELNQEAIKFNRYQQLVVRQQQDKHRWLAKRTQENLARAAKDEPPLPEEDVNKLFKPHPVPPRLNPMIVAGQINTYSQHISQFCSQSLAKLYLTQALQNAKESKQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Y8</accession>
    <name>A0A835G8Y8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010724</name>
        <name evidence="15" type="ORF">HW555_012815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000515">
        <property type="protein sequence ID" value="KAF9407034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000278">
        <property type="protein sequence ID" value="KAF9410093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Y8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9407034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9410093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="304" mass="34482" checksum="B8ACDB955CE47140" modified="2021-09-29" version="1">MARVHTVPQILHFFLYFSFILCCFTGFVSANRELNEDNWREILEGEWMVEFYAPWCPACNALAPAWRELSTRATRKALGVRTAAVDVTKSPGLSGRFVVTALPTIFHVIDGEFRQYKGPRDVESMLGYVEDQRWKQTDPVPSWKAPHSIQMTLVAEFFKLSQALRSVHNMLMETYGLPTWGSYLIFALATIFIGALLGLILVCIIDLLYPPRRSDKVFVSQKELDKRARGDQDAKEKSDDDQELINDDIVDDDENANNSDAEKNSQSDSSDEEKEKVTEGGGDSKAADPVDRPEVRKRRPRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9F7</accession>
    <name>A0A835G9F7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9F7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="18600" checksum="65ADE896031150D9" modified="2021-09-29" version="1">MNIKIDHDKIKRCSAKLCKVNIKNLEEGAAVVLRLTCKELINKVVFNFCDKLIHFRPVYDDRCITSIQSKQYYTNKVSLKQKQRTDKEQNKKNKNRSVSKNARLTHIWISFTEMKYTFKGGFEVMKSQLMFQVKEASRNVFINIFSHLWFSFCVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9R5</accession>
    <name>A0A835G9R5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9R5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="2">
        <location>
            <begin position="74"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="21155" checksum="8BF53D7E848E96F7" modified="2021-09-29" version="1" fragment="single">MEYGWSRNGNQRCVRHRAPESTMSVSSDIRFTRRKLSRPCRGCCAALASLLVLLLLAAVAVYLGHMYLVGDPLNRQTFRGSFVVSSWGVSEGEKGNDLEPKANRTRETELQQALYNLYLNSELKSCFVSADILALDSSEEGMRVHFEVSFEPIFTAVSTAEVTAVLARALTEPTAYFSKITTLPETLHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9X0</accession>
    <name>A0A835G9X0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Splicing factor U2af 38 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_008928</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000183">
        <property type="protein sequence ID" value="KAF9412616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9X0"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9412616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26957" checksum="36895200759A840F" modified="2021-09-29" version="1">MAEYLAAIFGTEKDKVNCSFYFKIGACRHGDRCSRIHNKPTFSQTVLLQNLYVNPQNSAKSADGSHLVVANVSDEEMQEHYDNFFEDVFVECEDKYGEIEEMNVCDNLGDHLVGNVYIKFRREEDAEKAVNDLNNRWFGGRPVYAELSPVTDFREACCRQYEMGECTRSGFCNFMHLKPISRELRRYLYSRRKGSRRSRSRSRDRRRRSRSRGENRRRDPPRNSRSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAI6</accession>
    <name>A0A835GAI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000177">
        <property type="protein sequence ID" value="KAF9412827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="521"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="784" mass="90080" checksum="720B08297C957B82" modified="2021-09-29" version="1">MKISELILIVQYLEESGWSTFFPECYFDDSSLLSLVTNLYTPSDKIPRFEVEPVVSILSYENKHYVKIKQDPTTYQLASAYRNKKHVSERALNGTTQLDNTIMNALRMSRTPVETSRNYSQNKNNNGHNKDKPISQYKKWQVGRVSRKQYEIINMLWRKTKIFLDEDSTTAAYYQRHSNVSEKVMESVSVFRPPIARLPPRASVSTTTPSFIEFYYLDESDDRVKNFPSNKFQVPEHIREHQLRNDHRKFGPLIPKCFLFVLTMKKTHTTTKYSQPTNRMRRRKTRTHGSSLTGFDSLNSLTPSYKFPRLQRPQQLFKFDPLIVTKPSREMKMNVTVNTTTPAAAPIVTINNGTNTTVTTLNSIENDTCPLTTELNTTETENSSPNNKLLNTTPVEPTTAYDKIKFFEMYDKNTPLPYYDEKGRLLDVDNIDILMKRNEVNNNERKILLENVDQDISNEHSHPHKSKHAKKHIIETFKHELQSNINSIPDVNKTMKPVVLNVSDTNINMSSVTKQDMKQMLLSQSKHSDLLKYKKSKQVDWTQYPFVAAYVYEPSQVHCDAAGISPHWLITSGSCLSRHHKNPGGEGRSAFVTYCGESWWNPERVAYVKYSLVHPRFNPRDKTRRHLYNIGLIQVVTSMASACSAWSSITLMSHQFVANEEGSMANAVGWGLDRFDTRYSSNDLPKSPLMSYENQVFSDSCPGNEGYSRAKRLDEEGGVKNVYCLALPPYAGEDTDPIHGGMLLEERRPWGDQSAQYTGIWRLVPWVLDVARENEDVDAFTLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAL6</accession>
    <name>A0A835GAL6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAL6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685:SF1">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="760" mass="84208" checksum="45178A93593F27B4" modified="2021-09-29" version="1">MASTYLDKSLSSPPLFDPKIKRRFDAFTSGLLNSASGRSTYLSCWAPKRCGTEFNPINMKILAVVLLVAIAAGVYSNEEQGANMLNYDEQSMEKSDQLASRSSYGWGVVGDDDRLISSTYHEAYDLPYLINEQELTYRGNQYTNISSIRVSSNYGNTTQVVLLDGGLNENYVTLGLRSPRSAGFGCRIDIFATMKILAVVLLVAIAAGVYSNEEQGANMLNYDEQSMKESDQLASRSSYGWGVVGDDDRLISRSQKPKISGLRLSDRHLRNCKLTYHEAYDLPYLINEQELTYRGNQYTNISSIRVSSNYGNTTQVVLLDGGLNENYVTLGLRSPRSAGFGYRIDIFATMKNFAVVLLVAIAAGVYSNEEQGANMLNYDEQSMEESDQLASRSSYGWGVVGDDERLISSTYHEAYDLPYLINEQEVTYRGNQYTNISSIRVSSNYGNTTQVVLLDGGLNENYVTLGLRSPRSGGFGCRIDIFATMKIFAVVLLVAIAAGVYSNEEQGANMLNYDQQSMEVSDQLSSRSSYGWGVVGDDDRLISSTYHEAYDLPYLINEQELTYRGNQYTNISSIRVSSNYGNTTQVVLLDGGLNENYVTLGLRSPRSAGFGCRIDIFATMKIFAVVLLVAIAAGVYSNEEQGANMLNYDEQSMEKSDQLASRSSYGWGVVGDDDRLISSTYHETYDLPYLINEQELTYRGNQYTNISSIRVSSNYGNTTQVVLLDGGLNENYVTLGLRSPRSGGFGCRIDIFATVNCHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAQ5</accession>
    <name>A0A835GAQ5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_010630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000272">
        <property type="protein sequence ID" value="KAF9410236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFG/EF2" evidence="8">
        <location>
            <begin position="223"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor EFG" evidence="7">
        <location>
            <begin position="357"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="500" mass="56103" checksum="566CE90DB8D9B479" modified="2021-09-29" version="1">MYPTDDCTFFLVLARIMSGTLYAGQTVRVLGENYSTQDEEDSRLMNVGRLWIYEARYKVELNRVPAGCWALIEGIDQPIVKTCTVVASDEDAELHTFTPLRFNTQAVVKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRNMYSEIDIKVADPVVSFCETVVETSSLKCFAETPNKRNKLTMIAEPLERGLAEDIEAGAVCVTWDRKRLGEFFQTKYDWDLLAARSIWAFGPDSTGPNILVDDTLPSEVDKHLLSSVKDSIVQDIVYSVNILLQASSGVQEKDPLCEEPIRNVKFKILDAVIAQEPLHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLAKRRGHVTQDAPVPGSPLYTIKAFVPAIDSFGFETDLRTHTQGQAFCLQVFHHWQIVPGDPLDKSIVIRPLEPQPATHLAREFMIKTRRRKGLSEDVSINKFFDDPMLLELARQDVQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB51</accession>
    <name>A0A835GB51_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB51"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06370">
        <property type="entry name" value="PBP1_SAP_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000545">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000403">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF474">
        <property type="entry name" value="RECEPTOR-TYPE GUANYLATE CYCLASE GYC76C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032915733" description="guanylate cyclase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="540"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="892" mass="101671" checksum="814A2EB01B500235" modified="2021-09-29" version="1">MIEGDGMWRGARVLVLAALSLLAEPSLAAKKFNLTIGYLPCITGDLRDRQGLTISGALSIALEELNNNTSLLPDVELLLEWHDTKFDTVTATRLITDMSCAGVVAFFGPEGRCHTEAIVAQSRNLPMISYRCSDYQTSTLSNFARLEPPGAQATKSVISLLRYYRWNKFSILYEESWVTVALTLENHAKKNNMTVNHQRAVIDGYKCCEDKMTCCAPGFWYQFIQDTKNKTRIYVFLGSTSGLIEMMTAMESLHLFSKGEYMVIFVDMMTYSPKEALKYLIKTEDRVSTKLICPNTIDFKKRAQSLLVVVSSEPSSDYEEFTNKVRKYNTLAPFTFKESVFVNQFFSKFVSIYAAYLYDSVKLYARALDQIIKEETRNEPLTEAKLRSIATNGTRIVAKMIQSSPYKSITGMSIRLDERADSEGNFSVLAFKPTKYQDGDVNCSYSMIPVGHFQHQNKREFPEYKLNPRLPIDWPDSVKPEDEPSCGFLNEKCPKDDSQITSLVVAGTLAVTLFCALVVTISIYRKWKIEQEIEGLLWKIDPQEIAGYLGSGLVWSPSKLSLASGISCESKCCTQIFTTTAQFKGNVVRIKELKFSKKKDIPREIMKEMRLLRELRHDNLNSFIGAVVEPLRVLILTDYCAKGSLYDIIENEDIKLDKMFISSLIHDLIKGMMFIHTSPLIFHGNLKSSNCVVTSRWMLQVADFGLHELRACAENEFIGEHQYYRGLLWKAPELLREMDNPNGTVGGTQKGDVYAFGIILYEIIARRGPFGLTGTEPKDIIERLKRPKLDGEEVFRPNTDALDPPPEDYVVACMKDCWAEDPNLRPDFPTIRSRLKKMKSGKSRNIMDQMMDMMEKYANNLEELVTERTRLLMEEKQKTEDLLHRMLPKRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB71</accession>
    <name>A0A835GB71_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Follicle cell protein 3C-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000238">
        <property type="protein sequence ID" value="KAF9411031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB71"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032797958" description="Follicle cell protein 3C-1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19059" checksum="59E5B148A81CFD1D" modified="2021-09-29" version="1">MRGLQSWLWLLFVAWLIVMVTAESRRKTKRENYSVSAPSEEETNYDDDYEELEPCQCGVFLSQQVGIKDNNRRSRPRGPPQGEPVVTYDTDSPSMPCGVGGFKNCVSRCLDVILKYLPRAGPVICGAVERDVHREKAFLFIKNCGGEWTPTSFSAGKEFCCTDGEHHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCA4</accession>
    <name>A0A835GCA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29748" checksum="6CA19732BFA7E577" modified="2021-09-29" version="1">MDLCSGALNEFDFSLTPLLTCSGFFIMYLVEELVHMYIHYRERKNGQVAPLVRNLSVRQSRSGVGNGEKSVNNSTADLVESKKDIESHHHNGHGHSHHHSHMPMNVGDDVTSALRGLLVVLALSIHELFEGLAVGLESSTSHVWYMLGAVSAHKLVIAFCIGVELIATRTKTWLMIVYITTFAIVSPLGIGIGLLLVGGQGATAAGISSVVLQGLASGTLLYVIFFEIWKGDRTGILQFFASVVGFFIMFGLQLLTGHSHSHSHDHGHSHNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD36</accession>
    <name>A0A835GD36_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD36"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000100">
        <property type="entry name" value="phosphatidylinositol 3-kinase regulatory subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000080">
        <property type="entry name" value="Pi3K21B, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF10">
        <property type="entry name" value="PI3K21B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="287"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="391" mass="46012" checksum="8D756327E21741B0" modified="2021-09-29" version="1">MVEIGAPQKSAEESLENAEWYWGDITRDEATEKLRDTCDGTFLVRNASNKDSGYTLTVRKGGMNKLIKIYNHEGRYGFCEPFDFKSVVELVRFYREFSLAHCNSSLDIKLMYPLSRLVENEGEENMSDDTLETKFKEIHKRYVLKTKDFEGRSYKYTILREEVNRKKQALDAFKETVRICEEHLKLQEKMQAEAQPHEKNTVLENNRNLISRVHSLRKAKTELNEILKDTVTAQLLLEREIAKLKSDVTDLYKRKDRYKVWLQGRGKTDEYLHLLEDDNIHKLEELYAHREMSSWKVNCTREEAEKLLMGKPQGTFLIRPNSTGQLALSICCNNMVYHCIIFKTERGYGFAEPYNVYETLNELVLHYAVNSLEEHNEQLKTELKYQLMRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDM4</accession>
    <name>A0A835GDM4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CUT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000140">
        <property type="protein sequence ID" value="KAF9414165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDM4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="9">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="398" mass="44761" checksum="6D5C9AEDE0C58ECF" modified="2021-09-29" version="1">MRLFETRVKKQGCLQDAGRGEGRVRRAGVLQSPARPRCRRPRAMDEGRARDRAPLTVIVAPSNASPPRLSPADLLPDGDAAFHPLSAVNGRLTPPGLEPASYATLTPLLPLPPISTVSDKFAYHAGGTFTVIQQQQSYASLSPTPYNEPLSPQSAYSRRSASPNSFERRSPTPPLPSPGLDLNAALLAREEQQAQQQQQAQTDTEEINTKELAQRISGELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAAAQIPQRGSCKRKEDLGSDMPSPKKPRLVFTDLQRRTLQAIFKETKRPSKEMQSLRTVGNFFMNARRRSMDKWKDDDAPSTDLDQQCEPHDLDRVPSLDSAESEEDHDDHDDHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE23</accession>
    <name>A0A835GE23_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_014074</name>
        <name evidence="12" type="ORF">HW555_008547</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9413105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9639210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="20421" checksum="6BF1F0524D3C3DEE" modified="2021-09-29" version="1">MSKITKSAVKWAELEKRVPPEQINKFFAFKAKSEAYFRRMKLSPPEPPKINWDEYQKLIPIPGLVEKFKSQYTSFKVPYPEDKFSAEVDKQWKTLEQDIAKYSEEMKAHISKAEKEIAAINALPKFDDMTMEDVHDIYPEIALQPVKNPTFWPHTADEQLDYKDPTQKIDIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GES5</accession>
    <name>A0A835GES5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_008054</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000149">
        <property type="protein sequence ID" value="KAF9413851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GES5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="318" mass="36255" checksum="50A8ABC2B610E805" modified="2021-09-29" version="1">MAQSQFSLLWDAHKKNICHGLSSLQQNGEFVDMTLAADGHLVKVHQVIIALASPYIKELISTAQCPHPVIFLNKISYQTLCSLLEYVYTGEVLVSIENLNELLEAGKELHIKGLEDMKLNDTSTQQVETPQNENETDCNMESLDEEISYFEITKDAEDGTKYMTNIIVESENGTRILDATAPEENFDEEPDDEDVSNDKTTTESRHNISTSPNLSVMQFTVSNQGSLQMILNRYMYYLKYTNRKNMRQWRCVDYLSSIKCPAHVFTKDDIVVQRISAHVHPFHDKRILKKVKAGAVFSAIHEAEQQQIMKRNDTNISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFE0</accession>
    <name>A0A835GFE0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFE0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="166"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="427" mass="49320" checksum="AB5DB028262832D1" modified="2021-09-29" version="1" fragment="single">HKIQDRTQRILALVPVEHAPSDTSDKSDTNSDNELPPPSPSPVSSSAPSINSSLERLNINSSPEPETTQTEGELLETSDIFHVKPEASLQLTPVLHKICPDTPSREPNYDSVPSLSSMISSPMPGPSSTRIRKTRAQKDKKKGIFRHPAIIEETHEASVDFPDDAPLNYFYLFFSEDIFTDLVEQTNMYSVQQTGKSIQVSEDEMRDFISMHIMIGIVEMPCYLDYWSNKFRYGQIADICRFLHFNDTNLQDLDRYYKQKNENKFSVDEMMIPYKGRKAGNRKQYMKDEPNKWGFKNYVHAGVSVMIYDFILYAGEDTFRSYTFTEQESSLGFGAQIVIALARTIKKNQQLCYVTIFSHPQSSFIHRSARLTSPIRFDNIGHYPSIKEDMGRCKYCQKKYNCVLFIMQYETLFCYREKSPQLFFRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFI9</accession>
    <name>A0A835GFI9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">xanthine dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HW555_007699</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">BAW_Kor-Di-RS1</strain>
            <tissue evidence="24">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="21">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="21">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014309">
        <property type="entry name" value="Xanthine_DH_Mopterin-bd_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02965">
        <property type="entry name" value="xanthine_xdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 21" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10 20" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 21" id="KW-0408">Iron</keyword>
    <keyword evidence="13 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 21" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="23">
        <location>
            <begin position="259"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="1296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="947"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="949"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1045"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1114"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF9414385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151381" checksum="2DEF59A3A64D2397" modified="2021-09-29" version="1">MGLLNLEEENGDICTELVFFVNGKKVVEPNPDPEWTLLWYLRKKLRLTGTKLGCAEGGCGACTVMISKYNRKEKKVHHLAVNACLAPVCAMHGLAVTTVEGIGSTKTRLHPVQERIAKAHGSQCGFCTPGIVMSMYTLLRTNTKISYNDMEVAFQGNLCRCTGYRAIIEGYKTFIEDWETQRIANTTNGASNGEPNSQNRVCAMGKDCCKNKTDKDEEPSETEYIFDKSSFLPYDNTQEPIFPPELKLYSVYDEQSLLYKGQKVSWYRPKDLNTILKLKNKYPDAKIVVGNTEVGVEVKFKHCVYPTIIMPNCVPELNAITENENGLTIGAAVTLMEIENNLRKYINDLPKYKTRSFVTIIDMLNWFAGKQIRNVAAIGGNIMTGSPISDLNPILMALKVKLNLVSEDGGHRSVLMDETFFTGYRRNVVKPNEILLSIELPYTNKYQYVMAYKQAKRREDDISIVTAAINVEFESNTNVIKYINVAYGGMAPVTKLASKTGESLKGEKWNEAMLDKAFSSLIEELPLNPSAPGGNIQFRRTLTMSLFLKAYLAIAKQMTKDYIHEDLILPYHSSGAEQFHGDIPKSAQYFDLVGDEQVKSDAVGRPLTHMSAFKQTTGEAIYCDDIPAAEGELYLAFVLSTRAHAKLLSVNPEKALKKPGVVAFFSAKDLTPEQNAIGPIFHDEELFASEKVVSQGQTIGVIVAKDQAIAQEAARMVEIEYEDIHPIIVTIEDAIEKNSFYPQFPKTISRGDVQKAFDDKSNIIIEGQCRMGGQEHFYLETHAAFAIPKKEDDELEVFCSSQHPSEIAKLISHILHVPMNRIVARVKRMGGGFGGKESRGMLVALPVAFAAHKLQKPVRCMLDRDEDMMMTGTRHPFLIKYKVAVTQEGKLMGAQVNIYNNGGYSIDLSGPVVERAMFHYENAYYVPNAEVTGHVCKTNLPSNTAFRGFGGPQGMFGAENIIEDIAFKLGKSSDEIRRINLYKENSITHYNQSLENCTLQRCWDECIEKSKLAERRQFIEKFNKEHRWRKRGIAIIPTKFGIAFTEKLLNQAGALVLIYMDGSVLLSHGGTEMGQGLHTKMIQVASRALGVDVSKIHISETSTDKVPNTSATAASAGSDLNGMAVLQACETLAKRLQPFKEKNPNGKWEDWVLSAWIDRVSLSATGFYATPNIGYDIKTNTGTPFNYFTFGAACTEVEIDCLSGDHQVIRSDIVMDLGESLNPAIDIGQIEGAFMQGYGLFTIEELIYSPNGTLFSRGPGAYKIPGFGDIPQEFNVSLLKGAPNPRAVYSSKAVGEPPLFLASSAFFAIKEAIRAARADAGVSLEFRLDAPATSARIRMACEDHITKKLDEPKEGTYVPWNVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFJ8</accession>
    <name>A0A835GFJ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFJ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="332"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="570" mass="63370" checksum="0D6F47B471C37EB9" modified="2021-09-29" version="1">MFETNEIEGLFPEDEYENHLTITNKSALQQLQLSFPSGSNMTTNVLLNDVWHTNQELMTADAINHILNSANNILQNADTSQMKTWRSSLSNYDVQSLVQKTIENCEQCNSSTKEDISQFLKNKCMCNLGITETDKSSKQAQTTDMKSNSYFVKNLNVDSSSQESRSGDDQKQVFKPRFGRPKPNKAVGHPQPTISSTPIAEEVNFEKEEEENKAHKSNVAKIMFKTAKETLLASNPAAKRTLGTSRKAQAKFVSPMIGAQDKQETVEPEVTDERLKHIDPKMIELIESEIIDKGTPIGWDDIAGLHLAKSVIQEAVVWPLLRPDIFTGLRRPPKGILLFGPPGTGKTLIGKCVAAQCNATFFSISASSLTSKWIGDGEKMVRALFAVARCHQPAVNEIDSLLTQRSDTEHEATRRIKTEFLVQFDGAATGEDDRLLIVGATNRPQELDEAARRRLVKRLYIPLPDADARKQIITNLLTNETNDLTAQHISEIANLTEGYSGADMKSLCSEAAMGPIRSVPLSQIVSIDRNKVRPVCIQDFINALQRVKPSVSQDDLGQYVKWNTTYGQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFY9</accession>
    <name>A0A835GFY9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040126">
        <property type="entry name" value="STOX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437:SF0">
        <property type="entry name" value="FI21431P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22437">
        <property type="entry name" value="WINGED HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="737" mass="80315" checksum="E9FC56735D2773F7" modified="2021-09-29" version="1" fragment="single">NPNDKILYGRPNKRRSASFPAPRSLDRRNSLRIFGSSSKYLQRCASTRSLHHKNANTTDSSSSTDYPPSVESASPKKVSLLSRLFRRSGRSKQTRAMSTFSAQFPPTEWFNSKAESLQSQTSFVSSYYDGSEISNRSSTLPRRHKRHLSTESGLAGSHYDHSPVRHSSPSSGSLPRSTLSRSSTNKTILDHFGSPQRNSDPKLRDSPSGSLRRVDYSNSDHIMSTSGPSSLESTTTQRTPRKDAKNGQLDQNSPMKRGYNTSGSSGHSSLESHISDRTLKPSPSHSNAHGAPGLSRAQSLVKVQSLQSSPKSLHKFRTKPPMVGGETVKNGNTSPKSSPKNCPSTPKKTATPLHKTLGSKVENPSTTMLASSNSNNSITLKVTTNTISQNGGGTNTKVYVQNSPVRSVITFENGKVTETSNGSNIYIINDDRQVVSVSQNGVQNKTAKNPTETSFDVCVEKNKQMYQEEPVKVQENKFNKNSINDAGMNNNRKLSLQIGGATNNNSFVYKNQLNNTNEVASNPASPAIHNNINNLESTANSIPSTPTKSYDNIIGSLGSLRYQKNSLSSANSGIQTNINSNSELKSVDLLKKAAALQMLNGLPNVNNRVSSDSIANMLTKAIDQKPTVLGSEPNLALKNQEPIKDINTSVEKLNCLENKQKRYSLSQESKKENQDFYNFPSLSDLSFNFTSLAAQKILKGVSINSVDTLVELNMAANNSEKQNNRDVAAVCTDFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGV7</accession>
    <name>A0A835GGV7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="210" mass="23877" checksum="0C095FFB28F68DD1" modified="2021-09-29" version="1">MEFTGLILPLTKNICRTCLSESDTAMFMNVQDLIEHEMIKVKLIDILVFLNCLENNDEENWPQGICSSCVSTALVAYDFKLNCLKANSTLSQILMIQSPTHLQRTEIDSIDINVVYQDHEYDVPLFSNHPTLDFDSTLSDNKLTPLPPVTEITSSEQPPRVEGEKRYSCTICNKSFTRYMVCSIIWRDIVILREIISVLNVEKASTHPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH46</accession>
    <name>A0A835GH46_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH46"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000179">
        <property type="entry name" value="synaptotagmin-5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF378">
        <property type="entry name" value="SYNAPTOTAGMIN BETA, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="86"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="33996" checksum="BC22773783E14E61" modified="2021-09-29" version="1" fragment="single">MDLIYRYVDVSKPFDQVQLKIGCPIVGLRLRLRIDRSNSLVESSSGVGPLSPGASAAISSLGALQPDLYTKREAPLVIELEGAGPSLGRIHLRLKYDFDRSDLEVHLIEAHDLAGYEAGGFNDPYVRVTLLPEVDTRVRQTPVHRNEANPFFDQHFKFPVSHDELSDKTLLLQVFDYDRFSRNEVMGSAKVPLSRVEVAGGAEVWAELSRERRPPEELQELLLSLSYLPSAERLTVVVLKARNLLPPQEGKDALDVYVKVYLLVNGKRVKKKKTNRKEINNPVWNEALSFSLPSANLQEASIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH91</accession>
    <name>A0A835GH91_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH91"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000029">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 11" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="12">
        <location>
            <begin position="461"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9416263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="610" mass="70219" checksum="9F64DD84057FBD19" modified="2021-09-29" version="1">MAISRRQILRLLRVRNLLMLTLIALLLYIVKLLNNLDAGNQFSNQALEVIRAPLRFQKDKDLFVPASLNKIDWHDYVLLEHERKRVGIGEQGKPAFLPKSESEHEKALYSVNGFNGALSDKIPLNRSLPDIRHSKCATRLYIASLPTVSVVVPFHNEHWSTLLRTAFSALLRSPSTLLKEVILVDDASTKDFLKEKLEVYLAEHMPKVKVIRLEKRSGLITARLAGAKIATSDVLVFLDSHTEANVNWLPPLLEPIALDYRTVVCPFIDVIAYDTFEYRAQDEGARGAFDWEFFYKRLPILPKDEKNMPEPFESPVMAGGLFAISRKFFWELGGYDPGLDIWGGEQYELSFKIWQCGGRMVDAPCSRVGHIYRKFAPFPNPGHGDFVGKNYRRVAEVWMDEYAQFLYARRPHYRNIDPGDISEQKALRQRLQCKSFRWFMTQIAFDLTVKYPTIEPKPFAKGRVRPVSNPNVCIDARDGEKHDRLRITDCADVVDPEQNFIFSWHKDIKVSSRNMCWDLPETASESPIKLFSCHLGGGNQLWKYLTETKQIKHGSGEHCIEWRPTTRDLFINTCDLARETQRWTVDFVDKEMMAKWTLAKTRVTGPIEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHE0</accession>
    <name>A0A835GHE0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHE0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000392">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032690092" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9417115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="386" mass="43754" checksum="C17588E9AE67D277" modified="2021-09-29" version="1">MIWICLSVVFVSESLFPRFVEPVTNVTVTVGRDALLACVVEDLRGYKVAWVRVDTQTILSIHHNIITQNARISLSYNDHRSWYLHIKNVQEVDRGWYMCQVNTDPMRSRKGYLQVVVPPVIIDNMTSTDMVVREVTNVTMVCRATGYPEPYVMWRREDGQEFNCNGESVNVVDGENLTISKVSRLHMGAYLCIASNGVPPSISKRVVLMVQFPPMLSIPNQLEAAYIGQDVTLECHTEAYPSSINYWTTDRGDMIISGNKYITSLSDDSYSRKMKLTIRRVSSRDFSSYRCVAKNSLGETDGLIRLDEIPAPSTTSTTDNNVPTFPQRKKGKHKNRWRDSSAENRVIGDYEVEEWKDVDYESTQSSRSTISRSATLVIIGCFLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHT6</accession>
    <name>A0A835GHT6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHT6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9416622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="295" mass="33398" checksum="9AE8DC4C9C1B6CB3" modified="2021-09-29" version="1">MTNAVVLFIGTLTVILINFITKIKMEDVYFAPSLFLNHGGGPYPVLGEKNNLEIAEALKNVSSYVDLSRLRAIVIVTAHREEDVVTISSAERHSLLYDYNNFPPECYKYQYNAPGDPVLAARIHEAFKSAGIESRLDDQRGWDHGVFIPMMLINPKADIPLIQISILKNQNASQHYEIGRVLYQFRKEGVAIFGSGFSYHNEEGFQRAKRENDKIIENTDFDNFLNEVCTGDEESRRKIVFWEQEKGAYESHPLGEADHLMPLIVNAGAGGTGRGRKIFESVYAQKFKISGFIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI35</accession>
    <name>A0A835GI35_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000111">
        <property type="protein sequence ID" value="KAF9415418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI35"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="397" mass="45736" checksum="61229D9226414081" modified="2021-09-29" version="1">MVMKSSRARRILGLLAENSTPDCENTITSPDYELEYEKPNNSNMNSNNEVQNEHNIPTETEDKTIAESIEHFEKTNEVAIPKTHFQHLVPYSDSDISLSDHEDTRYTTTEAENKNEENTVRQSSSTSSSSSSSSSSSSDSDSSHSTNTRSLARTARHHENSTSYYSSPIYTDESDIDLSDTDPTFTIMENRRKRNYIFYDSSSSSTSSSNSRITPKKGRKRSKKPSQWKQNKMKRLRNKGKTYISMSKTRKNVPARCLKEPCSEKCRLKCTTKINRDSRYELFRKFWDLGDLAKQRAFISASMIDVQPKYKYTNSERPRNNNKAFHFTVDNTMIRVCKTFYKATNKRKKMKALTEISLQQAYSKKLEISANKKKDLKELITKALIPSFYAGFYNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIX7</accession>
    <name>A0A835GIX7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_005153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="82"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9417856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="507" mass="55953" checksum="DFBF022D5A2E66C6" modified="2021-09-29" version="1">MIKSLASFVKLVNKNTVFLEQVRYASQALPQLSSEKYNIRRKDFGKIEPSDVDYFRSVLSEDRVLTEESDVLPYNVDWIKNCRGQSKAVLKPKNTEEVSTILKYCNERKLAVCPQGGNTGLVGGSVPVFDEIVISFALMNKIIDLDDLSGALVCEAGCVLENLDNHVRERGLIMPLDLGAKGTCHIGGNASTNAGGLRLLRYGNLHGSILGVEAVKADGTVIDCLRSLKKDNTGYHLKHLFIGSEGTLGLVTKVAIHCPVLPKSVNLGFFGVKNFENVLKLYKSAKSKLGEILSAFEMADFDSISFTAKNLKLPNPISDYPFYVLVETHGSEETHDGEKLTRFLTNEMESGLILDGTVTSEPAKMQTIWNLRESIAAAGLVGGYVFKYDVSIPLKNYYDLVPILRKRLGDKAVKVFGYGHVGDGNIHINVTVPQYTKEVSSMLEPFIFEEVSKLNGSISAEHGIGFRKPKYIHYSKDQSALGLMKDLKQLMDPNGILNPYKVLPDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJE4</accession>
    <name>A0A835GJE4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_005612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJE4"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9417210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="288" mass="32739" checksum="033B306E283E4285" modified="2021-09-29" version="1">MFPFRVTSRIWGKLAACELPTSIRSFVYGTYIKMFNVNLNEAEYTDLKYYKSLSAFFTRPLKEGARYISPSPCVSPCDGVVLNCGPADTDKIEQVKGVTYSLEEFLGENKWNKKKDDNYYNSLLNNKDNVLHQCIIYLAPGDYHRFHSPCDWTATFRRHFSGKLLSVNPWLARLIPGLFAINERAVYVGEWKHGFFSMTAVGATNVGSIEIYNDPELRTNTKGKRNRINEVDLGRVELKKGELFGQFNMGSTIILLFEAPKDFKFDMASGDKVLVGQALSTTSKEQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK45</accession>
    <name>A0A835GK45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_005984</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="JACKWZ010000084">
        <property type="protein sequence ID" value="KAF9416755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001304">
        <property type="entry name" value="DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="269"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="501"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1126"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="166"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1305"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1373"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="325"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1319"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1394"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9416755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1432" mass="165534" checksum="B46FE0011D860227" modified="2021-09-29" version="1">MSEKLVGKTVLKRHEVARPVHIQRLEAALDVRPFVGQVESILNSDVASDSDDDSDAKSFGNEMSKGDRMIHGVVTTKQERQSDRLRLYNFSSVGEEREWLRDVLLSSGSETSSDDDTPHSKEMRIRRLLKERKYHNKYAKKYYKDQGNSRYMYYGAGLLSTVDRYPERRISRPVPPPPSTRGRRGRPAERGSSTRGLHKARRGRVRDARMNEGGDMPDSADWDDQLHSLKEEPDNDEYTMSAEKPGVRGRKKLSTLKSPEALTARRRRHWLLLVKKELGKVQRARTATHREVMLQRKRLATLCCKHWRHIAMQSQKNMKETVWRCKRLSREMQAYWRRYDRAERETRRRMEREAEEQRKMDVELMEAKRQRRKLNFLITQTELYAHFMQKKMNAGDDGDCGADRILRQLDEDRDPRLAAIDHYDSEAMKARASRNAREAFRAERARTQLFDSAAGASDATDTDGGADGTDGQGRRSGDHEQPSIFRGTLKGYQLKGMNWLANLYDQGISGILADEMGLGKTVQCIAFLCHVAERLGVWGPFLVVSPASTLHNWQQEMQRFVPDFKVVPYWGSPSERKILRQFWERKDLHTRQAAFHVVVTSYQIVVSDLKYLNRVSWQYMILDEAQAIKSSASMRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSTIDEKHLSRLHMILKPFMLRRIKKDVENELSDKIEIMVHCPLTIRQKLLYIALKKKIKIEELLHYSVGAESGHNVDKNFTSNLMNLVMQFRKVCNHPELFERRDVRSPFSMQVDDYHIPKLVAEDCILIRSTPSKRHLLYNKLSILVPEYVQRSNNGELGSKEDYDDGCFAFMRFIDLSPMELFRIMLCGWLFAMQHIENCLVKYEKLRHRHSWWNSSVISDFKQEESEIDLCNDYWDRVNKKHMLLICPDGDVLRKRKEDSLLWKDLLFTDPLWIQGGPFYTHTEHVIHYMPETIEHKAMRIRNLRDSRQTEMLSEIKTEEGGVIAVPQLEVPDVPFVERPPVSYIDMPTPLPGFLYFAQQKVCTCTRQSFAVSRSYAYHETRHAQCESGAGWDTVWRLLAGASPPAGWADLQVPDKNQLVSDAGKLTALDSLLKRLKERGHRVLIYSQMTKMIDLLEEYMWHRKHKYMRLDGSSKISARRDMVADFQARTDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERIMQRAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEEIELKYRQKSEEKKMMEERERKRKLGLLPQVQQQPPATVEAKRARDSASEPGSPLQVDDDGDKLIVDVPSPAPIRAALLESDAPLEQIEPVVSGEAGAAGRGRRGPGRPRLRASAPPRASTRRPRRAREPLLVPLAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKI4</accession>
    <name>A0A835GKI4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoacetylglucosamine mutase</fullName>
            <ecNumber evidence="5">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_005025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKI4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000015">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="14">
        <location>
            <begin position="206"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="13">
        <location>
            <begin position="328"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="521" mass="57609" checksum="0D92EE2FA9EAF0D8" modified="2021-09-29" version="1" fragment="single">FSEREWYEDISVSKIKRLQKVTRITMPPSSLRVVYAFAREMHPKTTDVFIQYGTAGFRTKAILLEHVVYRMGLLAVIRSRVKNGRTIGMMITASHNLEPDNGVKLVDPDGEMLEEEWEAIATKLANVSDNDLEATTMEIIQEVQADMTLKASVFIGMDTRYTSPRLAAAAANGVIALKGTPKEFGIVTTPMLHFFVKCRNDNTYGTPTEEGYYEKIIGAYKNMRKSLPTIGEYSPCLYVDGANGVGGKKLKNVKKNFDEDELELHLFNLGGSGEKLNLGCGADHVKVTQTPAKGIPSTPYQRIASLDGDGDRLVYYYTDDKDKMHLLDGDRIATLLASYITELLQRCKTTEIQLGIVQTAYANGASTKYITETLKIPVQCVKTGVKHLHSAAHKYDIGVYFEANGHGTVLYSSKAKKVIGRIAQEGDPEPREAAKLLMQFIEMTNETVGDAISDLLLVETVLCARGMSALHWMQLYRDLPCRQLKVTVKKADTLAAEVCQAVFDLAGGVGNRTELPPASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKQ9</accession>
    <name>A0A835GKQ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_003675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="168"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9419963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="707" mass="78268" checksum="787926096E3B5057" modified="2021-09-29" version="1">MYKSFLFRRLPLNLIKHEFVSQAYIIKKAPLNNSHQWARQLSISYVCCKKRRSPEEKEAESQGRQSIRYSPKSAEVVGIWRNMTVQEIANVLNKDVDHVLKALDFADKNSDVVYTEKTVIHNPQIIRDVVKISGCRFKIVAKPEQDLGEEENKDAVPAPPAPPEALRPRPPVVCVMGHVDHGKTTLLDALRDTSVVDQEFGGITQHIGAFEVQLASGEKVTFLDTPGHAAFTAMRSRGAHATDIVVLVVAADDGVMEQTVESIRMAREADVPILVAINKIDKPGVNIERTMRALATQGIICEALGGDIQAIPVSALKKQNLDTLVEALTLQAQLMELKADPGGYVEGVVIEAQLDPRTGKQATVLVQRGTLRRGSIIVAGTGWAKVRVLNSAEGRVVQEAPPSTPVSVLGWRELPSAGDQVLEVSSEKRASEVMRWRQAQRMKEKQAADVEAIAAKDAQHQQAYAARLARKRALGRYKLRAEGPREKMIQEDTHPTLTVIVKGDVDGSVEAILDILETYDEHERVKLDLVHFGVGPVTPNDLETAEIFKAVIYAFNVDCPPALSVEAKKKNIPIKLHNIIYRLVDDVKEEISARIPKKLEEEFVGEANVLQQFLVTENKKKVPVAGCRCVKGSLAKNALYRVIRGQEVVFEGKLASMKHLKDEVPTIKRDMECGLRFEEPFDVQPGDTVVCYKMVDAADTTSWDPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL50</accession>
    <name>A0A835GL50_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL50"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000001">
        <property type="entry name" value="Carboxypeptidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032560830" description="Peptidase M14 domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="188"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="483" mass="54336" checksum="76BC0AEC1B9C25AE" modified="2021-09-29" version="1">MGSLTKTVVFLCVASSVLCTPFINQLQPGQEWPTRSSVKQPYNQAEPEPTVGGVTKNEEVDVPAVVDEEKATDDDKPIETLDDVVERIDYTGAQVWKVSTMKNNAQRLINQLASEKLIASWGGNHTSIDILVKPKALENVTAALKTKDISYYVMIEDLQQRINEENPPLDENELELQDRRGHRMTWKQYHRLEDIHGFMDYLAKTYPSIVSVKTIGKSHEGRDLKMLRISDGKPSNKAVFIDGGIHAREWISPAVVTYFINQFAENFDVESDDIKNIDWYFLPVVNPDGYEYTHKTDRLWRKNRKFGYGPSSCTGTDLNRNFGYRWGGKGASSYPCSDIYRGSGPFSEPESKAINDFFKSSAVKFSAYLTYHSYGQYLLYPWGYDNALPPDHKDLESMGKLIAQAIRNTGGSNYQVGSSSGLLYPASGGSDDWAKSLNIKYTYTIELSDTGRYGFVLPASYIEPVARENIAGVRVLARQLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL87</accession>
    <name>A0A835GL87_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL87"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="28052" checksum="7F4A448383DB1994" modified="2021-09-29" version="1">MPDAILLHKLFGEAYSEAAQQSIAVNGFLKCGIDPIDRHVFKDHDFLAADTTDVALAEPVTQQNEAHKENETPEREQSPSVLQDALEEILAMTPPLLDSQAGTLMSPIVHPQPSTITSPMLDPQPNTITSAMLDPQPSTITSPMLDPQPSTITSPMLDPQPSTSFAVMPRDLFPIPKALPKTKKINRKRGGHFARPSLTYDHLIPAAPGWNSTLKNDIRRCTSGLEAGEQLLLVIHQINAVIATILTSLDILNIIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLN3</accession>
    <name>A0A835GLN3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="83"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="380" mass="43911" checksum="743AAEA61BCDE79B" modified="2021-09-29" version="1">MSVTIKRIQPRRVKSTLRRPDKFYVYDDEESDQSSNKTLTAECADHSTQTKGNQRQRLTVQKCLITPRRKLKRGKPKLMDWKKYHRLSVIYAFIEELERDYPAICTVSVIGKSVEGRDIKMLKISNSNANNSGVWLDACIHPREWISVAVITYIADMLVKNFHTLSSAITSKDWHIIPVLNPDGYEYTHTHERMWRKNRARYGGECVGVDLNRNFSYAWGQSNGEEGSSDEPSHVFYRGPAPFSEPETVAVRDTILGSVTPFKVFISFHSYFELIIFPWGNRQDPCPDYLHLLEGGTVMARAIHETSGKTYKVGSTKDLTYYACGTSIDWSYSIAKIPYSYMVELRSKQHKFRLPKDQIIETCKEIWHAVRSLMDYVDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLQ8</accession>
    <name>A0A835GLQ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLQ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039932">
        <property type="entry name" value="Spink4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179:SF0">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="69" mass="7216" checksum="890CB4369992CF1A" modified="2021-09-29" version="1">MSPSQRQCISSCPVTAEYNPVCGSDGVTYTNPGRLTCAQMCGVSVNLQRSSPCPTPPPTVDGVPQTQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLS9</accession>
    <name>A0A835GLS9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9418992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="948" mass="105202" checksum="79D0D2BF95AA88C8" modified="2021-09-29" version="1">MEAVEEPPLQNSTVDNMKVTVMFDEHNENAVASVATDVCHKSNGVAESESAEVAPLESNSVPREESKCEPESAETSVDVKDKTQDIDKQASEAAVPKINDPTDTNVEDSRTAIDDSSSTIPEPAVIKEVVTVASEEETVLEVDNNVQVCSDRVTFQTEILIETNDNDLTETVTEELVVDDQHSNNLLSELGQSIELSEALRSSDVSDSVENNNSSVRQEVFNKEELLDILEGNNEDQSESVNLKNVPSTEMLETTIALQQLNRLKNAKKRGQNERLSRNRKSDKIEKVVKQEASHKQKASVEENLREIVKGTEENIVNVLVKEWDDEDIDGEKANKLQESENLIKNAEDSVKTQEGATKEDDQASARTSIDSSSDGKLQVLNRSSDEGAPQRRLGRVIKKKVIFDPDNPDTFTKTKSVTKSKEPSIEKDVTPLKKIKTEPTFQRTKSKSPISKLQWKKPSPKNCKQNKRLTEVDKLLMDEGAVNMIYQLTPEAPKGKKNMKTKAEFIKKIQSSTPDSKEMKFRERKKESKYEEGEAKKILGGKQRSSLSSSVKSPSVSEDFEAHSADDSIIYRRHSSSSYSSSCMSPRRLSDVESGSRNPPQNIKAEVQNQSAGESTNSQPLADVFMSDITDTIRPDAINKDDCLSIKEKLNSKLNLALNKRKREITKIDKPSKIKKVMKSDERPIVNSEDFKYLSISFDQKLAEIRIQKVGSRCNIEMLKELEKALLVVGAKKDISVTLLSSECATAYSDLDLRSLLDESIEKSANFANDIAESVRSLLQTVEQHSKLLCSGVNGRCSGVGLALIGLSDVALASERASFAISPKSHGGVAPIEPGAAAFTTYRLLPQPLLNDLIVFGRRLTASEVLQGGLVSRTLWPENFNEQVQTIVKDIAAQPARNIWLKKRILSMKKGGSESTFLGYLEKERDLLVEYWTSAEGQEILRATYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLW0</accession>
    <name>A0A835GLW0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLW0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="152" mass="17570" checksum="EF77CFABB034260C" modified="2021-09-29" version="1">MASHARGNRDTERRKILDDAARKRRARKAVEALEQDNFHEDPHADLVMSKKVPKFAETNEKPTRKKKTKSAEYYKMRFRKTFAQLVEEDASFRPDPPNYLSAQVPPSKFPDRHFCAVCGFPSNYTCIPCGARYCCVRCLGTHLDTRCLKWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLZ8</accession>
    <name>A0A835GLZ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_003371</name>
        <name evidence="7" type="ORF">HW555_004686</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000018">
        <property type="protein sequence ID" value="KAH9645698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLZ8"/>
    <dbReference type="SMR" id="A0A835GLZ8"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9645698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="132" mass="15170" checksum="C2736F4FEC3113F8" modified="2021-09-29" version="1">MTEGTATIRTRKFMTNRLLARKQMVCDVLHPGKPTVSKTEIREKLAKMYKVTPDVVFVFGFKTNFGGGKSTGFALIYDTLDLAKKFEPKHRLARHGLYEKKRPTRKQRKERKNRMKKVRGTKKSKVGAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM60</accession>
    <name>A0A835GM60_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM60"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="91" mass="10067" checksum="27323B5EDE840BEF" modified="2021-09-29" version="1">MKYHSKPSAKQNMEYIENSQGVMLLCDDVIVTQPSHTPNSSSQNKAENHNTDVELIASSEMEYVPNVKKPLIKDTGAPGCLLRRPVSSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM92</accession>
    <name>A0A835GM92_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan recognition protein family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM92"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF73">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="6">
        <location>
            <begin position="90"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="256" mass="28807" checksum="5FF62C26491DE918" modified="2021-09-29" version="1">MELPLRILNYHETRHNTNHTEEEPPAPVTPEENTPLLHRFPNNGSERNPVTTVIVSLLLVILIAGVIIGIYLLILQNDSENILPPVERPLQLVSRSQWDTSDGDQSALRSFPYRLRAVTVVQTGTERCNSTESCTKLLLEMQNNVTAVNATLPYNFLISSNGQTYEALGWLKCIPQATKNTTPTGLLLAFIGNFTETPPTQSQLQEAKNFFDTSVSEQYLHPSYRIFGKNKNDTPTHLIDSLKAFPQWSNEFSDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMR9</accession>
    <name>A0A835GMR9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_004687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMR9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9418538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="40270" checksum="9CD30906C677AE7B" modified="2021-09-29" version="1">MTSTLLVQKMMSVKLSKGEFEKIKWLRANNKEKTFKTISSLRTLLQNQKYRKTCRLCLKPGSKKMFDSNDFDIAFVIKQLLQIKVTKDDDKPQYICKACEVVLRNADQLRQTAEVTQWRLQQELELMTNMESDTEEKEKTPHGGYFVKKGTTVVREWICGKCRQTFDSQKVFMEHEKLPCSRGDKSFVCETCGLELKSMTRLKRHMLIHTGELQYPCIQCPYRARTKYALMVHERAHSGERPLTCPHCPATFLNSSNLASHKRRHLPPAYHCHVCVKSFRFKEALQNHLATQHSTAKPHVCNACGKAFSTRKMIRRHERRVHNRPKLRSGIVPTYLRQLQQEQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNE2</accession>
    <name>A0A835GNE2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="28401" checksum="6EB3074CEE292F2C" modified="2021-09-29" version="1">MSQVSYKGRAEGDSITLRSALENIQRLVPIAPEKSFAERIPLSHEMRCMLTDLLDNVVKLSRSNRKESQETRREIRGICEERMEVTLDAKHIVECIFDLATKAKVLPVKEHKYHHFMTKIYTDALQRTKEPIHATDCPKELPEAIRRKAEEEALKIHGAICLCDVDVTGSPSNPQFDVVSLPDEEKKKLLPSELREYEELKKCKCDHEAKADPEEPPVDDAMTEYTGVTDYSAFTYTDEVGEYDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNM1</accession>
    <name>A0A835GNM1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Caspase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNM1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF245">
        <property type="entry name" value="CASPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25582" checksum="EE5B19CF33D15423" modified="2021-09-29" version="1">MENHKCRLSLWAKQKAPKGTVKSQNIMKQIEQTAEMNHSKNDCLLIMVLSHGESGLLYARDTHYRAENLWSPFTDAQCPTLAGKPKLFMFQACQGDKYDDGITLKRETETDGWYEPHKNPVHPDFLLVLSTVPGYFAWRNRDRGSWFIQALYEELTYTAEDPIDILTLLTYVCQKVALNFQSETSNDVTNYKKQVPCISSSSARLPNPKEKSRVEIELSPSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNZ3</accession>
    <name>A0A835GNZ3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="171" mass="19158" checksum="E3AB63133A559CB7" modified="2021-09-29" version="1">METTLKIFNYPWKIDECDELICHQTVVDYVYGGCPGCLAGVLRGDLAETVATCTTDCVQHQDGDSYHRHSDGVDHDGLVVERCVDLAPVHRMPQRSTEALMCCPRDSGVRNLFLDKIYMTTAKMAMQATPMALMIIPSSTIPLYLSTLWIRTLTSNSYNTDTQKTRNSMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP11</accession>
    <name>A0A835GP11_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP11"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="78018" checksum="4E93608A120691C9" modified="2021-09-29" version="1">MGKEDVSAKKRRKINTSSSSDTSKQVPVDIYKRVVEFEESEAQLRPAEKDATLFKKICQDIRHLFAEISELKSKDTDEAREKINAKRIEASLNLVALKKLNRLEKVRTRAGRDALHKEKQRVDSTHLLLQNLLYEADHLNKEVTKCLQFKSKDEEIELVSLEDFFTNAPPEISRPELTKTDEHQLQLARLEWELRQRRELAAACNELISSKERVAAAIAAARSRLDALVPHLRDVLKSTKPLQECLALRLDDKRDEARAASLLPSPLFLLFANTSAYSDALGSNSVAVSISGDEDEARRLEQLSNVDSDLVASNDSDSDQENNEDDQREKKKRHHRTAKISKEEKAEAKKKEVLKKHPLNVQVSVKVQDGTALNLIFSYLLHLKIVVVKFTVTLPKPITGVSAADVLNGHCILNELYPGDTGCDSPHPATSYLLNAAGINEDFQYFISELGKPYIWAQRMCGLDFMATITEDQKINKNNNICPSLSVSTVENFILTLKKRLKSRVELMKELQDLESGKILPVKGDFLCPVRLSGSLTQWQSVGWPEYSQSPSTSFLIAEGLVNPNDMLYRAIITRQSAKLVALVALRSDYPRKAPIFSLTLHWNGTHHAGINDDIRDIERFINTDLGSEDKKQFTLSVQITKLLTCLDILLETTGSSEFPPDKVMFFPVRGRNRLKPYKFLKQGNGVFVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQA8</accession>
    <name>A0A835GQA8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQA8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="3"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="220" mass="24014" checksum="AE35F876BECB64CD" modified="2021-09-29" version="1">MPVWFQNRRAKWRKKEHTKKGPGRPAHNAHPQSCSGEPIPPHELRARERARRRKKLAKALERQARKLRAKGIAVDLEALKAEYLAQHKNSGLYSDSDGDGEGEDSMIDVVGGDSCHDSGPEDFSLTGRLRAPSGADGMNNSDSSTSDGHSGRHFSPTPDPQPSFFKHFGGASTNFEKFDFDSGRAVSLDLSGGGHATEDLSKNGGTRKHNPFSIESLLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQR2</accession>
    <name>A0A835GQR2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQR2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="333"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="715" mass="80705" checksum="E5D91F3329FC67B3" modified="2021-09-29" version="1">MGDYPDPDEEYELMYADELAMLREDEDHAEPSVVKKKPLPAKRSLDFSSPVAKKPVTTNLTNNVPDAITISGATESTDISLTPNLQPLEEFTQVSNKRTADELFGDIEDIDFNEVELPSKRQKTEEETDLELIEKILEGRRLRQILLEPSGRPLGSRSNYNVKDNMSLDIPRWPFVALSNSDGERIYIRIESEDDWESSLDKGMEQMSLHASYASTWDEARKILEDKQQKCISEEVASQPLPDMDTDLNGNMLWVDKYRPQSYLELLSDEPVNRALLHWLHLWDKIVFKKEVKTREPQQRTTFSKRAGQFQLTNKWKGKKEEEPELDEDGRPHHKVALLCGPPGVGKTTLAHLLAKIAGYRPVELNASDERSTEAFRNALQSATLMRSVLDAEKRPNCLILDEIDGAPLPTVELLVRWCTATATEGKKKAKQQPLKRPVIAICNDLYASSLRPLRLVSKYMSYDLKVLSFIKAKAKAQLSMQDVENVAIGTKDCNKNMMQALQSIFTTNDKEPDAILKTIQAAGEYDRLIDGIFENYLSARVDGRLLLASETLSWLQHYDVLSTWTLRHQNYSLYGALPLCIARCHSLLATRTPQRVKFPLQAQEMYRKKVEIESIVSSVLRGSEPSVSVGRLALVLDVLPLLPYLLAPKLRTANVQANRVPARTNATSTPAKKSNSDSAANDPSTSKDKEVPLPNHLQRLQPKVVKKNTPQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQU3</accession>
    <name>A0A835GQU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052865">
        <property type="entry name" value="Zinc_finger_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47241:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47241">
        <property type="entry name" value="FINGER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="396" mass="45320" checksum="39349D5764C3E32D" modified="2021-09-29" version="1">MGHLVTFLQLEAVIDKEEAKYAICLICKLKVSRGGEGKKAGTSCMKNHLKAKHPDKFSEIYGVGFNRLMQKAVPRYKLPSRTYMTEKIIPDIYDRIIKKIMEKILNAAAVSITSDIWTCDHNNESFLSFTAHWISPDFKLEHGQCIILLKPFEEITKITSSGLSCISEVIPHVAVLMRYIQKEETSRKVPNLLQFLTSLKTQLQQRFEHLDENLKYFLATLLDPRFKTNFFGIVSVKDRSKLVGKYVLNRNHMALRALDKLLVRPFWAEVAVAIPYCACPLSPNSGNESEIDLRIEIKIGMYQQKSQQINAVGTVQCDEAMLKRFKRFKPKDFTADRFQISTPADKLTGDTKKQNNMASRDVIHPRGVQLTPSAVDGAFIPCNYYVEINHFEYQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSB9</accession>
    <name>A0A835GSB9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thymosin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_009461</name>
        <name evidence="6" type="ORF">HW555_001724</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000510">
        <property type="protein sequence ID" value="KAH9636265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSB9"/>
    <dbReference type="OrthoDB" id="2151618at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9636265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23251" checksum="D9BC1DA4B941F314" modified="2021-09-29" version="1">MACSVDAPSLKDLPKVATDLKSQLEGFNQSCLRDVDTNEKIVLPSAEDVAQEKQHNALLQGVEQFQPSSLRKTETVEKIVLPNALDVATEKTQKSLFDGIEKFDATRLKHTETQEKNPLPDKDVVAAEKQHQNLLDGVEHFDKSQMKHTTTEEKNPLPPIEAIEAEKEKNKFLNGIENFDPTKLKHTETCEKNPLPTKDVIEQEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSI3</accession>
    <name>A0A835GSI3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57898" checksum="C0E6BAB98215A0C9" modified="2021-09-29" version="1">MADPEKKEKVEAQPLKEKEIIADINENESFISKLCRLKSSITVEPILAGLIIPSMLARLAIQNLNLDKTCRVKLNFNESICDALIDKRGNLTDYEGDIQKIISNIESWKSVIQTSIPTLLVIFMGAWSDRTGNRKVCILMPIFGEFMVCVSNLLSTFFFNEIGVEVTMFFEAIFPAVTGGWVMVYLGVFSYISDITDEESRTFRVGLVNLCMTAGVPIGTALSGILLKLLGYYGIFIISGLIYMMTFSYGFFYLKSNTKPRADKDEKVEPVTCNDMVTLIKETAEVAVKKRESNFRKKIILTLLVVGIVYGPNHGERIITYMYLRYKLKWDAIKYSLYSTYSIITHSLGALFSISVFSKRWGFHDSMLCLISIVSKLAGSIIMPFVQTDLHMFMIPLIEILNATTFTSLRSMASKLVPSEEMGKMNSLFSLVETLAALMFDPTYSKLYSNTITVFSGAVFVFSSVMTLPAICILVWFFVQHRKETAESRRNKRKDVETVYEAVPQQEKVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSX9</accession>
    <name>A0A835GSX9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSX9"/>
    <dbReference type="OrthoDB" id="7032324at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="9017" checksum="0F4FFA8493FE7726" modified="2021-09-29" version="1">MASIAPSDSESNVSGFIRYSDKDVKYLYTSIIQSMESINQDISVVETNLKNLVQQAGPLEGQLSALLQSLPKPNLNLPMEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTF7</accession>
    <name>A0A835GTF7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_000915</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTF7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF504">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="94"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9423857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="34220" checksum="B5E1B5A776FEA311" modified="2021-09-29" version="1" fragment="single">DGVTVSLTEARRSEVVCAGILILVCVVSPIIIVLVRNAVNTIQVYASNLAEKARELEYEKELSDSLLYQMLPPSIAKQLKQTQQVPAEFFSSVTVYFSDIVGFTAIAAVSTPYQVISFLNSVYKLFDEKIECYDVYKIETIGDSYMVASGLPVRNGNKHATEIASMALELLEATSMCRLPHRPDQTLCMRSGIHMGPCVAGIVGSKMPRYCLFGDTINTASRMESTGEPMKIQISDDVKKALDKTGLFLTAPRGVVDVKGKGEMSTHWLEGRIGPSPERPTTTSLDCTPSFLARIHSQRSPRYQSGKPRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTG0</accession>
    <name>A0A835GTG0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032774512" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="21184" checksum="7D2FB73D87570986" modified="2021-09-29" version="1">MIKRCLWIVFLWRVAYSNPQCSTTEVKSLLEGCDRLTGLNITSVGGTIVNDHNCDVLLPKQVFIEEPLFQYPLADAKKFYTLIMVDPDAPPQVDGEFYLQMVKSNIPGLALRTMDSSKTVGIDYRGYKPPAPPHGAGPHRYITLLYEQADGNNFLPTVPSTRHRFSLAKWLVGKNICGPVAGMEFKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU65</accession>
    <name>A0A835GU65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_000422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF457">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="526" mass="57764" checksum="EFE550C355F560A4" modified="2021-09-29" version="1">MNHGLTDSNLNFYVFRLDLHLILGPRISRLVDFSCCLHKSWNESAAGVLPARYILSVLGSIGFAIVYGLKVNLSVAMVGMLNHTALKEAQGVSDGHDSGGPAECTPSGGNSSVTELDGPLTWSSEVQGIVLSCYFWGYFISQLPAARIAELYSAKWVMFFSVFINVVCTLLTPVMCNLHYSGVVLMRIGEGIGGGVTFPAMHTMLSKWAPPSERSFMAALTYAGTSLGTVISMLMAGVLTANVGWESVFYVMGGLSLIWCVLWVVLVQDSPQQQRYMNADERTMILQALGNQEDQGHKQKHPMPWGAVFRSPAFLAILVAHTCSNFGWYMVLIELPFYMKQVLKFNMTENALAVSMPFLSLWFFSMILSRTLDWLRGKKFISTTTARKIATMFASLVPAVCLLAICYIGCNRSAAVALMTVAVTSIGGMFCGFLSNHIDISPNFAGTLMALTNTVATIPGIVVPIFVGYVTDGNQTISAWRKIFFTTIGLYAIELVTYTIFGSGEEQPWNKVETETEERETKPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KWT9</accession>
    <name>A0A835KWT9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000683">
        <property type="protein sequence ID" value="KAF9405785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KWT9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="27154" checksum="2D780098ACF19507" modified="2021-09-29" version="1">MQATLESNAKIPTIPISIKGETGYAYIDTAARTSIAGTQLYKKLIRHGTSFVERSADITLADGTIKTTTLLTAIVDVVIGERILPIAFSAIPEAKNNRTLLGIDFLESSGIVLNLPQRAWYFVDDPDKIFTILQLKNENIPLIATKSIDFNMETNTSLDVIQTTKLDNKNEEETLPDFIKWARELNMVSPMMETPSPVRDEDGSPGNKRPRGFFKNWTRHRAQYVQENQLMIILVLILALTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY08</accession>
    <name>A0A835KY08_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000441">
        <property type="protein sequence ID" value="KAF9407744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY08"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="77" mass="8716" checksum="A67AB4C06A6C7799" modified="2021-09-29" version="1">MSFQRTRPIDALHRIMTSFEHFEKKLDKLQDDVKTHGQTLSDLRNMVTVLSAGTLASADGKSDDYRRPGRKTTAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ05</accession>
    <name>A0A835KZ05_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">apyrase</fullName>
            <ecNumber evidence="3">3.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_013072</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000570">
        <property type="protein sequence ID" value="KAF9406615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1201">Platelet aggregation inhibiting toxin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033106948" description="apyrase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="14">
        <location>
            <begin position="329"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9406615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="539" mass="60109" checksum="5C8C22FC22BD0CD5" modified="2021-09-29" version="1">MQVVILLVVLACSAAANEDLYELNIIHYNDFHAHFDEISPSGGVCQPDVEPCIGGFARLYTAIQQARQVEPDSLLLNGGDTFQGTIWYNFLRWNVSQHFMNMLPHDAHVLGNHEFDHGVEGLVPYLEHLNAPMLGANVNTELEPTMTPYIKNHVIVERKNRKIGIIGVLLQQFSAPIGQVKMEDELEAINREAAILTEAGVDIIVVLSHVGYTSDMWLAERVSPTVDIIVGGHSHTLLYTGPTPNGDTALGEYPTVVQQANGHRIPIVQASCYTRYLGNIKFYINAQGKVERWHGEPVFLGSSIVKDERISELLEPWRVEVDAVGKEVLGESRVSLSRSRCSSEECNLGSWACDGFLEEMIPHAQGSNWNNAHVCLINTGGLRTHIIAGNVTTEALLMAMPFENYVQVYELEGKYLQEALEFSVGVNWSDSFSSGRMLQIGGMRNVIHASRPIGSRVSATVRCIDCDVPRYLPLDPNATYRVLSQNYIGDGGGGYTMISENRKNLQTWEIDYVMLQRYMRRQGVVTKDVDGRIQIDYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L051</accession>
    <name>A0A835L051_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_010111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UQCC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L051"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027858">
        <property type="entry name" value="BRAWNIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28492:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14990">
        <property type="entry name" value="DUF4516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="70" mass="7978" checksum="04718BB8BAB619D6" modified="2021-09-29" version="1">MPAGVTWGQYIAFSSAAMISMFAGSQIVHQYYKPLRDLNDYINRELKSLPDNVQEKIRKELQDEGVLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0N5</accession>
    <name>A0A835L0N5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_009526</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000214">
        <property type="protein sequence ID" value="KAF9411735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0N5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="18">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9411735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="25200" checksum="9AEDEC9D2047B46B" modified="2021-09-29" version="1">MTRENERLSQEEVTRLSDVRNLVNQLYEALNVREHQIRKERELKAQLEKLSTELQPLEEKRMSLEVETTRRTSALTWVGLGLMGVQFGVLARLTWWEYSWDIMEPVTYFVTYGTAMAAYAYFVLTKQEYVLPDVKDRQHLLTLHKKAKKIGLDINHYNSLKDEIAKVEKDLNRLRDPLHIHLPSSLGGKGGGADDKRSPLSKIKDMLEETSKKMKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0X3</accession>
    <name>A0A835L0X3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000308">
        <property type="protein sequence ID" value="KAF9409587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0X3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18507">
        <property type="entry name" value="BACK_GPRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF46">
        <property type="entry name" value="SERINE-ENRICHED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="438" mass="48658" checksum="8B992BB6DF7A9D05" modified="2021-09-29" version="1">MNAADYYGLDELRRACAGFVQCCITVDTVCALLASAERYIQYKCTKSLVQKVLEFVDEHGNEVLNLGSFTLLPQHVVRLILARDELRADEFTKFQAALMWSKKYCDTNQNMNLKEVIGNFLEYIQFHKIPANVLMREVHPLGLVPYSIIMNALAYQADPASVDPGKLSPARVRRAGRSMSVQSSLDPYGSNTTLSSTGSSDVPSRSPTPKTREPRSKSDSIKHAALTRQVSETVGASADPTFERCRPRKRDSETEFPVRKSTSELSESFPFVRRALAEIENGLNYFRRSIASDTSEPKPPFLRTEPVVVVAAAEEDEAPMSPPPPMGLKERRGSRGSPCANLPPLMLPPATPEPSPGHLTPNRLSPQRQKEPISAPVMRNLPPPRRTRTRSEMPPEPPPRSPQTPRPASVSPKHTFAFKIVLKKVESTPNTSFDKPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0Z4</accession>
    <name>A0A835L0Z4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000304">
        <property type="protein sequence ID" value="KAF9409660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0Z4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF9">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032389816" evidence="1">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="28294" checksum="5FD6A53A138AA1CC" modified="2021-09-29" version="1">MQSGLILFSVLSLGLIAATPVDITKFNQIQHNEDVAFRNSILENAILQALEGLRKDMVQGTNDIPVLDPLDVEHLELNEELLTLPGSHVTLKDLVVTKLSTFVVDTLSVTSETLLPLRYRITFDIRIPILVAEADNYDLRIIAQGLNIFGNGDAKVTLIEPKVHGHLILSPRLTIGSGLYYSITTSNVNFSLKGFDSNINGLMNDPGMSEFINTFLKHFVPDAVVVYHDDITKILSETVMEVGNELLKDLNLGSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L121</accession>
    <name>A0A835L121_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L121"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="229" mass="24191" checksum="5E4104CAFB4619BF" modified="2021-09-29" version="1">MTAVYIAGVVASVGVSILGVFCILSVLQLAMISSKERVAFKYTHLVMLKLALALLATLLSIVAAGLFAVQGDDRGFFVTRGEAFYVQIVSIVINSILFIMSLYDALFSRRAGGDPTNPLGEPEGTTINNPGFKEGRGISMTDASGKPYSTNGHGSVASMNTTATTLTGMSDASTITRSPLRSSLKKPRPREGEPGGLGIQNPGYSGHSPPLNRNGSQKKVRIQTHSTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L184</accession>
    <name>A0A835L184_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_010756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000281">
        <property type="protein sequence ID" value="KAF9410039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L184"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF65">
        <property type="entry name" value="BESTROPHIN 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9410039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="721" mass="81825" checksum="838D4ED4084AEDD4" modified="2021-09-29" version="1">MPWSETEETFYDALSYKVKHSKRVFFLVWRGSIYKLVWLDLLVFLLLYYVLNLTYRLLLNDDSKRVFEGVVNYCSFHGNVIPLSFVLGFYVTVVMNRWWSQYTTIPWPDSIAVFVSATIHGQDERGRLMRRTIVRYVCLCLTMVLTMISPRVKKRFPTLNNFVDAGLLLENEKTILDNLNDKFPKPSKHWLPIVWATSIVTRARKEGRIRDDFAVKTIIDELNKFRGQAGLLLSYDTISVPLVYTQVVTIAVYSYFITSALGSQWVDNKLQRNDSVNISNIDLYFPIFTTLEFFFYMGWLKVAESLINPFGEDDDDFEVNWLIDRDLQVSYMIVDEMHHEHPELIRDQYWDEVFPSELPYTIATENNREEHPEPSTARVAVPVRQRSMVLSAPSQVKIDEMNPSNTVSYKFDPPEQLQMNDDAVSGIHFIVNRGSKRGKKEDRNSMGSTNSMASLQQTPMARTNSVTSMLKRLFSKEEQRGAQTTQTDGGTLRLLRHDGSRFTISASNPTLNKPTTAGGGSMKIANDIIEEVDEQATITSMAKRPETRPTAMSLFTQAPPTPSDPVDVPVRNSNKTNSNSRLSSSAPNPYAVRPSEGGDLSPAAQSLNTQDSFSLPNERPRLDSDVGPSLSAAGSQTLLDEADGGEDPELDDFDRLRSIREQHRKEKYLQKLMARSISAQQRTGSTELMDNDLLLEDLLSQSAAAQKKEEKLKSDSKDNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1L2</accession>
    <name>A0A835L1L2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_008552</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1L2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000088">
        <property type="entry name" value="E3 ubiquitin-protein ligase synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="482"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9413110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="560" mass="63017" checksum="D39830FD7F61D3C7" modified="2021-09-29" version="1">MKALLATVISLGLTTVVIGNAYYQKKQFYPSIVYLTNSNPSMAVMYLQAFILVLLVGKLLRKIFFGQLRPAEFEHLIERSWYAITETCLAFTVFRDDFNPKFIALFTLLLFLKAFHWLAEDRVDYMERSPVIGLLFHVRILTLLMLLAHADFYFIHHAYQFTAVKGPSVQLVFGFEYSILIIMIVNILIKYVLHAIDSRWEAPWESKAAVLLYTELAINFLKVLLYIGFVAVMVRIYTLPLFAFRPMYETMRSFKKAYNDVVLSRRAIRNMNTLYPDATPAELAAADNECIICREEMHTGAKKLPCNHIFHAACLRLWFQRQQTCPTCRLNVLRAPAPEAAGAPGPAPPAPPLVGLPPHVAPAPPPPGPVPPPFPNMPPPPPMMAWGMPPPPPLRARRLLPTSPPRSCSAWRAMSAGTLKPGYKYSIQYLPCLSLQLLREIQAMLDASVLLMQQYSTVVANLPQNNVTVSTQTETRIEELIKESPISTTQGKSEPDVVPTTSSYKQPSPVPSTSKTIVTEDTSPMQPDTTTPVDTNRDKTDVDAADELRRRRLQKFALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1N1</accession>
    <name>A0A835L1N1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1N1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="47"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37787" checksum="DD89737CD120D0E5" modified="2021-09-29" version="1" fragment="single">CISRCRCSLVRMRRFAARQCFVNMTENGNMSIVDGRQVTNQVIDVDQLIHEIKKRPLLYTRAQTEYIQKVARQKEWADVCQALCKDFRQLSARKKRDKVRQVQSKWFRLKQSFLKGYGVTRPVSKIKKQRQIHKLSFLIPSTPVMEVDTGAGSTASDNNNEDELDLVMDTLANEKTEEINIPTASTSTENIATFAKENEVKKKPIFIPVPKIEEPKYDPIDENLHFALMLVPLLRGLNQDQRFYAWSNILNVVQKARELGPKKLSILQEELRYTDGEAPNLLQDLAYVQPEPEPPVDDEPIFPAAHGRPTNEAGEIMYPETDNEENDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L390</accession>
    <name>A0A835L390_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAM20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9412997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L390"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="218"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="440" mass="50358" checksum="AD1AFDBE1CDEB04C" modified="2021-09-29" version="1">MPNNGSNGSREYEQSAPGETSGGGTDAEPRTPAPPTDRYEDLQKIIFSQLQGKSEDHTVVIPPHRDLNILRPENPTIGEMEDLEPSINASNLERFQLKIAQHELYEDGEPLVDELLKDMATNSILHVEQKEGGTQLKLIIDYPNGVQALFKPMRFARDVQTLPNHFYFSDYERHNAEIAAFHLDRILGFRRAMPVVGRVLNMTTEIYDVTEGDILKTFFVSPANNFCFHGKCSYYCDTGHAICGNPDMLEGSFAAFLPSSDIAERKVWRHPWRRSYHKRRKAQWELQSDYCDTVRTTPPYDSGRRMLDIMDMSIFDFLSGNMDRHHYETFKMFGNETFTLHLDQGRAFGKAFHDELSILAPLLQCCLVRHTTLAILLKFHNGVPLSKVLRESLKLDPLNPILWEPHLLALDRRVLIILDAIRNCVNKAETPLQNEVNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3T4</accession>
    <name>A0A835L3T4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000150">
        <property type="protein sequence ID" value="KAF9413828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3T4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="33678" checksum="CC0A20EE8FD58848" modified="2021-09-29" version="1">MSIAGIFPPICDPIDGHLLLDGCYVNNVPADVMRSLGAKHILAIDVGSQDDTDLTNYGDDLSGWWLLWKRWNPFTTPVKVPNLPDIQSRLAYVSCNRQLEEVKKSDYCEYIRPPIDAYKTLQFGSFDEIREVGYRHGAAYFEGQRRGGGGGVSGAAAEGRQHDAQPSLTEYRYGTTYFEGQRRVCARRPSGIVDGKKNHPQPSITDYTFTDLAQMVCSVRTARDVENDSSSSSDYEEDQRHFEGYASEPSAGILEEGLRTRRVGGSLSLSEDEIDSEAEVYDPLNKRGGVGMLFLQDKDGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L504</accession>
    <name>A0A835L504_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_008649</name>
        <name evidence="16" type="ORF">HW555_011058</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 13"/>
    <dbReference type="EMBL" id="JACKWZ010000306">
        <property type="protein sequence ID" value="KAF9409629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000323">
        <property type="protein sequence ID" value="KAH9639591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L504"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="3 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="33"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="14">
        <location>
            <begin position="376"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9409629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9639591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="496" mass="52643" checksum="9ED66D7B56AF8528" modified="2021-09-29" version="1">MGYTFLRIASSAYRKGGPVINVTRNYATTHEADLVVIGSGPGGYVAAIKAAQLGMKTVSVEKDPTLGGTCLNVGCIPSKALLHNTHLYHQAKHDFANRGIETGPVNFNFNKMMEYKVNAVKALTGGIGMLFKKNKVQLVRGVGTIIDPKKVQVKGEKGIETINTKNILIATGSEVTPFPGVAFDEEQIITSTGALSLKAVPKKMLVIGAGVIGLELGSVYQRLGAEVTAIEFLGSIGGVGIDGEVAKTLHKILSKQGMNFKLNTKVTSVKKEGGSVKVEVEPSKGGTKETLTCDVVLISIGRRPYTTDLGLKNVGIALDDKGRVPVNNRFQTTVPGIYAIGDCIHGPMLAHKAEDEGIVCVEGIKGMPVHFNYDAIPSVIYTTPEVGWVGKSEEDLKKEGRAYKVGKFPYLANSRAKTNGEPDGFVKVLSDKTTDVILGTHIIGPGGGELINEAVLAQEYGAAAEDVARVCHAHPTCAEALREANLAAYCGKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L505</accession>
    <name>A0A835L505_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000140">
        <property type="protein sequence ID" value="KAF9414169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L505"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="119" mass="13903" checksum="CE15D4B9DC482D77" modified="2021-09-29" version="1">MSEFKMGDNIKVRYCNLKKKSQSESRPNYNTCKGRSCLTPFLCYERLKNPALNSRIGMEGSYTNASFCAQPDIQQRSNPLSFRIKNKKKSYQIPNLSYHRIKNPEWPIRPMSSNLDFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5J2</accession>
    <name>A0A835L5J2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5J2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="709" mass="79075" checksum="E937CD6A8B76097D" modified="2021-09-29" version="1" fragment="single">VQSADDLMMRLRGVGRAPASTHRFRAPVREPPRTAHTMIAHKHALAAALLCALAGQLGAGASLHCAMRREISPCTCRREDAGTGAILVVCQRISAYEEIARALTNKFSPETKIGLDISYSQLPDFSEHSIKELGLSITRLKLNFDNLRQVDYELKESVFTKLDLVDYFSLADNSLTEMPRHVLQHLPHVKTLDLCRNKITKLTEDDFRDIQEVEHLLVADNQISKIERDAVPKALKHVHLGINKLSSLNGALRDLDDLEWIFINANNLKSIDNELPVKAKRIVLIHAAHNELQTLPKDLKQMPSLESLYFYGNNIKLLDGALQKSRRLMRIGLSFNKIESLAEDEFTEAEKLAELDIAYNQLKSLNGSLKSLKSLRYLNLTHNYMTEFSLQEIKGLKRLSVIDLSHNRISLITGNMENLVDVETRVLELRLDHNHILSLGGALMGLHGLLRLNLSNNLLQQISPDDLIGLEDLRLLDVSHNHITTLEETSKTFLPSLEELIAHHNNITLLDKDFHGLPSLCIADLSFNHIKTVNYDVVSKSRCTINGVPSVLKIYLQDNPVLCDDHLYELITVLETLSARINGASTCEAPQTTAPVPLRAVNDVVPPQETPPVIVMTQMGGGPRALPDGVDHGAASVPQVPQLMYRRVGALFGHVLPEREGGLPVVVEPPVTLPPASTNVVVKWPDERRMEETHPLVDHLRLRDLNASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L603</accession>
    <name>A0A835L603_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RETREG1-3/ARL6IP-like N-terminal reticulon-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L603"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="6">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="37011" checksum="9A0C1702C98881AA" modified="2021-09-29" version="1">MLASLKALKWNTAKTLENKNTQTSLLLAAFLGLLEDVLFWKKMWMSLLFIFLVNIVFFVSVYQQVNLLEFILISWTAVVIIDAFESWLKHKHRTGCLKRFSEHGDQISSVAFQFKVWLKNRCNEFLYLRETNHTKAFLLINIILIIFFLTGKYISGYILVYILLMSICLFNKVILPIIKLCKNMRQDFESDFELEGLIPEASEVDIKLLSIEPDPVPVMDERQIYDYWKPEDVPLAECSDSSDNSSSLVTNFSMEKMQTLDKDVDSSDTNQLKGKTKDEIYIRGSGTSQYMELYCLQHILEYYWSCGKYDTIRIQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L646</accession>
    <name>A0A835L646_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_004807</name>
        <name evidence="6" type="ORF">HW555_003631</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000837">
        <property type="protein sequence ID" value="KAH9630101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L646"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="5">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9630101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="645" mass="74899" checksum="AC51795BE93FC940" modified="2021-09-29" version="1">MPQTGATRRQKFLKSEKSKTKLKGKNKELPKGTNVTKTNFKVKKIVLREQLKKHGESEALSTRKLNIKELLSRLNHFNTHSRTEALNGIKELIEFHPEVLETSLGELVHGVTPLVLNIEKVVRHESLKTLHVILSKANIERIDPFFDIMCTYLRSAMTHIDGRIQEDSLLFLDTLLLCTPAKVAQDFHKIIPNFLDMISKLRVDSKPGRTLTVNLGSQITSVKWRVKVLHRLKDYLHEFVKYNNIQDYNGPVVDTTKIFDTTKMNHYSLFNSSYVQKCSLSCFSSKNLQETVPLDEVEKFREYTDTLMPLLFETWLEVCPNISSEKNIETVVSEDAAALLNHTLDVISLIWSLVKHFNTKSPSSNIQHTFSQKYRQQYLQHFVNAFPYVTNIRIKQRSVTSSEFENTITDPKLVAQNLLICQLFILLNPNINVKNQNKDVLSILKYIEKTFHKNTQAEINDIIIKILHTIFSNEVNNWTRTISVMNDLFQKIVWAYFNKELSSSFRQKIFSLLCKIALNDKLGHFHDCDAYNTWLKNLPDILLEKTVAVQTVDIIHKFAVRNNQTFNMVIRPKLLEIVQNLPSIIITDVDSNQSSYYKLFSLLYYVKKWDDETLNLLRDQIINSVYKSDYNNYIFETLKLKSGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6B1</accession>
    <name>A0A835L6B1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6B1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="547" mass="61237" checksum="D7CB37D359091BF4" modified="2021-09-29" version="1">MLPRWRKNIARLFLIPQRYVLGIMGLLAVCNAYTMRVCLNLAVTQMVNNTKGDEEQHFDPNACPDDSEYFTNGTVSSRPYAIFDWSESTQGLILSGFYYGYAITHVPGGYLAERYGGKWTLGIGLLSTAIFTLLTPVVVKAGGATWLFILRVLQGMGEGPTMPALMIVLARWVPPHERSRQGALVFGGAQIGNIFGSFMSGFLMAGDGDWSNVFYFFGCFGILWFLAWSILCYSTPNTHPYISEEELKYLNETVTSADTQSVRDPVPWKAIVRSVPVWALLFAAVGHDWGYYTMVTDLPKYMTDVLKFNIAATGTLTAIPYLAMWISSFIFGWVCDVCVKRNWHTIKTGRIIHTTIAATGPAICIILASYAGCDRFAAVAYFIASMALMGGFYSGMKVNALDLAPNYAGSLTAMINGTSTISGIITPYLIGLLTPDSTLAQWRIAFWVCFAVLVGTNVVYIIWADGKQQWWDDVRQYGYPEDWKHGQLKMANQDKEKNKQIEAKNSSKIYYYINKIKYFNTELFLIIIKNVPSASCPNNTEREIYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6K8</accession>
    <name>A0A835L6K8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Timeless C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6K8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF5">
        <property type="entry name" value="PROTEIN TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless C-terminal" evidence="3">
        <location>
            <begin position="769"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129397" checksum="A90006D987EE496B" modified="2021-09-29" version="1">MEWVLRSPQIHSTFSNLGFLHADGYHVNENCNAALETILHNILTEDKYLRTYRRSISFGQNIKKDLIPLLIHAKEDATIELLIRILNKWAVTMVQLIALLYKDQHVVTLHKLLNLWIEASLSESSEDNESNTSPPDRGSDSSPMCTSEPTSDSSDTGGSGKSNDDPNSVNKDWDASSQMNNTSENGNPPFQTTEEKESDNEDKNNSIESNNDEIVQSDNGQSSSCSGGAQSSRNGQGQQPGNTEKKTVISENSDCGYGTQIENQESISTSSNEDELPSKKPVHQKPHNPKQRVNNKARSGVTMQDRKRKKIVKRGKSNIINVQGLSHKTPTDDDISNVLKEFTVDFLLKGYNSLVQTLHNQILSNLQLEIDTSHFFWLVTYFLKFATQIELDLENVSSVLSIDIVSYLTAEGVNLCEQFELAIKLDGNDLKPNIRRLHLVVTAIREIIQAIDVYKKFSHICKEDQEALLKLQLKMCETEELRSLLVLLLRHYNPKYHSKQYLQDVIVTNHILLMFLDSAMKLPEYNGSTNMLDHIRQFASSEIMYQYGLLLEDYAGNGEFVNDCIFTLMHHVGGELESLITLFQPKILKTFTSIWKSEFEICDDWSDLIEYVINTFIKKPHSLQSSANFRLDIENFDDVKIIPKPTVALPAQSKSETVEAEEKKPTTKSNTSCISNGKGESRWTEDELSSLSWNYMQCSALPDVVGEIITLYKEDGIIKSRDSVIKELYTQNLINKEDYDKFVKGENDRNIKTVQVMKEMRDDEINKLCEQLTQDGKSKFLDWVQKVLLETCFAKIYLDKLARKSEGDNTIEENETKLSKLKKSNDLHILSPVSYHSLLMNQSIPLVPWNCKQASICKDLKFLQLLHKLGFHMPVDSGKVFIRIPHFWTADFLYDVAGKISPIDKSKLKFSINDISDSSISNSMQQENLLLLPDLTKDISMIENSDNFYQIHKQKHLATMVNFTPMPSSSFNSEGGDVDKHNWLEVVQKSQEYKIALNLGSSIIKSDEEAQSDIVNLQQLPVKDTEVSVPPLLLATGPVAIGSTATVTGASFPASGLMMPTIMSIKQETTHFNLPVPDSEHYSVCETASVASDLTRMYVSDEDEKPEVVRPIIAVNPIHDESDELCGDLDDDNSGKRPRVNYFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8C5</accession>
    <name>A0A835L8C5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L33, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8C5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.120:FF:000005">
        <property type="entry name" value="39S ribosomal protein L33, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="67" mass="7965" checksum="82158D5FC0E946E8" modified="2021-09-29" version="1">MFLTNILCKKAKSKLIMVLMESVVSGHQTTMIRERLADKLEFIRFDPYIQQESLYKERKKIRSIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8H6</accession>
    <name>A0A835L8H6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8H6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="245"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="647" mass="71079" checksum="2EF15663F7A91A92" modified="2021-09-29" version="1">MSSSKENNTNNEAHESLLYSARHGELSVVKAMLEAKDEGKLTIDINCKGKNKTNLGWTPLHLATYFGHKDVVEALLEAGANVDEVNDTGDSALHKASFIGNEELVILLLKYKADVNIMNGEGRTPCDMSKTRDVQRLLEAAGRAERHERELRLLTAAKDGRIEDIQELLSSPNPPNINCVDAQGNTCLHCAAYRGHTRLAVLLLQNGVDTTLRNNSGQLAIDMAKDTEMREVLSVRPVQRLQRTAARFEGPLMKRSRFLGWRPVWAVVQRGVLLYYGSRAEAARGGTQWRGRKYLDGATLSASDTDPAAILLRFSDGDTHRLAVQAERDVPACRQQWITALNEHIAYSGHYLWAGASPDTAREATEDLEDECKPLGSMQDALTAATNSLALLDTQLRECAAIVAALDKSLNVGTSLHHSAYMRFQHVCGTGSEALSALRHCAALVAQARDADSARLSREIERNRVLEEALAALARTHHALEMSVAEELTKSKRKKKSKSSSTLNDSKENFFDVFEESEDEDDTLVTAGLSSPLGALSPWGSSPDLTRRTPIGSLDGDKTPTNEEQEERYLRRLSGSSGSPVSLHTAVSAASSRGTLVSQGGHVYRNARPYRKNTHPRGGTLPYIHQDRKDRGAILHLLLRNTQCLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8P9</accession>
    <name>A0A835L8P9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000132">
        <property type="protein sequence ID" value="KAF9414492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23590">
        <property type="entry name" value="TFP_LU_ECD_Bou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF18">
        <property type="entry name" value="BOUDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032407293" description="Protein sleepless" evidence="10">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21060" checksum="1FA1B97FAD67B42B" modified="2021-09-29" version="1">MPSLQEKIFLCLCISFATFKTVYSINCYQCSGTDSNNPFQCNEFLENDVDLQPTDCATIHNAQYCIKHVGRFEGLAIECYQCNSSSTMECGDGLMNLDGGILKPMPCDHVYNALYCIKLTGGISTKRFCSSLDLGNYCNYVQQPGDKLEYRTCIFTCSSDGCNSATSLHFSVFPLILLFVVTYFINRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8R4</accession>
    <name>A0A835L8R4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8R4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="360"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="526" mass="57608" checksum="0903A34BFA505D88" modified="2021-09-29" version="1">MHWYGGSIAEAVTLSKQKNAIFVVFVEGDNDLSVEMAATIDDTDVLNRLSDQSNFLAIKLKSGSPNYNYFAQIYQFVPVPSLFFIGRNGMPLEVVCAGVQPSNLAVRIDRILEQHFKDKQPSPTGAQPAAQEPVQPPTSSTNIHGSTDVKDQTVNFVQAETAALVSQTAEAPKQVNDDLASGSPPPKIPKTAQETKPLTPDDMECDGDVCVRRAPKADEPGPSQAPTPSLSSPPASAQAPEVATTESLGSIEEKMERAKELIEARRREKADKEKELEKEKEMERRAQGKGVAELKRWQADQELKQIQEERRREKMENNLARQRILEQIAQDRRERRARDAPPPAPTPATVPPQTTPTSGDAGRGARIQFKLPDGTSHTAHFDADGTLGDLSTSSFALWTAFPRRELTDAEASLRGLQLAPSAALLVLPRRTTPTVARPSAVASIITFFTQLFTTMILEPSQTLLVWLRTRLFPPPATSPRTPRAPSPAPPAPPGGVRRRGNIHRLPSDRAPDDDNNTWNGNSTQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9T9</accession>
    <name>A0A835L9T9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9T9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032837776" evidence="5">
        <location>
            <begin position="23"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="228"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="536"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="621" mass="70621" checksum="4B47845424A498E6" modified="2021-09-29" version="1">MKAILLLAGVTLALCAVPPVDQRRPHVHMNDDGSYFLTNDGPSGPHYVGHIGRGAVQGKDNGVKFDLQASGETWRGGLKISITWTGPADVVFQDCIDFGNSQWFAGPEQKQQYWPIQNSLLKKYSAVSKEEDNAAVGERYWLNSDGMYIYVAPEVPLFIDYHNELENHLCLIAEVADPYSTRRTENVLKYDLWFFENPKIAHQHAVDNYLGKPSGIPDYRMIQYPIWSTWARYSREIDQENLWAFANEIKDSGFPNAQFEIDDLWEVCYGSLFVDVRKLPDLKQLVQDIKGLGFRVAIWVHPFINKDCEPWYSEALGKGYLVLNEEGSPDTTWWNNNGSIPGYIDFTNPEAADWFSDRVRNVIETYDIDTVKFDAGESSWSPQIPVQNGLDINLHPGHIVQAYVRTVAKFGPAIEVRSGMRTQDLPVFIRMVDKDTLWDYNNGLETLITTLLSMNLNGYTLVLPDMIGGNGYNEKPSKELFIRWLQANVFMPTLQYSFVPWDHDEEAVEISRRYTDLHAEFADVIVAAMEKSVSDGTPVNPPIWWLDPHDEEAFPIADEFLLGEQILAAPVVKQGAVSRDIYLPRGTWRDGNTGDVIHGPIWLRDYPAPLDTLPYFILLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAR4</accession>
    <name>A0A835LAR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_001833</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAR4"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001026">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01223">
        <property type="entry name" value="Pmev_kin_anim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9422435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="261" mass="29862" checksum="5D2387E6618B076C" modified="2021-09-29" version="1">MSKEQNIAGVECSGWLRALGAVETSWLSTTVDSGQTYTHSATQCRGGGAVTMQFAPRPPPTFTNLRPCSWESWYTVMPQIILLFSGKRKSGKDFLTTHLQNLLADKCEVLKISHPIKSHWAKEKNLNLNELLGDSEYKEQYRLDMINWSEEMRAQDYGYFCRIACQDATDKPIWIVSDIRRKTDIKWFKEKYGDQTRTIRIIADEETRKKRGFIFKSGVDDVASECDLDDFVEWDLVLDNSEGKQKLEEQLSSILGLVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB20</accession>
    <name>A0A835LB20_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029445">
        <property type="entry name" value="INTS5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14837">
        <property type="entry name" value="INTS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="193"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="618"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="98120" checksum="EA49A885EF59BE74" modified="2021-09-29" version="1">MNPQSKSTALSVDLNNFIYGVSRRNTQNAPELTRTGLSLLKNFPAARDAVLEYFAMVFHDAVNVSITQTDYETDLGANGSLESVSIIGPELCSLGQSWAPFIAPWCISLIMDIATKKSSVPNTTLQNADPVRILLDITTQNLTLLNSEERAKCIDMMLGSWACSWAVGWVGRAEPALVAPRALQLGADAARAVLAHLANHPPATHHVRVAVLDLFHEALRDDSKPEKKRDVIPYLLNLASKSDIVLKALTQDIEQTLTDEVMERLCGVCVSQRGSAAWAEVSPAALVALLLRADVRCLLLLLRHALSNLFCRQLLEYLLQKLEYECLFPDKNIPLLMSAAEEINIVRDKLLDGNQLEKYSLARILILVSYNLPSEFVSTISYLLQYSRDDSTLALLVRIISGTITMHVPSDSPDISMDTERYQNFVKTGVEYALRDAMLSDNEIKMCFLDGSVPKDQKTYLHHFCLNIIKLLRWENSNRVPHLRTRPIGRAVEANLYRIGGALQEYTSLLRIRKECTMASLDEMPTCHALAEVLDRVDMTGTKAPPPSVEVILKVVQATVKYFFRCLHLKELMEKLRGVATACRLLRKVCGCSKVGRAAALRDLLEHAMLRHDAGPITQLTQSHTSVFHAGIIGKGVRKPNGSDSNEIPPILTTNNELLMGALTACMVSDGNSGLVEGATSVSLLLVELVSPDVMYNGLPWPDEDFTKQVSIERELYMRGALESCAVARAALRRAAAARPALCLASALLRATAATLLHRLRAYLDRHTQSAEMAKERAALTELLSTMTLGQLLPHPLSHMLELAPELTASEIVQVLRDCLWNYTRDHVPSPALFTCDSTGLHWRDPSTCKPPATYTDTLRLIIQKRISKLGHLYPIMFLNLEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBF0</accession>
    <name>A0A835LBF0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBF0"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000016">
        <property type="entry name" value="ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF71">
        <property type="entry name" value="FI05338P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="396" mass="45741" checksum="39992D581EAA9CA5" modified="2021-09-29" version="1">MFNYKYLSREHLEGFDNYKYMAIDTSPLSVYVMHPFWNKVVEFVPKWVAPNVLTFGGFLLIVLNFMLLSYYDYDYYAASTPLYNETVTESPLNGHVEVIPQSLWYFIGIFLFLAYTLDGIDGKQARRTQTSGPLGELFDHGLDSYTVFFIPACLYSIFGRLDYSIPPIRIYYVMWNLLLNFYISHWEKYNTGVLFLPWGYDFSMWASTAFFLWTGVKGTGFYKKYVFGGYTLANVFEVLIYGTGVVTNLPVALYNIYKSYKLRTGKMRSPTEALRPLWSFASMLLVCSVWVHKSSRLPEYDLRALFLLIGTLFSNVACRLIVSQMSNQRSERTNVLVYPLCAAAGLSLLQPQYEPAAFYAVTALTVLAHIHYGACVVRQMCDHFRINCFYIKQRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2V1</accession>
    <name>A0A835G2V1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000509">
        <property type="protein sequence ID" value="KAF9407079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-rubredoxin oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="387"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="472" mass="52804" checksum="EB9834C50DA90E2B" modified="2021-09-29" version="1">MPVIEVTYLVVGGGIAGVTCVETLAILHPEETLAIITASSLVKNVSNVSFFAKTIVKFDVNETEASSLMRIHPNLKIIFDSLKHVDTHNQIAYTYAGDEIKYKVMCICTGGVPKLIRDSDKSKRILGIRDTESVKEFQEKLRMGRRMVVVGNGGIASEIVHATSGIQKVWVIRDDYISATFIDPGAAEFFQNTFKNRESQPNQKTVIRRHVFTEEDQVVSLNKDLKSAALGPDWYRKLEGIKDDKGVQELEIVYKVEISSVEEKSDKEFPLEVVLSNGRTIECDFVVSATGVEPAVNFSLDEEPVKGPEGGLAVNEFQETSIRNIFAAGDVAHAAWEHAPHWFQLRLWTQARQMGGMAAKAMHGRVVNEEVLQDFCFELFTHCTTLFGYQVILLGKYNAQGLGNDYEILLRMTPNHEYIKLVLQNGKLQGAILIGETDLEEMCENLILDQLDLTPLVDDILNPDIDIDDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G422</accession>
    <name>A0A835G422_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000654">
        <property type="protein sequence ID" value="KAF9405997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G422"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="12">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9405997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="282" mass="30640" checksum="1EFAAA64879B0D29" modified="2021-09-29" version="1">MVNFTARGLMPPVFTPLNDDHTINYGVIPAYAKFLADSGIKSVLVGGTTGEHMSLSVADRKKVVDAWVVAAKTTGLHIQVQVGGAPLADVIELARFCQDVGADSLLTLPELYFKPSTVDDLVFYVSQVAKAAPKLPVLYYHIPSMSKVEINMPAFVTAATASIPNFKGIKFTSNDLSEGAQVLRALKDGQEMFLGADTDTRTKHRRTSWHQTVTFSHVDVIQCLTAFTIQSSFICPWVPIMKAGMEIVTGIKVGPPSLPQKPLSSEAKQRIHSKLRTLGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4A2</accession>
    <name>A0A835G4A2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000744">
        <property type="protein sequence ID" value="KAF9405422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4A2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032310413" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9405422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14400" checksum="94D25DFC36DAEBA3" modified="2021-09-29" version="1">MLRVLSITLLTIAVEQVFAQDTSKEHRGLQACGGQLKGPVGTITTPNFPNPFPVPIKCKWIIEHDIVNGTISIYFTQQYTTSGLTFTEYMYYDESYKLGERRALTLTDENITRIKLLQGFSLHGPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4K5</accession>
    <name>A0A835G4K5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000583">
        <property type="protein sequence ID" value="KAF9406496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4K5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="5">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9406496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="998" mass="107687" checksum="94975005F13B2EC9" modified="2021-09-29" version="1" fragment="single">KLVVNQRPEVWEGSEFILTCMAYGSPNMAFTWYKDSVKINFNGTTRDIWTRTVSEDALGRRMSVLGVTEAERLDSGKWSCAADDAGRRRCRALRLTVLRPPEIRLVPSTLTVNRGDNVTITCLAGAGRVHGALGFSWARERTLLPMAPGREVWEDLFPAGSVLKLYNVQKSSEFRCQVSSVAGTNAKAVTMWALGSGDAACESDASHGLRWPKTAPGAHATASCPPGHSGETTRFCEPKTGEHGVKWRLPDFSGCVADSLRDIYEQVFTLISMGYSWGSVSHVSRQYGAVLRSLPTHPGEGEPPLTHAKIFDLQNAVVDTAGLRSSFNKRYHEFTVMSKPVLEDNAAHFDLQLALAEREEWAVTSAGVELVTKTENASVVTALYHDLGARLPSLKRFVEYKSGRATQYTIASQQIQLSVSGAGVDNTLLHTVTLLFTHSKNYSTIGPQLACGSRSRSSPRVWSTHTCELRVQEQTYIACRCRGLATITLFTVDSLGLTDAESDSRAIVKITVSLGSAMCLVAALLQLLSLVVGSKTRLPVLLRAATAATHSAAMLALLECDTKQTSACVGPLGWAVAACWCAGCAALCAQPLLLHTELAATATRAPSVGLLEGVSTLCWLTARLWGGAPLQLGAAANAVCGAGAALLAALTLCLALCAARTLRTVTQKLPPDRREYVRERVRVVRHTLVLLFTTTATQIAGVAYAQPGEKTIPKVVALSVAALANGLAMLICYVICDEECLRAARRLLTLSSNNEWHDSPEGDTSLSLYIRQGREMECRGAVGSLECSSSHVSPANTYWRATPLQSPLHRRGSSGACVADIVRCVEYKQALLPPRNVHTRTLCDLIPIGGAEPRVSRVCVELGVLPEASQTTVTDASTFQPPSDTSDISKANCTLCAKSTPDVSATSTAPRPIKSCLKKRSPQLSWSTSLPSINHESDESNSHLQLVDTQSQTPSTHTTFTQTDKVLHKISHDLDFLLNRTPSRVADNCPQQIEEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6A4</accession>
    <name>A0A835G6A4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6A4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="154"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="564" mass="61003" checksum="E3D93C9EFF4FB092" modified="2021-09-29" version="1">MCVGKTARSEMTFIKLTARNVTSNTLRSILSLLFMLKNKAQSSHMKFIGRFLCERSGVSLSESPGEFGSVEALGVAGAIPKSRSDKEPDDPDLSRQSGDKLYEDESGVPIVLDVPDFKEFGRKFCIVLLMPLHYCIRCISNFQAQQKSKIKQRDSGYAQTNFMMTPLSENNVNTRGETLYQESQIKTRNVVERAFGIWKRRFPILSRGISIHLHRVPGIIVATAVLHNLAILRKENIPPEDQDFPVIMEVRDDDVASERYGRGRANLQRRLLIEGYFASFGLSLSEGGGPPPKNNKFNLFTVVSLENGLPDINLAMEKFGFTYLWNRGLRISVRLSSLSNKSTDGISSESKGTDGAVDAEDLEQADSLGTADTENLEWAGALGTADLNRDSGYRGFRADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLELADTLGAADTEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6C8</accession>
    <name>A0A835G6C8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000419">
        <property type="protein sequence ID" value="KAF9407958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6C8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="559" mass="65482" checksum="33211926E1A2328A" modified="2021-09-29" version="1">MSSETSEQDQHENDMLSMFASVWVKVEVGETEDNLPFVDPDQEVAVTVQKKKKKPPRPTETLKCQFCDYTTVYKNCLKLHIMGHSNIKPYSCDACNYTTKYPTSLHRHMLIQHNFKVTDHLQMQVYQCEICPYSSYFKWNLKAHTRKHTAEKKYKCEQCDYATAYRHNFNKHHKVHNKEEMMYKCDKCPFVTKYEGHIARHLAKIHNEVSDKARKCDMCDFSTKVQWRLNVHKRRSKQNGVLKCSFCDFETSFMCESKKHKAMHFDDAQEVKLNESSGEITVGSGVVPIPQPDESSVHEKFNNYTLDPNCEIDWHNIKVLDSNSKDRPFQCTMCSYTSRFKASVQRHFQRHHTGSLHRPYKCVNCDFSTKTKDQIALHNKRSQSDAELKCTECNYITYFKCQFATHQKCHYAHKCPDCGYTCKHKYEFQRHMSMAHMGNTLQCRFCDYKAVRKESLLCHETIHTGNKPFKCKFCEYKSVRKSLLDNHLRKRHSDVLGERVVVKDSKIASLKVPIKSKDLVEGLKDRNVTMEELIDEQNKKDYASGGQTLRRRVPQPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G782</accession>
    <name>A0A835G782_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G782"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="25042" checksum="B0F76D22697EEA96" modified="2021-09-29" version="1">MEFGDQNFINVSQIKSDEHNERANFNSETDDPLQELGVDLNLPRFYKLDDIVFAEPLPNISNDENALKDTEQHNHITVVDNVIIKKDPGKKYKKYVMDIDASQLQCPQPNCIRFFATTKLLKTHIRKVHCADKQKYICDQCGRGFSARYLLQRHVLVHSGDSVECPVCGAKLKRRTGLTNHLRSHQNIRAHECGVCKKKFTRASTCATHVKFVHKNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G796</accession>
    <name>A0A835G796_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G796"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052830">
        <property type="entry name" value="RCC1_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46849:SF1">
        <property type="entry name" value="RCC1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41321" checksum="64B77A14FF9D3A36" modified="2021-09-29" version="1">MELYVTGSNIFRQWHCDDLVINEFRVLSPSKHIVANDRSRTNLLEINWSYNIVQIDDILYISGAWDGKENQFTKVPLPSECVTSKVDLCVTGNDYKIILVDKKMAALWALDLNKNEVKKLNFFIEKAIEDNMKKKKLDDSVTKAVLSSGTCLYLTQRGHVYSGILPSYVDTKHCVGKVIDVQCGHEHFVLLTEEGRVYTWGNGRRLQLGHGDISSLEVPTEVEALAGIKILKISAGGWHNLALSEFGDVYAWGLNDTGQLGIKHLNREHNESFCVPNLVSLFDKQGIEITRNVKDIACGSKHSALILDDNTVWTSGCNKYGQLGLSEQKYPSLNYYKNVFQCDNEDRNCSLICGPWNTVIFCKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8N0</accession>
    <name>A0A835G8N0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_006022</name>
        <name evidence="18" type="ORF">HW555_009524</name>
        <name evidence="17" type="ORF">HW555_011393</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000332">
        <property type="protein sequence ID" value="KAF9409176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000213">
        <property type="protein sequence ID" value="KAF9411778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000083">
        <property type="protein sequence ID" value="KAH9644489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8N0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="557"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="927"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9409176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9411778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9644489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="972" mass="107974" checksum="5312E727A9E13579" modified="2021-09-29" version="1">MPATRRLLTARWFARRRQPDEDDARPRTLPRSEMDRRPRVSRVLSSPARTQHQTHPPIDEESLERAYPSMGHLEYVNAGSSPPAESAPNMYDSFEEPPLDLTAHICGDSLRQSAHEQMRAVGGRLRLLDELETGVITADSAATTFSTATEAEKNVCLFWAAFLKLANLLQPLIEVGADPLYFDALGLSPLHVAAFSGSTECANYLLSCGSDPNYMPRCFAPLHCAAFGNSVQVANLLISRGASVHCAVKYVNCEGGLLHCAVRANSVECLKLFISHGVDVNQIEPGGTNAIHLAADLGMFQCLTILLETPGADPNVRTRVGDRESTALHLAADGGFVDCVDLLLSKGADASLKNHRGFTALHLAARSSSLECVESLLRKGNAEPNANDFDMRTPLHAAIGKSDSACDIIETLISWGANVNQKDEYGFTPLHLAALDGLSACVETLIYHGADVTTRSKKGNSALNVIARKTPASLAMVTRKLDCAITLRHSQTSNREVELELDFRSILHHCYPREISYLNTFVDEGQKEVLLHPLCSAFLYIKWEKIRKYYVARLFLSFIFVLCLTLYVLTALAHNCYNGSKDMEETIQEQELCQKQSILGDLLRKNPFVIEMQWWVLAGITIFEIFRKVYGIAGYSTVKQYLMQSENIIEWFVIVSVFLISYIYTNITYTWQNHVGAFAVLAGWTNLMMMIGQLPVFGTYVAMYQKVQKEFAKLLMAYSCILIGFTISFCVIFPDSSSFANPFMGFITVLTMMIGELNLDLLLNEPDGNDPPVLLEFSAQITYVLFLMFVTVVLMNLLVGIAVHDIQGLRKTAGLSKLVRQTKLISYMELALFNGYLPKCLLKILHSSALVSPQAYRVVLSVKPLNPSEKRLPRDIMMAAYDIAKMRKQYGHTISSSGSTTGAYSCFKKYENNNDSGYREYGYSSGLGSLQARLDETSENVRQLTQEVRELKKLINAQQLVLQQALSGAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8P3</accession>
    <name>A0A835G8P3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_010623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000272">
        <property type="protein sequence ID" value="KAF9410229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8P3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20905">
        <property type="entry name" value="EHMT_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047762">
        <property type="entry name" value="EHMT_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21533">
        <property type="entry name" value="EHMT1-2_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="746"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="877"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9410229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112909" checksum="63AB87062498ADB7" modified="2021-09-29" version="1">MNTDEETPIKKKVDKQPTDNLTVTLDKIDAKRSEKGDEEPKPRIVLTFRSEKNSAKSSNMKIVTNEEKQEEAPRRSSRTRGKWEWVCDSDTSPKKNKSGTQTTSENDESDSSHTTPKRSTRRRSKDSDNVLANAIARKEKSYETQQAPQRLSRRIKPTAKILANEELRMGLESQNNARLGINEKSPEEGVRTRRSVRPLAMEIEKKKEPEMEVEEEMAVLGEDDDSQSQNTVMKLKHLCELGLKAISPDEAEESGNENSKLMEADDSSDADFRCSVEVASKNRPRRSTRLCSSVGFNDSDRSSPVGEDEHKSPRRSSKRSRHNYVDDSERTHRKRRRHRSSGGDEPHSEVEVEDISNPAAADEGSEAACPTDETTIIAACFCETPSNVYAAPEELTEPIFCQAIELVDGVRVGCSHSARRHRSLVSSGNPSGLAALVRAGPRAPYFLACNLHAAQLAKHMCCPACGLFCTQGTFYQCSSGHLFHLDCGLPYNDTKQVPPGCPHCGMSSYRWKTVNDNCVKVKVEMKCSNKRIFLPDQREQCTPAYLSFAVREPKPETSPIIPEDLLPSPPIDLKQLCQQAAQAPNKSPQQLCDAILRGETVDQLLPKIDLDHLDHHMRTPLMIAILALVEKPNKKKKGNKRSKSEEPERDDDKVEESEKQDKGEEKADEEDEDVRAKEEELIKVIRYLVAAGCDVNLPGPDGMTCLHLAAQHGLIGVLPILLARADVDARDHGGWTPLVWAAENNHSQVVKHIAARQGHYACVVILLARGARTDIENAAGELPVEVCTAQCQSAISLNMQMTIAVKDNLPRFKLLSSDISNGREPFPIPCVNEVDDAPLPNDFTYVTQLVMPVPIDIDNTIGTLQGCQCAEGECGGPSCSCVALGVRGWYSGGRLLPSFPYHDPPMLFECNQTCRCNMQCSDKTQLCVDAAQYGSAARFINHSCRPNLAPVRVFTDTRDLRLPTVALFAITDIQQDEELTFDYGDKFWSVKSKWMKCECGSVDCRYPTISEDTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8U8</accession>
    <name>A0A835G8U8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011270</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Vatanparast M."/>
                <person name="Kim Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000324">
        <property type="protein sequence ID" value="KAF9409326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MT375604">
        <property type="protein sequence ID" value="QWM97829.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="82"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QWM97829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="342" mass="40236" checksum="C16C6617F5039077" modified="2021-09-29" version="1">MSVFLWLQRVVYYNLLTVYYNVLMLIGFLVVYLKNPFASPWTQKLKLEPPARLTDPKYGVHKYIKVNGTVLHYVESGDPSKPLMIFVHGFPEFWYSWRHQIVEFQKDYWCVAIDMRGYGDSERPEGVASYQIQHLVADIKDLVIQLGREKCILISHDWGGLIACQFRNQHPEMLHGLVMLASTSSTAWVREIWNNPEQRKQSWYVFMYRAPVIPEKALLMNDLEIYEKVMLLPGKTNTDKEDIECYKYWFRKPLALTPPINYYRANFRFDMPEIVEHKENVPMLVALAANDLYLSHSLLDTIKKEYSTIETAIVENASHFLQQEEPEKVNKLIRDFLSKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8X6</accession>
    <name>A0A835G8X6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000279">
        <property type="protein sequence ID" value="KAF9410073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8X6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="80447" checksum="75F0334E07283F4F" modified="2021-09-29" version="1">MASKSKYTARIASVLRWLGSAVLNISRQDRVQALLSRYDSLESKLTELYDAHQAILELGLESEVMDKINADIDQADDLADQIRQAVGTLKMSSLDERPPKVEEGASPALISRLPKLDLPHFGGDLCQWVAYNNLYESLVHSRRDLTPAQKLAYLLASLTGEAKGLVQHLDLVDGNYEIARDLLMRRYQNVRRLADSHVSAILDLPKNPMPQLLRTRLLNPLLIAVNGLKGLDLPVSSWSFILLHIVLGKLSHELRNRFELEHGGDSTTYLPPFDDLVSFLEDECRRVENVPQPKSMEVRTRVQPARIERRREGRIYNSTAMQQPSSRCMYCKEPGHGTPTCFKFGQLRWQARRNIARQRNWCYSCLGNHLASQCQIARPCAQCGGNHHLLLCGNRNGSPPPAASAPKAVATEDRIIGNINDQWTGRAGFGLPQGCPNIPHLYRKKIPLRDTQCQFQSSTGGGTRVPLGFVMQLWIRNVDVALGCHCTIWIGLVWIDNLNMQVRYIVPPSGNPSHQHWTPYAAHDTSVSVGSPSGEKVTARALLDSGAQGCIASTWLVERLRLRVESGGNYIRGVGGVKVPGLVGQVALSFSPCISVATDLGDIIMGPVLSPCPLQGEDDNLQVGLSLAESVQRFWEVEEPPSAPRQNPEHLECESFFQNNTGRLCSGRRGRILRLFLGSDGVPRVAEVLVGDSILKRAVAGNEYAPIVLEAWSNSEAILGRMVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9V3</accession>
    <name>A0A835G9V3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_008939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000184">
        <property type="protein sequence ID" value="KAF9412576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9V3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="503" mass="56141" checksum="BE0093FF334C3D9B" modified="2021-09-29" version="1">MEKCNYKEIPNNNEPFVKLKTSSDWKPFLKQLLICSGVWTSVFLYGLSVGAPTVFIPQIRKEANNTEIITTEMASWMTSAFGFSGFPFVMILTILTKFLGRKIPFVIAVLDSLVAFIVLYFSTNVTQILISQLMQGLFCASHTSITIMIMTEYISPKYRGIFLTAKTATFYWGVWASNTIGTFFHWKNIPLFGIIFSMYTLLTLMIWPESPYWLASRGRFEECAASHRSLKGCDEESEKELEALINSQRQYLASSLTNKQSVTRHITGFFKIITSKGFCKPTALSILTGLLAFCSGKLVFALYAVDILKKVTNNESTAYIAMLIIDGFTVVSMYAGCALAKHLKRRTLLLGASTVGAVFLFILSIYLYCIKLKVIPENQYVTIGLFVAFTIAVSCGPLSVSISVYGELIPIRSRNLSVCIIALTGKLITGMSLKMAPFAFKTFGVHGTCLMFAIFSVITIATLYKYLPETKNKTLQQINDQIMGVKPNTRQITGKLINDDKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAE3</accession>
    <name>A0A835GAE3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_009770</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058856">
        <property type="entry name" value="ASCC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26582">
        <property type="entry name" value="ASCC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="450"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="673"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1300"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1503"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="2135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9411423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2135" mass="244189" checksum="1E8C76EE05185EF3" modified="2021-09-29" version="1" fragment="single">AKGTMIELPRITRALRAHTQLDKPRCLKPKVDPTKPLQLKKKNLQRFKSYTDIYNYVKQNEPDSADILKLFPQLKEACKLLTGDQSDEIIEDAAVLTLRMFLDQDIVMLKHMSQLRQTFGTVLSATANKICEIVTKISEQLSDNTKDYIRTEEAETNKENIKLWGDHIQCHYIPYKPVKKPLAKLTSKPATSSAFVTDFSMKYDSDRAAKATAGPSKVTAPIPESKYGKTWLETKVKEQYENVAEISSVDILQSIITLLNSPRTNDEMQNDLFELLGFDKFEFIQEILEHRQDIINSLKAPPAGPTLSEIAALLPENKMPQYLCQVSVLSEQEKMLAKLAELSKPVVPFSTSSRSSNVDPILQKISYFQTKVQYPNVYDSSINAKNSAGFVSGLKLILPENAVRKDTKEFEEVTIPKNDPPPLTVGNQRIGQMAFENIKELNRIQSVVFQTAYNTNENLLICAPTGAGKTNIALLTVVHQIKQHIENNVIMKNKFKIIYIAPMKALASEMTASFGRRLKGLGISVRELTGDMKLTKTEVQQTQMIVTTPEKWDVVTRKGATDTELASIVKLLIIDEVHLLHGDRGPIVEAIVARTLRQVESTQNMIRIVGLSATLPNYVDVARFLRVNPNIGLFYFDSRFRPVPLEQQFIGVKETGSGGGAHLRTMQTMNEICYDKAVEMVQKGHQVMVFVHARNATHQTAMILKEIAQKKGHLKHFEPEDSGAFLKAKKSISSSPNKQLGELFASGFACHHAGMLRSDRNMVEKYFAEGFIKVLVCTSTLAWGVNLPAHAVIIRGTEIYDQSHGTFVDLSILDVLQIFGRAGRPQFDTSGTGIIITTHDKLTHYLKSMTNQFPIESNFINLLADNLNAEVALGTVTNIDEAVEWLSYTYLFVRMRINPQVYGLTYTDVQDEPMLETKRRELITAAAMQLDNTHMIRFNERTGQLNITASHYYITCETMEVFNSMVRKSMTQGYVLEMLTRCSDFQQLKVRKEELTELWNLKDQYCELRIEDAPEDIHWKINILLQTYLSRGRVNGSSLQSDLNYISQNAVRIVRALFEITLRKNNAYMAGLYLKMAKMLELQQWDFYSDMRQFNCFTIETLKHIEYPMLKPDQIRDMDWKEVGDLIRNPKNARHLKKCADEFPLLEMEASLHPITRTVLRIRLSITPNFKWNDKYHGKAPEAFWIWVEDPETDIMYYHEYFLITKKQVVTNEPQELIITIPISEPLPPQYYIRATSERWLGSESVLPLTFQHLILPETHPPHTDLLELQPLPVTALNNPNYEMLYNFSHFNPIQTQIFHCLYHTDHNVLLGAPTGSGKTIVAEVAMFRVFNQYPNCKVVYIAPLKALVKERIKDWKVRLQERLGKQVVELTGDVSPDIRAIRNSHVIVTTPEKWDGISRSWQTRNYVRDVALIVIDEIHLLGRTEDPTNFIESHTSRRLRIIGLSTALANAKDLANWLNIGEMGLYNFRPSVRPVPLEVHISGHPGRHYCPRMMTMNKPTFQAIRTHSPCAPALVFVSSRRQTRLTALDLIAYLAAEDNPKQWLHMQESEMEQILANIRESNLKLTLAFGIGIHHAGLHERDRTTVEELFINQKIQVLICTATLAWGVNFPAHLVVIKGTEYYDGKQKRYVDMPITDVLQMMGRAGRPQYDNEGVAVVLVHDQKKNFYKKFLYEPFPVESSLLEVLPDHLNAEIVAGTVQTKQDILDYLTWTYFFRRLLKNPSYYNLESVEPQDVNYYLSNLVQSSLDALANANCLEIEEDLRTVHCTWMGRIASYYYLSYKTMAHFTRNLHNNMNIDDLLRVLADSEEYATLPVRHNEDLLNGELSQQCRLPVDPLSLDSSNVKAFLLLQAHMTRLVLPNTDYLTDTKSVLDQTIRILQAMIDTSAENGWLSVCLSCQMLMQGIVQARWPTESPLLTLPHIDSQHLYIFSKMANDTHKPCNMLNGLKVVCMRNYELLAKYMRREFEENQIEQIHRAICDMPTLDVKLSVRGLWFDGEGEQDKLVRQPPARDEWLPLHADQEYTLLIELNRRGGNPNTVLCPRFPRGKNEGWILTLGTVDDGELHALKRVPPKGTTQVTFYTPSRKGRIIYTLFVLSDSYMGLDQQYDLQIELIDPLPSENIDRVYNIDKTIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAI5</accession>
    <name>A0A835GAI5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000267">
        <property type="protein sequence ID" value="KAF9410337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="134" mass="15243" checksum="78ACEFDDE12E2DE4" modified="2021-09-29" version="1">MKEHYDTTAAYAQAKLAQLMSARYINKIMEEDGYPVKCYAVHPGIVDTDLFEHTMFKKAFPWLMKVFFKTPAKGAVSVLHACFDKHIEKKGGLYISNCIEGISNSFSKKLDYQEKLYDISCQLVGIDKVNFGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAJ9</accession>
    <name>A0A835GAJ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000283">
        <property type="protein sequence ID" value="KAF9410006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAJ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin C-terminal" evidence="11">
        <location>
            <begin position="158"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="282" mass="31459" checksum="92573E78490B2D19" modified="2021-09-29" version="1">MPRTKRPVRKQEKTGEDDDALKKLNKLVTDQKNKIDSRAHMELRNVELAFKILLGSISNVYLQKTVGQLKSELHLKEVPSNTRRTRHSSRSASHDDGYLTENSSQGSGGRSKRQIPVPTTVGRSTTGRSTATARRSRSADASCRKLAPPTANKTVQRRRSRSVYRTPAYNKNSAVNYPAITPKVTPQTPLTVLRQPRQGEMVVSMSGSPVMVPSCYTMKPDEMANCNILLQDGTMLSLQPKQLRQSQAYIPFSLMDSNVLNQLKTLKDNLDKVVKLGEKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAM5</accession>
    <name>A0A835GAM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000274">
        <property type="protein sequence ID" value="KAF9410177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15392">
        <property type="entry name" value="7tmA_PR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF73">
        <property type="entry name" value="RYAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="65"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="439" mass="49304" checksum="D764DC3D2BE15165" modified="2021-09-29" version="1">MANENGLGYNYSCINCHNDSYYSYNFSNVDDFVCVLHGDDDLTTSIFKVFVYVMYIAVFVTALVGNGLVCTVVQTTARMKTVTNYFIVNLAVGDILMTLFCVPFSFVPTLLLRYWPFGAFMCKAVNFSQAVSVLVSAYTMLAISIDRYIIIMHPLKPRLSKTAAKLVVFGVWSGALVTAAPIPIVSKLQRPSLWHQTCEVDICGELWSSTEQSRQYTYALLVLQFVLPLSALVCTYTRIAHTVWGGRPPGEAQDARDSRIQHSKRKMVKMMLTVVTVFVMSWLPLNIFIVLWTVHENDDEWALWPGMPYVWFACHWLAMSHSCYNPMIYCYMNIRYRQGFQEILSTLLCLKKKDSTRPCQRSSVCEGIPMSELMGANGTGTANRRGIFVCRCQTSKTTAVSNGSRSTTCNFCTPKPASRSSGVSLTPPVRAASVRSQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBI9</accession>
    <name>A0A835GBI9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein M</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBI9"/>
    <dbReference type="OrthoDB" id="25165at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF7">
        <property type="entry name" value="SELENOPROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032724442" description="Selenoprotein M" evidence="5">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="6">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="109" mass="12463" checksum="11D8550479400DFB" modified="2021-09-29" version="1">MKFTLLAICAILATSFAYENSDIVSARIETCRGCSLNRLPEVKRFVMDDAPNYERVEVNFISGAPPELVLLGENDRELERLPLSQLTRQQCNELIQERGFTKKNKDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBL5</accession>
    <name>A0A835GBL5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000196">
        <property type="protein sequence ID" value="KAF9412225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="286" mass="32288" checksum="CE0AFA5C6692C6C2" modified="2021-09-29" version="1">MQMSRHVLSTNEIADALEAFDDDEDIQGIDIYIDPPCDGTISEGDSELKNVKTAVSARESYGDDAVGYVQLYRDNGICTVKCKMCPEHKVRTKAYNVTLIVNENDGEIISCECHDCAASAGGCKHAVAFLMWVHRRSEEPACTSVECYWKKPALSRVGTTLKFITIEQMTKTLVPHRPSTSALCEDFILEAKKRKINKCELLKYQNDFVHSDITRYSLHSFMVNLPQETKNDVGLLLSVMKSAFTSDIIKNIEEATRQQNKTNFWYELRYGRITASKAHESDHVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBS1</accession>
    <name>A0A835GBS1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_007991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBS1"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="476" mass="52085" checksum="A1782290D3929656" modified="2021-09-29" version="1">MGIKFLEVIKPFCSILPEIAKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWIRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMVITVGQAIVYVMTGMYGEPSEIGAGVCLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPATVNTGRGTEFEGAVIALFHLLATRPDKVRALREAFYRQNLPNLMNLLATVLVFAIVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLAVKFSGNFLVNLLGVWADVGGGGPARAYPVGGLCYYFSPPESLAHIAHDPLHAVLYIIFMLGSCAFFSKTWIDVSGSSAKDVAKQLKEQQMVMRGHRDNSMIHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEMGGMSTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC09</accession>
    <name>A0A835GC09_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000141">
        <property type="protein sequence ID" value="KAF9414151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032697520" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="161" mass="18429" checksum="A31BD8EC59852269" modified="2021-09-29" version="1">MLQNWLLLLLAVTSVLCFPNWYETKKFKVGIEYENSLPMKGGSDRYRHRNNYDPFFVTITAQSKKGFVITYLQVTATIDSGGQLDFKVVQGQTGSRTMIFQLVSNHTDFLSYSYLSYGIREEEYKKMANIITLPRPTNKGLMLQNTGFSIVTLLSLIMCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEU7</accession>
    <name>A0A835GEU7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000148">
        <property type="protein sequence ID" value="KAF9413894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEU7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="183" mass="20356" checksum="4706BA0E9C9F2270" modified="2021-09-29" version="1">MPKSATEDYTRSSDKQRSLSRSTTGLQVPLHFAIHRPGCHFESCCGICNLFPGVLLIAFCQVLVGSILLTLILTHGPQYDEMHMTPTTQFISLATGIVLSGITGAGILLIVVALTENCRAMLVYLLVATIVWLGLVSLAITKIGRACIRFKDVLYFFSIVVVFSFYHFRYVRRAILLHENECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEX0</accession>
    <name>A0A835GEX0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEX0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="230" mass="26080" checksum="1E221A15285D0AEC" modified="2021-09-29" version="1">MELIDNEIRQWDAADVKEQFGDNLTLLPLNDNIKELQTILRDKNTSRSDFKFYADRLIRLVIEESLNKLPFTDCEVITPTEHCIDLNMVLVTAGASKSYRQVRRGYGTGLYSSIGLRDCCRSIRIGKILVESDTDTHEAHVVYAKFPEDIARRQVLLMYPIMSTGNTVKQAVNVLTQHGVKEERIILSNLFCTPAAAQAVVDYVPKMKMLTSELHPVAPNHFGQKYFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF77</accession>
    <name>A0A835GF77_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="548" mass="63831" checksum="2B1F4552D8F3F995" modified="2021-09-29" version="1">MKEDKEQKFKKCAVMFVVMNESRIMKAIYKRDLSGNARGDRSKGTKILTWLRRFLIKKWQLLDIACVIDSDTENELLIQPSDLQIEMDENFEIGSFNKSRPQITSPSILGPDTSATSSASGASSECSSPSSSVMSGRKRRKFTIDVTKKRRKCNKENWIDTKRKLLQNLGKKHLSRKGKEQKGKDMRPSCDNCKFKCDTKISEESRKQVFDLFWGLGNHVKQWEFIGKYTKRHMKRRITTDNESKRTQSVHYFLPLLLSENDSTVKVCKLMFKNTLSVSNQFIQSAMDKYDKTTGFCEEDRRGRHGKQTKLLTETVIQSVCDHVKSFQPVESHYTRKDTNKLYLDSSLNFSIMFKMYKTWAEENNLTDIVQTLRQYRDVVNSHMNVGFFIPKKDQCDQCTANKNNPPNESQEQITFAKHIQNKNSILNQYKWVKNEDGDKVKWNQVREIVVENSQPDKIFYKYDLNEKSALCIDCSKRTSRRVTQGNTLELRKAYGESLPITTAKYKDLMSLCQKNLIPPRYHDYYKNIKHTSAMSESEAADDLEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGH4</accession>
    <name>A0A835GGH4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000103">
        <property type="protein sequence ID" value="KAF9415737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGH4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="413" mass="48196" checksum="0EE29B2A04D61F66" modified="2021-09-29" version="1">MTTAEKGDYLSFGDRNNGLSTIKTWHEHNQMVLKGDIIKTTDKNTAITKNSIIKVNHTSCEDFSDSTDQLRHRARHINYWKAELERAIRDMDAEINILEALRQQLKNAMDTLKIPEYINEECLDLRRMRMQSDLIYDEPQEDLFTESALIENVKKLHRDLLRDIEYQLDMNVASKNWLERDWSDKHLAFKYESENAYLETKAENVKDSAGATRLSEGQSNVPSWEQFTINALNEFKISIDKSKALRAKVDAVLINTSRDLRSQDIKVNKSLSERIARTEQVKTELENQLKLTLEKIVETENILEMLHEEMLKVSQRIQVAQTRLNTKNCRPNVENCREGSLVALIEEVRDLNDSMSLLQKRSLETEKLRAELIHERSILENEIIVKKKTLHLDNERCLFLRSHYQSAEKMCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGK5</accession>
    <name>A0A835GGK5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="606"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124475" checksum="7D38B53CD51F977E" modified="2021-09-29" version="1">MDGERKSDMADGQTPKNSDTSSIADKRKGSVMDQPIDLDYVLVNEIGQFGRYQMFNLLLVSVPIIMSAFMSEYIFSAAAIPHRCRVPECGETTKTERFNPNWVLNAIPPASNNAGFASCDRYIPIFNNGSLDYCPSSLFQQQTQKCDGFVYARDNSCVYDFDLGCQDWLRALAGTLNSVGTLLVLPIAGYISDTFGRRVALVISVVNLGLFGIIRAFSVNYPMYLAFQLLQTTFGAGTFSSSYIFATEFVGPKYRVLTSATCTSMFAVGQVILGAVAWVIQPWRYMILALHIPCFIIIAYYWILQESVRWLLSQKKYDQAKDVLERVARRNRKQISEKSLHALMNPPEPVKVVNGDEPNLFQAIFRSGVLLRRVCTTPIWWITTTFVYYGLSINATSLSDSMYLNYILTCAIEIPGFYTAVLILDRIGRKPTLSGGYLFSAACNIAFAFIPNDLSTLRLIVYLFGKFGISVVFTSLYLFTSELYPTQYRHRLLAFSSMVGRIGSITAPLTPLLMDYWDGIPSVMFGAMGILSGILVLTQPETLEGKNNRADGPAPENVDSSNIADEPSAHTSQFEKRKGSVMDQPIDLDYVLVNEIGQFGRYQMFNLLLVSVPIIMSAFMSEYIFSAAAIPHRCRVPECGETTKSERFEPEWVLNAIPSADNNAGFASCDRYIPIFNNGSLDYCPSSLFQQQTQKCDGFVYARDNSCVYDFDLGCQDWLRALAGTLSSVGTLLVLPIAGYISDTFGRRVALVISVVNLAIFGIIRAFSVNYPMYLAFQLLQTTFGAGTFSSSYIFATEFVGPKYRVLTSATCSSMFAVGQVILGAVAWVIQPWRYMILALHIPCFIIIAYYWILQESVRWLLSQKKYDQAKDVLERVARRNRKQISEKSLHALMNPPEPVKVVNGDEPNLFQAIFRSGVLLRRVCTTPIWWITTTFVYYGLSINATSLSDSMYLNYILTCAIEIPGFYTAVLILDRIGRKPTLSGGYLFSAACNIAFAFIPNDLSTLRLIVYLFGKFGISVVFTSLYLFTSELYPTQYRHRLLAFSSMVGRIGSITAPLTPVLMDYWDGIPSVMFGAMGILSGILVLTQPETLGTKMPDTLAEAEALGKPESKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH93</accession>
    <name>A0A835GH93_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="370" mass="42387" checksum="FCBA681CD3F41E0D" modified="2021-09-29" version="1">MKSPLPKECPFNDSDWKALEGIIDNELSSDRNLKPDDLNCNLDNLLELQTISIPISEVTPIPSPYKDFDSPDQTSSLSTSTPDQEETQPEVQNLNTNLVSPSMAIASVASLITISECNSPVMTVSECESPSLVKKRNRKSTFKAKPGKKRKCCKENWIDVKRKTAVNTGQQYVSRNGKVRQKKVMGPICKSTCKLKCYEHFNEATRQKIHSSFWQLADHSKQWEFINKFSKKLRKRRFTTESTSRRHFTTQYFLPISSESQNPHCEHRRVCLKAFLNTLSITDQFVRTAHQKLNEEGITLPDNRGKHPNHVIKIDSDMIKSVCDHVASFQPVESHYTRKNTSKLYLDNNLSMKKMFSLYKDSTQSEDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIU0</accession>
    <name>A0A835GIU0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="1">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="342" mass="38523" checksum="124A4B9574D11D9E" modified="2021-09-29" version="1">MFESDDYDQVLSQFEFPEDVLAVNTNNVESKCGSKNTNVDVKNDAVQNLQTNGAQVLKLNENIPKSIELLVRTNENIVNNSKENVKNANSVVSPKHTKRKMINSYFDHKSKRKFPGPAGLLTGGFEENENICQIELLSQDVDFTQNSLRGDLFESPLWVRLLDDLKSWNLHDVDSIKTVKQQAMSGNLRRRKAHTITAFVETVDRSATDPLIIMRDTTGNIKGTLHRDAWSSFSKYIASEYCAFILWKPTILTTGSAFKKHYLNITLSNILAVYSSTVLADDAEAKPLPDGYTIVYEEDYTVIKTEKNLKNIGTNETVTNGFDSNTSDLLEELDTIFSDDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJR0</accession>
    <name>A0A835GJR0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJR0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032773926" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="7550" checksum="4B695755D098EF4B" modified="2021-09-29" version="1">MFKDLFLALLVIMMFGYSMQQGFGSGGAGAGGGANAGFGFGFGANAGAGGAGGGWNGGAGGEQGNPSGHNAGFGFNAGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-11-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJR3</accession>
    <name>A0A835GJR3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_003978</name>
        <name evidence="2" type="ORF">HW555_004745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJR3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9630687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="399" mass="45359" checksum="CF5342D573D12CC2" modified="2021-09-29" version="1">MDPQRTTLPGPLPASSKQAARKCFAITNTYIKSTKKEIVSVHTSTPTVENLSFQIEQNQIYQGDVNVLSIIDTNKEIMCCKYTEDVNEIAAGFNDGTMRVFSCNTGHCIHTLVDEECRAYPGPVTSIKHRPVSKANPITNMLLSSYVNGCIKCWKYKYDQCLYTIREKRQTLGLNYHPRHSKFVTYGDDAKLNMYDEEAQTQERAFYSSNQRNKVDGHTSRIFACAFNPRSQHEMISGGWDDTVMCWDDRQPYATRYFVGVHMCGEGLDFDKPGRTILTCSWQEKDSIQLWDYGSCKLIETIVPDNYQSKLYCGKMVPHTNLIVCGGSDSNILRVVDINMKVTECCIRNNQGGIYAFDFGTIRRKPSKVTETYKKISEIPNVPRVSFVTGKRLQTVDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK26</accession>
    <name>A0A835GK26_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA (pseudouridine-N1)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_010057</name>
        <name evidence="14" type="ORF">HW555_006022</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:13933"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000008">
        <property type="protein sequence ID" value="KAH9645858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK26"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9645858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="26491" checksum="F7445007A4A05AB4" modified="2021-09-29" version="1">MGKKRKVATNDEFEFDPIPRHLVTKHIKKQEKRLIIVLENSQIETVKTGNSFELLNCDDHANILRKNNRDPGSCRPDITHQSLLMLMDSPLNRAGLLQVYIHTEKNVLIEINPQTRIPRTFKRFAGLMVQLLHKFAIRASDGPMKLLKVIKNPVTSHLPVGARKVTMSFSSTVVKNCRELVPKDEPIVIVIGAMAHGKVEVDYSEDVISISNYPLSAALTCAKLCTAFEEVWDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK70</accession>
    <name>A0A835GK70_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK70"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032422156" evidence="2">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="269" mass="30839" checksum="48B04A58041E53D1" modified="2021-09-29" version="1">MRLLVFSILFSFVFLVSCKSHVKSLNESMGQEVIEVVNPIKELPMGLDEEPASEKADKIKTRESQPPKGEYKRISTISGKENMKDIDKIDGVTTENEEDRIEKELAEIYKDTADYKNENVDEDVAKEVTIDRHTQETTAKEFKTKYDAETKNDSYEDTDETTLKPTAVEDEQANAPIRRRGNNFKLQPDSTDKDDIERFRTSVDDINCNENQMLSKVAPDYRDDEESYANSQNIYANSRSSSGEAFNTVASRQLIFISVLFKYFLYISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKC1</accession>
    <name>A0A835GKC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="602" mass="66517" checksum="E5643C2329A2D7DF" modified="2021-09-29" version="1">MMNILHAISVFEVKVLFPLIRLVQIAIVSLFPSDNSLYPTQANVQDSQTFDFIIVGAGSAGCVLANRLTEVSDWNVLLIEAGDDPPRASIIPGLSIIVASALPDWNYYTVDDGYSSQGLKTKTIHNRKGKMLGGSSGTNFMYYVRGNKIDYDKWAQDGNEGWNWNNVSKYFKKSEKIKSESIMKSDAADLHGKDGFLSVTQPDWGDIPKDYLNAFKEQGHDILLDYNGHQQLGYGMSSFTSDEIARQNTAFSFLSPIKTRKNLHVLKNTLARKILLDTNKRAIGVEARLPGGQIIKLKAKNEVILSAGAINTPQLLMLSGIGPKNHLEEMKIDVVLDSPNVGQNMQDHALIPLIISGEKKFISILENIKPLGETTRFPMASFLGFVTLNKSQSYPDYQVTAVPTPTGALLPPLLCSDTFSIKDNSIIALADKTQTRGALFALVTHLHPKSRGRINLRSTNPEDSPLIYSGYFSNEDDLENFAKYVEDYITVINTTYFKQIEAQVIDLKIDECKGISFGSHEYWRCYVLNLASTQYHAVSTCRMGVEGQGVVDARLRVRGVTGLRVVDASVMPSLTSGNINAPVIMVAEKAGDMIKEDFGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL02</accession>
    <name>A0A835GL02_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immediate early response 3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_014897</name>
        <name evidence="11" type="ORF">HW555_003747</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000418">
        <property type="protein sequence ID" value="KAH9638036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL02"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033046760" description="Immediate early response 3-interacting protein 1" evidence="10">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9638036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="9332" checksum="6C4A4B6E5D98C0CA" modified="2021-09-29" version="1">MLTLWNLFEASLLCLNAVCVLHEERFMQKMGWGSNNPNQGFEDQSTVKFQILNLVRSIRTVTRIPLIILNILTIIFKLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL35</accession>
    <name>A0A835GL35_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL35"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="77663" checksum="1830F937DB43765D" modified="2021-09-29" version="1">MNDSDEFLSLCNEASTSSSNNVVENVGKNLPRILDGKFFQFCKEESTDRKRVGMCTLCLPKQVKISGTLPSTSNFVTHLKRKHGESALNDYKTYFASNKKTKKTSPETQLQSKAKASQEEFNENIVKFFIHSLIPLRAIEDPYLKKTYENAGMCQNGLTLMSRRSLGRFINDYYIKEIRDIKTVLQDTSYVCTTADIWSGKKRSFIGVTAHWITSSLQRESKTLACRRFKGTHSYDRIAVLLENIHSEFGLDSRKVLSTITDNGSNFVKAFAEFGVEIDSINSIEIVEFEDKDSEIEDIFNASEDDVQSEVSSTTSHDKSETDPLSIENVNVSPELPAHLRCSAHKLNLCATTDAGKVLRNQNTSLSKTHERVINKCNKLWNAAGRPKSAEIIQTVLGHTLSRPGDTRWNSTYDALGQIYAIKDKSIPLYETLKISCSSQLRHNEFHYIQEYLKCSKPIADALDFLQGEKDMYYGLLLPCLLSLRRKLQKLCNENFVYCNSLARTHLESVNNRFNDIFDFCTTKAQNAAIAAMSLPRFKTKWFSCIPTEEHQRLKSFFKAAIAKEVSENTDSSSAMKNQNKNDFFQFDSSSSDTEEDVYRVQRSKADLIVSYYLSDMEQDLNALHRYPEVKKVFIKYNTPLPSSAPVERLFSYATMINHPKSHKLSDEMFEKRVVLKANLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL75</accession>
    <name>A0A835GL75_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL75"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="405"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="625"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="706" mass="80212" checksum="783824CE66700702" modified="2021-09-29" version="1" fragment="single">MPKQKKQKVWRHYHSLPDKSVKCTFCSKMYRVPNVTKMGTHLLKCPKCPLVIRNELTESCEETSLIASNTTNSAITEGGYVTSTPSDATPLLEFTEEKKRRLTKLLSKAIYVTGSPLSMVEHPLWREFFKELQPLFELPTRKVVNLQKAFDLVKLEHPNVITLNCVAHTLNLLCHDIMKEDAIEAFISVAIDVIKSVKKSQILCALFKQIIAEKGSGEQLKLPSKTRWGSYFHAVRSLQNSKAALQCLAVHEDAKMIPADIKAHLLDEEFWKMIDESTAILERITDYIFKLEGNESYINDVYMAFKDIKSRLVFLLPGFSSLFDDNIRDRILNAVDKRRENCIKPIHLAAYMLDPKCQGIEMNEDEEIIAMDFIHEKGRQLNLEVITDLANYRAREGFWAKSFVWASLQNMKPLTWWKGICKNKALSKVAACLLTAPCTSAATKRTFSIHGNIHSLKRNSPSTIKNIEPQPSTSGRNTRQIEFCDVTKILSDNSDLDKQLCRSLTGLFAIESDRYIMPAVKCGGCAKYLSPIDAAKCNQCDALYHRACVCLPSTGPISTTWRCPECNKNLRRDNKADTPVRARAAQVEEHLSSEELMETSTISCTTLDTTNNLSPDLAVELRQFKEELRGEFRLMHQEFQQLRSEMAQLKESIKTSDERMESLEKLEISDPQTLSISDDYAMQGTQSCVMDSVGSRFTRLSNERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM20</accession>
    <name>A0A835GM20_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="23956" checksum="06E8A3413BD365BB" modified="2021-09-29" version="1">MEFDIIQCISISVTTTNMFKYFVFICMMAVAFADPKPGVLYSAAYTAPVAAAYTAPVVSAAYTAPLAYSAYSAPLAAYSAYPYASPYAAYYLRKYPIVCIIQCSTSSVKTIKMFKSIIILACMLVAAFADPKPGVLYSAAYTAPVAAAYTAPVFFLACVMAVAFADPKPGVLYSAAYTAPVAAAYTAPVVSAAYTAPLAFSVYSAPLAAYSAYPYASPYAAYYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM85</accession>
    <name>A0A835GM85_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol carrier protein 2</fullName>
            <ecNumber evidence="15">2.3.1.155</ecNumber>
            <ecNumber evidence="16">2.3.1.16</ecNumber>
            <ecNumber evidence="4">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Acetyl-CoA C-myristoyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Non-specific lipid-transfer protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">SCP-2/3-oxoacyl-CoA thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">SCP-2/thiolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">SCP-chi</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Sterol carrier protein X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="43" type="ORF">HF086_001674</name>
        <name evidence="42" type="ORF">HW555_004899</name>
    </gene>
    <organism evidence="42 44">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="42" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="42">BAW_Kor-Di-RS1</strain>
            <tissue evidence="42">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="43" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="43">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="28">Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="function">
        <text evidence="29">Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:47400"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:87695"/>
            <dbReference type="ChEBI" id="CHEBI:87698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:47401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:40343"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77081"/>
            <dbReference type="ChEBI" id="CHEBI:77084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40344"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:62960"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:16865"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57373"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58507"/>
            <dbReference type="EC" id="2.3.1.176"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:16867"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:35279"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="35">
            <dbReference type="Rhea" id="RHEA:35281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="38">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:46344"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:86042"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:46346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="42">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="15"/>
    <dbReference type="EC" id="2.3.1.16" evidence="16"/>
    <dbReference type="EC" id="2.3.1.176" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000286">
        <property type="protein sequence ID" value="KAH9640322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM85"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="39">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="41">
        <location>
            <begin position="267"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="40">
        <location>
            <begin position="427"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00032093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00033178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00045738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00045994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="EMBL" id="KAF9418193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="EMBL" id="KAH9640322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="535" mass="57512" checksum="1309312408C85A16" modified="2021-09-29" version="1">MPRKVFVVGVGMTNFIKPSTGPDYPELGKEAVLAALADARIKYTDIQQAVCGYVFGDSTCGQRVLYQVGMTGIPIFNVNNNCSTGSNALYLAKKLIEGGVSDVMLAVGFEKMAPGALAAGVFNDRTNPLDRHTLKMAELAELTGAPMTAQYFGNAATEHMKKYGTTEVHLAKIAAKNHRHGSKNPRAQGKREYTVEEVLNSRRIYGPLTKLECCPTSDGAGAAVLMSEEAVIRYGLQAKAVEIIGMEMATDTPAVFEENSLMKVAGYDMTALAAKRLYQNTGVSPKQVDVVELHDCFAANEMITYEGLQLCGEGEAGKFIDAGDNTYGGRVVVNPSGGLIAKGHPLGATGLAQCAELVWQLRGEAGDRQVPRAKIALQHNLGLGGAVVVTMYRKGFTDIAPNAVAVAGNPEDFKVYKYMKILEEAMANDTDNLIEKVRGIYGFKVKNGPNGAEGYWVINAKEGKGKVTYNGSEKPEVTFTVSDEDVVDLISGKLNPQKAFFQGKIKIQGNMGLAMKLTDLQRQAAGKIDTIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM95</accession>
    <name>A0A835GM95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07852">
        <property type="entry name" value="STKc_MAPK15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000238">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="546" mass="61593" checksum="38415993D5C1473F" modified="2021-09-29" version="1">MSQNQGKKEDRKKDVGQKQLQKKVPDKNMSEIDDHILKRFEVKKRLGKGAYGIVWKAVDKKTKDVVAIKKIFDAFRNQTDAQRTFREIIFLQSFRNHPNIIKLHSIHRALNNQDIYLGFEYMETDLHNVIKRGNILKDIHKRYIMYQMLKATKYIHSGNVIHRDQKPSNVLIDSACRVKLADFGLARSVSSLYSGGEEGADPCLTDYVATRWYRAPEILIASKSYTKGIDMWSLGCILGEMLTGKPLFPGTSTVNQVERIMSALPKPSAEDIAIVCSGYGSSLIREQASNSSGGASLTALLSCAPRDAADLVQRLLVFNPAKRLSAERALDHEYVAKFHRERDEPTLMSDVLLPLRDDKQMSVDDYRNKLYSIMAKGSQSHTGQHRKIHSSNKTHPLPTTTSKSSKNFHETELTKSYSKTKHLSASADTKSRPKLTRPQLERPLKEQKSEQSVTKPLRATKIFEQRHEWVPNTNCHGDYFQPVLRQSPSETGCMSGGKKSTLQHRRNSTSFSTVTIGGDAEYGSCGKQRHGVITASALMDLRTSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMM6</accession>
    <name>A0A835GMM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAR DNA-binding protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_003979</name>
        <name evidence="17" type="ORF">HW555_004744</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMM6"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000098">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000107">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="191"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9630688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="44829" checksum="632653D6E0CF4820" modified="2021-09-29" version="1">MSFEYLPVAEDENEEPIELPIEDDGTLMLTTVSAQFPGCCGLKYRHPETKIIRGIRLREGRLYPPPEGWGNHLYICSFPKESKRKPGENSESAATKNKRNDNLCSDLIVLGLPWKATEQTVREYFEKFGEVLMAQLKRDPKTGMSKGFAFIRFASYTSQMRVLAQRHMIDGRWCDVRIPNSKEGSVASMPCKVFVGRCTEELTANDLREYFSQFGEVTDVFIPKPFRAFSFITFLDPEVAQSLCGQDHIIKGVSVNVSNASPKQNKSGSNQRSMPGRNYEDGHPHNASNNNSWSSRNMDMVNMQALSLSGQHGQTAVAGGGGQAQGGSMPLGMGGLPVNQALVAAALNQAAGWGLINNIPSGGSEQGAFAGPASSAPPAPPNFLSWMQQGNSAQGPSSQWGQRHQSQGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMT1</accession>
    <name>A0A835GMT1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14772" checksum="61600BAF2C6BF2CE" modified="2021-09-29" version="1">MQLRSDVKKKIDKDQEKAKARFDKNRKKPKSYSVGDLVRIERTVVNKEHQGKSKKLIPKLQGPYRIVKILPNDRFVVEDTPLTRKGNKRYENIIAIDKIHPWLNFNDYSSDDDNEMDSNENDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNH2</accession>
    <name>A0A835GNH2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032879242" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="107"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="363"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="451"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="525"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="755"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="829"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="900"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117425" checksum="1F2ECB9297C44F48" modified="2021-09-29" version="1">MKDITLVLVCLLANVLANLEGVYNNGCPKDTSINKLLPHENCDQYYQCFHGALITRYCPSGLQFNIKRERCDWHGNPNCKSKKVRTEESQQPDSSEELDNSNPSHAGLICSTPESNGALVAHENCNEFYKCSYGIPVSLKCAPDLLYNPANEKCDAFQNVDCNDRIMPIREKYVTSRTRAKITSSASEICANGPDGVLVVHTSCNKFYKCTGGKAITMSCPVHLLYNPVLQHCDWPQNVDCKDRMVNENDESISSNDEIDDSDEITANDEENVEAICANKNSEGMIVPHEKCNHYYKCQKNIPVDFDCPDNLNFDINKKMCDWPQNVDCGERITSDSESDAESYNPQAEFGQHGHQNEPVNVRAICSAEGSDDTLIAHEYCNQFYKCRAGQAITLTCPGKLFYNPTKEFCDWPNFVDCGDRIVPYSENRNNFRNINNVMKNEDLSDPNDAPEICAAAHSDGTLIAHENCNQFYKCHEGKPMALFCQINRFFNPKKGYCDWQHNVDCENRAIPGENNNGDDDNNLNHLCSGSNEGKILPHENCRQFYKCMNGELYPMDCPPGLYFNTMLKVCDWPTNVDCGERFTESQARNTHGIIRRAHGVVVLSLTLMLVNFCPIRFAADSLYALEKEKLVRDCPSGLHFNSELEMCDLPKNVKCNYSQATDLSDSKGDLLQRRIENPAEICAHENSEGILFPHQKCNQFYQCSGDMGYCDWPSNVNCGQRLIPENNDVEAGDGSNNQGGGEHVGNNADPSEAPKICAADDTNGVLVAHENCNQFYKCFAGKPIALDCPSNLFYNPEKGYCDWQYNVNCNNRVIPAENSDVNDNNFANQSCSGKDDDIIFAHENCNQFYKCVDRHMEPMFCPSGLYYNTILKACDWPINVDCGQRIVLLLLCVAFAHANSSCSPDEEILLPHENCNQFYMCVGGMKIELSCGHGLMFNAELQLCDWLKNVDCSDRIIPEEVDGGNQNEDNEPELPVGGNNYDDPSQAPAICAAEDSDGVLVAHEQCNLFYKCFGGQPIPMECPSSLMYNPEKEYCDWPSNVNCGNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNJ1</accession>
    <name>A0A835GNJ1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNJ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="207" mass="23198" checksum="55876D9C3A854E36" modified="2021-09-29" version="1">MITDTTLVNMLKNSPRGSIILFNDNIMMRRRRPWHVYVSQIMSIVVTIRYRSINLSCHVYIPVLLAMVREMLPERCGRACSRARRNVSIASALLCPTSDTPFTDSNWSFVSGDKGFADFAELDEEFKASCSALSLLLSLCSRSSFDELLGILPRMELFTLFWFIAFTILDTRPFSEGLGASTGFIGGPIAFSTYFVGLCWGSTLCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP16</accession>
    <name>A0A835GP16_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_000857</name>
        <name evidence="3" type="ORF">HW555_003418</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000572">
        <property type="protein sequence ID" value="KAH9635136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP16"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033040957" evidence="2">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9635136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="141" mass="15701" checksum="9DCFACC27BFFF826" modified="2021-09-29" version="1">MMKQVVVILTLLVCCYCLESNEQLPEEARAKKKKGILRLLAIAALVVLSKLAVIKVASFFFLVAFFQKLFYLGGVFLTSYMKNQSGPGSTMMYGPPLSQEYNTVGYSYEPADQEPFQPQEGLPGIADVSNGFNWLFSKNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP17</accession>
    <name>A0A835GP17_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Anaphase-promoting complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="166"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="9">
        <location>
            <begin position="792"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="10">
        <location>
            <begin position="1689"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1805"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9420095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2034" mass="226986" checksum="AACEF0DE33582AB9" modified="2021-09-29" version="1">MIAASEPLEFVPHGRTVLAKHPGQIYSKHNTSASENSLLYKLTNFAIKDESLLEARETEEQEWWCIREVYYRNNDDFEEEQQQPKDSKYEFNSESFRAPSRLKNDFNISIKSELMSGMKKMEGDGLNSAGPSRGGSANSSSNMSKKFNLTSGSGSKKSKGGLNPKTDSSYEEELYVKGCTAVWSKGLISMPATKLTDPEHRETIACYTIDNPIKHAAFCNFHVDIKNTMLIDALNTQIGDVKKNIKIEDTTEHIQTKTMPAILLIDNKCMKVYANEGREYITSIPFQVKKVWPMKYGVLLEKEATPLTQNSMLPTSFIKLNESQNSTFSKSKSNFPFNMSSKLRPESVSAFDQDVALPTCFSLTHPLDEVTPILMKSPSQGLQYYNDGDVQIIFVSSNPSIILLYDWKLGTHSLWKIRRTVRDECLSMCPNMNSTTTVFSQSCDYMGSPMQSQRNVTSWATGLGSPYQSKKFPSTPTMSRSRINSPMANVFHQQGLSPHASIGQASYTSMMGNNGPQNPPALPLYPDICLDHIWTDTQTIRRDPIESASDMKTFLHTDLVGHDYLCFIVKVGGVSRLQIVRLQRSHSLGQTSKTNLMVGAVSTVLAKDAVVLEHLNMIALIDEAGNIILQSGNHVVGKVHVGGVLARLIDSPYTKRATFQSPFPRRSSLLPSRCNETSNFDDSALHLLSPVPHSSTARHEQKESLGLCGLCDAAGSRMTLQFEAGPMYRISLPPLTCSTLVTRCYTALRAILPKDITMQVIIKWYGARNAPGTQDLTPDQEWSMFSNLLFSLIGYDVEKLQAKQTDDVEHAEVATKKQRTSSDGSSDDWEYLLNSKMHKAIGQSLSMLKLPVPNSDSHRKNKRSSTEPEKTIQINTNSMLFPYILQVLYSLHLVYEEIKLNTLLWNNLRPLSAFLYQLSKDLKLDAYVNHYWLDFPTDLNLEYDDESQICESSLNKLCEPVYFNREPPNVYSYLNSMLKDLDVGSYPYLAEVNDMSRDIIEILSTVGCGRSAGIQTISSRDTVTASSTPRARRDTNNYSSPYCQAVIMACDKGITLRDVDNLPPALGLLLLTIFSRCKSSPPADWPPEAYNLVMREDLAHQAEVAHTMKTASDYMEFIALEVLEKDTVYTLAKKPVEPARSNPEDADVITGMEHLNTQLLSLLYPRDHRMTEVINLLQSSIPVTINLTQRPEVSDHDFIEEQEKYLFAVSTRTMALPIARGMASLRCVPCPATEAVELPRVCVWGRWRGRGAGAEGAGPGAWPAFHNGAAAALSLVPLSGFTIDSEWVIYNKPRGTAEMSTEHAGFLMGLGLNGHLRDMPFMNIYEYLVKCNEMISVGLLLGLAATYRGTMDVQATKMMSIHLEPLLPPTSIELDIQQNILVAALMGVGLIYQGTAHTHYAQVLLNEIGTQKEKYKQGSFAVREGATVNLDVTSPGATLALGLLYLRSGCSARAAWLQPPRTPYQLDFVRPDLLMLRVIARGLVLWDSIEPTEEWVESQVPDTIKPYCFVKPTEDNIDYEAMNQAYCNIIAGACFALGLRFAGSGDEDARDTALQYAKLFIAVGGKSVAELAGRSTLETCLCVCLLAAGMIMCGRGDIPTLRVCRRLRARTPAAAPPAAAPLTHGGQMAVHCTIGLLFLGGGRATLSTTPTAVAALLAAFFPKFPTHSEDNRYHLQAFRHLYVLAVEARLILPRDISTEKLCYAHIQVIDLNDAVKEMKAPCIIPELSTLKEVKINDPRYWPITFQRDRNWDQLKLFLEYSWCIDIKQRAGCLSYIDDPQGFLTILAQTLTLDKSNIWSTNTENIELFTNDDKIRNFVKQYLVKDVGAKVCGDCLVVSRRRKGRDAALAPCSCRAYTRPERDHLQGLAMLTYDCVVKDILCALPIWTTFLKIIKTMKPEPTSYHIWQIKLLLSQIDNHNRRTMNEMKVDDQEATNEPLISNEFTLAIKQKVSNIFDSWESRLAPFLRKYLGLPSSRKISGCDDDVKKILSGFLVYHDLPKGAMKDAVGDDELSVLLQLEGVSMEGMSKVCDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPS9</accession>
    <name>A0A835GPS9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing family member C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_002828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000001">
        <property type="entry name" value="EF-hand domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="210"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="390"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="729" mass="84986" checksum="AA50588704B50DDC" modified="2021-09-29" version="1">MSIRNPRLPLLPGYGTNPMIGKKNFGVRPIFTTIDKVNMLVDKQEGVNRVPSLYCRKQAPDLPTWIMYDKHILRFQAFFQQTLHENRSGSHILRKVNILFYLEDGTIKVMEPKTDNSGLTQGTLISRQRIRLPFSNDLYYDVLDLNIGLEVSFFGKVFKIVNCDNFTRVFLNRLGINVPDPIPYPDSVERSRDTRKPVKHRPFKQFLDFDRQVLRFYGYWDDRDSEFGTLHNLEIHYFLADDTIEIKETVAPNSGTETSPMFLKRMRLPRKIPPKIEMTGGPPVPSYCPADLSIGAVLNVFGRNVVLTDCDPFTKEYYRVTYGFDTFTKLPIPQDQSKECISSSMAERELPPWNGYGSYDDSAENCRTVEPKAQHRDFIKFLNKDRVGFDSHVLRFAARLITDNPDDIRRYFIIKYFLCDDTIGVFELGERNSGFLGGKFFRRDKMYLPDVNFFVPKEPPAYTDKDMWVGNELVVNKHRFRLIAADEYALRYMELHSEQYPMANIALIMDKIRRTLASQENGYKNFVAKYMEAVEPDKKDLMSVRCFKQALKEVMCEKMTEHEFVTLIRFFRGDPGKDKLPRREMVRSLVFTELTRGLWDDRDRLREGLMHADATGSGALSSDRMRQLLRAHRLPINTDLMDCMLSVLLKDENCNIHYEDLMEFLDFKTRPVFNLSDADYEKVVRHAPPLKDTECKMWSEAEVEIKSGFVNWNAFLCQLNLEHLVKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQD1</accession>
    <name>A0A835GQD1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF6">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="45344" checksum="7E605A94019B8889" modified="2021-09-29" version="1">MEEEQCLNCTLYAEFNDTFYKNITKNETTINKFYFYQSAQLAILWMLLVTIVAGNATVVLALLLTKSRKSRMNFFIMQLAIADLLGVVTYSSTYVLVALSVDRCDAITHPMNFTGSWRRARALILGAWFVSFLFCVPMLFLFDEANVEGIYQCWSGISKLQWRIWMTSVFVSLFVAPALTISACYGVIVVTIRQKSNRVLGRRATATRQYSDDLDSRRASSRGIIPKAKIKTVKMTFVIVFVFVLCWSPYMIFDLLQVYGYVPDTQGNIAIASLIQSLAPLNSAANPVIYFIFSNRIFVSLRNIPPYKWLWCWMRASDSPAGNESRAHTELLTSSHRRTRHELTIRVKDDSVKFPKQRLHQCNSTNSKKVRLHLPDQQINNNCHPAQRRRDDTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQF0</accession>
    <name>A0A835GQF0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQF0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="27222" checksum="89D3C79F28538C2A" modified="2021-09-29" version="1">MAIWSSPERMLPLSEIYRFITDRFPYYRRNTQRWQNSLRHNLSFNDCFVKVPRRPDRPGKGAYWTLHPQAFDMFENGSLLRRRKRFKLHKGEKDSLNAELAALASFNRAFLARQAGAPPAATSLPSSNMYSPASTFISRPSPEPTETVDTTALLPLGPRPRRAFTIDALLEPEPRRSSPSPPPPPPIQPHCPLPLPPPYLLAAQRYHAELLAGLQQSCLPPLWTWRDTSVAECKNRSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQV4</accession>
    <name>A0A835GQV4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQV4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="937" mass="104707" checksum="58ED10C9D1AB7CBB" modified="2021-09-29" version="1">MVRVGAGEAEAKLMLGARVQGCNAAAYTNRVPLIHPMALLHYASAQGGYYAAAVGPPSSLVCGDRSSTWQLWHPSLEAELDAHCSQLSTVARIAGALNVLIDKMREGAYQGTLRVLSRYAASSAVRRRADRCGAYPGAAPRCLPAPHASHHLLLLLDELYALCERGGIAGYVYPVERGSVVRRGARDADWQFDAACVKSCLQQLHHVAGEDIPPSPSDCLETALLSRWESLNREAKASAGSTPTYSKRQLRYLWRVASELLKCKSMMACENHSTFKANLIQVTSLHQEPIEDLIHVLAIMLDQARDLYLNNFHSRNIGEFDRDLSVYRSKKWNKLKDYYDASSACLIDAVRRDPELRREDLKDHLVVMKNILNWLYKGAKDDKKYLGPVLRPYLDGLFTTSIENSWFLEDFDGKKCVQELEGLKEYCMGVHDGSLEPCMGLLDAAKKFAWAKAMVDFVDRFRHIDFRIVFPTGEGMAISYPIKLPSRREHSSARTLTLSRRDKAEAKLRLAKRCVLGAFAAALVGDRRHKQKPISRHESSDEILANVKNGNYWRTTKPDIIPSSSIQDISKDQLDSLPRVRRRSRRHRPATSYGFPEISLSDHADTKTMRRKYHTLKSLVYTEPVESIREIRQRPRSAGSTVKNKEALSRPSILETLDFINSVKSALCVEESGASDAEDSAWSIEDEWLVGQCAPLNLISARSGHHALHLALGDLVVALLHRGRFTILQELCSFLGDASEGALFALHRLARAARSRSSERASSSWRLPEAEGSVTEAPQKYRPRPPDYVSGDEAPPPPPPLPRTSSIGRQVSNRYIDYQPPNRLQLEPTITQINPITPPYTGIINPIYDIKMPRDKFSVKRSKSLGRSFSSKNLGIEINRYNITLGHKSGRRTNDVVTAITGMTGETGLETKGNFFQRYSTAEVVGDSYRVSRATID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR14</accession>
    <name>A0A835GR14_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR14"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55182" checksum="BA680F649FD3DC1B" modified="2021-09-29" version="1">MADKKKKIYTAKDTTTPRRPMILKSDRETAKDPAKEKQEKEKQPTIILKTREQSTPKEERPLSPKTIKTSTSEGDGPHPCKIAQNENKEKKATEQKPSPPLKYMTEPVKLLDENLELNHSALEFLHDSSTNYLVVGIIGTQGVGKSMILNLIGANAHDQSVCTQILNSHEMPQEKTFDSNEMGPLENQMESLDFREVPDVKGTEKTDNIFKFKMQDIEQIERGVHCTKGIDMYITKDRVILLDCQALWSPSLIEESNTAVTARSANVVTVDCLQIASYLMAICHVLIAVQDWFTDYNFLRYIQAAEMLKPSLSASNTAQSNQEGSESTGGGESHPHLLLLHNRCQLEDYTPESLRIMQDLYRKAFLKSNLQLNSGIYMYSDTNKNNLNVDSVCKGYSVQTCGTPINLFLLPEIYADFDNPEIYRGHPPFEQLANRLRWMILGVNRHQITNVPNLSEKGWFHYCSKAWETIRKCTFFMEYERFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR95</accession>
    <name>A0A835GR95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9421012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="495"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="603"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1209" mass="135052" checksum="71FE7393154617DD" modified="2021-09-29" version="1">MIKLLYGQPLEIFCVAENYTAENLEFHLGRRVIESEKVNATTRRLYITDLEKNVYTFYCRNNVTNKQCTSRVLVDDSPSNVTDFGCISNNLDELNCTWTSPEIYSITTYRLSFNIYGNSFEPCEAKRVGKLRYCSWSTTSQPRYKQMETHYYFNLSSCNYFGCIEQNFTIDHFSVVKPDAPEQLKVLKFETHNVLLQWKIPNNMYDFLPCAVVHRIEYQIAKIDNTAYFRSVDATMLPPKNKTYTFLLSNLPYAHMSYEVRIYIKSELATEDKFWSDFTYVLFTTASERPQRPPDTIAGAFVQSIYENKRVIYVYWKQLEEYEEAGANFTYKVVATTGSKNPQTLSPDKNKSLSYVELNGATLDAIDVTIWSTNAIGSSVNSSHLYIPSKYDTEVLSVSSFTKLAYENGTYKLSWVGVKEIDNYTLFWCQHNTSQICTGRMNFTVLDPKQSNHVIDLPRDSRYQFAISANSGSKTSGMTWASCDISKDGIPMYGFPVKVNHDAPGKSFVKITWTMSCTLQEGIIKGYLITYCPVLNTSNVCDTTYENKSTYYVSNPKQMEINITDLKPYTTYLFTLALNTTYGLKTIENASTGVTTIEDTPTSPRNVRISDVQSDSLIISWDPPLHKNGIIAKYVIEDGKGLKVDKMVDKMTEKDKNSTRIYMKLTGLQAYHNYTLTVSACNAAIRSCSKHSPDYGIFVRTRIGSPSMLKPPTIKNKPDSLMWEPPISPGGSVDLYQIRRVKDENTNRDEIINTTSLSYSLTHCEGVDESETYQVRAVNFDEDPYYGILADRPEVALPLKQNRKFLEYPGPWSPPASVACRSKEGLTMLVILITIFALIGIMYGSIKLYKKYRKMEDIKPVLPSGLGIPEKDISKYAFGGWNPTNKDDKPSSDEMLLLPNSRTTVSTPETKQNSENNCGSSDHTDSTALSDTSRGAIERQASTSDDGSDSSLHLEVEAVRTDDNIATQDEDSSNSETDNSRENSPYFSDKSFKKNPSGYVQPVAPVVNPVSGYVQSAPTPHTSPHAKPASQPTSSSYVMAALAPPIFTTGVAPPSVPSQPPASSGYVMAEDAQAKSMMNFPKLGPSPTKVFGSESLPIMPTLPQPVKSGADSSYIQLQSLDALPSHKQPARNTVPLKPPTSNGYVSPGDAVINKHLNNMLSGGQLEESAILDPTMSPDAYCRFSWSTDPANDNLHSLLADSHTLNLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRA4</accession>
    <name>A0A835GRA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_002404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9421723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19581" checksum="AFD41BFEEBF6DDAE" modified="2021-09-29" version="1">MGHSYEDNRCKCVCPSPAAVLNNTAGADRSPFMKSANVPPNKCNCESVILPRVADQIKGREQEFCPRCECKYENRNTTIIKVVVIIVIWVIMLLVVYMGFLICLDPLINKRAKASYQEHTNEDDESTLGGPSQQMGARGNVLNRVTHQQDKWKRQVREQRRNIYDRHTMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRK7</accession>
    <name>A0A835GRK7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRK7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="233" mass="26876" checksum="E19AAFC2A14A47E0" modified="2021-09-29" version="1">MEMMLDNLSFTTDTHQLALEFVRCTLMANGSVGWNVNATSLRALAGTDCPNTPASDSFIVAMNMIKMWSKVIRNGILQLDPRRQRRLCTRRSGKTLGVKLELQYKLNARLGSMFNTLSSLSKRRSFKYGLPFILFMVGGSFGLREWTQIRYQFSKVKGVSKEEAQKMGLNKDKDVTLEQTYEEIQKLDIDNWENKRGPRPWETIEEKKKLRVVGLLSMDMKVFLFSRDIDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRM8</accession>
    <name>A0A835GRM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000479</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9424340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1754" mass="197517" checksum="54E1C08D5BCAA878" modified="2021-09-29" version="1">MRTFTLPGRGDAVVELWRSKMEEGVLAPAHFLDHWRVTVPRIYSPQPNRTCLDWSFDEDLAAKLLIQPLEQFVWGNSDGSQPPLPRRSTLCGRVFKQGDPAYSCRECGMDNTCVLCVECFKVSAHRHHKYKMGQSSGGGCCDCGDTEAWKRDPFCELHAASENDNQEEATIKPEVVERMKIVASVCLTYCLRLLTHDHAPGLPNDLRLKDAERDLLQILDQPDCYCTVLYNDETHTFDQVITTLVRVTKCNQRDSLELVSLIDREGRALVKCNSFQVCDKLKTDIEICTAMFERFTSRHGPSLKVLVMHAHVIAHQTFAMKLLHWLQNFVSQEPSLRLAVSQVALGEEVWGASTSVGGGGGVACGVMQNDSRMWKAARTAWHRLLIATTLMDYSTKRAMAILFTKNYGSILKDFIKDDHDHSFSISSLSVQLYTTPTLAHHLIAKHDALFVVMNTFISECNRRCNPQTGRLEFDRTHIPMAFKRAQFILYDVKYLLSSVPTSFDDDLRKGFMHGMSLMLNLLVMMQGMDSVVRQVGQHMEYEPEWESAFNLHVKLAHSITLSLEWCAAEKTLATAVYRMALRKYSETYTPPPRVVRELGNQSASVIPYDVSTEPVSIHRPLSRYIAGLHLLLHAHGLSYHSREFDRQDKPKPTPVELIEPVLQTMAMIGQVHAGMWRRNGFALINQLYFYQNVKCRAEMLDRDVVMLQIGASLIESNEFIIHVLNKFNLLEWAAPDFEQRSLEDDTLRHTISMLEEFLGLLITIYGSRYVPGVGEVTNEDRTMKEIIQMLCVKPMPHSELNRCLPEDQLHETGLEAVIHKVADFIKPTSGNNRGVYKLKPHLYDEYDTFFYHYTREELSRSEEEQRNRRKAAGLPECCPPPMLPKLAPPFRLLANLLQCDAVHHVLKTVLERALDLRARSFSETQVHKALHLIGYALRDEESGHYEFVQFAEGCARTGLAALLQQLAASPRLDAHRHLARWLHHKIRSLLGQTDEHIGDGENMDTDQEEKPTNDEAAEAEKSRRAKLAAERRAKLMAQMKTQMNNFISKNATLFEETTTEVTAEEQELRPLYCGAALGVWGGGVPEPARVCIMCQEEARVDLKAEPLVLVAFVQQSSVLTRTRREQHEAWRAAWLPAGLGLQPHVSSCGHALHAACWRNYVDNVQDKENRRPYRGRQPAAFDVEKKEYLCPLCERLCNTALPLLPAPSIPVGTPPPLTEESYNESVSMILKLKHQVSSEALHICTEFCEEMHCQARARSVGAMSSDMEDGELADETEVYVSTHAENLLKPDFLVHFDAEIPPYNDMTKTLIEDFANILPISEYGGMVSSAALYRSTSYTILSTNAVLQAENRPLLGELPARHRDTLQALIRLAAALPSVWSSPKHLSHHALSTLNTLESTSPLSHEPFGTLVALVLTAPCLFCKAGGPARPSNLAKQITLQCLRATITRALLVTDLTTCRSEPMEGQEDFKNADLENLLPLIKELRNGILEDCLNPTEVWQLIQGQCHTFLRCCCLFYHFLSDISAPSELTVVGGDTWESLCGYLDMPTTFKELVDTPSARKKIMEWVGVSTEWFTGEIPPHVVTEPKEPPSLIPLPEDFSELMNLVSEFSCPNSEREDSKKPTMCLVCGQILCSQSYCCQADIPKWGRSGEMQRVGAVVAHCARCGGGAGLFLRVRDCELLLLAAPARGAKLPAPYLDSYGETDQGLRRGNPLQLCPSRYSALRMLWLSHGLHERIARALDTNVLVTTTWQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRS7</accession>
    <name>A0A835GRS7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRS7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="530" mass="58665" checksum="24E6CAB0444A5B4B" modified="2021-09-29" version="1">MSTAGTAEVVDPDSVQLVEVGIAEVVDWESAQPVELNLGQDMEQGFGQDRSQGCCGSGLGAFGLLAFSVFEEGSLASTGPFTSVFVITGSIVVASLSSTFGSTFSFVSVFELSTGFASVGLSLLRFATSLPLRTVGVPYLIRHKLNFINNVIGKDPLTPQSETMSPETRQSFGNTEDSVITHPGLCQHSGQPVELTNSGSLRLKTGEGGNSTFINHSDHPDSLTATFSTCKSSHKTGCSLSIQSEENYSGRRYKFVIMNIILSCAFILTITTQCYGVSRISVKHSNYTYNYGFQDQSGLAINRAEDGTWKVQSLSNPKPQYSYSSRTTKESFNSDPQRTDSYQRQYQDRMTTTPEQPTPSNRPRPPINNMDHTIQPGVPVRRLNNQPYYPPNLSTTEPSAHPVSGFPQEEGQRPQQGQRPKNRNTVFTMVDDNSNVLVYNSNGLPIYQNTHTYSRNPPYDSPPRPTYQPRPRPVYHPTPEYPRPDAHYPTYYDNNNGGVYVHQSVNTGGPFPNFVNNYIYDIRLEFLIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRU0</accession>
    <name>A0A835GRU0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_004104</name>
        <name evidence="7" type="ORF">HW555_000756</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRU0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9633390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="307" mass="34638" checksum="498411D26248D8FD" modified="2021-09-29" version="1">MSTIIKFDIKELKKLANDKNSCIIEKKVTQNLALQPWCLGNLKESIKNLLDYKIGKFDKEFNGILLSYKNLRILQNVGTIRNDNADIHFQVQADYFIFRPFVGATLTGVVNKKSTTHLGILVHRVFNVVIPRPTEEPGNMWVGSNIQEGQEVKFRIVVLDLFGALPYIRGQLDDRCVKLGPDGDDDEEVEKKPTSTINVSYVDFDKTKPYSQKQIGDGLPHSTSKNNTKLINSGKMQLKISSPGTVNESFNQSVNGKSGSTKAKNVESEISVTEKNKTKRQSKLIESEQKQFEAQLKPNKKHKRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRX5</accession>
    <name>A0A835GRX5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRX5"/>
    <dbReference type="OrthoDB" id="6084504at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="28612" checksum="E65B3964ACC5D2E5" modified="2021-09-29" version="1">MEQQKRKRGENWSCDEKEILRQLIAQSAHILEDKSTKSSVNLQKIKEWKNVQVKFNELTGKFRSGGELKLAWKRMKLSAKSNLSMHRREQRMTGGGEKPPSPSPEDLAVMAIAPHDFVIETNDYDSDALDPVPVPTINAAGIDSKPGPSFETVSFHIETCEDRPEKDFVSLQDTTNSEACVGEQATIKKKKSLQNRTDEMRQTIVESNAAFKKRQLEMMEEEHAYNVEIAKLKIQKLKLEISLLENKTRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSG0</accession>
    <name>A0A835GSG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="324" mass="36954" checksum="7A3E4673FAB8A316" modified="2021-09-29" version="1">MSLRFLRKIRVYFKTKPPKQNWSETSGHSYCTIEGEKMDAIKAMKRLGYTFNSEGQLRKVGVDGQITEEPFQFNVSNQHQECQAHYEELGSAVTEYVYHLMETERNLTRLPVPKDSNKGTFIFVSKDYDQKDVLLILIHGSGAVRAGQWARSLIINDNLDMGTQLPYIKRAQEKGYGVMVLNPNDNFLSNGQKIPHSNSGEEHTNYVWNNYVKNTKATKIAIVAHSYGGVLTVTLADQLKSEFEKRVKAIAFTDSVHVYSNIEITKYMKEAARNWISSQSPLDTPMNTPDYDIPRVSAGHQKHEMTSYSCMESVFKFIDEKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSG8</accession>
    <name>A0A835GSG8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSG8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39141" checksum="74C761C37A034F95" modified="2021-09-29" version="1" fragment="single">GERNLVLKVLEFFENEKRNKQFCLPVDQAVKRTCMATGISKTTLMRIKNEAKRLQNTSPTPGTSASSTVTNSKNVKIKDIFYPKNPIFELGQQGTYLRRLKQDDDLGAGKKPVIYIDETWIHSHYTVSKCWQNNTDASIKKNHNPGQRWIVVHGGGEDGFVNGAELIYKCKSNSGDYHHEMNTANFKKWILEKLIPNLPLNSIVVLDNAPYHSTQIEKPPTGVATKGAIRQWLLDHNITFDERMTKSEMYHLLHINKPPKKYLIDELFKEHGHEVVRRPPYIISESDWKKEVNHVDRLRQKYWDDDLLQETNESQLIVNLSDTSSSSDYSETEDEEQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTK6</accession>
    <name>A0A835GTK6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTK6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="126" mass="13923" checksum="B34BA93359A4F4FD" modified="2021-09-29" version="1">MSAQAVTQITLPDQHHTFLTNQLIGKSLSIPKSFLDRLESCHVVFPNGMVYEAFPNNRLPSGPITFLHAAQPFTSCAIGFLDADVSLSGTYELMSLINHSADNSFSLTRQSFHLTLIEIDPWKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU17</accession>
    <name>A0A835GU17_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU17"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF177">
        <property type="entry name" value="ANNEXIN B10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="329" mass="37230" checksum="893E7A17E285C572" modified="2021-09-29" version="1">MVYQREPTVVGVPNFNATEDAAALRAAMKGFGTDEQAIIDILTTRSNAQRQAIAKAFTHEYGKDIIEDLKSELGGHFEDVIVALMMPPEEYLCKELHKCMEGMGTDEDTLVEILCTRTKPEIAAIVQAYERMYDRPLAEHMCSETSGDFRRLLTLIVTSSTRQGARDEEVGVDPEKAREDAQALFDAGEAKWGTDEEVFNRILAHESFAQLSQIFEEYKNISGRTIEQAIKAEIGGELKDALSAIVECVESAAAWFATRLRKAMQGLGTDDRTLIRIIVSRSEIDLGAIKAEYERLYDKTLESEIRIILRYYESEYWIVLKTIEYLFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU60</accession>
    <name>A0A835GU60_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU60"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="157" mass="18355" checksum="08107BE995478336" modified="2021-09-29" version="1">MRCGVLKAYREPYKTFTDLDMLETSRRSNRRRYRRNPFESSEEDFRYKYRFTKRFGAKIVDILREDLCHDPRGCPLSPELQVVCALRNWARHEIQDDTADLHGVSQPVVSKSCKMVIKICTKKGKCSIQENVSPFFTKGLFINNTETNGTLLQIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUC0</accession>
    <name>A0A835GUC0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Yellow-d</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUC0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF7">
        <property type="entry name" value="GH10609P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="54608" checksum="C51048B1B5A9506E" modified="2021-09-29" version="1">MVTMVSFFEREEYCGVILSQYDPHLLDTFKLEMSQGIERFFLLSYCLACCWPGLGAKNDLRVVRQWAELDFVFPSEEAKQIAIQKRYYVPGNSVPIDVDVHHRQGPYPSRIFVTNPRFDEGRPITLGTVDDTGRIVAYPDYSWHDNQGSNCGGMTSVFRVAIDECQRLWVMDAGKIGDKQVCPPQLLAFDLATDRLIYRHVVNSSNYLEQSLYVTPIVDVRPRGPGDCANTYVYVADVSAYSILVVDVMRDQSWRTTHRLFYPFPSRGTFTIDGESFDLMDGILGMALSPYHHGRDRFLYFHSLAATTENVVNTRILRNNSYLQDANIDPDAIYVFPKERPSQSAAEAIDQNGVMYFGLMDPPSIQCWNTATEFSPRNFHTVAANQETLQFASGVKIVKNAKEEQELWVLTSSFQRVMTGSLSPDRMNFRIHAEKIPVILANSPCKNSPNGQKPGYHVNLVDRSSDGHKYRPTRYGSASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUY2</accession>
    <name>A0A835GUY2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUY2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41048" checksum="7607A4EDBC1DE2AC" modified="2021-09-29" version="1">MITSTENISCVNELTRSNIRLTGFQKQKTWKEKPKKIIKYAKNILRETTVEPCLFIYMLCTAISSLAVMNMHLDKACRVNLDYGTDICDRISTRNTSGLDKEEKEIQSLVSAVVAWKFPLQTAIPAAMVLFVGAWSDKYKKRKICILFPFIGEIICNIGLLFATYFFKELSLTATALIEALPAAFTGGYIIIFMGMFSFMADRTTIENRTFRLGLVTICVTAGTPTGTALSGILLRAMGYYGVFSLLLVLYTISFVYGLFRLEDIVPPDEEKTFNDIEKSKRRNLLKEVLELVGNTVMVAVRPRALGGRAQIFCVLLLYLLMVGPLYGDSQVAYLYVIRKFGFTEVEYSVYGTINIVLGIFGKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVD1</accession>
    <name>A0A835GVD1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVD1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032627573" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7004" checksum="0B67727841B070D5" modified="2021-09-29" version="1">MSKFTIVLLLIALVTMTLARPQDDGTKVDIVDGDRQVDFVDSDPQQVHIVDPVDLVNPRNGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVW4</accession>
    <name>A0A835GVW4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVW4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25527" checksum="7553A2DFA03506E1" modified="2021-09-29" version="1" fragment="single">IMEPPQLLEGLVKAIQDAITSNRRYDDIALPVFDPEKNENGAEGWCRSIEKLGAEFKWTSIQQAATADWPSVLWKVQLSLNTTVQQSTGFSPIRLLIGRNSNIPSIQARLDDVIRDDNAIIDVTADRQLAHQRLKIVADKFKERFDRTRRDNIDYSVGDTVYVNQDHRRHDKLKEKFKGPYEIMNILDNDRFSLRGIGNLRNIIVAKDKIRLWPGEWTEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWE5</accession>
    <name>A0A835GWE5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWE5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="39740" checksum="10A06EACAFAF09DA" modified="2021-09-29" version="1" fragment="single">FEMDMFEDFDISQDDLSQLDQIEINLLNNSFHISSDEEDNIHPVSRNRRRIMVIDSEESESEERPVPATSGQTTPRKRTWTLPTGNQRSIIPFTENPGLPTYLRLAMSKKSPIDFYSLLVPDDVFGQIVEDTNQFAINTITKRNASKAARIRNWSPTNVHEMKSFFALIMFMGLVKLPKLSDYWSKDEITGHRFASTIIAKGAVDLSDQMAAYSSPLRKSVKWYKKVGINLLLNTAVVNALILYQIVTGTKMQIVEFRKQLVKGLLMRSEETSTDAVTRPKRMRHKLARKDGSSKNNRRTCQQCYKENTQVMGRKLAKNKTKKVVTFCDTCPNKPFLCFDCFHKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYK5</accession>
    <name>A0A835KYK5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000370">
        <property type="protein sequence ID" value="KAF9408651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="44"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="692" mass="78246" checksum="3CF33FC2EA378DF6" modified="2021-09-29" version="1">MLQHFASITPGGRVYPQATNKTQADTFLDSLAHKLKLEKWEKDEVACLESVLNVLENVKNHTLWATWIWNANSIPSGNLYGSFRHYASYDQCLKPPWLHTHPKLKTKYCFTDFQLSDDNHHSVTPSGMPVNQIMWGLCIPAACSPPAVSKLTRVVYEAATFSSIASDVTVKHCQEAGETLPYSTGFYIFIILILSLIVTAVASTLYRMHESSGDESADSLMTIITKSFCMIKNQEDLIKVNKDEIRVMNGMKFITAAIIISIHVVFYMSISGIGNLMDVDAFLEGIGGYLLHFDLFVDTFFTISGLLHIKGLLGRRQNLFNVLCKRYIRLIGPFALIVFYLISVSKHFSYSPVWLGLEETDVCEKNWLKSLLMMNSDCHDVTWYLACDYQLAILGTFLFYLYQKNRNFGFASYTIVAVLSMVIPGVLTYLFTLPGVLFVDYGKYVIKYRETWEISLLYTPSYSRASPYLVGVAMGYFMYLYNPANYRKSVSKNWSIVGIAVSFIMMAATMSLGYILRQRGLDPIDAVVAAATNRIFWAAAICCIIGMCEYGTVPIVYKVLSWPSFTPLSRLSYGIYMTHSLVIQRYKFAQRSPHVFDIFCLIYDLVGTLGISIGLSYAMWLFVEAPLINITNQLFFNKTNGKRADRSRVENEIRNQNGKPKSEISANGVQPDKSWSENGIRHQNGITKNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ33</accession>
    <name>A0A835KZ33_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000553">
        <property type="protein sequence ID" value="KAF9406748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ33"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="262" mass="28687" checksum="C6EAFCA37C04E265" modified="2021-09-29" version="1">MASKVAVVTGANKGIGFAIVRGLCKRFDGVVYLTSRNVERGKKAVADLEKEDKTSLEVFRDFIKNKYGGIDILVNNAAIAFKHNATEPVAVQAKETLFVNYFSLVSTCDILFPILKNGARVINLSSSCGQLGLIPSKELRERLKDEKLTVPELSDLMQQYVNAAQQGTQAAAWGNSSYVVSKVGVSALTNIQQRMLDSRDIKVNAVHPGYVDTDMTSHRGPLTIDQGAEAPLYLALDAPDSVRGKFVWHTTKIVDWDSENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ50</accession>
    <name>A0A835KZ50_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000311">
        <property type="protein sequence ID" value="KAF9409531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ50"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9409531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="374" mass="42032" checksum="29D33C3F5C2EE775" modified="2021-09-29" version="1" fragment="single">LINSTVKMEAGEWRRNIISQLQARNKYETAAFQDIIAFQSRLFDNVNTLKNENLQLTLLNERIRFTGAESVSGTGNASNERIQALEQKILVQQEELTSMHRRRGENAQQIMSLNEKVHDLEKQLQAKDIVISENTAVIASLRAEIQMYETNMAELQGLNQVLRDEHQALQIAFAAIEEKLRKAQDENRSLVERLIKYKAKDADKMNEENEHFLKSSNPTAFFINTFGRVSFGKKSDKVRKELEEAARESGSRSSGSGSSEDKILDSMPYFATVLPNKVALRFDAHDGEVNAVKWSPTDRIVATGGADRKVKLWDVTKCMVETRGTLVGSNAGVMSVDFDSTGAYIVGASNDFASRVWTVADQRLRTKLTMSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ65</accession>
    <name>A0A835KZ65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peroxisome biogenesis factor 2</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_012295</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="JACKWZ010000434">
        <property type="protein sequence ID" value="KAF9407798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16526">
        <property type="entry name" value="RING-HC_PEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045859">
        <property type="entry name" value="RING-HC_PEX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9407798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="280" mass="32836" checksum="A04CE1C68B8A2CE3" modified="2021-09-29" version="1">MSVNYIPRVTQLDAVQLDSQLEELFKQLLFEVTKYIEPRYIQPILPELELLIRSWIFKYSVYDHKSTFGQQMLSLNYKTDYFTRSKLFWYFGYTVGLKYLRERAIYSFTSNTKIQNIVNKLETFQLIGDILNFCRFIQTGKYPQLIDYILGLQLSAKALTREDLTDLSWTRELLWHNFIELLGTTISLINIFGLRSKLSGMLKYVWWRQHVKSSGTMTMPTMTLQTVCACCESPPVLPHIMGCSHIFCYYCIVANKTADSDFACPKCYYNGKEVMKFVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L075</accession>
    <name>A0A835L075_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L075"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF38">
        <property type="entry name" value="SAC3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="30"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="43639" checksum="AB029ED95D328E52" modified="2021-09-29" version="1">MSSYFEFFCQNLACKSTQNADRILGTCYSMCPEDEVKLREAERLVHVLEVWGSERKLVKSYSRSAADSNMAVPHLLRPYSVLVNTVQYLLLDITRRVDVPESVMYDFVNDRLRAVRQDITIQRLHPTQCVDLLEPMIRFYVYYGYVLSGHPLKDYDPVLNKKYLLECLKWYLSCCDIIAKEEGHIDKLSDFFSSLDLNTRGKTKTKLVNDQVLLESLYILCNPDDLHPLYRYLKMAKDLKGQEKLKLSYEIAIANLQGNYVKVCRLSEKLCPLLYCAISTYLPILQRRALNVMCSAYNNKRLTVPSAALVRWLGFSTDRDASTACSHYGLQVNDNMVRFDKTDFKTDARLHIPVIRNIRKKFEVSLIDIFTYETCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0B3</accession>
    <name>A0A835L0B3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000528">
        <property type="protein sequence ID" value="KAF9406932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0B3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="201" mass="22153" checksum="E46AD3191C4B3A98" modified="2021-09-29" version="1">MTRKHLVFSTDPESVKDEFAFDNPGFRQDERTAWQHEAPTLPLSGKPQGLHVEFTKPEHSKDDSYLQDNGNTKRMHSFLPDDVTLNDVNIDLTVKRARIRRVKLWARDFTGLGFRCGGGARDGVHVHSVLRSGPAAAAKLQPGDKIKSIKIEFTGTPLEDAVSILSLASPYPVELEVVEGGRSSGAGRAVHHPLLKRAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1R8</accession>
    <name>A0A835L1R8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_011679</name>
        <name evidence="9" type="ORF">HW555_010232</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000245">
        <property type="protein sequence ID" value="KAF9410807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000210">
        <property type="protein sequence ID" value="KAH9641929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1R8"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13226">
        <property type="entry name" value="PH-GRAM-like_Eap45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000416">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9641929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="402" mass="44617" checksum="A373EE0FCB6E3923" modified="2021-09-29" version="1">MDRFEYIEARLFEGENYLKRDKNVKIYDGDDKTHFTDGEVVLTTHRILWGKPGDIPKGLVCLSLHLYYVFCIEEESGGVFGLGGPKRIILHLGPALPGKRPGPAVASPFHFVKFSFKDGIDQVFYKALTDAVAAKAWERPATISSPTSVTSSNASIKPAVTPVNSKIRSGIVGIERSIEEQHRATDESISVAFQDLKKLMEKAKDMVAISKNISTKIRDKQGDISEDDTVRFKAYLMSLGIDDPVTRDAFRSDSDYYLGLSQQISDMMVAVLMDCGGIMSLADVWCRVNRARGLELISPEDLLNACKLLQTIGAPMTLRKFPSGACVLQLNSQRDEEVAKTTCELLEENGYLTPVKLSQIANVSVLLARERLFTTERLGMACRDESIEGLAFYPNLFLREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L356</accession>
    <name>A0A835L356_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000176">
        <property type="protein sequence ID" value="KAF9412853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L356"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="834" mass="96126" checksum="7339490A7D252577" modified="2021-09-29" version="1" fragment="single">LLKNSGFCDYLESEANFHKPILERSNIVNKGVWVRNKDKENLFEKNRIGDFIFRENSLDVDNLLQNNFDAFGANYMQDSPFVSAYVKRNKRQTRHIRQQRPRKSIIRSCIGKGCKMSLEVKDPAPEIIKTKLNELTKRTTSVFNDYPYEVAILLNNKSDSNTEKINTPSVKKENSKSNSYNFTKNYGIPHTVGFSVETENDTATVRNTTSPKRSMKYDFETEIIKKFEFTEDINKTHGSMHNDSKITDRNIFDKESVWHQNAPIPDVNVYKVVPKEPQKSKPVTERGLIKVISMLTKTFKKIMKQHNEIKDIHSRISDINEDFIKNAATVTGKFQDFDLKYLYLLKFHEKLKAFDAKLASKQEYFKNKEREMARNFKEFENQQKKFLQQQRQFYNIQKLMLAQNEKINLKQNLIAKTQSEISHRQNNFARILKKAKQLYVESRNPSITKLSSSLTKLNNHNQKPEPITHTSTVTPSTESIKINLFSIPTSNKLQNQDDLIMKEKDEQSIDDLVYKYYFNNTFIDNLMKNNILANVMGVPENSAHQRNVKNKRNELQSTVMLPVFETNNTETYDNKNRERRWINHHSRHKARRRDRGKGALAPIINATDAKILRKNVVNNAPLAAEAPVLKETKDIKIKNDPFLTMATNFCNEIRQNLNPQMLRWCVEKALRRLQFLDMKTPSPAEAPKTIPAAKPLSMPAVSKLNQPVTSFTESSKLSGVSEVASAFTTDRVETKQSTVSTSEVPSKMTVSPLTQSTSRMITTAANKENTKSHILGDINHFPDNEELEWNLKQFVDSESQGIDDIIPGLDSNSKVDLDPLAFDLQAQRRALVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L359</accession>
    <name>A0A835L359_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9413985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L359"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="413"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="489"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="543"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="618" mass="71721" checksum="2F2009F0900C1C78" modified="2021-09-29" version="1">MIGAYRYNMDTSSKGPKVRWYCTRYAYGLPVFSMTKGGNPVIMIGTYRYNRTNGCNGAKVRWYCNSLHLQPFTEAIFTTTKYGNPVIIFGPYRYNQASAIVSDRSLRPLFSKTKRVPVKWMMKKNRKELAMVNGFTFYCHKNNAKTKIWTCTSGWHCKARLITSSDSDPEKRSVITAKLEHNHPPPTYIITDGFYADIGLPRYFSWCERRKLCPSRLSETIILVKFVKRVNGKEVALVNGYTYYCRKQSLKKSTKIWNCTYGGTCHARMEITNHVKPSRRIVLSAKLEHKHEPSEYCISNGFLLYWVAKDNGKVLAVLNGYTFYLRRFHPVKSTWSCTQAGKCRARLMITSEKNVTDRVVVSARLDHNHTPPSFSISNELNIQWVKKINGKELAIVGGYTFYCHKQNPIKMQFVKKQDGKEIAIFNHYTFYCRQQTLKTASWVCTNSHRCKARIVMTNALEPWSRVMKSAKLHHTHPPPTFVIHDVRWVKKRDGKELVIFNQYTFYSHMKSMTTINWSCTSAGCKSRLITTNEDMPSQLQWIKKPNGKELIIVNQYTFYIQRKCTNTINWGCTYRGCKSRLVTTNEDKPLERQVLSFKETHAHPPPNYAIARGFYVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L394</accession>
    <name>A0A835L394_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000106">
        <property type="protein sequence ID" value="KAF9415642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L394"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22755" checksum="3EB52CA4F2E0B550" modified="2021-09-29" version="1">MEPNMAAERASTSFDFPPPLKLESMSSPDAISVCQCLLSGDDSTKEIEVPQRKQRIFSVVSRTENYLRERRIPELVRFLLAKIMCSNARNPVTYLQDLLDDCMIFRAGIGPAPVLFEQRHLEAVVKSFDPSGRGWVSTGQVRRAYITLGLPPPENIEERISTAELLEGLKETQERELLSLLCAGIETYEHKQDKNRQESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L454</accession>
    <name>A0A835L454_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000109">
        <property type="protein sequence ID" value="KAF9415521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L454"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="575" mass="63651" checksum="C82E6B019ED18655" modified="2021-09-29" version="1">MYSVAVINIINLIQTGLSYLALAQFSAYLWPQDAVVQDGATFDYIIVGAGTAGNVLANRLTEDNHVNVLLIEAGGDAPVDVVVPGCTLFLKQSNYDWNYTTEDYTIPKKCHQKTYHEPSSGKMLGGTSSLNYMLYSRGHPTDYDNWATITNDETWKWENVLPYFKKSERIEDPDFLLTGDMTNHGSKGFVGLTKESRTQTENILKSFNELGHDVIDDSTAGLGYSNAWIYIGKGGRQTSALTYLTPIKDRENLHLLKKAHVTKIIFDKNKNADGVEVILDDGKTIHIKAAKEVILSAGTFGSAKILLLSGIGPKEELKSKNIDCISDLPVGKNLQDHTGVVLMHSMEKAERLITNPNKHPSAPVVGYATLDKSHKHADYQTMSFYAHSRLVLYFCSFAYKLSYEICDKIFTSSLGKYNLFTEIVNLNPKSKGEVTLRSSHPMDPPIIKTGYLADEDDIDHLVKFTKLVLPIVNTTYFKSIGAETLDPTLDNCSDFEKGTDDYWKCYASCMFSGLSNYVGTCAMGSVVDGRLKVLGVQRLRVVDASVMPVITRGNTAGPTTMIAEKAADFIKEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4F7</accession>
    <name>A0A835L4F7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2239" mass="262963" checksum="A68ABBF440D40A2A" modified="2021-09-29" version="1">MICYLTTMPPLTLEGETLGEKRRHFNKLVADAVASKHYELTPIDYTDSDIDNLLKIEIACKTRNVDYVIEVMKSKDMLYASTAIKKSTWLITDPQYANIINPEYLHTQLKPYMTTKAFNKLMLHIRLNLKDEPRVETFYEHLKQTGKSEKWLQNCSIPFIENAISFSVPVWLYRRLLKKTPLLLTFDIDASRAERQAAYLSILKSRTADVLDILEDTSTRLFIVEMGKKRTEFVMKKCPKSVLENIERYQRTINMSVVARYINKNEIKAFLCKNASPIEFYQDYKALTSFVKNMPEKERVEFIQKSFIDRTEMLFDKNEMNCIDVSHQSYQWYEFYPFEIALPKINNLIRKESSPSKRCAILSILISSAKTNTKHIKSLLTYVTEKHMNIPVKFKMNFVKNLLSNVPSHELDEATWNILDQIFHSMDVYAGTGDDAQWCREYIIVRKVLNDEPMPEGIEQKCTFISYKNVMKSLNTEQKSKFFTYLLNRMMAKCEGFANESDFLETVHKIEKVLILIKDFNKNLNDYPFVLEKIQNLYKIKKANNWTTDMSCLYNVNKSWRKYMFEDSLSLCLCEETCLNALKHKPQLLTRHDNQIHALRTNDAVSLRHVLAKLRVYWPDTLARHWTESYMQHLNDPTGHKAIIKGLFMLLSQDQAIELAKRYVPKNFKINWCLTDHTEISIRINIAKHLHLARPLVPLETVLWYANGDYVQYAMQSHIAIWSALGEIDSRENLSKLYDAPISLLKFVLDQAFFKLPTSEVIDLYWKIWKSTKNSTIQAIIFDHTAYEMQKYYENETIQNDLWKLTKHGEATDINKQLTNFDVIPYEKRSEYYMKISRYLVSLPISEKYLNDLLFFGFLHMESLDEDFIVNVLLSPVEIRFFSANTSIVDCFAHFLLRSESEENQLERFKLMEPALDKAFHNWHNIRSCKENFEAFLNTATRTLATDYAKTIPIPAKLFAEIQSKMENGLSVSGNYELLTSWKLITAYVKILKLNEQCPERENEDQYNDWDLSLSFGPIILQYLKEDVGEYGDNVKTVILRQVLYDDDFVPALLVVSKIIPKHPDAETKCARSEILQKLKSNASMYNLTSIFVKGETLGEKRRHFNKLVADAVASKHYELTPIDYKGSDIHNLLKIEIACKTRNVDYVIEVIKSKDMLYASTAIKKSTWLITDPQYANIVNPEYLHTQLKPYMTTKAFNKLMLHVRLNLKDERRVETFYEYFKETDTACKWLHNCSFPFIENVIKNERLVPKWLFKRLCKRSSRFLIYNARVEMYPHERGQSVLFMLKSQTESVLNIMEGYKIGFIPKMGKKRTEFLLKKCPHRILDNIQKYHQSLDANVLVKYIKYNKDIKGFLYQHATTMRYNENFKTLGLFIKNMEEAERIEFVKASFIDKTKPLFHEDDFEYFGLGPVIHSYEWYEFFPFEIAFTKIKKFLRKQESPSERCAMLSVLVNTAKTNAEHIKTLLSYVIEKHVNDPFKFKIKFVIHLLSNVSPHKLDMATWNILDQLFHSMDVYTETENDVQLCRESIILRKVLNDEPVPEIIEQKCTFAFINKIGSSLNKKQKNKLFIYALNYLMSKIQINKIVNKSDADESLRMLQDVLILLKDWNRQLFEYPLIYGIIQRLIEIKEGKGLSVDLSCFYNVNKSWRKDMFEESLSLSLCEETCLNVLKHKPQLLTRHDKQIHTLRTNDAVSLRRVLAKLRVYWPDTLAQHWREAYMESIHNISEQKAAIKGLFQLSPLEHVIEMAKSHVPFDSKINWSDTNQAEISLKKNIARHLHLTRPRVPFDTVLWYAKGDYLQYAVPPLSAILYNVSKVESREYLPKLLNAPVSLQKLGIRLVYTKFEAIEVKYIFSDIWKSTKNATVRAIIFENIFNQLCGSKNLNTENELWELLSMFMQEVNLQDSTRLYKILSNIKSVPINVRGKYYIKSYEIFKSLPKSHVCVRYLNNVIAYAAYIMELLDEDFVANKLLSPVESKFCTHNGHTIFMYLNVLTCFLLCSKSEEIHVLRFRKIERALEEVFKRWHDIRSGDFYVKNNFNRFLKSLVKNFQDYFIHNKIPIPGKLFELIQRKMQKELQLVENYVLFTSWALVTEYVKCMNEHSSNILNIIAASTSRNAWKDINLEVCEGHTLGEKIINYLRKDTEKYSSAIHDLFADALSQMFLMLNITDDSVLETLSHMLYDQEFIPSYLVVCKCIPKFCCGESKLKRSEIRNQMKSHPSALVRMQYHRYFYIIPEDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5S7</accession>
    <name>A0A835L5S7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000253">
        <property type="protein sequence ID" value="KAF9410654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5S7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032823322" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="7895" checksum="F862C1578441A56B" modified="2021-09-29" version="1">MGILTAVCMMSLVTSAPGRSTTAAAGPLSELHTTLSCTPGTEQITRSISSGATCNHISNLGQYEVAAARHNHNNPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L667</accession>
    <name>A0A835L667_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L667"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34969" checksum="C20A102D4F80DDE0" modified="2021-09-29" version="1">MLCKQSEIKKRRARRQRRWWMKKIHHNRTRQFIEEKFNELLYEPSGEFDNFCRMSYSDFEFLLQKISPMISKHDTDFREAIPAKFRLAITLRFLASGDSYKSLHYLFKVSVPMISIIIREVCRALNEILKDLVKSSFDVYDSSGNMVTPGSWRRDNDEYNALQNLPQIPRRSPVNAREQACTRREITMATKRGPTCKCIASACRKRPLICVKKPTLDWIGSKQAQAHASQAKRPFYMLAIVDPCQGLASVYSVWCPGSRQFVTEAVLVDGILIGVLMENAVSQLYLSAESASVSQQPFLVISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L668</accession>
    <name>A0A835L668_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L668"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53086" checksum="10DBCC17ED2DCE8A" modified="2021-09-29" version="1">MDDFRNKMKTKKKTENKGNRREERKKCDLENLKKALHAVKSGMSKKQAAREYQVPRSTIQFRLNNPDKINPRPGLTTVLTDEEENVLVNWIIQSSKKGFPRRKEDIQYSVSDFLKKNNRPNPFKNDVPGEKWLKLFLKRHPEVAVRTPESVTAASSVVSENDIKAWCHGIQTYLEDNTMFDILSDPSRVFNGDETNFLLALPASIETDIEPRAISNNESLESPLVQEHLDIENMDVVFADNVEENNEISNIPYSHEIEIQNTSEPNLPVVSVISEQHLTLPADKIASTSLPKTPIKLNLTPVQLNDILILPKTPQRKGTKNSEKIPFVLTSEEWQRINTEKKKAKELKEEGIKKRKLEREQKKLQKDQTQRKGKGKGKKTGGNIQNVKKIIMSKEFYSPPPDVNDKENAAQSIQNRAEFDLFDSPIEKQEDYSFPSTSREIVKKSFTASEIFRMLTDSDDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6F2</accession>
    <name>A0A835L6F2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6F2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="110"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="282" mass="32922" checksum="42AE1855ED5D82CA" modified="2021-09-29" version="1">MDIDMIDLMDLEDLDMLETSRRSNRRRYRRNPFESSEEDFKYKYRFTKRFGAKIVDILREDLCHDPRGCPLSPELQVVCALRNWARHEIQDDTADLHGVSQPVVSKSCKMVVCDADLKIMDIVTRWRGSVHDSRIFRECRLKQRFEAGAFSGILLGDSGYPCTPYLFTPLLNPTTPQEERYNRSHIRTRNTVERCFGLLKQRFRCLLRGMFGDIETAKKTIVACAVLHNIAIDMREDLFPGEEDNIEPSIQFAPSETVQQGYFPSSVRGNIRRRQFIETHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6M3</accession>
    <name>A0A835L6M3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6M3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZAD" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="86" mass="9997" checksum="50A2F6AB376DF5DD" modified="2021-09-29" version="1" fragment="single">NELLMCCCCNEHVCVKSLWAEYVWMGIPEVYGDMLRDCFNITWVQSNSSNDQICEICITQLRNATHFKQKVLQCQAGLRKQVLSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L720</accession>
    <name>A0A835L720_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L720"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="531" mass="58718" checksum="588C77E1B81E17CA" modified="2021-09-29" version="1">MAKPLQKERENRSAEKKDVVFHPFTISPESAHTSILLLDAVEPEIICQTLRAITKFSAQEMSNREILFDLDAISHILPHVEHLELNIRRFALKALAQLCQLPRGPEQVLKDPQNLRKIASLLVKGRYVRGARRRPPRAFGGCWSLVDTSGGKSSRWTGAPWVGETVPMVLIERKGVLSDSDSASSRMSVASAVSGKRLRKRPREGVDSGSESALSDTAVPAPKVGTKKGGRGRPTTTGKYVGIGLSRREAAAAIKAAAVAEKLEEDERQIAALTKRVTKGRVARLSESSSVVTDVGVEAEELPASDLNQRMVDAVAAIRRVSKVSKGLSGCSQKALKEATASIMESAQVLLTRSTTEETALLRAQNKKLAAQLAELRKEHEDFKEEMANFRREQLKREVGLPHITPQLQPQATSETSKQQPSQEMELTRLIRQEMASFNARFSVLEGKILRPPLAADQRSTQAPTYAAQVAAPVPPNRHKRLLPHKTRAQLLLLERERSSNKKRLNWLKKQLSLLSQPYANPLSYPRRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L730</accession>
    <name>A0A835L730_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_003410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L730"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000033">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9420349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="398" mass="44112" checksum="54BE60625E1F8263" modified="2021-09-29" version="1">MQNFMVDEQGSLKRKPGFATLSIHAGLNPDQWNGAIVPPIVLTAMYKQPSNGILGYTYSRTANPMRDTLEQCLAALEGGKYAFTFASGHGVITSVLALLNRGDHIISMDNVYGGTGQVMRENLPRLGIDLTFTDVRNERNLENAIQDNTKIVWLETPTNPNCRVIDIAATVQIVRKRNESIIVVVDNTFLTCYLQRPLDFGADIVVYSLTKYMNGHSDVVMGAAVVNKQEIADNLRYVQESYGSVPSPFDCYLVNRSLKTLSLRMERHKATALVVAEWLEKHPNVIEVNHPGLKSHKGHEIFKKQTSGHSGIFSFKHSGGLTESRKLLTCFKVFLVAESLGGYESLVEIPSVMTHKTVPQLQKTKLGITDAMIRISIGLEDAEDLIADLGNAFKKTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7A6</accession>
    <name>A0A835L7A6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_018052</name>
        <name evidence="7" type="ORF">HW555_005606</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000001">
        <property type="protein sequence ID" value="KAH9646048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7A6"/>
    <dbReference type="SMR" id="A0A835L7A6"/>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20819">
        <property type="entry name" value="C1_DEF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047983">
        <property type="entry name" value="DEF8_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9646048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="441" mass="50721" checksum="BB97B0E878A9FE3C" modified="2021-09-29" version="1">MAAAIANDSPKYRNSLICCSPSVEATSRTSTSSTSGNVSLDEGYDSNCIPKSIANKKLKIHSSATKEEIEKAIIQCKELVLNTAQCSDERKWLVRYLVELRLRLEDIKENNGQARLRVSIKGHHFEQQTNPSNRKQYCDHCSGVIWSIVQGSYICNDCGYLCHYKCVDHICRVCAHVVMTEKGSFEMSICPEKGLAAQDYKCAECQTALTFKDMWNEPRLCDYTGLYFCATCHWNDLSAVPARVIHNWDWEKRYVSRIAYQMLNLSWSRPYIDIERINPRLFNFIAELEWVHKMRKDLEWMRRYLCACAEGTNLLSPLFVQLGDVNKKYSMSHLQAINDGSLETQLTELTEVCRSHITSCDLCSGKGYLCEVCKNNEVLYPFDSGALMCDKCNSMYHRGCWLRKGQKCLKCLRLEERKKTVDEVQTDITDTLQYDIDKFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z2</accession>
    <name>A0A835L7Z2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heme transporter hrg1-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9423009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026218">
        <property type="entry name" value="HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525:SF1">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16954">
        <property type="entry name" value="HRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02095">
        <property type="entry name" value="TRNSPORTRHRG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17277" checksum="2AF85B3B8E5F1537" modified="2021-09-29" version="1">MLRVKIHIAISAIGAVLGLSAFICFCLVYANIEAGMWALLSGTHASLALMLHCHYLKESLHVNFSRKALQYIGDFGIVGFVSGLALTFFYLFLEIYYKADVLPIKSSIVIRLVWSFMMMKWGLMLYLVTKKYLRTYNDHQLFSENPHIEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8M2</accession>
    <name>A0A835L8M2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8M2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000038">
        <property type="entry name" value="Dissatisfaction, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="104"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="365" mass="39553" checksum="FA53061F64081AE3" modified="2021-09-29" version="1">MIGQRARCAVQHERGPRKPKLQAGAMGALGPPPMNHAHKPHALKLSPPSPYTPLPQTFNFQFNISGMSEPAPLSTASSAGSSGAGGGAGAPSPLPLVPEPFLAPPPPGLLHILMSSDKCQELMWSAKQLQLQGDPTLLRPPPSAFGAPLAPTWELLQETSARLLFMAVRWVRCLAPFQALAASDQLVLLRAAWKDLFLLHLAQWSAPWDLAPLLAAPAARARLPPDPLADLELNTLQEILCRFRQIAPDGSECGCMKAIVLFSPDTPGLSETQPVEMLQDQAQCILADYVRTRYTRQPTRFGRLLLLLPSLRAVRARSIELLLFRDTVGDVSVATLLHDMYRMQPAPAPAFHPPPPPTSEHCSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Y8</accession>
    <name>A0A835L8Y8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Y8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000179">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032344427" description="Partial AB-hydrolase lipase domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="449" mass="50061" checksum="76D92E3FC02F2598" modified="2021-09-29" version="1">MAVLKLFACVLLTIVATNASYSVYQTIEKITADGFEAEAHKVTTSDGYILEMHRIPHGRTNKDTTEDRPVVLVMHGFMSASQAFVMLGPETSFAYHLADAGFDVWMGNARGNKNSRAHVSLNPDDEVQKYEFFDFSWEEIGMLDLPAMIDYILKQTGKDQLHYIGHSQGGTVFLVMASMLPENNKKIASAHLCAGVGYQEYFPDEQLKQSALMTDMIYYTALQAGAVELFPPNSIQMLPEEIFEWPAYCLGSKRMEYMCQIFGITRITNNYNAATDQPGAALKQMAHYGQNIRDKIFRRYHYGTTGNQEKYGSELPPKYDLSKITTFVTMHYTLNDNLLDERDVLAMVADIPRAVARQVARTSFEHGDFVAAADAKELVTDYIIEEIKKASQENNFPENDQVIVVDDPPTSAPSTETSATAAPDASPGGAGTMVLNVYLIMLSLYVMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L927</accession>
    <name>A0A835L927_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L927"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="47663" checksum="2DE73858835088AB" modified="2021-09-29" version="1">MGEEQTNIDFCYTSSSEIMEEDIGDENEQQVDKSLTEERSLNKRGNSEQRMPEKRGRQDDDEVVEDDEGFVTIVRGHKRAARRDSKEVLKETTEVEECVVCVTSNKERFPKQFGMAKWLRGSGIENITKMSYKGPYKILIHFENRESALQLISSTKLHEFEYRAYIINELQLAYGILRQVDLEMEEKEILDNLRCEFEIQSVKRLKRLDNSGKWIDSETIRICFKSSTLPPYVYGYGCRFQVEPFTFPVSQCSSCWKYGHLSRSCPNKYLTCPKCAGKHANCETTIYVCVNCKGPHMALNKICPIFIKEKAIRDIMTKNRCTYRTALETYNKKVEYLKNPMHQNDLHKVDKQVNHNNIMQTSSQINITQEASNDNLNRFFITTDAIIHNEIPTSESCAEVDETVECTEFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA58</accession>
    <name>A0A835LA58_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970">
        <property type="entry name" value="PROTEIN CBG08587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970:SF1">
        <property type="entry name" value="SERINE-RICH ADHESIN FOR PLATELETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1456" mass="162936" checksum="7242B04FE160D67F" modified="2021-09-29" version="1">MPPLLKKMFDQESIVSYFGSFWCPAVAPPYDRPLFTSSISGTVTCFLAWFFFSSFQNASYVINRRYSKDKMSPVCHNFVQNAWKKDFCSNCFKSREEHVKQERTTDGSKYLATPFQNRGTYFKKTPPSILKIHPKKKNKRNVTFPEEVCSVIGFGGDDWSDGEEFEMSEETEDEDPFPDTEEERELHRITKSNTDFNTVKANLLADSAAKSYTSLLLGKMQTDSDGKKKTLLVSVTPFGQDNKPSHKSHVRKPAVIHVSEASVEETCNSYKTNIILSSYKETETIISADNTSGTICTEKSLLEEISETLEQNRMTNGNDIRLSPKNSNKPTVVDEKIKESMQDEPEKKEMCEIKKNGIVRQSPLQKTHERPKVNLGRSEFKFCKINIESSSVDSAVSTLNSTANNSLASDDESFSGRTDSDNDDSGHFSETLKCEETVKIKVFSEGDKNIKMSPIGQLRKVDGQANSGYSTFQSPIIDMPPILPKQPDNIFSAEASRELAGEPDGRADPDDATEAPALPKSPIPTLDPRPSFLHGMITDILPAHKPALPEKPKLPVKPVIKQTTKKSVITTNQQQINMFMHSKKEDDDKIIGVLNEEKNNEITEVHEDKAEPIYYAQPVLTKEDSDTSLNSIGKRKAPTPPSSPTVEEYPSIYQRNTAGFQKSDAPIVRELEKRERAIGSAVNKQTRAVEEPIEIKKADGTPEPAPRRNISLSHDNLLLDDKRKGKLKFSIKKLLRIGSSKDLDKKELTVAAVTKMTSKTEEIYDLTPKPKPRLVIIHPLDINGSNGVEVVKSNCEIASNLRRLSHDDVSSIYSGSSSATEPETPKVVSKPPPPPRQSSEEHKTVSGVPKPARPPPPKSAALQKKQKQQAWSTAPKQADSIYANLGEIRSALAPRKPERTASMREREARLELPKRRTQIDDDKDDLDDGPQELVQATNEPVINSYDDVYNSSKYDEETCDSAKNSDSDYEYVHHARSSSPECDSAIKPRESDSQIESRKSEDSSNEYPKYNNGLFNRTSLPYCGSETESEIYSPYSFYSSNDNMDSTGNEDYQNEMTPKTTTNKLRVRKGRSVVHRNLEDNYGAVVIANHEALAQVLEQVQQSATMQPSLRGLKACTNLRWNDFAIQQPKPNPVKAGKRFFYPAIWNSNQGPVNVTLMLYKEQMASQMVCQQSVQPQTLSLNAITEFCDLVPLQQFGEEGEDLVQATIVVLAHAHVDTIHSYGENLHAAEGLTTKEHQLVQTEQIHEAIFMMLQMINGLKCLQARGVEEIPESLTSFIALKEVQPLVSHGSTLNLPSPDDRLNSLWAPKTNSYGRLCILQGLSDEINSKSTDEGHLNSLCKCAIKATEILLPGEKLTPLLKEILHEERAVSLNQAKSVLEFMLWGPLDVVQGVPVEDRELSLQRWLDLERATVLHGLVRTRVQLNVFEQLHLMFLVRSTAKAMCDASVLLEKANVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAN3</accession>
    <name>A0A835LAN3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="205"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="348"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9416897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="561" mass="63155" checksum="630A56FA66868983" modified="2021-09-29" version="1">MEEEKKDDPPPIKRYRREEKSSESEEDLDNYEPYVPVKERKKQQLMKLGRLGQLAAEAAAEPKSSSDNDPDDETSQEEWGRRYNVSLLDQHSELKRLAEARALSAAERQAREEEHILESVAQSKALMGIQYEEPIKTSWRPPRCILELPEERHERVRRQLRILVEGEDVPPPIRTFQHMKFPKGILRGLEAKGIKKPTPIQVQGIPAVLSGRDMIGIAFTGSGKTLVFTLPIIMMCLEQEIKMPFIKNEGPYGLIICPSRELAKQTHDIIQHFVRLNVCRYLCMDEADRMIDMGFEEDVRTIFSYFAGQRQTLLFSATMPRKIQNFARSALVKPVTVNVGRAGAASLNVRQELEPVKAEARTVHLLQCLQKTPPPVLVFAERKQDVDAIHEYLLLKGVEAVAIHGGKDQEERSRAVEAFRRGEKDVLVATDVASKGLDFANIQHVINYDMPEDIENYVHRIGRTGRAGGEGVATTLLGRAADDSVLRDLAHLLREAQQKVPSFLLDMIGEPDVPVPDGQGCSYCGGLGHRITECPKLEAVQNKQASNIGRRDYLANTAADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAV3</accession>
    <name>A0A835LAV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000076">
        <property type="protein sequence ID" value="KAF9417150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="164" mass="19095" checksum="045BFC648DC88F66" modified="2021-09-29" version="1">MQRLRSMISDSESDSDDEYIMRRPRWIKERTILLVDGGYASTSYTLPPLENPRTPAEQLYNESQIRTRNPVERSYGVWKRRFPALAIGLRVKLDKALTIIIATAVLHNISRQRGEPVPPDDPELVLAAPWDELLRSGQMERKSNRPYRNRVRDLLISNYFQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBF1</accession>
    <name>A0A835LBF1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBF1"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="205" mass="23036" checksum="12723F614FC11A01" modified="2021-09-29" version="1">MSILAYNGGAVVAMKGKDCVAIATDKRFGIQAQTVSTNFPKVYQMGPTLYVGLPGLATDTQTVFQRLKFRMNLYELKENRMMRPKTFSAMLSNLLYERRFGPYFIEPVIAGLDPYDNQPYVCNMDLIGCPNEPEDFVVSGTCSEQLYGMCEALWEPNLSPDELFETISQALVNAADRDAISGWGAVVYIIEKDKITEKHVKTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBM5</accession>
    <name>A0A835LBM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alanine-glyoxylate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47770" checksum="A6EB7CE33822FD0E" modified="2021-09-29" version="1">MAYLQSMPKSETIRLREKHVGAACQLFFRSSPLKIVRGIAQYMYDETGERYLDCINNVAHVGHCHPHVVEAGRNQMSLISTNNRYLHDELVILAERLVKTLPEPLSVCFFVNSGSEANDLALRLARIHTKNKDVITLDHAYHGHLTSMIDVSPYKFNLPGGPEKPEWVHVAPVPDIYRGKYVYPNDSQVEEELGILYADEVGKICKESKRKNGGVCAFIAESLQSCGGQIIPPDGYLKRVFEHVREAGGVCIADEVQVGFGRVGTHMWAFETQDVVPDIVTMGKPMGNGHPVAAVITTPEIAKSFADTGVDLIGDVRGRGLFVGVELVTDRETRTPATAEAKHVVNRMREEKILISRDGPDSNVLKFKPPMVFSTQDADRLVDTLDRVLEELDGNRAPVTSIKLQVLVTPIDETKTESSALNTNVKQSITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LC78</accession>
    <name>A0A835LC78_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LC78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="367" mass="43177" checksum="C1530B74F5DFDEA4" modified="2021-09-29" version="1">MATKEKEILSHIIEVYKDMPYLWNKNDKNYMNKTIRSEGFEVLLSIYKNIEKDATVKTLKKKIDNLKTNYFKELKKVKASKHTGAGSEDVYVPTIWYYDSFSFLETTTESCRSIRDTIEDEDILEKASELLNTKEEDWEILGRSIGMQLRDVNQQQHIIARKLISDVIFYATLNKLSEESFVGVTTHQSKASYPWFTPSRSSSAQSEFHPVRTSSPYQSPYPQSPNSPFVTYHPNNKCSPHTLQHPRSTTANLQILVITYHFSNKYSLLTFHNHQSTTANLQILFITYHLSKKYSTRILHHHPHNITANIQILFILYHFSYKNNLLQPWNTQFKSHTPQILYHLYNFISHPLLHIQLRWRRQLMDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LF37</accession>
    <name>A0A835LF37_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LF37"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="352" mass="40646" checksum="6DB5E3926894BD7C" modified="2021-09-29" version="1">MVHVSTNKIHTTHTVPSLHKNSNTFCIYFTNVNKEHYKTTFLQSSNKMEKLRFEFVIKAGEDPKSNIICITSITNSNGGTFLIPEQLQPAKLHDAVIKTQAFQKVRNTLQKRHDKRQIWISVTPEISDAYLDEGGNMQFKNYFLEETRQETSKQTSTTSISEEALTTILENFTEILKDKSKPHNIRKLTEKFIIDKFTTKTSNPTQWMNIFETECTRLGIEEDIKKIEALRLFLEDACLDWYSSMLIKYTVNSEWLTWKQNFCETYADRGWSPISYTNNTISPCITDGTSLNHRLITDIEAVFLNKIKRGEQDRSMHASPCSHLASGKVSPRERDQIRNTLLQCLGTNVSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFC9</accession>
    <name>A0A835LFC9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_012112</name>
        <name evidence="7" type="ORF">HW555_001555</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9423012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000344">
        <property type="protein sequence ID" value="KAH9639361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFC9"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9639361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="246" mass="27463" checksum="403DDA7EE664B01D" modified="2021-09-29" version="1">MSGKDRLAIFPSRGAQMLIKGRLAGAQKGHGLLKKKADALQVRFRMILSKIIETKTLMGDVMKEAAFSLAEAKFTTGDFNQVVLQNVTKAQIKIRSKKDNVAGVTLPIFESYTDGTDTYELAGLARGGQQLTKLKKNFQSAVKLLVELASLQTSFVTLDEVIKITNRRVNAIEHVIIPRLERTLAYIISELDELEREEFYRLKKIQDKKKIIKEKAEARKQAALLAGQDLADAANLLDEGDEDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LGA7</accession>
    <name>A0A835LGA7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LGA7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="11">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="167" mass="18264" checksum="09E0499A6588209C" modified="2021-09-29" version="1" fragment="single">MLPAQQLPPISPWPPDGNLLDRMDDLAHKGSEKLSRDSSRVINWSKQWYGAAGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A386GUM4</accession>
    <name>A0A386GUM4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="3">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_005288</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2018" name="Front. Physiol." volume="9" first="1231" last="1231">
            <title>An Insect Prostaglandin E2 Synthase Acts in Immunity and Reproduction.</title>
            <authorList>
                <person name="Ahmed S."/>
                <person name="Stanley D."/>
                <person name="Kim Y."/>
            </authorList>
            <dbReference type="PubMed" id="30233407"/>
            <dbReference type="DOI" id="10.3389/fphys.2018.01231"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="3"/>
    <dbReference type="EMBL" id="MG596301">
        <property type="protein sequence ID" value="AYD37767.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A386GUM4"/>
    <dbReference type="SMR" id="A0A386GUM4"/>
    <dbReference type="OrthoDB" id="423541at2759"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST N-terminal" evidence="19">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYD37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9417707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="44190" checksum="5625168E2B569756" modified="2018-12-05" version="1">MWRPTFTILQKVVLPSLRDNLNVTKILFSTKSRLPKSTSKLTLVSASIGVLVGAGYGGYTHYKVNVKKTFKPGETEEYAFLKEAPEYAAHYKIINDADTSNLQLTLFQYRTCPFCCKVRSYLDSRGISYEIVEVDAVLRQAIKWSGYKKVPILLAKVDGGYQQLLDSTAIISVLETYLKDKSSELREIIKFYPVTKFVNETGNDTTDIANKYFIMHQANVPDEKEKALEAEERQWRQWADRVLVNTLSPNVYRTAGEALETFQWFEKAGGWREFFPAWECTLMVYIGAAAMYMISKKLKTRHKIKDDPRESLYDAVNEWMGAVQSKGTPFLGGDKPNLADVTVFGVLSSIEGCTAFQDLKKNTAVEKWYYETKNAIERRMGKVIAMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G294</accession>
    <name>A0A835G294_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000720">
        <property type="protein sequence ID" value="KAF9405548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G294"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="374" mass="42883" checksum="FD08FDE2B5C7CFC0" modified="2021-09-29" version="1">MLLERDPDPVQKLFCKVLLEISSYILHLVHSSSRGDAKLDISCCHNPRNLSVVNLYDDDVRGGILDLSEEGFRFEIENCVALNVDRGAKGPDVLGGEEIVVILEKKKQRFVDVIRSLKACTNTLQQQPKNSNRNVNLALEAVLEFDNKDPGDIPLLDNIKKLIDNLKDAMRDNKRRNSRRSLRENTDYLGTLNHKIIKRLNYLEKELHELKQANSLKDCPTNDKNRTVQCLTRGSSGRDEKPDEARKRSLMKGFNISDNMSDLVSEKCDKCNATRIYRKVLKTNMTEVKKTMSSDQTSNVRLKSDNIFLLDDSYVSKDDRKYEHKTKTSTAEMSNELSDTNFISHRAKDWARITRGLEFSSPPHNDIFHPSKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3G7</accession>
    <name>A0A835G3G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000455">
        <property type="protein sequence ID" value="KAF9407593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3G7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9407593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="105" mass="12310" checksum="341206D9EBA9FF84" modified="2021-09-29" version="1" fragment="single">VNREKQTLEVDEELENVELEELQDILPSHQPRFIVYSYKMEHDDGRVSFPMCFIFYTPRDAHMELQVMYAGTQRALAAAVGAPRLLEVREIDELTADWLNEKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4U7</accession>
    <name>A0A835G4U7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_011631</name>
        <name evidence="19" type="ORF">HW555_012785</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Phagosome membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Late endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Lysosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000509">
        <property type="protein sequence ID" value="KAF9407080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000360">
        <property type="protein sequence ID" value="KAF9408789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4U7"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15871">
        <property type="entry name" value="R-SNARE_VAMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9407080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9408789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="218" mass="24490" checksum="A814DAA21CA155E6" modified="2021-09-29" version="1">MPILYSVVARGTVLLAKYASCAGNFTEVTEQLLSKIPPHDDKLTYSHGNFLFHYIAENKLVYFCITDDKFQRSRAFLFLNEIKRRFTTAFGDTAQTAIPYAMNGEFARVLATEMKHYSDSKDLDTISRVHGELDELKNIMVKNIDTMAMRGEKLELLVNKADNLATGSVSYRNTSRTLQRSLFWKNVKMYVIMGGVAALAVYLVGAMACGGLKWGNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5Z6</accession>
    <name>A0A835G5Z6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_012231</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5Z6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000004">
        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9407899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="361" mass="40675" checksum="2AC2D86B3FF0912B" modified="2021-09-29" version="1" fragment="single">GVAGVARRTRGATARGGDKTGRRRRQSIPVRSPARHSNMADKTKVAEQYYAPPPDLGKWESFRIFLWNSETGQFLGRTGSSWAKILLFYLIFYAILVGFFAAMLAIFYQTLDSKMPKWQLDGSLIGSNPGLGFRPMPDSANVESTLIYYKANDKGSVLKWAQIIDDYLEQYRKKGSGVGEASGAEYRVPCSFTTGATGEKQVCDVPVDDFHPCTSANQYNYEEAGPCVFLKLNKIFNWVPKPYNNTEDLPSNMPDDLKQHIKMVSGKPDANTVWVSCEGENPADVENIGPVQYIPRRGFPAYYYPFTNKEGYLSPLVAVLFEKPRTGVLINIECKAWAKNIFYDRYERRGSVHFELMVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G609</accession>
    <name>A0A835G609_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000422">
        <property type="protein sequence ID" value="KAF9407920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G609"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF73">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="886" mass="99576" checksum="81DD5795E59E0C8B" modified="2021-09-29" version="1">MPFFSGKCLSTARLVGKTAIITGCNTGIGKETVLDFYKRGAKVIMACRSMDKAEKAKSDIEERCKDLKDTGNIVLAKCDLASLKSVREFAENILNTEPQINILVNNAGVMMCPKTETEDGFEMQFGTNHLAHFLLTMLLLPRIRNSKPARIVTVSSRAHIRYGINFDDLNYKNRRYNAAEAYSQSKLANVMFSRELAAKLKEHNIKGVNTYSLHPGVIQTELGRHLNETMFWGARKIIGFMLYPFMKSVELGAQTTIYCAVDEKCANETGLYYADCVQTNASPKAQKDENCKKLWDMSVELVKLGDYNPFTAPDPGGRIIMACRNLEKAKEAQKDIEEQCKGQEGTGSLVVEHLDLCRLESVREFARRVSARERSLRALLCNAGVMMIIFVSSIIHECKYVNLGSIKRDLRVLHPTGIIFWMDMDDINFMKTPYTPLRAYVNSKIANILFGKALDLKLKVSTSDTESHKIGFVRKAVPKAHVTVDPGQEHNIKGVSTYSLHPGVVKTGIARYFPEAGWCASIINYLFHHYLLSWCWKTAKCGAQTNIYCVVDERCEDESGLYYSDCAVTTPSKQCRSHSEAEKLWDITIDMLNLHDYDPFGNALVIMDYLSGWCKSQQRLDGCTVIVTGSNTGIGKEAVLDFYKRGGHIIMACRNLDKAKVAKEDIEEQCKGQEGTGSLVVEHLDLCRLESVREFARRVSARERSLRALLCNAGVMMVVFVSSYVHAKHKLDLDDLNFENKPYNAFEAYCRSKSANILFARALADKLKEHNIENVTTYSLHPGVIRTEISRHFDETVWYGASWLFNNVLGLFLKSPQCGAQTSVYCAIDESCADESGLYYSDCAVTQPSKQCQDEAQAAKLWDLTIEALKLDLDKFNPFDPNSHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6V3</accession>
    <name>A0A835G6V3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000352">
        <property type="protein sequence ID" value="KAF9408932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6V3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27774" checksum="31AB8AF50426296B" modified="2021-09-29" version="1">MVVMTQDAAETPLKNITACINSTEMKEKRDAINNCFKNIVRKNLNSSYNEQCTIPELEQKIKEHRNAFTTTCGLRFPNTNMTNLLEYIEFSLSNDSFKEFYSDLDCVKKFEKNISACVKSIVGYIPISEKATHSSFNKKMDLAYSQRNCDENNMVKDCVLKLLRTCKPSTSKYVTSLFDFAHSKCSNLTIKAEPSTTVVSSSPHHMLFIFSVIFGGVSSNVAGILIWIRKKTHFHSVSYEEHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G743</accession>
    <name>A0A835G743_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_012421</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000453">
        <property type="protein sequence ID" value="KAF9407614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G743"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9407614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="214" mass="23432" checksum="17AF0274D18A1DAF" modified="2021-09-29" version="1" fragment="single">VALQFNETTVEYDDGDDPDAVTLLSILLVGIFLSLLIFLSVAGNILVCIAIYTDRGLRRIGNLFLASLAIADMLVAAAVMTFAGVNDLLGYWVFGEQFCDTWVACDVMCSTASILNLCAISLDRYIHIKDPLRYGRWVTRRVAVATIAMIWLLAGLVSFLPISLGLHRPDEEALATQKPPRYPTCALVLTPTYAVVSSCISFILPCIVMISIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7C6</accession>
    <name>A0A835G7C6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000323">
        <property type="protein sequence ID" value="KAF9409352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7C6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042479">
        <property type="entry name" value="Slf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677:SF1">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31870" checksum="76D841ED98D0788D" modified="2021-09-29" version="1">MQVSTKIKASLSEMTSDSDYHSPSGTSEESWKLKQNLICACEKKVFMLSESINNRERIAAMITELGGVVAENTKMEMLATHFIAVLPNDTFTGMMVCALATGKWLIHVNFIYDSFRCKKFLQEYLYEWLKHPKILEIDSTSVEVAKAAVYWHLELDALSAKYPFEGKQIVLIMKRKYRQYYQMIFKTLKAKPVTYDPRTPGSCCTADYCFVDMKIIERVKLRFFARHNVPVFPYQYILVFLLKRGQVEDEFKYLLQDCKKYAKDTMFLLNDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7V9</accession>
    <name>A0A835G7V9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000300">
        <property type="protein sequence ID" value="KAF9409758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7V9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="77" mass="8796" checksum="4A73B6E8C06546F1" modified="2021-09-29" version="1">MEITFKVNDEPKVLWCIKLVCQFAIPDRGGQPMRLTRRSTNHAMMSQREAAEAAQETTVLPTARRDHEIALIFLIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G814</accession>
    <name>A0A835G814_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_008210</name>
        <name evidence="18" type="ORF">HW555_011967</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000847">
        <property type="protein sequence ID" value="KAH9629919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G814"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14128">
        <property type="entry name" value="STKc_CK1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000718">
        <property type="entry name" value="casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001135">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9408298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9629919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="375" mass="43666" checksum="0B182CEA3910CC3A" modified="2021-09-29" version="1">MATFERMLLARKHLIINERYNVIRKIGGGSFGDIFLGINVHDGEEVAVKVESMKARHPQLLYESRVYKMIQGGIGIPHIRWYGYEKDHNILVMDLLGPSLEDLFNFCSRQFTIKTVLMLADQMLGRVEYLHCKCFIHRDIKPDNFLMGIGRHCNKLYMIDYGLAKKYRDLRTRTHITYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRGSLPWQGLKAITKKQKYERISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLTFDEPPDYMYLRQLFRILFRTMNYQYDYTFDWTILRQRKQHMEAGAAPADRRSPSVQRRAAQQPSQPPPNNEVKSVHVTNDSAANKQPVKGHQSVSQLKKKLTAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8B5</accession>
    <name>A0A835G8B5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000397">
        <property type="protein sequence ID" value="KAF9408226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8B5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37445">
        <property type="entry name" value="PROTEIN CBG24663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37445:SF3">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28557" checksum="08F31B8AB373D6B3" modified="2021-09-29" version="1">MKIEMQSQTTELKQSITKSIMDKIDDKLIPLVEENKNLKNKVEKLEKEVEVMKRAEKKNNIVVFGLEEKETSTLELLKEFKKHLNQVLNIKIEDYEINKIYRLGTKNRENNKPRPVLCSFVSNWRKNEIIKNKKSLIKINISEDYSKEVLEKRKALQAKLAEEKKKGNVAYLKYDKLVVIEGKINQDKRKREASTSPTAYHPLSPSNQHKKQQIIASIKANRTNVFDMMRNRSNSLSNISTTGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8C8</accession>
    <name>A0A835G8C8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_011754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000372">
        <property type="protein sequence ID" value="KAF9408617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8C8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9408617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="50262" checksum="9D373C40BCF860FE" modified="2021-09-29" version="1">MTKEYKYMDIREGSFLYNMWANPTYEMFSEMWVFNYTNAQEFLSGADKVLKLNEVGPFTFQEMRTNENIRIDREKGVMTMNPRLNLKFLVDKSVADTHNVTVKIPNIALIAMSTLAADKLGYFANAGAYYSMSALGSKLFKDLSVEGNFYSQKNETSEVELANVTRRYSLNSWDNTSGLLEQGFTDLETSTPCNRIKGSFEGLMLPAHYPKGKNITIFRKQACRNYPFSFITESKSESTGLNSYLYTMDPTAFSSTSPFACNCSDGCPPEGFVDVSNCYYGFPISLSKPHMMDTDPVQQSYFSGMKPDPKKHGSHFELEPTIGAPLSFSIKIQINLAVRMNEGNPITAPFKDKVLPIMWFALYCNQPPSEVTSLLRLRLLYAPPLIVTLEVILIIVGLVLAAQGLHRIWKPKYKIIPPKEMPVPIVRRKSGNDFVVVYKRFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8H9</accession>
    <name>A0A835G8H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000277">
        <property type="protein sequence ID" value="KAF9410102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31079" checksum="12E574F9218D21F5" modified="2021-09-29" version="1">MDVCFIHKITMGTSNKRGSQWQELMQSFCEKRKETCRASSIEAPVTKSVTKQFKTKSKYKGGWGPLGMTGYGEYTFPNGCSIIRGVWENGVMKSRTLRFSDTLEYDEYKWKYCVPPDRRFDIEYQTSIQPAGKSYLTAQQPTNEIPPGYYDTGDGLYSPNTKVVYNYHDLTSIKRATSEQEQRWIVENCRFADLGPLGPRPDMYETYQQPTDLLTPPPPPPTTSIPKIISSQFDMEYHTPEKDFYDPSKFSSPSTQKLDQKLPSNHNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8V0</accession>
    <name>A0A835G8V0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8V0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36103" checksum="E94B811149C4212D" modified="2021-09-29" version="1">MSKVKTNGGDSAQDEKILMPYTYIQQVPGKQIRQKLASAFNYWLKISDEKLRAVGEIVQMLHNSSLLIDDIQDNSILRRGIPVAHSIYGVASTINAANYTMIVALQKTQELGHPMATTVYTEQLLELHRGQGIEIYWRDNFQCPSEEEYKEMTIKKTGGLFMLAIRLMQLFSDNKSDFSKLSAILGLYFQIRDDYCNLRLQEYTENKSYCEDLTEGKFSFPIIHAIRNPEGDNQSLLDILRQRTRDLEVKRYCITILERLGSFAYTRETLHGLDEEARREVARLGGNPHLEALLDDLLSWRREMPLEKLDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8V8</accession>
    <name>A0A835G8V8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1349 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8V8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55931" checksum="8CF26A7C381DA03B" modified="2021-09-29" version="1">MDSSKYSEIKLSDYKWINEPKKWRISDKGLEVTTDEKTDYWEGTWYNFHHNNGHVYGVQIKDDFTFEVCVEAEFSHLYDQAGLMIYFDDKHWLKAGIEYNDGQPMISSVLTNELSDWGTGVFMGNPRKFYLRLSRKGDVVCVKYSADKELWTLLRLCPLPGCTRGPCVVGPIKYSEITLEDFKWTNEPKDWFIKDESLQVTTDDKTDYWGGTLNNLFNNNGHLFAVELKDDFTFTVCVEADFTHLYDQAGLMIYFDDKHWLKAGIEYNDGQPMVASVLTNELSDWGTVLPPAVQERRRGVCEVLGRQGAVNAAETVPAAGLYARPLCGGTHDHWVTGIHTTGHLYGIEIKDDFSFTVCVEAEFSHLYDQAGLMIYFDDKHWLKAGIEYMRNGQPMIGSVLTNERSDWSTGVFTGNPRKFYLRLSRKGDVVCVKYSADKELWTLLRLCPLPGCTRGPCVVGPMCCTPTRQGLQVTFSDIRITVPADDILHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G969</accession>
    <name>A0A835G969_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_011388</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000332">
        <property type="protein sequence ID" value="KAF9409171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G969"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="569"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9409171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="892" mass="99557" checksum="296DB1BD63FBBE79" modified="2021-09-29" version="1">MGDKIRGASVVSHLQAMDNFGYREMGWPSPLHTPAQTTPMRAGFRGSSVRSRAPREPEEFPLNSNYKHVRNIDLLESAREPWKAKEYLFVGPSPPAEDAPNMYHSFDVLAPDPEARLTEEAARRSLCEKALTLGAARFFDDVECGLITTENIQEHICSAPEVVVNLTLLWAALLARDELLPAILEAGADIHYSEPEGLTALHLAAFSGASRAAIFLLSRGADVDFAPKYFAPLHCAAFGNSLEVAEILIANGASLHAVVQRAGCEDNLVHCAVRADAVECMELFIERGVDPAYVTSGGLNALHLAAELGAQRCLSYLLKETKISVNGVTKQRDKECTAIHLAAARGYAECLELLLSEGAKANTKNYRGFTALHLAARCSSIECVEVLLRDGNADPNVEDYDKRTPLHAAIGRSERACDIIDMLVSWGAQVNKKDEYGYSPLHLAAMDNLTQCVETLIFLGADVTSKSKKGHTALSVIARKTPKSLAILRHNLDCGISLNQPSESNEEVQIEFDFGRMLKFSYPREITYLNSLIDEGQKDILLHPLCSAFLFMKWRKIRKFYLARLIFCFLFVSFLSIYVLTAVVKTCKGKYAEKYGVLNELCQKQSLLGLILTNNPIEFERWVLMAITAFEILRKLTGITGYSSFYQYFTTFENLMEWFVLLSVFSLYKIHNDYSWQNHVGGYAVLGAWTNLMLMMGQLPMFGDYVAMYQKVLTEFLKLLLAYICLLLGFTICFCVVFPNEEMFSNPLMGFISTLSMMVGELNLNILINDPTKDDPPLIFELSSQIIFILFLMFVTIILMNLLVGIAVHDIQGLRKTAGLSKLVRQTKLILFVEMGMFSAWLPKCLHKYVYRTALVSPEAGKVILSVKPLNPREKRLPTDIMMAAYELGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9F8</accession>
    <name>A0A835G9F8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoporin NDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_011132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000311">
        <property type="protein sequence ID" value="KAF9409538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9409538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44637" checksum="EB1F4A9D09159015" modified="2021-09-29" version="1">MLMFPHVYQDKFQQIKLAVNSILSMGFRNSIMPVAYYCIFYYLWGNKPRSVVSEVYSLYLEDPPLDNVFNLMKSGIWIGLWFYTSLFFVSVYTMRTIFNIVLTEPMKFPIESSRSLVLHNALALRAQFNGYLGAQDLRIMSMTDPARRQQIYTLSQPGGHPRNWNNLMEQCISIINDFSKELDAVNGDGKLNEAEASKLKNGNVSTSNGFQFSGNLRNMAQSPKLKELKDHNKNKQEDTFVNAVKDDFNSFVQKLCQKPGISYLFGELTDTKLKFLLMQAQPVMWTCEGLACIAAASLNEDKYGVVQNDLPIVISTLINLKQNLDKLTKPGLVPRKHILNDSFAIKMKTALISSVKRSIYKIAITFSKYIHEIPLDPDIQVALQPFLMCKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9G0</accession>
    <name>A0A835G9G0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9G0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="444"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="563" mass="64975" checksum="D722D116A7A1C921" modified="2021-09-29" version="1">MTELKKIKDSKSSGSGTDTIYIPSVKWFNLLDSYLRNITESESNLSFVCSCYVLYCALFGFSDTLTTLHFPRTSIPTTYDYFGLCDTDTDLLLFDWELPLRLESVMEPSLRLLCINCNICVNTLRRYEALQLDTRVISLLSTWISPVIISHSDHVCHACWLRFKRQALSMQQQDERRGLDGEETLQGEETLQETQPPLSVVSTNEEQERESQVVQAPEIQSSKITLLNYQRALNTASHCIFYGCENLNLHTVSDSLRATILSNYNFYIPKLAWVCTEHLHGNSWNFLYGSENSMTDFTLEQVEHVFSFVQKFKSFLDFSSRESIQEIDDHLFGYWMGLTKAKFLNLLEELPRLLEKHRGILGLAAILIKMRTGDSDLRIATLLEVPRTTLERLMKTAREVLLQDFVPRNLGLNHLTREQLKEHNLMIPNGIYNENNEQCIVMCDGTYIFLNKSSNYMFQKDTYSLHKYRNLLKPFLIVACDGYILDCFGPYKATTSDAEIMSSLFSNENSPLRRYFQDNDIFILDRGFRDSISLLENCNYKANMPDSLLEGEHQLTTTQANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9S2</accession>
    <name>A0A835G9S2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000248">
        <property type="protein sequence ID" value="KAF9410746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9S2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="85"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="185" mass="20989" checksum="EB3BBCE64C14FC0C" modified="2021-09-29" version="1">MASEQKKNAPENKERSLQKQNIPVQLTDLSIFDNTFAFMKEQFAEEMRRIEQHMSKLSNDLSKLYGQTSTVQTGIVQNADNVLSNWDVLTNSPLVQGEGEEKKLKLQFDVSQFDPTEITVKVTDDLLIVSAIHEEKTDDSMVYRGYNREFKLPPGIDPEQVLSSLSRDGVLTVEAPLPNLMLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9S4</accession>
    <name>A0A835G9S4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9S4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22298" checksum="A5EE83C69DF83E1F" modified="2021-09-29" version="1">MCHAHFEDKYLCRNNRISNIAVPTLKMRSPLTPPSTTSLQQLNLGHGPSPSSLTATMQEAALPSTSETNVHLNLGEKTTVKKAKSRVFLTNTEKYLQDKLVAASIKLSKMKNRFKKLSVNVKAAKQIASNPAVCDILENCTSTRKLLISMQCQEDHKKEKERRFTLQEKIASLSIFKQSPKGYRFLRFFLFCLLSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Y9</accession>
    <name>A0A835G9Y9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase Suv4-20</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_010387</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60348"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.362"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000258">
        <property type="protein sequence ID" value="KAF9410538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Y9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="349"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="554"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9410538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="698" mass="79486" checksum="CDDDDB96018B315C" modified="2021-09-29" version="1">MVVGSATYPGRQVLHKMQPMGMTPRELSEYDDLATALIVDPYLGITTHKMNIRYRPLKTNKEELKSIIKEFIQTQDYNKAYSRLANGEWMPRHFSKNKHQQSKLREHIYRYLRVFDKKAGFVIEPCYRYSLEGRVGAKISTTKKFFKHERIDFLVGCIAEMTEEEEKQLLHPGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRPTCTFEATDRGKAFVRVLRDIEVGEEITCFYGEDFFGNGNCYCECETCERRGKGAFSVQNAHNDEQATRYRFRETDNRINRTKAKQSQKNVNGKNPEKSRISSRQNSDIVSPLSMKEMKQKGLTKYDAELLIAQGCIADVIEGNVSKEAQGSRESSASSRGERLRRRTDSNRATNGMTIVSTSNVKRRAPPSRCCSTTSSRSSRDSHSGIVLRSHKRLLDTCSQSTCPKPKNASKQSSDVKTDRNLTTPKDETEMNVLETNKLNIKTEPSNDSQKENIDSVDTTDPHLDKTDNDCDKIESPLQITDLGITASEGKVEHSVHDSNVQEQIHDNKCVSDNACVKSEIYDFRENVNPSESKESKQNKNPKIEVTSRTEDVKKEAESGPPWLVDNSNKSSECPCTPPRRGLKLTLRVKRSPVVEEVMDCGNTTEATEYEVLRLEGVDPETARRLKKRRRSKERHRKHSPIRPLPPMKRLRLIFGNESRTIDLPTAISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAL2</accession>
    <name>A0A835GAL2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAL2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23829">
        <property type="entry name" value="RWD_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="289" mass="33665" checksum="F66A5BD90932EE93" modified="2021-09-29" version="1">MAVSPKNAMREVVVDCLSQQIDEYELLKSMYPNQGEINLSDKDNVNEIRSFIDNKTDYIPPHLDFKLNLLVDGLKLEIFINLPSSYPKEEPDIYVRCNKMNRQNESAINSQLSQYIKENHIGEVCLYTAISWLQENVDKFALISEENNMLPAKSSQETKDEFARLWIYSHHIYNKKKREEIVKKARELKLTGFLLAGKPGIVCVEGHHSDCKEWWKDIKSMTWKKIMIRKTEIFEPSEENTFKKFSSFEELCLANPVNNKHSNMSELSKLMTELGLNQIFNDLFGLNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBJ2</accession>
    <name>A0A835GBJ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBJ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22049" checksum="E44D4C17B9C0F909" modified="2021-09-29" version="1">MKLIESESELNLEEPEPATAMDLEGQSTSTSFAKEQPITSTPKRSKSGIEASFAKILEYSSGGTKNNQIIKAIAEMVCLNMKRKKALIIKNLGSVNNLCLTIDEWKDLQMKSYIYMGVTVQYIENFEITSFNISCDPLSERHTGEYLLIIIKNICKEWQIPDEKVVSVTTDNAPNIVKAVEIVFGRAKHIRCLNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBK0</accession>
    <name>A0A835GBK0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBK0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="177" mass="19635" checksum="BFD55D1875C5AB46" modified="2021-09-29" version="1">MALIRAGLQGLAKVFHGGQAGILSRFVTNLSPVESKTVPETTKDVIAECNNLIEKNASRNFAIVHLLGKQWRVTDGDLLVVEGFWPPSIGDKIRLDKVLLAGTKDFSLIGRPLVQPGLVDVTATVISKGLSHTRTHFKKKRRKQFMRINFVRSPQTILRINSVEIANKINEAPKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBK9</accession>
    <name>A0A835GBK9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chorion peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBK9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF106">
        <property type="entry name" value="CURLY SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9412543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="67156" checksum="6CA13E343E6A7FED" modified="2021-09-29" version="1">MSTCVLSTWSAELASTEDSTGSAITCRTLPGALPMAPFQRLIGPLFADGINSPRIAHHGKDLPLSRVVSRTMHPDEGFHDHAGTVNGHRLGTVHGPRLHADSYSSCIPTAMRIRIPDDDYFYRLFGVKCIDFVRGFPSPRPGCRLGSRVPFNTLTGTIDGNTVYGVTEKFARKLRTGFGGLLRMNPVFKEYGLKDLLPLKLDIPDEGCTRPNKNMYCFEAGEIRVNEQLVLTVMHTLMAREHNRIANGLAEVNPHWDDETLFQEARRINIAEIQHITYNEFLPILLGKDVMEKFGLVVEKEGYWDGYDPEVNPDVIASFASAAYRFGHSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYVMGLMNQVAQAMDDSITQEVTNHLFKKVGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPPADTFQDLFGSMPNATVQKYETIFDHPIDVDLWSGGVSERPLPGSMLGPTFACIIATQFSYSRRGDRFWYELPNQPSSFTPEQLKEIRKARMARIICDNTDIIDTVQLYPMVLPDHELNPRVPCRSGIIPMMDFSKWAEPAPSPFHGAAKQFVSSFSYDPYLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD43</accession>
    <name>A0A835GD43_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD43"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17310" checksum="26AD50C840221F53" modified="2021-09-29" version="1">MACERNISYHEMPFCVNAPCNDFYIYTDLKDVKEKCLTFGDEVIKCRTIGILKSINGRFYLTDLDETECQSEPLAQVSMVFLKTPPQSTVIPYPVQIFGTLQWKNRPVIFAKLLQVMTVSTAIRMKNSLGSITSLHLARNFLVYEEQQDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD48</accession>
    <name>A0A835GD48_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000160">
        <property type="protein sequence ID" value="KAF9413412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD48"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="53" mass="6263" checksum="2F7C2EE843E22381" modified="2021-09-29" version="1">MMTLACYQSQMKVYCQRNAEAIHQASLESRANLGAIHFCDYFYILIRLDRFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDN6</accession>
    <name>A0A835GDN6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000191">
        <property type="protein sequence ID" value="KAF9412368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDN6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032832953" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="294"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9412368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="530" mass="57688" checksum="645B11E62D3241DB" modified="2021-09-29" version="1">MFKLAIVLAALAVIRAEDGVSNKYYLYTLENQYEPEILDPTAPFSRYSNFKITDNTVILVHGHQGHLNSNFDNLIKDAILYHQEPHNVIVVDWAREAGQGYSDARKAVPLVADHLANFITWLENEARLIRSTLHLVGFNLGAHIVGQAGRRLDQGLGRIGRITGLDPAASRWGSDSGRLADTDAMYVEVIHTDITGPGSNGIGTAIGDINFFVNGGSNQPGCIGHVCNHNRAYEVFAASMSNSGLLGYPCSSDLQNTLNRCKGDPLHMGGLALSKTGNGEFTSMIPNNPIPDLFKPAEQTIFLIHGYNGNTVRFNREVREAILRNLGQNNDDNVIEVDWTQGMGSSYTQARLNVENVANELVTFIQWLTTPPSVGVPANAADMHLVGFDLGAHVAGIAGLNPAGRQWGAGSRRLYRGDAKYVEVIHTDTLGALAYGIGDPIGNVNFYVNGGNNQPGCILHSCCHDRSFELFAASMSNPNLRGYRCSSMTQMNLNLCRGDGLELGGTEISKGVEISSNFIYRINTRRPPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDT8</accession>
    <name>A0A835GDT8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDT8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032843">
        <property type="entry name" value="Jiv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052317">
        <property type="entry name" value="Viral_replicn-host_int_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14901">
        <property type="entry name" value="Jiv90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="575"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="821" mass="93088" checksum="65B3086CCA7252D0" modified="2021-09-29" version="1">MARSPKDDPIYNDMKHNTWNYHAETAGNCVPDALNERKPPQISPNPSVMNDNSIYVNPSFGNEVYLNKHAYNVQSGDAAANKDDKIPFNNMPNVPRANQNYGNAMLKLSNGQSVRVFYDENNQQLIFPMSAGQYELFNHNQGVRDIPLQMPQPSHMFTLNQDFAMNNNNVHTPPTTVNQTTYPENVTNQSPTSNFLKDLLGNLEPNSTGTYSPFGQNYPLNHPDASNMNILTNNPVIEPPKNQPIKVDNSPKRNENSPLADTSNKKRIVAEVKPMRPSYSDVLAKNTKNTSPTETTRKAKPQNIETKPMNNKTNSKPEKQTNIKQDDNKHKSEKKQNTNTISSGSESGDINTDDNEKRQKPNKKSKNKRNNISRKWSSLDDITNEEESGYTHDSESQFVFIENPEKPSKKEKKSDSKSKGSDKNATTEDEFKLDEEDDQLQFVIQEGQGESGKAKKKKDGRNYHKVTKPVQDKKKNVSKLRRNKPGYLGLAQNYLEHWGGATWKALIWFMYLLSDICRMSFHLSFDLCTSVFTQTYVMELETDNGNDSTKLNANIPLPATGEEAMKRLLACKGKDPYSILGVSVTCTDEEIKRYYRRQAFLVHPDKNQQPGAEEAFKILQHAFDLIGEPERREAYERRALESRHVEAAWSELSQLLAQLHDKMEFAANTIRCTNCGRRHKRVLTDRPCYAARYCVQCKIRHSAKEGDIWAESSMMGLLVMYYACMDGAVYQITQWASCQKKNLKQLRPDCHVVQYRIVLGNKAAAASDINQRPSTGHDPNLEEFLNNLYSKSGVSANATSPRQSPPDATDAKKRRNKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDX0</accession>
    <name>A0A835GDX0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDX0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="21013" checksum="393299F709ED0CAA" modified="2021-09-29" version="1">MDVPSIDPVHLKNIEILGNGLNLTFSEAEMHGLSQAKVTELKVDVGKGEGQFSLSFKGDLNLTAKYVADGRILILPIKGNGDALVDAQGVEVHIDCKLIHEKDSKGDHMKLATPKYKYTIERTVFDLKNLFNGNKQLADTTLQFANENWQQLMDELSPPAIKQIVRTVVKAINKFLSKVDIHQIIKGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE12</accession>
    <name>A0A835GE12_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_012634</name>
        <name evidence="2" type="ORF">HW555_007588</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000688">
        <property type="protein sequence ID" value="KAH9632809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE12"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9632809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="16028" checksum="4A81F8E330C450AC" modified="2021-09-29" version="1">MDRNGYFFYVTSTAKKKKINLMQPKPPRVAFVEEKRRPGVAERIYTGYGSVASSATENGRGDSMTQRGPSPAPRARLYTQLESYQPRYHTIRDNSDKRVESECRRRKEKRIVGYPQPSPVVRYIFGGKAKTLEIVIKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE56</accession>
    <name>A0A835GE56_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein furry</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000138">
        <property type="protein sequence ID" value="KAF9414234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="517"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="2">
        <location>
            <begin position="742"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="4">
        <location>
            <begin position="961"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1547" mass="169143" checksum="93044D475E3A9285" modified="2021-09-29" version="1" fragment="single">SDKGRGTLDVLLCTTYCRSQLYLSRQLSQLHPELTMPMFSEITARFQTARTEVRQLLLQYLLPWLVNIELVDPNVPPANPLSYIQYYASEAGRSGRREGLGSAEATEMVLNNLFYITAKFSDNHPKEIEELWSTLCACWPNNLKVIIRYLIIVSGMAPNELLPYAKRVVLYLARSRPERLLDEMMTELQTVETLNCLIERTETPPFYRLTSMRKATSGHSDGPCTGSQDAAGRTGELAPVEKGTIHTKRHSGEDPAKASAGLLHPPADEEPPPPSDGDATPTGLCPEPGLMPVPGSAPATPQETRMDVPQPRPLPMPEYGGFFALLTEYLPDTTQPISGFHRCNVAVMLLCDVVLDGVELDWSIHVPLMLHIVFLGMDHTRWIVHQHCRQLLLNLLVAVAAHHDHLTVARVLLASRSQQLGLGVPQPALPLVPHNFTEPDAAFDSYPQCGHSPRSTRALTQFRSTSHTRRQVGMQQQVKNTTCGRVVSVDAAQLPADVDTLLRHVLRVFRESLPHALISERWAQTALQLGLSCPSRHYAGRSLQVFRFIGVAMTGRMVSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLESNFRPLDYMRDIFKSTPNLNNKDGGQPNNGSPYTAGKRSPGVCVGCVTNHTRSTSYSVSYCLRKNNAPPPNADKQAHAERARPCSEAAKGVCSNLCRSRSAQSLKLLGDSATQLPGALLQDDKLTILATLFWVGASLLESDYEHEFLLGGCTHPNTYEPVVGVLVDMIPLLELPVIDPTQSLAFPMTVVALLPYMLLHYEDANELCVRAACHIAQFTAEKSKKLENLGTVMTLYSRRTFSKESFQWTKCVVKYLWDTYSHLSQQMLAFLVEVLEKGSANLQLPVLSIVHCMLYYVDLNAPAAQPVNTDLLRAVAKFIDVTVQDSNNYKEAMKILKLVVTRCSTLVVPPYWDNNASSILDTELHGKKELPGRTMDFTFDLSQTPVIGRKYLPKAGSQPATGPSSLSNASTATPDKGSSTSQSGSASTVVGPEPGGGNNSTQPQSATSPRRSLSLSPADAVASGWKRPWMSQGRVRECLVNLLTTCGQRVGLPKSPSVIFSQSSELLERESSMASSLEEVSGTPGNEPSGGAPPTDHFGVFKDFDFLEYESESIEGESSDNFNWGVRRRLPSEERDEGAAVERSPPLQLARPPDAHPVIKPSTHEDSSDEEGGWDDGAIGSRGEGDAGVSHELVLRPRTHSFSSASSGEHDGDRGDVTPVPSAACAAGRDAWRASVAALLRHAAALPPLALVHRLHTVLKEVTSKTVSLCAESTTGGAAGVAGVAGELAGVLAGVLERAGAEEPPLLWAGPAAADCARVRDAVRYAALEMHEHLDTYFDRREHALEVLELARSSPEEVARSLYRLIFQLLLLLETNNKMIVAVYTAALENKGVEMSGAVCAVRNQVMASAADSWVEHSPAPHDDARLLHLIQRQKWGAALALVRERNAERILERGELPEDDVTALLHVYCRGLAQAHPDMVAITRPVHELSQNLSFMMESLYKVSVALQRQEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE80</accession>
    <name>A0A835GE80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026104">
        <property type="entry name" value="ZNF_C2HC_dom_1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649:SF1">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9413452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="486" mass="53212" checksum="8CE01981200F4C13" modified="2021-09-29" version="1">MPTVLRKWDSASNVIVNSIDSRQPAGGAQRCVGADLTPPLRKNHGTARFQQKQMQEREMKIASLYEAQQARALDRVRHSPSNVGHASPPLPPPTHQPGKVRQMFEERRTKAGIDKSYPLQPIHNTDRPAARKPLPNGYNKVAPSKVTVERKVNKTHTINSHTVKRQQVHKTENIVNGSGDLNHNHEPDMNSVKHILPQSNGEVILPNTDELDKVDNNYLLENETFPEALAPTPTPRSPDPPAATKKPPPRRSPAQRSSPAKTKPQPSPPTAAPARRTTSDNAVPESNKARGAMQRAVNPVVTRRQPLSSGSVGGAAASSARRGAASAAPASAASGAACTVCGRHFAPDRIDKHQEICRKAHAKKRKPFDALKHRLAGTEAEPFINKLRKAPANPASSTKVNKNLNNNWRQKHEEFIQAIRAAKQVQAHLSAGGKLSDLPPPPPSENPDYVPCPHCGRRFNQQAAERHIPKCANYQFNKPKPAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEA3</accession>
    <name>A0A835GEA3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligosaccharyltransferase complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_007102</name>
        <name evidence="7" type="ORF">HW555_006629</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OSTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000511">
        <property type="protein sequence ID" value="KAH9636150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEA3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042416">
        <property type="entry name" value="OSTC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160:SF4">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9636150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="149" mass="16624" checksum="C20113DDFD4CBCE2" modified="2021-09-29" version="1">MEALFAIPFSVLEVPNIKIKKPTWLQPPSAMTTFSLVLLSYFLVTGGIIYDVIVEPPSVGSTTDEHGHSRPVAFMPNRVNGQYIMEGLASSFLFSLGGLGFIILDRTHNPTTPKLNRILLISVAFLCILVSFFTTWIFMRMKLPGYLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF92</accession>
    <name>A0A835GF92_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000171</name>
        <name evidence="3" type="ORF">HW555_006865</name>
        <name evidence="2" type="ORF">HW555_013577</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000671">
        <property type="protein sequence ID" value="KAF9405847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF92"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="91" mass="10597" checksum="4AAF24E1282DA5B0" modified="2021-09-29" version="1">MSQLEEEKKKGNIAYLKHDKLIVKKPGDNSRDKRRREPSDSPDQTTQFKSDLAKKVNHPRPKMQKNTIIRPNILNYVEKTRSDPCPNSPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFM6</accession>
    <name>A0A835GFM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="583" mass="68059" checksum="B2DC5EEF693A386F" modified="2021-09-29" version="1">MKISYKLLCNACLCVGRKLHKITDEKTQKYYLNALDEIPLYNPSSVSLLICWECKALLEKSVAFKEQVQDSYRILQTYTHENLHECLLSDVSRPPRLKLHKTDPVNILPSDGLETFSEPINCLKYEFKEEWRDKGDKNTSNDGSVLSDSSDNTNQFEPDIQDVCSAKRGEKRKRTADKIKRTKKDKRKLNKNLQDCLASDVSENRLKSTSEPTNLSSEEFETFPEVPIPKSMKDHNQKILTIELTYEEMLLERDRESTRDTYLKAEYKCETCLIGFNYKKSYLAHVAGKHSADQGDYICPICKTIIPSIESFTAHYKRHMRSSIDTHRYHKDTHKARVQCTEAVHEYHNAFPCTICDKVFRWKTSLKRHLEKHEVKGKTSSSAAYCSMCNVNFSSICSYQRHMKNSLKHVTQDQLKFICDHCNKRFADKTKLRDHIEEKHLHKTYQCHICLKPSKNRVGLDQHIRNVHKGRPNNKMCHHCGKGFPTKVQLESHIRTHTGERPFICEFCPTTFSQQSNLYKHNRQVHLNIKSKRYPLGKRKDDRPPEMQPLDPTPVDQFRLPMLQYTNEKSFFAVLEDNDMPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFN0</accession>
    <name>A0A835GFN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 57</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000230">
        <property type="entry name" value="Leucine-rich repeat-containing protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27291" checksum="39588A46B93ABC3C" modified="2021-09-29" version="1">MGNSSIKQHYETASKTGVLQLSDYKLKEIPIEALNLSDKLRNLDLSKNKLSSLPNDICKFKLLKQLNLDTNRIETIPDSLGNMKKLEMFNMSNNLITFLPESFAKLSNLKQVYLSNNKLKEFPSQLLGLHSLEVVDLSHNKITEIPKGMSELYAAELNLSQNEISIISDDMHLAPRLKILRLEENCLSIEAIRPNLLRDSKMHTINLDGNLFEQKQLVSIEGYNEYTERYTAMKKKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFX4</accession>
    <name>A0A835GFX4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_011364</name>
        <name evidence="8" type="ORF">HW555_007044</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000121">
        <property type="protein sequence ID" value="KAH9643583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFX4"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9643583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="95" mass="10518" checksum="D7C54AD0B32C9311" modified="2021-09-29" version="1">MSNPQQIFNYTDESQADRLARKSKDSPFMIIGIIGLLGVCGFGAYKYKTRGKMSTSVFLMQLRVAAQGTVVSALTIGLAYTLVKDHLLKDDKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG80</accession>
    <name>A0A835GG80_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24158" checksum="CD6BDE720A3AB3F8" modified="2021-09-29" version="1">MAKRHTFPAHTVLRGKPSLRAVSQPLTIISQATVSPSSSENSSTMCNDWMQFMKKASNNIWTMSCALNGNYVAVIAIIVVVIISLILPDITQKFHATHTHELKAMKKVLDKMSNEVTRAEVACLTVADEICCLHCNMHNDTTGTSTEELQNLPTCSSHCMRTTQSEPVQVEKKVGFFRRLFFPNRNTSHKEIAIMSYVYTDSFDAKEQVEDQQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGN8</accession>
    <name>A0A835GGN8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_006430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGN8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="249"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9416178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="742" mass="83566" checksum="8F022FE1848E5FBE" modified="2021-09-29" version="1">MPKEQYRETYVGRKISHVTFNVDSPAAIQQAAHIQVITKNLYAQDGQRVPAPYGVLDRRMGTNQKDANCDTCGLGLAECVGHYGYIHLALPVFHVGYFRSIITILQTICKNCSRVMLAEPLRRAYRRKFMNPELSYLQKKNLRAAVHKKAKACTKCPNCDSLNGMVKKSPAGILKIIHDKYRTKKPTDAVVKRVLKDFHEAKESNKELTTMINSGLIVEMSPVEVLDIFRRIPDDDIPLLGMNGLTRPEHLILTRLPVPPLCIRPSVVSDIKAGTNEDDLTMKQSEILLINDVISRHIASGGKSELVQEDWDYLQLHVALYINSEMSGIPLSMQPKKPGRGLVQRLKGKQGRFRGNLSGKRVDFSSRTVISPDPNLQIQEVGVPVHVAKILTYPERVFPANLQWLRKLVCNGPDVHPGANYVQQRGLKHKKYLKYGNREKIAQELKCGDIVERHLVDGDVVLFNRQPSLHKLSIMCHRARVQPQRTFRFNECVCTPYNADFDGDEMNMHLPQTEEARAEALILMGKSLEANFTLKMDQLGAQIKAAGPAKETVAKIAEEFRAFRELIYSVLGLLRKQIAECMLHIDVLESKQRRKSLIFQGLPEAENEDCSSIIHSILSSKLGLKQITIANIKVAHRLGSSGTDHPRPILVRFSCWDVKSSVWKAKTGLRGTKISVKEFLTKTRQSIFTKARQHFGMRSCWSQDGVIIIKASDGSRHKIVSMDELKPLLEKYPSKLTGGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGQ9</accession>
    <name>A0A835GGQ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="6">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="235" mass="26024" checksum="4F4D1213EA073BDF" modified="2021-09-29" version="1">MRKKAGGVQEDALMAVSTLVEVLGEGFLKYMDAFKRYLYVGLKNHQEYQVCIAAVGLTGDICRALKSKILSVFGDIAISIGPNFAKYFDVVMQMLLQASNAQVDRNDYDMVEYLGQLRESVLEAYTGIIQGLKGPTGEVRSDVALVEPHVPAIVTFMMQVACEPERTEGHMSVIAGLTGDLCMVFGQRVLPLLETRPLLDLLQAARRSRTPRTKALANWATKEMRKVKHQTPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH84</accession>
    <name>A0A835GH84_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BCL2-associated athanogene 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_005297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH84"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021925">
        <property type="entry name" value="BAG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12057">
        <property type="entry name" value="BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="308"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9417590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="671" mass="73258" checksum="61B4F2F9929B36C5" modified="2021-09-29" version="1">MYITVEQLKEKVREQMGIEPSLQRLIFCGRVLQDEKRLAEYDVNGKVVHLVQRAPPGPETRQSAPSAPTANSGSENNGSNMQQQIRRLMSLAGPSDILMDQQVTMSPTTGRLEFIRRMIAEIKASLASLRAHVEGEENRSSPASGESPTEQMDTEPASGTQHDEPEPLLDENGDETTDAAARAQNARRRSYRAIRALRARHTRPRDLAQLLEELETLQEQFAPYRANYIRMLRAANNPEPPVYTEEERVSAQRTVDMVTDIMHSFAHAYHAISDINFQVGQRNPRLTSDTSVVRHPIPMQAHINVVQSNRRTPQQQASQPQSQSQSPQTAQSPQQQQPTAQPAQPAQPAGQQPTGPATNTATRPAGNRAPTIQTSTAGDGITSVQGVQPSGHATAHAGRTTQPTVNINIQPDPITYQVEIETRVPIAFPLENALLNGLTNAAAVVNAQEQGNNGAGANRRQVLLDFENLFRGLSQSAGLGGVEVVMSMEEIPHGGPVGVGTILTVFVGPMPWGGAPSADLLQNIVSSVIRQGLVPGVEGVTLHIPSVPTAAQLAPVLQALQNPNYQPATLLAPHPNQVLEALQAAQAAQAAQQNAASLHLRRATTTTRAQAVSLATLIYDRFLQCDSQHARRRLQRRREQQQQQLVQQERARAERVAAQNIEYLMHQKPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHE2</accession>
    <name>A0A835GHE2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032783328" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="144" mass="14481" checksum="B8692AB066C92F39" modified="2021-09-29" version="1">MPFLNLWLYFTAAPFGGLGSTPASTAPSLFGGTGFGSTAAKPATGFGNTSFGTSTFGTTPAFGQSTFGSTAPTFGTNTLGSNTFGAPFGGATNTFNSGFGAKPGTGFTGFGNLGAAPQFGQVQKFCLSSFHMIMGDFIEESLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHZ3</accession>
    <name>A0A835GHZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1386" mass="158071" checksum="3792F28D7AD3355A" modified="2021-09-29" version="1" fragment="single">NDILSFGFRMHDAIEMTSQHHGRYHSSVSPEMRREEQSQCPSLAENPICPCYNFKEGLFLECPSATPGVVKNVLSKIRGTIQSLSIYDLEISTTELNADIFPPKIKITNLQISQSGINKISPNAFTSLRDSLGSLSIISGKLSKIPHESFLELHNIGALDLQLNDIKEIQANTFRNLKLKKINLKGNKIANISENAFYNLEESLTELDISENFLTVFPLKPLAKLNKLSNLRLAWNKINSIPDDINVTVPNLVSLDLNSNYFTRIEKYWFRCMPRIRILTFFSNQIQHIDEEAFYYLEKLETVDLSRNKITTLAKNIFQKNPSIRTIDLSHNHLHHINGVFSNLHELSEIFLSENNILEISDDAFINAFGLTVLNLEHNAIQKLHPNSFSSLQNLTQLHMGTNFLNKLPRSVFQSNRKLITLSLDNNEINELDELVFEKLDDLKEIRLQNNKLSQIKRNVFSPLPGLLELHLQNNLVQTIDSHAFITLKSLQHINLQGNRLTTIGDVFPNRNSSLVSIQLGANYLSMLKNSSLRGQMNVQIMWLSQNNIKILTSNLFNDLLNIQRLYLKNNSIVHIENRTFMHLKKIKFLDLSNNKLIKLSNETFYKLVTLEELYLQNNHINQVTKDTFQFLVRLKILDLSQNDIVIFNFDISSLPIKQLRLSKNSIAIIEVDSLKSLPNLSDLEMNNNDLTWEDIIQIQIPGLKSLIISENNFTLLENKTFAHLPSLQTLSLELSNISQLPPTTFIKNQNLLRINLAYNNLRDLHKDVFAYTTILQELNLKGNNFTDFPHHALFNVTSLEILDLCSNQLHSIDFFKFIGLQNLRSLNLCNNRISMLNGFNSPSLKNLVTLNLSNNMLTVLPPNFFHHSVGLKEIDLSHNLFKNIPSNGLSEAVLPALTTLNMSSNSLVQLLQTYPSKLFPLLEELVVTNTNLTIITSKDFENFPSLKRLILSQNSIIRLSPGAFSKLHNLELLDLSQNKLENIPRERLQGLYSTRVLNMSQNVIRELEDFTSDLQSLQKLDISFNHITRINKDVFRGLPSLTELYLSGNWLSAISADAFRNLNKIAFIDLSRNYFEVIQMKMLKVLETQIKTIHFNENPLTCNCETQEVWRWMKEHYKIVIKGSRNLRCEHPEDLHGYSFIELPSQKLCDIPIVIRIAIQDIQTYSIIVSWQSRNQTGLNAYQVAYFSEDNPTTIRGKILNATARSTRLNNLTPGSRYTVCVIAVGSFGPSTSTGFSVPDARIALSPDITSINNLYSDEQIFNHLRPYMNDSLSSKCTSVRTIEIFGAAIDSPFSNTYMDIADILTRRLSLVVGCCIGFIVFVVLVSALGYIKTKKRQVIVKAEVQQAPQYISYDNFNTPGVEVQTTDMDINTITDKTKVQCKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI12</accession>
    <name>A0A835GI12_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000106">
        <property type="protein sequence ID" value="KAF9415631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI12"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="536" mass="63213" checksum="0A47163A1377A80C" modified="2021-09-29" version="1">MQIENATGVSRKCFIPDNQPLSSATLKKDEVFLPYVLYTKTKEKEKLRKRLGLGLCDRYNAVYAEIRSRIHMDDPPNDILTITDFDPGFFQCLNCTFLSRYVAPYKSLKYSFNLQLRLRQECGYRNDSMLNIETNFRREQEIYDKSTQRYAEQVKYFEAFILADYMKSMVSLNKCEELTLAVNKINFEYQCLAAKMFTITSRIVGLDYRYGLQQKYGRFLYYLSPPSWRFKNRQFARSMEIEEKGFDFGISKDEDTFSVMFEKLKMECYSGLTKPVLYFKHHGDLMELFDGIEQQHLHHFTHVVQLSPHTIFLKKGIQLFKDIIAQDSAGIHATIKDFKKLLQFSEDQRSQLEAKFFKIVNGFFYECVGAPEVLKFQLHLEFCYEKIYNEKPINMDIVGTAKALENFYMEYSKRLDEVKGDKIEAAMSVYINSERQKFKQAKDAAKELRMFRRLELTLLRAHAPPTKLQANFNFANNTRLRKKKLSKAKCEEYRNSLTEAELEYLTLFTDWTEKEDPDNYLQRRISRNDVGPGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIS0</accession>
    <name>A0A835GIS0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_008615</name>
        <name evidence="16" type="ORF">HW555_005234</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000066">
        <property type="protein sequence ID" value="KAF9417727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000862">
        <property type="protein sequence ID" value="KAH9629571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIS0"/>
    <dbReference type="SMR" id="A0A835GIS0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9417727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9629571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="49927" checksum="587195A3DCBBE373" modified="2021-09-29" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGAGLGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDESYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFIPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMMNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEEEGGDEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIW1</accession>
    <name>A0A835GIW1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIW1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="752" mass="85385" checksum="D7C48BB32D3D2433" modified="2021-09-29" version="1">MNQQELKRQRSRNVISHDIADSHRRQFSPSRMMRSPLGSDTENPVSERPRVVEPAKFLEEFVKIFKGRDRESFPVLNNVLSDFDPLSREQTIEMWISKVDECAEIYNWNDRQTVHYALPKLVGHAKTWYQGLPTIRHSWKEWKVLLRESFPSTENYAELLTEMLNRRARPGDSLELYYFSKINLLNRCKIFGKQAVDCLIFGIEDKGIRLSAQAGKFNKPEETLEFFKTVKSHPREYSEGIRREGTSKDNKRFQSFTATSTNSEATKIIDKTFRNRPKGNAVCFNCKEVGHMSYQCRKPITKCSECNFLGHDSNICPKRSNNSNNGNVSSKNINDNKPKSVLEVSINDDSNDKYRVGIKINGVVIACQVDLGSQATLVRKADAHKIGLQWDTVQGPLLRGLGSIPYVPVGKTFVTIEIQDIREEQVEVLIVDDSLINIPVLLGHSFTERPNLRIIKTATDLRFEKVDVSGEVKLLLVTVDDFELDIGGLRAVTVGAKTNYSGSIYVGGSIRGKPDREYYLLPGEYQMTNGVCRVLIQSLSSKKINFCKDALVSRARTTFSQDRLLDVLQINTELVNESHVNSIKMGERLTISINTSIHDVTKRSPTELLFGRKLGNPSQGILNNVSEEILISETNEPIEQIRSDASDRIKENQNKNKNRFDSHRKSPNKYKEGDLVRVVRAIVSGSGKSKKLESKCQGPYRIKKVLPNDRFIIVDTPLTRKGKAYENVVAIDKIYPWMSFDAPSYSSSDESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIZ0</accession>
    <name>A0A835GIZ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_004104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9419340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="124" mass="14139" checksum="E1B82F4CD6A9755F" modified="2021-09-29" version="1" fragment="single">MIQFLFFYSLEKLLYLYPRDSEGNEALKEELTVSMYCPNCWPDCELTDHSIKSYKINFLRTGASGFSNSFLSGVDLTNKSIINIFQPTGEGILHRLDVVSYWYEILSNIGSFAGVMMGMGIFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ61</accession>
    <name>A0A835GJ61_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ61"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="639"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="672" mass="75757" checksum="487F11EE41F3B425" modified="2021-09-29" version="1">MKINKMDKNAYETYEFLPTNSSETEPDQFFVLQDDGTFLLNRQIQYVAQVQDVKEVLDDVQPCTVYGVSSQQFFVDVDNSAELISVSGDFEQNQFILPDGDNGLYSNSFLLQPSTSGNTEPMEEDVVVDEYKQQNTQDVDVDIDVVTYTSKQGNNFTEITISDEQYQMLEQKGWILLESNDKIFVLNTLGLHDITTNDKLVQKLKNETQNVTGNIMGANEGTLKIETISGQFPNIGAESLSDQQETVEFVIKADEPNNTIEGIQFVVDDKDSVMSETTISDITHENFDKISTKEEYPSESLVSEILAEQKQNIVVDNEPKSFKIKTKLTFKDIPEKIVLGKTANGKRLVAKVLKPKSNKIEKPKDNQVLKQTTLRAGIQPSCTEEDIASAEGVITQLLKMPNLKHFLVGYDLIVTKAKNNKDEFGLIYNRSPVSFITGRVADKDGSCGFEHVPNLLQTIKQKAEEQNVSQSDEVYSCIEEKEAKENFTIYHIHITETKCSDNIVRVSVTLNKRQLPVNLVFDLKKRYPTTVFGCSSCAALFKTEQTLKDHQENHCIDTDDMLTIDTANSTNSENDDDVIIVKTGKETVFSCGQCNVTFTKLSNIQRHMKSHLGTKQQILQTTRVLKEDLDPKQKPTKIFKCKMCPSTYFHSASLSKHIVTRHIKVKSNKNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJM8</accession>
    <name>A0A835GJM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF29">
        <property type="entry name" value="PROTEIN SLEEPLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032974823" description="Protein sleepless" evidence="9">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20475" checksum="F31A3B161A501BE6" modified="2021-09-29" version="1">MEYCMLAVVYTVLSLITTGVSSLQCYHCLINPPPGQYYNTTKRLCVHFDHSDKFIVECPYSTMCMKQEFHLDIQNGVRINGVLRDCAPQKHEYQDYKNGRWSPKMEILEPYKEGCINEDDKGQRSTPTRYCYCRNNLCNTSPSSSHEGYTDIMGVIVVFNLMKYINSLRVFSRTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJQ7</accession>
    <name>A0A835GJQ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJQ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="204" mass="22739" checksum="35C11F6BC0229F3E" modified="2021-09-29" version="1">MSIWRPYLDDVATDVPLNLAVTQVSQSDAVSVTYPACLSNLTYPEYLAVPPQHYGPAWMSPGQYGYYQFPSAPSPSPSPVLAPPAAISPPKSSPADYEDAEISEDEDFQLFKKIAMDAMAMRNGGMLVGSNPRMRRTVRSAAEDDAYRRTREKNNAAAKQSRDRRKLREIHLSLKVTYLKRQLAELKAALSSQTCIRCHRSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK94</accession>
    <name>A0A835GK94_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK94"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="270" mass="30070" checksum="6ABADA905F4AFB5A" modified="2021-09-29" version="1" fragment="single">AWQGGLNVRFDITVVGIGVTAFIELPQSNTTAAEKNWVRLTRPEGPAGLASLVLWCPPTDYTVCVLIDDTGYIAGLQIALDIEKVTGNTFDMRTQGFTYWTTNLNGETKNYWTTQQNSCDRPSNRIAARDPHVLLQDHSIYVSGFNGELLAISTNTSDIAHNSDFTEQACIPGMGDHYYYKMTPELKCTEDNLMPWFPLVHSDQLIGLGMVTYGRHTVSEGATDWFETPTRGVIMAIVPRGPQCMYDLADSPGVITMHTYFIKHPYEVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK99</accession>
    <name>A0A835GK99_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK99"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="479" mass="53569" checksum="3EC65D915C391288" modified="2021-09-29" version="1">MTIIVRLLSSAPSQESWFSAFLLTVARHLFLPEPLQSMNGEPVLVPHEFMQLRVLLRNYIHNLTTRANSQGSDTSVLAVTDFFVSEFRDFINGMSNITPLRDEFDAYGSIRSLFRARLPALISAVMSDSTGEMYPARFYAVFSRLYTDFCTLISHLCVEGLDGLRQLYKTFLDLRIRYFDESIQEMVLVLANENLNAIINTLGSHCAHIQQHLHRRPGVPSEPSPPPLEDEQPTPMEVSPSSQPAPEEPAIINESSQSSAAPSVQEETPLSTSSGSVQVVASTVSATPTSAASHTVTSNTAPQSPITSPSRVMTPKERSEPASPARNASDQNLRFVPPLMILQHWGEEWVPVFTRDQQNQRPEPQEPYSDAYISGMPSRKRRCLRQTRPPTTLNGFMEESLREAANDRPATMQAQAQDNAPMRIAFREYMRNYVRERAANSTDYDATRFTSAARFINMNRTSTVTPPQENGGGQPQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKM9</accession>
    <name>A0A835GKM9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKM9"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="30494" checksum="41EBD962C4A92FAD" modified="2021-09-29" version="1">MAPPQPKAAAKPAAAPAGGVAKAKVGKSRNYDLGNGVVRFSKTRMFHKKAKYRFVGKKNPKPEKPKKPSVAVKQIGGEKNGGTRTVLLRRRKSFYPTQDKIRTRPHHKTFSKHVRRTRPTLTPGTVCILLAGRHAGKRVVLVGILPSGLLLVTGPFAFNSCPLRRIPQRYVIGTSTKLDLGDFKLPEHLNDEYFKKNKKSVKRSVKRKQGEDIFASKKEKYVPSEQRKTDQKAVDDAVVKAIGKRADKKLLRGYLKSSFGLRSSQYPHRMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL46</accession>
    <name>A0A835GL46_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL46"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="27601" checksum="0897D3A65F5C9EF2" modified="2021-09-29" version="1">MGKKKNKEAKKKVNLVFDESKRKEFLCGFRKRKLERKKKAQEELKQLLKQEKKRIKQENKESYKKLVVSSRPIPDIEQLLQDEYEDEDVNVKIVELSADTLQKKDLVIGENRPKEKIQTPQNKNKNKDVVRAAVVPGMGSDEESVEEESEGEEDEDNKIKTKKEIKSMLKKQATKKIQKSKVFQMKSKLDRIQNKKKSLQKKGHMRGKADPRKGHGKSKDNPRKDKSKKKVGRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMI3</accession>
    <name>A0A835GMI3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMI3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25033" checksum="DA84B08FE7A0A2E1" modified="2021-09-29" version="1">MTDASETTKTEMSMFTATVAATTDREVEDVSKRDKLSLKEKDLPIVHDQGFFQHQTGDTYDGYFEAKKKDRIVKMQGYGVYTTAEGDRYQGNWDQDKFGLNDEVVITYLDGAKFEGTVKDWAYFGKGKYTYPDGGYLQCEFADNCPIGNLRLIDPNGHIWLGKAEQGFAWFEPVNHFYDFLETTCPTRSKRFDSKSLHGTSSQLAKKSLSRSRQKLASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMX7</accession>
    <name>A0A835GMX7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF169">
        <property type="entry name" value="GH15759P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9419525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="273" mass="30101" checksum="FBF5177677A90CA4" modified="2021-09-29" version="1">MKSNPTTFQIIPPNDLNALRRTSFDFSNPTVIYLMGFSESTSGVGTTTVRDAHLAARNYNFIAVDWYITAVRNTRYMGRKLAEFIQFLDSVGVPASSIHVVGFSLGAEAAGFAGKNLRARGLLLGRITGLDPAYPGYSLSNNDGHLAKGDAAFVDVLHTNPGVFGFLRPIGDVDFYANPGSWIQPGCWVDELFRNREFRFVYGCSHVRAWRLYSESLSNPRGFPATLCRDWTSATRPCSFQVDGYMGIAAAPPMSGKMYFKTNPRPPFARNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNK7</accession>
    <name>A0A835GNK7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNK7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000097">
        <property type="entry name" value="Probable chitinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF403">
        <property type="entry name" value="CHITINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032757255" description="GH18 domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="32"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="509" mass="56891" checksum="F0C39C931EAB41CB" modified="2021-09-29" version="1">MNVLCLIFFAGVAASVHGQTLVEEVKGPKHDKKVVCYIATWAVYRPDPGRFSLEDLEPALCTHLVYSFAGLNETSNSIKSLDPWQDLETDYGKAGYKRLVALKNKYPHLKVTLAIGGWNEGSPRYSNMASKPETRAAFIKSVLLMMNNYKFDGLDLDWEYPTKRDGKPYDRENFVLLVKELSEAFEPYGYILTAALGAGKSTMETAYDLAKLSRYLDLIHMMCYDYHGTWDGVLGANAPLKGINENDTLSVEWTVEYLLAHGVSPYKMVLGLPMYGRTFLLTDPGSRVLEYGSTPVKATGFKGPYTGEAGFMGYNEICVETMNKSSPWVYHWHDQSSTPYLRDGEKVISYDNGRSIAIKVKMAIDKGLGGVMVWSIDTDDFRGNCNETDAYIDFVERHRRMVNDPVVNKAAKNLNIPDVSLVGSKGPAYVLEDNTLQLRLPQPKYTNYALMQTINDAITLAIEEKKILDEVKRLESDNEVRSEDKGGNGHSIKSSLFGIALCALVALQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNX5</accession>
    <name>A0A835GNX5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029179">
        <property type="entry name" value="TOMM5_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28436">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28436:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9257" checksum="029F07D0E1D99D16" modified="2021-09-29" version="1">MGLHPKEYSMAAISVCLKLATTDSPSVHCLLISTIMFRLPYGERVDPMEEKRQARENTISSVITFAILCAAIRVAPIILEHSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP09</accession>
    <name>A0A835GP09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_003403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="114"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="352"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9420342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48800" checksum="47DC7183DD5B76BB" modified="2021-09-29" version="1">MCIKICKEIEVMCKLMRYGVEVINNNVLIRHNETLELFVSFKEGKVSYGTDSPARGRRVIFCVHGNPSTGCCAVIETSADGDDGEQRNGSITEVERHCHRSRNEEIDKRARRKLIIASILCVIFMIGEIVGGYLSNSLAIATDAAHLLTDFASFMISLFSLWVSSRPATRRMPFGWYRAEVIGALTSVLLIWVVTGVLVYMAIQRVIYKEFEINATVMLITSAVGVAVNLIMGLTLHQHGHSHGGGGHGHSHGGNNPVLNNKERSDSDAESAASGHTHTHAQENINVRAAFIHVLGDFLQSAGVLIAAIVIYFQPSWSLVDPICTFLFSVLVLITTFNIIKDTLLVLMEGSPRGVDFQEVANTFLSLPGVVRVHNLRMWALSLDKTALSAHLAIRTGVSPQKVLEEATRLVHDKYNFFEMTLQIEEFSDGMEDCSQCKMPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP94</accession>
    <name>A0A835GP94_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_003284</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP94"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="790"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1155"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9420534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135895" checksum="108E156E2E33BB9C" modified="2021-09-29" version="1">MPDVMDWKIDCKSCKRIASLFSEGKYNAITHSEVGRDIERGPDHDEAAHPLLNPAESGDFRIRMARPRHLGLDGRPPLPKLIMPDLTPSSVGSTVNSTPMMESGAIVPKPWRRGDRRLQRLNTELLEAIETHDLEEVERLLNVGASPNATCRLGFVSACHTAALIGGDALSLLIKFGAEKLRIDKLGRTPLHLAAWAGNARQVAILLDFPEDIQERVGADSMSSETEEDVRKLCPLIKEMTNVRCDLGEVDMTLPKPWRDNIDHNCRDIKGSMPLFQPGWTPLHVASSCARKHCTRLLLAAGADPNITDLEGRTPLDVAGYAYYYEQDVNEKHFVEVIKMLLKAGGTFNTMKNSSLDNMDTPLHTAVEIESLDGIQELLDAGAVVTCLNRAGQTPLHVCVKKNLEEHLQLLANYDYMNANPLLAIVDVKDKEGHSVLQAAVEAAWVPGVCIALEAGADVTSKANDGETPIHSAAALGNLDVLNEILSIAKQRDAIDYQNEEGETPIYKAIINGHVNCVKQILNEGANLKITLPGDVNILHVAADYGHVEVLRVLLEFNETVTDALINTLTAGDRRGFGPIHFAVFNNHVECVELLLSKGADIRLRTTSNPHKSSTPLHLAAVKNHLDIAKIILNFDKTTVHEVNSMGWFPLHAASHHGSRDVITILLREGADLSGYTDGPKKYRRTAIDMIINNLSKPTEFMEDVFDSYISSNGTDLQDHNCEVTVDYGILMPTVCEMEQMKVIEALLKTGNRNGQRRLLVHPLVESFLFLKWKALLPFFYTIIGLYAIFLLSLTVFVVSVFLFRDTHEKRPQWLDPVIWSYIVYATIAMILIQELLYMNVKSSRYFLQLETWVKFGSLGFAVILPYTIVVVNLNDDEWPRHVATVALLLSWLEMMFLLSRFPNWGYYVLMFGKVASNVVKILLTFMFLVVGFSLSFMIQFRSQIPFDGPWAALVKTIVMMTSEFDYGALFDEEHSKELATSLIIVRIIFLIFLILAAIVLMNLLVGVAVNDINDLEVLGNIRRLVKQVEFLGTLDTLVYNRLFSAILPKRVNNSLKNKRNVLCVMILKPGKPRWKHSRTLPSRIKDAIFTKAQAQQKQIEDELGLQTFKTKLSEMHDAIMALNKKNEEKEKPDILKLPSDTKARVKFDEVAHHLHDLDDAVVEMKTQNQEYVEESKCAMEELNSKIDRVSMELDTIKQFLTRLERKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPM6</accession>
    <name>A0A835GPM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retinol dehydrogenase 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032339556" description="Retinol dehydrogenase 11" evidence="3">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36538" checksum="E987E571F8D16651" modified="2021-09-29" version="1">MYGILLIIALVIIIALVVGIHQKNTNAVCLSRRRLEGKTIIVTGGTAGMGLEMAVDFANRGARVIIACPFEDEGKNARNLIIQQTENQNIVFKLLNLASLKSVRQFAADILKNEDRLDVLINNAGVGAPRDKLTQDGLNFIMQVNYYGAFLLTLLLLPLLIKTGKPGEPSRILLTTSVLHRIGQMDFKNMNKTDYWYKIQIYGNSKLCLIPFASELSKRLEGSHVVVNNVDPGAVGTRIFESGSKLLGFFLRNIILNLFKTPWQGAQTALYAALDKKAGEVSGAYFRNCGLTRAVNRAYCEKTAKILWEESVRLVQLTNEEVEQCFQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQS9</accession>
    <name>A0A835GQS9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="27682" checksum="A9C25FEE39810DB8" modified="2021-09-29" version="1">MLTERTEDTVSSSGNLTNNAVRHKIVVLGAAKVGKSSLISQFLYNTFSPKYKRTIEEMHHGDFNVSGVRLTLDILDTSGAYEFPAMRTLSMQSADAFILVYDITDANSFTEVRTLRDQIHETKDSTAVPIVVVGNKVDLAETGARQVEFHTTESVVTVDWENGFVEASAKDNVNVSQIFKELLVQAKVKYNLSPALRRRRRQSLPTGPQGPPGSSPTPPANAPHVPSPAQLAHLQQIRERHNSKRNSCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRN2</accession>
    <name>A0A835GRN2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056199">
        <property type="entry name" value="SPEF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054517">
        <property type="entry name" value="SPEF2_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24082">
        <property type="entry name" value="SPEF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22946">
        <property type="entry name" value="SPEF2_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1778" mass="208173" checksum="AD44D710BED2B509" modified="2021-09-29" version="1">MAEILKEWLTERLQRPIAWEAEEFGDMMKNGYVISDVLYSYNVINDEKHFLIRASLAQEDIKSNWKYLTEWLAELNVYLSANDLENIMDGKSSAILTLFYKMFLHLDKRDRTNFIKRERKMVSSLIEKMGHRFKVENIPEEEESVVDDLAKPLLNERHFIEWQRKKSKQVKDTYEYIRHKYSRMLRNIKETSTPMCSQKSTLPPKLTNKEREDMEKFALKYPCKFENYTYDQLVSMEMKAKEQRYSFSDSEWAKAYMNNLYGRLHKKSDSEEFQKQLRNVLSGSLWEHSVAEEENKLDTELAKKVMKLSQFEKQMCTQIMETKQQARNLVKNRILAEREFAEQRELQFNQFLDNMKEQIQSEKTEIDFEKERQNILHKRLYGEKMKRKRLHYYDICYETVLSIIDYATKYAYFKKLIGEDNIPEHYLHEWKVLYYKQQPIFDILEPPEDILKEKIVEETAPEEEEIVRLELERQDALNDNEFKVYHDYSYPWTLDLLIPNYDPESEERKYEYLGTRILGHVVYTLLGIKYPYPPPLPPANLPAYKVKALVRGLPERSLTVPMQILLSSRKIHVVRIENVINFCLRKFKTEMIGCTDIDLSFDKFIATAPEEEDKELIKLMKLEDDTFNKSNESALAAMLGVVTANSKQTQTPKTIPEEEIKLSDAAELGRYAYESLGIGDTLTDHLLAAMIVQYLKDEKDISGFVIINYPNSYREAQILEETFSGRTPPNENELEDIDDIYLEDCIAKHRRKQKDPHKDARVSRLVSDPHKKRDDKPFESFFTCYIRLKESLDILQELVIWDLTESNSELIDRFYAALGINYSMYYEAIDKEILAQICKYIIGDFSLPLKSADRLFGENVLSCLEFPANDDKKQKSKIIKPETINGKSKEKMQSSKPSRSSMMPLEVVKEPSIEELVDEPSPEGTDGEESYRTQSIDEIKLLAGEEDWEYGDLPIPTVIGVALATCWQEIEKVYINDMQQLFLAKRLQMNCLIPYARFIKDKMEQIITSPSNKQDLVCKFQRDYNDFESDWRDINAAKNEWHCRIKELQHKLYNICDDRKLRAEQQRLALISDNWTMEELTSLVNTYISCMQAELNRSFMTFQSLHDFYFSMIKHMPSNDKMSFKELSKIYRDSDDVSGSRKGAEDKIFRQLKLGFQELQLKNMEIDFENNPFNLVIENNVKFALKIIKETNDSYRSIIAKEYSEIAKVQPPLKKKDENTSEESVNAEELFKVQALKCIDEWTMGINGEMYRASLRMQALQYKCYRDMKLFNDHIYKTFTDIQNDINNYYINEIKSVDRLCKYLQLAVENGRPIQETLVLENDTFMIDPNLLQFAPPEPPADTTKVSETVGSMDFRISQLAALRSQFKIIAPTGIIMQQAFIYLLQDFFFFGKESCNGPLFPEAWQRVDPEQVPKLVYLMFGDTVYIDWRDFLIYCLNIRFPNVDDLLELRKRFRCYDLSSTELIDRDDFISEELWFEKDFDPNDKHAQLRLNLIKHFLFELFETMENKMNYSAFLLAFCKDLNPINGFTTALSMAVGKKTCFDLEQCGEVVCKLIKQKKYRDECLACAKKCTKEFIDKVLDKVIKRCEGTSIVELEYIAPVEEKKSKKGKAGKSAKKVVEPVMNARVKSQKSLLSKSKTSQSAGAVKNTFICPPCEDEAEAEEKISEKPESIVEVKILEPEEDPNLMYAVSQSVIWNVLRICLPWHFVLVPEAQKTPYIAQVTDVLKRLEDDTDNGDIYVCRLVIDPDICTLLHKVKKFTALNLADEVVKVFASRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRQ9</accession>
    <name>A0A835GRQ9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39956">
        <property type="entry name" value="GH09530P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39956:SF1">
        <property type="entry name" value="GH09530P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="439" mass="45496" checksum="7921E1D4AA6A10DE" modified="2021-09-29" version="1">MLVDDRNAEVTGGPLTWPLQAQVIYELRSGLVPLSLRVSPPLRSSKKIKRIPKYDSQVGCRKWAESYRARLYVGQYISRIAIQFLLYGMLIMDWRTVICAFALVYYADGFSKYGRTCKDIGCLNSEVCVLAEDPCTFGHTSNCGTYPTCKKKSQVEGSHVEPAKPPAPKPPTRDFDSPPNYNPPAPPSSDTSSGGHSPYGGSSPYGGNSHSGGNSPYGGGSPYGGNSPYGGSSPYGGSSPYGGNSPSGGSSPYGGNSPYGGNSPYGGSSPYGGGSNNRGGSPYGGSSPYGGSSGGGSNPYGGNSPYGGSHSSSGGFGSGGSGSPLDSILNTLNKYANAGGGSAGGSSGSGGLSNVFGNLLGNLSKNGGLSNFFNTRPIMENPNYSSYSSNSRSSNPQSYPSGSQPVYQPPTQNKNYGQSYNHHNAATTRKPVHYGWNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS24</accession>
    <name>A0A835GS24_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS24"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="203" mass="22670" checksum="837819D745F9FB19" modified="2021-09-29" version="1">MYTTEIFIVLSCTIAVRLVIARNIVKFNMKKFYPDEQKVHMIDMTGYDRAAHPEPLPTMASKTGFITYSSLHQGVKLRNDVVVYNQTFNYNGTEEGQRILCQALFDCSIAYLALESSEAIPVLLRGGVGYRHFMAIIKAKPYRVLRGNVQAFCRKKDGRRYETGASANGTKKVEHDAATNELGVDARSNPVDQPVAATSNIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS77</accession>
    <name>A0A835GS77_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS77"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19513" checksum="473CB0A61E0FC551" modified="2021-09-29" version="1">MAFFNCGRLGSRSLLASINKVPTVLGSASYAQAAASAPKIVYKKFEPPQIEHHDDRNARLKRPMSPHLSIYAPQLTSILSVTHRATGIILSGYFGALGIGALVLPHDISHYITIIENLNLSPATLFVAKFLLAAPVGYHFANGIRHLVWDMAKGLTIKEVYSSGYAMLGLTVAITVLLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSY2</accession>
    <name>A0A835GSY2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSY2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032490369" evidence="2">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="173" mass="16584" checksum="D1AA34F7CC75A9F7" modified="2021-09-29" version="1">MKTLLCICILVATCMAYALAIPVEAAPGELAEGIAPLLCMCILVATCMAYALAIPVEAAPAELAEGLAPVAAADDGLQTTGSRFRRHHSGFGGLGGGYGFGGGGGFGFGGGGGFGYGGGGGYGGGYGGGYGGGYGHGGGYGGHRGGWGRGGGWGRGGGWGRGGGWGRGGGWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT95</accession>
    <name>A0A835GT95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46954">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46954:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="475" mass="53328" checksum="5C943792A101BFF2" modified="2021-09-29" version="1" fragment="single">AIFKQILSGTGGAACSDLDSPLPGNERRPHAYAPPAARLGMQSPNASEKISVLPMTSNEPNLPVKLPTPAICVSPIGTEITDEGNVTTKSTSTGARKRKGEDLDCSDENSPDTPSASSSILQPVRATPAQDKLKNQISLLQMEFDLAVRRRDFLGATENETRDVTKLRREIDKCTKELRKKEQHMRHSQSHRLSIKSKIKLACNQSPIVADLLKARSAPGRPRLEEQQPQLLKTIVDLAMFGASAEEQHRSEIVRNLPSLQWYSEHVRESQYLLQVVKCDDRACCGDLRSSLRSILPARFVIPPYPILQSSSGLCIPKPQEHDGKTFATFLLRRSLGITPTHEGFNKLPYDLYCPSLQKDRRQLMERTCQWCGLYFCTKKKVKEHVNSCHKQPNPSSNSVEMHNVRPSRILTRRSIGRSKEILCVVRENDDTEWLDETDVDFQQSTVPTTDLQDAYPVVSVEECLANPWSEDNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTP3</accession>
    <name>A0A835GTP3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032590321" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="21894" checksum="7731FC1AC71E0127" modified="2021-09-29" version="1">MQFKLFILVVTCFSSLVPSAVAFHLLAAKAAASDAAQEIAAISMDTLSTKKAVLAKAAADMISVIAQGIGSKSSIIATAAASMAGAVLNGTLSIGAALARAGFNIIAAKLSSAPTVVVESPSIVVKPPVIEETIVEEVVQPPQPPALIECDKPKVVEVPYPYRITPFGSVSVDVKPKVVDLPPPPRVSEWTVKGRPAFEIIAPADSSYIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVB1</accession>
    <name>A0A835GVB1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07132">
        <property type="entry name" value="ALDH_F3AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="424"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="563" mass="62749" checksum="D9B4EE17D06B0129" modified="2021-09-29" version="1">MTLGIANSKPKQQNVAEAVEKARDAYNRGVTRPVKWRLQQLKNLLRMYEENQNAMIEALRKDLRRSKMESVMLEVAYLINDLKSIIHHLEDWVKPEKPEKGFVNMLDDVVIYHDPYGVALVIGSWNYPLQLLLLPVSGAIAGGNAVIIKPSELATACAAFVAETVPKYLDNDAVIVIEGGPQETTELLKQKFDYIFFTGGTSIGKIVYEAAVKNLTPVTLELGGKSPVYIDNTADIMITTKRVLWGKFINAGQTCIAPDYILCTKETQDKFVAAAKKILQEWYGPDPQKSPDFARIINSRHFSRLQALVDASKDKIAVGGSYDANDKFIELTILTNVVASDKIMQDEIFGPILPIVPVENAYEAIKFINERDHPLVLYVFSKQKNIHTLFTEQTQSGSVNINDTIMFYAELQTVVGFREKPLVLYVFSKSDKVLSQIVDNTSSGGMCVNDTMMHLAVESLPFGGVGASGIGAYHGKKTFETFTHKKSCLIKNFSPIGEKLASGRYPPYTDGNLKMLNLLLRKRFGPSLKFLPYFLCFAVGAGLSYGIFAWQKVKKCCLKILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXY3</accession>
    <name>A0A835KXY3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_014151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000876">
        <property type="protein sequence ID" value="KAF9404816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXY3"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="73"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9404816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="334" mass="36672" checksum="A5B76A8BB598BB27" modified="2021-09-29" version="1">MAGPAVLPKSVLEKAQSELVNYENSGMSVMELSHRSSLFETIIENAETLLRELMNIPDNYKVLFLQGGASSWSKKAISEAKKIDTVEVQVIASSEDKNFTYIPEVHLEDIPQDAAYLHITTNNTIEGTTIYDLPKTGKVPLIADMSSNILSINYNVADFGLIYAGAQKNIGPAGLTVVIVREDLIGQVDVLSAMLDYDIHAKNGSMYNTPPTYSIYIAKLVFEWIKEQGGVSQMEKLNKEKSAILYNEIDASALFSSPVNPKDRSINNIPFITGNDALDKKFNQEAIAAGFENLKGHRSVGGMRASLYNAFPKVGVEALIHLMKKFESENGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXZ0</accession>
    <name>A0A835KXZ0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000685">
        <property type="protein sequence ID" value="KAF9405769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXZ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="59" mass="6433" checksum="1047AEC66C3581CB" modified="2021-09-29" version="1">MIYFARDLVSLPPSLAPSRELVIFLASVATRPTSRHACVEQGAHVIIIAQSSASSFEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYL7</accession>
    <name>A0A835KYL7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000656">
        <property type="protein sequence ID" value="KAF9405965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYL7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9405965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="702" mass="78632" checksum="3D0B279E34854634" modified="2021-09-29" version="1">MSCNYADGLSPYENKGILGVPEKFDSIEKFNKKCELLAQLINQANHVVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKRPTTNISFADAVPTKTHMILKKLVECNKVHYVVSQNIDGLHLKSGLSRKYLAELHGNMFIDECNLCKRQFVRSSPVETVGKKCSGVPCAAEHVTGRPCRGRLYDGVLDWEHSLPENDLTMAEWHSSIADLSICLGSTLQIVPSGNLPLETVKYDGKLVICNLQPTKHVSTLLFKESLFFYCVVVSSKTRNYVFTEYIVFCSLNNKAITFQDNKADLIINYYVDDVLEKVMNILNIDIPTYNEDDNPIKRADTAIIDWTIDRRDVLSLEKRYKAKCKGVKKKRILIKNKRNSTEINSENGIIDDKTKIIKLELKEEQNGDVEVKPEPADMAMSNEQFQQLLSTITANKRGTFASCTFTYDGKKNSDAVEAFLAAATVFKSTEKISDSDALQSLPLLLRDEAAVWWQGTVGKKCSGVPCAAEHVTGRPCRGRLYDGVLDWEHSLPENDLTMAEWHSSIADLSICLGTTLQIVPSGNLPLETVKYDGKLVICNLQPTKHDNKADLIINYYVDDVLEKVMNILNIDIPTYNEDDNPIKRADTAIIDWTIDRRDVLSLEKRYKAKCKGVKKKRILIKNKRNSTEINSENGISDDKTKIIKLEIKEEQNGDVEVKPEPADVSVNGQCADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYT5</accession>
    <name>A0A835KYT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_014494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001072">
        <property type="protein sequence ID" value="KAF9404139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008036">
        <property type="entry name" value="PRK10768.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF15">
        <property type="entry name" value="NON-SPECIFIC RIBONUCLEOSIDE HYDROLASE RIHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9404139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="306" mass="33291" checksum="0987E3B30E26279F" modified="2021-09-29" version="1">MLEKKRPIIIDTDPGIDDAVALSIALNHPNLDVKLLTTVAGNVNVTKTTENTLKLVSFFEKQVPVAKGCDKPLLIQLEDSADIHGESGMDGYDFPVTSLKTLNVHAVEAMKECILNSAEPITLVPIAALTNIALLFSMYPETKRNIKEIVMMAGSLSRGNTNTSAEFNTYVDPHAAQIVFQSDIPLTMVGLDVTSTAVLTKNETEKIKGFGKVGKMFYSLFQHYRGGSLQTGLKMHDVCAIAYLTDPGLFTVQETFIEVALDGPAAGATVADLKMKYHDTTNAVVCLDIDVPAFQKWVVTNLEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYX4</accession>
    <name>A0A835KYX4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_012586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000478">
        <property type="protein sequence ID" value="KAF9407365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYX4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032571580" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9407365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57406" checksum="77B956271023C733" modified="2021-09-29" version="1">MNKWTLIILGLVFLSHVCAYKILVAFPYPGRSHSILGEGYVRHLLEAGHEVTYVTAHAYKKPHPNLRQVVVASVIDKFEFAQSLDFKKMLTKEADFKDMFAMYEIMAVIANRSLTHENVQKFLMDPNEKFDLVIAEWLYHHLYAGFAAIFNCPYIWSSSMEPHPVVLDLIDEVGNPAYFPDHMSPVSPPLTFTERVSELWYLIYLYRVLWFVRDMEEKAFRDSFGPAAAKRGITLPTLYDLKYNSSMMLANSHYSLGDPQRLPASYAAIGGYHIEDEIPPLPKDLQKIMDSATDGVILFSMGSMMRSETLPIEIQRELLDVFSKLKQTVIWKFDGSLENVPKNVHMVKWAPQPSILAHPNAKIFVTHGGLLSTTETIHYGVPIIGIPLFADQFLNVKRAIVKVLPWKYREKVKELSFIYHHRETKPGKTLVHWVEHVIETNGAPHLRSPALHVPVYQKLYLDLLALIVLGLLVVKRIFKRLFSSKNENKKKGEYKKNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZG0</accession>
    <name>A0A835KZG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000398">
        <property type="protein sequence ID" value="KAF9408221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9408221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="422" mass="47862" checksum="887E0ABF9E0C3F5D" modified="2021-09-29" version="1">MASKRINTFKVVFVSLAVVAVGFIIRTPWLPIRRELKASLGYPRDSLLNFTELTAEYGYVSEEHEVVTEDGYILTMFRIVQARNCHQRKRSPPVLLVHGLLQSSDSFIDSGPNAGLAYLISDACYDLWLGNVRGNYYSRGHTRLDPNKDPKYWKFYIDEIGYYDIPAMIDHVLDYTGNDKLNYIGFSQGSGTFLVMCSERPSYCEKVQLLIGLAPAARQFNTKSKLFRTLTQTFEVLEGPLENYGLVEVFSKGAVSQEFVAFFCQLSHFTGKLCEQVLDVFDYVDSSHLGSITNETTRVLFGHFPAGTSLHNMARYGQSMKSKRFEKFNYGKEKNLVIYGSEEPPRYNLSAVTAPVVCIYGSNDGLVDTKDVEWLVGKIPNVIESIKGEDPLWNHMDVTYSQYTSDTIFPKINEYLLKYTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZK1</accession>
    <name>A0A835KZK1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000699">
        <property type="protein sequence ID" value="KAF9405679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZK1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="22175" checksum="64FB8CD71B4A3E75" modified="2021-09-29" version="1">MNLYEPSTRRQVVQSMLVLVRCNTYARRMDIETVAAAAINLFCTYKYYLSVYRNRVIKKKWRRRRWWMLTIHRNRTKNSMENQFAELYAEPSGEFNNFVRMSSSDFEYLLQKISPTIAKKDTDWRDAIPVKVRLAVTLRYLATGDSYRSLHYLFKISSQVISIIVPEVCLALNNVLKDLVKLMPHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZZ1</accession>
    <name>A0A835KZZ1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000250">
        <property type="protein sequence ID" value="KAF9410712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZZ1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="155"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="286" mass="31273" checksum="7F637D7338B6F4CA" modified="2021-09-29" version="1">MISSAQRELGKGSPTNASATASPAGSVDNAIRSGVALDGPRPTPRTGPYFDLMASKNVTALLGKTAYLNCRVKNLGNKTLNMQVSWVRHRDIHLLTVGRYTYTSDQRFRAIHLPHSEDWTLQIKYPQHRDSGIYECQISTTPHMSHFIHLNVVEPTTEIIGGPDLYIDRGSTINLTCVVLYSPEPPAYIFWNHNDAIISYDSPRGGVSVVTEKGETTTSFLLIQQARPSDSGTYQCNPSNAQSKSIVVHVLNGEYPAAMQRGGQAFAPTSPTHCLVLAACLFITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0J3</accession>
    <name>A0A835L0J3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000488">
        <property type="protein sequence ID" value="KAF9407286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0J3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="78142" checksum="9C5F7696D2E7BDBC" modified="2021-09-29" version="1">MTVVLCVIMGKLSKHLKIAVALTASISLNSFKKKKTRIWVKEYLLLREKLSNMQILSVLEPSDLRNYLRVGVAEFEHLLKLVTPYIQKEDTLLRHSVSAKQRLVVTLRFLATGNSYQDLRHVSFARSDHRIRICVCILIFGLAPYQVLDASDLLRIRIFTIAMIAYQIAQFSFCSRSNMSSQLVEVYDNLAISCACFIVIHNILTSKPKQRRWWQTELFRNRYRLGGRALMRDLRFQHISGKYKNFTRMAPSDCEYLINLIGHKIKKTDTTYRKAISYYRSVYRHKVIKKKWRKRRWWMLTIHRNRTRSPEHKKPMYSDQVNFFEEFTKFFKGKDRESFLSSSMNNVIPEFDPLLREQTIDVWLNKVDECAEIYNWNDKQTAHFALPKLTGHAKTWYQGLPSIKHSWLEWKRILRESFPSTENYAELLTEMLNRRTRPGESLEVYYFSKINLLNRCKIFGKQAVDCIVFGIEDKGVRLSAQAGKFDKPEDTLEFFKTVKNYQPRDLLFRVFKRPIPLDVVKTSIITHSCLLLHNFLRKSKSSRNIYTPPGSTDSYDRNGELIRVGMRVNHEENLLPLQSVPRRPPINATQIRSNFMNYIHQSRLCSVSGDSYTSLQYLFRVSKQSISVIVPETCQAIVEALKDNIKLMSWIKSRKESSESIDELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1G7</accession>
    <name>A0A835L1G7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_011647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000360">
        <property type="protein sequence ID" value="KAF9408805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1G7"/>
    <dbReference type="OrthoDB" id="29444at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF9">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="16"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9408805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38821" checksum="63B969C6E756D343" modified="2021-09-29" version="1">MAMKEWLQWLPPPRSLLALLLAIAGFSGRLFASHFTHSPTLLVDTCHSLCRLVGLVTTLISYKYERADEGAGREGRLRNTFGWARIEVVGRLSVHVLFASFALALVVNALQLGVHSSHGQPPRYPKVIVGSAVIGLLLHAINYMLLAGRELSYSRRLSVTEGGGVVLKTGSGEPVLAHAPTDIASSLFVMGAGLTNEWEPVAARIADPALSACAAIVLVIFNYPFMRSAGLVLLQTVPEGLGTCDLRAAALRVPGVLAIHELHVWQMHRDKVVATAHVAYSSHEDYLKSSALVCDIFKRHGIGLVTLQPEFTLTSMLGTDEEKKALIDFANQGCSCPCAKECTAPRCCEPPRQPTVTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4E6</accession>
    <name>A0A835L4E6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Schwannomin interacting protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4E6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039045">
        <property type="entry name" value="SCHIP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015649">
        <property type="entry name" value="SCHIP_1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103:SF2">
        <property type="entry name" value="IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103">
        <property type="entry name" value="SCHWANNOMIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10148">
        <property type="entry name" value="SCHIP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schwannomin interacting protein 1 C-terminal" evidence="4">
        <location>
            <begin position="593"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="878" mass="100032" checksum="16A4245952247A34" modified="2021-09-29" version="1">MGEVGRFIKWVRAGLGVGLETRGFWPPPAPVRLSVPERRESSRSQYPIIMRIKTSDNGNIAVYNNQDVLSRRNSDNRSWLSVNNSAQTNLRDHTTDYSKVTNCNTVYNSQRKTDTFENYSTTSEVVADSGGLIVSPELVCNQQYRINNRHVNSVQTCDNTTTDILEESTDTVRAPCTGYTSNTNVYTETTPVDEERAFEHSDTDEMSENGIHPVPRGIVNPNYPGFPTLSAHNKSDSQQNIVDSQINNDIPDLLKTISKNNNNNDESFNYDINCTDADIENNFHAKDIIGDFNKEIEDEIKQLLNYNINIQDDLEELRKDIKDTFAKPIENTINNISDVVNHVIKKLVETQCDENDDIPKDNFEKQQNMDEISEVNKENEKNLRTEMNLSRPTFLLIENNTNDKITDAFLSDGKDEININDYNTEKLSLNVENTIKQLSTELRKIIPKLDEMRERDRLWAESKKETVVIDGNSNEVAHTSKGYSLMNKSVHSQGKSDPSQTMRLTDNHLSVRNNSIRSPVEPKAARDKQREITTSKNSYRTAQSKTSVRKNDNSKDVDLGSFDVYNIETALPKLDLDAIENHLKAAKEAERRKRNDREEIRRRLAMGADAEEFYSMGHTDRPGKKPSLHSRLQSGMNLQICFMNETASDNESQASDFEKNYNNTKSLSRSSLFSKSSYNHPYQTRPLSVNITKHDKISTVQSGAKLRPSPLSLKTKSRSSHSLGHIEIKESDFYVLQATLQTEARIALAQAKEMARIQMERERRSRAVSPVTEMLRRSMEKANAPLAPDRRRVSRQLLTDMNIAQLQVIVNELHSQIESLNDTLVKMLMARDELHMGQDSMLVDIEDLTRYLGVKEQTKKTKGTTKPAMRRLTSLVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4K2</accession>
    <name>A0A835L4K2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_008293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000157">
        <property type="protein sequence ID" value="KAF9413498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4K2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="294"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="684"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9413498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="84945" checksum="73CC6B31B3C5EF04" modified="2021-09-29" version="1" fragment="single">LREAFEAEAQEVKKPRLLLTAAVPVGPDNIKGGYDVPAVASYLDFINVMAYDFHGKWERETGHNAPLYAPSSDSEWRKQLSVDHAAHLWVKLGAPKEKLIIGMPTYGRTFTLSNPNNFKVNSPASGGGKAGEYTKEGGFLAYYEVCEILRNGGTYVWDDEMKVPYAINGDQWVGFDDEKSIRNKMRWIKDNGFGGAMVWTVDMDDFSGSVCGGDVKYPLIGAMREELRGISRGKDAQDVDWASVASSALIEVTEKPEPIKISLSDVLKRVKKPVKNVIIKNNNNAAIDKNRREPQILCYLTSWSSKRPSAGRFLPENVDPTLCTHIIYAFATLKDHKLTEGDEKDAEMYDKVVALREKNPNLKILLAIGGWAFGSTPFKELTSNVFRMNQFVYEAIEFLRDYQFNGLDVDWEYPRGADDRAAFVSLLKELRLAFEGEAKTSGQPRLLLSAAVPASFEAIAAGYDVPEISKYLDFINVMTYDFHGQWERQVGHNSPLFPLESATSYQKKLTVDYSAREWVRQGAPKEKLMIGMPTYGRSFTLINDTQFDIGAPASGGGAAGRFTNEAGFMSYYEICEFLREDNTTLVWDNEQMVPFAYRDDQWVGFDDERSLKTKMAWLKEEGFGGIMVWSVDMDDFRGSCGTGKYPLITAMKQELGDYKVRLEYDGPYESSNPNGQYTTKDPNEVVCEEEDGHISYHPDKADCTMYYMCEGERKHHMPCPQNLVFNYNENVCDWPENVEGCTHHTQAPARNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L588</accession>
    <name>A0A835L588_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L588"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038904">
        <property type="entry name" value="BRAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331:SF2">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="921" mass="106786" checksum="577B62F8128C613B" modified="2021-09-29" version="1">MEVSKYLKKFKLLLEYVFEGKVVLNENTTEKLLKLLEDRSDNSPGKLVLDTPCFSDLIFNSLESIHNATTSVKIFLFEIVTILFKNELQFAKIHGSIFTCILANLSTKNRGLNLASIKLATVQITHLSGLKLLLEHKVWQYILNDNTHRAPIRIANASYNFITKLILELNEYEMETELSEVLDYIVKPIISSSYHTLKIIDNETDTILSEKIYSYMYALLNVLKAMEDFPVNHVVQMLRSCFLVERSIFVIWKVTRYPALLKLSNDIIFVFYYSSHRHNLFNGKTQEFCNELVVFHHNSVQRCIKKREISVLVDYCIKCNIFWSKFEKTYKDKISFPLYFERNGIKFLASDQVFVFLVQPLLMCANEIKPGRTQDEKQEFIEKFLTKIGKTLTDHIFTLCYTYKPVIETQDLTETAIWTIREMYRLKDHLTQTQAGLYFTALYHMLDIYILLDGAGGLIVNNNPIKTPNDMRLLSLVLDAIRMLLKDYNISWYENVEIASLQEGLMNLLKQDILNTKQIVQVLDLIDLCMKKFLSPNMTLLVESRQESTLTVIGAVMKTYMHHDDWEVRDSALNLLLSCTDLSFIKYIPLQKVISENNLMIYAAKAALTDPEYYVQSTGLKCLASATKIDSIWKEVLIDNPHIYFQLVYILRNNPEGMVRKEATKVLTSAYKNQKLLPTFQSTLYEVMISAALDDLHWEVQLAALQFFKHEIANQLSQRGMIDGKFPSVTFSKEKRKIITLNDREILRQLTAIMHALSSIGCLTVLYECMNEMHHLEVMEQAYIMATELISILDQYKFVRIVDNALTYPMNSKNDDHDEEMALDLTIANNADAREKVIDSIVNTNQSELIMILHDNSFQTKSNEMEEDYSLCVQRKEIIHPNKFLETFKGTNFRAIIKEKKKWNSDVNHNLDGLLDEILDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5A6</accession>
    <name>A0A835L5A6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_010776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ced-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000282">
        <property type="protein sequence ID" value="KAF9410025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5A6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043277">
        <property type="term" value="P:apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000118">
        <property type="entry name" value="GULP PTB domain containing engulfment adaptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Q2</accession>
    <name>A0A835L5Q2_SPOEX</name>
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        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
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            <taxon>Amphipyrinae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="179"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2425"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2487"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2538"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2593"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2606"/>
            <end position="2615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2617"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2630"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2647"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2665"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2683"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2719"/>
            <end position="2728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2737"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2755"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2773"/>
            <end position="2782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2809"/>
            <end position="2818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2819"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2845"/>
            <end position="2861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2918"/>
            <end position="2933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2980"/>
            <end position="2989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2997"/>
            <end position="3007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3009"/>
            <end position="3026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="3224" mass="351273" checksum="4CE7FBFC01710DF2" modified="2021-09-29" version="1">MALGRGQMDRRRAAGALLALAACIACSAAAPTASNQTALDLYENAPEGCFYNFQHYGEGDRIMTNEPCLNCTCHNRMLMCYLRVCPFTKAIGQDCTVEKRDDQCCPIVTCPDVPVDLLTSTSTTSPAEYGATGIGKQDKYGCSINGRYFPEGSKVPPTPNKPCEHCYCIRNMTTCVMQECTLHVDGCTPIYHKDVCCPIRYSCDHEDEVPLLDDMTTTVRPTPGFLLTTTTMSPVTQMTQDCVHDDQIFSDGALIKTEKACQHCYCMKGDIVCVVQECGAPMENEGKNCTSLPPREGQCCPDTYICEGDELTSDLPTEPATDSMIEQLTTLSPPRRTGVEGSGYRNEPDEAPYTEMPTATELEGSGEEPEPEISKPLGPKDIITTPGDENQYIFSSTKAPDVTEDEKTTPEINKNIIPDEGEKTDESHGYGPTTSAPISEEIEKTTSKMTEEEISKQSTKAPEVQESTTDLGEEQNTVPDVIPEEEIGKPHEHVPSTTNAPVTSDTEADVDKDSKTPEKEPTIDSALDETLKETTTQSAAAETVSVKEQTESDITRTTPTSIEGSEGPIQEEKESSPPNEVTSEPTGSSDEEMKESSKPDEVTPETTSSSAEGEQASSKPDEYVPGSTSSPAEEEKESSKPDEYVPDTTSSPAEAEKESSKPNEYGFGTTSSIIEGEKESSKPEEYVPGTTSSPAEEEKESSKPDEYAPETTRRPGEDETEISPTDEYVPVTTSSPGEEEKEISKLDDVASGTTGSPVEEKKESSKPDEVTPETTSSPAVDEQASSKPDKYVPGSTSSPAEEEKDISKPDEYIPGTTSSPAEEEKEISKLDDVVSGITSSPVEGEQASSKPDEYVPGSTSSPVEGEQASSKPDEYVPGSTSSPVEGEQASSKPDEYVPGSTSSPAEEEKESPKPDEYAPTTTSSPTGEEKESSQPEELTTRTPLEEEHKLTTEPDHGENTVVIADEQSTPHSKPAMEQEPDTITKEDVVTPQEHFATESITKDSETTAEPDRGMNTIPGDINEDATKEPITTGHLDSMVTKGDQSTVTTEPSFRKEDEIASTEKSKEIGSTTIKPEFVDEGLIPTSAHDEKTVTSSDLPTIEDEFTTSVPEYVTEIVETLEPKQTTTESTKETSLVTEMLPEKSPEHDSAPTTSTEKSSEVSVGMVTHEESSRIPGEGDCLLNGVTYRNNSVVPSTNNCHTGCRCASSIIKCDPIICSPPPDYMDNCQSIYDSPDSCCPTFVCDHPRETVPPQSDNQMSGTESPMPSPTIECRGDQCELSEPTKQPTGPLEPCTSENCINEGDHKPDVECEAEGCKGIEHKPDVSEDCANGKCQLPQTDEQVSQQSCKPGEECKEVPSIVTPCEGELCNKIDCGPDGCDQSNIPPQPDKQPELCNEEEGCKPQDIPSSDCTGEEPCRRKEISGSGEKLPSTCEGPNCITEKETIVTEGLSDLSTESPKPEKSPTEEVLTISTTEKTGEEIEKEQSVTEDVSTKKSTTEEELATETPTPTEKNDLPTTGEGNQEKPYDKTEEGVSTSRPTVTDEYEKKPDITEREGTELPTTDSETDTEKSVIDESSTQKPAIDEEKDIDVPTVTDQESTDVPTVVNIETEKPSLTDDKEKPTDTEKDITEASVTTEKVNAGDDEGNVKPSDNEDDNQPDIDDRVREPELTDTKTTNKPAAETEGAEISDVTMQEITTKASVTNDEDKELTKTPIDQSEKDVETSTVIDKDGTDMEPTEKPGLEEEMKPHSEQPAIDKMPSEEDKNEIASVGDENTEKTATDSVLSVESSSTPASVEVQKGSEGPSITTDVTSEKPLYVDEDQDKPVSDKKEDEKKPIDRDGTELPAIDASTEKPYVGDEDNKETPIIDDINKKPTDGAQEDTIKPFIDGESTALPDFTEKESTGKPVIIDERTEEPVVIEKQTSKPVLEEGKDKPDIIEKSTEETTVSEMYTTRKPDHQLDGENQVKPVDESDTEKPILVEEKEKPVGDKEADKEKPVIIDEDITDQPNVADVNVTDKPKIHEEEGSGSEGLETTPATEIKMDEKLPETSVQTTEVAAVTEIDKITNAPVLDSQTTAADLNAETMDIGTSSESPINQVSDSEESKVTDGKETSQMPETATDSSLEPEVTTSSPEAVTITKQQEQEDSSSTVSQDLSSESLITKAPELHATSKPIGEEEDISTDSPDIELPSTKLPETGPVIIEPQEGFDTESPEIHVTVKPTEESATKDYEKNEDKLTPESHVTEASSALPELDTSDKEHHTTIETTHDDESKTQRPDLTSSEKEEMVTEPVTEPIRRFTEIEDPSVTGQGDVTTSYPEASTEHRLPFDTDKLEETDVGLPSSEKPIIMNETMQPEIPITKNPEYILEEDKEKPTINEFELPTTEKSLVTDSQEISHVPEEDTSSFEQTTAIPELSEHKHKDTTSFESETTQHPTEGLSKTSEYVTEPYQETSTKLDEKEVSHAQPGDDIEHETKVPEALPTESLDEDKKEPSVTEIEKQPTEQPLEEVNVQTEMPGVKVTSEVPESLVTEQKETINEQVTVSSVPQEESSQEPELMTTLFEEISKVPDVQDVHTEVPVHITESVEVSTIPSEQEKDYVTRKQDTDTTLQESPTATEKLEPAEVTKITEHTSPQTEYSETTPYLIELEEHTHKIVDDTTTVSPSDEEHSYKPVEDISIPTPADDEHSGKPVEESSTKSPSEEDHSNVPIEGVPTSSTAEEDHSYKPVEEGSTFIPSEEEHSLKPVEEVTTSLPTQEEHSYKPELEASTSSPSEGEHSYKPLEEGTSTSDTDEEHSDKPTEEVSTSSPSDEEHSYKPVEETSSFSPSTEDFTSKDHQDHITTALPSEEKLTTENQEGGREPEVTEFTTKLTDDVETQTKPSGVPQDVTEKAPESTPVAETTPAAAQDEDKYDADHKESTTSAPVQIAEETSTPAIATESEKLPSSESDNIAPTEKETSTTEKPSPPIVSQETTTPEEEILFSTTKATTIRQGDEVDDKFDKPDEKPIEASEIPPSSTTTESSKPSIPDLQSTDELPSPGEDEHFPPGTGPGGYGEPDYVEEDQAFGPGTCRYGGKVYVSAQQIPRDDPCDFCFCFRSDIICLQQSCPPPIHGCHEEPIQGFCCPRYECPVSMATTVNVTTTTTTTTTTLPPHFPTHSYKGAAQRRGCQIKGHTYKVGEVVRSSSGPCLHCTCGGDGQMKCDPKACTPEPMLRQMIAAAVSAKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6U1</accession>
    <name>A0A835L6U1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006254</name>
        <name evidence="1" type="ORF">HW555_009416</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000208">
        <property type="protein sequence ID" value="KAF9411942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6U1"/>
    <dbReference type="OrthoDB" id="8174264at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="173" mass="19784" checksum="6F6BF3C2CCFE9E23" modified="2021-09-29" version="1">MELTKVCYIGTLLSLLMFDILMEGSSQETSFELPVQLVGFPFIIVAVRLTNFVKKLSYALNPATYRSRNRRELTLGEPEPFDVNEVEKYIVGEFGARACVFERVCAHYATRAQAQPRPQFDWPDVFRQYKRSPDQAKEFYLLSVFLGDIVGSPQLCHQIGKRRSCDALAYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6U3</accession>
    <name>A0A835L6U3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000037">
        <property type="protein sequence ID" value="KAF9419939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6U3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9259" checksum="763289A4CB500936" modified="2021-09-29" version="1">MLFVRLLRAYQHVVVHGRCDVCDGPQPLQPEQRPLSLVSELSSRLGAHPARLQDARLPLPSSQDLEAIKKVAQILVTLGQQVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z7</accession>
    <name>A0A835L7Z7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Progestin and adipoQ receptor family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9423072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39809" checksum="08C4E9133571545D" modified="2021-09-29" version="1">MTLTMTKKLSECQAETVQFMPIEKVEDECRTEGYCQSSGLLRRGKKLEDNNNLTKEEEEYINYRQLLKYEQAPEYIKHNQYIRDGYRKLLPTKLCWESIFWWTNETMNIWTHIFGFFLLLFLTINDLVIINIHATVTDKIVAGLLFSCFLICMALSALYHTFSCRSEHDYNTFLMYDLFGIALSLLAIYTSGVYYAFWCHSELKTFYMTSVTVIFVVAMVLQIPRLGVPYLVKMCVFIGWAAYGVLPTLHWTYTMGGFENPMVQMFFPRVIGMYVISGTAFVIYAFKRWFPGKMDYIGHSHQWWHVLVLGALYYWHNSGMMYVQYRMNHGCANTMRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L835</accession>
    <name>A0A835L835_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_011754</name>
        <name evidence="17" type="ORF">HW555_003955</name>
        <name evidence="16" type="ORF">HW555_005048</name>
        <name evidence="15" type="ORF">HW555_005588</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000468">
        <property type="protein sequence ID" value="KAH9636918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L835"/>
    <dbReference type="SMR" id="A0A835L835"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9417274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9417903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9419677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9636918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="103" mass="11381" checksum="DF3EB26393BD208C" modified="2021-09-29" version="1">MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9H7</accession>
    <name>A0A835L9H7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_017353</name>
        <name evidence="16" type="ORF">HW555_003145</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000920">
        <property type="protein sequence ID" value="KAH9628278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9H7"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000007">
        <property type="entry name" value="Zinc transporter 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="39"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9420598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9628278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="38153" checksum="A7C7BC8B87B76A68" modified="2021-09-29" version="1">MLPLTQKDTRVPRGTVGGIREKIANWMRLIYSDKNSRNLFMFLLLNLSFAFVELFYGIWTNSLGLISDAFHMFFDCTGLVAGLAASLVSKWRANERYSYGYARAEVLAGFVNGLFLLFIAFFIMSEAVERAIEPPEVKHERLLLVSILGFLVNMVGIYAFHHGHGHGHGGHGHSHGGHGHSHNHHGHSHDDDTEAPTGAGSAIMRGVFLHVLADTLGSVGVIISAILMKTFGWMRADPICSMAIALLIAASVIPLVRDSAGVLMQRTPTSLERALPNLYTRVVGLAGVHAVHEPHFWTLCSDVHVGALKIEVAKEVDPRYVTEQTARIFREAGVKHLTVQLDYYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9W3</accession>
    <name>A0A835L9W3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9W3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="280" mass="32278" checksum="09AE69E3F326DFA9" modified="2021-09-29" version="1">MRLERDTKTNIKIPRPGQDGDVVILGPTEQSVKTARRRINMIVVSTRMKQKFTHFISIPMNDPDVQKRFEEFRERVLQECPCRGLERSLFILPSKLHLTVGVMCLMDNEERLFASKLLTEAKEKIILPILQGHLPLKIRLKGLSYMNDDPSQIDVLYGLVQEEGSSQGVIQQIADGLVQHFYRAGFMKDSEYERGNVKLHVTLINTRYREDPDDTNLENEETKSQNTKKRRETFDGRDVLQKFADYDFGTVEFTSVHLSQPRVALGADGYYPPTCIVSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA08</accession>
    <name>A0A835LA08_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_009177</name>
        <name evidence="13" type="ORF">HW555_002573</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000077">
        <property type="protein sequence ID" value="KAH9644602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA08"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="142"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9644602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="340" mass="37890" checksum="65F9010796A21338" modified="2021-09-29" version="1">MPDQTHMDFQLKWGVAGVGMIAHDFLTALGTLPADQHKVVAVAGKDIERVHRLATLHKINTAYEGYESLARDDSIDIVFVSVLNLQHYEITKLMLENGKHVLCEKPMGMTYKQTKSLVDLARERKLFLLEGMWSRFFPAYDALDQHISSGGLGDIYHISIQFGVEINDIERNLMKDLGGGAVLDLGIYMLQLVQFIYKDPPTDIVCTGHLSKAGVDESISCALKYKDGRTATVSAHTRANMTNKAEIVGTKGAITLDYFWCPTVLQISAANNTEWSLPKGKYKFHFHNSAGLSYEIQECWDCLSKGQLESPKMSLDETVLLSKLTDTMRAQVGVLEAELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAK5</accession>
    <name>A0A835LAK5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="794" mass="87583" checksum="C54699E204FC973F" modified="2021-09-29" version="1">MLAPVGPWARGSKQYAPATSFGITFAQMGNWLLPARVTLNHFIARPSAPRMLLPGHAVINERKRVDSNCRLTAVAIIGEVETVIDQGTVSSCRDQVKMTWLRVSACFLALSVLIAPTLAAVCPDGCVCNTTRDGLHRATCSSLSELYKFTLRQKHHNINILDLSHNNITKLNHELDRLTEVVTLDLSTNGIQTLNKFFHNAKKLVHLNLANNRIQKLSFVYLPSSVSSLDLTNNLLKDVPSDLGHLPSLEHLEMEGNPLDCSCENILARDRLLIANVYIDNVKCASPAKFEGKSWLELKTKDICKVPKTENNLLDMMMGDQPIDAVKIGEETTALKSMPLVAKSDLEDGTVIQGNDVVEDDDQLQFLKVGHTSPSPFNTIEGSGDGNDEHTTMIIFMEPKMNRKLEKDLLAADEVIAAETEPTTEDPIEGSGEGSGDILIGVDESHGYEETTTEPYVDLNPEPVHRYFDNDNNTGTEFPIPEPPSVYQGGVNWNVASPPEVTTEKVTSPTPRDTTMSEQIRVTQASEVYGQIRDENENPAPHKTGTYVCIAIIVILLVGLIGFAIIKGQMRKRRDRRLLRQQKRDVEKASKEMVDMNKSLLGKPAGGIEAPVDKKVNGKYELVPTHETPLKKTENGELGNGMNHSNNNGTRTDSPRDTNQNKNSSRDNNLVDDIPQQHETSFDSDPASPDSRKDTNSLSSEDIFVPINDDDNLKLNGTRDSDISQPLINGDQNTDSDFLSPSREYVPVYSPDMGRVRIKMTETPKPKTPVLVTRSRSNAGDIIITPADSPKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB00</accession>
    <name>A0A835LB00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_015343</name>
        <name evidence="14" type="ORF">HW555_000965</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000934">
        <property type="protein sequence ID" value="KAH9627899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB00"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9423907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9627899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="18304" checksum="0BF4E0ABE10206D6" modified="2021-09-29" version="1">MLMELTDDQEQSDSGMESLSASKDDSPERRPDEFFITPSLGSSPSAGTPIGGPTGGHLAGPLKEYDDEPDETLSERLWGLTEMFPECVRSCTYTFTTNTVSGVKSLYGLSRSVMWVIASSSVILFAPVIFEVERAQMAEMEKSQQKQVLLGTNTAMAGPMPNMPPMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBK7</accession>
    <name>A0A835LBK7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynein heavy chain 10, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="467"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="3">
        <location>
            <begin position="1638"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1744" mass="202570" checksum="54D190E4EC1B8616" modified="2021-09-29" version="1" fragment="single">MSTRNVHTLQELISQTESTEDEDIILDLYNDPRVKWFRDRILAFIGMDDEELFYNMLDYEDAKQKFINFLMSSIKFGEISLDKRMLYVSKVIVDKLIHEDKEFTEWRILPPVVANTQPQKGGKKGKGKGKEAKKPDTEDGKSAKGKNLKGVKSAKSKIDEILPSTGEADVETAAGAIGAGDEDDRLTKEDDGATAANDDKYYFPPPPENLDPDIDGTLEFYTVVRSVPRVIKYPKLIPIFGELTPQLAHRNRRYLYFLRQTQDPIPLSAKEMYTTLKMPDYFLTGVFTGKVLMSLGVHLKEATIPLFERQFREITLMSADSNHAVLSRQASYSGAHEQIIDAGSQVNYLRPSDYRRMSNIARGENAEKRMKNMHASPDESLNCSVGRSLNRSITDSTGFSNASFGDLGAPDTNEKTSADEVITDIKDLVAIVDWTIEHIEGEIQLPMPNIPMLHEVHTVEVVDPGLVSQLEEAVMMWQHHIDSTIAACLGKTREGDGPVAEYKYWRERDAEISLLVEQLKQPMVVKILNLLERANSKYLEEFKNYKEKLVDQYNMASDNLKFLSTLMRFFTVIEDESTLPQVLEILPELMESIYMMWVLSKGYRTDETMVPLLSRISWALSDKLENILNVHKLFDKPNEEVLSLARNSQKIMELWHHLYRETRRNIEISGKGARWEFDQPLLFTQTDYIGTVAKDLGDVVQVLIDFERIFGLELKSIISDPTQIDDVRKRVKNLVFPIRTIDFSVFVFDNKENWDVIMADFWNEVKYLEDEAKNYINQSFGNLRSSEEALSVLLKFLEFDTREAIRQQLSTKFDLVMRQFIKEITAIEDKFTRNRKNPPLLRNHPPVAGAIYWARALFNKMKQPIMKFQKVPELNDCEQKKEAFMQYKAFSKVIKEYEEQKYREWVGPAVQFVENMMKKNVLRVEFKKEPVVATTTGRGMELTAAGKAHLERKKKAAGSNVSLQPVDVVNKEIADKRRRDKALMLMRIPGQHYENVRSPSSTSLLAKEGLTDVTWRDLTVHKLMQEYQLSFQPNFDKHIFLVIHEAELLEQLGYDLPSTIRDVAMQKSRLYYELEALENVIAKYNTSTSSLSPSETHLMKKHLLDMERHILPGLTRVTWTALGIGDYINDITKGENSLQAVYKQLKMVEKEVQFLVDQLEAFDLFPLLKPKDYLDPKTGQPDPTWLYPCKAYFVEVENERLERIAVLSRMYDRIGPILMKLEYLILGTSTGTSSVMSAYYTHWEKKIFLCLVRLTLENLEDFQRMLSENMPMFQVDAVLVPPDITMRPTQTEVCNILGYNVKHFLNRLTTFTRWMKKTCLPCPPQRIEEATGNEFYTFSFFEDILRVAAINDITLLIQDTIFRLTSDICTYIVKWQKYSHLWSYDKHLSCEKYVQKYDQIFKYDEKFFFFEDIINDLDDHVKFVDIGAIRVNLRPVIQQIQDHAQEWKNILGDCIASNTRASMYDLKTQIEHLRMTVNMNIKGLEDFKLVMATITQVQLMTITAECKYKNMQEIFFMLRQHNINVPDEDLTFAKNLETAWGSLYQTTLFRASTLEKTKEKFSKMNVEEIAKFLRELDEFVEKFDAVGPGTVGDDMDRGIMLVEEYSKYFDEFDNRKKNLQAAEQLFDNPLADFSNFNRARTDFGFMEQIYKIYKAQKYAREIWSKTLWSNLNPQALVDGIEQFFKEFRKLPKPVRQTPSGQMLDLKMKQFKGVVPLMVSLKNEAMRERHWKELMRKTGEWHNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBY8</accession>
    <name>A0A835LBY8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032891065" evidence="2">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17105" checksum="0EC75908AF0DFDDD" modified="2021-09-29" version="1">MFNSGVVYCLILVVFLKNASAITDELKAHIEAKFLTVGAECIKEHPLTIEDLSAFKSRVFPDGENAGCFSACIFNKLGLFDDKGTLSHLTALENAKKVFENEEELENIEKFLTTCAKVNDEEVSDGEKGCERAKLAYNCFIQNYEQLGFDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LDA2</accession>
    <name>A0A835LDA2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EDR1/CTR1/ARMC3-like peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LDA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052441">
        <property type="entry name" value="Armadillo-Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EDR1/CTR1/ARMC3-like peptidase-like" evidence="3">
        <location>
            <begin position="533"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="661" mass="74066" checksum="C5C701B7FDACEC62" modified="2021-09-29" version="1">MKNSLDPDVQKNCLQTLSNLLEDPICAAEVTKNTQFSWPSLLALMQSKFLAIQHAALRTVDQLICRYKDQVVQKTFRTSTGVLDLCDILESYEFRDVHALVLGVLRNYVETEENASHLYQSGCILRLLAYLEMALPAMKPYCLAVLTKMSYTANGREALFNTETDMVFCHQLLSSSVELLADAAMGVANMTQLLASAVRMCDNTNIIDALCAILADESAVWFYIRLNALKAIVELCRVIPKAAFTVIEPKSFNAIRNVNRRFAQTPIEAQTLAVQCYINLEIYHVSKKAMINGDFIAELLAILQRPDISLKILTCTVLTGLMTEEVARDLFTLKKGEDVISKNLRIEHIGLSTALCAFIIASVSNEGADIYLDLGTIHYMVENRQARYVVSAWEPALEAIFRHHPSAKLAYTGRLDINDFTQEGFYCAKRLGDRFPSIKAVMSQTGRPRNPVFICLFQQPPHDPGSGTDVRSTPRLSEPKLSASSGRMRFASVPDDADLREYLLKLRLWFGDPARSLHYFEIEDAHYEVRLEKFNFLQSDLASPIIGLGYVKCGGPLERALLYKVLADRIGLPCALYRSSSAYAWCEVGVPEIDPEEDHEKVHNFPAGLLRSNYIVDLMQNPGRLIPRGGRDARKICGPVCSPPYTARKLPSVCRCEKKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835FZU4</accession>
    <name>A0A835FZU4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_014351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000995">
        <property type="protein sequence ID" value="KAF9404399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835FZU4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_uL5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_uL5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000585">
        <property type="entry name" value="PRK00010.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9404399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15712" checksum="AA5EFF1A260109B3" modified="2021-09-29" version="1">MGVGDAVSNAKNLDKAVEELGLITGQKPLITKAKKSIAGFRLREGMPIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVSKKAFDGRGNYTLGIKEQLIFPEVDYDLVDKVRGMDIVIVTTANTDEESRELLAQLGMPFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0W6</accession>
    <name>A0A835G0W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome activator Blm10 mid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000747">
        <property type="protein sequence ID" value="KAF9405402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="2">
        <location>
            <begin position="399"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1638"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1723" mass="194139" checksum="CABA905B46F43592" modified="2021-09-29" version="1">MIQDDEFEALVTTPERIKALGFKPQKEILTNHILPYAAELDDEASRFLQQVKTNLAKAVMLREMKPACGVWSSRLMKYIRIHGLKFSKEDHIKLIKLAYELVLIPDLEPCKIHKFATMFLMLTKKRQLISPDELTLHWRPLYDMGKKIFDKSATHIGMYHYLTHFSNGIYEKNRKNRKNRVPGAVLNLEPKEPVPKIGPRSMKQGGDMLDMIRKFLSGDGLGDALELFGLAGADENELPTSLEGSYISMVKCARPYFPLTATKEILAELLPQINPWSTDTHVVCQLAVFLPVAINPKYAQFGHELWFDEIMSLWDTCYNSQCGISDLMMLFAGLAKRNPGAIDWQPHVPKMFTRFLHALNLPVSYKDMQITRCHSLDMKHVASWIVWSIAPDGEVLKHLRSFLAGVESYLHSANSGRWSYKLRDLLRKLAREFLNRVRREREPKFKESWENQTPPHYRLKDEDITESCSSRHYRQCTAAAARSIYLLPLHNLATLRPAIVVPPLLERLKTSLTSLTEPHRVTAAMSAVAAVARPMLRGADAGYPEGPTHVVPFLLAVLPGLDPNDIKKTLVTLHFILIFTWMVPFIDCSSAHEHWSDLTEEELLTCESTAQLEDFVLVFLDRLFVIIESSVLEHVRLDTKESDAVRSKTDAVMETAISSAATAVLMQCSPKIFKEALRKFKAFATETTFETNVSGSMVGVMLHVFARIDSEATLAAFLPDLCEQLSELLATDEALHEENPSRDLVYRLVLLMHVVECDGVVLLKYVPDILPILDRALKLHSNYALSRACEVLSHMLTSLCYIDLKEWKSSPKDYGSAPETWLPIREWGYGCMLKDTNFKWHVPCEEEAKCAQMLVDRYLVAEAGRLEQWLAGERDMSRERRLRSFYIINALLACSTFLPPPDENPVSFLESHVPATSIPFTSGVRYQVTLGGENVRVALTRLLLKVQAKLLAEKTDDTKGLEMLIQVWERVVVMKGMRGGPGLEARLRSYGALERALDGRGGAPDRKGCPRGVGTARLRMLTADAARLHDDSRYDLVCEAGITPSALSALHALAELSINTYSSVRILAQIRLYWMLSHYPYSYRALVPKLAEILAKGGEGDEWHARHKGVLFMMLGPRSGPLVAKQDWDVVRTLWPAILNAPLSEKPSMVRLEQAFSDSLHRHFPTVNTRLTISNTAVDAAAVLITNEERSDPQFTKILNESIAREAANSDRTEKIYNELIVELMKVVETPNIQWRRLELAMQMLTFCPSLQTPYPGSAVRGMVQALLHDDIAVRRTAQRLVHYVLKQRKHKLIKIEIDPYEIAGVPRPEKRTPGYRKDLEWAIWSDEREHKTDEEWDQPWLRNSMFGFYAWPEKLEIAAPSSKQVFSSDLAPEAMEEGERHLYEFFNNEDNVNKLVAFLTVEEKKGKDKFNGVRFSLFKTLFAQFGNGVSARFLQHAERLTSVTPETLEDWGTCVATGVEKLDPTRGRQVIEGLVQICAPRSRTRDSEPDVDTSFSICARLYALQGALGSLRWRAAPLAAELLKRLEDANFTQHPYQNVRETVGSLLMTIFDTELVFPGGHNGDAPRLADFLATVQPRLAALYDENGDIVIKTAASAAMQCSPREAAGGCAPETSRLRPLPGVPAVGDVALDVARLTQTHDQRHTPPTDDTPQSTEAGESSDTEGEARAPRAERQLVSRLDAALRLTGDVAAPAPQDHARALNLLTTGNVTFFMHELKYISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3M1</accession>
    <name>A0A835G3M1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_013314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000621">
        <property type="protein sequence ID" value="KAF9406245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3M1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001329">
        <property type="entry name" value="INSM transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF10">
        <property type="entry name" value="NERVOUS FINGERS 2, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9406245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="431" mass="49258" checksum="8252CE57D649D35C" modified="2021-09-29" version="1">MEAALPHFHRLTSSRFYQQYAAPPVRISSNYLHDLIPQQHPTLLQQYLAYYNEPLVPLDLSLKSTTPITPPCTPPPLQKRKAVDDNKPDKSPKIFRHFEDNDTKEESQDKTDKRKIDDENSNDSDSPEVKKLKFTQQFFEELKTCLPQEEETTPSKSGRSSPDVVEIKDLEERPKKSPKPAQQPTKKSKAVRRLMFDEDKTSPVSGTIIRDLAEDETLVVRKGDIDPAFNVVEVTDEAKALIAAIENRLGRYICRLCRRLYSDAFALAQHRCSRIVHIEYRCPECDKVFNCPANLASHRRWHKPRVAGTVKRREPTAADSGRFPCQRCGKMFRRQAYLRKHMLAHEQPENEPEKEPSAFRQVHAEYPTYQPDVIRETGFNNFWNKIPAPQHELSWEGVRPRCGSSCSSEDSRSLDVTGSEDEGGGGGVMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4N9</accession>
    <name>A0A835G4N9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000655">
        <property type="protein sequence ID" value="KAF9405981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4N9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="193"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="604"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="665" mass="76976" checksum="3A8D07F8D40E3783" modified="2021-09-29" version="1">MSDILKDSRFTKYLNDPKYRQIPKHERKVKIDKRFQSMFNDEKFKVKYSVDKRGRPINETSTENLRKYYEVDDSEGSSASEDEPEKSPATDPVDKSEAEFVPGRFVKRPPSPSDDENVEKQTVFLNDKLVRGKLNKKVKNRLLDLDIDYARGEGVILTDSSSDEESSEAEEESDLEHEWGELDADAETTEESTKRIAICNMDWDNIKAVDLMVLLNSFVPPGGVIKKITIYPSEYGLERMKEEEVRGPIELTEKKIEDLSDDGGNEEGSSYHMEKLRRYQLNRLKYFYAVVECDSVSTADKLYSECDGMEYESSATRLDMRFIPDDVTFDQVPREECTKLPDLTKYRPRLFTTTALQQAKVELTWDATNPNRTETIKSALDGKIDDLDLKDYLASSSESEDIEKKDEKKSNKDMEMEISWGIGIKDKAEELVKKKLNEETKELTPFEKLIQKRKEKKKIKKLKNKDKKDNNKEDVSDSECGSLSDDVPSDIDMNDPYFAEEFNKPEFKKSKSHSKTKEQKNENNDIDLDEEKKKAELELLLDDDDGKAHFSLKKIQQSESDKKSKRKKKLKAKMIEHKQSVPDFEINVNDDRFSALYNSHLFNIDPSDPNFKKTKNMEKLIQEKLKRRPADTPPEAEPPKKSKEDIELGILVKNVKRKTKDVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Z2</accession>
    <name>A0A835G4Z2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000662">
        <property type="protein sequence ID" value="KAF9405925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Z2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032481930" evidence="2">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="393" mass="41786" checksum="4162170098774BC2" modified="2021-09-29" version="1">MNKLIVCCWLLVSASADLLDREWRFNPRDIQSVRDWRTLDTAKNSTSAPPTNGTTWAPPTNATTWAPPTNGTTWAPPTNGTTWAPPSNGTTWAPPTNGTTWSPPTNATTWAPPTNGTTWAPPSNGTTWAPPTNGTTWSPPTNATTWAPPTNGTTWAPPSNGTTWAPPTNGTTWSPPTNATTWAPPTNGTTWAPPTNGTTWAPPTNATTWAPLTNATTWAPPTNGTTWAPPTNATTWAPPTNATTWAPPTNGTTWAPPTNGTTWAPPTNGTTWSPPTNATTWAPPTNGTTWAPPTNATTWAPPTNGTTWAPPTNATTWAPPTNATTWAPPTNGTTWAPPTNGTTWAPPTNGTTWAPPTNGHNLGPTYQWHNLGTTYQWHNLGPTYQWHNLGTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5A6</accession>
    <name>A0A835G5A6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_011476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000345">
        <property type="protein sequence ID" value="KAF9409027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5A6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF73">
        <property type="entry name" value="RYAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9409027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="367" mass="41818" checksum="F0F065121B5A2CA7" modified="2021-09-29" version="1" fragment="single">MKTVTNYFIVNLAVGDILMTLFCVPFSFVPMLILRYWPFGFVMCKVVNYTQAVSVLVSAYTLLAISIDRYMAIMRPLRPRLGKAAAKMVVAAVWLGALTTAAPIAVVTQLQRPTPWHELCQADICFEQWEHTGQSGQYTCALLILQFALPLAALVCTYARIAHAVWGGRPPGEAQDARDSRLQHSKRKVLWTVHEEDERWATWPGMPYMWFACHWLAMSHSCYNPIIYCYMNNRYRRGFKQAFGCIFRKRLETSSRHRTSMYEGVQMSDAELIIVIDGSVKCSRFDDVTVTDCGGEWYDAAWNDEQLPQSVASCSHVFFVYVCEARVDHNPPAPRTIGTSSRLISSDPPKLTSRLAEMQLNEFYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5J3</accession>
    <name>A0A835G5J3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000426">
        <property type="protein sequence ID" value="KAF9407881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5J3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="299" mass="33063" checksum="B46BF2E06F11C569" modified="2021-09-29" version="1">MSQFPLFRLATLLARQLTVPFASKIKVLQPVHRGLQLHTRGLIKKLSIFGAQVLGPLVRVMCMQELAVNNPRFRRYVCVATGRVFHACQLRMRLWTLALRQPRVLPPISEQAALDSGAKILVFEVNRQANKQDDKVLEEASQWLALLLSLEELQRELELQQQDINRLQATLRRLAPTYFPRAPLDADQPMQHSSPKSKSATKSKPTAEFDAECPPSISSKYSPSPTLKSSPPPASECPAPPTSECLPPPTTECPPPSTTECPPPSTSECPPPSTSECPPPPPSECDCPPPPKRKCVCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5N5</accession>
    <name>A0A835G5N5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000473">
        <property type="protein sequence ID" value="KAF9407416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5N5"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="479" mass="55560" checksum="3B9F7E0EEC14B542" modified="2021-09-29" version="1">MVGNEEKDISQKNGFTNGILKNPSINSLDYLSNIMELDMSNGKIQNLDKNIELPSRLIHLNLSNNKLTEVPTNVLKLDNLKSLDISFNSIVFFDDIPSFCHSIEKLNLSNNCLNGPPLWVWTEKPINLKYLNISNNKDLCSTFTDSYLDELSQYKTLVNEIDIHNCRLGKHVKLLASFCHTKVITLGNEEYVHRLVNNLDHLPCVGLENCKDVEIMNLTNTQLFHIYPSIDIYTNLKELNLSQNNLNSLPNEFCKLVKLETFVMSYNRLLYLPDNMCELTNLVTLQLDNNKLCMLPENLLELPNLRILDLYNNNLYEGPSNVNLEEVDLAHNHFDEPDSEDYLMKKKKLRIGKLDRKDGRKVEEISEEWEKTSSSSDEEELNDLSNDKFIQDDQKDDRASSPEDWDSDEYWIPQYYKPPSPPQSPWLYFVKKKMKEGNFCPMDAHTISISELVKYDQLYNPHLVHSLDWNSDNYSDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5T1</accession>
    <name>A0A835G5T1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000524">
        <property type="protein sequence ID" value="KAF9406967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5T1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000095">
        <property type="entry name" value="Lactotransferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF29">
        <property type="entry name" value="TRANSFERRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032647241" description="Transferrin-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="4">
        <location>
            <begin position="43"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="4">
        <location>
            <begin position="479"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="863" mass="95193" checksum="D175E17867122ACD" modified="2021-09-29" version="1">MDTYLVVTLSSILIGTTSASIYGSENAINGINKVPKIEGQDIITWCTTSLLENQKCEKLAQSVLQDKGLFGKDFIELKCKRAFDTEECMSWVDRGEASLLGLDAGEVYVAGRYHSLVPILQELYGASKPYQYSIAVVRKGALPSIQPGYGLSGLRGAKACFPGVGALAGWVMPIHVLMQEGGLKITDCNNHVKSAIEFFGDSCAPNSLKDMYNPIGDNSDKLCKLCAGGAGIRCTLADPYAGYEGALRCLIANNSGDIAFVRDTTVQHALLSHQILGGVTEDQFEIICRDGSRRPVTDSENCNWGRVPADAIVTSSAVSMEHRKKYQDYLQVIYQLYGEPNPLNKIYNNITNGFQPGGYNPYSSTESSRYPYETFNRDNRFNNNFNNRQNEYEEDMNNKASTMPPFKNRVDSSGQPIESIFQLFRSNETTDLLLQDATVNFRVLKEEEQAAKHILNNKFVGGQAENAVLAIRDCPIKRATLCVTSDQEMDKCLKMRVALKAAFLSPTLVCWRGHSTRHCERAIAEGAADFALFDSADMLHAANMHRLVPFMQEIYSSGDNWYYAVAVAKEQDPDTDLTYLRGKNACHTGLGTAAGWVFPLAYLISNGWIRSYGCDGAHAAAEYFTKSCAPGALSAEYVDSGTVPHDNLCHLCHGASFRRCRRDASEDYFGHVGAVRCMVEGGGDVAFVRHSAPAEVSAGRRREWWARDLLPDDLQLLCPDGTRAKMHEYKHCNLGKVPGSVLMGRPNHTELDTYSNLMVYAQQFYGAVTTDEFSFSMFYSQPPYSDLIFSDVAVRLKPLAHNKRSAEIVAGPALIRAARIVSCDAPQASYYVASDPDFLSHAYSNGVMGHLLAISLFLLALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6B3</accession>
    <name>A0A835G6B3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_003647</name>
        <name evidence="2" type="ORF">HW555_013024</name>
        <name evidence="1" type="ORF">HW555_013077</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000570">
        <property type="protein sequence ID" value="KAF9406620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000561">
        <property type="protein sequence ID" value="KAF9406676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000425">
        <property type="protein sequence ID" value="KAH9637945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6B3"/>
    <dbReference type="OrthoDB" id="6991437at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027901">
        <property type="entry name" value="CFAP90"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15074">
        <property type="entry name" value="CFAP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9637945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="143" mass="16882" checksum="21669B50CCAC29F6" modified="2021-09-29" version="1">MKEEKDIDEKTLTTSLKLPDRLRTGMIIPTSEKTYFNTNWKPTAAPLCAYDMLYHPPDYNPKSARSDRQEPKIIRKNIWVQELQRRIPSTTHFVHGRPTWPILDRPTKQFVRIVVKNENPHMRINHILEWAEVSNQGLMSLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6C1</accession>
    <name>A0A835G6C1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6C1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="254" mass="29320" checksum="6D45160486B78DDB" modified="2021-09-29" version="1">MSLEVIPERANVTFLNPDYAVNVTMNIRRYSRKSPYYVNLMGANMQTWTNNITVDVKINQYLHNEYRPSFVGLHYRLCDLVNKEPFIGGAIKNSGLVCPLPAGMEVIPERANATFVNPKYTSNVTINIRRYSRRSRYYINLMGNTKQVWNNNITVDIKVNQYLHNEYRPSFITHHYKFCDLINKDEFIGGAIRNAGVVCPLPAGYHGVMNITAPTEHFPNVFPFEKGRLDFVVSLTSTQEPILKLYVEVRFKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6R6</accession>
    <name>A0A835G6R6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000382">
        <property type="protein sequence ID" value="KAF9408441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6R6"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="32"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="183" mass="20486" checksum="CB8EEA5514853CC9" modified="2021-09-29" version="1">MVEGGFPGQHTTTTTVTSSTTVQTNIRFDRSYLTTIPGILKIVQVLCSLLGFICIQCSRLSSWTKGSFFSWISMIAFWFTGILLGLYLFHILEKFYKIPWLKIEFLFCAIWTLMYLIVSILATTVHDNPHSAAAFFGFVAMLAYLVDAYLKFKAVRDGGLAQGSRVVSKQTSTVESPPPRVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7C4</accession>
    <name>A0A835G7C4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_011637</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000360">
        <property type="protein sequence ID" value="KAF9408795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7C4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19007">
        <property type="entry name" value="LGIC_ECD_GABAR_GRD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000065">
        <property type="entry name" value="GABA-gated ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000003">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit gamma-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="105"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="315"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9408795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="555" mass="63673" checksum="D803461F691BD97F" modified="2021-09-29" version="1">MAGILQVDAKGAIYLTTKNGTFPISLTSLKSRDDATSQHTPSILSATAKNLSHNTSETEHDYWDSSEMLLSNYINGTYDELEAFTLKQNAKRSINDAVSKNITMVLENLLKNYENSQLPTHGKGYPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDTRLSFLGPIRSLSLSIKMLERIWRPDTYFYNGKHSYVHTITVPNKLLRISQHGDILYSMRLTIKAKCPMELRNFPMDRQSCPLILGSYAYSNQQLVYQWQNSQSVNFVPGMTLSQFDLISFPYRNFTFTRREGEFSVLQVSFNLQRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVGLGITTVLTLSTISLDSRTDLPKVRYATALDWFLLMSFFYCIATLLEFAGVHYFTKVGSGEIVIDDAEWEELIEEVGGDAFAARQLAVRRRSSARSTTNFNFTLPAQSNQEESGAPGEQTAVRLTMERTTQTERRVPRWRQLLYCLAGDDRYRRQRQVEAGSRGHINSVSHIDRAARVMFPASFALLNLFYWMVYAFSSDDFAWSDNPMNTLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7L7</accession>
    <name>A0A835G7L7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000416">
        <property type="protein sequence ID" value="KAF9408001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7L7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="129" mass="15663" checksum="595A20A47FFB5392" modified="2021-09-29" version="1">MVDECWVKFQYRVKKVEHDAQRAAMFSGDSHHKFLLGHMISEDYLKRCDKATRGCGLSCETTPRVRRWRRLALDEIHRVRDDIPFTRRSYRDLVSHARRKLNHLKKQIIVRSKDAMEDYKYCITRRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7Z8</accession>
    <name>A0A835G7Z8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nervy</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_009920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7Z8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013289">
        <property type="entry name" value="CBFA2T1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014896">
        <property type="entry name" value="NHR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379">
        <property type="entry name" value="MTG8 ETO EIGHT TWENTY ONE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379:SF14">
        <property type="entry name" value="NERVY, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08788">
        <property type="entry name" value="NHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01875">
        <property type="entry name" value="ETOFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAFH" evidence="12">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="11">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9411206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57502" checksum="D7F8030ECB50B002" modified="2021-09-29" version="1" fragment="single">TTTSKEHRSPEQEEARSSPTPGPPSPLNNGTAALSSTESLSPPLAEGSRSAPALQRLRKFLSALQQFATDVGADTGERVRQLIHNLVSGTVNIEEFQAGVQECTNYPLRASVPGFLRALLPLAQRDLHARARRAKQTPLQYIRSHEHLILESGGDSSDIFAQHPSGTAAETGIKRRASDPFYDPPQTNGSHEDYPPQAKRAASSLFLNPSPFLYPLPSNASLFDYGHPYHTYHGNQEGGYERRDGGITVRDVNSMNAPFAEPRGLGAAPSGLLKTDDEWKNINTMLNCILSMVEKTKRALAILQQRGVEPTESNEIKRAASEIMATAVRQTEERVAEVRRRAEDAVNQVKRQALLELQRAVGAAETKALELVAAERGKVERLGERRHSPPPGRELSPNASSQQNCCWNCGRKAQETCSGCNAARYCGAFCQHKDWENHHQVCSGRDQKPTALRTSPPTTQPSLPKPLTRATTPIAAPTSSSATPLPDSRLSLTSLNSAERLLTTQERTDRLTLASLSSAQGLIGIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8D1</accession>
    <name>A0A835G8D1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000282">
        <property type="protein sequence ID" value="KAF9410020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8D1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="20459" checksum="49AE939A874608EB" modified="2021-09-29" version="1">MIQNHVTAIIRQILNLYLKLKPEWTDLSINFRQNGPSESLEPFNEYPCQFADELFGESDPGEGTSSQNRSRNEFEDRSYRDSHQIPEGENYYQLFQGLYNPVMAVSEIYFLENKSVRTSAMNSQYDGMGFDKQLALRRHQPDSSEDEFADDAKETAGKILNMYPRENRKRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8E0</accession>
    <name>A0A835G8E0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000223">
        <property type="protein sequence ID" value="KAF9411500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8E0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10871" checksum="3195685D80AFC9F9" modified="2021-09-29" version="1">MIALLNLGTSRNYLDNVRRNPSARCTASAVVGRSKTSLVTYRGPSNVRINRIVINSPIQANIYHSALDTNNMEIRITSNMDLSNPSEVKPQEWLWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Q5</accession>
    <name>A0A835G8Q5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methoprene-tolerant protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_004957</name>
        <name evidence="9" type="ORF">HW555_011811</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000377">
        <property type="protein sequence ID" value="KAF9408543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000894">
        <property type="protein sequence ID" value="KAH9628797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Q5"/>
    <dbReference type="SMR" id="A0A835G8Q5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9628797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60064" checksum="012A691F3F097364" modified="2021-09-29" version="1">MTSSGGPSTHLGMHSTMASQIGLHAPPSDFGLTVGVPAPTMGYEIQATHSGDSSSDSQSPGMPTAKASDRESRIIAEKQRRSQYNTQIGLIMSLLSDIVHSQRKVDKTSVLRLAANKLRNEHVFGDTIKCGHIETWSSSFLKFFDLFGGVMFGVTCRGRLFIVSPNVQEKLGYCHIDLLGQDMYNYVHPDDKETLRHHIYPQELQTSCDSRLFEHHHNFHIRIMRAGARSDPARYERCRIDGILRRSDKATSNGVQDEQIIRRQRVRTNRTFSSSGNDVVFIGMIHVLSSAMPARILPPTAYSEYWTRHLIDGRIVQCDQSISLAIGYMTEEVTGTSAFVFMHKDDVRWVICVLRQMYDESREFGESYYRLMSRSGHFIYMRTRGFLEIDRATKKVQSFVCVNSVIGEDYGCRMMEEMKRKYSVIIDVEKQQTEVAANDDVPVEHPKRLERIVMHLVEPSVNENIDELQLVPPSKENIISAIQNSEKVVQETGVRFDSRKRRKVDCDDTSEYLKRHSGLQDLNEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G970</accession>
    <name>A0A835G970_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000281">
        <property type="protein sequence ID" value="KAF9410049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G970"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20850" checksum="C30D04A8F24E888B" modified="2021-09-29" version="1" fragment="single">GCVHRNDYQQLEATVSRRLDGHQLALAQFGRGLLPYELPPSYSGSAPSFHGPPPPYDGPQLPYYEPPPPYYESAPPVLREAEPIRYEASRPYKLGSKLRKDIFYVLNWLEKHQKFFETKSSTDTGITDPEPTEAKYKYKTTPTDFEYEYYQKPNSYDNNSRQLTPHYLTLPSYNEFAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Z3</accession>
    <name>A0A835G9Z3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000226">
        <property type="protein sequence ID" value="KAF9411401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Z3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="96"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="502"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="841" mass="96620" checksum="8661FD078764E109" modified="2021-09-29" version="1">MVVLDCMHGLNRFMKNSVDISMSIKLIPVLLIIKLGLLRCSIVIDNWSQKSIIVSDYCPAFPYCREGAHTMCVHYNPNQVMGPKCRNGQNITITEELATQLLDITNAIRSKIANGKEKGKNGVLLPRGYGIFRLQWDNELATFAQVLANQCTLRHDFCRSTKRFPDPGQTVGLVRFSYPDWKIMAKKQDTPGLTEAKMSYAITVSLKNWYMQKVDVTEQMVKNIHSRNSRPSLLETINGGTTHMGCGLSAFSDFVFKNTSQIKNIYNSILVVCNYSARPQRGGESYTTEPPAPGLGYSPKCGCPPGSTEDQDCLCNLEPKTPEQKSPKKCNSLDGKGCEPTLVLLPIFTIEDAPDDLLFQRAESIKDPLKDFIIQRAKNNHHHDMVHSDDELEPPKIGPPPIPPRKSRKQVTKKSSIFTKAAQFKLPGSTNMVSPFVTAKKDVLPRKDFSNLNKKVDEYLQRQRFSFRRNDVHPKTVTPHLESPHTDAHVNEITTETILKTAEEEVMNLNQYLKEKKYLEENLDNRTLDMVLKDENDKDNKLLSLLNTLEKEVKHVALDGNEKELFDAKIRRIYGSIVGATDTTLVPIVTTNPYDSDNGEIDIGNLKSAGNHGLVNLTDDEKHPRFINKNGEHLEEDIQRGHTKNYDYLVHSRKEKLKNDLELKKYIKNLDENIFSDTESKHDVYDHNKYHNSYGHKYESDVDQKYIDDFENKYSEILDRNKFSDNNLDLKFDAKHKHFENDRKYRYDDNLDHKYEETLPLHRNTLKYENKDFNEFREVKHNSLTSIEDSAIKHSNLMKFKNGELHGGDRQLRRMRPSIPRARPKSDSIYIPQRARFIHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA09</accession>
    <name>A0A835GA09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF89">
        <property type="entry name" value="PEPTIDASE M14 CARBOXYPEPTIDASE A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="190"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9410955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="522" mass="59731" checksum="92E4D75EBDF46F19" modified="2021-09-29" version="1">MKTCQSIFSSIYNWIVESKSSWFDGSWFSEEVSSKRPVTTTTVRPLTTAPTSWFQTLLDTEDNDGAYVSNDVPIKKSAKKSLKKTYKGFQLLRTYPDVQWKVHEMLDLQEEAQGSGLMWWTPPSLNGSTDLLVPPDLLSDVKDHLKSNKIDYDIIIWDLQKAITYENPRLSKKQRLELEQLRGHPMTWRRYHRYADILRYLEYLQHSHSDLVELIPLGRSSEGLPLVAVKVSLSVNDTVIKGKEKKKWKLRSRMKPAVWVDGGAHAREWIAPAVATWMIHALVEGEKDLGAEYDLLKQADFYIMPVLNPDGYEHSHTHDRLWRKTRSRQPDHSDDYYVGWFPWNWGQTECVGVDADRNWDYHWSEKDSSLDPCSENYAGPHPFSEPETRAVSEFLSEHRGQIKLYLSLHAYSQAWLVPSSHSRESFSDDGVLTEMGKLATVALADLYGTKYQVGTAAEIRQPASGMSHDWAKARAGIKFSYHVDLRDSFGPYGFLLPGSQIVSTARETWQAVKAIVDNLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA95</accession>
    <name>A0A835GA95_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_010571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000268">
        <property type="protein sequence ID" value="KAF9410323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA95"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9410323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="865" mass="100693" checksum="9248299E1AF558C6" modified="2021-09-29" version="1">MSSDELHEEIVEIVEDDSFNFIAEDSDLTCTICQAEFLDPEDLNIHIDQVHKVKGTKKCYFCPEKYTDLMDFAEHFRDKHLANLFYCLYCLRSFKDEKEYKLHDKKHKRGTKSTYWCAMCSEKYGSLWDLRKHDLIFHEDNNEGYLIQNLLPYLSAVLKVKAVTALLSQHKPTVHTCMCCHYTTTELEDIITHSRNKKCKCYVCYMCTNVFKDKSSLQMHLEKVCEKRKPYGRVECPDCKVIYNSLVYSKHKKVCKIIKCSTCGTQYPSMYELSEHQSKDHPLSAELATCKFCWKHCVGTVALEKHMARAHKPYLHLYKYLCIYCKTPFKHPQKLFAHYFTTHRDLEPYTCTICSKTFRIRKRFTVHIKLQHKSVGFVEFDENYHVFFTEKKSEKPFIPKSLYGDESEKQTVVENTEDTDLTLLNMNSEISISETEGNQTETGLLVPRKRKKGTPKGRKKAQGTVTTLSSDDEPQEVPKKKTKPSRNTMTTSWKKKQQAINKKRFTCTICNKYCYTYQNYNHHISLHSKNEYKKCIKCSKVFRSKEKLNRHMNNEHSSSKLTDTLKTMLEKRKKGETMSDSLPMSEKFRRTIKKVECQDTGPVANIKQVEDGLSVQKFIENFMPETDNRSESPIDNTVIVKMVSGIEKEPVIKMTKFNFKPLSEATKLAMPVKFKSNQFERTLATVRLVQAVSMYQEDNQDNDSQSYNEEIDRNDSIPEVAEEVMLEGTEETPNSSQIPHKIVIPKLPTMYKDLKIAHLHPQAPYYKIVPVKDVLKATEKADVKKDTSKNTIKLPDGTKLITTNPLAHLIDNKEIEKVMEPMKNRYYKYKERDLPKMLVEALSNLDKPLVRKKKVIGDNYSEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAJ4</accession>
    <name>A0A835GAJ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000210">
        <property type="protein sequence ID" value="KAF9411842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAJ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="16514" checksum="171B123FB0D280D9" modified="2021-09-29" version="1">MFVYSNIRRYKSKPEALQSTVCVDILRANMFLSRASVVLLVAFLGTSWSTGGGVASASPLPQGIMNYNPYAAPPNGFMGGPGYYPQYPGLPNYSPQPRVVYVQAPRSSPPLIRTWDGIHDWAQNTVQSVLGQPAPNTDRNQNTGQPAYNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAP8</accession>
    <name>A0A835GAP8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAP8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="127" mass="14785" checksum="FA0BF9EA83C24B33" modified="2021-09-29" version="1">MSNVFPENLAQATIATYRTRLVYDKNDTNHRFAFKIKMKRNKIVAVHTSSSVRHVFRLFRFHSFSFSLSRSSSHSRRSDTRLKHFSSIYHTFGYIPFPHSAVLILYILNGLESIVSLLSTSQRTMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAQ7</accession>
    <name>A0A835GAQ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the insulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000222">
        <property type="protein sequence ID" value="KAF9411521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAQ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647:SF4">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032377069" description="Insulin-like domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="8">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="126" mass="13903" checksum="84D8BBD2768F8B37" modified="2021-09-29" version="1">MVKMNPQQSILLMALCAITLCSAHIGGGQVSFQDANPQVYCGRSLARALAFLCFEESGSESKRSESGSMYNAILSPYYKEQEGQYGWPWMAPHKARGMSLPSRGKRFVVNECCDKACSLSELLSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB13</accession>
    <name>A0A835GB13_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010477</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000263">
        <property type="protein sequence ID" value="KAF9410426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB13"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002972">
        <property type="entry name" value="GM18664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="341" mass="39675" checksum="6188F083EFFDDE7C" modified="2021-09-29" version="1">MGIAYHFKQTCESADIRLRQYLGLRIPSKYNDACVATDPFVPTHTTIIKKCKCKQQEPKRQTNYKKKSESEKMKRGPKPKPKQDHQCYQCDKQFRCQAQLEMHVRTHTGDKPFVCMYCPRRFTQKHNLTIHLRIHTGEKPFQCEVCSKRFSAQGNLHAHLKIHTGQRDHECSICNKSFITSSELTRHMNKHRGIRNFKCDLCGAAYVHSRDLKLHKLKKHQIVQQNSKIQNEGFNNSGNIDIIGIDVGKEPPMKDVGHLIPHLINEKPQQNLPVIPENQPLMPFEQKTKEMFHQYPTKVFEVHNCAICGEGFDYVTALAQHYLHQHKDHENIHSKIYGLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBM5</accession>
    <name>A0A835GBM5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="80"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9412246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="264" mass="30560" checksum="738A89CDFC019879" modified="2021-09-29" version="1">MARLVLMNNILLKSRKRELKQRRDERQMMRYTDKAFSMPENEFKANYRVSKDLYEEIYQNIKAFIPTPKRRSDIQPKYKICDADLKILSVDASFGGASHDSFVWNQHPIKQHLINLNNNGENVYLLGKYYYENSDSGYAQREYMMTPIVDAPAGSPEEYYTKLHCSARNTVERTIGVLKNRWRCLLGHRVLHYHPDVAAKIINACCVLHNMCINRIGFDENIANDGNENPDANSQEVNSTSAAELRQGIAKRAVLVQQLWASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCN3</accession>
    <name>A0A835GCN3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="18288" checksum="C5D753AF127491B1" modified="2021-09-29" version="1">MLTGEDLGKGTDRETLGGTDCIVAVWYFIAEELLIISSTARTKILEKASYISLMNKFCLVIGLNEFKMARLALRASLPLPSGSEDLNIPDHPHISRLPESFCGRSAVVVLLSCRSELSLGADNDLPKLLGLLSFPFGCNGDLSRLLTTDPTVRDCPGELPKQCPMHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCS2</accession>
    <name>A0A835GCS2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000217">
        <property type="protein sequence ID" value="KAF9411676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCS2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41803" checksum="5AB6E66530E4687D" modified="2021-09-29" version="1">MAEETYFELTKRTTTVTKNEIAHLSWHNPMLTVRKNKRLNFLEYSYNLECLDRNLDFLESSLVCPTTSPATEVCKADFLKSEMKNADFTDMLLDSAFWPHNEALTQEMTGITMCKWSPQEFLRSSSIVAVLNNIGGVEFFIKDKIVWKSILNLSPYIIKVLEHNKKPECFEELKESVYILETSAICWAPELNSDGSCCFVTAQKNGTLLFWQLFSTMDEPQLIGYVATNMEDMSVIRWIPKSSDTFFIIGTNLLGQIFAYDLKLENSGIKLIKTCCLWSHKDRMAAVALKYLKINDKTIFITSKHRHLLVQAIDNDGNIVSQYLNNINDHRISDIVYTSDDRNKSTTSEPDTLCWAVNANNKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDC8</accession>
    <name>A0A835GDC8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000154">
        <property type="protein sequence ID" value="KAF9413591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDC8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF309">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="956" mass="105534" checksum="20FC703E10FA9A44" modified="2021-09-29" version="1">MYRYNSFKMSAKDVHNVKKKYLSVPPDGGWGFLIVVAVAINISTSTAFTSSYELLLKELLKEIGSSSTNISLMRGLSAICTATAVILFNIGVICIIFVKSTFTFHICHGILQGLSFGIIYNLSCTILIDYFLKKRLMAIGLVYSVVAAVSMVAPLFIRWSLEKYGFRDTILLMSALTMHNFIAVALMQPVKWHMKRIEVSDKNNEKLLQSKKQKEDFCIVPIIKVTNTDGNLSNNNEKFYKTGEEICGINKVKSLLIDESLYEKFLKSCVCAGSALALFADTTYAIILPQALLIAGWLQEDVNLTQHLYGFGDLTTRVLFTLLSNWVQKLGSQELYVLGVTLGLVSRLGTLWSKSFIAKMVYIPLVGASHCAVTITIPLLVADAVSPEKFTSALGMLMMVTGLVNVVLGPAISAVRELSESYGPVFYLIASCLAIIVLFWSIELCYKRNKHKRGKSYRKVCHTYVVNSETMVSEEKKELSSLMEKKYKFVPPDGGWGYLVAISAIISFSTTTAFGGCFGMMYDDFISSVSLNSASVTLLMGIFSASVALAGFFTSALLNIMSMRKLAFVSSLIFACGTLGTVIMTTPIMFFLTAGMCQGAGLGVMFNLSCTIVNEYFSEKRVLVMSFVQTATGVIAMIAPIFVKWSLENYGSKGTLLLIGGISLNIFVAVLLMQPVQWHMKKVPIEATKKTELNNLLEVEANKEDRAETPILKLSELTDLECTTTKETLDKYFDIPEKGKKKSSIRKAIESVIDTSLIKTFLFSCSSFGPALSIAADGIYIVMVPPCLYSMGWSQESVAMAITLYGFGDLATRVLFTGISKWMYKIGIQKIYVIGMIWSNSQIVILVYFAFMGVAHCSIAVLSPLVIAEAVPPEKFTSAMGFYLLLFGVLSMSIGPAVGAIRDITNSYASAFYALISLYALICVLWPIEMIIKSRKQRRRVEKEDYGSSELKKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDK3</accession>
    <name>A0A835GDK3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDK3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="52037" checksum="5BE44D65A6359C45" modified="2021-09-29" version="1" fragment="single">RTIIKIREVQGPALVFKAHPYSFTNSEWSQFSSQECTMLNASSRILLFTPIIKCSVKHTAIICSFDCLKEKGAPQSVILKNQRRILSFLKYTSCPHAVPERTKIASTSVTQHRRNARCESIRKFLRCVEGARRFLRCDVASQFCVQAVTARRIPANRMVLAHCGLPQSSVLLEILHMMDVEEVAAKISSKNKHRFWIHPLLVTRHDGKEFNIFISNLKKFEDKFFGYTRMSVKSYEELLTKLYLNIRGQDTRFRMSISPEEKLIITISPIMEVEEAICVYLLLRKKERKKKRQYWVHPILRDRFTHGQFQTLYPKLSSFEPKFFHYLRMSINSFDELLEMMSKQIESNDTHMRSSVSPEEKLVITLRYYYEEKYSTRRKASCKAYNALAACRNAVCRCDRPQYIRSAVTARRIPANRMVLAHCGLPQSSVLLEILHMMDVEEVAAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDT7</accession>
    <name>A0A835GDT7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="334" mass="38528" checksum="4F99E8CE30F33EE8" modified="2021-09-29" version="1">MKFVKLSQTNDAMPTLGLGTWQAEPSVVKSTVYAALELGYRHIDTAFNYNNEEAIGSAITKWIDDGRGTRSELFITTKLPHIANRASDVEKFLNLQLKRLQMTYVDLYLIHVPFGFHCDPETLTPKVNEEGNYELDMDTDHVATWKKLEECQKSGLIRNIGLSNFNEEQIEKIVKHATFKPQVLQVELHAYFQQIELRKFCEKHNIILTAYAPLGSPGAKNHFVTKYKYSPSTFPDLLSLPDVTTLAKKYGKTPAQILLHFLVRQNIVVIPKSTNLERLKENMDFYDFELTTDEMDTLIRLDKGENGRIFNFLFWKGVEFHPEYPFESVKQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE17</accession>
    <name>A0A835GE17_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutaredoxin 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE17"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9412551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23051" checksum="5652F4821D1EE278" modified="2021-09-29" version="1">MPASWQTPVLTVVHFSADWAEQCKQVTEVLKELAKLPEVQSSGSKIAICDAEKLSEVSLQYKIDSVPTVILFRNGAQVDRVDGADAAQISSKVKAQSANKTALGDVAPVKLEDRLKALINRHDVMVFMKGNRDQPRCGFSKTLIQILNGTGVSYDTFDILTDEEVRQGLKEYSDWPTYPQLYVKGELIGGLDIIKELQSNGELEATLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEF8</accession>
    <name>A0A835GEF8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_008748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000176">
        <property type="protein sequence ID" value="KAF9412844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF3">
        <property type="entry name" value="ODORANT RECEPTOR 30A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="364" mass="42277" checksum="D63F155EA14EE34E" modified="2021-09-29" version="1">MDEKPEFTTFHETYKLITFALSVAILIASISPLATMIFIDMYKCWMANDIVNIIRHSTVVGPFLGGFFKMILMYHKRIQAKQILDEINRDYKNLNNYSEIYKEIGRASVKNCQIYSERGWAITVVTCVMTFPVMAISLNIYNFAFKSEPVKYMIHDLEKPFSDNPEARFESPYFEIIFVYMFYCSILYVVNFTGYDGFYGLAINHACLKMDLYCRALEEAFKADAEEVCGRVIGVIKEQCRMFQFVDLIQDTFNIWLGIIFLATMIQICTCLYHITEGYGFDLRYMIFVTGAVIHIYLPCRYAAKLKAMSLETANRFYSSGWEQVDDQRVRKMILFMVARAQVPNEIVALNMLAFDMELFVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEX9</accession>
    <name>A0A835GEX9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_004177</name>
        <name evidence="7" type="ORF">HW555_008478</name>
        <name evidence="6" type="ORF">HW555_013420</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000641">
        <property type="protein sequence ID" value="KAF9406086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000167">
        <property type="protein sequence ID" value="KAF9413198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000400">
        <property type="protein sequence ID" value="KAH9638375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEX9"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9413198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9638375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="30348" checksum="5639ABC5F2EACA80" modified="2021-09-29" version="1">MVQKKPKKKVGKKVAAAPLVVKKVEPKKIVNPLFEKRTKNFAIGQDIQPTRDLSRFVRWPKYIRIQRQKAVLQRRLKVPPPINQFTQTLDKTTAKGLFKILEKYRPETEAVRKERLKKAAEAKIAKKDEPPPKRPNTIRAGTNTVTKLVEKKKAQLVVIAHDVDPIELVLFLPALCRKMGVPYCIVKGKSRLGALVHRKTCTCVAITHVESGDRAAFSKVTEAIKTNFNERYEELRKHWGGGVLGNKSNARIAKLEKAKARELAQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF23</accession>
    <name>A0A835GF23_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="831" mass="94429" checksum="26792E5BF1F3DA5C" modified="2021-09-29" version="1">MIDSFFGFDTSLSNRIVQGFTAMWYYLIVNLMAMTRDNLNDDEGGGEPSEDEYDALNDETFGQGSDEFDWEVEHEQLAEQLESSRRHNSGIDDLANTQLEASLSQLVLDETDAPQSRTIGSSVWKHDPIFPSAPTPVQGLKNVCTVEELERQLRQKQAQPSYNQNYFQPRFPPVILQRPPGLQAPVPLPFAPQQPMSHNMNQMNQPLSKLMNQMGQNNQLMQNHVNQLNQGVTPFMNNQMSNQINNQFQNNPIGPGNNLMSQLSQNLNVHQMSNNQMMGQNIMPNGNQFGMNQFQHMMGQPRMMAPPPGINMQRQNFNSNMPQFNTNFRPSMPNKPEQQNMMMNQQMLVKNQQQPLNNIKNSTSNQLSQINQLNHVNQQQQQAKTIQKPVQKDQKLQKSRLIQNTHPMLQFNNSYHNANHHPMLNNRSNVFTNSQFNHPMFNQRVNGAYNNSKEKEGIKEAHKANQQNHPFYSGGVKQETHTHRERHNSNRHNSTSEDSATPRTYVPTQFENSLGKLQCGSVTAPRKIIDVEVVGADAAPSRVSRASSVASTTHPTEVPREMKRTKQLLLDIEALYLILLRLEELNDPLAISNALILKNIESVQRRPKQDSPKSESIDKRQVVNLAVNQKPAPSKNLLDEDKDELVNKMFAGLLHSDRIQQMLTVRKGRTLISRFVGRVPASHVRLRSLWGKLLRGLPAAARRDPNYLGPLAPHYRKSLHTVYVRLVTHPGFTLSCVCALMEKAAILVNTPEATSNERQWSKFLKTLARALKNTTLNVARPLQPISSNKLLLHMKQLDSRSTIEILQRGKTAEFADISKSEVTEQLLKHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFJ9</accession>
    <name>A0A835GFJ9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFJ9"/>
    <dbReference type="OrthoDB" id="5976811at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033067279" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="162" mass="18752" checksum="D923F234045EA2ED" modified="2021-09-29" version="1">MQSLVYLIFVAFSTCQAHYRGSYDSRNFITRDEPTIKGVLIECPVCDQTDHWMANTEECPIRNGSKTFKICKFGTYTNEVCGKRPDCFSGPGEQCTEKREFDMYGKKCAPGYYCNKMEGVCTGLEFQLDNNWQWKMFPFTGVRSELRNQPEDSKFSFEGIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG25</accession>
    <name>A0A835GG25_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_005941</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG25"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000010">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="33"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9416811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="940" mass="104278" checksum="D42EF974EC6F2BF4" modified="2021-09-29" version="1">MTAKIQTTFSLKLILKGPVRYLTTKQLVFSEFGDPSTVLKLEKCKLPDLGPKDVLVRMLAAPVNPADINTIQGKYPIKLKLPCIPGNEGVGIVEKVGSEVKKLCQGNKVILTMPTQGTWRTLAVFSSFALTAVPDALRVPEAATLAVNPCTSFRLLSDFIPVRGTDLIVIQNGANSSCGQNIIQLCKAWGVQNINIVRNRPEIDDLKKQLLSLGATHVLTEEEAKVTSLFKNKEIENPSLGLNCVGGQSSLLIAKYLKHSGCMVTYGGMSKKPVTIPTSAFIFKNVRLRGFWMTDWNKRAKNSAARDGMLSEIIQLMLKNKLKAPTHKHYAKTPMFSGSIRNLMSKQLVYSEFGDPINVVKIRESEVPHLGSQDVLVRMLAAPINPADINTIQGKYPVKLQLPCIPGNEGVGVIEKVGNHVKTLKPGNKVIVTKPVQGTWRNIGTFSQSSLMVVPDDIGLVEAATLTVNPCTAYRMLTDFQPVQKNGLVVIQNGANSACGQSVIQICKAWDVKNINIVRDRPQIDELKNHLYSLGATYVLTEEELRTTKIFKDKQIDKPMLALNCVGGKSSLEMLRHLQHSGSMVTYGGMSREPVTIPTSAFIFKNLSFFGFWMTAWNEMASTTAKEEMMSHLINLILEKKLKAPLHKLVKFDNYQEAIGKSPCLPSLPTIPGDEGVGEVVEVGKYVCRVKPGDRVVLSSRLLGSWRYYGIYKEREVHHISKKLPLPEAAMLTIAPCTAYRLLNDFRDMKHGETVIQNAANSACGQSVIQLCRARGINTFNIVASHCGYEAVKAYLLNLGATAVYTLEEAEELTAFDTSLARPVLALNCLGGRYEDVMLKLLERNGVIVYYGCGYDIPMAKQFLRCDAEFHKFHIHEWECDATCVEKDTMYKAITQQMVTGKFRAPVYQAVELKDYIYAFRNTVHCEAFATMNYVFDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH94</accession>
    <name>A0A835GH94_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH94"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="91028" checksum="7773210FDF5FB8F0" modified="2021-09-29" version="1">MYNLKACVVCFSANVKLISLNSCKLRQEFQIISGIKTRLEGGMPDYLCFQCAALVRKFIKFRSRCQRAHYALKEILNRNDEINETILSNFDRNLLDIMPPLSFMSPDKPRFEQVKFQWKKQNRIDWCNTAKNDIHVVHCSTLTADDTFNEVTNTEVLEFTEDKIKRDIDDVVQEQINIEYELPKNESQSFENNTNVDAEMADSLLDNDHMASDNEQDLTNLSMFKVESTAVDGSAMDEEYATIVPISVKEAKAVIEVYKMFTQGKYHCKVCNKAYNNEERMNIHLRMHDKHVSGNYHCGLCRYYYKTEFLLKTHMTEKHLYKYICRKCPEVSFDRTSAKQHYIWTHLQNGSKKDANWYESRPKWIKTRGGKRVKGVVTLKPVRKSSKLPDDFLIYSPIGHEEQYTLIQDRQKSRNYQEAKYQCHLCYRGFRLLRTYNKHMNKHDPAHAGPLQCDICKLHFKDQRKLYKHMNITHLFKKASTRLTHIRIKHPSMCLCTICGHSFVSDSGLYCHKQIAHTEEEIEQSNKMVVNTADPHYCHDCEIQFMSFAAFNTHLGSSYKHATTNLNHSQQAPKGGISQFYKAAASHEARGYSAARRPRRGVCSEIVNNGLTTSSTCEVCGKFLCNDVQARKHYEAEHPDTEYLKRYMCDVCGHTTRQYANLIVHMRTHTNEKPYGCPHCDRRFNMPSNRDRHLVVHTGEKRYQCQHCSRRFTQSSAVKLHIQTVHLKIPYAPWNKKNRKRRKELETAGMSTPLTLAPPPHKIAAYDAPADYLNAYITYNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHG2</accession>
    <name>A0A835GHG2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Hormone receptor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_006038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHG2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07168">
        <property type="entry name" value="NR_DBD_DHR4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000034">
        <property type="entry name" value="Hormone receptor 4, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032741262" description="Hormone receptor 4" evidence="12">
        <location>
            <begin position="17"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="271"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="438"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9416725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="74642" checksum="AA725ABD11F23EE2" modified="2021-09-29" version="1">MLFLMFYFVLPTGIMTLSRGPCDLDNMSLFQDLKLKRRKVDSRCSSDECSPANNKPDATPPQLSSVKLESTPEPPQPYRPRTLAPPPPGSHTSLSPGPWPPAACINGVKPELIGGHFPPQPLEPKPGARGSTQWRGTPAVIMGESGGVRTMFWTLPAPTSSGEPAASASHTPTPPTPDPATCSEESAARLLLNLGGELRRPRGPPLNMELLWAGDVSQLPAHQQLTALNLSAAAGSVAGASQVPGASALALPRPELRAYAPEAERDEDEQPMICMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGGCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHNKKAKAATTTSRASPPEKPKDPLPPIPSHLVNGTILKTALTNPSEVVHLRARLESAVSSSRDRAVPLERALHMIRALIDCDAMEDIATVRHLPDLLHDTSEIGDKLCKIGDSIVHKMVAWTKKLPFIMEIPMEIHSKLLMEKWHEISVLTTAAYQAMHGKHAHAPPSSDHEQDFMQEVNANLRTLQNCLTSLMGRPITLEQLRLDVGLVVEKMTQITCVFRRIQLRMEEYVCLKVYILLNQEVELEGIQERYVQVLRSYLEHAAPHHPGRLQELFARIPEIQAAANLLLESKMFYVPFVLNSAEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHG7</accession>
    <name>A0A835GHG7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHG7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032883415" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="20831" checksum="A68076AB8EA0EEDA" modified="2021-09-29" version="1">MSKLFVLFSAICFVTIGVKCLAEPLDDADIIQKEPDNLESDTEERSASPQAYNSVSNRLARPGLYPTQIRLVECYACVDCPTVLANTTTKYCPYTNDPTKNNKCVLYAEKYKQMERPWYIRGCASERGSCAEITRAESANARIVKLLHCSECDGDRCNINGVARSLPNLFAAILFVVVTPLMGKCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI57</accession>
    <name>A0A835GI57_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI57"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="93" mass="10688" checksum="85A4E298C96F8555" modified="2021-09-29" version="1">MELTFSMLEQQRVTTATDCETGFVVPRVRAHVFSAPQLVEDPSQPPPCIRFCFATHGEKGIVAYEAKHFKRREDVFLEFMNAIHKSVMSNTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GII5</accession>
    <name>A0A835GII5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_003967</name>
        <name evidence="12" type="ORF">HW555_004750</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000814">
        <property type="protein sequence ID" value="KAH9630676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GII5"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9630676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="148" mass="16870" checksum="1AB624D741BA4B99" modified="2021-09-29" version="1">MPKNKGKGGKNRRRGKNENETEKRELVFKEDGQEYAQVTKMLGNGRLEAMCFDGIKRLCHIRGKLRKKVWINQGDIILIGLRDYQDAKADVILKYTPDEARNLKTYGEFPETVRINETVVYSVDGLDEDIEFGDEVSSEDEADAVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GII8</accession>
    <name>A0A835GII8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GII8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="29156" checksum="8FA21D536764EDE6" modified="2021-09-29" version="1">MNTSVLLFSKKMISTRDLIELVRQKRCLWDRCHPSYRDKAAKDKSWHEIYLEFEPSYDTLNENKKTLIGNIITRKWYNVRDSYVKSRKPGVRRPYLYAEEMQFLDPIYLVGDRKSEKSFIEERISNDDDADNDNSHNWLQEVFVDIEEGGDTQAAVCPPKRAKVEYGTSKEENEENIVAVLANLIQKEEDEDRAFFKSITPSVKKLSESAKFEFRIQVMKLINSLKIRDRQVVNLKRERTSNVDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIZ3</accession>
    <name>A0A835GIZ3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000082">
        <property type="protein sequence ID" value="KAF9416886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="191" mass="22472" checksum="5961B000B77DCA68" modified="2021-09-29" version="1">MEDKNNPKSDDDDIQTIPLGDGLNIVRERKRRNFSKPEMPPSWGSRYRQLFHPAWMDYCDVYHCNDYHKPACGLNRKKMNFKWFQSMCHLILNNQCSTYRGFLKYDPVETKFCQAYVMFLRAGCPLTQDCPDELDPVCSMSLKDSHIVLFKNQCFMDAANCRNSTLQEYDEVFMDFCNRHGSKSNGRLRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ14</accession>
    <name>A0A835GJ14_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ14"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="198" mass="21791" checksum="70A96C35D33E7D39" modified="2021-09-29" version="1">MFSPVMDHLLNLRLGNILRNEVEVRALKDSRAFQQLLKLVLLETRAFNSTEISVTNSSCDLEACVITVRPERGTAKYTCEVSSEGPRFAVDKRSANMTLAVMPEYDPLITGLPTMVQVGEQALVNCTSDYSLPAATIDWFVDSEPQERQDSVKERALNCGEILLQKWSNGMKGDVVVISSGVSSPVTCIAGISKYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK01</accession>
    <name>A0A835GK01_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK01"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11421">
        <property type="entry name" value="bHLH_TS_ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000052">
        <property type="entry name" value="Protein atonal homolog 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032660">
        <property type="entry name" value="ATOH8_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF102">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="27295" checksum="8F8C043AA7F4822A" modified="2021-09-29" version="1">MPIRIDRILERDAGFVSGGDDDDSCSGPAHSDDSGVRLVETESRVKRPRTPTRLQPPKKRIRLNSREDLPSPESDTSASPFRPWSFTEEPQREPLSLVKKETSLLRQRRRPLEPPPPPIPPPPGPPRVPPHPGVVEPYQDKSKPREQRNYKNMTRERRIEANARERTRVHTISAAFDTLRRSVPAYSHNQKLSKLSVLRIACAYIAALSAAIDPEADLSSAVDHVTHTIHTEGKLRKKKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK68</accession>
    <name>A0A835GK68_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK68"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="73567" checksum="C0FB2B230C022862" modified="2021-09-29" version="1" fragment="single">MSKTARTMSTWYLLEVYLWFHKCKGSLSNSFRLQVTQYVVPAIDADNMKMSVVFTVAFECDTRLQAELFCYKAAQTHAMRAALLALLLAAAARGALLESSTTKVSAAAEEREAEQEDESDSAPFMIVVQHPGGRRCGGSLVSLRTALTSAACVRAGARPQRDLWALAPGTGALRRVARVALAAGAGADRAGAAWSGSAMDLAGDACAESAPGWPGLRDSALCLVGPTLCQSDWGAGVVCDGKLCGVLSRSARSADGSAEAVGADAAEAVDAAEAAAEAAAEARDASCGRTHVAMSVARWRRFLHCAHTLRACGGEAGGAAGDAAGDAGGGECAALCSEHRLLAGTEGEPSGGGGAAPGAPGTPDTSARAAKLPGKAAGATPPTRSTPPSRSTEPTLPESSQPSARPAFEFEPNRPDFKVNVRGQSETSSRAPQCCDRVFLGCTRANLTRVLEGGRVRRERRRLRRRGRAAAAEHGRDSGQHDGAAQLPGPAGGRHAGARLTRRCAPPQLRLNPFLSKLEVLRSHVPARSAAGRRRAAPRTCAPPRAPVYSVIKEELITIKTYGNNNRNKLYKTIIINYELDCTHDADGKIGKGYANVLRPSMSANTHDTRCTVLEQITLTSSASPSTLPSLRNPNTGSSARLDTGASSSSGGSHSSAASLGAAKRPVSSFWMLSIVFCMPWIRSCSRSCEPIPNWHKSPHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLC1</accession>
    <name>A0A835GLC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidative stress-responsive serine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Oxidative stress-responsive protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Peroxide-inducible transcript 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_004355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008494">
        <property type="entry name" value="DUF776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383:SF2">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="340" mass="38568" checksum="EA66BD0DB32B2202" modified="2021-09-29" version="1" fragment="single">RGAASDGLTTEALGLEDEDIFTNTTDRIESFFSVTVFELSVEELGVEFLYVYFLKFLYVFFIINADTWRLNFLAISSRRTHEKPNEYLSTFFYKTILRICFIPSSDDSQTSSSTSTFSRAGFPVAEIMDKEEAILGMVMGRLEIEPLKLNKIISNKNPFTSPLLKRNFMEVPLTFVPNESRCSCSSKKKLKSGILKKKHNKILKEPVLNILKKCSSAIKLESIDSCEDSTSRSLAEIERCDPLSLCTLVDNCNQLRISSSDYKLNLVANDECSGRRWWKHGVSSTQECREPKQQSSRSSSCSQQALNPPCDVTIDELASYFETLVHIPKKMSSMAEMMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLH3</accession>
    <name>A0A835GLH3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_016337</name>
        <name evidence="5" type="ORF">HW555_003405</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000240">
        <property type="protein sequence ID" value="KAH9641343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLH3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9641343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="197" mass="22753" checksum="2CDF27C11E302C65" modified="2021-09-29" version="1">MSMIPYFYDLERPFRMMERDFYRPDNFFGYSPFNQLMPRDFFGPSFFKPWENVFRPWENLMRPMEQLTSSMNQLALNEVSKITSDDEKFQVNVDVQHFAPEEINVKVVDGQVLIEGKHEEKQDDHGFVSRQFIRRYALPKGCLPDTVESKLSSDGVLTVTAPKVLALPSTGEKIVPITHTGPIKKQVGSPDLTKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM00</accession>
    <name>A0A835GM00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metaxin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM00"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03079">
        <property type="entry name" value="GST_N_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF38">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="125"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63826" checksum="DE59C3F6CA220DAB" modified="2021-09-29" version="1">MSTCNVREPQHTISGDWSSRSTKSPATTRSSSPSRGESIFHKYMDLIHSKSNLSVDANKAEPNERPFDFFDDEEFAFGINLLNNNVACVGDNITKLIQMAQEPWPDNVKLFQPYEVEQILLPDNASCLAVQAFLKMCNLPFEVEMRWNAEFMSPSGRVPFIKCGAFVVSELEPIVQFAANKGVSLCGKLSTEEKAEMRAYMSLITNVLVNAELYISWVDNETFNAVTKVRNSSVYPWPLGWLQTRAKRNAVIKRLKALHWYDKTIDQVLADVEQCCNSLSQRLGDRDYFFGNSPTPLDALVYGHMRAILMSSGVRAGALIKHITSSLLRHLLRCTKVTQMTLTTQEEYLVTQAFQVTRRRISPERTMSERSTRIKRSRMSIRNTSKDTIHSGSNKDVFGFKPFASKQIIIMTTKEGDDVSKNESTTKLDHAPIDSEISKSINEIIDDVLEKVDEVVIDEFAEKDDSDSERNDAFEIIAYPKTVIESKIDSIDVKVNDYLDTIEENDLTDTTNSLEIGLDDGMHIVNDDDYAHADDEVDKEILNNDPETRKSVVDDEITRFKSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM44</accession>
    <name>A0A835GM44_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM44"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="283" mass="30721" checksum="D9FB4EA9AC4586A2" modified="2021-09-29" version="1">MIVGDCAYTTCLILFRNNTLLLTKMMRGRGLLLLKRAMETTPEEMEPVQQSSVKPGVENTTVAASTDETSPKAASAYEASDREVPVSILSDHSDEEDLIDDSDADPTFVVPVKEISRPLVIPRRLSSSSSSSSSSDSSSSSSSSSSSSSSSDNDSNRPGPSTANIQGNSNDTPTNAPSTFSASDTAPSVSYPKISRKRIRNPAGWKSKIAKTLRNTGKENPNTVQSNQITGSTYQSGRKNVSKRKRTSVDDQFEKEMLNMFKENAKMMQNDDMSFFCSLLPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNF9</accession>
    <name>A0A835GNF9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_004347</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNF9"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024448">
        <property type="entry name" value="XylT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12529">
        <property type="entry name" value="Xylo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="21">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9419020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="900" mass="103311" checksum="99A3D61FEE783133" modified="2021-09-29" version="1">MAFLFRRYYYKYTKCLVITVLLAFFIHIFIAISLFPSINDNISMNSGYVSSARQLGGEVSARKNNNGFSDDEDLSSNNKNHNKLSTYLRLEELDFKPPCEIKSKEAISAIHRAKTQICKQQIVNKTCLIQSGSFYPQELPNSCRRGQNTYGKHLGCYADQKKLRLLTGFYGNYANTNSPSSCLDICIQAGFMYAGVQYASECFCGENLPQASAAVAEHLCDMKCPGNVTQHCGGYFTMNIYETGLSKFTPRVPTTASTMNEPIQIVFLLTLNGRALRQVHRLINVLYRSHHYFYIHVDKRQDYLHRKLSSLEQFPNVKLATTRFSTIWGGASLLKMLLASMKDFISLGWKWDFVINLSESDFPIKSLEELEKFLSANKGLNFVKSHGREVQRFIKKQGLDKTFIECDTHMWRVGERKLPRGIIIDGGSDWIALSPEFVSYVVGKQDQLLSGLDVIFQHTLLPAESFFHTVLRNSHFCDSYVDNNLHVTNWKRKLGCKCQYKHVVDWCGCSPNDFRTEDWPRIQNTQDRQLFFARKFEPIINQEIINRVEQYIGIKDHYLISNLEAYWQSIYNVEDMTASSDDILLTHAGSIVRHNARILLDEGCKIEPDLIIEINSYNYADVYKGNLILHKAIVHDNIEILIETWYKPKKHIELNFENPYIDNIKIFKVSSDYDQKETTFRNLAGILGPLSEPLLLYEFSAQVDKKSENFTLIWLDPTGAIGDVNMIHVDENNLTNFIKPNLKAPLLPGIWKVGLFEQNRIIVATKFLISPLEYFSGKDLSHQESSIIHSGSQNSYKNFSNIKPKNFLPDYEQSILLQKISQSNIQRIDQDLREWIDGLTLEFYNVLGSCIMFNNEIKDKLTCGRHKFENCVSTQWSSLTNDPKGTIGKLNTKTGQLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNM6</accession>
    <name>A0A835GNM6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032597625" description="Takeout" evidence="1">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26930" checksum="ECF9FD4FDA20B30D" modified="2021-09-29" version="1">MFKSQCLLLCLCYVIISAYGNAVPFIDKCEWKDKTCLKTSAQKAVPFFGNGLPEYGVKPLDPIHIDKVSLDESGLNLIFEDFKVSGPSKCKILNMERDEAPTYLKLEVETPIDVVGTYTASGQLLFVPIEGHGPFRVKTNNIYISAKVAVSTVDGSDGEKHWKIGKFEYTYEAKEKTLLEFKNLFNGDKTKAAPIEKILDENWSELMKLFAKPIISKIIHEIKDDIQSFVKAVPVKDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNZ8</accession>
    <name>A0A835GNZ8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNZ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="108" mass="12043" checksum="65F361087539FBA3" modified="2021-09-29" version="1">MNIIMYSNMQSRSARLVSAALRNDKGVGEWSPEPSTSGGVQHSVQASSSEHVVAPLSVLDTESDFDSDDSVLDKNYELPKVREKTAIQMGLTQKTLYHARSHYQQKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP34</accession>
    <name>A0A835GP34_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP34"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="28490" checksum="96245BA2D1128F2C" modified="2021-09-29" version="1">MQADQDVESSDYIHHSIMSECADKFGVTDHDYRTALTSGDVDAIDPCFWSCCFKGTGVFNAEGLYDLEATLPFIKTTFHDDNYKQVQKIATLCEKVNNEIINKGKAECVRAALLVSCFLEEGVVVSTRTANADQDVESSEYIHHSIMSECADKFGVTDHDYRTALTSGDVDAIDPCFWSCCFKGTGVFNAEGLYDLEATLPFIKTTFHDDNYKQVQKIATLCEKVNNEIVNKGEAECVRAALLVSCFLEEGGDRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPJ8</accession>
    <name>A0A835GPJ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPJ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="69591" checksum="93A8580FD23F985C" modified="2021-09-29" version="1">MVDLEMTLRQEAPPPLASPLLHDAVAGDSSPPLADEQFEDEFEDATDELPDATPDLHTAFNDCEVAIRKFFNNDLTGAMTIMKPWQRTSVYHSLGAAIFEFIPAMLTFDSSQINNALAALKIAIAICHEQRKNYTFVESIGTIIKKPNYAAYTDMEAHAELCYAETLMLQAAMTIMEGEDLTGFIKGTIKIKNCYNSYRECSKILDKKQWETEESKIQFQSGVRLGVATFNVMISLLPPKIISVLEFVGFSGNKSLGLAELEAGSRAPGMRSVLCDLTLLGYHLVICHFIGAIGDLPACERILHKQLKVFPESVWFLMFKGRIELIRGQFDTAIDTYNRAVSSQRDWRQFHHVCFWEIMWVNSLKMDWRESALYASRLLEESTWSRTIYSYSKAAMLLQLDDITVAEKKQCSELMRNASYYKQRIAGKSLPMEKFVIKRGARYQAQGGRLVLPAIELLCLWNMFQILAKNERDAQNVLKLIETTIERVENENREWMAGYEADNRALLRFLKGSCLAAMNLPRLALDTFDAVFHFKNDLKEDTFLLPYTLSEMAMCHYQLGDKDRALQMLQEARKKYSGYSLESRLHFRLHSKLDYIKNGSQGAIASHTGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQG5</accession>
    <name>A0A835GQG5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_017083</name>
        <name evidence="4" type="ORF">HW555_003264</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000312">
        <property type="protein sequence ID" value="KAH9639693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQG5"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9639693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13872" checksum="16AFE326F681DB84" modified="2021-09-29" version="1">MASLCRQIVRGNAFKSVLFSTARRGYADKMMPDPLEHATGMERKELLAMQAGNDDPFNMKVLKKAAGTRDNPTLVPSCFDARIVGCICEEHATAVTWLWLHKDHPRRCECGHWYKLIEKQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQN1</accession>
    <name>A0A835GQN1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diacylglycerol kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQN1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="6">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51631" checksum="8C65D3773E13E4DA" modified="2021-09-29" version="1" fragment="single">IDYEGFRWFLDTFLEVSAPDELSRHLFLSFVRRDRRPALREMAAASSTAACAAVTAHADHQGKLSLASKIHGLAERLQQLGKSSGDSVEGSDKGSRSRTGSVHPMFTVTTHPSYSSHELCLDRRNETSPSHSQMSRNSSRKSSNSLRVNQSTKIEDFRHLMRRSSTLEVHTARVSLKDIVCYLSLLEAGRPEDKLEFMFRLYDTDGNGVLDTNEMDCIVNQMMTVAEYLGWETSELRPILQDMMVEIDYDADGTVSLDEWKRGGMTTIPLLVLLGLDTNVKEDGEHAWRLKHFSRPAYCNLCLNMLVGLGKKGLCCICNCHGKCARCRKKIKGYNGITGLHCRWCHITLHNRCVGSAGGACSLGRHARHILPPTAIRPLVLDRQRSLPHRPQNDQQSLPTSISLPISIAASSEEKKEEREKREPRAPPISFQITPPDGSCPLLVFINPKSGGRQGSRVLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQW2</accession>
    <name>A0A835GQW2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQW2"/>
    <dbReference type="OrthoDB" id="16754at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="3">
        <location>
            <begin position="746"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="95824" checksum="ED4BAA1A8D16819E" modified="2021-09-29" version="1">MAKEMMIVFVYDTLCCTSEEDDPIDAVLYFHPGWVSDTQRHALAGQVVGAAHCVKTLFSQPVAITLQSGKFIIREYGRYILAIGSDRNIPDWVLKNRANLLTSMIKVYHGDLQVLAEQMEDQRRLSEKLYQVFETYLPVLQYGCHIFQRVPMLTLPKSATSVYMESMQILEHCRKSSGVLGGVVLYNNKIIATQLPPGLTSYLTVVDPYRIKSPAETLDTETPLPLGAQLLVVYVGKKLYDNLKKQVDKIQEFHQNGEEMIARFKKSQEVEREKQRDFPQSGMKRDKSLLFTAVPEEDHTMISPPSREERNPDEERKPPSMPDVVPFTNKPRQRPTKLSLSFKTQKSLDEDIQENEKVFTGQTSVCSTPMVEYKRLHGNMLSICQVPESQQDNINTELEPDVLKNIENCNKINLENEKRDNKMVLDINCIADHYINKPEPIRKLASVTDLQETIKKLSNRATSKFKLKRSKVSLNDDTPSPEHTPKNPGTMTINDPLFPVFRNDGVAISESLFNQYLEQHYSKMKQDSTDNMFTFNMKLCEQEKFEDFDSELNRSPQRTPKKIAKDSTKTLPTDQSRRKSLSLPLKSLNESTDSQIGSESEATSFKKKLTGVQLTPLMEKLSHLAFSDKSSGYSSRVMTPLELREFLTPAADRQITFTDRPKTQRQDSESDDDSDSDLELLPEYSKHAVKCALFVSGLHNMALLALLDTDAANNVETINTLWETSLNALGPIEQKCIEPLAAVGDATDYSYLTLDPDWGTVRKGGPWAALDIATMGLIHNEFAEDPEMSEFILRSDESVVVGSVCGGAQVYYQEKGPRGAGPPPPSDVLAAAPLRARRRLHRDHATLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRF8</accession>
    <name>A0A835GRF8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MBF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRF8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032307070" description="MBF2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12916" checksum="34A4929260CB4F4B" modified="2021-09-29" version="1">MYKYSSIAIILAVVVASECGHSFLGTNFLRPLVFHKEVRYPAKVLQKRIENFNFTLPAVPGVYSRSIQGILAYDLTHSGASANVTKGGLGYNFVNMRMKSDRYKELHYDIYIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRL6</accession>
    <name>A0A835GRL6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRL6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9423100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="73457" checksum="A93DDB288B79AF51" modified="2021-09-29" version="1">MHTFWFQTLKSTCDFIKTQLCTIAISLTLFNSVRLPKEAFRHGTVPYLVIYSFWLLAAGLPITLLQLAMGQLSQQDPVGVWRAVPILRGVGHLKVLTSYLCCVYYMMYVALSFAYLLWIGKGSFPLKDCTKLHITPNGYENKMNATECFSSTFLAPFTEYPQYLGIMAVLIFLLWFFVPALLYRLHKTLKTTLGTISVIIMAIAILLSTFLAKTAVLDSMFESCVQWSSLSQPYIWHSALVQAIMSTQIVSGYLTSAGGSVYRHSDVRWTSALIIMTNIFAGWLWVLLWESIGDTGRKDTSFISILVLIYQSSVSERRNKEWPILAFGVVFFSGIISVLILLYPVYDKLHRVTGDHWRVFACATSAVGTALTVAVLARGLEIATMLDELIIPVLAVFTSAVEVVGFVFIYGWCYLTVDIEFLTGSKLPNFWIATWWLTPVLIIGVTGWWLRALLRISWGNGNTLWPLLAVFLLILIVMVILAARAVAKEEQFNLFSKLVSAFRPSRLWGPEEPMARYVWMSQRYVHETVSIDNDTNSEPNHYANVMYSKNKYEEELYKNEIYPRTYSNIYHPNDDYKTDYLYDGGIKSIYSINTIPRGKKKSIDENYRSPNICIAKGRLGGPTECSCNRHFTLNVPNLRSNEVTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRN0</accession>
    <name>A0A835GRN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NDRG3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26951" checksum="93E5881214E42D1F" modified="2021-09-29" version="1">MDELANQLNYVLGHFGIKTFIGFGVGAGANILARFALVDALALINCTSSQAGWIEWAYQKMNSRSLKNRGMTQGVLDYLMWHHFGRFPEERNHDLTQMYRMYFTRNVNPTNLSLLIDAYVRRTDLGIARETDTIKVPVLNITGALSPHVDDTVTFNGRLNPNNSTWMKISDSAMVLEEQPAKISEAFRLFLQGEGYVAPLSPTKITAYRRLSDAGRRRPCRHSPVIRITENPISEAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUI8</accession>
    <name>A0A835GUI8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Elongin 15 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">SIII p15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_001159</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (CUL2 or CUL5), a catalytic subunit (RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1, ZYG11B or RAB40C. Interacts with TMF1. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUI8"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000016">
        <property type="entry name" value="Transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="17">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9423350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="154" mass="16271" checksum="C56A779B1921075A" modified="2021-09-29" version="1">MSEQQVASAPASAAVSAASVADEQRSSSGTVAGSTSGSAVGSTGPEEKLYGGCEGPNAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENEANEVNFREIPSHVLQKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUY3</accession>
    <name>A0A835GUY3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032471594" description="Zonadhesin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67852" checksum="9B46C70DEC13FBC1" modified="2021-09-29" version="1">MEVLVICLLLNSGEVNGQDILKDNLLEPLINELYLLYKDAYETEKTYVTRRFFTNFNHYTLHVEKLKEVNGWKHHNLKIESKAPWGEPVIYINNPVECRMPNAFITKEQFKKTMLDRIEKQKKEFSKDTIDLIRANKYFESHRPLPSYINENMNENIDQSIDKLNDEIVGVIGSHLKRHREVTNKKSTDTLMITSVSLKNGKINTNNRITSPYDYKNTVSISSRRSTPALKYTKEIKLKATSKSTPSSTHIKTPKKPNNLFKSYLLNPTTIKPNFNITTAKIPASKKQTKPVNKKLSSNLKLVWIPTLPERNKSIAKINTHKITNSTKKRAPKHTNAYVTVHHITGRSKKLSSNLKLVSIHEQNKAIAKINSLKITNSTKNSAPKHINTYDTVNHTKSTVMVNKTTRTVKATTKMVARDIIVIANETIKETTVKEPKLTTINIETIKKPEVDVTVHITESSPTVTKTNQTVKVTTKMILSDTENLENKTVNKDSIDETTVTKLKMNTTKTENVADDATVQHTKAITTEISTAPTVRVTNKTVVSDTTVAETKTTVTKTTTTIRRQFVRGEELRLQVLRVRPYVFMGDNSNAISMCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KX93</accession>
    <name>A0A835KX93_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_015098</name>
        <name evidence="9" type="ORF">HW555_013165</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000585">
        <property type="protein sequence ID" value="KAF9406486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000259">
        <property type="protein sequence ID" value="KAH9641002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KX93"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000019">
        <property type="entry name" value="Anaphase-promoting complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9641002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="181" mass="21118" checksum="0EBC67D21D8FDCAA" modified="2021-09-29" version="1">MASEKDPLVSERSGTVREVGNHAIWSLSSCKPGFGIDQLRDDCMETYWQSDGQLPHLVNIQFQRKTMVSHIYIYTDYKLDESYTPSRISIRAGTHFNDLQEIEVIELIEPSGWEMIPIKDIHDRPIRTYMIQIAVLSNHQNGRDTHMRQIKIHSPCEPTSFDINKFRNFSTVQFQQYATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ96</accession>
    <name>A0A835KZ96_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000812">
        <property type="protein sequence ID" value="KAF9405096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="149" mass="17007" checksum="D4A2F2DCE1F2568C" modified="2021-09-29" version="1" fragment="single">KSFISAYSSVSGEYKRLRTVRAPGDDSTWDIVRNTHLKLIKEKFTCFFDPQLGVAKLFTEDDDPTPEHIEMLLWAYSPEPKRVAKEFNFFENKDTPEEESEKDRISEGQDKSDASDKNVDSDEIGSKRPSGDRDGEGGSTPRRSKRIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZY9</accession>
    <name>A0A835KZY9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000605">
        <property type="protein sequence ID" value="KAF9406345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="37204" checksum="FB4512381071AB27" modified="2021-09-29" version="1">MIFSVNYTRPNSAAGSRRGRSRSRGPGGARSQSRSRSQSRNRSRSRQRRSNSRARSASRSRSQLRGLTPKGRAGLEEQSVMPQLVRGNRMNRGGMRGRLSRTNSNPNLQSNVHSRLGMTTRRGMNNIRRPLAVAKRGISKRGRGLSTANRYSAIGLRSDQILKERQNMLLRNNIIKSQTFTRSRNNSLSSPSQLTVSVANDFAKKRRNSVGNAGYLNKQSLAQLNNQFGGYNTRRGPGSVKSMGSNRSNRSSRSNRSIRSNTSRGSIRSRGRGRGGNRGVGRKFVNKQVLNAKLQKEIAVIQGKTYGTTATSEAPTGINFSPTPAATGQSLHQRFAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L070</accession>
    <name>A0A835L070_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000380">
        <property type="protein sequence ID" value="KAF9408473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L070"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47491" checksum="EFEEA2DA1C92E279" modified="2021-09-29" version="1">MSTSTIRKQRCQKLITMSTDKSSDMRSQTNSMSTEIEINEPTNYQGTVINKKPRSPLRNSRSQSRESRYPNNTTSLHRKVSTSPCMEVEQLCRKSRSPYMKSRSPNKETNSPCKETRSPRRQSRSSSSSSSSSSSSGTTNSTSSSSVCSSSASTGLSARRSSYDNADQCKISSTNKSVKEENAGQVKKLVLTEKKCESYTEPRPKLSNDAEFESDEIIENTPPRIIKKSTTNKDKVARTPGHAITKNLVSYSDSSSEDSDDNTQQPKDRNKTDLSKKEPNFVASGSTPLLEVANRTRPQVDFNSTPKYAISPIYTDESDVDLSDDDPTYVHTTNYGNKQKNFFISSPSRSLSSSCDSDVSNKEVKRGRKRIRDSSKWKQNKAKRLRNSGQPYTSVSKKEKRVPGRCLQPPCTEKCKLKCSNKYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0A5</accession>
    <name>A0A835L0A5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000309">
        <property type="protein sequence ID" value="KAF9409571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0A5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9662" checksum="38903C2313BC5E26" modified="2021-09-29" version="1">MDSKIIFKYMLSPSIEFIEIGDLVQLDLKYLCKLYYDLSTCIHLLEKGYGLQIFLSIWLMFTSGVVGVTVIVTNQVALKIACDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L181</accession>
    <name>A0A835L181_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L181"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="302" mass="33008" checksum="F2C3C83F1073081D" modified="2021-09-29" version="1">MDFSSHLMILTVGKIIFSQKNLKRLYTTATKMSTGENVGVPLQKVTAVLENFAPKQLSESWDNTGLLVQPYTPRNISKVLLTNDLTEDVALEANDQGCEMIISYHPPIFAPMKSVVQSAWKERIVSFLLEKRISLYSPHTSWDSVKGGVNDWLASAFEVEESKPIIPGTDPQVGAGRLLQLKSNISLTDAVSKVKQLTGLSHVRFALGKGKDMSSEIHTVALCAGSGSSVLKGVQAGLYLTGEMLHHDVLDAAQKGISVILTNHSDSERGFLMGFSKNFQNLLNNDVQVIVSQVDRDPLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1M8</accession>
    <name>A0A835L1M8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000340">
        <property type="protein sequence ID" value="KAF9409094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1M8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000034">
        <property type="entry name" value="glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="221" mass="24495" checksum="73E9CDB809A065B4" modified="2021-09-29" version="1">MALALYYTAGSAPCRLVLLVAAALNIQLDLNPVNLRAGEQFKPDFLKLNPQHTVPTLVDGDFSLWESRAISRYLVSKYGDKNNSLYPSDPQTRAVVDQRLDFDLGTLYPRFGQYFYPQIFAGAKADDALLKKLEEALVFLNTFLEGNKYAVGDKLTLADLSLVATVSTIDATGIVSLEKYPNVQKWFELVKSTAPGYEKANQAGIDEFKVLLASFKAKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L224</accession>
    <name>A0A835L224_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L224"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="246" mass="27596" checksum="E8BDFEBADF43EC2D" modified="2021-09-29" version="1">MAEQYSILSVLNSWEERVDKKMKAVEVQIQAAGPTKDTIARVADEFRTFRELVFDMLKLLRLQIGEHSQRLDDVEARSRRKALIIQGIAEVASEDCTDVTLGICNTKLGLNLTGASIKVCHRLGQQTSTDHHRPILVRFASIADKMKVWRAKTGLRGSKIAVKEFLTKSRQSVFVKARQHFGMRACWTHDGVIHIKDPEGGRHKMTTLDELNPLMTRYPKTQGTSPAVVKRPAAPLAVESLKGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2H2</accession>
    <name>A0A835L2H2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2H2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44575" checksum="09C05A2D11323852" modified="2021-09-29" version="1">MLRQNIKKEHESLLISFVLKTRISRHAKLRLASNYDTSADLIKDMKNNLLTKQSATALQLELLQSRQGSQSIEEFGKKLEDLFVELTISQADGKEDAYKMFRPVNEKLAIQRFTEGLRNGRLSTILTARDYSELKDVIRAAKDEERAHQGHSTSAETVFAAQHRGRHRNRLRGIRYLLGLITEGAQEVLLTIREDVDYHQGVGGGREARRRSGLTFRGGGCMLMLVAGPSATETRDHEELADRCRHTDASPPSAAAERVRSPYETTPRMTRVHPYHDKRTIKVKLCTIEVLWGITASSPQTRRRRRLLTVLTEVIDFSIEILILSCSEIANPAVNCVTIQTKCLFQVLELLLLFIFCYPTPLSQRFSVVTIAILSIKGGNLGFLKNCVRYVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2H8</accession>
    <name>A0A835L2H8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2H8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9429" checksum="0890B2601FDFADA4" modified="2021-09-29" version="1">MSCGRRGRRCHGKFHNQSLQLSLHFTLQNENIEGNCALWWCFKFLDLTRKLHGRANSACTLRDGGVTTTSVPGESAGAHDLIDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2Z8</accession>
    <name>A0A835L2Z8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HW555_007095</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">BAW_Kor-Di-RS1</strain>
            <tissue evidence="27">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2Z8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="180"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAF9415219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1039" mass="108866" checksum="F0C3F46D4F96420E" modified="2021-09-29" version="1">MSGSVRLLCIRKPLQRSWHYRLSSSSATAPPTPGIPYSKLSVGIPKEIWENEKRVAVVPAVVSKLVKKGFSVNIEENAGALANFPNKSYEEAGAKVTSLKDTFQSDIILKTMKYKVLDPKGRLYHFYILHKIRNLIKKLANKNVNAFAMDCVPRISRAQAFDALSSMANVAGYRAVIEAAAHFPRFFSGQMTAAGRVPPCRVLVVGGGVAGLAAAAQARCMGAAVRAFDTRPAVREQIESLGAQFITMDMKEEGAGAGGYAKEMSQEFLDAERALLGKEARTSDVVITTALIPGKPAPVLILEDAVRDMAPGSVIVDLAAEMGGNVQTTKKGEISKIHGVTHIGLTDMPSRMPAHASTLYANNISGFLFSLGTNDHFHINLEDEVTRGAIVLKAGELLWPAPPPPSMAAVQASSPTPTAVAKPEPPNPFNETLKDAFLIGWADWFGIAAPNPAFTTMTTTLALSGVVGYHTVWGVVPALHSPLMSVTNAVSGITAVGGLLLMGGGYLPETPVQWLASTAALISFVNVFGGFLVTQRMLDMFKRPNDPPEYGYLYGIPAAALLGGYITAAMQGYSEVHQIAYLASSLCCVGALAGLSSQTTARKGNYLGMIGVSGGIAATLGMLTPSHPVLAQMLGVAGIGGIIGSTIAKKIEITDLPQLVAGFHSLVGMAAVLTCLATYMHDFPAMAMDPTAATLKTSLFLGTYIGGITFTGSLVAYGKLQGSLSSAPLMLPGRHAINAGLLAGSLGCGGALLAFPDLPGLPLLSAAAVLSGIQGLTLTAAIGGADMPVVITVLNSYSGWALCAEGFMLNNSLMTIVGALIGSSGAILSYIMCKAMNRSLPNVILGGYGVTSSGSARPAGATHTEVTVDSAADLIHRASNIIITPGYGLCVAKAQYPIAELVDILKGIGKKVRFAIHPVAGRMPGQLNVLLAEAGVPYDDVFEMEEINDDFPETDLVLVIGANDTVNSAAETDPQSPIAGMPVLKVWKANQVVVMKRSMGVGYAAVDNPIFYNNNTAMLLGDAKKTCDALLDRIKHLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L331</accession>
    <name>A0A835L331_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_006960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L331"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="289" mass="33918" checksum="DADF57B6B209A766" modified="2021-09-29" version="1">MTQQKKIPKIKKIKEELNKEFTFLKNVFSVMALPLQMKGENDDNMDIEIVNDNPKSNEDVEMPKRARSIAELEEKLEKIKSQNKFSFKNKLQKKSLTSKLNKKIKKTERVKAKVKPVVDKPFADMLKASVEEKPKPNIAKPVFNNEGKLVFSKFDFANVGKKERPNKAEKDPKKILENLKQQEERLKQLEEKEDSNKVKEIKEKIAWKNVLQKAEGQKVKDDPILLKKTIKKMDQKKKQSKKQWDTRVQNVEQKKTERQKKRSENIAKKKKEKKSKIIKTSIKRGRVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3G4</accession>
    <name>A0A835L3G4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3G4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000002">
        <property type="entry name" value="Erythrocyte membrane protein band 4.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF52">
        <property type="entry name" value="HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="3">
        <location>
            <begin position="543"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="978" mass="112228" checksum="C838D1FE49450A87" modified="2021-09-29" version="1">MSMVRRSSMDRMSSSMTSSMTGMGLGGITGLTSGMSTLSCMREQQMTIGGMPSNYVPGLSAYYNISSFCQRPGQTRRWPMQRAGPTAQHRPGRSHSTGSLHRMKYSMRNSPNTQYTHNLICKMADQNERRRRQDTMEMIPQSYYSQQPLKVELTEFYSRDNSKDHHTEQYDLVNDNILPNPVLRRGQNFFFAVRFDRTYDKQQDMIRIVFCFGPKPSVTKGTRVVLPVNWSNQQGVFQHSRDMMGMGLGMGMSRMQDTSTSMAPMGTMSTMGNMGAMGSMGTMGSMGPMSGMRETTTYGVRRSSFSNEPLPLQHSPLSPHGPMDRPMMDRYGGTGQHSTFGRGYGSRHGSMQNLAALAHDMDRWDISIQRQDGNTITFQVHVPATAPVGVWNCWVQTNRFGQRDNRHDYKCDEDIYMLFNPWCREDPVYMDNESSRKEYVLNEQGKIWCGTWRQPKGRKWIYGQFDDVVLPACMYLLERSGLEHSERGNPIRVCRAISSMINANHDDDGLMVGRYDGEYKDGVAPHAWTGSVAIMERYLTDGGRPVEYGQCWVYSGLVVTICRALGIPCRSVTNYVSAHDTNRTFTVDKYFDRDGNEVPNGPDEDCYDSCWNFHVWNDVWMQRPDLPQGYSGWQIIDSTPQEEAEAVYHCGPASVEAVRRGEVGFQYDTPFMYCQLNAELCHFQEEENSEWGFIRMASNQYQVGRKILTKNPNRDDDEGDSDMLEITHEYKTVDSSSPERLAVIASCRGYQRLQQYYEYPDRNFEDVYFDLMDIDLVPYGQPFDCTMNIQNKSHEDRTIWCVLTASSCYYTGAIASRLRRAQGEFIVRAGQREVLKLHVTPQEYMDKLVDHSMVKVHAMAYVKQTRQAWSDEDDFPLHKPRMQVQVVRSQPCIGQECAVTFSFQNPLNVHLTDCYFTFEGPGVQRPRQIRFRDVKPGEFVNYQDKFVPRRHGERRIVVTFSSRQLDEIFGCTTVNVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3J4</accession>
    <name>A0A835L3J4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit MIC13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MICOS complex subunit Mic13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3J4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026769">
        <property type="entry name" value="Mic13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15884">
        <property type="entry name" value="QIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="208" mass="24046" checksum="D08D0415F9F8CAA4" modified="2021-09-29" version="1">MTSPPRCQEPDRVKCDVCRTINLARHVKHPKPDMQMYEKCTPAEKFCVRGDPPLHPTCIKVCTKEEYKMKKSGQSVVIPRKPHYAHGKLLYAVKAGIVVGSLYFTYTQGVWGDQRQVTECIRRWQEYFRSINTRRPPIFDKCGNVIKKDTVESLLGPLYSAYKSAVTTCFAGVVKVPLMIKCAYFDYLKALERKHEELVKERKLKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3L5</accession>
    <name>A0A835L3L5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3L5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="23061" checksum="10F3308DC01A1D6F" modified="2021-09-29" version="1">MTTPNFLIEQVRAERLSDIERTFDEIAALVDRYETANYDLGMVAGRQMSTTSGEFIVQHIEKEIMSYINEQIAILPDPDLKKKKAKPEEVAMIKDILETFLDENIDAIVTEVEEIEEEEAPIPDIVVVYAVPGIGPPVDNETMADFEEYIREVSKVQADMVMPRNIRHFLCPPLEKYINQDYEQKEQTHTTDEVPVGGTIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3N0</accession>
    <name>A0A835L3N0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000446">
        <property type="protein sequence ID" value="KAF9407679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3N0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9407679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="15573" checksum="A96EC4F9FCF361CF" modified="2021-09-29" version="1" fragment="single">ESPCTGPNEYFACDGVCQRSCAALGVACPIPHVNCTDRCYCNPGFARNATGTCIPISQCGFPRPAKRQASPGAAPPVSTQVGQRPLSGPVPTVPSACCSNMSSDTERLAAHRYTRPRRAFELTDFRWIVTGGIRPLQATSDATVPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L433</accession>
    <name>A0A835L433_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008820</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000179">
        <property type="protein sequence ID" value="KAF9412735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L433"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF84">
        <property type="entry name" value="CYTOCHROME P450 28A5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="495" mass="57312" checksum="DD98564A5B0D0DE7" modified="2021-09-29" version="1">MLSTAILAITIVVLILTYLRGKYNEYYWKKRGAAFYKRNKTFGPLWEYMIGERPLFQVFNELYWRYEKEPAVGLGSFDSHGLYVKDPTNIQFIAQTDFQNFNHRGVTVLEEDYLANNVLFLHGHKWKLIRQKLTPIFTTAKLKNMFYIIDKSAQDLIEHLKQHPEKLSGNTYENLSHFSTAALAAAVFGITTKSTFDSPFRVMAKQALTPTLYSNIRFAINSVSDKVSQALRLKFFKDQESFFIPAIKKVIKQRKLDNTKRHDFIDLCVELQNNGPMIDQETGYSMEPTDELMAAQAFFFFLAGVDPTTAGTFGALFELGRHPEIQKRVQDEIDAIFEKYEGKLTYDAIMEMKFTDCVLNEGLRLHPPIGYNTRQCVKDSVLPVGNVPVEEGVKIFTPIYELHHDPKYFPEPDRFDPDRFARGEVNDMTYMPFGMGKRLCIGARYARMQILTMFAHLLRNYTLVTHIQKGGAQFKKEQFQVRLKNCDIELIPRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4M5</accession>
    <name>A0A835L4M5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B9 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4M5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19377" checksum="320807CDBA1F8096" modified="2021-09-29" version="1">MHILGQLQCASNFQDKSLFCRYSFQAGPNWTVVSGCPEGQTVTGKLDHDKTVVWSHPLDIHYVTKGVQGWPKLLVQVSCLDSIGRSWIVGYGCCSLPAVPGHHTIQVNCWVPATTSVTDRIRQYFLGGSHQLVQSDIVNLGLNRFKLKTQSKGSVQLQVTLLLRNFSQFGVEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L550</accession>
    <name>A0A835L550_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L550"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19598">
        <property type="entry name" value="serpin77Ba-like_insects"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF367">
        <property type="entry name" value="GH21475P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032797994" description="Serpin domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="40"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="405" mass="45351" checksum="72A9F7D711B53FE6" modified="2021-09-29" version="1">MARLGTLFLFIAAFISVISAQCNHRTAAPYFKRSIYEFTLDLVKRINQETESHFVASALSPWALLAGMSLGASDTTLQEIKDVLQLHPHKCFNNIYFDLVKQVTAKPSNPTACMLERSSTMFFDDSIFVKPKFLDDVTKVGICDARIVSFVDTVETSSIINEHVRSVTNEAIDEIVTPNDLDGVVTVMVDALYFKGAWKTPFPYEDTETSAFYNDRGQQVGDASLMYVSGTFNVTSINQIKARVLELPYGDDSRYSMLIFLPNANVTLTSMIESMKSISISSIFILYNQHRPSTVDVQIPRFKISSDIDNLKELLIDMGIRSAFDQQANFLGISDYQMYLSNFIQKADIEVTEDGTVAAAATAAFFEARMLPDQFVANKPFLFMIVDRVLHVPIFTGAYSKPTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5G5</accession>
    <name>A0A835L5G5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5G5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="306" mass="34801" checksum="DD776C1735B00DC9" modified="2021-09-29" version="1">MANQHTLCVAANKQSPRLYASGMTAWMRYQILLLHNRHRDNIAVGLEPGQPPATNMRKMYWDYELEHMAEIWARQCQKRHDECRNTIRFNVLQNMDVRAVVSRVTEAQLLSDAVGAWFSGSRVLPPEHVWSFRFSNCSAPGGCNAHWYSAAAWASTWRLGCSQALCTAKKPSCALFRKRRATTRQSYGHTNVTTTSPRTQNLLRRTRFLTTSTTPRFEDYGTTDRNYQPKESPLHRGVLQSQIKEKKRKESKILAYTFCNYGPAGNIDGFPIYEVGTTCSNCPQGTRCGDRMHRALCSVVGDPDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5Z6</accession>
    <name>A0A835L5Z6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_005851</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5Z6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9416935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="543" mass="62794" checksum="7C2A5068077B1AA1" modified="2021-09-29" version="1">MKPMLLILTWVVVIITAVALYLRQAYSSLRRDGINHLPTVPLFGNILWIMLQKEHFVDLISRIINAFPDDKIVGNYDMTTPILIVRDLEMLKRITVKDFEHFIDRRSFTTELDPMFGRGLLLLHGDEWKAMRSTMSPAFTSSKIRLMVPFMEEVCLEMIKVLKQRIKDSGTSHYDMECKEVMTRYANDVIASCAFGLKVESLTADSEFYLNSKSITKFTFWRFMKIMFYRLLPSVAQMMKLSLVPKETTDYFTNVVLGTMKNREKNKIVRNDMINILMEVKKGIVTTLEQSERFEDNKGFTQHSNGLLYTGQLTHEKEDKDADAGFATVEESHIGKKQHNYEWTDTDLVAQAALFLFAGFDTISTAMSFILYELALNSDVQDRLVQEIREYDAKNNGKIDYSSIQSMTYLDMVVSEGMRLWPPAPFMDRICIRKGQCVLIPAYDLHRNPEYFPNPTKFDPERFSHENRDKIVPFTYLPFGLGPRNCIGSRFALCEVKVMLYLLLRDLKLTTCEKTCIPARLSKNGFEMLIFGGAWVRLSVRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L688</accession>
    <name>A0A835L688_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 13D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="81"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1827"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="2867"/>
            <end position="2942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="850"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="910"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1637"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1755"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2473"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="850"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1683"/>
            <end position="1692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3396" mass="368409" checksum="D439AE3BE8EF5307" modified="2021-09-29" version="1">MGECDDLFHECCCQIQTSKILCNNILNCRTKFITASPKRDIISAIKDDNNNRGVRSMTNIGVFKAKVNRKTVVEQRPRCTMLEGLVAWVLNNYLGKYVENLNTDQLSVALLSGKVELENLPLKKDALRHLGLPVEIKAGFIGKVQLQVPVRQIRSAPWLIAIEKLYLVAAPINLDEWDSSVEASIAHERKTALLDALEAQWRAEHEAADAGYYATSYSSWLSYGTGLLANIVENLQLKLNDVHIRYEDAVTCARPFACGLTVESLCAESCDSEWRRGFTLLSDPDGCSFKLLELYHLAVYWDPMPVPTGMFASCTIAELTRQYNEAVCCAAGLERLARVREFRARRPAAPVRGHARDWWLYALSCHIPDHRWTEPKPTWESCLERSRQSRQYVAACLVTLSNPAATLPADRKAAKDEFEWRTPLPLLKALREVAMRKVPKSSPASTPDKPGSSGRSMLVHWFPQWWGWYADSLDNNTMLKRDTVFGKFEFILNKGSLNLCMETEADEDKGVPEAAEGSEGAEGVELQFSCVRVGIESRPRAASHALHVSLGAVCLRERITPNTLFPILIAPQVTITRDTHGVIREGLSSLSASGAAMAWCRAHSQAGASIPHSQQEPLFQLTYEKKPFGMNCDYKVRRLVTECVVCPQAVGEVSVAGGGGERRTWQVELDISAPQILFVEELCSRDSAVLVVDFGRLRLANANLAECAPHTPPDDEEMFMTPCSTPPGSLLSPSSPPDPPPQNQAQPALDATNLHNRLYDRYTARCCTARSGGAVPANPARPVQVQDRAERPADPGGARARQLEVRAHQEYLLAAPAGPVQHPAAGGAARGADQRPAVPVGHRVRLVAGAGRAPQRAQARPRAGQPRAGAGGRRGGEQRELGDGALGAVAAPQLDAVHAAVRDRADVAGGAVHGAQHRGGAGGLASPDARGARGPHGLAHPHALHQALNSLHYNRQESQCPTEPTDPGRASPAPSWMSGTGFNWNGSSMFGADWGTWSGANWGPTATNWGAAGLVDSEALIAVDLCIVKGDADSEDLRIANILFNNLDIIANQETIVELIGFTQRVMGPKTAPKKQSTESNQSEPAAAAAYSYPAPEDEPKRSVRTEITFDFHRLGVLLLRAALHDGALVARKIATATISEARIQATVGRGGRALAEPRLCADGSRVEVGGSLGGVGVVSLCEGGGLHTRVLAAGQAGRADAADAEDAKALQFSIARQLREGAVEASVALHVASVWYTHSGPLLRELRSCLTEFKQYLANLARSIRAAAADMAIGLVHPRGESLYVNPKLSQSTEGVSPRRRTVSLGASLDEPAALKADNIAAPPQPWRRWRAAADGGPCCSVSIELESPVVVVPRHAHSTQVFVAHLGRMSLSNRPGAPRRTRYKVRVRDISLASLDPVLHNTALRLSINYCDPAAGSDADYQCEVHGRVVGGLHVSARREQYEQLLETLRWVSSETPDVADSGSPAGPQRAAGALLEGAVRTLQLDPAVRAAVLAVPPPPARAPPAPLAPLTVNFELPTFSVELRADLGEGERSLVELSFREFKLKYQKTHPYENMLQVSLHSITMEDLTKEPDSKHRMLMVSHTPQMPPKAVFVSKSCPDFVTEYPDDMSSVSSLQYMKWCSCSLPSQLNVLTRESKERRNKRDSKCAPTPPCSPECGAPSPAPAAPRPTADPAEHSDPADPIDAADPAESTDPSDNLVWLSVHTRDPHHPQFADKYDKISKLIKVDFNCLNLVVSIDSWVAVLDFFGIAGDDATDGQHGPEPPSTGRYGDKTAGGARGSGVSRARGACREGGGRRGRRVLADGGVGAYQRLSSAEAAAAGHETSLSIEMGPVTYVHTKRFVQELQAFARDFSLLRKVIMQARLKVSVVSGGSGTDGARPARMKLNVRCTAPVIVLPVSGRARNALAAHLDQLTLDNSFKYAGSEGGGALLDVRSVRLAGVALWCARGGRGLRVRRRGAPLLRAPADLRLRIEYNMDAGHAVPDMTVQGSLSTLQLALDPAQYRLVRGVLAHNLAECVDDLLPRDLPHHQPEPQHQDVWTTSSLKLDLHDVTVKLEPEHGVSSLACINFIKSRLVVETYSDLSQDIDLVSQEILVSDTRFAKEPANRRGNVFSHIVQPMAEQRHSVQAEVHARKRRDSSAYTILVNNMRLMAVLDWWECANQFIMQPPPPPADPDQAHLEEALCAMRNAASPHPAKAQEEPLMELKLNVTDSQLVLVEDPSVWDTNAVILRSTTVITYRCADAQKPVSCELNELEVFSCVLGLEEETALSIVDPAAVHVAIDAQRVLHVAMSTLNLRLSYHDMRMFAAMLQSLPVQARAALAGKLLVSEEDADEPANILIHRIIMSLRTVDGRARLARAVVEWLSGCVAAQVAADCITLCVIDDCLDSDVPLLEVSLSDLHVDQFLQNTCIDKKSISAGNILNLLIRFETSWEYTLTSELSLGRVQVEVASTEVLNTNVTSSLIELAELSSATQEQSPKGSPSGHRRRSPFVPYALRNHTGHRLLFTTLVTTSDELREQTSCSEPDDSWMMNAALNQLALRLDGWSPPDPVCVDRVGVFFRNLTHTVSRSCDVSGVVTSIAWMSLNELHSYLQKSGAEARIVFEVSLEGSARKLVTVRSALQLVNKLPHPVEVRVDHAPSAGETYMRLALGCEVGAPVVGRTMDNIGAPMLRAAAWSGGSVRTAQVGAGATWAAPLSAQPAALWTRPLLRAQAAPPAPSPAPIDWRNAPGDRALLHYECRAPPDHVYRFCCVIVRERFPPDRGTPIAGHTLTLVPALRLENLLPLELQYRACPAVPGTTTVSASGNIPPGDTMPFHECTPQAAGLPRQEAVPQRQGHRQENRRHQGYCSCIIPYGRFGAKLKRMSQVSISAAYWLVNHTGLPLVFRAEGGATEAAGQFDEHELARMVQPLLFSFAEADGGPTISARIGRGLPGTPELHNNTSHHLQFAQKCCATTLTDPGAMATHVSAVAGCSLPWHWARWERPQLLEPGGGYQFVRVEVVSQGATMFVVLTDAECAPPAAHRQLLPRVHHVPPGRWRVGRAGRRRRQRWAAVSSSVAQVGCSEECVNFIYVAFSATHPTYSTGARPAQHADDDAVLVLEVPLGSTRVVLARKRYGDRSQLWRRGPNEQLIHEGSSPPQPTDVLLSDDAPLSPHAMPEGLSLMALTPGTRVVLGLPASGRAGWSPTSPVPAEQAVSWHTLRPGSGRLDVTLCADGPTRVVKIHDHKEPEAGWLEGGADAEEDTTARRRGWGEWGVRVSLAGLSVSLVSRAPPAELVHALFDAVLLELALQPRSLALALAVTHMQWDNQVSSLRMLCVRLVVACSVLLYLLLLGTPSPVLLYCLPERGGSAGGALPALHAAVELQRAPAKRYNAYFFKHLVVALRPLAIRLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6R4</accession>
    <name>A0A835L6R4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6R4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14795" checksum="1410A005411FE7C8" modified="2021-09-29" version="1">MKHQQVSVDYWAMLKSMLMYGVLTALGWFMLRLFNAVFSLPRRLRTQQENIQATLEEFQRRYPDLNVTEDDIKNAEKELEEWNKEMDEKIKNQEQAIKSKCETDGICEKCDEPVAQEGSEEKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7N8</accession>
    <name>A0A835L7N8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7N8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="90" mass="9661" checksum="E175F6DE64C1C6AE" modified="2021-09-29" version="1">MISQIRNTLKRKAFEDAGIPMREVSSTVTNHTKQAPQPAPAPLSVINRQTVIGQNAEVTLNMLNASEIDDVDGLSGGVKLEFDPNDDAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7V0</accession>
    <name>A0A835L7V0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7V0"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="374" mass="41568" checksum="F382DD87CA446F79" modified="2021-09-29" version="1">MATSQPKPEAMEEDSKKPICLIILGMAGAGKTSFTRRLAGKVVDGSRPYLINLDPACREVPYPANIDIRDTVNYKEVMKQYGLGPNGGIVTALNLFSTKFGQVVDLIEKAGKKHKYCIIDTPGQIEVFTWSASGTIVTEALASSCPTVVVYVMDTVRSVSPVTFMSNMLYACSILYKTRLPFIVVMNKTDVVDNSYAVEWMRDFEAFQEALDAEGEGETEGGNTYIGNLTRSMALALDTFYSDLRCCGVSAHTGDGLDEFFKLVDDAAEEYERDYKADWLKMRAEKLEEEKRKAEELKNKGPDDTVIDKKKLIEEVSGGREISDMYLKHPANESSSDEEGTENEPEIDDKPADVAMFNDFIRKHVKPNNTGNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L844</accession>
    <name>A0A835L844_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L844"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000010">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="11">
        <location>
            <begin position="49"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="270"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="462" mass="50012" checksum="CBF1D9F0A9A7BF35" modified="2021-09-29" version="1">MVNRKRVFDLLRTINVASCQCPAHGNRGNIQVSNATPQKDYAFEIKCSTVRYGLGVTREVGQDLVNMNAKHVCVMTDPNVVKLDPVKATLDSLTRNGVNYKVYDKVRVEPTDTSFKDAIAFAKKNSFDSFVAVGGGSVMDTCKAANLYSTDRDADFLDYVNAPVGKGKPINVQLKPLIAIPTTSGTGSETTGVSIFDYESIHAKTGISHGALRPVLAMIDPLHTLTMPEKVSNYSGFDIFCHALESFTAIPYNERSPAPPNPALRPTYQGSNPISDVWARFCLQTLQKYFTRSVYNADDLEARSCMHLAATMAGVGIGNAGVHLCHGLAYPIAGNVKSFVPNDYGADPIIPHGLSVVMTAPAVFRFTGPSDPAKHLEAASILGADVSNAKQADAGKVLADTILKYMDTMKIENGLSTLGYTREDIPELVKGALPQKRLLSMTPLPQTEEDLSKLLEDSLTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8R6</accession>
    <name>A0A835L8R6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_000656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8R6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9424263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="23249" checksum="9AEBEFC4B505EAF3" modified="2021-09-29" version="1">MNQAEVSKLVSKLRVKVLPRHRNLPGPKGPEGRIDKLRKTVTGLIKFERIELNYNRADEARQYAERLISEAICHGDCHKPTMDTADFWLLEKELVHKLFKVLVPRYENTKLSYTRLYNAPKPQYGRSIEKAVLELRGNPYPDLLNNKSNNKLLIQNVLLDAAKNEYRQTKIAEMAKNIGKKEGVTQNRDSKTNEAPEKPNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L929</accession>
    <name>A0A835L929_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L929"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="379" mass="44573" checksum="77F19E777821387F" modified="2021-09-29" version="1">MEKLCFEFTVLPASDGKSSICCLTSIATIGGKVYALPEELQSVSHHKELIKTTVFNKVKNSLKKRYQTRRVWISMNGDLKKTYLDEDENLQFEDQYLEEVQVKTAVAQDTQTGVFEKLFEQLVQNTQESTQQNLKQITEKFLIEKFTSKNPNANRWIDTFEKECTRFSITEDDKKIEALRLLMDKCCTDWYNSMIIKYTIDSDWTTWKNIFCETFTNKGWTQISYALSFKYRDGLLLDYAIKKEKMLLEMRNSIDTGTIIDLIAVGLPEHVLNRIDRETLKDTVDLFNEVRKFEYLVNKRSYSFYRKHSGNSKGYNINDRNEEKNSCKICEKLNKGIRYHPESACWYRTKEEEKPKVKNIRHVNNSVIEAQLNEAEQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L968</accession>
    <name>A0A835L968_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L968"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="18085" checksum="E01D5451965943E5" modified="2021-09-29" version="1" fragment="single">FFHYLFDLKLIRVVRHQNDSVLLQKDIDSLCRWCVENKMYLNCAKCYHIKLTRKKNKILVRTVIRGLEVQLDCQLCFNRHIDTIIAAAYGALGFVLRSSKVLEPHVDRIESVQKRLINHLAYRFGVKYTLKSYKKRLKHFKLTSYCLGLTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L998</accession>
    <name>A0A835L998_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L998"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032628627" description="Farnesoic acid O-methyl transferase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="4">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="591" mass="67694" checksum="AC4C7362A57FD6A3" modified="2021-09-29" version="1">MLRTIVCVLFFLFCNNVQGENVTTFVYTSNMAKQCKEHICQDGYNYKLFYSVDTDNLKAVSKDSDTAFEMHLGIQATSNGHILLSPVLRPGYNDPVYEIVVGGGGNQFTELRRNLKRNARNSVKTPRILSSFEVRGFYIKISHDGLIEFGKEGETLPLLQYNDINPLEIKYFSFAAWTGVEAKFLYDCPIPTASPNSKEIEPSMSISDQLKRTLLLYRLPWIPPKPTMDVKVGIKVTNVKYDPFISKLSTSMSIVTSWTDESMSWYSGKYGNITSLNSDKQMPLEAMYSDLVSMVNTGEATFHFQSTVSTWCVDTPPGYSKWPRDEYLCSIVIQPWEAHEKISIDIIEPNNSKMHIFSDVDKQIENQWEVSIKQLVIKPTVWNQVYISDDNETHQSDRLILSLQLKRRATAFNIVFYTPLLVLLMFVLMSFWSEPLTMERIWFLAGCTIVITMGLCYMDFLIPSHLIPSILILYTTVLMGVLIALLIQALLITDVFEKFRNLAFVQKILNAHVFRIIFWLPAYTKSSNRNGGYSLQEDEEPQSPITRGDVEEMEKETPRTCGDKKELAEVIDKIMFVIYFVTFISMLAAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9U4</accession>
    <name>A0A835L9U4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9U4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054521">
        <property type="entry name" value="HRI2_3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF187">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22949">
        <property type="entry name" value="HRI2_3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="166"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="554"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9415872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="600" mass="67820" checksum="1E4B13FA1F5693B9" modified="2021-09-29" version="1">MILGYNILITEPEGQERITMENKQMEDKWKALATIKSFDLGIAQNSSHHSVFNQSLEQIEVINSAATTPISLLVQSLVKQLCSLLEKDNIRANQLYNTICEKLHSMNLIDDSYAMGEFEAMRSQYQRALYQLVAVASGSEIPITLPATWPIVQPSGLEWSRYHREFEELFFIAGGGFGSVFKAKHRLDGVEYAVKKVYIKSSDVDSIMTHLAEVKTIASLNHPNIVNYKAAWLEPMIESTVKKKRKFKMDTDSEDFSINSNLISSAHPNIITSFKTHNSKELVNHESLSDFVISFQNSNSYTSSKEDLEESEFISDEDTPSPQEDNAVCNLFSSKEFENCSRVNLKWATLYIQMTFCQQTLKQWLDDRNLHMTASRKGSEDITLHHCDSSESACLESQDMTYPVAWTHIDVLIDMFTQLVKGLHYIHSRGIIHHDIKPSNVFVAQSEGGVTVQLGDFGLACPLQQSHSGLALGTHLYAAPEQLDGQCNPKSDMYSLGIILLEMVEPFSTDMERVKTITDLRKGQIPAHLTANYPKIAHIIGKLVQRRPAKRLDTTQLLEELKNLAENKDDTIKNLREELAAKDDEIAQLKLMLAKFNYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB85</accession>
    <name>A0A835LB85_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_005392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB85"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="16"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="541" mass="61367" checksum="4EC39D8B6DA308BD" modified="2021-09-29" version="1">MWDFFELFFYVFSAYADINGLEGITGNGEYLSFKGIPYAAPPIGPLRFRDPQPPLSWTSVRDARSHGATCPQVDINTNGNFSGNEDCLFLNVYTPTLTPKTPLPVMFYIHGGYYVKGSGNDDQLGPDFLIDREVVLVTINYRLGVLGFLSLDIPEAPGNVGLKDQVAAMVWVKKNIAHFGGDPDNVTIFGQSAGGSAVTLHLLSPLSKGLFKRAIAMSGAFFKDFQSPFEHKKRALLLAKQLGNCTNDPNEALSYLQQAEAVDLVTAKPFLLYNEQARRELLEIMNFRPIIEKPMESGNFLTEDPMELLINGKVNSVELVLGHTEEEGIYRAVTQKDYLLKYYPYDEFLVPVRIANEKTGSEVLDIGNDIRRHYLSDCKLKEDNKNMKELINFYTDFTYVHHIYRFLEMWIKAGLEAYFHVFTGYTDRNVYGKYGERYGLKNSTMQMILDICLVDPLTRHWEMILEKFLTKLVTCIQISLNMGTNPTPNGTVWQPYNTNSSNYLTIDLELTPKVVHNASTLRFWRKIYCNAGQKFATCECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBB2</accession>
    <name>A0A835LBB2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="84" mass="9725" checksum="ED85434E864C1C2B" modified="2021-09-29" version="1">MSKGDVMSERDNTSISVAAGGACCRIRRRMQCFGFQEGGKRTSLRTRIRMCRIVFRVWIAQMRLSFFFIKTEKIGKCLCVRSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBC2</accession>
    <name>A0A835LBC2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_001352</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBC2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08834">
        <property type="entry name" value="ArfGap_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07604">
        <property type="entry name" value="BAR_ASAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000006">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000322">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF3">
        <property type="entry name" value="ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="263"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="16">
        <location>
            <begin position="383"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="848"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="657"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="805"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9423283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="101671" checksum="ED93314C95B8A34D" modified="2021-09-29" version="1">MSTLDFDRDGLTKLKKAIKAIHNSGNAHVDNEMYLSRALERLGGNALSKDSEPDIGAAFFKFAVVTKELSALMKTLMQNINNIVMFPVDSLLKGDLRGVKGDLKRPFDKASKDYESKYLKIEKEKKSQAKEAGLIRSEVTPAEIADEMEKERRLFQLQMCEYLIKFNEIKTKKGIELLQHLVEYYHAQTNYFQDGLKTIEHFGVYVADLSVQLQKIRQQQDDERRRLLELRNMLRAAAPQDREVVSSVGGYSLHQMQGDKQHGVSRSGYLLKKSEGKVRRVWQKRRCRVTAEGFLDIFHADENKTPARVNLLTCQIKVAAEDKRAFDLVSYNRTYHFQADDENEQRAWTSVLVNCKEGALMRAFHQQAGETNDSGHSLLDLQRSIIRAVRAMPGNQVCADCGSTNDPTWLSTNFGIIVCIECSGSHRELGVHISRIQSLTLDRLSTSQLLLARHMGNQMFNEIMENTLDERDKLTPESSMEERLRFIREKYVYRAFAAQTCCDAAERLSEVEHAVNNGHLQNLLQAYAEGADLAAPLPGSDLGETSLHLAISREIGDGSSLHIVDFLVQNGGSQLLDKPNSQGMTALHLCAATDRTEPMKLLLKAGADSTIKDATGRTALQIARQYGHLGCLELLENVDKREKSIFENINIDWNLSHDDGSTDFSDDDTVIDERQNGSLTPEKKCPRSRPPSYAGGAVLSTAERCPAAGDSPVLRSRSSTCDSLHHAPPTPTTLPRKPNVLSGGVVKVRPAQPPPTPPTPPPALHNGAHHRDEPTPPPRKECSSQDSSLELCDMTDSCLDDSRLQSALSCDSSRSRERSRRSDSRSLDVSDTSSVHSRSPSASITMMGGLRRCRALYDCSADNEDELSFREGEVIVVINERTEDDNWMEGQVEGTSRRGMFPVSFVHMLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBW5</accession>
    <name>A0A835LBW5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBW5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9826" checksum="D1E9F2957E03E4E4" modified="2021-09-29" version="1">MTTLCLTKINETKCQRRCPTETPWQRGQTTFIGYVSSRPRRSVQYPPQSQQWLDGPDIRLHYGQTQSPLVQQLIQNLRTLAIAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0R5</accession>
    <name>A0A835G0R5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_013837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000746">
        <property type="protein sequence ID" value="KAF9405409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0R5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9405409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="439" mass="49208" checksum="D3113279FCBA80C7" modified="2021-09-29" version="1">MSLVFGNFIAPTTMSRYGRKIANLISIVPLIIGWAAIYFANSITILLLARFLQGLCMGMCTSLGSLLIGEYTSPKNRGAFLMTISVSIAIAVMSVHSLGAHFTWQTTALVCGGISFIDLFIVLYSPESPSWLAQKGRYDACKQSFRWLRGEVEEEELRKMIEASILLREAEADMQQTKSWIKKFRNQVEYFKTTVKKKEFLKPIIIMIHIYILGQWSGINMLVAFPIDLFYKMVGNKCDIPLLVLTLDVHRILANTTALYVIQKVKRRTILGVTVCINIIALIACAAYSYAKEAGHIPADEFGFGVSIIHIHMFAVATGSLPLCFIIAGEIFPLEYRSLAGGISVLFYSTNLFVTIKTVPFLLSSIDLYGTYLIYTSLMVYSLVIVWNLLPETKDRTLQDIEDEFRGRPLSPEELKSVQSLASLRAITTDRRCSNPIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1Z3</accession>
    <name>A0A835G1Z3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000883">
        <property type="protein sequence ID" value="KAF9404786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1Z3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="523" mass="59960" checksum="87ED208AE18C4E58" modified="2021-09-29" version="1" fragment="single">RQSEIISSITTIKVNFNKDSDSRKNAEYIKKRLGALDALWEEFEQNHSRISDHASEADEYFRLNTYQVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQRTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKLHRYNNEQALFTHQIEIFLNQPNIQKQSSSEIKRLYDTTTECIHAIHNLGVNTNAWDPLLVHLLCKKLDTDTQTDYREARVEPRKLPKLDELMTFLEGKFTALEQITKYDKEPATSIKRTPNPKVQNNYYKYNNYKGFNHRNYQAQAIHISKCAVCNLNHNRNLFSCKKFINMTPDLQMRIVTQSNICKNCLFSHDGNECTSTKRCKSCQGNHHTILHEACSDGTYITLRALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQSKGLVSIDCQSIYGDYNFTTEALVLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLLDTVEPDTSRMNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G403</accession>
    <name>A0A835G403_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000590">
        <property type="protein sequence ID" value="KAF9406450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G403"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="370" mass="39669" checksum="DA72AD679A0A3862" modified="2021-09-29" version="1">MILTCIPTLISSDFECAGDEVLVESSPPASPDMAARLAAPTQGGGAGGAASPTSVRELIVIPEIPDSMHLQHAMQQVSSTVVEVNGDSSGHSSPTTDGQHTYITVSSECEGGNGVNYHVQYVTEPQEIYTQGHPTHMDPLRSYPVYGVTTVGNGTSAEGTSTDNGWGGASSAEYTAYGVVVAGDEAEAPASPATPGGGAPQPPRMPPATVQWLLDHYETADGVSLPRSTLYAHYLRHCATHRLEPVNAASFGKLIRSVFLGLRTRRLGTRGNSKYHYYGIRAKPGVEHEPIEPRDEISDQHDNVDDKTDVLDHQEGRSRDRSRDSTSSPGHAHRQYMGTVSPPEPPPLNIHPLPEDVSPEALNALRRHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G414</accession>
    <name>A0A835G414_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_013478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000655">
        <property type="protein sequence ID" value="KAF9405977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G414"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004941">
        <property type="entry name" value="FP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03258">
        <property type="entry name" value="Baculo_FP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FP protein C-terminal" evidence="3">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9405977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="193" mass="23027" checksum="4F5B0043825ADF2F" modified="2021-09-29" version="1">MDFKEESQKKIKALEQKNVYLEKCNKALEERIQDLEVRDKEKNIEIHGLEKHGNENTKQVVRKLAEKLKLDPNDIEDAQRVGQEKPDDTKPKTVLVTLRSKSARNNWMLVKKESKIYNDKVYDNGSENRIYINEDLPKYKRQLLWMVRNNLKPKGFQYIWVQNCNILVKKNSEEKKIYNIRSEDDLKKFDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4E9</accession>
    <name>A0A835G4E9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4E9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="366" mass="42742" checksum="DFBA48C5B5929FA2" modified="2021-09-29" version="1">MIYKNNLLSKTESNWQMATTRMLRTQNLLCLIAILLQFVYGLEAQQHSRRYRENEVDDYGKEYYDMIIPDLEEALMKMEELLIKAESDNDDEAFENLLEMLHNLVEYTRNSNNAYKFVKAKGIDRIIPQHLKSSNNDVKTRTLIFLKSLFDIAPTTMSASMPIVIVDRILDIFEKGNLALKAHALDVLEYWLPENPRVQARVMKIKGLVPFYDQVDKLDMRVIATLLNLFNIILKEHITVRSESQKHLVDNDKMKFYLRIGLLEHMSSDTICGGLMNIFTKLWSYSTNEHGVMVVVFDLMKNIKPYCLKSYQSDEKAQKLFSALSEFVNDQGNKEFFDMYEQNMTDVALVIGEYVEKLKYNVKDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4G3</accession>
    <name>A0A835G4G3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_014058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000839">
        <property type="protein sequence ID" value="KAF9405002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4G3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="80"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9405002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="267" mass="29480" checksum="6B0325F942E6C450" modified="2021-09-29" version="1">MITAASRTTKGLNFRLTFIKIYFSPLLLSIADTTNTSSFFEACLHALLTQLHELLVDLVTPLRCFELKMLLMRPHRVPLGWTALLGALLLLTLADREDLESVLHRVEWSTLLFFAALFVLMEALSKLGLIGYIGGCTEALILRVDESDRLAVALILMVWVSGITSAFVDNVPLTTMMVRVVTSLGTHPTLNLPIEPLIWALSFGVCLGGNGTLIGASSNVVCVGLAEQHGYKITFMQFFKIGFPVMISHLVVAIAYLLVFHCVFSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4P9</accession>
    <name>A0A835G4P9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000653">
        <property type="protein sequence ID" value="KAF9406001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="253" mass="29304" checksum="3C406D66BD046B98" modified="2021-09-29" version="1">MNSMTKEDSYAERRQLFKNIWETAMQMDDKDADNIMNKPKVIKTLRLDEVDRCFIGKRKKEKIRTLRTVCKKILDFCDEQDEDDRFFEQIAEKNELRLHKLKLKHKKTHRGRKKVKTPQSLFAPLKSISDLAKPTTSEKKDGYSRQISEPNTTRKDSPIKTKRPLIVRRALVKHKISRVKSAITEGNNAVTIRRKTVKRRRTKRKKPSVGGTVAPSKPSGTSTNMRYASTPSKGHAIVRRIKQLLTDHKIAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5C1</accession>
    <name>A0A835G5C1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000676">
        <property type="protein sequence ID" value="KAF9405819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5C1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42429" checksum="203934EFAA2D9440" modified="2021-09-29" version="1" fragment="single">NARSCTFHLGANLFHELYAAENALSTFSAAHIEEIVFLLAEETQLDFQNPENIDEHLFKYWFGRTKAEFNEVLVEVPQLNDAKMKNGFSALLCKMRTGDSDERISTLFKIPRRTLEDHMNKARGILCQYYVPRHLGWAHKPRQEFVARNTALAEHLFGNPETPSEERRLIAIADGTYLNFRIAAAFLNHFAVQFRERANVREIIEIIDAKIFEDNELCEVVQQHNLNMRSTLFQSISHTNIEFPELTINDLELIALGTYQIRQAKSYVGEHLRVHGMYTLEVCQDNAPLQGIFNDSQPSIIRGRIKSRHIGINRRLEGRSAIVGYYCHCPVGTRTVGCCSHVMSILWYMGYARHQESISAPATFLDNLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5V0</accession>
    <name>A0A835G5V0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5V0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="38" mass="4515" checksum="FE04F4336E7C7B8F" modified="2021-09-29" version="1">MCRLSPLIVILNIGSLLQHHRHSHHCRNLHHQSMHRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5V3</accession>
    <name>A0A835G5V3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Striatin-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_018076</name>
        <name evidence="5" type="ORF">HW555_012453</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000457">
        <property type="protein sequence ID" value="KAF9407571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000281">
        <property type="protein sequence ID" value="KAH9640410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5V3"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="441"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9640410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="94732" checksum="DE46492B648C9A45" modified="2021-09-29" version="1">MGTNGNGRRGGTKIPDVRRPMEEGDCVNDMESPELDFVYDDCDTQANEIAELYSYTEHPEYQLNVKAFEDIMEDFNFPPSWQRLTNKQQRTVMMKLLEHLDVAVSEIRMRATRCILYLAQGCWAEMQSDAEQAHWARVNVMMLYDMGTFSAFVELLNLEIVRSSSAIASRKLAESLADSTNLRVILSVLYLITEYMRTEKDNPESEFKHLVKNFKEELGSPFGEELLPVKLLSMVTHLCAGTTPHFPMKKVLLLLWKVLLVFLGGSKELKERKARLREKYNLPPSSEDTIEIVKGMRASSPPPSAADMLENQNPGQRKLLKENEREGKIRRHLFMKQTSLDESDEQIFVDKEETGNGSEDYSMEFQSIPSEGSQSENNPNCPYYMYFKQFDSPPPPPPLPRSLPWQSKVRQKDIDTFLDNVRNKFVGYSLPGDRQTTAGLPQPIHEGIEILKKHVYTSLSELQAERELEIARSPLTKGEKEVEDTEVEILYRAMFPNLPQYMIALLKILLAAAPTSTAKTYSINIMADLLPEEMPMTVLQSLKLGIDVNRHKEIIVKAVTAILLLLLKHFKLNHVYQFEFMSQHLVYANCMPLVLKFFNQNILSYVGAKNTIPIFDFPACVIGEQPELTKECLDIGDSTVPYSWRNVFSCINLLRILNKLTKWKNARIMMLVVFKSAPILKRTLKVRHALMQFYVLKLLKMQTKYLGRQWRKTNMKTISAIYSKVRHRLNDDWAFGNDVDARPWEFQDEECALRVCVDRFNTRRYGSGGDQEIDLTPLETDINSVLETNIELDEEFKHNYELWLEQEVYNNEINWDVLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5Z8</accession>
    <name>A0A835G5Z8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HDAg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5Z8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037517">
        <property type="entry name" value="HDAG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052828">
        <property type="entry name" value="NELF-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328:SF4">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A NELF-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51838">
        <property type="entry name" value="HDAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDAg" evidence="2">
        <location>
            <begin position="89"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="572" mass="62027" checksum="C3D7EB3C79103FC7" modified="2021-09-29" version="1">MANVRDSDTSLWLHNKLGTSNDSWTSGSICTQLNAEVLKNIKDCFPDLQTQVKLKLLLSFFHIPRRNVEEWRNELEEIIEVAAVDSDLWVAMLAETLKTFPSAGTLNTEIAEFDETRPIFSDMISELRRALAKHSDLGLLPLECLYLNKNALVSVVGQQPNPVKHFTLKRKPKSVALRTELLTKATEVQANQKKAQAPTVPVRSRGMPRKMTDTTPLKGLPSRFGGARGGTWRGAARPPPRAGIKLLDITEQPATHAQIKKRRKLEMEEGAKKAAAAAPPSPPPPDYAKGLNNYTVPKPDENTNATSSSTTETAPPPAASPPPAGPPAATPATPDTPPPLASPLLVHGTNAKPIVIGQQPKLLIAGPAGGKPLLLSTQNLLNTSTVILQPGGKAVLLQNIKPWSLYLCIEQCIVPRQVQLPASVPPAAPPAPAAAPAAPALPAAQGQPLLPRRGLSLTREQMLEAQDMFRNANRVTRPEKALILDNPCPNLGNIVTIKLSENIENVLQSDDTYLTMLSEMHFQMNYNNGQWTRLKKYRHIDGMVPQKIPPGSTVISSNNQQPIVSIANQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6G9</accession>
    <name>A0A835G6G9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000466">
        <property type="protein sequence ID" value="KAF9407486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6G9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="335" mass="38110" checksum="808968E140815314" modified="2021-09-29" version="1">MAVWQNKWRWDTGYSADSVEWCPVEPYRDVLVCGTYQLDNTAEGNAASRQTRLGKIYLFSINENTAELAPIHSIDTSGILDQKWCYHKLQNLPTLAVVTSVGTLQLYQLTNESGVLQLTLWLEHTICENGLALSVDWSTNKTHADEPYLAVSDSAGCIHILRIVENCVKVLGKWESHSFEAWIAAFNYWNSDVFYSGGDDCMFKSYDIRVPDVSTTVNKKHEAGVTSIRSHIDDEYQLLTGSYDEKVRLWDTRNLKCSVRELDVNGGVWRLKWHPNKPCTVLAACMYGGFRVLRVNDEMEVLSEYLEHESIAYGADWKCNSDLVATCSFYDSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6S6</accession>
    <name>A0A835G6S6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000381">
        <property type="protein sequence ID" value="KAF9408462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6S6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="372" mass="42965" checksum="E5593FCC1283C784" modified="2021-09-29" version="1">MFRSPKDMVYQTKPKEIDEIITDDGFNCDLCNSGPYSTEFDVEIHRRSAHKWEIVKALKDDDVAICSICFYIQKDKESLVQHILTDHLCSSPDAKVINREIFVCDYCDHLFFNKDLLIAHIYHFHVAKEVKKVSNIRHNCPKCMKLISAKSTWFHLLSHGVINSRVCPICLKCFNRNAEVLNHVKTHKAHLRCNICGFVTMKEIILSSHLKKHRKDRYFTGKADVSKYFVPCRLIPSTRKQSHVMKGIPMASEVRICVICRTVCLNNDEMLMHIYGDHAPDEKEKSKKYQCVCGEEFFNNVLLKHHIFKMRSGHNVFVGEPQESGEVKHLCTCGMEFPNTLMLKHHVMLIKSMHEPCDEPMVSEDGQLGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7F9</accession>
    <name>A0A835G7F9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysosome-associated membrane glycoprotein 2-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_012229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7F9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="9">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9407897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="20573" checksum="9336DA9AAC6B6397" modified="2021-09-29" version="1">MFLFSTATSLWYVRFNVPANASVLNGSCSDPDQWIQITWKTNENSMINNTMTLVYHENATTKNYGLKSLNLTLTPDNFVNGSKDPIELYHGPEWVTPLATSYRCKSATQLNLTSESLSAVAVLTLSRLQEEAYRTTAGSGFSAARDCGGGDVPDAVPIAVGCALGGLVVVVLIAYLVGRRYSASRGYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7K2</accession>
    <name>A0A835G7K2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_012391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000448">
        <property type="protein sequence ID" value="KAF9407658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7K2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="9"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9407658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="544" mass="59626" checksum="C9FE0763EED7F2B4" modified="2021-09-29" version="1">MKPWYQGSVLVLTFFTYMTYHLTRKPISVVKSVLHQNCSALVPPPGTDPSDDQWCNWAPFNTADANTLLGTLDSAFLFSYAGAMFVSGMVAERVDLRYFLSLGMLTSAIFCYLFGIGRTYNIHNITYYLLVQAGAGIAQTTGWPGTVAIVGKWFGNSKKGLIFGIWNSHTSLGNILGTIMAAEYVDSDWSLSFIYPGLVMGAVGGVVWLFLAPDPRHLGLAAAVNGRNSPSRQSTRSDEEDEGLEDEESSVIVGDQSASLRPNRYSANAAQSQEDVTERTSLLRAPAADGAVSLGRALAIPGVVEFSLSLFFAKLVSYTFLYWLPSYIRYTLPNLSARQSGELSTVFDVGGVLPSSTNLRRLKCATWAGRHTGRPRRRLQRRARPRLCLLLLCLRAHGQYTLHSTTIYRPSEPETKLFLYQWWGGTSYLMSVILLVMTGALVNGPYALITTAVSAELGTHHSLAGNSHALATVTAIIDGTGSLGAAIGPMLAGVVSSHSWTHVFYMLIACNFMALFLLLRIAYTEMLKIKQERRMASPPRVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8E6</accession>
    <name>A0A835G8E6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000281">
        <property type="protein sequence ID" value="KAF9410038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8E6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="25491" checksum="317B787121DD875F" modified="2021-09-29" version="1">MSAHKTFIIKRKLAKKLKQNRPIPQWVRMRTGNTIRYNAKRRHWRRTKLKLKGTPKSTQRPVQQRTESRSPPTKASMGKVCLQRLRHAATPRDNVVNAFLEFVAVVKATCGIAKPSYKLRYLQGFPGGGGHMYQDYARRKDIGDCRNLFQNPNRTAQSLKTSPPKFRWTNGVDVVSPQQLKQPTTSEKNYPVELGISEIEGPNDGVHLSKRLGGTWELLPTYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8E8</accession>
    <name>A0A835G8E8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_009830</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8E8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="508"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9411330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="928" mass="103151" checksum="248BC5787DA84B39" modified="2021-09-29" version="1">MRESVQESSNVVFREGSARWCGAMSQVAEDTDDDVDAPYISSDESAHGVDLAERLRVKPSPDIWELDEIEYNLRHLPLAEEISATVATGHYDETIEIAANVEDGILTAALWACWHGRSSLLSKLLKLGLDPNRTDEAGRSCLHLSCLVGSEECAKLLLEHGANPNMWDSSTDKKATPLHCAASAKSLACVKVLIAHGADVNAGLNERSPLHYAVLSDAPVVVKALLEAGACPDTPQVFTETPLHVAASLGSATCTKLLLDAGADVRAALGAGRATALHLAAEDGHAECARLLLEHGARIDLPNGRGQTPLHLAALAQSLEVVELLVCKRADVRVRDGDGRTPLHGAIVRGARACDVARTLLSAGADPNASDNFGYTPLHIAALNEFSACVLLLLDYGGDVTLRTNGGVSALSFIVRRVPDVIPRYLGKLDEAVHVSEHEIGDVDCELVIDFRPLVPCLSRGEAELLLAFIEVGRKDVLKHPVAETFLFLKWRRIRKFFVMSFIYHALFITLYSLYILQIFLCESRTCHVPTYLRPVQYLIILLNLCFLSKEVFQACLDWSAYIRQWENWLQCLIIIGVFLCTIPSWDNGEIRTNTSSWQHDIAAITIFFCWLELMMIIGRFPTFGLYVQMFTTVTVNFATFLLAYSCLLIAFGLAFSVLFSNYAAFKLPASLVKTVMMMSGELEYEDIFYSNSTTESDYPVTAHGMFLIFVLLVTVILTNLLVGLAVSDIQALQESAGLDRLVRQTQLVAHLESMLFSSLLTCAPKQLLGVLRWGALLTASHTRTLTIRPNDPRENRIPKDLISSVYKMIASRKIIQKSIKNNNNYVFRLKRCKDEEDTIKQNQVKRRSNLFDRYSVESQQVERRKKTNSTSNADRVRPESLNINAIQEICMVDIKTQLLELTKRVNKLIDTTETRLQRIENKLNHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8L1</accession>
    <name>A0A835G8L1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000302">
        <property type="protein sequence ID" value="KAF9409683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8L1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="239" mass="27827" checksum="7FD99287126E71B9" modified="2021-09-29" version="1" fragment="single">TNMSIEEVAGPSLTNRNTFSFITSQRNRPILLKDGYKYLHLRTNKDKSSMWRCSKKSTCQAMIKLNFNNTTILKATDHNHEGDLTNNEILMNLNDCEDQVKHNLAASVPSLYFDTIERMEERGLHLVANIPRFQSVKNKLYRKRNKSLGVQRMSFNNIAEIVVPEQFQDILLADRIGDQRILVFAHHNMREIVANSNKFFCDGTFKTCVKKFHQLFTIHYGISYEHYSHYLCFAARQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8Y0</accession>
    <name>A0A835G8Y0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000291">
        <property type="protein sequence ID" value="KAF9409883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8Y0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="172"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="466" mass="52934" checksum="28B1D27BC9204D41" modified="2021-09-29" version="1">MDGSVTVANRPPPNTVDEVASGYVANEPPLSPAISVPSPSTFIECATQNSPTTSSVPTALPRSRQSRLRDEDICRVLNYGSEPSDGESDDEDLVAPLIPRTFRCLLETPVDSEDIEGQPSFVVEAVPMSTTERPWAVNDFEWSAFPNPPIPPESRREMFCESNVGPTTQSVDPYDIFIAIWDRQFMEYIASETNRYAQQVTTQMLDNNRLFPNSRISQWRDTTADELYVYFGLILGMGVVVKSRLEEYWSSSPDLFVTPGFSAHMSFNRFMLLNKCLHFRNNEDMCALRLDASEAKLFKIQPVINFLNTAFQNLYKLNRNISLDESLLQWKGWLDINQLIPNKAATVGIKTYEICESQTGYLWRFEVHAYKKSPLQQTEDILQSSTPAIVLRLIHGLENRGHTLWMDNFYNSPYLARRLKSLGFDCVGTLRTNRLFVPEALHNLTKNNMRPGEITGLTSREIDVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G963</accession>
    <name>A0A835G963_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR158/179 extracellular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000247">
        <property type="protein sequence ID" value="KAF9410761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G963"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="GPR158/179 extracellular" evidence="9">
        <location>
            <begin position="259"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="495" mass="57824" checksum="652A2F63129EB8CD" modified="2021-09-29" version="1" fragment="single">MVYLRYHFVFCCVGVAGQYEWQIRDAFDEIRGKIDKVSADNCFITHLDDLYLPEDSVSHHPDVKEININPVFPNRTAMLHLHNMAMNRAFFWSYILQSRFIRPAINDTYDPGMMYYFLSSVADVSANPYINASSIYFSPNMSYTSSYRGFFNKTMPRFAPRAFRADDFNDPVHLQKISTMNTFHVEDLGAFDPESLSKDYTSEFYRINEWYKKWLPDRVSKRHDTKTTYQVEIRYANNTNETFTFHGPPGNDENPGPVNWTRPYFDCGRLNKWLVAAVSPVADIYPRHTQFRHIEYPTYTAAVVMELDYDRIDINQCPPSLGNDRPNRFASTARCKETTECEPLHGWGFRRGGYQCRCAPGYRLPSIVRRPYLGEIIERATSDQYYNNFDCKKIGWVQRLPVQWERAHPFLRAMYMDRHYEYVNASSGPAALHTERVNVYEVLNFIRGVQPNNCSKYNPSDLFLNGDIAFGHEEQFENQAKMAVRLANFISAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9R9</accession>
    <name>A0A835G9R9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase family A palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9R9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.10">
        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF27">
        <property type="entry name" value="DNA POLYMERASE NU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="2">
        <location>
            <begin position="712"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="957" mass="105022" checksum="DC747AE33F758224" modified="2021-09-29" version="1">MENKTGTQPQQLPTRQNKILALHDETVVDFPQTQAGLLGVSAPSDNTSKNLLDINLENEAVSETNNNNNDFLHPIISNNENLLRTISDKNSSDKTFVEPKINELDINWDDMLDSELFVKMSADGDTDCKELHENYNIIDRTISEENATISCPNAKVRKSNNNATKSNSKLMVEIKQMTKKDFRKQKYTKTVKNWLDNVESPRLVCGNVDNNCSNEMPAKDSVLDNVEPNAHLTKTCDTPDKEMGPDRTRPVMQKTKKVVQAQLANKDGIMKYSKPNITETGARNESVTRQSTSKDSYGNKKIKKFVAPIKSQSVEDVKMQVHSVDEENVANYKDNLLQTKGTEIVAVLIYSNGFCQLNSHYTGDACSPSGVIICHNDMFYSFKTPGPRLKEGLGYLLSNNVVVCYDARSILMYLGSCLELHIGTIDMRDTKASGDTGWRHHRIGASLLDPDNPPENFSSVQRLLAPSPTSSPVTPGECALQRASWYMSQLKECWLKLSDMLKEHSLWEVFIEIEMKVLPIITAMELRGICVDMETLNSMEQAVAARLKAVEQRCYKAAGKVFQISSPAQVRALLYDDLQLDYRCNLSVRGTVAKGDKSTSEATVSWYQTPAGSHAAQLYQPLTALTAAQSGGSVAARAAQAGIGVPALAQGTRHLPGRHRAPCPQRSRPTDLMAAATGRIAASSPNLQAIPKAPYSLVLFPDSDDADAERAALALRACYVARAGRRLLAADFRHLECRLLAHLSADRALLRALRAPRDFFRVLAADWYCSRAPSDFMLKKPESEVVAEERERTKRLVYASLYGAGPRKLMEILGASYPRALQVAASFHSTCPPSAARPGPGGDGLTARCSAERVECAGSAADVCKMAMVQTARALRDGAAELVLQVHDELVWDVDARHLQAAAGSIQRAMEDCGRACGMAMALPVALRVGTDWAHMQPYTVSPATPEGQGLSSNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9Y7</accession>
    <name>A0A835G9Y7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_011118</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Large subunit of the RFC complex, an heteropentameric complex consisting of RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA and the interaction involves RFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000310">
        <property type="protein sequence ID" value="KAF9409553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9Y7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="311"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="898"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9409553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="961" mass="108061" checksum="FAA2A02BBB1A02BA" modified="2021-09-29" version="1">MSRDIRSFFQPKKPPKPATAVDDDDDVIPESPDVQIIKNKKKESKKRRVIDDDSDEEIFTSKKKKNESSTEKTGQTSSKNKSKSPKPALKEVKVIDMFGNAPIKRTEPLVKKKKKTELGIHSDDEFEKSLLEIDNAELEGKINDDKVSNDDKVKPSSEKATSSKLIEEPNKESKTSHDKKHKSTSEVKKDEHKSSKSEKAKSEESKESKHKSDESKESRHKLDDTKTKKQTKDDKKPNHTSTAHSNDGESKKSKIENSKRKFAEFVDDDVNEHALTDEERHERRMHSAALYKNYLNRSGPKHLGAKEIPEGKPDCLKDCAFLLTGVLDSFEKDEVAAAITKYGGCVKSGVSKKVTHVIAGEDAGPAKMAKAQELGIKIINEDEFLKMIVDRSQENHTSKPEIKKEIKQEKTLNKSKSKSPKDKKDNHVDKSRKSPDRIKPETKVRDKSNDSKKPEKFSPKKIKEEKVEASSSSTNRNQVNNIKKEVTAIPENTNMWVEKYKPQSIKQIIGQHGDASNVKKLMNWLTKWYVNRKAKLLKPSPWAKNDDGGKTTSVALVCKELGFDMVEFNASDTRNKTLIKEQIGQLLTSTSLSAFANGETGKQAVTKKHVLVMDEVDGMAGNEDRGGLQELIGLIKSSSVPIICMCNDRQSQKMRSLVNYCYDLRFNRPRVDQIKSAMLSICFKEGIKIPPDVLSQLIVSANQDVRQTLNLLSMWAIDPSRADPDSLRKDAQTTKKDIKLGPFEAIRKVFSAEDHKTMSINDKSDLFFYDYSLAPLFVQENYLQVAPHCPKNEVLQRISEAADSISLGDLVDARIRRNQAWSLLPMQAMYSSVIPGNRMSGHMTGQIQFPAWLGKNSRATKMKQIQLNKLLHCQVKAAMTRSYNKKATALPYAPGAVKKGRAKADDEFGEDDQEDEEETNDSDPENDALIKKKKSKDAEKPTTSKGKSTSKASTSKKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBJ0</accession>
    <name>A0A835GBJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_009856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000229">
        <property type="protein sequence ID" value="KAF9411291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="126"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9411291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="399" mass="44365" checksum="C17A5F075046CE14" modified="2021-09-29" version="1" fragment="single">APYIMYVEVLETDGHEPLPPRLLPPAPPAPHSPPIRHTKSEENLVPEWPALSLYSGLDDGDAGDCWSHDDEELTVSALSTSSCGSRESVAVGAGEVRRRLADATAAPPPNAFRHDPADPSATALKESWESKYARMRSSSPYGALSGWRLLGCIVKVGDDLRQEMLAAQLLRRLQAAWVAERVPLKLRPYEILCLDKECGLIQPVLNSVSLHQIKKQSGKSLRAWLELEHGPPNSEGFLRAQNNFVESAAAYALTSYLLQLKDRHNGNILLDSAGHIIHIDFGFIFSISPKNLGFESSPFKLTQEFVDVMDGENSDMFQYFKILILRGLIAARKHCDQIIHVVELMRMGDSAVSSFRARFHVGRTEPALAALVERLVRDALHSLSTRLYDNYQYYTNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC10</accession>
    <name>A0A835GC10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">cardiolipin synthase (CMP-forming)</fullName>
            <ecNumber evidence="13">2.7.8.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_007916</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="2.7.8.41"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.41" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000144">
        <property type="protein sequence ID" value="KAF9414038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000005">
        <property type="entry name" value="Cardiolipin synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9414038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="340" mass="38633" checksum="401637C80C1DB3F5" modified="2021-09-29" version="1">MKLLSRCNLIKHVSLLYRPNIKQDHVMCIREYVTVLSNTRQRIKHLPVTSVSYLHYSDDKKPFLTFEKKTDALKDAFEHKKVQFKDTEHRIRQKGEEIVRDIKHQKEVTGQKLRVKKEYIIKDLLETKAKVKERFEEVVEKENVFTVPNILCFTRIALSPYLGYTIIHEDYNVALGLLVFAGVTDLLDGWIARNWKGQSTKMGSFLDPMADKVLVGTLFISLTYQNLIPLSLTLLIVSRDVALVIAAFVIRYMSLPPPRTLSRYFDVTHATAQLAPTFISKVNTAIQLLLVGTTLASPVFGFVDHPALQALCGVTAASTVVSAISYLVSKDTYKFLKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC83</accession>
    <name>A0A835GC83_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC83"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="217" mass="23425" checksum="78EE32E3EC4B7E02" modified="2021-09-29" version="1">MRGRTLSGGSGQVCRPHFHTPLHPWLESKALSGGAWGSGFQQDAAQADKPLSPAQHHHPHPLFSFPPTPPKDSTPDSVAAAALGQQDYQAAVAHATAMSVAFMQQQQELPLCGDVKPMMGAPPSKQREGAQPDSCPQESSQPSGEYNAQYNAAGGDYYNYQGKGYSGQQQSKPRPNKTRTSAGESAVRTALHRSRCVHSHTPLRRAYPTTLQHYVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC98</accession>
    <name>A0A835GC98_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008817</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000179">
        <property type="protein sequence ID" value="KAF9412732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC98"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF84">
        <property type="entry name" value="CYTOCHROME P450 28A5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="496" mass="57192" checksum="2832812F4DD30D64" modified="2021-09-29" version="1">MLSVLLGIVVVVLTLAIYLKGIYNQYYWKKRGVAFYNKHKTGGPLWQFAIEDRSFFQILSDIYWKHEKEPAVGLGSFHDLGLYVKDTTNMQYIAQVDFHSFNNRGIAFTEEDVLAHNVLMLNGPKWKLVRQKVTPIFTTAKLKNMFYIIDKSAQDFIEYLRENPDKLKGDLFDTLGNYCNAAIAAAVFGIHTRSTFDSPFRTMAKEVLTPTFFTNLKFAISGVSESLFKFLKLKLFKTEKEKFFIDAMKQVIRQREKEKVKRHDFIDICVELQKNGTMVDPDNGYALEPTDELMAAQAYLFFLAGTDPTIAGIFGTLMELGRHPEILKKAHEDVDRVFEKYNGQLTYDAVGEVKYLYNVLSEVLRVHPPIAFVMRKCVQDSVLPVGNIPVEKGVKIFLPIFDLHHDPNYFPEPEKFDPDRFVREGEINDTTYVPFGKGGRYCVGARYAKIQIMTGLIHILRHYTVRSFVRKGGVQYNKEQFQVRLRNCDVELVPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCX1</accession>
    <name>A0A835GCX1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_000622</name>
        <name evidence="8" type="ORF">HW555_008988</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000599">
        <property type="protein sequence ID" value="KAH9634650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCX1"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF0">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9634650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="254" mass="29428" checksum="F21130568D99ED2D" modified="2021-09-29" version="1">MSLVEITEHDEVIYTILDKPPPEPPKTPRYESKLEKELREAKRPELRRTFGYAETPLKPPTEFLKKGEGIGQPVKKTDHKCFVSGNLPPVPKRPPPTKKQDKPAVNFKVINIKKAIKTKGKPVEPRLVDTRDGHIKKIKGSGEVPEFCLRPDFGQTPAYLIKRNRKIQKALEKMKYAEEHKESLCKLITAEERQKLLDDLKHNWSLMQKAFLQLPMLTDTIPKILRKTKMEAELRQLEKDIALVESNPYIYIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCY5</accession>
    <name>A0A835GCY5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009190</name>
        <name evidence="2" type="ORF">HW555_009541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000214">
        <property type="protein sequence ID" value="KAF9411750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCY5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27275" checksum="E62D4167A0FBE3EE" modified="2021-09-29" version="1">MTNRPSYAQLEGLVEFLEQNPGIAKGLLRTTQAKLETKRKWATLATSLNSLGGANKDGQGWAKYWAEKKCALKKQCAQLSSSMRLTGGGTASNLPTLSALDQRLVAVMGGHEFGNRDSRLAVDPFPELTIPTSPIIEMPVIETPVTEDTSPVPGTSHDDTPQPICLIPPATPTPTPVHSHHTTTVTIPQPRRRRSLIPRAQNADMEQFARIEERRVEAEIKTAEALAKIAEHMGTIGCALLEMSRKMPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDD6</accession>
    <name>A0A835GDD6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDD6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53399" checksum="149FF23D3C96ACA5" modified="2021-09-29" version="1">MGMLIKLSSISECYNNYFKSNFTFRLTKMADDEDEGSFGGMYEDGHWVWDEHTQALLFVSDLPPVNIEALQITSKAPTGTIEFRDDIDLIEQLRYKRRYQRKPTPGKIDLVTLQDVKDIALYTAPLSILSPMLIDMLHLPTTERFLRALIFCCAYYLQIAEEMTTRILDQATKIRTKRCEVLENQYRENLSDLRLLVAKEYCIMLIGGGDMRKFHHMGKDKKRRSLSDKDARLFETFLRISVQIVYLALGRRNFHQIELECHRVMKSEIFNTVEHMSKTGYLSKMAPEEKNVLLGTCLSHDKKLNTKSPLMNEVFCHRPIDFRLMGLGVVKYKRISTRLDYLYLIVAGPEEKLFELNMSVGLIGLQRSLFDTMLRPIIGQPTEKSKASVMSSKSMQRKSVQAPQRLYPEISLPPKDFIDTDLPSAFPAKPAEVRPVSQSQLKRWQKRYIRLTKPAAAARGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDF9</accession>
    <name>A0A835GDF9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000145">
        <property type="protein sequence ID" value="KAF9414010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49868" checksum="17517C256311F516" modified="2021-09-29" version="1">MIMFYCSQLSEEVQRKQSEYQKCLESYKQMRAKFEENYLKCPTSRGGRKLDETRDKYGKACRRLHRAHNEYVLLLAEATECERALRTAALPTLLDQQRRQGEATATSWKGVLLEVVQRSDFSTDKFREIQTKIETTIQNLRPQDEYKEFIEKYKSPPSTPVTFNFDESLVEDTSGKLQPNQLTVDNLTVEWLKEKLTELENTLQDNREKQSALQGPEIIGNGVCKNNNTGLTNGVNGIDRHSPPPLPVTTSEPIKLLELRVAERKCAKQAEMIRSALAELGCEEAPSGCPDLSAETVGVDSLDGSSPDHQDRSSIGSKASTDVLRLHLHSIIPPKPFFKLFTRPFRRKSAPSSPALPPKTYRSSSEGPADSVIIPHRRRIRVLRHRFRKRVDIYVHCRVHNKTLFKKRKPSRVVVDSCSNSVVSATNRDIPHPRMAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDS5</accession>
    <name>A0A835GDS5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_009053</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000189">
        <property type="protein sequence ID" value="KAF9412450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDS5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14126">
        <property type="entry name" value="STKc_CK1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000703">
        <property type="entry name" value="Casein kinase I gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022247">
        <property type="entry name" value="Casein_kinase-1_gamma_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12605">
        <property type="entry name" value="CK1gamma_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9412450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="576" mass="64865" checksum="45A40069BAF88626" modified="2021-09-29" version="1">MISLLTHIFHKDLKLCVHCCSATGAVGGRGVGGSSAMHTSRHSVTSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGTHEGVPKVYYLGTCGGRYNAMVMELLGPSLEDLFVHCGRRFRLKTVLMIAMQLVSAVKQFSAPSTAEGIPEVYYFGPCGKYNALVMELLGPSLEDLFDLCGRRFSLKTVLMIAMQLLHRIEYVHTRHLIYRDVKPENFLIGRTATKREKIIHIIDFGLAKEYIDLETNKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCEGHPEELATYLRYVRRLDFFETPDYDQLRRMFRDLFERRGYVDDGEFDWTGKTMSTPVGSIQTGHEIVVSPNRDSHQPFHKDDLCDYMIGLVEDDEAALISGEMAALAKTKDFGTGGTANTGGNWPHSGKATPLNTGHLTPADRHGSVQLLKNKHFRYVKFPGSVSTVVSSTNGELGADDPTAGHSNTPITQPHHEVDVVDDTKSVFQLYAFLFYFFYTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEB1</accession>
    <name>A0A835GEB1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033016645" evidence="2">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="216" mass="24404" checksum="15A1E66CEEB14D0F" modified="2021-09-29" version="1">MQGAVTNVKLLTCLVVYASSAHAIMVKFGTKDGPIVPPTPEPTPAPQPYRKPAPVWEERSNDTPDPNAQWRPPFFVPQPRYTNVIFNSPPPPQQLNNAQRFVNAYIPLKAVQQHQRGQVHQPNQPAILGSQSLPGIGLRYFFPAYVQEQNPAKQEDAKFNQIEGAHEPGTMGVDSAHDFQWKYEKDATRRNVRNSLESTVRAPVYQWPVYVPPRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEB9</accession>
    <name>A0A835GEB9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEB9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="169"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="476" mass="54496" checksum="CAFAF0969E976807" modified="2021-09-29" version="1">MNVPLAAHEILDALENVSDSEEDYRERLICILPPPVDPDCLTDEDSGEEDNVTLNNLPRNILLQPAEVMIQGQIMVSDTEEEPSDSTGRTKRRRTYAWRKRDLAKNPVNWPDVQGACQDKRPIEWFENFLDEDVISLLVSESNKYAVKKNLPGDITTEDMQMFHRHIVELGLGASVVLTFCDVLISRGFDLPYHVVFDNFFTGTSLLEEITKKGLRCTGTVRENRTSSCPLITSKLLKKKERGAVDYRTTHDNTFIIAKWHDNNIFSIASNAVGINPKQSDKRFSQSEKRNIVIEEPHMVSIYNKYMGGVDRSDENISHYRIGIRGKKWYMPLLTHMIDLAEHNAWQLYKINHGKLDHLGFRRRVANALIESNRKNAKRGPSRPSHHEHADSRKDQMNHLVIPQSKQTRCRQCHKKCLTRCKKCDVGVCVKLIWVKTLKKRIIRAGVVIMTVTVNSSASIIRSGNRALYARCDHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEH6</accession>
    <name>A0A835GEH6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_001045</name>
        <name evidence="12" type="ORF">HW555_007739</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000810">
        <property type="protein sequence ID" value="KAH9630817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000012">
        <property type="entry name" value="Putative transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9414342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9630817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="16129" checksum="2073E5F26DEE6A65" modified="2021-09-29" version="1">MSGKKCKHCGSSDIEVDPARGDAVCTNCGSVLEDNIIVAEIEFQENAHGGASTIGQFVSAETKGGATGFGRAFNAGIGQESREVTLRKAREGITALCQQLRLNQQCIDIACNFYKMALSRHLTIGRPSSHTQAACVYMTCRTEGTARILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEI2</accession>
    <name>A0A835GEI2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_015088</name>
        <name evidence="2" type="ORF">HW555_008729</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000259">
        <property type="protein sequence ID" value="KAH9640992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEI2"/>
    <dbReference type="OrthoDB" id="6432525at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="84"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9640992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="295" mass="34140" checksum="01ABBC5699033122" modified="2021-09-29" version="1">MSVITCASVEKEYEKLNNVKRDEIQNLMAWLKGVAHLPHEFITELDVILAYHSCALDADLTKRVIDVNYTLKTLFPFYQNRNVDASLDMALQTWLIYPLPTLTKKGFKSIYCELLDADPKKFVYADVIKAFLMIMDLWQYEEGTVPGVALIVNLDRVSLGHISRVNLTVAQQFFFFLQEAMFVSLKEFHFINAPTFVDKLLSMVKPFMKDELLDILKVHQADANSLEEFIAIEDLVKDNKSVLKDEMFNKLKANHKFFEDEAKKRVDESKRRDGPKTLSSFFPGMEESFKKLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEI6</accession>
    <name>A0A835GEI6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="292"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="446"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="93827" checksum="27E20347E8844A71" modified="2021-09-29" version="1" fragment="single">PFTRRLYCKKTSEEGGCETLETNSIETHGTSAAKSPIPNRVPKRSLKNIISRVDAKMMKFMDSFSNNEPKTMNRHLSFFNGILPSLDKYNDDEVLEFQMAVLQLMKKIKNSRQICEPSSFHIPSDHRGYFTQQYQNNIQEATNSFSTNMTTMTSVQSPSSVEVTTAASLLNPSSVRIAGFACYSNYTDQKVCQLRNRLKNFKKKEILNVITEDIAVKKFSEKITPAFSLLLKGQIRNLKKKVTGRRWSKEEKITALRIYKRSPTCYRLLRRLFPLPSISTLKTLLRKLPFGVGINKPIFTVLKRFAVTQAPSDNYYTLMFDELSIKKHLQYNPKYDIIGYKDNGTHGRSPATASYALVFMISGIRKRIKQPIAHYFSSGFSTADRLVVLIKEVLYQCFEVGINVAAIVCDMDGVNRRALTILGSTVEHPYIKFNNKEIVTIFDPPHILKCFRNMFIKYNIEMTTQISSDGLVGKGIVKWSHIKEFFRVDSTNPNFVYAPVLKKDHLDPNSKQKMKVNLAAQVLSHSVTGGMLARISNVNYRILVADMDKLFDLVNADSPDLRRGKPHSTNWSRTSPHTEFFKKMKEFFQTMKFIGCPRKPPSQDGWLTTLNAFLRLHKNLEAGWLPEGASRILSRICLDAYGVTVGPTQTLHVAGLKTAILSNLSHIGKSGNCENDNNTIINNFDTFLSFSQSQPTHIRTEIKFVIEDMPEISEEYIEEENAEIQACAYVCGFIVKKIKNVCKTCHKTFLTQDPMIACVECCATLINNILKKNGHANSLKTNITENIISKINLDFLNECLEHKQSNIEHIINSVFDICIKRFCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEN2</accession>
    <name>A0A835GEN2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEN2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF19">
        <property type="entry name" value="PROTEIN FAM13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="58"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="25238" checksum="2C04A46279D67734" modified="2021-09-29" version="1">MNAGTDKLYDILVLHLYGGKDIFITINGTYQRSCFGCSIEVLVNLNMPIKEVPVGKLIELENKRDSCVSNQSTYSIPKEIWFLVDHIYLHGLKEPNLFEQPGFHSEVLQIRDWLDSGSIDPIPGSIHSVAEALLLLLESTADPIIPYNLQSVCLRASANYLQCKQIIMELPEFRKNVFLYLCEFLQEALQHSAENGLDSKTLSTLFGAIFSGIIPTKHKNHSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFL9</accession>
    <name>A0A835GFL9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000135">
        <property type="protein sequence ID" value="KAF9414383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFL9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="81" mass="9144" checksum="9F6B059DF4AC7FDD" modified="2021-09-29" version="1">MESVNSLIPDDAQKTLIFFVNGKKVIEENPDPEWTLLFYLRKKLLLTGTKYGCGEGGCGACTVMISQYSKIKDSIKYPLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFZ7</accession>
    <name>A0A835GFZ7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="502" mass="55990" checksum="BD249ADB8B32D05E" modified="2021-09-29" version="1">MSTTYFIQASIAVTIEDLEKALDDIKKCRKTQKKAAEVYNIPHSKPVGKPPVLSSIEEDSITAHIIALADLGVPVSMLDVRLPVVAGKSVSVEAVEKYYQEREITTKSTADKRTLNTGTDSISGPVKKRGRPVGAKNKAVKKVTTIVNQPTSPIPGPSSTIATAGPSGMCVVTSEDVDNGVLMDPINHPPSPIEVIEIPTSMEDIEGSYENHNGILKKTDVNVQKDTKIGSASTDKDENTEGKENRKQNYCIVEYGDILFPGLIICREGVTAKISDVQKSQEGWKWPLKRDLITCLQSNIVSFLDDHKIVKVNDYYVVDDPLLFLSWTPIMCATPVGSLQTTRFNLKFQKKVQCNYLKTRKYHSSNTLHCPTLDKQLTQEDTVCFLTAGILRDTIFRMQYVDVTGDSGDRLSSLFQMPRRIVETLMNKVRDILAQEYVSQYLGLHHISRNRGFRDSVDAIHQRGFLAHLPKNLSPGQSQLTILEGNRSRCVKINRWVVKYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGU9</accession>
    <name>A0A835GGU9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_011211</name>
        <name evidence="2" type="ORF">HW555_007447</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000126">
        <property type="protein sequence ID" value="KAF9414751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000187">
        <property type="protein sequence ID" value="KAH9642618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGU9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9642618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="174" mass="18339" checksum="79D5A74828D8D1FA" modified="2021-09-29" version="1">MAYYSDSESDNEYEQVCTRGGCCGSEGAALPFDSASIENVILSISDSFDFRVILSDERTKGAILVTTGLALAGGLIGRHYGGRIGAAVGGAVGGACGLGIVAVSMRSIWQDIKEKLSDLFEMVYDYLAGLGLDDYKRAAMFLTQQGDKTQLAMLILETTSSILGKKILSSITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH50</accession>
    <name>A0A835GH50_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_006920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH50"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="284" mass="32112" checksum="4D25B1FEC6026067" modified="2021-09-29" version="1">MMQNRIGNLPIANENPLGLSWHDSAWIPLLSPSNIMDYFSERSNPFFDRTCNNEIVKMQRLSMDQLQNMTGLEYILLHVQDPILYVIRKQHRHSPTQAIPLADYYIIAGIVYQAPDLASVLNSRLLSAVHHLQCSFEETMSYSRYHPSKGYWWDFKATKPGLSPYNSGQSSSKDVSSTPKEEPSTLFQRQRVDMLLAELVRQFPLPVTQAPSQTNGVTVKSENSNEKNGDKAPDGNVNNITIKQEPADPSSSDMTNGSLQGHAEIKTEIKQENMKPPPEKKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHA9</accession>
    <name>A0A835GHA9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_006761</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000105">
        <property type="protein sequence ID" value="KAF9415662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHA9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9415662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="501" mass="58446" checksum="27F4958EE1E23D18" modified="2021-09-29" version="1">MGWPVPSAPRNIMYYIFVLPLLIVSLWVYSKWLSMKGYWKKLGVPHEPVHPLFGSMSFLQKKNPGTWMIELQQKYRSSPYVGIWIFWRRGLVINDPELARKILVKDADVFRNRMLASGKSDPMGALNLFTVDDPLWTSIRRRLTSVFTGSKLRGWQELYQAKVEDLIYRINSDNEKGIVIELRPLFADYATDIIGESSFGIQCQSTRDSTGPLRLMTKEFEKYNHWRGMAWSSIFFLPEMVDIFRFSFWPKNTVAYFRKVFKAMVEERGGFEKDIDGKRDLLDALLKMKIDAKKENQDMDLDILISNAMIFLQGGYDTSSSTLTYTVYELAYNPKYQKILYDELVEAEKALDGKRFDAEKSLRKYAIMGWLDRKALRDYQVDENLTIPANTVVYVNAIGMHWDPKYFPNPEEFRPERFLPENANNIVPYSYLPFGEGPRMCIGKRIGMNTVRYALAAVVLNFEIFPMDKFPLPNDIPIEKKGLFYLPAVPLSVEFRRRKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHI0</accession>
    <name>A0A835GHI0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Angiomotin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the angiomotin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHI0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009114">
        <property type="entry name" value="Angiomotin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051747">
        <property type="entry name" value="Angiomotin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024646">
        <property type="entry name" value="Angiomotin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826">
        <property type="entry name" value="ANGIOMOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826:SF14">
        <property type="entry name" value="ANGIOMOTIN_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12240">
        <property type="entry name" value="Angiomotin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01807">
        <property type="entry name" value="ANGIOMOTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Angiomotin C-terminal" evidence="8">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="368"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="557" mass="62072" checksum="0774A16256E95097" modified="2021-09-29" version="1">MGSMRPTGRFLSFANNIQRTQKQAVPSGFPQSLSGSETDVSTSNENLSREERYVVRHTARVEPQGQENQTQQNNNNRNSLKDNVTGSNRNSLKDSVGGGNSNRSSLDVSSSSYNTLIIHNQDDSWPPRPTPIREHERTSSEVKHPTTQSSPYHTLKKNEGVKKPSGIPVPKLHKEQNVTTTANYIDIGGQRIYTSPPDHGVQEITEIPDDFLNQSSVLKHLAKEVAQSPTPRGPTPPASPRAPAPPRDDSRKAKGKCSKTKLSKEKLNLSRSQPDLTSVGVRAVPGGSESSGWCSGGEGELEEPDDAFTAVLDALAAENHQLKRQLADACERVAKTNKLEEEVEKVRTAHEELVGSCERRERLERAARVRLQADCRRLHDLNRALKQQVELLSQGVRSENDSNAEALRKELQNREMLIAQLITQNKELACAKERQEIEMAAQRATLQEQRTHIDILDTALTNAQANVVRLEEECRHAAGYVERVLGLQRALASLQQASDRREHTERKLRAQLEKELQALRYNACSYCFNRRACSARWRRCSRRRTAASTPSASCAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHU6</accession>
    <name>A0A835GHU6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19116">
        <property type="entry name" value="AKR_AKR2E1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044488">
        <property type="entry name" value="AKR2E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032431390" description="NADP-dependent oxidoreductase domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="35634" checksum="B2A927803C7A4B5A" modified="2021-09-29" version="1">MRVLGLIFLGLNVVLATQPPCVLLNDGHKMPMLALGTGRGTAKETDTLDDVRNAVFWAIEAGYRHIDTAAVYGDEEQVGQGIADAIAKGIVTRDQLFITTKLWNDKHARDQVVPALKESLSRLGLEYVDLYLIHFPISTKADGSPDNIDYLDTWKGMEEAKQLGLTTSIGVSNFNISQIDRLLSNSNVPPAVNEFEVNPTLTQEPLVHHCMSHNIAVMAYSPFGFLVSRSRPDAPPPRYDDPTIGAIAAKYGKSPGQVVLRFAIERGLVPIPKSTNQKRIAENINIFDFELTAEEVAAISKFNKNVRVIEIEGWKDYPNYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIA8</accession>
    <name>A0A835GIA8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000057">
        <property type="protein sequence ID" value="KAF9418324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIA8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="8231" checksum="E6A0DC90211FB988" modified="2021-09-29" version="1">MMPHRAESAYIPLNQCGDKVQELSFVRTDSKEFKSVLRSDFVRSSFSEAERESLIRSDNSFIVSEHTFNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIE7</accession>
    <name>A0A835GIE7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9417008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039231">
        <property type="entry name" value="TPGS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="246" mass="27952" checksum="781321F2FC263429" modified="2021-09-29" version="1" fragment="single">LVSEDSFYENITLGVTKLLESDPRICHVNVERRSPCDRVALSTWEQRHSALLPEDLRNFYASSDGFQLTWHYKYSADEILPVGSIRVNSLNELCLSPALKDLLDFSMTRQQSGPRPVLNTKSKVFELDTCRNIGKICLVYTGGMWSVWLATREGAWGWLADSFTHYFRMALVHLGLPGWQAAFANLPLIPWAEQLFLLLAPHLLDKSDLDPNLITSASETGLNHIDPNIFKTSVRHHKNTTRQTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIF2</accession>
    <name>A0A835GIF2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">39S ribosomal protein L10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000099">
        <property type="protein sequence ID" value="KAF9415952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIF2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="257" mass="29175" checksum="EEC620F5BC3D6936" modified="2021-09-29" version="1">MASLKKVLLPTQAAFLIAKRFRGKINIQRPRKPHFERQLLIDLSKPKYGPPKHLLPDAMLCDRGEKLYAKVIDNPFERILANECLNWFNTSKMVIFLHVNAISMEDKMPVFAALSKNNMHLRCYGKKIVSMATTGTRYEAVNHLFTSHQNIIFGQPENIAKMFKIMKKAPQLVIMAGIIQDRLMSKNELLEYSQMQNIDVARSQLCAVLDSAGSSLVRQLTQGQQVLVGHLEKHVELQNTSSKEPQESTKTEPESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIH6</accession>
    <name>A0A835GIH6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Intimal thickness related receptor IRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000078">
        <property type="protein sequence ID" value="KAF9417072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIH6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032306698" description="Intimal thickness related receptor IRP domain-containing protein" evidence="8">
        <location>
            <begin position="29"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="9">
        <location>
            <begin position="339"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="93316" checksum="696B99193B6A2F46" modified="2021-09-29" version="1" fragment="single">IVYSNVGSIMTLLPGICFLVLVLPGVQAKWVEGRIDTKENWAFLARFCFLSLEGQFEYLIEYDKDAGIPNLLLYYDDDTQWPSVYHSSKTCKQREEVLNRAGQNQIIRLSHWYPDTEYSGCIITKHNKELPAAKSTTTTKATEPPVKKPKNSTKLTPPEPSYYDQFLKTTTRDPKVITDPNTNTTWFELQPTDGNFTTMTPEDELWESIAPGNGSQFGNLKDDVEILFENGNRSGHKIKRSLDLYERYRRRRLNAEPKALASQSEKEHLVVSCHNSRRFRSARERWWFIAISNCESNKGLDIRYKFLMTNGPDGDFWHEHFSADEFYVLPVLLAYTFAYVVVMIAVVMCSVELKSRHLLHSTYKLFLMSVVSQHSGVMLQSLAYIRYAANGFGTDNAKIVGQFLCGLSEMSFLLLLVLMAKGYTITRGRLKVGFTVRLTVFMCCYIVTYIVLFIYQAKAFDPGEVLYLYESPAGYGLIVLRILAWCMFAYSTFFTVRKYPEKNIFYCPFFICGTLWFYAGPLFILTANTYIDKWVRESVVTAVLLFITFCGHIMFLLLTLPVFANKNFPYHVRTTQIGVMEVTGNAALDGFGPNAYHPTNAAPQTVIIPLTRRTEELIGNMYNQYMATAPPLTLEDQPPKLKNIPKRIDSISPKHRLISQDSTDTNSSGDIKPIIQKDEPTKEIFTVENQISKMEPAVLPVPKPVPVLPERNLEDINRGDLPNVMRSRRNMLEPIKREDNVPSWSLAKGPCIVGMLKKTKNVEEDSPELNILTNGRKVPPVRNGLQSSSGEISTIMEGRVQSYPSAVSKATIDLFSVGSHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIK0</accession>
    <name>A0A835GIK0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_009750</name>
        <name evidence="3" type="ORF">HW555_005120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000645">
        <property type="protein sequence ID" value="KAH9633650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIK0"/>
    <dbReference type="OrthoDB" id="6922674at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="103" mass="12059" checksum="9C00ECE45D780D26" modified="2021-09-29" version="1">METLMDSIIDFVRVRQLNIALAGVLTLMYLIYQYWGLLFKSQDDEDDDDCQHTRLSRSRSRSCSRSKPRSGKNYDYKSGEKHGRRGRKSHRRCSDCSLCNFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ09</accession>
    <name>A0A835GJ09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000081">
        <property type="protein sequence ID" value="KAF9416928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9416928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="143" mass="15462" checksum="6FC0AECDCCDBFCCD" modified="2021-09-29" version="1">MPLSCYCLRYVCGNVYLPVGNLCWNVVLDDCVGGVLFINDISGVELGNNTMADEQGTVVELYIYDLTNGLASILSPSILGRQIEGVWHTAVVVYDREFFYGGSGITSCAPFTSKHVFRSLRIATASTGASCVAVYRKCTVQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKM5</accession>
    <name>A0A835GKM5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKM5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032652819" evidence="1">
        <location>
            <begin position="19"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="365" mass="37988" checksum="60C5A7852BE7F178" modified="2021-09-29" version="1">MNIGVLWCVLVVAGTCSANWQWPESEAAASVRIDTKVRFIDAEPDKDSDKVVRHVMFDDVPFKQPEETDGFYNRPPGAGRYPVRVEAHRAPYRSDGTGIYSANIQHKNMLSDGTLDSLQYCKCVSNADCNPRVDSRNACGAGKSLCCYPHHKNKLPFTHKNQYFNELEDDRPMLLPGQENLARPFPPPPASALNGLFGSFGPGHDHDSSHIGVFEKPLGVLVGPDGPTGVLGPQTKHKQPGVLVGPEGPTGIVGPAPDGTGSETAQGGVLVGPMGPSGLGSYGRGPLLVGPGGPTGIIGPARGRNPGILVGPGGPTGIIGPAYGRQPGILTGPGGPTGSIGPGRQVLVGPGGPTGRIGPQRFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKQ2</accession>
    <name>A0A835GKQ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKQ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63949" checksum="4057009A83681BBF" modified="2021-09-29" version="1">MSNLLNIKPANNNSASLNTFIESFHASVSALEQLKIKDLKDFMLLNLALKRLDPAIIHLFEMHMRDVEIPTYTDFVEFIKSQVKILDRSTSSRTALLSNNNNKNNSHRNQTRDSTDHWKLYTCPKFQAISASSRLDFIKNKRGCVNCLSATHTASQCKSIHTCRTCNKKHHSLLHLEQSSQPRSTSADAVSSSAHSQQVALCACSRVGINIPRTTVLLSTAQFYVDNKYNQYVSVRCLIDNASQNNIITSACCKKLQLNIIPLSNSVIKGVGTSSRPIIGYVEITVTAKNKTNSFKITALVIDCITDKLPSHVVDTSAVQHLFELPLADPLWHVPGEVELLLGAKLFPYLLLHNKILSPTAPSAVETVFGYILMDDSHCFLSLDESLHKFWNIEEIPSKSFMSPADRECEQLYVSTVSRDSSGRYCAALPFCKNPELLGNSYAVAYRRLINLEKTKLRDPALRATMRTVRQLSEDEKHLFPRASIVASQELYMDDLANSTPTVEEAKTLSAELVALFKAGGFDLTKWAILSQSYSFFLSNPTTIPQRVLDRSANEKRFRRSDTPRRQRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKU8</accession>
    <name>A0A835GKU8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="34" mass="3950" checksum="63F67AE6F0C0A2E9" modified="2021-09-29" version="1" fragment="single">MAATNNPYQHLLKTIEIDGKQFKYYDVTGLGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL23</accession>
    <name>A0A835GL23_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL23"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="428"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="555" mass="64001" checksum="24CA40E0BB6143A8" modified="2021-09-29" version="1">MENLRTVPASVEIMNEIDAAFNNFDDVIQNTEVIEMSDPSGLMEKEMEDEEQYQPEKSQEECAIDEDRRPIKRNRSEDEEGWIEVRGSKGKKYKSETIEIYISSQDKMPKQFALAKLFKEEGIKDIEKIRYINPYKIRVDMKNEDSVEILEKSRKIIENNWRIQRAMEVNFSYGVIRDIDIDLTEDEMLKRIECTEPAQLISVQRLMRRNSDGEGWKPSESVRLCFKGSFRPATISVDGLRIRVEQYIFPVTQCSRCWKLGHTTQRCPSTKIICPKCSGNHINCETTLFKCPNCSGQHMALVRSCPSYLKEKRLREIMAEYNCTYRRALTMYVPVKETNPVDSATTKTEQKDWSNSQAGKLSFSAVVQKPHVEVTTQPPEKDTQYNTAKKPQTKPHKPKQTEKPVEYETWIEVDAMDSQEIAEEDESDLNAHHTNWSYKTDTRGSQIHDALLESNFVILNDATSYTRVKLVNNVLQTSSPDITLATQDIAIRLNWATTNENLGSDHLIIRQWKDITIVPISKPNRNPQAPGSLRPIAMISCVCKTFHNILNKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL83</accession>
    <name>A0A835GL83_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_016312</name>
        <name evidence="6" type="ORF">HW555_003389</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000733">
        <property type="protein sequence ID" value="KAH9632055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL83"/>
    <dbReference type="OrthoDB" id="1868004at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9632055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34205" checksum="F55AD3C75BDE6FEB" modified="2021-09-29" version="1">MNNTTINVDQLNSALNSLRVLRSSVSHVFETLSNGLRADHGEDGKDKFLLELQELLNNVNINLRDLEQTVNGLPIPTAPFNLGTTTYLSQETTQDRQALYTQLVNSYKWTDKIHEYSSFAHTLLSQNSLKRSYINSGSTKRRGKLQSNHNVAPLLVDNVINNIDRSYSDMKITISRPFASNAVVQINLGHVLKAIVAFKGLLMEWVMVKGYGESMDLWAESRHHVFRKVTENAHAAMLHFYSPTLPELAVRSFMTWLHSYVNLFSEPCKRCGAHLHHTSLLPPAWRDFRTLEPFHDECKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLB7</accession>
    <name>A0A835GLB7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1401" mass="160782" checksum="98F69BA65615C203" modified="2021-09-29" version="1" fragment="single">MQIVFGHQVHRAFSPFIHLSSISTTCPVRSVLYQEPSFRDIKTHESYLVEATTAARLHSSKESGDPFVSSRKAYQEKIAVAIETLFTNFKKDGRERKTPDYIKRRLDSLDQYWSQFNNNHITLVNVGDASLHYFSSERETIKNYLLPKSTGSEERPQTPILKPPSFVLPSAQEQDRASSSKTEDMLKKQLSNFKAYMRTVSSINVELVSEKWEFEDLLRTLQSRWSVIDKLHWELDSELSGSNSEYEQEFSKYEAHYNNIKKTINKKMWSVAHIEKTTPKMDIPIFTGSYSQWIPFKDLFTETIHRNPSLSNAQKLQFLKGKLRGEPERLIQHLQISSSNYSLSWAILTNRYDNTRLIFTAHANTLLNVPNLQQQSANGIKRIHDVTNECLNAIKNLDINTESWDPILVLILSQKLDTDTYQDYMESVKQPRAIPNLKEFLKFLETKFTTLESSRRKQDNITQKSSSSDQHQATGKNSNKPHQKLNYYKTSFSSSARVFPSNSMGNKNMKNFTPNKYWCFICQNNEHGIYFCQKFLEMPPHIKKNVVDKNNLCYNCLHNHYGQPCKSEKRCRECNKEHNSILHEAFQSNHMSTRRTRPEASSSTATTEQQASSQVQGSSHVSLQGDPIEVEAPDVLEESFYMDDLLHGSHSIESAKQMQEDLIKLLKAGGFNLRKWKANSSALLDEVICDQENFDFKQKCKQVNVAMIDNTFITDLINDLLMKYSSMNKAIRIFAWINRIVCRKSTNYLSVDELTQSRNIIVKVNQASAFHDEINCLQRDFQQKIPHSKTKPSSFTKVAMSLLLFLMAIAPSSQTVYNITSLQNNNSIYFDSITNMHLIRDNWRLVVYYDTTPYQEGNTTLQKYIDYLEKICPLIKMESHCKAIILQLRHGLRNIQVTLLDTITNIYNGRFNFQLLRPEQLRHELNIISGQLPRDLSSPIDSFNLAEVYNLLQIRTRMSPKYLIIEIKIPLIGRDMYEIYRLILIPYLKGNQTTTVVPISEYAAINLKKDALISISESDLKQCTRQNINLSLCYLRKPIYHIKDDQNLCERLAGTRMCKSTTSSCGNMWREINKLNEYFYFCCEQCHMKLLCGDQITAVQLTGSGLLSVNAGCIIKSEDFLVFAHRSGTSKIMISSEIEAPRIAPINHIINVSIPTSVQLDSTTHSDKQLQEIRAQIDIMKDNTPIIQTVSTHDAHHYAAIYIIIGVMLLTAIIYVMKRVRVRRQQTLQQAAAEASQEQSLPVATTAAAGLQTVSYKVDNQCSKCASVVQCSEKAGARIIKQNSSTSPILRSIVFGHQVHRAFSPFIHLSSISTQESRGRRSDGQRGLAPRAQLGAVVGQHAAGRQRHAGQVERRRRVAQRQQRRQHHGRALGRRRHGVRQRRHARQHAERRHGLQPRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLE5</accession>
    <name>A0A835GLE5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_013160</name>
        <name evidence="6" type="ORF">HW555_003491</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000654">
        <property type="protein sequence ID" value="KAH9633483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLE5"/>
    <dbReference type="SMR" id="A0A835GLE5"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031372">
        <property type="term" value="C:UBC13-MMS2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000015">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9633483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17212" checksum="C53EB60834696FEB" modified="2021-09-29" version="1">MAALPRRIIKETQRLMQEPVPGISAVPSETNARYFHVIVTGPEDSPFEGGLFKLELFLPEDYPMSAPKVRFITKIYHPNIDRLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAELWKVNESEAIRNAKEWTRRYAMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLV0</accession>
    <name>A0A835GLV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tethering factor for nuclear proteasome sts1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000002">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40270" checksum="832F6EA222029570" modified="2021-09-29" version="1">MTPMEGAVTPDGGRRTRAALAEIPVRLDRLRVTPLQPVTNIRERSPALPAGYLSPAPSPDELLIQQRGRKRLPVTWSPDIELKRNPAFHSAVRTPPKDNHLSPHKLGVTLRSTPRKRLLLDTERIPLTPEKIDFSDISTPQKFKITSPIKSTPPIKRCRLDRSLNSEYKGPIDTALKGLSPTQLIHMIKTITYKHPEIEQEIRNDMPAPDLSPLEERLSYLKSNIFKSLPTSRLTSKTDSPAYSRVATHLAAFKKCVVEQGKVLVESQHWESVLQYVFLAWSYVKATPLWDNQPHNAQRKQCFRALTTYCMTALKKGNLQKDVLADVQDKLEGMVADSEEISSCLKYVQGQLQEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMF4</accession>
    <name>A0A835GMF4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="51892" checksum="85A3C60F79E595AD" modified="2021-09-29" version="1" fragment="single">QTNPQEERDDNYLQALIEQSQAWLKNWSDTVEGCVAKADQKREQQRIKQLATIKEFANRNVGKNNAEVIQRARQQIFEESCYGKKLVSALLESRVQEEREAQINLKKEIKQKQMELELKKAKTVTFCTFDLDKDEDTVKEKRKSIEIENSKTNKEMFEKQKEQEAKSNEKRKQGELKDAQLMKRLLELEDEAATKMKLLEKQALEQCAAEYKKTKDELAKWEAEYLAKIEACRRDQEQLNCQIKKVNQQIYKEHQDTEIMKINYNTTKQLQLEQKKQFDDFIEKYNKKGEHRAAKRERRNKEKTKQDRKNNKTIAEFNKSMAEAANQWKGINKCYCDRQCYIAKCEKPRITKKAAKETVDPSVKAAKPLPCFQPQRRLIAELRRREKEPSPWSGSETLDLQFFKNAERTLSDCKNKIPARRVIDEYRKSNGLNRSLNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMJ3</accession>
    <name>A0A835GMJ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMJ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07443">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HARP" evidence="8">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="453"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="72897" checksum="E8D5B2B1099E4A6D" modified="2021-09-29" version="1">MSEEIERKRLAALQKRQNLLANRNTPVKTNPAQGGSPLPSSSNSVFKSFASSLNRSHPYAKPKGPESVQENKVPIGKVVTGTVYLISEDRFEVNPSEFCTPLINIFKSLPSKSYDSKSKLWNFSINDYQQLMSKVAPLAPHVVLGLIPPYVLKVLKEDAMDPSCVDLTPIEVTLRHKLMPFQVEGVKFGISRRGRCMIADDMGLGKTFQALAIASYYRHNWPLLIVTTSSMRYTWQSKIQELLPSVPMMNVVTLTSGKETQLIADKQITSMYTDLLKSKKFGVVIIDESHYLKSHKAQCTMALRSITRQCARAVLLSGTPALSRPAELYTQLSLIEPGFFTSYTDYGKRYCDGKQTNFGWDMTGQSNLTELQIILQKRFLIRRTKEQVLTKLEEKTRETVLLDQTLLDYSQDTEKNLSEMANAYKTSKSSDKQTALITYFSESAKVKIPAVKYIRELVSSEPASKFLVFGHHRAVIDAVCLTLDEAAVSYICIVGSTPAGARAELVDTFQNSPSCRCAVLSITAANSGITLTAANLVLFAELHWNPGILTQAESRAHRIGQSARVSVLNNVGLSKDTFEDNTLKHQDSENNITQYLTPCMTKNKNDYVPGTNIRKDSMKENENTSNDQTSVDDVDRSFLDDDEDDELLANLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP40</accession>
    <name>A0A835GP40_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP40"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13647" checksum="F93DF52F65E658E7" modified="2021-09-29" version="1">MITDMQLAVFSNFVGVSIFLLVILYHYINVNSNTNVLKLMGNVIEPTLNPNGGNALVATLEHSSLRVTPPDCCHLSMLQRKSVYIPKGHRKQSRSASISSRLGWRTTVPPDKISVSISMHAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQU7</accession>
    <name>A0A835GQU7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_007709</name>
        <name evidence="17" type="ORF">HW555_001180</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000075">
        <property type="protein sequence ID" value="KAH9644612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQU7"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9423371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9644612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="17351" checksum="B6CC38D0517F89DC" modified="2021-09-29" version="1">MAQVPLYGVKTHAQKVCSLYKRALRNLEAYYDRRNVYRYQAVLLRDRFDKNAKVTDMRKAVELLKEGEEELFLTQHPIPRAFPTSQGGVAHARVVTPPDWVIDYWHPLEKAHFPEYFKRREQRKKEFIAMWEKEHGPAEKKEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSV3</accession>
    <name>A0A835GSV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">unspecific monooxygenase</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_001401</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9423097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="465" mass="52996" checksum="1DBBAB81292446D5" modified="2021-09-29" version="1">MFFESFLLNLSVIVVLIIALIIDYVTKFFSYWYVRHVPYKSSIPFFGGDYHRVLGIRSSTEDANILYAQHPKDKYIGRVKCRIPDLIVKDPDTVKRMLSTDFANFHSRGLFLDKSQDVCLRDNLFYADGEKWTLLREGYDSLLSNINCELESLSDCLPGTNGDANVQEILSKVLDKVFEDLLLGSGGGSVVKEVRSAIQRRTLIERFKSYLKDIFPSLYIMFGLTTIFGEPSAKTKSVIEKSKVLSQIKKLGTVYQLGIKEKNKKPHSDVEFAYSIISSFVTEGYIPCLNALTALIYELALNPEVQEKSRNSVAKHNRDEYLDVAIKEALRLHPPYSIISRQCTKTYHPEGGILIDRKITINVPVMALHRDEEHYINANSFNPDRFLDDEGASKHCYAYLPFGAGPRKCIGEQLALKMIKSISKAILNKYEIEPCAKTPSKLTMVDHNFGRVVDRDIWLRFKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU55</accession>
    <name>A0A835GU55_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU55"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="77" mass="8938" checksum="DBDBC56DEE6C7510" modified="2021-09-29" version="1">MSQDLVVMFVNTVELCKNAITETYYAVVKQSLEMSSDISFSKIRICMVAKNKKPTKKDRRILLQSCKWKTMSLEEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUS0</accession>
    <name>A0A835GUS0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUS0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64720" checksum="BDDA7A3B51DDE2F2" modified="2021-09-29" version="1" fragment="single">VHITEMLDLLRRDVNNTIDFENVEHMNDTTCRYWTGLTVLNFLSILTCKPQLSNICKKPKTALGMYLIKIRTGEPFRRIASLFRLSTYTVCQYVKKTQNNDIGLLTSLGFSVHKPETLDVGETQLFTIKANKSRLVTLCRWVIELVNGRFKRDFKGSPLILNENRSTVPLVFVLCTNKDKTTYNKIFDLINEYFCDNDIVINVKYCMMDFEITAIQCARQNLENIMVKCCSFHFGQIIYRKIQSSGLAKLYGTDYSFSLEIKCLMALSFLPHSTIPQYFKVWEENCSEKSALIAKWFAENYVVGKNGKLPQIPPSLWSCHDLNHLKLPRTQNNVEAWHHRLNSIVDKRSPGFYELSTILLAEMNIVEGKIQCILNGEPSAKQKKICTKKNVNIETILRNFEMYTELDLLKAIATSRNLMSDFRICAAILNDFHPLIIDRSDAQAILDRAMQRLNLPNYLGDYVLEHQLNRRQASFIRIDDARLPQINIFPVMEMSDLIFFSIGVYQIKQARSYYGEHIRANGTFSVEISENLEITDVPGITSSHETVLLRGRIRSRHQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXE5</accession>
    <name>A0A835KXE5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000558">
        <property type="protein sequence ID" value="KAF9406707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXE5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127245" checksum="3A3E37CC9458BFF7" modified="2021-09-29" version="1">MSPKKSVKKQQSKRNSTEKQPNKREKPKFNMPTNIKVSIPLRKKIGNSDEGIHFPIVRGKRPPQFKKQLDTKTQIDLANTVARQQLIKEEPPTFQLDNIVIIQNPKTKGRKRKITDFFDKDVAMDPSDNNAENVVSSTDTKSQKTEKKVPAKPTITRRIVTRKRLADSTANSQQTTPKKSKLDVKAQKIDIKPEKPNVDDKEIVVPDSNPIVEQQDKPAPKRTKPGLKLLRSRANNPAPKCRAALRRGPKGKQEIAVPANKPPPIPDQTKKMTKKDTQNENVHQYNSAPIDSRKTSVSSCSNLSWTKDISSSSNTTCITACSNDFVRINKKLPMLVLKNIDNELKDKQVSKIQLKNHTEPIAPAAVTDSDDSSSDSSDSDSSDSESNDSESINDIIDANSLHLSTSSQPSGHIPEYSDKQNAQDYTKISDTLIMLVDKLDMEIINWISSENEPINANLDKFKDKMFDILDNEFGVITHCSRLKRILDPDYSEDAAVACIPKIVESAPVENVTVQRDTQPAPSKESTKAPEKDLVERRALRKLSINLENYASNANAKVPRDDYLESEIQAGTARNNSAYDHHDDDDALSLFAESITGFESSRMNASIVSFPAYKARPVEEYIPKPVTEISTPNVERHTYLPTKIADAEVTASKIASVIEKQNADSTSIYKQSNSTDDAESYEDLSENVELNPKVGPPDVEKTPRLMDSIIERTPRARSIVFSNLCFYNLLNCCRKVYSGQCRFLHVIPTCEQVKAKLGLLDERLLIQEYMLLRNWTEIRRRFGLCYVEECAKRGLTRILVEMAYDFIVKARNDSEEDAQIRVNTIEITLLHLNTVDLCICEDLLKMPVHTEQGNRILLCDVFMATMSITQNFSRFKLVFLTLTYFMVDNDRTFNKDVVEHILERVCILPFEEPIAKALIQMMRLTNGAIFSNSMIGMFEKQISVNKDVLEEFMLLKSQYAFSSMLASSMIEECSQLKVDQAQSVQSDAGDGQPPAASPDTTNISNLHNPPSEEPPVPIITRTIGMGPPITFSHSPTKSGSSHVQESPGGSRFNSSFVSPNNKNTNNMKHWRDRSIFDNILRPPTTTPRSHMMRPPMLPQMRPRPRPHFNQRLVTFRSPSRYVNRQPGPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXT4</accession>
    <name>A0A835KXT4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000732">
        <property type="protein sequence ID" value="KAF9405479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="117" mass="13609" checksum="0D0E973766891D32" modified="2021-09-29" version="1">MVRKRKFSAFGGKRRYKPPKIKKSKFSKSPRKSISKVTPFQTRVHTSFHVNLPSLNGDKFTNALKAIKTMKPTRSGISVKLNNVIMNIRSLTKFRRHYKLKRVSDEFVFMPINIQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY00</accession>
    <name>A0A835KY00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000676">
        <property type="protein sequence ID" value="KAF9405817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY00"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="260" mass="30144" checksum="C515B6059C4E5BD7" modified="2021-09-29" version="1" fragment="single">MTEFNWDDSAVLLLIEKYQENELLWNPRHMDFKNRNKRNDAVRDIASVFNIASSEIERKLKNLSSHYFREKRKYEESKRSGSGRDDVQLPKWFAYKALSFLNDKNAPVPTLNSLTPSSSQDNITSQTTLLSTRTSRKRNIEREPEVDEALQLLREITSNARQRDDAAIFADYISSKLRKMDHYTMCTVQHQIQNIVYEAEMRMGSMNFDTNNTTQPLRYQNVLPGYFTGRPTTSAMSPSPSTSRSVQSDYEMQNSPDVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY74</accession>
    <name>A0A835KY74_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Squamous cell carcinoma antigen recognized by T-cells 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000411">
        <property type="protein sequence ID" value="KAF9408043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF25">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="78726" checksum="19720CB6089AF39A" modified="2021-09-29" version="1" fragment="single">DEVRNESEEENEIGVILAEEEADVGDDPDDSEIESEEDEDEELILEKRVLRLESCIAKNPYNYDEHVDLIQTLWGLSSLERWRAAFDRLQQLTMLKAEHWLMRLQTEVSLAHNDEARERVAKLFQDAALDCYSIPILSEWCSWALTVEPAEKAREQLDEVLRRAGADPFSGKIFWDAKLELEKTQLENLSEEDTEYKAQKERVLWCLEETVSRPLLRGEEALQQMEAIALSLHSQDYVDKVKRQHEFAVDFLHQISPFEDRLLTTDNPKEKLKVYTEYIKTLKNLALDDRYAECDSNGILRVVYERASYECGACGAHVYRALATHVRTHSSRATYNRLLAALRRRVPTRALPWDLTMQQAEKEGESFEQIKTIFETALARGMESFSQSEELWLSYLEYLRRISDFNNEKDVDRLRRTFRLAWDTLAETYNEEADDSEVPIFWARLEYKFLNDPKQGRMIFEEILSLPNKENPLQTDVGDNKTISKYWEALLALEFDRKPRPSDHKLRELMKRALREVQDFPPVIIRMWTAFERDHGHIESLQECKEICELKLRDWHRAYESMRKKILGKKPNPGNSKTKMKPKIDMLVKGKGKRKSDGGDDGGDTKRKKEEKMEVDEKEDGGVKRSHEDEDDDAGESKRQRTSSSSPHRLGTRDACTLFISNLEFKLVDCYLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYX6</accession>
    <name>A0A835KYX6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_013164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000585">
        <property type="protein sequence ID" value="KAF9406485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYX6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03356">
        <property type="entry name" value="LbH_G1P_AT_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="479"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9406485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="646" mass="72313" checksum="B1D818FF7BCB1102" modified="2021-09-29" version="1">MEIDKENVVQAVVIMDTFNNHFSPICDNKPMGLLQVAGIPLIDFALESLSHGGVGEVILFCCKGGQKIKDYVRSCIDNKAIWSVTMEVQVMMSDTCQTMGDVMREIDAAGLIRGYFVLTTVNSISNIHFGSLLEQHKQTCKKDKGAAMTLVYKKVSWEHPLIASDKPTFLAADANTKKVLMHQKYKPKSTEKSINLPLEIVLNHSEVKLHHNLVDASIALCSPSVPPLFSDNFDFQTRDDFIHGILINEEILASSLYYTLLKGNQYAAAVTNWKTYQTVCHDVLHNWTYPLSIDTGLSYQNTYFDMGNHNFRNKNSTLSRSSSIVENVLIGSKTVINDNTVVTKSMIGKKCVIGNNVTIKGSHIMNNVVIKDNCNIVNSFIDDNCTIEENSVVENGTIIASNVVVQAGSQLRGNILESTEAEREKTLMKSTSESTEWENESSGSGGDDFIGFEKTWSDSESCYSSDGSDESSLPDSPIPEDTNIFLQEVIDSLARGYEEKLKNDYLILEINSSRYAYNIQLHEVNFFVVRALLSIPVLAETKNVLSTVKDILKYFKPVLSNYIKTKSSIMDCLRAVEDSCIKCQWLEGKCGQILHLLYEADVVDEDSLIEWRQDLEENESPIANQPSLVKFFEWIEEASEESDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ68</accession>
    <name>A0A835KZ68_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000308">
        <property type="protein sequence ID" value="KAF9409588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ68"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="279" mass="29808" checksum="654F03E7195EA4D2" modified="2021-09-29" version="1">MPQKTEILSNIGQTLERYKFTYLSSCVDSQHHVKFVGSKRDVSATIVANSDTLACAVVTALLTRDDVTIPVVVVESNEANVSSAESNLVATVVPPVGKSGVASTVSEGNHAVDLAPTVLTDPSVTAALVLVDRRRDDVAAAVHWGSSLSIVEVERAHQLWPAVRMGQHESNSTLVLFRLFVGKDGSTSTVTSLVVVVVNEGKRVARSKKTPSSSPVMKPSKLVSTVESSAEFHTEFELCDGSKRSVFIAGNDFTTKINNFLVDVWASARGETVISVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ76</accession>
    <name>A0A835KZ76_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000845">
        <property type="protein sequence ID" value="KAF9404969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="entry name" value="Glycerate kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="entry name" value="Glycerate kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00045">
        <property type="entry name" value="glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="Glycerate kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="38584" checksum="955D371DE7EA5BEE" modified="2021-09-29" version="1">MKGSLSSITANKVVGEVFSKYGHDITQVAIADGGEGTVEAVVKNNNGKKIAVDVHGLTNQQISADFGWFETEKLAVIESAAASGIQFLDGTQQTHPLNTSSFGTGELILAAVKKGAKTIVVGLGGTGTIDGGIGLLSALGVEFFDKQNRPLPAKGGSLGKIEHFSIKNLPPKLGTITFVIASDVTSSLLGDSGAVYMFGRQKGIQADQLVAYEESMHQYQKVITGKNEFVEGDGAAGGIGFALRVFLKGRTYSGFDFISEQIRLEKLIQASDLVITGEGKMDNQSLQGKVPVGIGRLAKKYHVPVIAFVGSFSGDELLFAEEGVSVIMPIIDDLTTLEQAMINAEKNLRKTAERTIRLLDLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZF7</accession>
    <name>A0A835KZF7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_013820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000740">
        <property type="protein sequence ID" value="KAF9405443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZF7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9405443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="96" mass="11361" checksum="BBD8A985171CBFFF" modified="2021-09-29" version="1">MKIDGGDCVGESFSNEDFDNSTVHYAFNNETKKCQEFKFVGCGGNENRFDSRQECWRMCYTPLKYFLTRVTEYLIYRYKDPLNKTNTTLHNSKQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZQ7</accession>
    <name>A0A835KZQ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000367">
        <property type="protein sequence ID" value="KAF9408697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZQ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="445" mass="51711" checksum="415B2AA416F03D44" modified="2021-09-29" version="1">MKCAERDGEVLTTKKLESLAAYNQIMLPYSLIKIKTTDIFDIDIKKETDLTLKEEIDYSDEEPLANKVKKNKKYEDNSVVNEIEANCDDDRSDFDLQLDTQDCKNDVSNFDIELKCLTKEEQYNELLARKSSQNYINSFYKCELCFKGFLQDETYKKHMIRHDPSSGDETCDVCKTRWPNKRALKSHITTAHERKYICKLCNLEIKSSHRAKEHLKWHTGHRFICKICGLTFSKSTSHLTHVRLHHPSKNCCGICGESFLSEVGLRMHCKKSHREVEVSVVTRAKIVCCVCDTHFKTVEAMKRHVAHTSDGVCDAKYRQFAHSRSFSIHYQRVHLGIKLQPYKPRERRAHVDWIHQRTHTGERPFKCAVCPKAFKHKAALNRHDRVHSGAKPYQCVHCGKTFSQSNSRKLHIRTVHLKLPTPYRSSRYRTEDTDVLENNGLKLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L174</accession>
    <name>A0A835L174_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008994</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the hemolin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000557">
        <property type="entry name" value="Myosin binding protein Ha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000999">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001053">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001166">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001452">
        <property type="entry name" value="Uncharacterized protein, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF3">
        <property type="entry name" value="STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="285"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="404"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="629"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="729"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="846"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="945"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1155"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1302"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1252"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9412525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1426" mass="161539" checksum="23A77BF9F3E08305" modified="2021-09-29" version="1">MRETERRIREERRRDIEKDLFDTKQKPSTSRLEPLSESRPRNGDIFVKRGTDEDHYIKEYHYEPTKERSQDRSKFVDHNHRDYTMEFIRPSSYREKTFEHERFSERESLGRNATIYKAQTIILDSQLRSSVPPLPERSESERRDRFDRGESERRVDRHRSKALSEARSLISEKRSSVSRDLKRKPVFSTYLTDRTAVEGSRVKLTCSVLSSSDPKITWYRNGILLENKLKYRTKFIDGLITLEVLNAVVSDSAEYSCTVENENGSVNTSANLKVYPSFEASPIPPTFTRSIRDTYHLAENELVLECRIRGQPLPTITWLKDDKPVSNNERYQAYYLADGVCRLAISSPTPEDSGKYTCKAENSVWSDQITHVVNFTGKESRLSPNIATIERSRFNRQAMESRRPHFTNVLSDYKVAKGGTIGLQVEIRGCPTRVEWLREGRSVTEVYRNARTFVEQGLYTLALSDVTEKESGMYTCRAWSTHGNVDMNAAITVVANEVEGKPAIIAGRPDKDILISVGEDINISFRVQGEPKPKVVFMKGIRDITTSQRVCKMTSDDYVKFTLKRSVVSDAGTYCILARNAYGCDRAFVTVVVRQRASSDNLISDWTYPMDDSAVSVAERKYKSVPDRIPGEPSVVDGGNNWVSLAWPKADPRDTAPVLAYKIESWLLGKEGGARWVELGITPLNSFDAFNLKQGEEYHFRVTPRNRYGWGEAVQTSSPVGIGLAGDRPEFVDILPGQLKVLAGETANLSCSVKGKPLPEIVWMKNGHEIEEESRVTTLYNGQDCSLTIKDICIEDEARYSCEASNVHGRASTYARLAVVTDRLIWEADAKLKRERSQDAEGDYPPQFTMRLRDRRVQATYPVRLTCQVVGNPPPTLTWFKDGELLVFDSRRTNYQDEHFHTLEIAPTTLEDGGFYEAMARNSSGAVSCRCSLVVDKGIRAYVAPEFCCGLEPLYRLSEGEELRISAVVEAYPSVGVTWYRDGVRLRPSRRAIMTLDRDGQIELALAAVTGRDAGVYTCTASNEVGRRPRQGRLRYSKEPMFIRKPRSSEAREGDTVIIACEVIGDPKPDVYWLRDFLKPDYYRDATHFKRVGDGPEYRFEIPHAKLDYTGAYSVVARNVHGEAKAIISLQILAKDPTSSDDSHNVRYGRVDVIPRFERELTDLLSYDGDAVEFECHVSGNPEPDIRWFHYNELIRDCPDFESTFEDGAARLKIKQVTAEDEGTYSCEAANNLGKATSSACLVVYPPGEPNTLSQRLRRPPALLSAASTPRSTPRSTPARSVSRTPGPDPRRLCSPSRQMAPSFYTYPFNKVVEEGDHVTFKCAVKGQPSPWTTWDKDGIIITPSARITMKEKDDMLRILEIEQVSIEDVGIYRITIENEFGRAEATARLEVITQKGKFYGGVRAYSASPRKSLSYRRYPSVPRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L191</accession>
    <name>A0A835L191_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA guanine-7 methyltransferase activating subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000238">
        <property type="protein sequence ID" value="KAF9411023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L191"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106005">
        <property type="term" value="P:RNA 5'-cap (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028271">
        <property type="entry name" value="RAMAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15320">
        <property type="entry name" value="RAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="13311" checksum="70DBCFF5641D65AF" modified="2021-09-29" version="1">MAADTLSAEDKEFLAKCEEELKDRFTEKDVDFMKVYNELPSTPPVLDSWWVPNSGRRNNDRRANRRHNHYQRDNNRDRNYGRRDNRGYNDYSHYDESSSGYRPRHRYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1L1</accession>
    <name>A0A835L1L1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1L1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20235">
        <property type="entry name" value="PFM_spherulin-2a-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="318" mass="35480" checksum="10B269B120394D52" modified="2021-09-29" version="1">MRQILYKTQIIRDSMAAASSVVLLLLPVLTLANIEVDITASDEASQQNLLISGANEAIISDLEVQTFQLTEENLKKSVENYFGHKPDDVFLKSPTPWGDLYVTYKWKQVNRLLKPLGAKILSVEFKPFLVLSQSFNNTSSKPSLFKAHLTQNVENTISSSWEKYSEISDSQDIKYGFDIKAMGVSGKATFYLYSKWGERFLKFQTVTVGSQSGLDISLQPGQSAIAELIATRGVMKIQINYAASLTGIVAVNFADLYKGHHFWSLDVNKMLTAGGLNKTVLSSELIDFAFYVKSRVDLRDLDTNETLASVPLMVFNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2Y0</accession>
    <name>A0A835L2Y0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000186">
        <property type="protein sequence ID" value="KAF9412524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2Y0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="738" mass="84575" checksum="41F6014C4E418FA3" modified="2021-09-29" version="1">MYKVRAFSQKLRQALNEGSNSSSTPENAQESCYQLEPPINELPILRNICIQSVPDSVAMPEGRPLFLEMSFINMYPLNDLRMEWSIGSEMFYRSSFRQRGQITYARLVIRRTRLKMTGKILGFLSVRSGTNSELLAIVESSCVIYDFRYKKTHFDQILSNLIHLGSDRKHNKFIVLLNKWLFAIRITLHESVVYVQKPTPRVTNRLELRSIMPTTRPGTPSWAYHYRALNIRTAKRAIKIYGFNDMDSCNASGEDASSSSVHQNYSLQSPLRPEIRRIRRLLPPIPRFVIPRYGPSRQERRGPTNFTPVPGSWSSPRETVQFTTVRRRLLPAPTRTLFDPHWPDRQERHYASVGNVPAMSRSPFPREIDQRPHRRQIPPLPPRRRLLPPPSRALPITQETEKLRQTIVKRPQNLNHELIPAVPARCLSSRDTELRSRHLQSTPTRQRATSSLNLASPRSQDVLKRFQPRDLSLTSTTSTPSTVRCISPLNNIDSKKPKTPILDTKYLYHRPYRDKNEDESLLQKDEPNLKAFSPSSLNDVHEGGENLRGLVEAYEQSQIDEDSLPTPSPSKWASPTWAKVLSLSPDVDTDAHQEIITQAVVYSEGQESLGSTITPLHEAVNAVDSVITIFEDDIHVVATPEDDHDELTPRNFAIPVRPKSLPRRVLTNCMKFIVNGCSRINAWGNLMFRNENHFTSSSVSADCFRETSQLRYKSSTPTLSTYVLLRKEYHQSTNLHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L317</accession>
    <name>A0A835L317_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000114">
        <property type="protein sequence ID" value="KAF9415297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L317"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="143" mass="16628" checksum="A2FD413E05A90149" modified="2021-09-29" version="1">MLMGVSCTLIEKAFLQSMYSGYPCTPYLFTPLLNPTTPQEERYNRSHIRTRNTVERCFGLLKQRFRCLLRGMFGDIETAKKTIVACAVLHNIAIDMREDLFPGEEDNIEPSIQFAPSETIQQYFPSSVRGNIRRRQFIQTHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L337</accession>
    <name>A0A835L337_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_009886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000230">
        <property type="protein sequence ID" value="KAF9411272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L337"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9411272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="20137" checksum="42CC6B97F9CD3BF1" modified="2021-09-29" version="1" fragment="single">LTIFGTSVYGGAVIATSLDYFFERMMMLKWLWERAKLEPAVAPPCRLSWLTLAAWPAAAIVGLTAQCALTATGIYHEQSISAQKRHLKAQQARPVTREQRAEMKQRKYRYLYQVRTAHGDVISQSYVQALQKKAQCGNWSASGGGECSTLQSDSTHLTILAGSEHAPPTDSDDDLNQIRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3B5</accession>
    <name>A0A835L3B5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L37, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3B5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47144" checksum="8458217AA0C472C6" modified="2021-09-29" version="1">MRLSQVLSRQHIDFMFKKHWRVQGKRVPIDTGLEEQLKAKGIQFEDALEFVKGKPVEHERLNIVGPYERPLPLDENHPDYKEQPCFTLRNTNVLLEGISQAQVLTKTIIAENKLPPKIEELAEVPAPSAIHENIKKAILSANVFDCEQKKLSKIKDPERPAYNFPRVLGITDRRRNEILTNKLVQLVEKSSDSEVTLSRYILNDVESKSVFEKEDDLIQFQDISHILVTSNKPVKHDVESNVTFNEIPDLHPIKHTVTLPPEHFYESESKYPIKPTVNVRHPHTTWLHFNKSEVSNIYETPVTEQQILGRSLTHAFTVASAYAKQLHGEDVKDLPEPIYINCIQTDGQKYHFGVLELNTLNVDGTEGTKNVWYCKNNLKLYGSSRYFGGMPVLENYNNKVYGYINALYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3L0</accession>
    <name>A0A835L3L0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000455">
        <property type="protein sequence ID" value="KAF9407588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3L0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="12027" checksum="6310813E38636C43" modified="2021-09-29" version="1">MDDVFKDLEKKGKTDVDNLMKWIKDSKLIDATKEQEVKLKEMFKDVSSIQRVELEKFKEIIEKLALEQKKSVEQLSKQLAAEAPRFLDAAKAGVQAFREALEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L450</accession>
    <name>A0A835L450_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000387">
        <property type="protein sequence ID" value="KAF9408383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L450"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="490" mass="56455" checksum="0ED70E929D3BAD49" modified="2021-09-29" version="1">MSNELLSRASKREREGSTDEEETWTEVKEKKKSRYGSNNTIKEEMNNQVYISSKERLPKQFAMARILKENQFQKASELSVCYGLIKEVDLDLADDEILQNISCPAPAKLISLQRLNRRNRDEGGWCPSETLRLCFDGSHLPATVRVCDINVRVFPYIHQVSQCSKCWKLGHTRKMCASKNVICPKCGGHHENCDTTLFSCVNCTGDHISLSKACPVYKKERKLREIMAEFGCTYRKALEMYVPPEMPLPSENDQLLLTPKYGDTFRRRSTEPTPIQNIYPNLSSQPTYADTVKTKATIHEEKKAVKITSRPQKSEVKPKCQKKSNDEDWTFWNSDGGRKGLEDNMSSEEDDLQKEQCPSLKELWVRIKEVIYLKQLNLSSKIRSILQLCLEWFMLVSLVDNVKYLGLWLDRGLRWKKHVNEVCKRVLKLVNIFKVLVGPGWGVHPKHLRRLYISLIRSRIDFGSFLLGSGGMLLSGCEVHGVIREWPFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4B5</accession>
    <name>A0A835L4B5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 16">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_008600</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 16"/>
    <dbReference type="EMBL" id="JACKWZ010000170">
        <property type="protein sequence ID" value="KAF9413080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4B5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF91">
        <property type="entry name" value="ALKALINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14 16" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032444296" description="Alkaline phosphatase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="857"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="975"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9413080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1047" mass="115628" checksum="36B7588E29614213" modified="2021-09-29" version="1">MRSLLTCLVTVCVAAACVRGDRYHPADPGSRAAATVVNRAETSANYWAQEAQAAIKARLEHKESVKKARNVVMFLGDGMSVPTLAAARTLLGQRRGETGEEAKMNFEKFPTVGLAKTYCVNAQIADSACTATAYLCGVKTTYGAIGVNAEVARRDCDASTDTSRHVASIAEWALADGRDAGVVTTTRITHASPAGVYAKVADRDWEHNQAVLNHGHDTDRCPDIALQLVHKHPGNKLKVIFGGGRRNFLPIDVRDEEGEVGRRTDNRNLIREWLQDKEDRNVTNEYVWNRQQLMSLNDDLPEYILGLFESNHLQYNLQANLTTEPTLTELTEIAIRSLSRNEKGFFLFVEGGRIDHAHHDNLVELALDETLEMDKAVARAAELLSEDDSLIVVTADHAHVMAFNGYSRRGHDILGPSRDLDEEGVPYMTLSYTNGPGFRAHVDGKRPNVTAESDYRGLQWEAHVDVPLEDETHGGDDVAVFARGPHHSMFTGLYEQSQLPHLMASLLTCLVTVCVAAACVRGDRYHPADPGSRAAATVVNRAETSANYWAQEAQAAIKARLEHKESVKKARNVVMFLGDGMSVPTLAAARTLLGQRRGETGEEAKMNFEKFPTVGLAKTYCVNAQVPDSACTATAYLCGVKTNSGVIGLNAEVVRGDCEASTDASRHVKSIAEWALDDGRDVGIVTTTRVTHASPAGVFAKVANRSWEFDHSVVLAGFDPDRCPDIAYQLVHKHPGNKFKVILGGGRRNFVPDNVLDDEERYGRRTDNRHLINEWNKDKEDRGVSHKYVWNREQLMSLKEDLPEYILGLFHRTHMRYHMQSNPTRDPTLAEMTEIAIRSLSRNEKGFFLFVEGGRIDHGHHDNFAELALDETLEMDKAVARAAELLSEDDSLIVVTADHAHVMAFNGYSRRGHDILGPSRDLDEDGVPYMTLSYTNGPGFRAHVDGKRPNVTAESNYRDLEWQAHVDVPLDSETHGGDDVAVFARGPHHSMFTGLYEQSQLPHLMAYAACIGPGRHACSGATHVLGQPVLLLALFILLTSQSQERYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4D4</accession>
    <name>A0A835L4D4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4D4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="101" mass="11087" checksum="9EEFC7BDE0AD6BD8" modified="2021-09-29" version="1" fragment="single">RYIDALKVVLNNAPVGSANQQIKDNALALTLKVLLAIKSTQIEEAVGNLCLDDIDILMKYIYRGFECPTEGSSGHLLLWHEKAFNIGGSGSIVRVLSDRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L679</accession>
    <name>A0A835L679_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L679"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="188" mass="21382" checksum="760249DE960625C9" modified="2021-09-29" version="1">MKDNSLSDNVCQQNLGVAHITGSREEILPILEAFICEIYGYKNISNINAARFQKFCVTYKANTEDEPFKKTLKNCDPSTLPPCKAELQQHLLRTQYITSIWRNAYLRFPSSLTPNRNGWTLHEDTLHFHWFDGDCMPQSVFDAIVHENNKQNNIENDTTDNAGVSELDTDESEVDSDSSDEGASTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6I7</accession>
    <name>A0A835L6I7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_006380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6I7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="590"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="773" mass="87251" checksum="76045F329DB3D271" modified="2021-09-29" version="1">MAFSNETSEGTSVCEMFHAESVTINSGMRLFHENIVAERPQGLFGTISLDPRSSLRHCLDDGQPQLYSLSPLQPHLHLDNDQVPLSSENLLQAASRTTISSSLTHQPSNPSSYCAPDDAVGNDSYRVTILVPCLPKSNKVINDTTPANSTNFKSHPKEVRSTNFASHQKKMSSTNFASHPKEMSPSKFASHPKEMSPSNFASHPKEMSPSNFASHPKEMSPSNFASHPKEMSPSNFAPHLKEMSSSSFSDFASLPKEMSTSKSTFQVICCHGISCLGHAESNIVPIYHSPGIYFEPITNINFYTDHWKTSRECRSSQQESVSRHESSPRELVSLGCQWQWRDTIGVYQNLAKKFLFNRGFRQQRIQLLVNNCELDTVITYKYLGVWLDRTLRWGKHINEIVGKVQKLINVLKILTGSSWGVHQIHLLRSRLDYGCFLYDSSAKSNIYKLVKVQNQALRVVGGFIRSTPIHVMECELCVPPLHLRRRWPAVKYCLKSRSLSDNVTIKLLSDLSAFRHNRYWSNKKLPLLVSVFEEIKEEIDDDDVSLDTWVSNINTQNIIKIKLDSINKPKKTYDYNLIKTETLKELREKYDEYYIIYTDGSNSAKGNGAAYYDPLKSENNSDSCFKITNAVSVMSLELFAISEALVYIQNYDKRKAVICVDSKSALQHIARCASGCRGASIAYGILSKIHNLTSNGFDLRLQWVPSHIGLHGNEEADRLAKLAIDERKETLFVKKMYSAAGYLKSSHHEPAKKSNTKLHKLLGSARKEHIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6Z5</accession>
    <name>A0A835L6Z5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Shal K[+] channel interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6Z5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="586"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="668"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="784"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="860"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="98173" checksum="8EB98D3498F4B6EE" modified="2021-09-29" version="1">MNPFLCSKRLVVDGDRGYLEGLASRYADLFSTHYGDVLDHLEELRRHEWDEMSPRMRVLGGPGTPQTPPSASPGSLALNNLTTSHSQPIYVPGKYSPSSCLTEKEEDEIYGFGYGVFGKQMLQRQQQQKQLLLAQPTQPLMHNTQHNYQSCLSPRSAYFYEFPPSAGIVVVDNCLGTAKKKVTTFSRLLRGLKSHRKEKHGSCSPKHAHSPRQVLPPQRVDTPDSVLQSGLGLGPGPDTALRSMVDPRDYDRLRFFQMSAAQPNTFEETIHRLKVQEAMKKKDKLAREQEEILRDIRHGLMNMGRDGVRGPFGDDTYMYDDEARGLSGRGHWYDEPPYESDPEDFLMGGGAPAASFQNGRVCFTLNLRNEPRGEGVISLRSAGDISLARTPRRGLIIPQSGPYPTTVIPLRTARDRESGDYAASDIQSIGSRLSGISLESNRSERDSRRGYRQMSGYRIGADPLSPASSDYEDQESETDSQHIATVHKSAEECEGVSNLAGKVRGLRQDVQRKISRLRQERGPEGSDRRTSGDQAFPCSNSSFESLPSGSGSSTQALVRAGSNHSSLSAEENIELSPAGRSLLVPQMLCRARALVDYVPNIYEKDALRYKKGDIIEVINMNASGIWRGVLNNKVGNFKFAHVEVLSERDTVRSRSSKWCKSRERLWETRPRTVEELLRRIDLLEYAVAFARNGYEDIELFKEIEPSDLDYLGIMTPEHRTRILAAVQLLHQLECGEGEAEADGGGSSSEGGDSPFGRRQFPRDSGCYEASVGVGGVRVRTSPLVHRADEPSHRPPEPAPQAKRSIRRRQPDDAECDRIERYPGTGTERTTVRSGGLPGGARDDTCESDHRLNVVKFVAGGEPCASEKSSDSGVSSSSLSSAHPHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7R6</accession>
    <name>A0A835L7R6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7R6"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06885">
        <property type="entry name" value="PX_SNX17_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000001">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000145">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000008">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048763">
        <property type="entry name" value="SNX17-31_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048767">
        <property type="entry name" value="SNX17-31_FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21273">
        <property type="entry name" value="SNX17-27-31_F1_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21271">
        <property type="entry name" value="SNX17-31_F2_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="54821" checksum="6F7C8E0A0529CC69" modified="2021-09-29" version="1">MHFSIPDLQQFHDDNGISYTGYNIHIDGVFHCTARYKQLLSLHEQLQAQNPYVKLPQFPPKKLFLTNSQLEERRVLLEKYMQLVGQNPLFTSSDLLVTFLFSAQQETHGVKMHEVEIEISLMNGYRIPLSVSSTDSSNTILDIVCTQLNLPKELVKYFSLYLFNWSCAKDGQPALKKLEEYESPYISQKYVRPEDKIVLRKSYWDTCYDVDLMIDRVSLDLLYLQIIEDLDLGWITADPQTRDMLSSYKSKKQKREYVELAKTLRHYGRIPAGEAVTELSNVTDGAPEGTCRVRVSLASKELTLLSLTPPAREQRYKVTRMRCWRITTLHTIERSPAQNGHGALLEDSNRNFELSFEYLISKDNLKWITLRTEHATFISVCLQSIVDELMRQKAGEGPASPRCSKRGSLTYLRRDGSSQVITPSSSSDTLSSTNGDSGTSGSSREIFSVQKLTEKFATVSFKPGRECVENNAFEAIGDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7X7</accession>
    <name>A0A835L7X7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7X7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="229" mass="25546" checksum="4D23C7BB9123D7BF" modified="2021-09-29" version="1">MKSVHKVIKLSMSLSPEILLSSAARERCISNIAELPSFNVRGGNPKHTASVLVPVCVDNSEVCLLYTLRSSNLSSHSGQVSFPGGKIDKDETVYDAALREAEEEIGVLAKDINIWTKMNQVQGRDGNMLITPVVGEIMNFDMKKLTPNEGEVADIFTIPMNVFCDTNNHGCYKYNNYAIPVYNGGKHTVWGITGIITHMFLNSFLPKELYCPDFLRKEYKLQELMPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L888</accession>
    <name>A0A835L888_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L888"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032940689" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="90" mass="9927" checksum="11649F37FE3EE7A0" modified="2021-09-29" version="1">MKTAPVFLVVLLAIICAVHCKDLIVGSSFNNRLIHQEKAEYNAIPLKKRVKEVFFSDPGQQIIKGIILRDLDHTEAIPSVTAGGVGFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Q9</accession>
    <name>A0A835L8Q9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Q9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="20224" checksum="56F7A7978DA4FBD6" modified="2021-09-29" version="1">MFNYDTQRYQFVVRSCYLLGTIKMTGKIIALFCLQFALFNTISAQCLNRIVPGCGQNILPMPVPVSDTLLQNQVIIGQNYPPIVDLPYGVEAIVPNQVYNPATTIIQDSSVANNLANALQLLVVSNLLSNTLPSSSPDVIIPGMGLGAVDYGMLGPYNPMVAPMNPMLAPINSTWGRIGGEKLFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8U2</accession>
    <name>A0A835L8U2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8U2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="929"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="962" mass="113051" checksum="426305E6203BB38C" modified="2021-09-29" version="1">MFVARQNAKMMIEYTTAYPFKLPESSMVCVYCCDSFQDPAKFRDHMTIEHQDFNVRMAFAHIAEGSVKVDCTDLKCRICLETLANLELAADHLLNVHNKNVNPKHDLGLHPFNIYYGKYACAICSEKFSTLALLSKHTHSHFVQYTCDACGKSYASLTSLQCHLRYNCGSGASKNRCRKCRKMFTSVSERTKHLEKSVRCRQHVCNVCGDRFLTWNMKQTHLKESHNVPEKSYNCPECHIVFTKRDKLRMHFKTTHTNDYVECSYCEKKFDNDRNLKKHIVVHTGERNFICPVCSKAFPRKSTLGQHMWIHSAVKKHECKMCDKTFNQRVSWRTHMKSRHPELCPFDLQNDKLSCAVCNAKASNIRSLSRHIQKHFFQCTCELCGKSFATSTSLQKHLEFSCPHVAKQRKCRKCKVVLYSTEDQKRHYENSRQCRQHLCSVCGDRFSTWKIKQNHMEQAHGIPKKVYHCPECGVVFKKPNVFRAHFKIAHTDEHFECPSCDRKFDTKYVLDRHMVVHSNERLFSCDICSKTFPRKSTLRQHMWIHSAVKRFECKMCDKQFNQKVSWKTHMKSYHPDLGVKPEPINVLLSPFYFRALININKGVLSVLDETSVMSTARRNAETILSNATVYPFRLPETSLVCVYCYKTYEDASLFRQHMKDEHQPFNVQNAFAHCATYETYLKIDTTELSCRNCSEKFDRIDVIAHHFNDKHDAKINFDFQLGVHPFKFSQDKLMCGNCDLNFPCMRQLSRHISSHYQNYNCDSCGKSYTTSNSLKQHQRFSHIPDERICRKCKKTFSTLQEKKYHTVNSPKCWIYQCRICGERFLTWKNKEEHLVEAHGESKKSYSCPECSMSFPTRSIYRTHFNTTHAEVKFPCTYCGRKFSAKRYLDQHILVHTGDKAFQCNVCSKSFPRKKNLSQHMWIHNESKRFECKPCQRQFNQRFSYKSHMKAHHPDIPEDDWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8U8</accession>
    <name>A0A835L8U8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_001539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15210">
        <property type="entry name" value="7tmA_GPR84-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="155"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="573"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9422996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="931" mass="104589" checksum="B358B9505987097B" modified="2021-09-29" version="1" fragment="single">NDCEALGLFLGKSDHISVSLKLHWARWVGPDKLKACRGRISEWICRKIQRTVAARYQRFLTSCDPITSHIDKMPYHRTITNLLTGKMGDLLPSIPRSTFASEVDGGNYSLEGQGVTEYASDAELAAVELFRDYPEPLLRFASVCCVLFMLVGIPGNLITIVALARCKKVRNATAVFIMNLSCSDLLFCCFNLPLAASTFWRRSWAHGRILCRMFPLARYALVAVSLFTVLAITINRYVMISHPRLYPKLYRRQYLAVMVASTWAFSFGALIATWLEKWGRFGLDPTIGSCSILPDKNNRSPKEFLFVGAFMLPCLAIVICYARIFCIVREAARKSRAPARGRSRPGLEDSAVGSASTALERSPGPENGINHVAPPRRALLAPPALHCPPTPGPERSSSSGVDTLDGHDEECALDAKPRTPSGGETAKRLRQAAVALRRSPASVRPPRLTPKDRKLLKMIMAIMLSFWVCYLPITLTKIFREFTSHPAANIAGYILIYLTTCINPIIYVVMSSEYRQAYKNLLMCRRWAGIPGLHSYESDAALAAVELFEGYDQPLLRFAYISCILFMLIGIPGNLITIIALARCKKVRNATAFFIINLSCSDLLFSCFILPLAASTFYNRSWAHGKVLCYMFPFARYALVAVSLFTVLAITINRYVMISHPRLYPKLYTTRNICFITAGIWIFSFSALLPTCFEIWGEFSLDPITGSCTIVPDDNHHSPKKFLFIIAFILPSLAIILCYARILWIVRKTAKKSRNPPTQMKAMSISTTTIATRSIDLDKRLPRYTVPTFPMNCFIHTAAEISSDSSTPSDTERQSVSPQDNTPRFGHDNKNFRRSFIATMRWTTIPPKPRLPTKKDKKLLTMIVAIMVSFCVCHLPITLMKTIFFETTTHSVANVFGYVLIYFTTCANPVIYVVMSNEYRQAYKSVFKCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L928</accession>
    <name>A0A835L928_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_007321</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. The complex interacts with the TIMM23 component of the TIM23 complex. Interacts with SLC25A4/ANT1 and SLC25A5/ANT2; leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L928"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000001">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033779">
        <property type="entry name" value="Tim44_TimA_adap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="17">
        <location>
            <begin position="279"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9414930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="435" mass="49496" checksum="4A48B0FA82F6084A" modified="2021-09-29" version="1" fragment="single">HSCRQLLYSPARWKSAIPINLKQTVNFNKTDQYTVQECRHYSARKGFFSSIIENIKDEMAKNKEMKDNIKKFREEAQKLENSEALLAARRKFHAVESEASKSSEVLKETLEGIKGKMEHVIEEASKTDIAKKAGQIKDDLSKTAKGAAESIADTGSKLGQTSAFRTISQATAVVKDEISPRGLEGRVYMAPSALRKRVEVASDERTFAPDTETVGVELHKDSKFYQQWENFKNNNQYFNKVLDWKIKYEESDNPVVKASRFVTEKVGSLFGNIFEKTELSKTLTEICKIDPNFTAQKFLEDCANDIIPNILEAMVRGDLEILKDWCYEGVFNILATPIKQCKQLGYYLDSKILDIEQIELVMGKMMDQGPVLVITFQSQQIMCVRDSKNKVIEGDPDKVMRVNYVWVLCRDPSELNPKAAWRLLELSASSVEQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L946</accession>
    <name>A0A835L946_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L946"/>
    <dbReference type="OrthoDB" id="7440370at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032381653" description="Cuticular protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30458" checksum="1FC66BF886BB3FD3" modified="2021-09-29" version="1">MSSAVKFVLVLSLWAVIQCSPYDDGKYHPKKYRVYDDGGYYRPLDEGKYVPGDEGKYTYIYQQGLYPEDDGDYRYVHQVGPNGGFGGNGGYGGNGGNGGNGGYGGNGGYGGNGGFGPNGPNGPNGPYGPKGPPGPPGPPGPPGPPGSGGRRGNPIDYIGSKTYAHRYPYIHKVIKGLVDKYVSDEAVNFGDEYEGSTNHYRKVYADKEIAVKCRYLEPTYNQTEFVTQYPPTLKLPHGEKFGSYYSFRGTKVLNTVKNSLTNKVKLEYEVFVRVVDTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9B3</accession>
    <name>A0A835L9B3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_003394</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the hemolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9B3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000052">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001928">
        <property type="entry name" value="neuroglian isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001718">
        <property type="entry name" value="Neuroglian, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001687">
        <property type="entry name" value="Neuroglian, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="123"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="216"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="316"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="409"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="498"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="591"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="693"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="795"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="892"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9420333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1163" mass="130301" checksum="E591475D6516D043" modified="2021-09-29" version="1">MDMTSPPKIVKQPTQEEILFQVAQPGEVDKPFIIECEAEGEPAPKYRWIKNGKPFEYTSYDNRISQQSGRGTLVVSQPRDEDLGQYQCFAYNEWGTAASNSVFVRRAELNSFKETDSQQVVRAEEGKPFKLTCEPPDGHPKPKVYWMLQGDQGQLKTINNSRMTLDPEGNLWFSNVTRYDASVDFAYICTANSIFRNEYKFGNKIYLEVTQTGIAPTLNRHEPVRQYTTRKVEKALKGKKVELYCIYGGTPLPQIVWKKNGRSIVSSQGITQDNYGKTLVIRYPTYEDQGTYTCEVSNGVGTAQSYSILLNIEAAPFFTVEPEFQNLAEGETAEIKCEASGTPEPKITWIHNGKPIEQAEPNSRRQVNSNSIIITNLVKKDTGNYGCNATSSIGYVYKDVYINVQSIPPEIKEGPENLTRVDGSEAVLKCRVFGAPKPIVKWMKDDVDVTGGKYNITADGDLVIRDVSYTDVGTYQCYAKNKFGEKSAYGSLDVKKRTVITDKPEHYEVAAGSSATFRCNANADDSLKLQIIWLNDGQQIDFENQPRFRMTNDYSLLISDTTELDSGEYTCIAKTAIDEARAQATLTVQDKPNPPALDGIECHEKTATLRWHSMGDNRAPILRYSIQYNTTFTPDTWDVASDNVPAIDTSWTVQLSPWANYTFRVSAWNKIGPSTPSSHSDVCTTQPDVPYKNPDNVVGEGSDPTNMVISWSKMPQIEHNGPGFYYLVTWRRNITGQPWVEEQVRDWQQTQYTVLNTPTFVPYKVKVTAVNYKGTSNVTPVEVIGWSGEDIPMHAPQNFTLVQVTTGTTALLNWNPVSPESVRGHFKGYKIQTWVDGEEDRLKEILVKADASSALVSKFKPYKKNNARILVYNGRFNGPPSDTLSFHTPEGKPGTVKSFEVYPIGSSAMLLKWDKPVDENGVLTGYKIYYQKVTGTSLGPIQERKKEIDPKFDRAKLAGLEPNTKYRIEIRAKTKAGEGDKYYVEQTTKSVVTAKPDIPVFETSTLPAKEGTAHILVRWIPSLDGHAGTHFVAWYKLKGHPDWSKTNEVTDDDYVILTGLEPGQVYEVKLTAHDGEYFSSSEIKDVDTTIDGPIVEPGEDKTASAGLDNKSRHSMSSGTKPGPESDTDSMAEYGEGETGMYLHNLTRSYTYKLQIKPQRAKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAX7</accession>
    <name>A0A835LAX7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAX7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="36730" checksum="479D1AFD23BEACEF" modified="2021-09-29" version="1">MSDREKISFRCFQRSRSRTRNGSREPAPKPAAMSRGHSRSRSRTPPPPKASSRKYRSPPRRVSQRVVEKCKDNWAKLRNAYCSALKRRKTKSGQAATQGTPWKYEDQMGFLRPYMEMRNTKTNLIPPSSPSTSVETITSELPAESPEVPESPPDFRSESQQSNLSSYSQRSSSSKKKPDLADIYDMMKTQHSLRQQKQQSKLDLDETDMFFLSMSKAVKALPKLDQTKIKLDLHMAISQAEIRNIEMERVVKTPLRIVSQTVVPPSNQPLPEPSRVYYYHNSPTEINEFSPESQSILDPEAQNTNSTGEENLSTYYSGVTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBW0</accession>
    <name>A0A835LBW0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBW0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000133">
        <property type="entry name" value="Serine-threonine kinase receptor-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="321" mass="35532" checksum="43E80B4F761FA9A6" modified="2021-09-29" version="1">MTTFKQVPLTCGGHTRPVVHLDFSDVTKDGYYLISACKDGKPMLRQGETGDWIGTFEGHKGAVWGVALTQNANLAASGAADFSAKIWDARYGEVVHTFDHEHIVKSVNFNADDTQLLTASNEKLIRVFDLNKPEAGALEKISAHTSSIRHAVFLHNSRIVSVSDDLTMRVWDRTSGQEVHKIEFPTIPNSLELSRDGAILTVAHGTNVSFYSSDTMRKMREFPVPTKCYSASLAPSRATFVCGGEDLKVYKFDYNTGTELESNKGHFGPVHCVRWSPDGELYATGSEDGTVRLWQAVPGRVYGLWRRTNEHTPVLNGVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LET7</accession>
    <name>A0A835LET7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_001922</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LET7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000016">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="127"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="450"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9422332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="698" mass="76209" checksum="B891385F96E7F403" modified="2021-09-29" version="1">MWQLVQTGSCQLIRQRLLTAKSNVYFTNLMKNRPSNVVKRYFSEVKTSSDKNAKPGLLLLCSPWKLCTGVSLALGARYFLSNGPAYCKAHIGPSRIIQRRPNVEEDTAKFDWDKFLSYLQPHKWLLIAAIGSALVVAFFNVYIPAMLGEVVNVLASQRQNPSADFLDAIRLPALKLVGLYIGQALFTFMYIHLLSQVGERVAAQMKQDLFESILQQDIAFFDQERTGELMNRLTVDVQDFKSSFKQTISGGLRATTQVVGSSVSLLVISPQLTGLTLLCVPSVVIGGTFIGSLLRKLSREAQTQIEKSTLVAEEAISNMRTVRAFAGEENKAQMFAQECKAAAELSMELGLGIGLFQAGTNLFLNGMVLGTMFMGGHLMASGQMSAGDVMAFLVNAQTVQRSVAQLSLLFGSVVKGISAGGRVFEYINKKPVMDSSGTKVIRYHEFHGDIEFKDVTFAYPSRPEATVLKNFNLKIPAGKTVAIVGTSGNGKSTIAALLERFYDVNAGQVTIDGIDVKDMDCKWLRGRALGIISQEPVLFATSVKENIRYGRPEASDDEVYRAAQTANAHEFIVGFPDGYDTLVGERGMSLSGGQKQRIAIARAVLKNPPVLILDEATSALDSASEKVVQTALETAAKGRTVLVIAHRLSTVMNADLIVVLNKGNIVEMGTHSQLKKLKGFYWNLIKQQDQSAEASVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1S5</accession>
    <name>A0A835G1S5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000614">
        <property type="protein sequence ID" value="KAF9406270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1S5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="248" mass="27360" checksum="9C79EAC50D9C1A24" modified="2021-09-29" version="1" fragment="single">NFKVENLEKDDNLPNLPICWSPPHNNNDNISNITIRKKQKLPTLPPETTSKLNKDSSANNNASMMDSHVLSDHEILSDTYISPNKLSKTLDGTLSDVISMAEMKDTLSQCKKKLNMTELELDNLILENNSLHKQIEKLTTENNTLKSLCHSSSIIESTPNPKTEENINAAKCSIYSSTIPAGLRTSTDIKPGTKSSKIIAETKPNAVTDEIVKSCKHLQLKPGDKLVLSVGENDDNAKKVLSQLNDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G226</accession>
    <name>A0A835G226_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_014080</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000845">
        <property type="protein sequence ID" value="KAF9404965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G226"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.380:FF:000001">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000014">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000032">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000098">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="607"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="19">
        <location>
            <begin position="813"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9404965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="881" mass="101468" checksum="8A9D5AEC9F63D4E1" modified="2021-09-29" version="1">MTEEKNLPTKYQPDEVEKGRYQKWLDQDLFKPSGDQKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMIIRQKRMQGFDTLWLPGMDHAGIATQAKVEEKLAEQGISRYDLGREKFVEQVWDWKEEYASHIREQWAKMGLSLDYSRERFTLDEGLSEAVRKIFVALYEKELIYRGEYIINWDPKAKTALSDIEVIHKDIEGAFYHMSYPLSDGTGVVEIATTRPETMLGDTAIAVHPEDERYQSLIGKTVTLPLVDKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMHKDGSMNELAGKYAGMDRFAARKMIVSDLKEIGRLIKIETMNHSVGHSERTGVVVEPRLSTQWFVKMAPLAEQAMKNQGTDDAVEFFPPRFDQTFMRWMENVHDWVISRQLWWGHQIPAWYHKETGEMYVGMEAPADAENWTQDSDVLDTWFSSALWPFSTMGWPDEAAADYQRYFPTSTLVTGYDIIFFWVSRMMFQSLEFTGKAPFKNVLMHGLIRAEDGRKMSKSLGNGIDPMEVIDKYGADALRWFMSNGSTPGQDMRFSYEKMDASWNFINKIWNASRFVIMNVEGMTFADIDFSGEKTVADRWILTRLNETIERVTDLFDRFEFGEAGRQLYNFIWDDFCDWYIEMSKEILYGENETAKQTTRSILVYTLDQILRLLHPIMPFVTEEIWESIPHQGESLVVADYPVVHAEFSDETAARGMEVLKEVIRAVRNIRAEVNTPLSKPITLLIKTSDTAIDTFLIENTNYIERFCNPEELTISSDINPPELAMSAVLTGAELYLPLAGLINVEEEIARLEKELDKWNQEVKRVQGKLSNERFVSNAPADVVESEKAKEKDYLEKQVIVKERIAQLRTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2Y8</accession>
    <name>A0A835G2Y8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_014302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000956">
        <property type="protein sequence ID" value="KAF9404513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2Y8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18541">
        <property type="entry name" value="ABC_6TM_TmrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000221">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="236"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9404513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="53611" checksum="4FFF7CD420EB16C8" modified="2021-09-29" version="1">MDNVFYQKYRTGDLMAHATNDLNAIQNVAGAGILTFADSLITGGATIIAMILIVDWRLTLIALIPLPLLAVTSRVLGSKLHDAFRDSQAAFSTINDKTQESITGMKVIKTFGQEKEDIQDFTEKIDDAIVKNKRVNFLDALFDPFITLIIGISYVLTIIIGGKFIMESTITIGQLVSFISYIGMLVWPMFAIGRLFNVLERGNASYDRVNELLHEKTHVVERKDAIQEPAKGKLSVEIAEFTYPKDEQATVEQIKFAIDEGDTLGIVGKTGSGKTTILKLVLREYDRYQGHISFGGHNIKDYSLDALMKSIGYVPQDHFLFSMTIRDNIRFANPDFTDEEVEKAAEMAFINNDIKAFPNGYQTMVGERGVSLSGGQKQRISIARALIVNPELLILDDALSAVDAKTEEAILSNLKTARKEKTTIISAHRLSSVMHAKEIIVLDEGKIVERGTHQELLRLAGWYKRMWDKQQLEAKIEGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3S8</accession>
    <name>A0A835G3S8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_014296</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000952">
        <property type="protein sequence ID" value="KAF9404530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3S8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03216">
        <property type="entry name" value="ABC_Carb_Monos_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03215">
        <property type="entry name" value="ABC_Carb_Monos_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06580">
        <property type="entry name" value="TM_PBP1_transp_TpRbsC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001390">
        <property type="entry name" value="ABC transporter, ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000127">
        <property type="entry name" value="Ribose import ATP-binding protein RbsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050107">
        <property type="entry name" value="ABC_carbohydrate_import_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790">
        <property type="entry name" value="CARBOHYDRATE TRANSPORT ATP-BINDING PROTEIN MG119-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF4">
        <property type="entry name" value="GUANOSINE IMPORT ATP-BINDING PROTEIN NUPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="251"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9404530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="852" mass="91556" checksum="48C2FCEFC2A54C56" modified="2021-09-29" version="1">MRDITKQFGTFKANDNINLTVRPGEIHALLGENGAGKSTLMNILSGLLEPTSGEIFMNGSKVIINGPTAANRLGIGMVHQHFMLVDAFTVTENIILGSEPTNGGILDRKKAKAEIKRVSEQYGLSVDPDAYIRDISVGAQQRVEILKTLYRGADVLIFDEPTAVLTPQEIDELIEIMRGLVKEGKSIILITHKLDEIKKVADRCTVIRRGQSIDTVNVKDVSSQQLADMMVGRSVSFKTEKKAAEPKEVVLSIKDLVVKESRGLEAVKSLSLDVRAGEVMGIAGIDGNGQTELIQALTGLRKSESGSVELNGESITNKHPRAITESGVGHVPEDRHKYGLILEMTLAENIALQTYYQKPLSNNGVLNYTQINSYARKLIEEYDVRTTNELVPAKALSGGNQQKAIIAREIDRDPDLLIVSQPTRGLDVGAIEYIHKRLIEQRDKNKAVLLVSFELDEILNVSDRIAVIHAGKIVGIVDPKETSENELGLLMAGYSLEEARVELNNKAGQDPIAGYQAMLQTAFKSPKSIGEIFVTAAPLIFTALGFAVANSAGFFNIGLSGQALCGWVASIWVALSMPDASRMIVLPVAIITGALAGAVAAAIPGLLRAFFGTSEVIVTIMLNYVFLYTSTHIVNNVMSGDLMSNKGVTKVIGENASLRTAFLKEISGGSRLNLGIFLALIFLVLIWFLMKKTTLGYEIRSVGLNPYGSEYAGMSSKRTIVMSMVISGTLAGLGGVVLGLGTFGNFFVQGSSLSIGFDGMAISLLGAGSSVGIFLSALLFSILKLGGQGMPLRAGVPIELVDVVIASIIFFVAISYLIRFLLAKASGNKKEVVVVEELDGQTDLNSQEGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G499</accession>
    <name>A0A835G499_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000817">
        <property type="protein sequence ID" value="KAF9405079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G499"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="355" mass="40427" checksum="99F62CA9A23C467F" modified="2021-09-29" version="1">MAEQSSMSSSTPFTWGCCDQVVVNEKYATCVKCHKKYHYNCLSLKEKYNVPNDWQCPTCINSGPKISKSDSTPLRNVSTTRGNKRPALGSPPKTDNITLSCDDIRQLIQDAVKKEQAEMLSKFTETLNRQLQPIKEQMDKMDKSMLFMNSQYEDLLKEYCASKETVKELQKENLEMKMCINDLSSRVNQLEQQTRSIFQNIEIQCLPEKKQENLLQIVTQLSKVVGSGIVDSDIKYCTRVAKQSSTNSRPRSIVVQLASPRTRDQFLAATIKYNKSNPDNKLNTSHLGYAGPKSPIFITEHLSTTNKALHTAARIKAKELGYQFVWVRGGRIFIRKEQESEHILVRSKDTLNKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4U8</accession>
    <name>A0A835G4U8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_012503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000465">
        <property type="protein sequence ID" value="KAF9407493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="93"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9407493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="440" mass="49456" checksum="A0E2A9E4DD17E3DD" modified="2021-09-29" version="1">MTNSWGLPNNNNEISFVQCFVIIVYKLEPDVHSEDEFYLLVNGSLFVPYSRPYLLGTRDYCMETFWNESVPAGVTLPVVCFETPMEDTKTSSTLIAYATGLLISVPFLLATASVYLFITELRDTHGKALACHTVCLALAFTCLAATQLAGHAFPAAACTIMAYLIQFSFVSCFFWLNVMCFDIFLNVRRYINASVTRRSMRRRFAWYCVYAVLFPILLLIVTITMDLSPAVPSTYLKPNFGVKGCWFKTDQAALPYFYGPVALILFSNLCIFFFTSRAIATHYDKLKDVTPLDLTHSDFSTSDDWVRLRSVLGQPIQETTSSPPQEAPTNFNQRLKKYKKLFRMCCLLSFIMGLSWVLEVVSWAAGAGSDVMSVWSVFDLVNALQGVVIFAIFVLQQPVRSLVKSSHLFSTCKRKKDGSEVSVVSERNSIIAGAGRRDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G564</accession>
    <name>A0A835G564_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000595">
        <property type="protein sequence ID" value="KAF9406425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G564"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033024238" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14088" checksum="BCEED667DC0FFAD7" modified="2021-09-29" version="1">MLVHLCAPLVPLCGSASGCSVHPTSAATAATNTSTDPTILSSRTRVSLFDRNHKMKQISKFEKSSCHELARGACAAVQVYLQLLCCRYYRKSVNTSPDTIHQSWPTQAGPHAAAAYSTLPISCNAPGSQHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5P3</accession>
    <name>A0A835G5P3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000538">
        <property type="protein sequence ID" value="KAF9406868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5P3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="35082" checksum="594EDD3E5CC5F637" modified="2021-09-29" version="1">MKSESSYTSSEEGCGGGERHAVLSYEQVRRLNDVMDEVVAIHGRGNFPTLHVRLRELVAGVRARLEAPQTAGGAGVNVRDVRLNGGAASHVLADRPQPYSDIDLIFTAELPTARHCDRVKAAVLGHLSTLMPPATPRRRASPAGLKEAYVSKMVRVNSDGDRWSLISLGNSRGHKSVELKFVDTMRRQFEFSVDSFQIALDSLLAFHECAQLPIGENFYPTVVGESVYGDFNEALNHLAEKLIATRQPEEIRGGGLLKYCALLAKGYRPARPDKIKTLERYMCSRFFIDFPELGQQRAKLEAYLRNHFVWERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G648</accession>
    <name>A0A835G648_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_012313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000436">
        <property type="protein sequence ID" value="KAF9407779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G648"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9407779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="23342" checksum="BC3C6FB4F687A955" modified="2021-09-29" version="1">MRKHIIPVLNPDGYEYSLYKDRLWKKNRRQVSDFCYGVDLNRNFDYNWGKQDSTRSECSNTFCGPAPFSEAETQAFKKLIDGPHFYGYLSIHSAGTKVLFPMGVTRSDHPEQIMMTKAMAQAMRSFDNMQFLSGDIHALRKVGYGMAMDWMYFVKKITHSYILETRGEHGFDILGVKEILPAAKEIRMGIMKFSELILILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Y8</accession>
    <name>A0A835G6Y8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000345">
        <property type="protein sequence ID" value="KAF9409028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Y8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="499" mass="56618" checksum="24C871CB17F5D71A" modified="2021-09-29" version="1" fragment="single">TNNSIIKKESLDGSYNVYHSDKDLIFQNDRNVLSSLPTPKSIIPKTHEFLNRIKSNPAMKNFGKKEPDEVLVKRHIKGNDLHTSSFFKRTKTTLSSTLQKKRKLPAVEFGSDSDDLNEYLNYFDEIEKKPLPVFHEIENARKSKNDPRNLENVYLYQQNNHSEHSKDNVFDLKSLPSKHCQSCEQCVCPNTKNTGKAPGIGNVHDCTRKPEYTSTTNFYPPYNIHNTPTNNPPGPQSTKVRQVTSGYNFPMGIGYPMGIPFGMPAGYAGGIPIGVPANVPIGYAQGVPQSYYQDNNFKEATTYNKPCRNPNHLLYYNDDDDTGKIYVDKDDDYKKRKRKHKGEVFVNIEYDVEETKKPIQKPFNRNNPDILENDIFKDAKKSCDDTIIKKCFCCSSSSLDVNNLNFESIFILSISVIVRGCVAVVFHLLSLEPETYIIIICGFGNAHETKMQQTGFGNPNCRASAFGRECIATIEPQSNRMLTSCARPIRVEWDWSPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G738</accession>
    <name>A0A835G738_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000489">
        <property type="protein sequence ID" value="KAF9407270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G738"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27665" checksum="93CFC70C98022C78" modified="2021-09-29" version="1">MSKCNKVKNPCKICLGPVTNKNGLQCHGACQSWAHYNCLNYTPGKIKDIKAGIIKVTCPCPDCRTSMPKEYRTDTPYSCNNSQCPANRPPKCDNTQCPINSDQKCGRPKAPSCALGTCGTDCKQYSSSHQMDGCPPPPLPPPCNRYGTVSPITSSDACLTDRCPSGCSSQNDVHGDAGMFQMSGSTPSFHVVEQMCNTVGQLTNQINELMMQMKEAVNCNRGGCCPPPPKATCQQKGPKSLCPKPCFCPGNPARRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7L5</accession>
    <name>A0A835G7L5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_011958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7L5"/>
    <dbReference type="OrthoDB" id="6343684at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF237">
        <property type="entry name" value="CUTICULAR PROTEIN 65AU, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032685209" description="Cuticular protein RR-1" evidence="4">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9408321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14344" checksum="3BBB830D78B4EB7E" modified="2021-09-29" version="1">MKFLILSVCVALAAADVSHVVANNDKSAQILRQELNVGVEGQYQWAYDTENGISASEDGSLKQIDAETKAQVAQGQASWKSPEGEVISFQYVADENGYQPQGSHLPVAPPIPEAILRALEYIRAHPPPEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7X0</accession>
    <name>A0A835G7X0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_011768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Nup35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000373">
        <property type="protein sequence ID" value="KAF9408600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7X0"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12441">
        <property type="entry name" value="RRM_Nup53_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9 10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9408600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="299" mass="32602" checksum="396EF36ADF1B5E84" modified="2021-09-29" version="1">MEPMTLGSPTHSPSNSPNVAYLPPFLLGEINPPTTPRTNSLSPTKGRSLAFGSPTSPSQTSTPDQKAYRQNMSMHQQALYNHQNMYPNVPTTPNIYPSMPTTPNLSYTSKPNGPPIEDLFDTIKSNEPSMNKSLFQDSLYGNNNSMAQNGYGNMNNSVNNQSLATPWQDGCQEHDEYWVTVFGFPPNAANTVLARFSNCGAILDKQYPTQGNWAHVRYATRAEKERAMSLSGRQVLPGVMVGVVECKEPPRIGVASPGITSPERQTGVRSLCPTPIANAPVPQRSSGLISKALDYVLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8P8</accession>
    <name>A0A835G8P8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8P8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="70" mass="8214" checksum="E0F94035C3B50274" modified="2021-09-29" version="1">MPREIKDIKDFLLTARRKDAKSVKIKKNPENVKFKVRCSRFLYTLVITDKEKAEKLKQSLPPGLQVKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G946</accession>
    <name>A0A835G946_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000251">
        <property type="protein sequence ID" value="KAF9410704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G946"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF61">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="32"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="379"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="529" mass="60241" checksum="37B538CD8A400DF8" modified="2021-09-29" version="1">MRIMASETISSAELECLPDRIADTFSGMKVLITGGTGFMGKVLVEKLLRKCPDIEQIYLFVRAKKGKNPKQRLEEIFSGPLFEKLRDMRGGVEPLLAKMTIVNGDVSEPDLGMSPEDRQMIINQVDIIIHAAATIRFDEELKKAVLLNVRGTKLMVELGKACKNLKVFIHISTAYCHLHEKLLEEKPYPPPADPHQIIQAVEWMDEETIANMTPKLLNKLPNSYAFTKALAEALVVEAMEKANLPAMVLRPSIVIPIWQEPVPGWTDNINGPTGLLIGAGKGVIRSMYCKSNSYADYLPVDVFINGIMIVAWNYLKNGDKKCNIINFTSSAEIKVTWSEMIDAGREIIMNRVPLNGVVWYPGGSMKHSRMYHNICVFFFHWIPAFIIDTLLFCLGYKPVLCRVQRRITKGFEVFEYYTNNQWDFKSDIAQTLRQKLNAKERRDYKVDAVGLDISKYFEDCIRAARIFILKEYDDTLPAARRHMRIMYWVDVIVNCLFWGFLLYWLSGWMTTSKAIVPDTATPTVIAMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G954</accession>
    <name>A0A835G954_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000355">
        <property type="protein sequence ID" value="KAF9408890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G954"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF108">
        <property type="entry name" value="OBSTRACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032804146" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="227" mass="25785" checksum="062465565B88F53B" modified="2021-09-29" version="1" fragment="single">LSFFAVLLAVTFASCAQVEDPCKTKSRVVADDKYCDKYWECDNGQSIQYDCPNGLVFAGKHRGVTEGCDYPWRSNYCEYPKVQINPPIGSEHCDWLYGIFGHETSCTRYWTCWNGTATEQLCIGGLLYNENAHSCDWPENVDGCQKHPLCNEDPNGNVPLGKSCNRYWQCQGGYPRLQRCPAMLVFDRRSLRCVVPPTEECDVPTTTAPPPEEENQQDLRQAQDLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9U1</accession>
    <name>A0A835G9U1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000238">
        <property type="protein sequence ID" value="KAF9411019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9U1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000302">
        <property type="entry name" value="Ankyrin repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="9">
        <location>
            <begin position="158"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9411019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="35689" checksum="0C5C62DC8E3E0FDC" modified="2021-09-29" version="1">MSISTCSEEEDVYPLHECIFIGDVRKLSSLLRNHDVARKDKHGNTALHLAVMLGRKECVQLLLAHGAPVKVKNLAGWSPLAEAISYGDRQTISSLVRKLKQQAREQMERRRPDLIRALAQIQDFYMELKWDFHSWVPLVSRILPSDVCKIYKAGSGIRLDTTLVDFTDMKWERGDISFIFQGEKPPSESLTVLDNKAKVYQRVRYEETENEIEDEVDILMSSDILAAQMSTKGIAFTRAQSGWIFREDRKETVAGLYRSDIYTITGLVLESRKRREHLSTDDLQKNKAIIESLTKGNTQNLDTNGEPTRVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W8</accession>
    <name>A0A835G9W8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000261">
        <property type="protein sequence ID" value="KAF9410489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="142" mass="16334" checksum="381A54026855D503" modified="2021-09-29" version="1">MLLDKRLRILCADEEVILNINDNCDDSGARVMMPNYVFINTIRGLNILYNNNICSKRYVYKNTKTMISYSAGVNILLFCDILQLPPVKGNWCFIQPSWLAAEINLWHQLSVCALTINMRHKMMPNSSTCQETLLTELLRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA92</accession>
    <name>A0A835GA92_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
            <shortName evidence="2">SF3b5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_012003</name>
        <name evidence="3" type="ORF">HW555_010266</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000248">
        <property type="protein sequence ID" value="KAF9410749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000447">
        <property type="protein sequence ID" value="KAH9637390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA92"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9637390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9900" checksum="85608B7090BE60CF" modified="2021-09-29" version="1">MGERYNIHSQLEHLQSKYIGTGHADTTKYEWLTNQHRDSCCSYMGHPDLLSYFAIVENESKARVKFNLMERMLQPCGPPPEKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAE1</accession>
    <name>A0A835GAE1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_001473</name>
        <name evidence="8" type="ORF">HW555_009555</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Elbow/Noc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000215">
        <property type="protein sequence ID" value="KAF9411726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000845">
        <property type="protein sequence ID" value="KAH9630003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAE1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN ELBOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9630003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="419" mass="44350" checksum="3A8EC2E6BCF614EB" modified="2021-09-29" version="1">MLTSSNQYLRPDYLSPLPTTLDAKKSPLALLAQTCSAIGADSPNPKLISAAEKASKKYDDKTHIPDNKPSFKPYESCLTAREKTRTPDDRGSVNASSKTPLSSKGSASTTPVQARCASNQSSSSQRTPPPAHRKTPSEKSDERSSPLHGSPVPAKANSDSISISSASKLPYTPTSLSSSADTKEHSSFKPSVPVSSSAFLGGLPHSGFPLPMDLMTSSLMAAQHHALKNGLNPYLAYARMKAPGSDLGICRDPYCTGCSLSSHLLKSAVCPAGCAQCDHAKTPFPLPTGHPAAAAYAHAQLAALAAASQLPYVCSWMAGDSAYCGKRFATSEELLQHLRSHTASGESSPSLSMLSATHPLLQRTYPTPPLSPLTPRFHPYSKPSHLVSSPPLPFPLPPHPSLAAYFPPYPLFGPRPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAG6</accession>
    <name>A0A835GAG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_003582</name>
        <name evidence="5" type="ORF">HW555_008789</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000178">
        <property type="protein sequence ID" value="KAF9412786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000357">
        <property type="protein sequence ID" value="KAH9639051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039303">
        <property type="entry name" value="CCDC50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029311">
        <property type="entry name" value="CCDC50_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115">
        <property type="entry name" value="C3ORF6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15295">
        <property type="entry name" value="CCDC50_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="146"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9639051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="442" mass="50457" checksum="57CBFC45D50A713C" modified="2021-09-29" version="1">MAGFQTSDTMPKFGHVTDLREQWLVRADGALAHRLQDREISSHLCENRYRNQLIREDFPIALNEQRDIEHEVHLRELTRRRQAEIDAEIAREMAEINLRRQRRQQSSDMLQQPSSSRAAPPAPLPATTVPSEDIDPEELGLSPTELEEMRRRLEQEEKDARLARELSHEDNNQDALLADMRCAVEAQDGELARLLQEREYKKLQRAKEKARQKALLKKQQKMAAQQQGLASHLDSEATLTQQATLCDAYSNPRDMIRENRLRLCKSVDSDLHYVEPFEKESIQSKASALQSLEMSNQYYSRQPEAGTSGSNLSHAHSQSIDDKRVPSNQNSIQHRQPPPPPATSKKPRFPDPVSIRPASHYPTEQSVPESIPPPTMAHSYSENNNLYSCTYPPDINPPHMAQDRHDNNKRLSVISDITAEGLAKKKSKQADINKKRKGCKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAR4</accession>
    <name>A0A835GAR4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000259">
        <property type="protein sequence ID" value="KAF9410515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAR4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="176"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="439" mass="51485" checksum="AD5D78DB966F5555" modified="2021-09-29" version="1">MEKKCEFEAMWNYSLMFDNSLRSSIIIVAEIVSFLPFKMNDEMCEPNNQYICPNKISNKLEQCISDIAKRNGFVKYDIEKKEFCTNGGSYLGLLYEIDINGHTNDGEKEINIFVKSILPGDIDLQMLSVRDVYETEMFAYKIIFKIFDELQKEANVPVEERYKTVKSYEESDAEVILMENEAKKGFSTGHRMDVISLQFAEMAIAKLAKFHSLSFVLKVKRPSFFEELEVKTRTSPYNTGDKWQSIAQNIIKITLDNIDEGIKERVEKFCENIGDRITSCYENESVRRSLCHGDYRPNNILVKKVDGEISELIPIDYQMMYYGCPVVDFLYFIICCTDKEFRQRHLLHLKDVYHKTMATFLNYFDLDVNSFYSREDFEKDYEERLNSGLVLALVFLPFVFASEDDVPDLTKDDRDMDKFNLNVDKRYKNQNTRNNRGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAW4</accession>
    <name>A0A835GAW4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine-dependent NAD(+) synthetase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000245">
        <property type="protein sequence ID" value="KAF9410803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAW4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="79" mass="9100" checksum="242985401A38508B" modified="2021-09-29" version="1">MGRKVTVAVTTLNQWALDFEGNMNRILQSIQEAKEMGALYRTGPELEICGYSCEDHFYEPDTYLHSWQVLAELPQICDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBA4</accession>
    <name>A0A835GBA4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin maturation protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin aminopeptidase ACTMAP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_008346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + N-acetyl-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:74579"/>
            <dbReference type="Rhea" id="RHEA-COMP:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:18395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64720"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
            <dbReference type="ChEBI" id="CHEBI:193599"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:74580"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ACTMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000159">
        <property type="protein sequence ID" value="KAF9413454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBA4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040043">
        <property type="entry name" value="ACTMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631:SF1">
        <property type="entry name" value="ACTIN MATURATION PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631">
        <property type="entry name" value="UPF0692 PROTEIN C19ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21646">
        <property type="entry name" value="ACTMAP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9413454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="29641" checksum="A5F515F2B3727BCC" modified="2021-09-29" version="1">MCTIPPPPPPPTLPNINSPTNVQKNGEGNQPSFDPEICTWASEHPELREACFKNRICYEKPPFKYKYRYFESILQIGPTCGLVALSMAVNGEASPDELLSIAKLEGYTSNGEMFSCKNMVKLTEKAYSLAEIDNVNCTLKQGGLYSSETIERLLNGAVLLVPYDADCNHSPCLKNGHTAHWALVCGIIIVNDPGDDYISDQKNVYVLSRHGKSKYLSAWNLYDLAQSNNNLYEFSPKKGADGLVYILPEGGIGGENGLRDQFLIFEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBK5</accession>
    <name>A0A835GBK5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000243">
        <property type="protein sequence ID" value="KAF9410861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="881" mass="98389" checksum="1065EBF136B10B33" modified="2021-09-29" version="1">MAEQRPEPLSDDFLFSMSSSTENRLSYASSPESDLEVSPPPAPRLVKSSSDPSIATTQDNMDRDDDINHMNDAVPPPYTQGGYGDSKYGFSATTNGAPTNGVNHNQTHSLGNNEAPPYQCNPMTHSPPHSPLYGTVPELPPRGTVSRPAGGVLLPAPPPGRPPHNLRHNTPGNRPSAQERLFGPPKDPGSDEAATYTARPTSMIIQPSQGQGSLDRHRHPSNLQSSYDGTSSYDYTGTTNNGSGVGSCRLPPNAPDDLKVAPPSINKMEPPPPPNPTAMSQSNMTQSPQRNSNSHEHNSLDYRSPDNNYRPPEYRSPQTNRPPPMNGNSPHTPMHARGPSLPNVPTNDHAKYSGRTNSASQADYGGRGGAPVPPYKPVPPPKPKHYRPPDNSHHPRNGSMEPPPAGPPGPRQPAPGGFPGSPHYSHQHSHSQPHRPHNHNNYQQQNMYGGQMPPQSPPYSGPPSHHRAINLPHNPHLIDLAGSREQRGSAFELYRKPQHMHNLSSSDAMNSSVERDETFSPKTKKKLSKKPSFIKNAVLDLFRSKTKNSQKVSRQKSLCESDLQQRHNVPQMPMLRREKSDLSDMSIHMRNQQIRNQMLQRSNSSSCEKPVLKPILKRQSSFCDERNGSICTVRDYDAKPVMKSLRRQNSMCDIETEPKVTPLLRRQNSLIEYNRRGIYGQSPSFNMITKIDPIYQRQQQVKHEPFHPTQPLPPEPVYQSKDHLVYDPIPKPRRTYTSVYDTSTENPYASRSEMSNQSFENPYGNKQTMEMPLMDPPYATRAECVRESPYATRAECVRENPYATRADCAKESPYATRAECVRESPYATRAECVRENPYATRSECIRESPYATRADCIRESPYASREECTRESPYTNKQDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC74</accession>
    <name>A0A835GC74_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000229">
        <property type="protein sequence ID" value="KAF9411301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="183" mass="20325" checksum="EA6A1E0E80B143D5" modified="2021-09-29" version="1">MQLDHLNVACKSLSSAGRVCPASRRAASRAHVAVRPRPQLGIVPSFGVHIHTLDHLNVACKPLSSAGRVCPASRRAASRAHVAVRPRLTNVSNDLICFVLVFALLIKVDSMAHLSDGELSLRIRAEANMKCQVKREELVPLRRIKSGSYMKQFVKASIYDKEQFCSHLEASYRIDLDKCLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCH9</accession>
    <name>A0A835GCH9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCH9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="16511" checksum="4278895B7A7B547B" modified="2021-09-29" version="1">MELPSEAWRVKVPHTLHPKSWHPGRHTKDQNVSKNSEGKQNVTWCLFSRKKKKCYEEESPSLLSLANNLNRNCCRCCWIFVKYVKEVFRCVYCLLNFQLPYMCFENMFCALVDATFATIVDLYCLIRASWRAFNNCPEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDB6</accession>
    <name>A0A835GDB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000117">
        <property type="protein sequence ID" value="KAF9415130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDB6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="71722" checksum="1A40D2F5D8C8C1F1" modified="2021-09-29" version="1" fragment="single">MHPSSTFVGYQKSFYKKHDNPFCGGLDGCKLEPYENLGEVEKRLFLLQRLSKSFQARRLLPDFSFKANQLQHVFLGTDNKLTTTRSVLPLPYPSALINEWFYRLMSFFCDTVAKLSPRHRIATRQSEIISSITTIKVNFNKDSDSRKNAEYIKKRLGALDALWEEFEQNHSRISDHASEADEYFRLNTYQVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQRTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKLHRYNNEQALFTHQIEIFLNQPNIQKQSSSEIKRLYDTTTECIHAIHNLGVNTNAWDPLLVHLLCKKLDTDTQTDYREARVEPRKLPKLDELMTFLEGKFTALEQITKYDKEPATSIKRTPNPKVQNNYYKYNNYKGFNHRNYQAQAIHISKCAVCNLNHNRNLFSCKKFINMTPDLQMRIVTQSNICKNCLFSHDGNECTSTKRCKSCQGNHHTILHEAALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQSKGLVSIDCQSIYGDYNFTTEALVLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDG1</accession>
    <name>A0A835GDG1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apoptosis regulatory protein Siva</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000181">
        <property type="protein sequence ID" value="KAF9412668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDG1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10725" checksum="DBAFE1855558884C" modified="2021-09-29" version="1" fragment="single">IIYDMAKRANPFVDDFIPQSKVHVGIKQFNNNQDRLKQVDNKLRLKQCTCGSNVESQCAYCEVSLCGGCQHMCVHCERSHCLRCIMIGYVLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEV7</accession>
    <name>A0A835GEV7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="168" mass="19487" checksum="DB1C19E3EC408152" modified="2021-09-29" version="1" fragment="single">MKALIGLLLGIGVSRSGRRNLNDFWDNKGTGLQLVYCTMSINRFRFLLRVLRFDDLEGPFQQSNKVNDVVLRVLEPLFDLGCTVTMDNYFTSLSTSLDLLKKSITVNPSLIVRKSSEMETEAFNRELLIDEIEKRPAMWDMTSSDYSDKNLRRRAWEELVNEEKKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF83</accession>
    <name>A0A835GF83_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_006140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF83"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9416565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="513" mass="58488" checksum="1E7ABED9AC2A812C" modified="2021-09-29" version="1">MIVIAVVVVLLITLYFYGTRNFKYWEERGVKHDKPLPLFGNNLQGYLFRSSMTQVADEVYKRYPNEKVVGFFRSSRPELLIRDPEIAKRILITDFAHFFERGFTPHKTVFEPLMQNLFFAEGDLWKLLRQRMTPAFTTGKLKAMFPLIVERAEKLKLRALAAAAEGKSLDARDLMARYTTDFIGACGFGLDADSLNDEDSPFRQLGVKIFKARPQEIMKAIIKELFPEMGRNLKIWTRVENDINELVGEILRKRDYKPCGRGDFLDLMLECKQKGVMVGESIQNKKPDGTAETVTLEFNDSLIAAQVFVFFAAGFETSSSATSFTLHQLAYHQDVQKKAQEEIDRVLAKHDGKLSYDAVREMHYLENVFKEGLRMFPSLGFLLRQCTRSFTFPELNLTVDEGVRVLIPLQSMHNDPKYFPEPDVFRPERFEADEFDANNKYVYLPFGGGPRACIGERLGLMQSLAGLAAVLSCFTVEPGKETVRHPVVDPLSSVVQSIKAGLPLMFRERAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFC7</accession>
    <name>A0A835GFC7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000141">
        <property type="protein sequence ID" value="KAF9414150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFC7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="3">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="21488" checksum="A896D54F802483C9" modified="2021-09-29" version="1">MPNECPPNEEYLLCGSACPFNCSNPQGPVLCTDACAEGCFCKSGYLRNDNGTCVTMDQCVGKDEVCGPNEEFLSCGTVCPLTCKQPEPLVCGIACGMGCFCKSGYVRDTVNDKCVTLDQCPVEQCLNQNEVYDLCNAACEASCDDPEPICTKICKGGCVCAPGLLRNSAGECVSVDKCGNYTDGALSQYMSVINNINKILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFE7</accession>
    <name>A0A835GFE7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000108">
        <property type="protein sequence ID" value="KAF9415559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="69" mass="7655" checksum="486E91DD3739F992" modified="2021-09-29" version="1">MGIPRAVLMLLAGIFSLFGLYLTMAESALHRLYMILLAIFSILIVSASCCKKKIPCTGRAPCRRGPYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFV5</accession>
    <name>A0A835GFV5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFV5"/>
    <dbReference type="OrthoDB" id="7425459at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10899" checksum="F49FC6CBCE3A31F8" modified="2021-09-29" version="1">MSFAIIVSDSEAKYNILLALNIIGVIACVGACVLLVLSALGIIFVEPNFSPVMAEHLKYFYNRTFHLRSFDLRVSPIEDSGWFFLNHLDMLVMNSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG66</accession>
    <name>A0A835GG66_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U3 small nucleolar RNA-associated protein 18-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000142">
        <property type="protein sequence ID" value="KAF9414112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG66"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49119" checksum="A594DFF0D5A67F50" modified="2021-09-29" version="1">MKRKSSEIQDAEDRVSQLLFNKTKRFVENLHTKTEEEEVSSDLKPAWVDEDDENFGANIIPNIKSTGLYTEKLKQKYETLMGTPNWANLNNKSKTDEEDDEILRTVGHLHKKKATHLPKDFLEIKKFPLINAATKNEGPIISCVEFHPKVSATLVAGHSGAVSLFSIGADVNNKLHSFSLKKWRISAAQFSPDGSEAFIASKNNHTYCVYNLVKAEPKLVQLPRAVKKPVIFKLSSDGKYLATSDGFEEVYLICAASKELLKSLKHNSNIASLAFSHDCTQLYCYGVEGQITIWDLSTYRPLKKFYDHGCVTASCLTLSKCGKLLATGSGEGIVNIYQTENLNIPEPIPSKVISNLTTKITNLNFNSTTEILSASSAYYPNAVKLVHIPSYHVFVNFPCPKLNHHQIDTINFSPNSGYMALGNNKGSAFLYRLKYYKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGH2</accession>
    <name>A0A835GGH2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGH2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF47">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="893" mass="99007" checksum="DB48B56E0C2C55C9" modified="2021-09-29" version="1">MIQVDGFKRPSPSPSRSSVRSDSRVFRQPRVITVNRDAATMVDGEASGQTTAAGAAPTDWETRLSQNAAHFRSRTFSDGFIRNTSLELLLGVDCEACLALAAQRQCLDEHISKHDFDLVCNCNVQQNNFVNCHRNVDQRGHTLNIYDLERIKRDTGRSQLTIGSHRSLDRKYNKSRTIGVSNYISKQLISYDPRNTLVQKIKRKLSNLKKMGGEAISKKHQNAVQLAEITSGSTSSLKKASMLSLADKSQRRVNSQSCIFTSSGYQAKDDMKSNVSTYANFSGNVDQCFDKLRDYNLSSDVNRRTSQKMIKMRSFDNNDILITRNSPGLERTKFSTLDNRSRCKSIKRQMSYNDFPSERFRDRLSETWTRDESTMESRSTRSDLVDDDAQTFPEGDVMAMSGPRGAHALCTCEAPQDTRLPSIFYDTHGKKRATPAPDVTERGQGGRVSCTACKSPQWLSTGTTSTTSHSSTTTGNSSRLSLWHRRWCCVAILVLVAGTACVAGPLALRAPPGAPLHERLRLAERLLHDTPLIDGHNDLPWNIRKFLHNRIKDFNFDEDLRTISPWATSSWSHTDLPRLKQGRVAAQFWAAYVPCDAQHRDAVQLTFEQIDLIQRLTDKYHPQLTLCTSAEDIVTAHANHRLCSLVGVEGGHAIGGSLGVLRTLYQVGVRYLTLTSTCDTPWAECASGDKPEPSPRGGLTPFGKIVVKEMNRLGMLVDLSHVSERTMRDALAVSRAPVLFSHSSARALCNVTRNVPDAVLRLLAANKGLIMVNFYTSFLTCKDTASVQDAIAHINHIRDVAGVDSVGLGAGYDGINYTPQGLEDVSSYPLLFAELMEEGWSIEELKKLAGLNLLRVMGAAEKVARELAAARVAPYEDVAPKPFDAHNCSSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGJ2</accession>
    <name>A0A835GGJ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000118">
        <property type="protein sequence ID" value="KAF9415093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGJ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032516005" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="30853" checksum="7CAB6590AEE4F667" modified="2021-09-29" version="1">MIRLLLLLTCAVGVWTFKIQSVPSCGVEASSNLIHHNPWLVYIEYWRGDYRTYVRCAATLVDSRHIITAAHCIRTPKFTRLVARLGEYDLSKIEDCVDGICADKIVRIDVEKVIVHQDYDGRSHDIAILKLADDAPYTDFIRPICLPSGELRMDTMFAATGWGEIPMQGYYSSTKKIIPLPLWGSDECKAAYINLIVPDNTICAGGEEGIDTCRGDSGGPLVRYEKTAELWGVTSAGNSHCGTKGSPGIYTNVFVYLPWVKDAMAGIHDDKAEKFDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH02</accession>
    <name>A0A835GH02_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myelin regulatory factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_007522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000128">
        <property type="protein sequence ID" value="KAF9414661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH02"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NDT80" evidence="8">
        <location>
            <begin position="145"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="9">
        <location>
            <begin position="453"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="6">
        <location>
            <begin position="145"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="804"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="903"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9414661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132642" checksum="0A5E7E027B7B7625" modified="2021-09-29" version="1">MSSVGEGCYAPQAIDPRRTGGHQLPESPPDSGSENPYSPSDPQVSHAISLPQTVLSSDYMLVHDHIPTQEILQQNGDYIYEELKTDNIDGLRSNLSDVVVLPQDSNIVELGIRTVRHDLGLGDVYQNRYSQMRVDMPELEQGMINPQLVALGHETLTPVYTSLQEPSTKKRKHSQDTSQVKCEPAALSPESVTHVPRPAPPSVDGSEAGDDAPLQCIRFGPFQQNVWHSLYDCNLKPLQPPSYVVGADKGFNYSQIDEAFVCQKKNHFQVTCQIQMQGDPHYVKTGEGFKKISNFCLHFYGVKAEDPSQEVRIEQSQSDRTKKPFHPVPVEIRREGAKVTVGRLHFAETTNNNMRKKGRPNPDQRHFQLVVALRAHVGHNDFIIAASASDRIIVRASNPGQFESDCTESWWQRGVSDNSVHFTGRVGINTDRPDESCVVNGNLKVMGHILHPSDARAKHNIQELDTAQQLKNVQNIRVVKFNYDPSFAEHSGLLGYDPTRPTPQLDTGVIAQEVRRVIPEAVKEAGDVTLPNGDTIPKFLVVNKDRIFMENLGAVKELCKVTGNLESRIDQLERMNKKLCKISILQRRDSSRSSISNDSRFSAMSNSSKSLYSDGNISIDQIRDIARNIRKHECCHKLSHNSPKYTRKQCKNCHGNYSKYGKYYNYNKTCVRYHSNKMEKCENVENPTYTDSNIQKYPDDSYNSSMSKKKDTCLWLKSDDNFSYSNTKLGFCCRKEYGDTSSELISNNLVVMSALYFREHQELISMKEIRLHDKLHYPHYGKLNNEPHSHRAPPDLNQIQNLKASQHTASKKTAKEKGPHKTTQEYVTTAPTESPHTISTSSHPTKTYDSNLINTVPTLQSLQLQNERPISLSRRADVIGGGCLFTSNTNNELDPECQSPCGLEPPQTYDNQEPLERKPEKELNDTFARPLEPLSREKLPSMPGVIPEKNTTESLKTEPESLRNENDSFKKVENLREEIIANSLDGSKQNGTEMGSRMKRETREELKSSSEEMILSEQSHENSGPHECDTVRVGISSKSIINSSLFSEYVCGNNIYNYSYTVPLSHCLSHKHVDLTFRSSKIKEYRICDVKCNYDSSKSCSSTKDPQKPPATEDTWSIKMALECNVDRMLKIRASFSTSRMRFPNKELCYLTPEHKYPFIEYNIRIHSDCHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH07</accession>
    <name>A0A835GH07_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH07"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38624" checksum="817DAD1DD0D4685D" modified="2021-09-29" version="1">MQQTQSVWKQNDDWKARYSKLYSSHRVFRLVPQQSENDDACRISFMSNEATPYASLLMRTRAARLDNAIYGGEGKISPEITTLMSAQSDPHDSCINYIQSDDLGGAETKLLDMVRRKNREFEEEAQDKTLDLPQDDISDDPSSEACVHGLSMRMTERSVSRSRVSRVSTRRDMDIPSILAFETTVVPAPAPLVMPGLQKVSPPQNEELPRWSIRRSICPVCSQKWRDKSSIYNVKSSGLKRYSSADLPSVIAPARLRASITMAYVPRPALAAVDESVGVGRAMRNTSASWQLTRARRFRIPKPQMPSPEATAPPISTAPMARKDLDIRVNRFLNDEGITKYLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHE1</accession>
    <name>A0A835GHE1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear hormone receptor HR96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_007125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000116">
        <property type="protein sequence ID" value="KAF9415148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHE1"/>
    <dbReference type="SMR" id="A0A835GHE1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000035">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="330"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9415148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64695" checksum="DFE20650A1901744" modified="2021-09-29" version="1">MDNNSDKKDDPSAQKKEVLSSLQKICLVCGDKALGYNFNAISCESCKAFFRRNALASKEFKCPFTNNCVITVVTRRFCQKCRLEKCLSIGMVKEFIMSEEDKAEKRRKIEENRARKRQRDPDDAVTSSKNVKRDEEGDTGLIPLQDTVIQYDTLSTTCSPSSTVQSPLTSDLEASLHSPLYNYTPAQPVATTEQPYPMKVYPIDEKSMINRGVYDQRMLDSYNMYENVDSNNIYPVEAPKQNTIRSILTNSDKPPAREARPQHVCEEIPSTSNNPDVNKARDILQDVERIEPNSMESILCEAIKLEFEAYTSVSPCSGSSRELNEVERAKLNELIVANKALHAPIDDDVTQLVGDTASSAGFKGDGKHDPRLITIVNLTAVAIRRFIKMAKKINAFKNMCEEDQVALLKGGCIEMMVLRSTMTYDGQRKQWKIPHCQEQFGSIRTDVLKLAKGNIYRSHDSFIRSFEARWRTDEHVILIMSAILLFTPDRPKVVHPDVIKLEQNSYYYLLRRYLESVYPGCEAKSTFLKLIQKILELRKLAEEVTGVYLDVNPIEPLLMEIFDLKHHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIJ9</accession>
    <name>A0A835GIJ9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIJ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14546" checksum="8A37E681791502D5" modified="2021-09-29" version="1">MQLIELFQSKPLLWDCSIKQYKDRNKKNDAFEKISKVPNIPKKDVETKIHREKKDVGKKTTGSGAIEKCKWIYYEPLEFLLCGATTSVLKKMDEREKKDPFDIYGEYIAAELRSVKDDQALTQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIM7</accession>
    <name>A0A835GIM7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIM7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="162" mass="17336" checksum="3041D7ED12A13413" modified="2021-09-29" version="1">MKTSLECERAETAESGGKGRISFSVDSLLGGKQDAPVKDTAADTNSNDAESTDAAPETDESDVDIEDVDSNADDREERENGHDGEDLETRGGVVVPQPLLPRLYQGPPPHSWPFGAFPWMAPNPMFRGGSPNRALALGCACAFEAFVKLVGSPRLEVELGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ34</accession>
    <name>A0A835GJ34_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_005114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ34"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06248">
        <property type="entry name" value="M14_CP_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032748536" description="Peptidase M14 domain-containing protein" evidence="12">
        <location>
            <begin position="16"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="121"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9417969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="430" mass="48923" checksum="9CBA021878813FC9" modified="2021-09-29" version="1">MKWFVLIGILSVAFAKHEMYKGWKSYYIGVSSVDQSKALGPLIQKFELDFLSHPAEGREGMVLVKPRHQAAFVQELEAKGISYRIHADDVKEKLDYEDQLIEAQRKSTTSRNGGRQLPYDNYQELEVIEDYLDYIGETYPDVAKVVTGGHSFNNHPIKYVKISRTNFEDETKPIIVIDGTIHAREWITPPTVTWAIHKLVENVTEPDLLDRFDWILVPIINPDGYKYTFDKDRFWRKTRSFDTHPLSLICRGVDANRNFDFVFNTVGTDWSPCGETYPGTHAFSQPETRVIRDILHENLARIALYINLHSFGSMIMYPWGHDGSLPQNALGLHTVGIAMANAIQNKALPHFPKYVVGNSGLIVQYFSSGAASDYAHYIGVPFSYAFELPGLEQSYAGFHLDPKYIGQVCQETWEGFVVGARRAGDLFQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ65</accession>
    <name>A0A835GJ65_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_005751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000078">
        <property type="protein sequence ID" value="KAF9417053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ65"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9417053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="460" mass="51944" checksum="EBEFF7B4146F8EA5" modified="2021-09-29" version="1">MVIRNNSLAYKIWKRPDVQPHMKVHIFNYTNWERVKEGLDEKLHVEEVGPYVYSQQLERVNIEFNGDKLSFQERNHFQFLADKSNGAHFDRVVVPNLPLLGVISKALSMNLNSLGQLTLSSAMTWANHPNAFAELPVHRFLWGYDDSIIDTAKPFLSLGGQLKFEKFGLLVTKNGTVSERFTINTGEYDKDKMNIIEQFDGKDHLTFWGSPECNSIKASDGSIFPPSQLDKATTLHVFYPNLCRRLPFQYEKTIEIVDGIELYRYRMPMNVFDDPGHNPENQCYCEIDTATCPPRGIINVTDCTMGAPALVSFPHFYLADPKLREDIVGLKPDPLKHDSFIDLHPTLGIALSGKSSLQINIQVRKSDMFSAVKFLPNGLILPVAWIEMSVEELPEGLRTLVYHGTYSTAAAQLGLTVICVIAFIGSGVCLLCTFARRKQKPCATLKVKIPTEIELKNQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJA1</accession>
    <name>A0A835GJA1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000060">
        <property type="protein sequence ID" value="KAF9418129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJA1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF123">
        <property type="entry name" value="GELSOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032658177" description="Gelsolin-like domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="67"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="314"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="401" mass="44094" checksum="084294CFC99B7DD3" modified="2021-09-29" version="1">MKLLGVILLTVAAVSAIPRSATRQQPVTAHITSLSDKDARSKARVHPAFANAGRVAGVEVWRIQDFEPVAVSAADFGKFYKGDSYIALRTTADKRNNLSWNIYYWIGSESSQDESGAAAILTVGLDDKFNGAAIQHREVLGQESEDFKGLFPSGLQYLSGGHASGFNHVVTNAGAEKRLIQVKGKRNVRTRQVDPLISSMNKGDCFILDIGNEVYVYVGESAKNMEKLKAMSVANQIRDQDHNGRARVEIIDQYSNDVDTQKFFTALGSGAKDLVPEASAGGDDQAFERTEEQSIVLSEVSDSSGKVRVTALSKPYTQAQLKPQEAYILDTLTGSIYVWTGKQATEREKTEAMNKAQQLLSSKNYASWVKVLKIPQGTEPAIFKQYFTTWRDLGMSHTRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJF4</accession>
    <name>A0A835GJF4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="308" mass="34918" checksum="1E0B3383926B3FDC" modified="2021-09-29" version="1">MDDFFKNIRSTPINIDNIINADPIMSEIKMDESKSLKEVENKPEDNLCQLPQGDNINQQIKYDESVLHAQDAGEIKNILEAKEAEDLVSQANNENFKGENIDIVENSKDDISIKTPCIGEIELVENKHESSTKPIEMSNGIKDTKDEVTHFRSTIYDSVMIKTNSLLEIVTNRFNGLVKEAQGPNEEKEINITSGEYVSMDDKPLNYLIGKFDNPVTQPVDAEELNEKLNEISLQSQAALEELKNQSIKIIDTARAQTNKVIENARYNVNMFTKPLEEIQHQQKSVDETYDEDIEKYVGPGLVTDFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJG1</accession>
    <name>A0A835GJG1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000075">
        <property type="protein sequence ID" value="KAF9417240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJG1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="19122" checksum="F371AA543CE9D352" modified="2021-09-29" version="1">MTKLADNVNPNVYDKGSEREKTSEDYNEDIEDLFDEREIFDLIRNINDPEHPLTLEELRVVEESNIKVDNKDNTVVVSFTPTIPHCSMATLIGLSIRVRLLRALPSRFKVTVEVSEGSHVSEHAVNKQLADKERIAAALENKNLALPQQVKHLQVHVLTSSLSVGRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJY3</accession>
    <name>A0A835GJY3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="281" mass="31853" checksum="7515B70A4CDB0DC0" modified="2021-09-29" version="1">MENMNCNYIAPTCTNVPADIAKNSTIVEEGPRLSFSLKTKYQFAINDTVSRKYNIADICPLCNALVRLYYVHYTAKLFMCENIECEYPFGGDFTVYSSDDDDFFMSEFDSSSLKRKRGSTATQSITQTTTGTSTVGTSSELSTSEWSDMNRINQAYDSDDSTTLSKIITRKSNKRKTDKNVKKQENEEMIKQNVEKIKELNKVLFDNDDDLEIIRNEKWIKNLSSMQSSTGAKLVTEQELLKLKKIEQKRVQELKIDIEASTDSMSSIKIEIGGLGTNINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKR5</accession>
    <name>A0A835GKR5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium/calcium exchanger 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na(+)/K(+)/Ca(2+)-exchange protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 24 member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HW555_005320</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">BAW_Kor-Di-RS1</strain>
            <tissue evidence="28">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKR5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF70">
        <property type="entry name" value="ZYDECO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="27">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="27">
        <location>
            <begin position="371"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF9417613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="545" mass="60403" checksum="7B3AD7F16837AC4C" modified="2021-09-29" version="1">MDKSLLVSEVYLRNCTPPAIDDFPAGLFTEQQRQHGAIVLHAFISIYLFLALAVVCDKFFVPAVERICQALNMTNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMVVPLDWWPLTRDCLAYGITVSILICIMHDEYVQWYEAFLLVMLYGVYICIMYYDKSIQNFAKERCCYTGNWNCVSDMLKKNEKHDNAVTADNELKDAKETSPVNKNDLSLERHQHNGNIKSALSLCPDKNEKNNENDSSQSVSLPAADGDGDKAKNTCIDMENKDNDVEVENSEGNESVVNVDDNNKEGEDKYVHSLWKWPTGRSWLTKSTWVVTWPIHLVFLFTIPDCEKPRFKNWFPLTFIMCIVWIGSLSYIVAWMITIIGDTLMIPDSVMGITFLAAGTSVPEAVSSVIVAKQGHGSMGISNSIGSNTFDILLCLGLPWLIKASLTPAEAGHYWVKINSMGLEYSAISLLSTLLLLYLTFWFNKFKLDAAVGRACLAMYAMFLVLATLIELNVFFPVNVRTCKRSELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKV3</accession>
    <name>A0A835GKV3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SPARC-related modular calcium-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKV3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16234">
        <property type="entry name" value="EFh_SPARC_SMOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF30">
        <property type="entry name" value="FI05255P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9417697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="64847" checksum="EDBC6622D777FE83" modified="2021-09-29" version="1">MSSVNCIKIFKKIALSTDIMNVNDLVTRLFFLTIIYIVGAAPDDKSSASSPVNNEACKARAAACEANAAHARRPVCGTDGRTYPSRCHLMIAQCNGPPVTIARKGPCVEGQSSCLIAQRYALNAQSGVWSAYVPRCRADGSYAAVQCASAGAAGGGCWCVTPDGKPLPDTSVRNGRPDCTRTGKSHTRRRSSVRGQRNKRTCTRTDRAQFNGNLIKIFSGEFERARTDSGSSPEPRVVADWKFRELDRDRSDALQKSEYRGLRRLIKKVVKPKRCARAWARGCDGDGDGEIAHAEWVACLLVNPEPPAPDFSLRFFMSLNADDDSGPEPEPADYEEEPPPDPSSVLPGIVRNSFAPDGSESEARREDEANDCLTDRQAVLDEQKAGGAALYVPECTGDGRYARAQCYRSTGYCWCVHQDTGKPIPGSSVKDRRPDCDAAPQHASPMRGCPEPMKSNFLRDLMSFFVSKMTTSINGTGPGDMVKWGASKEEQAATWTYVMLDKDKNKALERREWKAFHQLISNVEPLRRCGRKLPRYCDVNHDTKISITEWMACLEVTQGSQAQTTEATKAPSNPRRKGPNPLESFLKADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLN5</accession>
    <name>A0A835GLN5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLN5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="37287" checksum="51410EC01753B658" modified="2021-09-29" version="1">MPMLKDLLRLMDAKIFKPENDTHEKISPIRLLELQAARIKRLLLAFMISSQITCGMWALKPLFDDADRKFPFDMWMPVSPEDAVQYYIGYAFQLGTICISAYMYFGVDSVTFSSVIFGCAQIDIIKDKLMSITSIKGNRGSKEVDEALAKNYNKLVDCIKHHQAIVKFTELVENAYHSYLLFQLIGSVGIICMSALRILVVDWRSMQFFSILTYLSVMISQLFVCCWCGHELTATSEDLHRVLYKCYWYEQDVKFKRDLCFAMMRISRPLFLRAGHYIILSRQTFVAILRTYVLFLLRSFESNSVRKRDEARVLRRRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLY0</accession>
    <name>A0A835GLY0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="177" mass="19860" checksum="16B8569C38DEA9CF" modified="2021-09-29" version="1">MHARSLAQSNTPTVCEEEACRCDPFTRVICTCTRDYPEVTLRPDGAYRVPSTATGIIIDNCSRVTFLPDTVRSLIQLRNIELRNVDHVVINERALSWSPFSMLNEMNPGLRISITNSTVDEIASHAIQGRVNDVVISNSRIKVLKPFAFSSLTGVNTIDLQDNVLRTLKYRLLRNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM59</accession>
    <name>A0A835GM59_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_002363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM59"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF9">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="4">
        <location>
            <begin position="164"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="5">
        <location>
            <begin position="456"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9421682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="67172" checksum="219FBB55FB56F5D4" modified="2021-09-29" version="1">MLNAVIDKDRVGYFKATAVYYGRSQSRKNLTLPKIPKNLTLPRYILRNLESHRVYSFSHVKHYFSYFFSFAARLEREERMEELLANMKNHLEYLDSQYRGKQEAVITLQAKMFSGRGNSSQNTLHEVSLAPLSPAVQLLLKNMTGTKAASGLYTKHIQQLRIPFVYQLLPHLMNDPQSLKPAYHMSGGRSFCEIVVGVPTVKRDKESYLMVTLTHLVTELSPADVNNTLIVVMIGETELDYVLQVARQIETMFPNQVDSGLIEVISPRESYYPDFDKLPITLGDSRKRIKWRSKQNLDNIFLMAYAQSKGTFYLMLEDDIIAKKNYIQTIKKFTATTTVSNPNWIFIEFCHVGGIGKLFRSAELIKFISYAQIFYNNLPIDWLLESYLADRVCNLEKAGKNCGAAKEKIRPKFKPSLFQHIGLYSSLKGKMHKIGDAKFRTVPKFFPHTDNPPLRTIKTDIIEHSVHTLQKAYAGRTFFWGLKPKKGSFVEFWFEKPIVMTHYVFRSGNPDHTMDLFYNTTLEVLPAHNHSNFTVIGAFDEFGLAEGNLSMGPIIAIRLSVQRNSRFWVILSEIELRVSPAPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMD2</accession>
    <name>A0A835GMD2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_007941</name>
        <name evidence="4" type="ORF">HW555_002785</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000062">
        <property type="protein sequence ID" value="KAH9644853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMD2"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9644853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="15335" checksum="F0D851B02194B661" modified="2021-09-29" version="1">MPRRGRSASPPPAPQRRAAPPPAPSRVPAHAPPSTPAPAMAQPQQPSMFGQMAATAGGVAVGSAVGHVAGSALTGLFSGGSSSEPAQQQVQAQPPAQTLNQYQNQTPQGPCAWEIKQFIECAQQQHDLTLCEGFNEALRQCKINNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMQ4</accession>
    <name>A0A835GMQ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMQ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="20948" checksum="DD3C6058A460B0B8" modified="2021-09-29" version="1">MNVKNAYTPTGFEKYGCTCAVADYRVNFSVWDTSGTAAYDTVRPLAYQDARVFMLCFNIAEPETLHNAAAKWYREVRTHGGSAPVLLCGCKADLRHEKETLTMLSKLRSHPVTSEEALSVARQLGAMTYVETSARASTKGVKDAFEVAALAALGKLNKQQMKQQKQVGRSKSKRDLKAELKGRAKSCCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNB2</accession>
    <name>A0A835GNB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNF277 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="431" mass="52030" checksum="5CD8F20440029AC0" modified="2021-09-29" version="1">MSVKEKEFFGPLTLHEKTESPSIFKSEDVAECSCVLCEENFLLPSNEKDLLTHLFMKHRLVIADVNQIADLKEYLRYWRLRFKDQNLPYFCTTMLLDNKPDGTKSKNEEYYLLSDVLPEDKELRTNLQQTRLEKLLERHQFEREDKNYVRECLFCRNISTTTRANYLNHLYEKHNFHIAKPDNLIFIDELVNTIATKLEKLQCIFCEGNFKDRTILKEHMRKKGHKRINPENKEYDKFFLVNYVGDKQQRKQHYRLNKNHNVKKTVDFENDSYVDSDPEWSDWTEENGPLITCLLCEHTEKEYDKILNHMEKQHEFFFMKVTEGMDFYHKVKIVNYIRRQIHLKQCLSCDTKFNDAKNLEKHLKETKHWELCKEKWDQPEYYFPTYEDDLFLCFIQDDDESWWSNDDQEIEKRNSMSDSISKEMAMAVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP33</accession>
    <name>A0A835GP33_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP33"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="188"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="430" mass="49342" checksum="E7AF686E482B9696" modified="2021-09-29" version="1">MHKIQDRTQRILALVPVEHAPSDTSDKSDTNSDNELPPPSPSPVSSSAPSIDSSLERLNINSSPEPETTQTEGELLEPSDIFHAEALQLTPVLQEICPDTPSREPNYDSVPSLSSMISLPSEIGSPMPGPSSTRIKKTRARKQIAPAAKKTKKIPKFTLTYKWKKGIFRHRAMIEEIHEASVDFPDDDPLNYFYLFFSEDIFTDLVEQTNLYSVQQTGKSIQVSEDEMRDFISMHIMMGIVEMPCYLDYWSNKFRYGQIADVMPLKRYQQIRRFLHFNDNNLQDLDRYYKVRPIVEKIRRNCLKQENENKFSVDEMMIPYKGRKAGNRKQYMKDKPNKWGFKNYVRAGVSGMIYDFILYAGEDTFRSYTFTEQESSLGFGAQIVIALARTIKKKPATVFCDNFFSSPELFYILKENYGVFGAKEQLGGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPD8</accession>
    <name>A0A835GPD8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000040">
        <property type="protein sequence ID" value="KAF9419707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPD8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040373">
        <property type="entry name" value="CASZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451">
        <property type="entry name" value="TRANSCRIPTION FACTOR CASTOR PROTEIN MING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12451:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN CASTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1199" mass="135919" checksum="BF3EA7119A2CF3F2" modified="2021-09-29" version="1">MYRLLSALNHLDQARKNSLQTTVDYSRYVKRYSSTLECGSSYCKDLGYREHFHCMDCTARVFCKKEEMIRHFKWHKKRDESLAHGFMRYSPLDDCSERFSDCPHNRSQTHYHCIQDGCDKVYISTSDVQMHANYHRKDSAILQEGFQRFRATESCAAPHCVFAGQRTTHFHCRRPGCTYTFKNKADMEKHKTYHIKDEALSKDGFKKYMKNEACPYRDCRFSKTCNHIHCIRPHCNYVLHSSSQIFTHKRKHERKEQEMSFGLPTSVIQSALMQPGADLSMYSPGGNVLVDDDMSNPMMDSDYPHPFNPALVEEISRKYIETFNGGKEAEDKCNKCSAFNKHYHCLADGCKMAHSCHTTMVKHVMEHEQQNQVTEAYFVTYTRNNPCGNSACQHIRDITHYHCTWENCGAVILSSEEHPFRRLEHHRQHAILSPMSPNLASRFAPNFTPQLSAQLHPNMAAQLGQVPNLPNLPPNLAQLAQMAPSLTSQLTPNLQAQLNLGPNPGVVPQQVNPSSSLDEMFSRKRGRPPKNRVVEVYTDNIAPTAIFTSFKLPKSNQLPPVIQSPVIPTIEEFPRIKFQHFEVFTSPDTCSSSYPACQLRMARLHLHCFNCSFAGETHIIMETHMREAHGVSPLLEGFDYFASFDQCGGKSCFKNQLRSHFHCAQGNNCPAILTQYSALATHKHGRGTPVIKSETDHEKQFEEAKDYSLKERASVDSVSSMKEPNESFTPANFSIKSEFEREQDSVSVVKATGTFYPSSHLRSNTSSPSPRSIYDASPSKEMKSRMDYEQKKVFEPPKITGPTIPPSCHDQTCPLNKNSTGMNLHYHCPHCSQAYVDLKLLFSHMVKKHSNSMEPGPVGLAATKETLEREYPEISILPSTASSSSTSQAPSPSHSQRPPNPADQVQAVQSLLLQQYLAGGRKGSLQEQLKMQQQYTASLAGLPGLAQVALFSQGGSPFSLYPTMLYPPELLLEQSLLQGHGLPPGLDKEAEMIAKTRRTHTTRGPHMRVMKDEPIPEGYLRFRFNEDCAYQHCGYREHQTHFHCTRKDCGYSFCDKTRFVQHTARHERLDTLMGGDFQQYRANVYCKRPECPHASTFGTGQNKASHFHCLKCDFVCTDTNKVVAHRRQHQKLDSIQAAGFEKFPPSKGCGYEPQCIHSKKQTHYHCLQCGFAVLGLSQMTSHKYKHQEANLGPSTSGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPE6</accession>
    <name>A0A835GPE6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPE6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="255" mass="28911" checksum="E9B66BB1910B9C81" modified="2021-09-29" version="1">MPVSERMCGSKRERMMSPPGDRHKTNTINVFRNNKDCSPLSSFSQTFYKPSWSVHSNFIQLFTLELKTRTMLLIKVMSCLLPIIASLRTQRSSGTLVDFTDPKVQGHLDALVRMAQSCVIKVRATPKDVRAYFTNSSPVSRSGQCFAACMLEQSDVINHGKVNRELLVHLTSLVNGKNSRVVRKLNTVSRLCLDSIEGMSDRCQLASTYNDCLNENMIEFAFPLDIAEEAVRKMPFHLIQPKLPKVNQNTRRILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPN7</accession>
    <name>A0A835GPN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPN7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24238" checksum="9F9EC0ABF0C7C4A7" modified="2021-09-29" version="1">MRPKLDELEHSSTQRIARIRVFKFRVDYFTDLDETDFFARFRLSKYAVNQVHNFIKHKIMPKSQRNQAVPTKTSLLLTLRYLATGSYLRSAADFCGVSPPTASRIVKKVTEAIAQLRTVIIKFPDNLSTLQDGFYEIASFPRVIGALDCTHVAIKSPEENSCFILRNSTWPCPVSDWPLQILTSVRTVSALVVGGNGSNSFVTSSTTSVKKRQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPS5</accession>
    <name>A0A835GPS5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_003606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000036">
        <property type="protein sequence ID" value="KAF9420012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPS5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032482396" description="Takeout" evidence="4">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9420012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28444" checksum="8A5806D804250ECC" modified="2021-09-29" version="1">MCDRRYVLVFVLVSAASFVSDCTAKFAPDFIRPCNNTEPACLIKATQDAIPQFTKGLPDLGVPSLDPFVIDELPIQLPGIKVTFYNGKATGLRKCQVLNVEAYLEKNIFNLDVRCNITIKGKYTAVGRLLLFPINGEGDSKIKIVNSIIKLHINTKYFKDADGRDHFGIKNYKYTFDYGERIIYTINNLFKGNPELSNTVLQFLNENWRIVTEEFGQPVVDYALNVTVTTAKKFFDAVPYDELLYVPIPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPZ7</accession>
    <name>A0A835GPZ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPZ7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032669400" description="Lipase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="404" mass="45876" checksum="F5C31C222DCC11CD" modified="2021-09-29" version="1">MYIYILLLLICKVSNAASVEERGFWDLLGSLLNYSNSALVPEDANLSITELGKKYGYRVEQHTVTTEDGYILNFHRIPTRSRKVRPVVFLMHGLLDSSDTWLLLGPNKALAYLLADLEFDVWLGNSRGNKHCQNHTSLYNTDSDFWHFSWEEIAVHDLPAMIDYILQVTGMQNLYYVGHSQGTTTGYVLCAMKPEYNSKIKMMFSLAPEAWMGHIRSPLVKIFSPAHSVLAYLLSDFSADYAGVDFFNKISTFVCTIVPARCDNVLFALSGYETKINETFLAVILGHSPSGSSTFQFAHYGQLVESHRFCRYDFGRQGNLAAYNQSVPPDYDVSLVTTPVVIFYSAKDLLSDPKDVNILIKNLNNVRETIFLEDFTHLDYVYAQDAAHVIYNKIIRRIISDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQE2</accession>
    <name>A0A835GQE2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQE2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053032">
        <property type="entry name" value="BAH_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576:SF1">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="998" mass="109250" checksum="A81A04F84B020A7A" modified="2021-09-29" version="1" fragment="single">MRSQASKPLPKKGELSKPSFKNTTAKQAAKKAVSPKRVKNLVNKSLIKNTKKGSSKDDPSTSKNDDASANSDKTDTTPEAVKSGQCKAGTARGDSPTKKLKKDPKEKKDATKVGPDSVKKNGPKKATKVDKKTKPVKANVKKCVKGKKDIKYKINKDVISKASPKFSKAKTVIKKGNANNDKKKGTVPAKQETTEKDQQIDENKSTDITIKKELNTVIEEGIENSKTKTLEADKSDDKSDTKIVTDSVHSKTTSKPVGPPGNQPETPKTETERPPKFFTSARSPRTVDIDVKCCKNSKGNLSVSERFVSMKVETKVEDNAKDKSSNNTLVSQGPEIDVYTFTEKVDSPKSILSDFRSPVNKNIGRVRPIARVKGTVIDKKAESEKKKYSPHRPIEEVVKQLKNKRSEELNANQNQNASATSSVQTNPGNSETEAEEKPKPIVSKSYKMVARKSSITGKPFSPIKFLEQEAPNKSDKTEKPVKTNSNAKKSPVKSKKQTKKSSISDEEIDNSKFALNTKSFHYTSSEESVSESNDDNDTKESSESDSPKNKKAKNKKLKKNRITDGAKKPPSKELKELSKDSLIDLKESSALLGNEKPSKRRLKLLSMWSGPKKHRMASLNAIAKVHCLYENESRTHMELGLMKTVDRQVLPSTSKAGSPKKKENKSKETEKQESTSESEYEAKKEKKEDSSESSDDNPPQRSLRGVPGIRSAGKYWDPKSSTSSSEDSEQDTKKKATNSEKKKTPSKASSIKSDTEKPPAKMKKTAGVPVKKKRNRNEVVMDLKDMVVQKRMASLNATAILAASYEKRSPKSNKDDTTSDSCSDESYSQKSKNGVTSGVKSESKNEYEAKSESDESAVSDRKQKVEVIVNQDTDVTITGVYSTHHHEGFCTVSGMQYRISSTSHTQTTATANCEKEGCSREDGARYTPLSALSSMQPPADHSHSHPVGAEGSQKSSPPRSVAGCSPTLTPVPELGGLARRPGCSSAFSAPSSASHHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQI3</accession>
    <name>A0A835GQI3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="675"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="761"/>
            <end position="783"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="789"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="818"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="843"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1304"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="32"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="495"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9423517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1343" mass="153080" checksum="68B27FC4A2853F72" modified="2021-09-29" version="1">MEMPERNAVKPTVQQDLIQKVIGSFGKYHLWLCLLIFLTKFPVAFHQMAILFLSPKVSYSCSGSELNNTCPCSDPVYDTSVFTSTIISEWDLICDRKWLTSFTQTLFQLGTLLGSVFFGMASDRFGRKSPLLIAVVMQIACGVGAAFAPDYWTFTFLRFIVGMSVGGTMVTGFVIVMEFVGTQYRDVISALYQVPFNLGHMALPLFGYFFRDYTDFQLSISAPVVILLSYFFLVPETPRWLIAVKRTDEAIEVLERVAKVNNRPTDNIRADIEAYQASLEKHQLRKGNFFDLFRTPNLRKNIIAMAFNWLACSYCFYGVSQYVGQLSGNVFINVACSASVTLLGTLLAIPLMKVMGRKTIVITFHIICAVCLLILAVIPEGVGSVISASIGVVASFIVFLVVYLYCTEMFPTVVRNAALGFSSMAARIGSMVAPFVIGMRDTALWMPPVAFAVLPLLAAFVTLCLPETKGCELTTTIEEGEAELMGDFGRYHFWLCFIVFMSRYNVSFHQMAIIFLTAPVQHYCPGSNDTCCDNPVYNTSVFKRTIITEWNLICERDWLKDLTQTIFQFGVFCGSLLFGIASDKYGRRPTLMISIILEIFAGMMSSFLPDFWSFSFARWVVGFANGGCIIIAFVLVTEYVGNVNRDTVSTLIHLPFTTGNMIVAGIGYLIRDYTYFLLVISVSNVFLLCYICLLPESPRWLLVVNKTEEAILLIEKVAKINKLPTEHIRSKMEFYLFEHRTKKPRSTALDLFRTPHLRTNITVMSFVWLVCSYCFYGVTYYIGHLTGNIFINVLATGGVCTCAVIISIPLIKFYKRKTVVVFGNVICSLSLLTMGFVPEGKATLVVGCIGEMHSYIIFIVIYLYCSEMFPTVVRNAAIGICSMVARVGAMIAPFAASLHIYGKWCSPVAFGIFPMISAFLCLLLLPETKDCELLVTLEEAENLGRKIQISRSDNSLNFEESEARQCKPAGRRTMAVGLLLCIAWYYTILAGFFILYCPVMYLMFFSHKLYRKLVDSLFSLWELYPVALFQCCCDTQLHHFGDFVKPDEKTIIVMNHRTRVDWNYVWIALYHATQNPSGELCSCKQTVQNLSESNSVLDLGGKSKIKFVLKDEIKNIPGMGWIMQLNFFLYVKRNWREDQINLSQFVDYYQKLHYDYRLVLFPEGTDLSEENRRRSDKYAHANNMQRYEYVLHPRTTGWVALCSRLRESGLAAVYDVTVAYDTPAQTEMDLVRGKIPKNVYFYFKRYSIDKLPQDDTALKIWLEARWREKEQSLRKFHNDAKAGFLFWTIIDILFFYSLCNSVTFQFWVIYHGLLFIFITWYFGGFHNIQYKLLEKITIFVQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQI5</accession>
    <name>A0A835GQI5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="27231" checksum="B511233939B9754E" modified="2021-09-29" version="1">MEYQETKTPRKRVANFTAHEKALLAKLIKSQPIVESKATDGKSVVKKNAAWALITKEFNSNSNVHKRETITLKRAWDNMKAVIRKSYATERPNVPPLSPQPGPILSMAKEVPPMTMSEINNPHDSDSTTLNTVKNNKEEEVLEDFDNLDYSNSKKNALPKESTNRTRRPMDYIRREAVMRIKHLEIKKKLDIEILKTQLEVEQIKKKSALLEEERNKCLLEKTKIELEELKKLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSB1</accession>
    <name>A0A835GSB1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-ureidopropionase</fullName>
            <ecNumber evidence="6">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_001866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSB1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000008">
        <property type="entry name" value="Beta-alanine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9422468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="43380" checksum="0CC4428A4998D595" modified="2021-09-29" version="1">MAASSELQSLDLLISKNLSGIELQEYNRIHYGRTQHNELSIKESTQETAKENGFEIASYDFPTKKEETRSPRIVRVGVIQHSIATSTDKPLVEQRQGIFEKIRKIIEAAGEEGVNVLCLQEAWSMPFAFCTREKQPWCEFAESAVNGPSTQFLKDLAIKYGMVIVSPILERDEIHGDTIWNTAVVINEVGKVIGKHRKNHIPRVGDFNESTYYFEGNTGHPVFDTKYGKIAINICYGRHHPLNWLMFGVNGAEIVFNPSATVAGLSEHLWAVEARNAAIANSYFTFAINRVGTESFPNEFTSGDGKPAHKEFGHFYGSSYCTAPDGARTPSLSRVKDGLLISQIDLNLCRQIKDKWGFTMTQRLDLYADSLNKAVKHDFVPQVVSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTH8</accession>
    <name>A0A835GTH8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000008">
        <property type="protein sequence ID" value="KAF9423575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTH8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="35"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9423575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="34920" checksum="16B7250969D7D592" modified="2021-09-29" version="1">MIKSLRELQDFIKSKDNFTNFTNSSIVPDICKTEPCMLGVDEAGRGPVLGPMVYGIAYCPVNQTKVLQDLGCADSKALTEEKRDDIFTKMISEEDSLNNVGWIAEVISPNYISNSMYRRAKHSLNEVSMNSAIGLIKKAAESSANITEVYVDTVGPPEKYQAKLSEIFPNYKITVAKKADSLYPIVSAASIVAKVTRDHALKVWKFLEGLEIDQAGFGSGYPGDPVTKKFIREQIDHVFGYPMLVRFSWSTAELMLQEKAATCTFEDIDEPGSKKTNTKSISSFFAKPDEDKPRKRHKFFEERHLCVGNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTS9</accession>
    <name>A0A835GTS9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_004057</name>
        <name evidence="17" type="ORF">HW555_000799</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9424090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9633343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="432" mass="49840" checksum="002299E946BC22C7" modified="2021-09-29" version="1">MNQDAKKIANSLYGRVNAPPVERCRVNFCTDLEKSVLMSNFERRAWNQVGPDDEWNFYWASTQTCRNLFSVESGYRMNDNQIINHFPNHYELSRKDLLVKNIKRYRKELEREGNPLAEKAEVVLHGGQVVTRYVHLDFVPVTFVLPADYNMFVEEYRKSPQSTWIMKPCGKSQGTGIFLINKLSKLKKWSREAKTPFHPQLSKESYVISRYIDNPLLIGGKKFDLRLYVLVTSFRPLKAYLFQLGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGDYNNIHGGKMTVQNLRLYLEGTQGRAVTEKLFAAMQWLIVHSLKAVSSVMANDRHCFECYGYDIIIDNQLKPWLVEVNASPSLTSTTVNDRILKYKLIDNILSVVLPPDGVPDVRWNKIPNAEALGNFDLLIDEELLEKEESSSHGRAVKTKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTX5</accession>
    <name>A0A835GTX5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1673"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1814"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1868"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1687"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1727"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1897"/>
            <end position="1936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="2400" mass="263417" checksum="03846D4608245658" modified="2021-09-29" version="1">MEKPARYKAKSKKPAAKPKTAKKRKCDGPTCSMFLAELTRKLAMKKKQEEESPKNIVQTIIDSITNALPVKLSKKSPQKCLSPIQIETLQTFAPELTPKDTINFPLPTTTTSVIEDVSMEDIEISSPPKPGTFKMPKMPLVNSDILKASAATAERERKNQMQDQSVNTGTDHDVASEIAKHVGTLRKISLIAEEFNQKTAKNLKEIVDSVQEDLIKKLEEIQAEQKANQDKHMTITEDESVADNNEMESNAHNDEVANEMFKIDEFGQNITIDISNSKQRLSNGDSLLGPSKMGGLPMKMKKLNSIEKSKASHIPRRKSKKERYKENCELPRISETPNRSQFIPEGRNVQRVQMLINQEFCPDDRVAPPASVQSTRPIPTLGQIYGRINMIDSDRLNDWFMDFAPTNTTASNPTTEFCEGFNEDDGTSSTGASPANCHQQDLGKPKNALKMDKKDNLLNELQTANENVAMWLSSDVDYPTRDTESGYKTMSSNNADKPSIPSQNECRMENSNQSFSLGVLLDNNSNLYATPKVESECNDGRISLLKVQQAAVPSVSSEAEKITTADSIGAIPKSNISLKMSKTPNSGLKTMSSNNADKPSISSQNECKKENSNQSFSLGVLRDNNSNPCATPIPPNLESESSDGHISLLKVQQAAALCVSHETEKITTAENIGAVPKSNISLKISQTPNSGFNTMSSSNADKPSIPSQNECKMENSNQSFSLGVLRDNNSNLCATPKRESECSDGYKTMSSFNADEPSIPSQNECKMENSNQSFSLGVLPDNNSNLCATPKLEPELHSGFKTMGSSNADKPSIPSQNECKMENSNQSFSLGVLRDNNSNLCATPKLESEWSDGRISLFKVQQAAALCVSHEAEKITTGEDIGSVPKSNLSLKISQMENSGYKTMSSIHADKPSIPSQNECKMENSNQSFSLGVLRDNDSNPCATPKLESEYSDGKSRVSLLNVQQAAALCISPEADKKTTAESIGAIPKTNISLKISHTPNSVVTISSTSPQQSSEQNHSTVNLSHAETVPTRRIPELSESECLSEILQNTTNFEIMEAIGAENEKAPSSAAIADTQDIVLSKENAAEKREALAELPAEDQSTREWPQDQSHSNNINEKSSETVTELSSKYKSDLSEANCESTVLNPFMCWRRHISIRRICRRRWNHVWKKTAERWATWSDRSTVRFKKFRVNPHLKRAVIWEDADVQTYTPVYSETGTDSVLKELRSAAIGTAFNMGSWPNISLNESNINKMSVNVGRSTSFTQMNEVSLSDQGTETCDLPYFVNDKVTGNFMRTNLYEMSKGVSKDAFTQKIIMCHAETDVSFLPMCNGSSTGTITSTCNITYYKPCTGSEIKQLNENPIQESAHPVLRTLQSQAISARQINDKIDTQMTPGSSVEKMTTGISALRLELSEKTTSFANKDILILNEDNESVYEQKPELSSQTDEIERESVTETETQMTPGPSTVLVSTAVTPGPSTFQVHPTLNDSVKVSYAVQTASIHPMNLASRATKVTSTPIPLPASDTPSTETTCDKPNVACNVSFRRNCTCAPLNVATCEFLLNNLIKKALMGKTAHQLQLDGLEPTRPTMSEITELIGLCKTETGIQYIEDRIENDAILDGSEKSEDAPTLGPHKSASIMTSFCGQAQSIQVPAVSIYKVEAVSATEKPLFKTYSTLNADTENPESTEKPSSTENPASADNPASTENPASTEKPASITSRLSADADIQIDTNLKNLPSTEKPASTLNPAAASSNLSSDIQTNTDTNLTNLTLLQVSQKSIEFSQAMKPIFNNTLDQPMPSKIRCENENLTSTENLAATENPESTENPESTENPESTGNPASPSSHLSSDIQTNTDTNLLNLNTMRSGEKSVEFSQAVKPSFNNTLDQPKPSKILRENENVTPTENPASTENPASTENPASTENPASTENPASASSHLSSDIETNTDMNLMNLNSMRSGQKSVEFSQVVKPSFNNTSDKSVSSKIRREIDIKKQITSLSHLMGKKRQSSTISTPVLAQFSTPFCTDATADNWMNECHSTKKACQELTISDLEEVQKEKIAIGSPTITFSKDSLEDVLPINKFKHRSFSKNNDPEITVNPAMVDEVTSDKNILITKDVKESILQACPDICDADHSVGMLTSLCALRAERSQRKSSVPIGEVLSPKVYKALYETTKYVMSDSKKPNSGESNAVLKVDAEVEAVKVPDVRSAGVVTSSGRAFSLSERQSSCKDRSSHAHNHCALYRVTDSENPDKTHTHTKLVNMSEENKEGVDEYIKTHLVSSCRYYSGLLTKQLGRVKNNLTKHLALPVEEPEPTTRLPMYTTVEACTMKPSGRAALASQTLKHSHRTHYYKTPKHMSCCVLSPAISLTDICKHDKSNLKAVYYMLTAIEGRLRRLKLSTHNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUD0</accession>
    <name>A0A835GUD0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial dicarboxylate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_004115</name>
        <name evidence="10" type="ORF">HW555_000764</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUD0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9424055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9633401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32428" checksum="820EE354A32161BC" modified="2021-09-29" version="1">MSLQQELVLPKEVRVSKWYFGGFSSAGAACVTHPLDLLKVQMQTQKGKNISMFQLVGIVIRNEGIMGLYNGISASLLRQLTYSTARFGIYEMAKQQLTPKDGRPIPFYMSAFIAGLGGLAGGFVGNPADLVNVRMQNDMKLPPEQRRNYKNAVHGLWRVAATEGITRLWAGASMTCSRAALMTIGQLAFYDQIKIVLLSTSFFHDNVVTHVTSSLLAGGVATTMTQPVDVLKTRAMNAKPGEFRGILHLITSTAKEGPLAFFKGYIPAFVRLAPHTILTFVFLEQLRMNYGSIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUU1</accession>
    <name>A0A835GUU1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11843">
        <property type="entry name" value="SH3_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000014">
        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="305" mass="34187" checksum="86A6F2CC0C2FD850" modified="2021-09-29" version="1" fragment="single">VKKMAERVAKCREEVAKSREKYQSALAEITAYNPRYIEDMTGVFERCQQMEAQRLKFFKDVLFSFHKCLNISQEPSLPQIYEEFHHTINNADSQKDLKWWANNHGVNMAMAWPQFEEYTEEFRDIAKGKSKESLPTGPITLLNQRPVSEDELPPINNTNNKTSKAANHTDSAPAQTTVVNNTANSNNTIDKKSISAPIAVTNGTAAAPKSNKTSPAKDSTKGQENPFDEDEWDEESGGALTDTGEPGVPVRALYDYTGAESDELSFRQGDLFEKLEDEDEQGWCKGRKDGRVGLYPANYVEPVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GWT4</accession>
    <name>A0A835GWT4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GWT4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="407" mass="44860" checksum="39F5BB22790E6F5B" modified="2021-09-29" version="1">MLVPKTILTINFASSLGNGVFDPLTANSDSSDSYLENDIEAIPITTNSKIQKVPIKKEELFNKYQVKKVNIARNLIDYNKCVEINDRILCGYEKNKGLHELGQIIDLGNGCRIRGDRLECGYDSKNKLPKESQNLVMRQRPTRTPKSEISNKEHKINSDLMENILLKSALSKLLLKSEATENVAKPTVLIEPTKITNVTLNQIIYSTTEKVTFLTPKIAPKTEAVNQNTAAITQNNRTQSTESATESTESATESTESATESTELATDSTESATDSTESATQNTESAAQSTELLSESSKPILIKTIRKTSTTAQNTPAQVYDNLEVNDTPPESQIFKRAIPRTIITTETILILQNVATEPVPNLLTTVPSTTHKNSTESVNLQTPNSENATTACVENQERVVCYNFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXF5</accession>
    <name>A0A835KXF5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000553">
        <property type="protein sequence ID" value="KAF9406749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXF5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9406749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="229" mass="25301" checksum="2AD2FD2D479BC266" modified="2021-09-29" version="1">MDQAGGAGILSTPESVQLSVSLPGAAPPHLRLHAVCEAGARLLAAAARWLRAVPAAHALPFEVQVSLLKKCWPELFLVAHLQAVLRDRAATHAPDTSHDMAVPEISASDYSDERIAEVTSSLSRLQQFISHMEQLRLQQREHAHLRALCLFSPDGVPDFLTRKLQDYQIKVLRSLRATVQDEDRLATLLLQLPVLRTFSGPFLEDVFFVGFVGDVSIDDVIPYLLNAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXG9</accession>
    <name>A0A835KXG9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000867">
        <property type="protein sequence ID" value="KAF9404855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXG9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005117">
        <property type="entry name" value="PRK06549.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="OXALOACETATE DECARBOXYLASE BETA CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806:SF1">
        <property type="entry name" value="OXALOACETATE DECARBOXYLASE BETA CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="224" mass="23641" checksum="9B5B8C98CE71C807" modified="2021-09-29" version="1">MLRKFKIAIDGKDYLVEMEEINGVPQAIAPTQTSAPTAPTPVIEDVQASTAEPEAAAPNIVPAGNDAMTSPMPGTILKILVNVGDEVKENQPLLILEAMKMENEVVASANGKVTGLHVTLGQVAELFLNVQTLMIIAFGLVAFIMDSVGGVLFAKLLNLFRKEKINPMIGAAGISAFPMSSRVIQKMATDEDPQNFVLMYAVGANVSGQIASVIAGGLLLAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYQ9</accession>
    <name>A0A835KYQ9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000509">
        <property type="protein sequence ID" value="KAF9407073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYQ9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13190" checksum="3A403EB0E5829CE9" modified="2021-09-29" version="1">MQILRSTFVFAVRGYIELAPTVKADMVFLILLRRGGRGTFHVPYFEVYVFIVWPPLMFEDLWGSRKATRGQRLPTVSATALHYSMSARTSNKSDFIVEPSYCRFPDLCSVITFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYY0</accession>
    <name>A0A835KYY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_013151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000582">
        <property type="protein sequence ID" value="KAF9406508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="256"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="624"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9406508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="767" mass="86484" checksum="E4EFDF73CFAE80AB" modified="2021-09-29" version="1">MEEGDFDQRLRDLQREYLEFLDDEEDQGIYMEKVKQMIADKSQRLVVSVNDLRRKNPERARNLLDNAFEEQIAFQKALKEYVSSIDPTYAKIQEEFFVAFNGSFGNKHVTPRSLTSRYLGNLICVEGIVTRVSLVRPKDDEGNPLETEYGLSRYKDHQTLTVQEMPERAPAGQLPRSVDIICDDDLVDKCKPGDRVQIVGNYRCLPNKQGSFTAGTFRTILIANNVTQINKDMNMNITLEDVKLCKRLAKRGSTDMFELLSKSLAPSIHGHDYIKKAILCLLLGGMEKVLPNGTRLRGDINILLIGDPSVAKSQLLRYVLQTAPRAITTTGRGSSGVGLTAAVTTDPETGDRRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTIAKAGVHATLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDIADADHDNMISEHVLRMHRYRNPKEQDGEVLPMGSTVEMLSTENPDNDEAEETNASIYEKYDPLLHGNTRSKKEQYLNTKFMRKFIHISRLMKPKLTQEASDAIADEYARLRNQDMMDSDVARTQPVTARTLETLIRLSTAHAKCRLSSQITQDDAHAAIELVQFAYFKKVLTKEKRRKRRVSEDEGAASDGEQPAPPRAKKSRKTAGAQGEDPYTFSSDEEAEPVLRAARSSQPEPTQRTTRSSQKTIDTNRLTQFKSALHQLFKEERANSLPLSRVTSFVNEKYSHETFDDGEIMAALDKMTQDNQVMMADDIVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZC1</accession>
    <name>A0A835KZC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Wee1-like protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_012727</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000501">
        <property type="protein sequence ID" value="KAF9407151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000115">
        <property type="entry name" value="Wee1-like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017164">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF185">
        <property type="entry name" value="WEE1-LIKE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037281">
        <property type="entry name" value="Wee1-like_protein_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="208"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="214"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9407151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="565" mass="63109" checksum="595372C0809247DA" modified="2021-09-29" version="1">MTEWYRMKTGFINKHDSSELSTETSCEMSDSFNIFSDNLSPIPSSIVPRKLDFSSMDDDDGMRDAVPPPVSHSPPYKRVRALRLFDSPHTPKTLLEKCSTPSHHPPRSRLFPPKLNAQSGMPSGSSHHLHPPSGDDDSALGSLPPDELDESRMTRRAVANINPFTPDGQALNKKKRALSKTPTWGDATPEQPAKRLRESNISRYNVEFVELGVIGRGQFGRVTRCVNKLDGCVYALKRSLRPVAGSAAERAALTEVYAHAALGKHPHVVRYYSAWAEDDHMIIQNEYCDGGSLQQKMENGPLSEAELLLLLAHIADGLAYIHSLQLVHMDVKPGNIFICSGEGEPSHDSDDGYDDDEPQSHHKYKIGDLGHVTCVSSPSVEEGDCRYLPKEVLQEDLTQLTKADIFAFGLTLFEAGGGGPLPKNGQQWHDYRDGKLPELPKLSREFNQLLRKMVDPDPSLRPSAARLRRHPLLHPAGNKSKTQLRRELAAAKMKNELLARKLQEAARCIKSLTPNIVQNQESAKFRTRSAKRLQKPRVDTHIAEMIQSVTSPIRIDRTYRRTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZM0</accession>
    <name>A0A835KZM0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">28S ribosomal protein S34, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000378">
        <property type="protein sequence ID" value="KAF9408517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZM0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26977" checksum="12B1AB6BC48BA5D4" modified="2021-09-29" version="1">MASENVIIISLTYKCDRYANYSISINPKIKYIHFTLNIMASTVIKYVGRTTDFKGKTLWEIVGSLKNLGVGRIIVRSVFERYPEPSFMKIVKVETCPDEERRRVRIWVEKTFRGRKMPNLTEIYRTSYKPDYKLIPKNEEAKLLASVKEVHDYPEVILPRNIEMPPLMKKFIIKDHEKKGLEVMTDFTMPISYNYSPNRVKRIAKGDEKPTVKFSMGLGTPASPSLYEGVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZW1</accession>
    <name>A0A835KZW1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HF086_012788</name>
        <name evidence="13" type="ORF">HW555_013326</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000368">
        <property type="protein sequence ID" value="KAH9638835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZW1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="167"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9406207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9638835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="422" mass="48560" checksum="438D4E798A3C24CE" modified="2021-09-29" version="1">MSSSAIYILDVKGKVLISRNYRGDVDLGIIDKFMPLLMEKEEEGMLTPLLQTSECTFAYIKTNNLYIVSTTKKNANIALVFVFLYKIVEVMTEYFKELEEESIRDNFVVIYELLDELIDFGYPQTTDSKILQEYITQEGHKLEMQPRIPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANCNGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHAHSRVEYMIKAKSQFKRRSTANNVEIIIPVPADADSPKFKTTIGSVKYTPEQNAITWSIKSFPGGKEYLMRAHFGLPSVECEEVDGKPPIQVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0A1</accession>
    <name>A0A835L0A1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0A1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119025" checksum="B36FE0EDC7448352" modified="2021-09-29" version="1">MCLEYLRTCGAGRVTPGQVAGIMSKTQLPGGGPVLCRQRFKGVENFLRRIAFNLGNTPSQTEVKIISCIPIDVTDLQQKILNLEKQLDGMHSPQASESVACKASKSLKCNKLSSSKRTTVNTAIVDSKFPEVSTAAVSCKSLDCDQSTSPTGLHNRGKSNVSFVFPNEDPNACSQAFFYGNSELSQGVEEAINANFESYESAPKMVEEKQSCHRRFFFKKKKKTNKSKKGASPFVYYAQTNNSCPFTKSDQTEDPLKCESDVMTRSYLAQMINKQYKPKIIGNKLSTLSELSSPVCRDVQPHFDSACRCESDICSCCYGPFHNIDNHMNRLINPQTYMLNEIHLGNTYYDTNQYDIIPVKEKPVNLNAETARRKEQKPFFDTKRWPESSRFKNHHSPLYPIPVSNYYMPPYPAAYGVKDKFDTHGKKIPSNISRLEPILRKVIKRRKEIYKKERPPTIETTKSCSIDFGNIYSRKTSKKPKKQEVRQTLLPSKKNAECLTTNIITNSFNDTECQTAINITETNSIDAKTEQTLNQIKVILQSVLAEVKVTQTKNQVIRDKQKKDAVVQKGHSHNMIGSSLMNSVTYSPYNTMNPSAYMTTCSRHFNPSQLAGVLPNQFYYPHEGMKCFHNFPLFIQTPGVRPMCASCYRNSSHVKSGYMKHAATIATNTEEVKEEHTKETEKLIKEIYKSMALTMDFPNKDSSLSEYDEIIKPAHSLTTPVIVKTEPKKQTKRIKNAVQAVSELFMKKDMVETSDTLNITVESKVLSNEVTTQSQVVTTSDTEDRIQDDSFDRNIRTNSTLSGIPDDTHRKVIRETLVQNSDTIIETQTSSTDYDMESTTTLNALEPKQKKGKQGLFSKMLKSVKLFKVKEKPKQSSELSESEEECTSDSDDYQTVYSQKIEKSVNNRSRLQYLPKRKTHSKISYKQAFYRDRSPEKRRSPYMEQEYRRYWDERLMFQDARVLRSSERLYSDLSNVHAHHQTYEARSALMEPKSVSPKTERRTNRAAISDNKLKGTPKATAWLRTRKTGIHCGCGEQWKKMVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0I6</accession>
    <name>A0A835L0I6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000221">
        <property type="protein sequence ID" value="KAF9411536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0I6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032289675" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="278" mass="29848" checksum="F1E350055CFA1B32" modified="2021-09-29" version="1">MKVLIGLCILCVGINALGYHRSVGIPAAAEIRLRESMRVAGGLPSYLGEHPFLAGLVITLTSGYTSVCSGALISHTRVLTAAQCAWDGELKAQEITVVLGSITLFTGGKRQSASYTLHPQYNPTAAGFQRLQHDIAVLTTSYVSFSYYINTVPLPTGMNDTFVGRKSEVIGFGKTGEYNPIVNNQALRDIYVPVISNSKCNEYFWYLLSDAQLCTNGTGGRGPCGGDGGAPLILRYYSGSSDLLIGLVSFSHVKGCQSGNPSGYTRISSYMSWIETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1D7</accession>
    <name>A0A835L1D7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1D7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="799" mass="90337" checksum="40F2894CE233BAA6" modified="2021-09-29" version="1">MLINLMTFKDLIPTQETESYLQKTQNAITNLQAKLQSSRTNNFSSIPSALTSSLISEKTAISRLPISQLSRSNSLNYRLRRKDHSNDSSPLRSPGHYVITGSTKVPESTKILLNSASRSLDTDKRHDLNMNSPSSDRGLLSNSSDDKTLSNRPPYDVEAILSPHRKTHSRNRAFESQTHDVSNANPAVCLKTVLKNNALDSKYPRIEPTRCQGDKKCHQRVLSDGLKYKPNNIGFGSSIKRSSSFNTVNKNNNYIDPRITSRRSSGHSEEYKDYSDESDNGSYDKSQECRYKRQVISRGRIDSPDLKSVAPANSPRRCPNTPEMHRKFGPGLVRNSVRVTNKERLSPRVSEQPIVREERVKPTNHQSRRSAEPRQTTMARLTKSRSSTREVQPKHLDKGQKKPSQHRSSSALATKEIEFSNWKKRASYDPMKAAQEDKRRKQLAKRQDFNKDDLSSPSHSSPVHRSQSFHTNNIADLETLDYSSEETEDDQMLVTLPVDPMVTSTHSDILDLRPKDYSNLRRQAMTNDVVLSRDYVTSFQINQSSHDKKRREAREADKRKTFIIDDITPTKENIDFLTKTREDSATDKRKTFILDSDTNSTTNGSSPRNSSIFSHEKNSLTTGTSDTEGESGTESAPVVMRHQGGKRSAPVQAKQRYSGDYSMSSSTTSISQRKPTVQPRYLDISKYKNEQSPKNFLRRDPSKTYVGVLNNDKAVSKGSAQHYEMEQKKQELEKWKRRASYDPRKAAALGKSNKTPSKTASSVLRSQSFHGPVTAYTGLRPPPPDQICETYDASSDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1R0</accession>
    <name>A0A835L1R0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_008430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000164">
        <property type="protein sequence ID" value="KAF9413314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1R0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MHD1" evidence="4">
        <location>
            <begin position="265"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="5">
        <location>
            <begin position="514"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="698"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9413314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="876" mass="99474" checksum="7BC40AC15329B4F4" modified="2021-09-29" version="1">MLSVMYTCLHENLFHYLCEENNGAVTLPAARGDDAWKVYFNEIPEEIVDEFAMRYGIEAIYQAMTHFHCLSTKYLCAGVPAVMSTLLANINAYYAHTTASSAKEKFVKLLDQLHNSLRIDLSMYRNNFPASSAEKLMDLKSTVDLLTSITFFRMKVQELSSPPRASTVVKDCVKACLRSTYQFLFENCYELYNREFQVDPNEAKRDPADHGPQLESVDFWHKLIALIVSVIEEDRNSYAPVLNQFPQELNIGQLSAATMWSLFAVDMKYALEEHEQHRLCKSSAYMNLHFKVKWLHTNYVKDVPPYCGAVPEYPAWFEPFVMQWLNENDDVSLEYLNGAFNRDKKDGFQQSSEHALFSCSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMKRFAKTIVKVLVAYADIVKKEFPEHLKEERVACILMNNIQQLRVQLEKMFESMGGPKLERDAADILKDLQNRLNGTLDDLASMFANSLESRITASVKELGELLQKVGGGAAPGQQQPPVHHEADEVLRPLMDILDGSLTMYAESCEKTVLKRLLKELWKIVMKILEKTVVLPPMTDKTMMLKNLTNNAKNLAANAKIEDMTQLFKSTVGKQDVKHALSGVMDISKEHLSAEKSLTPKQCGVLDAALDTIKLYFHAGGNGLKKAFLEKSPELQSLRYALSLYTQTTDTLIRTFVSCQQNQDAAVVEEGSVGEVSLQVDLFTHPNTGEHKITVKVVAANDLKWVIQSGMFRPFIEVNLIGPHLAEKKRKFATKSKSNNWSPKFNETFHFMVSNTEQLDLFELHVCVRDYCFAREDRLVGVAIMRMTEIVEQGAIACWLPLGTRIKMDETGWTILRILSQRHNDEVAREFVKLKSEMRTEAPAGAPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1T5</accession>
    <name>A0A835L1T5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_014118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000862">
        <property type="protein sequence ID" value="KAF9404881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOC" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9404881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1388" mass="152989" checksum="E3EA1637FB17C9E3" modified="2021-09-29" version="1">MLPGSSEPSKRSRSLRGEISSTSSAASSPKRSQRRSNGNADEWWSPLRQRFGDNTDINAIQETDIEPEPLLVETRTSRVAQTGTQTSPDRSDSVCTTMQLYMGPSKLNQQDLPGRLSPKAVPRDRASSRARAYKRTSSPPPLPTRSAPAPPPPRKHALSPAQAECLRAVFAALLWHEGIVHDAIACAAFLKFHPQLPKQGARVVTRPAHDVTPARHQRHSVEVSNAGLYLRIHPTTLETLTRSGIEASTSRMRKVDFDTPIREEENLPGPSTEPAGSSRYVVNVLPPAMRALVALWDALYDADQLTSATDKLKKEEKNESDEGKSYSGIRKKREWNTRTGKTPYSVQCDLCGGSNVPPPLAAHMRTSHPGCKNPTTKGFDRTGTYQLTNPQPGQELPPTSYCGQMAQIYQLWYMFCEKCYEKAIKAAPSIRQGRSKRAEMVVFERLEQPVSIDHCTIKENAIFLLDLAPLTNPEPISMSAWADNSSRSPPTPPGSVWQPAPPFQCLPALGAAPKAFAASDAARYHSLGRPMPPAVAPLTSAFGGIEGNTSSNWPRVHRSVSMGQAGGRDLANAARPPLARAGSSLLSQPSAALRRLIGCGDWTAGASLSAFEAPRVDSDSLMNSPVMSFILSKRDLHAHRQKMDAAVRINTVRQYAFEAMNWLLRSATQPTCVHDVMWWFCNALDKFARIVPPPSLALDDNKENAVNESPRGVIPTASASAICPGARAARGARAAFHAFLGSVSALAPSLPPASAAGLQAVRCWALHYSPHDRTFLHRTMTEAGFVKAQSDNLPKIDAFMMTAYFASNPDFTSAEIRGVKAARSTRESYGDSAVGYVQVKRDGDICVVKARITPEHNVRQKCYAVICTCNETEETILSVQCEDCAAHLGGCKHAIAFLAWLHRRSEDPSTTSIECYWKKSKLSSIGTSKKFIKAKEMYKTPKHELVPTSLNTESFLTVVKNNCTLVGDTKNHLMKFYRAPSTVEKLSIHHLLSTSKATNPLDFIEYCKLIMTADACKGAAIATLEQNDCPLWHELRYGRITASKAYDAAHCNTLDGTLTETILGASKLRDTEAMERGRLLESQVLKEVEKICKIKISKCGLKLNSTHPIMGASPDGENSVYSIEIKCPTSEKAMGRYVSSGNKVTAKYMAQVQLQMHFSNKAKALFCVADKDFEKTKKISILEVNYDQQLCENLLEKCDIFWNKAIFPKLNISQVFSVISKILSHSEDGAYEEGLLGAIQESFHSYLNKENYVWTCPDVTGWCDISVSSRQGMAGALTDGSTETFWESGDEDRNKAKWIQMTYPGGTPDDRPHILCVHLDNTRDTVNKTLLVSFLYSGGSSEMFHMQDVEVDPKTATWLCYTMPTALYKRSPNNSMGFYLLRHKKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L205</accession>
    <name>A0A835L205_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_009249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000198">
        <property type="protein sequence ID" value="KAF9412176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L205"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14693">
        <property type="entry name" value="bZIP_CEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="251"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9412176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="342" mass="37695" checksum="A3EE41BE1626DA58" modified="2021-09-29" version="1">MLYPATSALPSGQPCVHCAGGAAPQLAPDRRRARTRALYAPHRHCFEVEPRATGAAGPVIGPGGGMESPQMYDAAAAPPPPPQPDLKKAVEDKRQPFPPPDLDELNGQEISLDLQHLIEDQFRSEESMALFQEILPGGKSPQPRYNRTTLAYMPQPVHSGASYAPVQTNQGHEQAPPIKEEPPEPHDYRRSVTCAQYTGQYNPQPTVGVSGPYGGGFTPLPPLGAPLLPPLLKHKPAPARRSSGKVLDKGTDEYRRRRERNNIAVRKSREKAKVRSREVEEKVKTLLREKEVLLKRLEAVSGELSLHKQMYVHLINLNHPEITELCRSMLQLGAPQAPDHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2T3</accession>
    <name>A0A835L2T3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">M-AAA protease-interacting protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2T3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32945" checksum="5D3F63465BEDC506" modified="2021-09-29" version="1">MMASSLFFLPRRICAKFVAKRVFVANFHSLYCLTKTIPATSQNSILTNSLNTSFYNQPLVEFRHLEPRRNDCGDDKYIQPGKGSLSFLKGFQRSFGFGRKIEKPKKNRKRRVPRLILLQNPFTWLMIKIDFSVLRNIWDPTFHEREFKFGTKQAISRITQVISSGQLKDLNGLLTKPARLSLMRELDRNWGEKQRSLLALNHDDIQISSPRKVYFIRIGDKKFCDVDMAFLALKWAPINSIEALIFTEIFARFHREYTPHCIPEWTIAYFKVTRFEVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2U6</accession>
    <name>A0A835L2U6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_010144</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000241">
        <property type="protein sequence ID" value="KAF9410902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2U6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="186"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9410902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="49510" checksum="94EE043131158029" modified="2021-09-29" version="1">MPGVCDEIIDDIEDLISSQDITPKERYASRKSVNVRSRKRDNKNDSEPAEKVILESVVPGTQTIYVKTWGCAHNNSDSEYMAGLLAANGYKLTEDKFAAQLWLLNSCTVKSPSEDHFKLCAAGSPRANYLTGLSVVGVQQIDRIVEIVEETLKGRLSRHTVRLFGQKKTGEGRKAGGASLLLPKVRKNPLIEIIPINTGCLNQCTYCKTKHARGELGSYPPEEIVERARQSFTEGVCEIWLTSEDTGTYGRDIGTSLPELLWKLVEVIPEGCRLRLGMTNPPYILEHLAEVAKIMHHPRVYKFLHVPVQSGSDQVLSDMKREYTRADFEKVVDFLREKVPGITIATDIICGFPGETEEDFEDTMKLCDKYRFPSLFINHATKFSMMGEPIDKPKMAGLTAPLKKGVVSGVTEVQTVKNGGKVPLPLPIIMLIVAVVFKLIWIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3W8</accession>
    <name>A0A835L3W8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_007143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000117">
        <property type="protein sequence ID" value="KAF9415109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3W8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000611">
        <property type="entry name" value="Capricious, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9415109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="442" mass="49753" checksum="9FC7C07BA5CA6A0A" modified="2021-09-29" version="1">MQFYADLQHLDLSQNHLVNIPTKSFAYQRKLQELHLNHNKLSSVTNTTFQGLNQLTVLNLKRNFLEELTNGVFTTLPRLEELNLGQNRISRIEPRAFAGLSALRILYLDDNQLSSVPTTSFSLLGSLAELHVGLNAFSFLPDDAFAGLNRLTVLDLNGAGLSNISENAFRGLPGLRSLNLFGNRLITVPTLQLSGLTRLEDLYIGQNEFISLESHSFKGLKNLKLLDITGATQLERIEKGAFEDNINLETIVLANNKKLATIEDCTLLGLPKLKHVSLRDNAIVTLSETVFIGKELKQLDLTDNPIFCDCQLLWLQQLLYDKSNFTQLHCASPEHLKDKPLRNLNADDLGCVLHDTRQQTIICIVVVACVATIATLVLILYRYRKSMQEKLKDYKWNKGRKNLEYHKPISTEEDCIVRGIHPSQYPAPPHTPGLRPIPVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L416</accession>
    <name>A0A835L416_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4 15">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_007807</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4 15"/>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L416"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000006">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054419">
        <property type="entry name" value="NSF_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21964">
        <property type="entry name" value="NSF_ATPase_lid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="17">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="248"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="531"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9414194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="772" mass="85492" checksum="2E3B4FB7BAD5B919" modified="2021-09-29" version="1" fragment="single">RMKAAKCPSDELAITNCALINPDDFNSDVKHIEVSTGPSQHFVFSIRFYSGVDRGTVGFSAPQRKWATLSIGQPIDVKPFKAQNADCLCSMTLEADFMLKKTTSMEPYDSEQMARDFLIQFSNQIFTVGQQLAFSFQEKKVLSLIVKNLEAVDVQALAAGANAVPRRVRMGRLLPDGAIQFDKAENSSLNLVGKAKGKQPRQSIINPDWDFGKMGIGGLDREFNAIFRRAFASRVFPPEVVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNAREPKIVNGPQILDKYVGESEANIRRLFADAEEEEKRCGPNSGLHIIIFDEIDAICKARGSVGGNTGVHDTVVNQLLSKIDGVDQLNNILVIGMTNRRDMIDEALMRPGRLEVQMEIGLPDEKGRVQILNIHTKRMKEYKKIAEDVDCKELAALTKNFSGAELEGLVRAAQSTAMNRLIKASSKVEVDPEAMEKLMVERGDFLHALENDIKPAFGTAAEALEHFLSRGIINWGSPVSSLLEDGQLYIQQARATEASGLVSVLLEGPPNSGKTALAAELAKLSDFPFVKVCSPEDMVGFTESSKCLQIRKYFDDAYRSSLSCILVDNIERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRQVLEDMEMLSAFTGVLHVPNLSQPEHVMSVLEESDAFSKKDLLKIQQDIRGARPSRLKQLRRFLSNAPQPTPEQIALSTANPRIFIGIKKLLALIDMVKQTDEEYRVLKFLTKMQEEGGLDLGTTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5N7</accession>
    <name>A0A835L5N7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(+)RNA virus helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5N7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027351">
        <property type="entry name" value="(+)RNA_virus_helicase_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01443">
        <property type="entry name" value="Viral_helicase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51657">
        <property type="entry name" value="PSRV_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(+)RNA virus helicase C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="828" mass="91814" checksum="BD904DBB37619087" modified="2021-09-29" version="1">MRGETLSYLRTPRDPTTTTTGGMSPATGPTTPSGSERAQQKAAAEKAAKEQAKTTSPENRAQQKSRLKAIGNFLNALLPSTSHNSSTTKQESALKRFFKKSREEPKKPAPVPTRADKGHVSPPTLAVNSGVTDHMKSAFLEYVAVVRATKEVHLMTCRKIMLTFQRGTEGLLGVLLKEAGAAVYDNATSQVIAGEMTGSVQRDERLRGPGSGRVGTHRTARFETPKGDSIVVTAKCTRIMLEDRILEMAQAISGTAEPPALQGGWAVPKIQWVNGVPGCGKTTWVVSHFNEEEDVVATTTTEAAKDLREKLAHRLGQRTRTRVRTMASILSNGFRAHDKCHRIIVDEALMNHFGAIVMAARLSGASEVVLVGDVNQLPFLDRENLFQLNYTRPNVVAAITHELSCTHRNPMDVAYTLGRYTLSRVHSLRVERYTGAKIPRLAQNTLFLVHTQEEKADLASQGYGSGEGSRLLTIHEAQGLTSDYVLVINTKTRRLQIHESVSHAVVAVSRHRVSCVYYTDDADDAAGRLIKKAMEANTKMVWKVDDSVTSSDHRAIRVVLGLRVPPRGGTRWTTRRFNTRKAEWGRFTEEMRSRMTTRGLNLERINNTNNKIELEGVAPHPASEPDVDYRCLEDISKSVDGVGAAYSYWRDGTEIRTKRMRLESMCTVFQAELLAIARATDLVVRGGFGEGAVHRWNERYTGGATAEVTRMFFPGVSRAYRVLGYLDRTSIWAQVLTGHGGFAAYLHKFKLKDSAACVCDPEVPETIQHLLLECPRHDRDRYDLEVSTGIKLNEITVAELMANKGSRPYLKRNCLKIAKIAIDRNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L656</accession>
    <name>A0A835L656_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L656"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="144" mass="16070" checksum="EC62C75C19F6A0E1" modified="2021-09-29" version="1">MEPGTGAACGWVARCNRARLAVRRVCPKYRRRRPALPATRCTLRRLTRQIYPSLDPRGQFLVGADVARVTEELPTSMKSAARGTGGLDPRVRAMTTSEASPVPILQYETILKWMVYPAAGDWSTSTEGFKRRVRDDTEDDAMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6Y3</accession>
    <name>A0A835L6Y3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_005670</name>
        <name evidence="2" type="ORF">HW555_003551</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000057">
        <property type="protein sequence ID" value="KAH9645125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6Y3"/>
    <dbReference type="OrthoDB" id="2354286at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9645125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="165" mass="18049" checksum="23C794E650DBB44A" modified="2021-09-29" version="1">MALVFDKCCFCIELRTGCLIIGYLNLIGNIIAILMSIIGLAAAGVVTAEGDKEDGTQAVGVLMLAIIGILLIFFILFLAFTIVLLVGLHKHKRGHIKAYLIYTVIFLVLYIILFFAGFGAAHINGGNVARDLISILLSIYFMLVIRSYYLKMDDPSNKPAVYNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7N5</accession>
    <name>A0A835L7N5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_011878</name>
        <name evidence="2" type="ORF">HW555_008587</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000170">
        <property type="protein sequence ID" value="KAF9413067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000714">
        <property type="protein sequence ID" value="KAH9632378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7N5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09510">
        <property type="entry name" value="SAM_aveugle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039144">
        <property type="entry name" value="Aveugle-like_SAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF0">
        <property type="entry name" value="PROTEIN AVEUGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9632378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="111" mass="13625" checksum="82EAFA3FB6034E90" modified="2021-09-29" version="1">MVEDSSLNSNKSKTKTTRPKAVYLWTEADVQKWLRRHCSDYYNLYWEKFHEHDITGRALVRINDNTLLRMGIMNKEHREAIWREILKLRLKADIVEIRDLERRHNYFNYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8V4</accession>
    <name>A0A835L8V4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_005400</name>
        <name evidence="3" type="ORF">HW555_003040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000895">
        <property type="protein sequence ID" value="KAH9628775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8V4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9628775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="319" mass="36225" checksum="E217BC906CF45F07" modified="2021-09-29" version="1">MSASTFKRLSKIARSTWACTNCLSKKDLESNKIATTDDDSDESEEKADDIRKIIRQEIRTTMRAEVKIIVSELRKEIDDLRKQLDELKLSKQTVATFSRDISDLKTSMQFHADEQADIKKCINDISLEGSKQSSLVIDNLVAKIDSMEQQARNCNAEICNVPEKRGENLLNIIEMVGSAVRFPICQKDIVSIHRVQHATQQGNKPKNIVVKFASRILRDNLISAYRLTKTLKAEQIGLPGSSATIYINEHLTLKNKQLFRKTREVAASHNYKYVWIKNSTILVRKMDGTSTFAIRTEDDVRKIKGKDDNIVSYSASENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8Y5</accession>
    <name>A0A835L8Y5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8Y5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032134">
        <property type="entry name" value="DUF4816"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16086">
        <property type="entry name" value="DUF4816"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033033900" evidence="2">
        <location>
            <begin position="23"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="49300" checksum="A7D4009FE63A29EC" modified="2021-09-29" version="1">MRGTWSQVITLAVILQIALVSGKALIPQNQQAQQQVEQKQHTAQKRVGYDYPAPSVDLVNPFQDHDDLHPHDDHHEVIDDHGDHDHHEHHEHHDFDDHDHHEHHAIHEEHHVEEHHEEHHDHHEHHHPDPGYWKKKLIWKPGWKKIWKPAKKQIWNPSWKKIWKPVWKPIKRPVWKEIKVPDWKKIYKPEWKPIKVPAWKEVKVPDWKKITVPVYKDIVVPGWKEIQVPAWKKVWIPEWVKVGIPGEKYLGKDHEDKKLVWKDEWKQIWKTEKKQIWVDDKKLVWKEAWQQIWKPSKKLIWVPDKKLEWKEAWKQIWVPGWKEIWVPGVKKIWRPVWISEWFPSPDHHEHHHESHGWDRSDITDNNTAGSQKTLSVQPAPQQQGAQKQAQPQQKEAPKQTIKSWLFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9C7</accession>
    <name>A0A835L9C7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_000938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9C7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010596">
        <property type="entry name" value="Methuselah_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06652">
        <property type="entry name" value="Methuselah_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032862321" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="473"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="731"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9423880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="781" mass="91059" checksum="E31EF48052735E81" modified="2021-09-29" version="1">MWALLTLFTVIGRVVTQSEPCDYNSSVKLDNRTYNGIVFNEEELFYDNITNTERGCICMKKICVRKCCDPGFIYNATHKVYTCQQEKQNEEFNQHLIVHEGFNVISKDKFDPMKKFHFIYGRMDCTQFNNSVRIGLKKKNLPRLLTALSRNEMQTIIVFIVFAIITQIVSQCDEEYSVVLKNRTYKGVKYERNEIIVDNVTKVERGCVCLKEVCAKKCCPLGQAYHRQQKICIDITEPFYPPVYREYKLLPGYNATKELHFFYGKMNCSDELEEVRVPVAPASYDFHLRTVRIITYCRLMISWYFYAGILPIDTLINGAYFGRKLNENETFITKNGEKRGCVCLNGRKCIRKCCHFGMAYNFKMKKCVDLPTGKYSNPLVTFEDESIRDNYVILTGKMTCSKRKNELRLRDGKLYVKIETSVKALVYDASKYCIDTFVSDTEGPHLNALICFVSNPERNNYTMSTVYAWLPELRNLHGMVLMAYLLSFFVGFLFLATMQILILLKEISEDICIVLTFIVYFSLLSAFFWLNVMCYDIWWTFSGKRAHGRSGSQNKRFLCYAIYAFGVPTILTIVLAALEFSNIPLHPLLPKLRLQGCFLYGNSKLLYLYGPIVILCVANLIFFTLTAFKIAKIKRETKMLRDKESSTHDQDRKDTQRFTLYVKLFTVMGINWILEVVSSFYPEADVFWQFSDAYNVLVGLIIFIIFVCKKKTWRMIKKRIKDYQRFKSNKKRRDSREVNINNRQLTQWRTQPDRTSSLETIKTTDGETSLRSNKSISTNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9E0</accession>
    <name>A0A835L9E0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032485359" description="Fibrillar collagen NC1 domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="6">
        <location>
            <begin position="1246"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="853"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="966"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1684" mass="168776" checksum="82B068C16BD68A9C" modified="2021-09-29" version="1">MRWMKAACWALLVLPAACKELSEVPIREEIIQELPQAQDPDLINYDDYNPTFEEDENAIIGDRFREPSSTAPKCVDIGRTWNEGENWKRDNCTLCQCHAGRVNCSTIPACLTAVPTRPVLIGAAAQPTTPVRGPVGLQGDDGPPGPPGMPGVNGIPGAPGLPGPVGQMPDVNAYLAQLAASAGGDKGPPFDPYQYMQASVGTPGVRGIPGPQGPPGPQGFQGPRGEPGEPGLPGQQGPPGERGPQGLPGKDGSPGDDGEPGPAGAIGQTGPRGLPGVPGIQGLKGHRGFDGKDGAKGEQGLPGEKGPTGMPGPMGPAGPAGPVGARGERGREGPPGPPGVRGVDGAPGPQGLMGNVGKPGSPGFPGAPGLKGEQGVSGPKGSQGMQGPRGEAGRPGQPGEVGTPGIPGRDGIPGEKGVQGQPGASGPQGFPGPRGLPGVAGDAGLPGSKGMPGQPGERGQKGDSGIRGEPGAPGPRGLPGNIGPEGKRGKRGLRGPAGNVGPQGERGLQGMRGLPGADGPMGAKGQPGERGGVGLPGSKGSTGDPGRPGPQGLQGPRGTIGRPGMPGKTGPQGERGIPGADGRPGEQGSQGIQGPPGLMGGPGERGLQGEPGKDGEPGQAGPQGPKGDAGRDGGPGIQGPQGAAGPPGERGPTGPAGPTGFPGMPGAAGLPGSPGKEGEPGMAGPAGPPGPSGPRGERGFTGDRGQPGQPGSPGEKGENGAQGPDGPPGPEGLRGSKGHPGSPGAMGLPGQRGLTGAPGEKGERGAAGPPGNDGQPGRQGEQGPQGPMGSVGPAGEPGERGEPGVPGTPGELGAPGSPGERGQPGPQGAPGLSGPPGLTGMPGLKGERGYAGAKGQQGSPGSPGVPGEAGPRGLPGLAGAKGARGDHGPKGETGHGPQGSTGPAGAPGIPGAKGATGDTGRPGPPGPVGLTGPQGAEGPKGERGSDGEPGMQGPIGSPGAAGERGPIGLPGVIGPVGPQGLRGAQGESGAPGKPGADGAPGTPGTPGLQGPPGPMGEPGPEGRPGKQGQPGISGRPGDKGPIGPPGAAGPAGPPGLQGPPGPSGPSGPTGERGPRGESGPPGVDGPQGPPGKVGPAGLDGTKGERGEPGIDGAKGHAGLPGLPGMMGAPGRTGERGLPGPMGPPGKDGEVGPRGTPGRDGNPGPQGPQGLPGGRGPQGEAGRHGAPGPAGPPGPPGPPGEGLAYDAAAIAAMLQQGSVKGPDPLGDDPNLLPPRFFKEDMTPAERKEVVMKAYERLKVSLDKFLKPDGSKEAPAKTCGDIKYHHPEFESGQYWIDPNGGDINDAIVVHCDMETGSSCVFPKPMQSQDITYDGKEHEPWLSEMDDGFTESVTRRMNEMEAQIQSAGQAKDTVAKVAEEFRSFRELIFKILGLLRSQINECSRRIDDMETRHRRKALVFQGLVETEKEDCRKLICNVINSKMSLNISESVITVCHRLGVGHKDHHRPILVRFSSLDLKASVWRAKAGLRGSTYSVKEFLTKTRQTLFTKARQHFGMRSCWTQDGIINVKASDGSRHRVTSIEALDSLLLKFPRAPGNKSDHKPSVTYKADHTQLTYLQLMSTKAVQNVTFHCRNTIGYYDPTANNYRRGIKLLAYNDAEILPKANNRLRYKAVLDECQHKSSNWARTIVEYQTDKPARLPLLDVAVRDVGRPQQMFRVELGLACFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA27</accession>
    <name>A0A835LA27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEHE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035035">
        <property type="term" value="F:histone acetyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026180">
        <property type="entry name" value="NSL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443:SF18">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="2">
        <location>
            <begin position="640"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="751" mass="83112" checksum="DA432D4EE8CB9E16" modified="2021-09-29" version="1">MWVRKQPLLYYNLQAQDLTSMFTVSEKRAESLTARQEARPDAASAPASAAGEVQVMAPALSIASREPHIHDSNLFGEIERPLSQRRRALASVDNLAPHMDEDDMGPQNQPSLAKDSQEMEQILVDLGNSDLDQQGDLLQAIKTLETGGDTLSGGEALSTDDPEAIFPLSGFELAEPADSEGDAMEEKIKVMQLRLERRCSFLQRRLRILQARAIGKKVSEEAAQTFEKCTRGVRKDSGGGRPVGLKTFLKTIETTSALQASAASRTVVGPKYYNPGTSKGDASKSASIGIPSGTLTGLEDTAGALRSHLSVVKHELDSDATLSSSGAESNDEAVTYNNPHQQQMPIEKRALWSWQRARASIASRWCWLQAQVQELEYRIRQHNELHKQVREAKGPVEFEGEPVAYEGSLPGSELPDDDPSHETCARVRPLRRETFKKRKLLQMHNLHIATQKAARPSDIKCTCEQGLESCAVCTGRAEPTQPAPPFSTVPPRLRIAAVDPGFHPVLSDIKDMSPSLHMSALTSRAWFRPRAGRAWRGAPPPQQSQAASSSGRAASSNTHTPKPLKRHPTRLKRGRPPLTKKVKERDRDEDTPTSGHERSRGRSSTESRSWRRQSYDIDNIVIPQSVAANTRPQILTYKEIITPKWRVLEIPEAPLNNGVVKTNRQMSIESEEEDVSEAAVSLRHRRAESRERARYVRKRRARRDQPEPADAADATDAMDPPRPHESPPATPVHDPPPPPRQPTPPHHEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBP5</accession>
    <name>A0A835LBP5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBP5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="83" mass="8547" checksum="435C6ABBE2B98F4B" modified="2021-09-29" version="1" fragment="single">MARNKPADGGGHVNQKNAAGQKSTTPCQKGGPKTPVKPSAQKGAAKTAPPKQAAAAAAVKTPQGKKKKGHKHQQYELIVTINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFE9</accession>
    <name>A0A835LFE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="364"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="735" mass="83234" checksum="299A16D4C8E8AB0B" modified="2021-09-29" version="1">MDLSSYKKPKRKSIQHSDPGKILDLIMSLTDETCNEIQIKINTYLEEECDADLVVPVIVHRERKEAYIEVVGTTALPRERKIHLTQKLTDALKSKTEQTDLLTNFGEDFQSIVSPHLPKDNTKKRLVLFSVTDCPFSVIFCVVSPKAEESSVPITIYECGVYVWPTLKKAIALEYEKALKIKCQQLLRVAKRLFAQVASLETLMQIAMDQAKQLTKAEHCTVMLIDIDNMELYESCSTCKDSRGRRCPLGMGIAGEVIKTGLLINSRVPKENPAYNPAIDGLPNKECRSLLCFPIREQSGIIGVVQLINKTSDPYFDSMDEEMVLAFSIYCGVCIMHSVVYQKIEEAHIRNALANELVMYHMKVTDAEVSRMMTCNGFHQHPHISNLHFNPRALPLRELPCYAVKMFTDLGLHVRFNIKPQKLSRFILYVKKGYRDVPYHNWTHSFNVGQWAYSALVNYKLISRGYLTDLQALMYMIAAFVHDIDHRGTTNSFQIHGETTLAALYSSEGSVMERHHLAQAMCILNTEGCDILAALPRRDYDRAIMMLRDNILATDLANYFKNYDDYRVVSMDYQKPNRLHCSALQCLLMNAADLSDQLKDWGCVKKTAAAVLTEFFKQGDLEKVRGDLPGIGMDREQCFIPDLEIQFLQNICLPLYDMVGKIIPKAAPCTKIIENHIERWEASKSVFLEVPLTAGLSVLLSPELDTLIDLNLKEAAKPELAEGENNAPDPNAKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K1DCZ6</accession>
    <name>A0A0K1DCZ6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemosensory protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CSP16</name>
        <name evidence="3" type="ORF">HW555_000173</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>Putative chemosensory protein genes from Spodoptera exigua.</title>
            <authorList>
                <person name="Liu N.-Y."/>
                <person name="Dong S.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KP729033">
        <property type="protein sequence ID" value="AKT26491.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K1DCZ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036294015" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKT26491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13530" checksum="BF652396BE56DC06" modified="2015-11-11" version="1">MNALLIAVFALAAPLVLGYDEKYDKLDVDKILGDDALFTAYIDCMLDKGPCSVEHSADFRQLLPEVISTACAKCSAIQRQNVRKTVKALSEKKPDDFAQFRTKFDPKGEYEKAFSAFVIGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1X2</accession>
    <name>A0A835G1X2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000604">
        <property type="protein sequence ID" value="KAF9406360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1X2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30906" checksum="3F4D6037DE098936" modified="2021-09-29" version="1">MVKCAACGKFLSAKGGATCGNFACHNRYHLACLPDAAPTGSDWLCPECRSRLPKGDNSATPVRGLGPVTAAAVVATPDQGAANKSPVRVTHTQNALSKFTDSKEVPRTGSDPASDGEPSPDTQLSLRDEIRLFRSELREVRDEMREFRREMAGLHSTVGICTERVDHLEARVEALESKQSVAMPDGKVSQLENLVSQLRLELNDREQDLFSSDLEIANIPEIPGENIVHTVGLVAAKLGLTVEERDIVFAQRVGQRVEREGVRLAQRAQRQRQRRVAGASWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2I0</accession>
    <name>A0A835G2I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uncharacterized sensor-like histidine kinase ycf26</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_014328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000979">
        <property type="protein sequence ID" value="KAF9404454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2I0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000001">
        <property type="entry name" value="Two-component sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.500">
        <property type="entry name" value="HAMP domain in histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050351">
        <property type="entry name" value="BphY/WalK/GraS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057640">
        <property type="entry name" value="Cache_WalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049814">
        <property type="entry name" value="Resp_reg_WalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033092">
        <property type="entry name" value="HK_WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45453">
        <property type="entry name" value="PHOSPHATE REGULON SENSOR PROTEIN PHOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45453:SF1">
        <property type="entry name" value="PHOSPHATE REGULON SENSOR PROTEIN PHOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23846">
        <property type="entry name" value="Cache_WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="201"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="258"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="383"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9404454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="610" mass="69489" checksum="7F7A42A99ADA976B" modified="2021-09-29" version="1">MKKKVHFFQSVNFKIALSFILLLLIAIEIIGGYFIRELESTTINDFKKNVDLQVTQLANTLSPKLGEKDQDRTEIDANLKKALNDFSASETIEARVVDDKGIVRATSDLNQQGIVGKKNDYRDLNDFSAKKYAAMDKDQRVYINVQPIQSPNAGESVIGVLYVKSNIEGKYQEITDTARIFFTASLIAGAISIIVTLLIARSITQPIGEMREQALRIARGDYSGKVKVYGKDELGQLAETFNQLSERIEEAQETMEAERNRLDSVLTHMTDGVIATDRRGKVITINEMAISLLNVKNAEVIGSSLLELLDIETDYTLRKLLEDPEEILIDRSSSSIEEDQMIIRVDFAMIRRESGFITGLVCVLHDVTEQEKNERERREFVSNVSHELRTPLTSMRSYIEALSEGAWQNPDIAPNFLNVTLEETDRMIRMINDLLNLSRMDSGNGELQLEYVNFNELINFVLDRFDMMVETRDKKYTIQREFTKRDLWVELDTDKIIQVLDNILNNAIKYSPDGGLITCRLLETHNNVIFSVTDEGLGIPKKDINKVFDRFYRVDKARAREQGGTGLGLAISREVIKAHNGAIWVESQEGRGSTFYISLPYEPYEEDWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G441</accession>
    <name>A0A835G441_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ectonucleoside triphosphate diphosphohydrolase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000558">
        <property type="protein sequence ID" value="KAF9406704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G441"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24046">
        <property type="entry name" value="ASKHA_NBD_NTPDase5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50168" checksum="1B94D6F38CC12426" modified="2021-09-29" version="1">MQIRQRKLKDDTSAPHINVRSRNIKHPRKLKKFFIFLIVLALCITYFLGLFANQSQWLDGIAKSLGYESVYHHAVIIDAGSSGSRVLAYKFRVPFTVFGPGNLDLVDEYFEQSKPGLSSYADDPAKGADTIVQLIKKAEFLTPPEKRKTTPLIVRATAGLRLLPADKAQQLIDHVARAIAELGYDVGSDGVQIMDGSDEGIFIWYTINLLHNLIGGSTMAALDLGGGSTQITYQLSNSETANFPKKDQFVVPAGDNITLYTHSYLKLGLLAARFGVFQSEALKDETQEFRSVCVDPIIQREQWTYANKNYFVSGAFRVHGSKRSAVYAACHAVVRRSVMAAVDWEPKKAPLGSVAAMSYFYDVAADAGIIDVMTGGQVSVSAYRKAALEACSTPNVDQPWACIDLVYIVTLLQDVYKISDDEPIYLFKKVNGHEVSWALGLAYTTIMNRIVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4S2</accession>
    <name>A0A835G4S2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000373">
        <property type="protein sequence ID" value="KAF9408601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4S2"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="241" mass="27308" checksum="8608A4B717540526" modified="2021-09-29" version="1">MSFDLANSGQEREDRKYYDRNKGDELQISRTDMNMLIMNYLVTEGFKEAAIKFQQEAGLQEPALCSSLDERIMIREAVQTGRIPDAIAMVNALHPELLDNDRYLYFHLQQLQLLELIRAGRAEEALAFASATLAEAGANDPNALTELERSLALLAFPDPHASPFADLLLPSHSQKIASELNAAILKMENQEYTNPKLCSLLRMILWSQSELDKHNIKYPKMTDLANATIDKPKMYGGFRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4X8</accession>
    <name>A0A835G4X8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000695">
        <property type="protein sequence ID" value="KAF9405706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4X8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="180" mass="19193" checksum="43C79D740342C3C6" modified="2021-09-29" version="1">MNAGQILFHNVRQPQRWYCPSASSMKNSGIPPKSSITQLYSYELIIKTGNSKASVVARISHDKILHTLTAAILIADVREPPDIAQVYREPHHSQQELRLLGPGLTLPRRITYDLFLILVKVLTLLVVAGGSGGGAVGAGGASEGGISDGSHSPLRRSGPGLSPCKIRLNLGVAAGPWLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6T0</accession>
    <name>A0A835G6T0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000352">
        <property type="protein sequence ID" value="KAF9408933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6T0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997:SF2">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="196" mass="22303" checksum="FE4D82E599921055" modified="2021-09-29" version="1">MSCFNSLVDMEVLQQEIENAKPTGEVDEVFKKYCAKTPQFKNCFRNMTEMVKPCFSPAEQKNFNVMYNVTEQLADFICFKEGDRIALFIAEGGKECFQDQQDGIQECFSTVFDNKTQANIQNISVSGIMELEFKEKQCDQMTGLQKCMVSTLEKCPKPTSANILDSLFNFIRKATPCKQFIKAPEKSQARGRNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8A4</accession>
    <name>A0A835G8A4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000356">
        <property type="protein sequence ID" value="KAF9408878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1433" mass="162327" checksum="983E80B6EAB04B30" modified="2021-09-29" version="1">MMITILGFPPKTKYQDVKILIKQECNINDFILDNLVNDSAAVGTKKVRVGLTDNSEGYKVMKCLDGYQMPGNYVLKAIPVGKAATTLPPQGAFDTHIGYQDHSRNDYNTAPRNDYVGHSNNYNSQNPHGSGMHGSAPHVGRPTQGPGGHSGPMDVNRPSPWASGTTSNQWGAGPPMASQVPQNTFGGFSSPQGNINNPYGQQHHQNPVQSRSDVRPGFNQPRTHTEQTYGGYPPKANIPEVPPRQEVRHALRSIETVDTGSVSRAPMHGRYPSQSYQQEKSVTIMKDNFQGPTQYNISNPGAQTSSSGQQYPMSAPSASPWQSQEYEKRHGHSPRREVISHGGRSVERRPSPSGRRVSPPARRISPHARKFSPTGKRPSPGRRDSPHKRPSPMRRLVSPSRRTSPGRRPTLGRRDSPQRMNRYSPDRHHSDKLDKFGPDKLKQVRPAYEPTSHASNQDMYSGGYRSDARESVQYPMQGGRQGQRISPWQRDEPVAMKKQDDERRDITRMQMSRDRIPDVAVDPKHSITPQRKSRSPRSSPEIRDAPPPPSWPGQKGREPDSFTRTTRTFLRESKPRVPNMFQYGSDHSEKTKMCENDILTTASEDHSSKIKFDPPRRCQRENQYRTPVTVSASYKGNRNSLHEMILKQTAVMLIVGESLQLNVNLTFKGKITNNLEDRGSMRNACTQMNTIAVESRHLAMILEKLMLLIQISIKILKTSTRELCSSKRKQKNCVGWVLRKGMIMRRMKQGATTVKENAKRDLSGTGGETTPRDDRPRDDRPRDDRPRDDRPRDDRPRDDRPRDDRPRDDRPRDDRMREDRSRDDRPRDDRPRYDTRPDDMRRPEFRPREEYSKQPEREQDRRFTVNPAIRMKRDKAIEEICTKLLDRHEHYRPAKEEHRARVMEELQLAIARIVFDMFGDNDVSFIEIIIKFQAKYTYKDEEKLLLDVMSSLPSHYRVAKRQAPESTEVPAKTARPDPSPNLKSEKRPVLSPKKQRPLQTVLKRKPEQLPKLEQKPSSSEPKVARVPAKNVPETSTTSAKKLDVKKVEEEKKPATLPTPVETPVQSAGHYELNDRMTNMVETELRNIMIKVWQELPDNPMDEAEALVVDKLRNAAGDDLRNVLGLNITKRLLNVHNPLYVKVQFSGKPEKQQLGDFLKRYNFIAFKRIEKTVNMFAAQVKTISDFDRICSDKDVRCGGVKVTINPIYKFTKCPPNLISSFYNEDDNAGDEAEVNEKDDKSEVKTDKGKPTQSIASDPSKLNINKDENNENITKVDKTDNKTDGNSATSKPVATKVLNEKPAVNKADSENPAENKAANEKSVINKADSEKSTQKTVTKVPVENKPSVNNDKVANKPTVVNTPAEKKQTVENKTANKTVPPVKNVAKPVEITNKVAKKHKTSNVESDNDELDDHDIFALLSEGIVLDECSGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8D4</accession>
    <name>A0A835G8D4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000275">
        <property type="protein sequence ID" value="KAF9410163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8D4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="27716" checksum="078EE3D33DF0E824" modified="2021-09-29" version="1">MERVFKFALNGQSQQPEPSTSTGSGTSRPRRGRPSGANRVPLTLEERRARNAQYERERREDFAAAQTELAEAAGCDPNASTINLMAFVVTKLKNASEDFSIEEYQRINANLEAQIASCFERLGPEYVLSGDEDDVEADDSNTRKRKLSLETSRDEKRMRPGTEEVPASESGTMVSTTDLTEAGPSFPGTHSQWPSSFFQTELPTPSQFTHQTPSPLLQLETALEQEIALRFSQDDLLQIYGALESEDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8P5</accession>
    <name>A0A835G8P5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endophilin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000215">
        <property type="protein sequence ID" value="KAF9411722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8P5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11790">
        <property type="entry name" value="SH3_Amphiphysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000172">
        <property type="entry name" value="Amphiphysin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF3">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="12"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="403"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9411722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52645" checksum="D6BED99619B38093" modified="2021-09-29" version="1">MSRSTDDASGILLQNLGKVDRTLDDIFEEHLQNFNRQHQQATRLQKEFNNYIRCIRAVQTASKSLMEAITEVYESGWSGHDLLYVQAQNLEMLWQDFSHKLGDQVLIPLNTYTNQFPEVRKKIEKRGRKLVDYDSQRHSFQNLQSNATKRRDDVKVTKGREQLEEAKRTYEVLNSELHDELPALYDSRVLFYVNNLQTLFSAEQLFHSESHKVFGELEAITDKLANDCQRGSYSKKSNNVTMNNVAPPASPPALGTLNGKHTDTVQTPPSPAMNGSSPPPSPAEGDTPAAEVRAPPLPEPRSEESSKEKAPTPPAKREDKSPTPPVTNNNVEKEPADKKVEELYDIPVGSPVPPEKSNNNSEEKRQVDVEPKGEKGKENDSENKNDDVYDIPIGATLAGLPAGTLYRVRATYRYTREDSDELSFDVGEVIRVVEYDDPDEQEEGWLMGIKESTNEKGMFPANFTRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G949</accession>
    <name>A0A835G949_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000337">
        <property type="protein sequence ID" value="KAF9409122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G949"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="82" mass="9437" checksum="30C6AC8400E1638E" modified="2021-09-29" version="1" fragment="single">NRQNHEPTCAYSSKFGLTNYFSVCEINFQICILGVKKETTDKQNHYNYGEIYYNGLPHPCGFYQSHTTNGKEAIDLYYNLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9J9</accession>
    <name>A0A835G9J9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein C10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0456 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000199">
        <property type="protein sequence ID" value="KAF9412143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9J9"/>
    <dbReference type="OrthoDB" id="75738at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026317">
        <property type="entry name" value="P_C10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463:SF3">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14974">
        <property type="entry name" value="P_C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="116" mass="13013" checksum="786DC2B22DAB5994" modified="2021-09-29" version="1">MASPQNVTVDQVRLILTEVIDALESPDYASKLDEAKEAAGNEMLKMMQIVFPMVVQIEMETIKRHGFPNSREGIVQFTQLVREMEALDGEVARLHTQIRSHYLPPVSISSTVDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9N2</accession>
    <name>A0A835G9N2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005746</name>
        <name evidence="1" type="ORF">HW555_010018</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9N2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="22078" checksum="B17AAFFA576799DB" modified="2021-09-29" version="1">MRLPEWNPTKFKLDYEKAAINAIIKVFPTVIIKGCYYHYNKAKRKKPEYDLTNVTRFEGVSAILPLLSENEIINGWDYIIARYGDSEGTGTKKFINYMEKQWLREEYLKVWCVFGDAHRTTNALESWHNKLNKTIGTKHPNIMHFLHTIEEDSSQNTVRNQNNKANRQKENGLDMLWRFYDTRIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9U8</accession>
    <name>A0A835G9U8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000317">
        <property type="protein sequence ID" value="KAF9409463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="162"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="312" mass="36188" checksum="11AF6E9C4A9E721E" modified="2021-09-29" version="1">MEEIKPCPILEFNENQLTEVRKVVGYEDVDKLKQDLDIFEDWISKQPHFVLKQFDRGFLERYLIYCKGSIERAKQRFDKLCTYTNQMPEFLQNFDIRNEFVHLLNISQTCILPKPSADNYRVVLTTLTGADDDEFQLISYYRYLIVLVQYMMHHDYCVGYELVGDCTNFTLGTVKKMNPVIIHKALTMIVDALGQRMKKLHLISGSKFFDTIVLIFKQALSAKLAQRLVIHNNLESLYEHIPKQHLPKDLGGGLKTMNELSERTFKEVCTDEHLAVVKRMETATTDESCRPTAKFNEEYSGTPGSFKTLCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAB3</accession>
    <name>A0A835GAB3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3 10">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_010227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3 10"/>
    <dbReference type="EMBL" id="JACKWZ010000245">
        <property type="protein sequence ID" value="KAF9410802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAB3"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9410802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="587" mass="65590" checksum="9F3A5B5E8C925D3C" modified="2021-09-29" version="1">MISAITNQSTVPIGDAVIATKDTCIGFEICEELWNPQSRHIPLGLDGVEIIANGSGSYMELRKAYVTVDLVKSATFKSGGAYLFSNLRGCDGQRIYFNGCSCVAVNGEIVSRGMQFALHDVEVVTATIDLEDIRSYRTQIRSRSHLAASNPPFPRITVDFALSDDEDVYLTTSPPIQWQYLTPEEEIELGPACWLWDYLRRSGQGGFFLPLSGGVDSTSTACIVFSMCTQICDAIQKGESQVLYDVRKILCQSDYTPSDPMELCNRLLVTCYMASENSSQETKQRASQLASEIGSYHFPIVIDAAVSAVIGIFTTATGFVPKFRTKGGCPRQNLALQNIQARLRMVLSYLFAQLMLWVRGRPGGLLVLGSSNVDEALRGYMTKYDCSSADVNPIGGISKTDLKSFLQYAKNRFFLPSLSEILQAPPTAELEPLTDGQITQTDEQDMGMTYAELSEFGRLRKTQHCGPYSMFHKLVHTWSDKCTPQEVAEKVKHFFRCYAINRHKMTVLTPSYHAETYSPDDNRFDHRPFLYRVHWNWQFKAIDDAVAQMSKDKRGSSDRPQDVKISSASTSNVNSHFMRGDRKGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAM3</accession>
    <name>A0A835GAM3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_008575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAM3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35503" checksum="1653F1288277F4C5" modified="2021-09-29" version="1">MNKFIDTERLITEVRLREPLWNISHVLYKDRDAKLKAWQEVCEALFPNFDEMTLTEQKDIARDAYTRSKAAIINTKSGSGGGAIKKKYIYYDHMRFLDKKHTVQVEDSLMADDSQTNISVPDFEPEPEPQPEPQPSTSTIFDTRVFEQKNTEPASQTSQNKKNRRITKSKRSINKEEFEFDKQMLQMFIENSTILQNDDMAFFTSLLPITNSFSISQKLTFRSEVLKIATKIHDGDNALSRPQSQSSSTTYFVTSPESYSSHSQTSNNITAQESEQLLTNIYPNMLPVMVSNSNVEQTDFSDLVVFKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAR9</accession>
    <name>A0A835GAR9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000172">
        <property type="protein sequence ID" value="KAF9413009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAR9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9413009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="15539" checksum="7A227D0B479364E8" modified="2021-09-29" version="1" fragment="single">TLSLLGLCGGLVQIGRECARQCCPHVSGERRGVGRGGGRGGGPALRAARHFVVDSFSAIVEVVSARRPQESVWVYAMGLRALQQLLHHLLENVVGKVTTVECVDCEEAGEELGAVTRAPLWPYTRVLRGPRDAPDQAPPGIKMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAU3</accession>
    <name>A0A835GAU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000170">
        <property type="protein sequence ID" value="KAF9413075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="970" mass="107192" checksum="8C0202349D9653FA" modified="2021-09-29" version="1">MDCLHLQLYRDPKDRYKKGQTKASLSLQHFLGFESGFTLDKESNTIAIICQDVTVVLAFETRERLIAWQVKVGGQLGSSKQFLVMIGGGGSKKLPAGPARMHIQGRRFALTSGVPPRLLGLWELAHLRRYGVVEGRFCFEGGSHCGKGEGLHMLITDQAQDITDAFDMAAQNTLQRTPAASRKSTGNKTRPSTRLSDFNSADQSLPDTASALYEENFFGEDCGGVSPFWPSDERRLYDDDVEIGARPPWTGADHITLERCNNCLTKLGAISRSSTVALTPGNTFNPAWTMEAVPESSSDNSSNSTEYLTPRAIKKSLEACQCKDKPPERPPKPARLDLKKPPAPLPVQACSCTLSDNHNHVINNPKVGPYENYDVPKTVHTEIAPSEHYDTPKRIKQAIADDLFKVTNSSAPGSLVLKKNCGCILKFASKKKPVIVECDEAIQPVECPCQKVTNWANNLISLPYCKRTTAEHVSTELLTQQKSEEMALYATIDVSRKTNRQSAVSTDKENTSEINETPFTNYQNIEPKEEEKYEGPYANYENLEFALSLEYYENAKDLLKKAGVTQNELDALSANIDLAVNSIPKKSKLCTKCGHSQTAINKQDTKKIRNDEYLLMEPANEPKHEYCSKTLGPNPGYTPMSPNPNWSQSLKHPLHKHRVEIEKSLSIPALTGTESRMSIFGVSNSSKDAIQKRSSSVDSARLLEDLKEFDSSIGSHATSSSLETLRNLAIENRRTSSPCDNEAECYDCCKSSGSENKTSEESSCKEIPHLRNKLMDNAQIKRSSSVPCKSGGNRDSSSSNDSGVSSCSMKHGADYNEFEMPLTSGHSRYHYMVHKRMRGNMSGCVHSSLPRKSKSSDPLRDMSMQLHKTAVPAKSSSAEAEVPVLPPKQFKGVMDTHSTSSGTSDMSDYIETLSMTSSHSSSDTPMGMRLSRQPTNTLRPRSGKEYHNIDPILTSMYKNGKDLANYTNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBN0</accession>
    <name>A0A835GBN0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBN0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="571"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="823" mass="94271" checksum="1F0265724ED21842" modified="2021-09-29" version="1">MRRKSERTASKKGKASPEKKIEKVKRPRTRRKKQSSSSENESADDGSPVREVESVVDAEKKPPSTPAKEDSPEEAQDQVWRVKTTEASGDIKKLKICLTRPPSTPERVDRSPRSKRKHSRATSSSDTPSVEGVEERKKPKHPQGDEPDQDSSQFQDQDKSSDEVTQSETVEDIETPVSTTNEEMKVDESKNVSQSSEDIPTSKETASPRQDDVEKASDADTTVVSPKSETRVASPLVEVNPEPNSDIQDEQPSNSNDNKPQATTDTTEKESPRRTRSESVDKSEVLELHPDDSKAQISLQKKIPIRLKEDTKPVEPQEEKSTLPQHEEESTEAKDEEKPIVFQDEEKPASEEQEVSINEENIHKETEKVESDCKEAINETDVVESSEKVIKENQKRKLSTDNASQPMETEPAKVEPEQVSQQPIELHRSDSVKSTKEEPVANGQAAPAVVPRKRRWGSRSSKLTTQKSITISTDVLKDIIPDVKPVEFDEVIEEKKHRRIEAQERIERPVLPKIIIDNTDNVELNKESEEDQDPHTPKPRDLASNRKISIIKDNDSIIARPPSPPRNKQSCILYITNLVRPFTLPQLKNLLQRTGRIVENGFWIDRIKSKCFVEYETEDQAVETRHALHGVTWPVSNPKTLQVDFSTQEAFEKAKSNEETDATPVSAIPGTVEDWLREQDMKRDRGDLEKPWERKAATREWDLGKNEKDKDNKDSKSKREERPADKRRHRSQEKSPEPGKYESRKFKKKEEEAPAKLLDDLFRKTKTTPCIYWLPLSAETLYDDMTNWLLCVMQIAIKEEQRRQHMAEHERRLQELRRTHRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBV4</accession>
    <name>A0A835GBV4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_009702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000222">
        <property type="protein sequence ID" value="KAF9411510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBV4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032753019" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="61"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9411510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="33627" checksum="1CA24A8556465DC6" modified="2021-09-29" version="1">MVAVTALLLVLALVSVADFQEAVDTECCADAALDDAQNTEESEQELDVELEEACPELSGQIIGGRPTSVQRHPYQVSMVLNGNSFCGGFIISQDYVLTAAHCVQKRSKFEDIVRRVYRFGISGVKAGLVTTSPTAIRLRVGSTRRDSGGRIVRVANVTVHPQYGRPQFDNDIAALRLARPLTFNANIRAIRLPQPRQPVPLVRLTVTGWGLTAVGGRRIPRIMMEANVPVVPHWLCRLSYGQSLTNNMFCGGHFLIGGVSSCQGDSGGPAVFRDTAFGVVSFARGCALPLSPTVFTNIASLRNWITDNTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC31</accession>
    <name>A0A835GC31_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin-conjugating enzyme E2 C</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="12">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">(E3-independent) E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin carrier protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-protein ligase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HF086_017457</name>
        <name evidence="23" type="ORF">HW555_009932</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BAW_Kor-Di-RS1</strain>
            <tissue evidence="23">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.24" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000846">
        <property type="protein sequence ID" value="KAH9629942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC31"/>
    <dbReference type="SMR" id="A0A835GC31"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000039">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="19">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF9411218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9629942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="176" mass="20166" checksum="D5669D5646363E28" modified="2021-09-29" version="1">MAQNINPHYASSSNPAKQNEDTIKLKDNHAVSKRLQKELMELMRCADKGISAFPESENLFKWIGTINGPQDTVYAGHKYKLSLEFPNSYPYAPPMVKFITPCFHPNVDTCGLICLDILKDKWTALYDVRTVLLSIQSLLAEPNTHSPLNQQASYLWPNQPAYKKYVDEFYNKHRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCP2</accession>
    <name>A0A835GCP2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCP2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029391">
        <property type="entry name" value="CSN9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28562">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15004">
        <property type="entry name" value="MYEOV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28746" checksum="F99DB3DA2E6BF16A" modified="2021-09-29" version="1" fragment="single">DCLGPKRYLKIMEKYTVPNIPTTQQVLEDIFDDEIVQARDHPIKLVEGNESLHNAYCSYKNFKQLQEDVMRQDGLNSKLDELNQKLVENITTDEMFPEGVGPYMDLEEAGGPSNLLMDLAANEKAVHSDFFNDFEDLFDDDDLKIDVATINEYLRSTYVFKDFGTILFALSMSSSEHSPLSKPEARKETLAKTILTTLLEDHYQNHVSFLKHETWQETSYYQCLVLRFNLNSLQVLWGNSLCDLHIFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEF6</accession>
    <name>A0A835GEF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000174">
        <property type="protein sequence ID" value="KAF9412938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF9">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="73"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="431" mass="47225" checksum="3A058E9FDA28B699" modified="2021-09-29" version="1">MKQKTTAERHSRIVRSVGLVAVLGDSAALQPVRPRTVHDTKSGDLLSEILHCGARVVTNAESTGEFSPVVTATCKTGVMAIHIQFNQPFNGVTHAREFRTPACMALGNGTESLSFDINLMAPQGAPDYCGVFWNNRTDERSLPLAVRVHRTLELADDKFYVITCGKAGFRNARNETSLVSLRMLDSQGRKVLNAAFGLPYTLRAEISKPDGTHGIRLKNCFAFNMRNYTADLLDNRGCPMKQQSLVVKSETGAAELAIASMFRFPDSSQVNFQCDIAICKGTCSVIDCSTEARYEKGDEESTVTASTGIFVLDPNDNGVAALACSDGSVRPLWLLYLAIALGVMFIVMLLVNCFLCTAMTCSCARTDVIEKDPSVVEDYDPYRSWHGSQYGSRYPSSTIHSARSVSDNSDHYAIVQSRPGSRHSGMHRNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF76</accession>
    <name>A0A835GF76_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase</fullName>
            <ecNumber evidence="9">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_008348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000160">
        <property type="protein sequence ID" value="KAF9413411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF76"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06895">
        <property type="entry name" value="PX_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000351">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000048">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="159"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9413411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1270" mass="145376" checksum="6F80F3BCB22C10DC" modified="2021-09-29" version="1">MYTSVGFVPCNGQHISYQHSNGYRVITTEYRENNITNKRMERKDLTLSFHNLIKRDEQLYGYTNYGMDTPTPAPSASGDCLAGFGFPTMDSLSPVLDSDFDESLAVPESLSIIEGDKVDNKEENGVGVPRQTTVPFKYIHNPPVKFNSVHRKVFIPGVEIKVRFVENERSVTTHLLNPNLYTIYLQHGEFNWTIKKRYKHILYLHQQLTLYRTSLDIPFPTKTHKTRRASFKNTVDTEEKAERVAMQAVPRSNSRRAVRPRKRKGALPRFPKKPEVMVTYEGIQLRMKQLEEYLYNLLNISIYRNHHETVKFLEVSNLSFISDLGGKGKEGLILKRTGSTQPGQAGCNCFGLLGNMVCVRCNYFCTGLLCAKWQERWFFVKDTFFGYIRPRDGVIKAVMLFDQMFEVSSGMYSTGMNHGLQILNQSRQMVIKCWTKRKSKEWMQHLKAVANQTARDFTYPNLHHSFAPPRASTPVGTLVDGSAYLSAVADAMELAKEEIFIADWWLSPEIYLKRPALNGSYWRLDTLLKRKAAQGVKIFIMLYKEVEMALGINSFYSKSKLASEYIKVFRHPDHAKAGVLFWAHHEKIVCVDQTVAFVGGIDLCYGRWDDYKHRLTDLGNEVQPKTLLRMKKQTSSSPAVDRTCRIPTDWRLPWNSLRAPRIYATLKEVKEETEKENNNEVKPETSATENSENLPVLEPGDQLLIRSANPQIDPTKRESALDTPDVQRRNVLDKITDRGKNIISILYPPYEEERNEQKFDDSERKKAEKYALSTDQILLTDALGIKPAEVSSRQVSQPTPLAQVIEGRVITEETKEVLEHKEGNSKLWIGKDYTNFIVKDFNNLDLPFVDLVDRNTTPRMPWHDVGVVLQGAAARDVARHFIQRWNAIKLEKARQNPNYPYLLPKAYADIKPLQDLDKVLEVDINNVSCQVLRSLSSWSGGFLDPDTVEQSIHEAYADTITRAQHYVYIENQFFITQSRSSLAVRNQIGEALYNRIMRAFRAKETFRVFVVMPLLPGFEGEVGAPSGTSLHAVTHWNYQSICRSREAIITRLYESGVPDPFEYITFHGLRTHSVLGGEPVTELVYVHSKLLIADDKTIICGSANINDRSMIGKRDSEIAVLLQDEQFIDGTMNGEAYPCGKVAGALRKRLFREHLGLMGEDLDKLGVSLDDPCCHEFYRNYWKAISKRNTDLYEDVFHTIPTDAVHTFAELKKYQEENECLWNKDPALANRKIDLIQGYLVDMPLEFLCNETLTPRNTSMEGMLPTALWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFE3</accession>
    <name>A0A835GFE3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HF086_003761</name>
        <name evidence="6" type="ORF">HW555_007226</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000093">
        <property type="protein sequence ID" value="KAH9644262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFE3"/>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000525">
        <property type="entry name" value="rab-like protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9644262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="244" mass="27666" checksum="2C1A3B7A50DD1610" modified="2021-09-29" version="1">MAAIEKVKVVVLGDSGVGKTSLTYLIAHNKPLLSPGWTVGCSVEVKLHRYKEGTQAQNTFFVELWDVGGSNGHRNTRNVFYQPTHGIILVHDLTNRKSQINLQKWLSEILNQDSSNPMAHVDVDPEQFLGSTQIPILVIGTKFDMAEEKQRKNQYRRLASSIAEQCGADEIFVNCHQARSLAAGTSNSVKLTRFFDKVIERRYYSRVSPFADKRRVPPYIMATSTPLSSFKNTHYMSPRFYHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFE8</accession>
    <name>A0A835GFE8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="3">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_001343</name>
        <name evidence="11" type="ORF">HW555_007071</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9634141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFE8"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000126">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="352"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="523"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9415195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9634141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="674" mass="75760" checksum="95ECA7E4A3785426" modified="2021-09-29" version="1">MCGIFAYINHLTPKTRREILELLVTGLKRLEYRGYDSAGVAVDAADQKDIAVLKRSGKVAALEELLQEHSVDLSVEDCVDSHCGIAHTRWATHGEPSAVNSHPQRSGEDNAFVVIHNGIITNYKEVKTFLENKGYIFESQTDTEAIAKLIHHLYNQHKDYSFQELVEQVIQQLEGAFALCFKSRYFPNECVATRRGSPLLVGIKTRRRLSSDHVPIMYTNNKATRGVVPSVPRVNSHAHFQPEEEREVEYFFASDASAVIEHTNRVLYFEDDDVAHIKDGVLSIHRLSGSSTDPHQREIFTLKLELQQIMKGNYDYFMQKEIFEQPESIVNTMRGRLNFADSTVTLGGIKDYIPEIKRCRRLMLIGCGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMALRYCKRHGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFVSLVMFALVISEDRISLQKRRADIIEGLHQLDTKIRQVLALDNEVKKLAEDLYRQRSLLIMGRGYNFATCLEGALKVKELTYMHSEGIMAGELKHGPLALIDDSMPVVMIVMRDPVYTKCMNALQQVTARQGRPILICEEGDKETMAFASRCLQIPKTVDCLQGVLTVIPMQLLAYHIAVLRDCNVDCPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFN3</accession>
    <name>A0A835GFN3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hemolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_007773</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the hemolin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010560">
        <property type="entry name" value="Neogenin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF54">
        <property type="entry name" value="FI24025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06583">
        <property type="entry name" value="Neogenin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="272"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="364"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="534"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="630"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="788"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1087"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1106"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9414295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1182" mass="126036" checksum="D4F8F15CC5320A66" modified="2021-09-29" version="1">MHLSVGYWVNRWCTDSVGTRSYGGAAPGRSADGGEDALDPGVRFSVEPSDAVVVPGDAALLACSAASSRALRLHWRHSATAPPTRDHAISDTDKYRKQLSNGSLWISEMSASLAGHYQCVASVDGVGTIVSRVALVFLAEVPEVVGGPRSVLGAAGSAALLPCGVRAPARLALRLLAAPPDRRVYGAARLHAAPPVLNLNVTWLKNGSPVRLEASRMWLTPSGALELEPLRPHDAARYRCRVALAAAPHLYKMSEEMELRVSAESPNVESPPRFIATPQPATVMEGASVTFDCAAVGNPKPEITWLNNGAAIDLSDLDSRFYLVGSGSLRVQAARALDAGAYTCRAHSRLDSADSSAHLAVLTPPRALGPAAVLQARQRGDLTLRCDVRGRPPPAVVWLKDGDPLTPNNHDIAIVDGSSLRIQGVLRVDAGMFQCAASSRAGSALAAVRLLVLPPDDDMRNITVEVPSTGVSASTQPPQEEDFLGETSSAYTAPPLEYSELDDYEDGTDDEDSFHAAEGLELDQLRAGNVSGAAPRGLRAVIVKHRFVTLSWQPPHDGDVAGYAVLYKVKGSQRERVCRGGAGRHELNVAGLQPNTSYQFAVLAYTGHGTSPLSDTIEVVTAEEEVSHGPPVDLRAEATGPHSLRVSWGPPVGAPPPAKYSVHYTEEESGREQLEWIRVCAINANGSGPFSEWVSASTQRHELDEATVPPAPPPLTTRAGRDWISVWWGAAQGGVLVRGLVLGWGLGVPDDAARELPPHLHSHVIRGLESNAEYVISLRASNSRGLGPAVYATVIMLSGTTAVVYWTDPTLPKGQTATDGRRYVVRWSSAGGRARTFNATDLNCMLDDLKPYTHYEFAVKLIKGGRESAWSMIVSNTTLETAPGSAPRDLRVSPAAPPASAARAVDLVWQPPAKPNGSSASAAIKPPDLWIHHDQMELKHMDKSLHSSASKSTTHTLLYSLLPHYTLSAGSVEGGALMSSTLTLGRAPPAEYEPARHPPPPASLDRRHHVPTYVESRSVSAASDDTCVVRASPARRCDRCDACDRYDRCDACDRCDYMPRPMTGMGVGVGVGGVGGVGCASTCERRPHARMPHPDQSTPLLAGVAPLGSPQSSLGSLPHPAHSAHQHLQHQPPAPCGAVPHCADELEPLTPSRSTERLHREMQNLEGLMKDLSAITQQQFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFS5</accession>
    <name>A0A835GFS5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_006050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFS5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF240">
        <property type="entry name" value="PICKPOCKET 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9416620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="549" mass="62000" checksum="D0B4661CE429B3B1" modified="2021-09-29" version="1">MKNTGYPTNHQKHSKSTTKCMSSAMKTVTSFSKDFCNETSMHGFIHIAAPRRHWFERLLWIVATALCVWGALDVALGQLQRYNESPTVVTMEKDFRSWEFNLPAQTLCFKADLLKELELKGSKQPRHEVLAFVAIPWIRGLGVYGWKIIHCEMNRVDNKKLPSVVKKYFGTDPSDDQYQFYVRLVKAIANSDILHLEGFQEFGDMETSVDMFGVAVDVMPDNVIKTKSSDGVAYTWIPVMTEAGVCHTTNCLAIADVAIGPLKSNATAGWPGSCAYASVSCFIITDITANGRFYVHSPYDLMDLSVDWTDIILTLVRATELSVMESRCGRGVKDLSPSRRGCSYMDEPRLSGRKVHSTNTCRLACRSKLARELCDCVPFYYFYDDGPTCTPKGMWCLAKNAQKLLKNDDRKCSCVPQCIDCNYKEMIIEEQVWKNPPFNQHGSIKYSVQPPQTRYTREIVFHFQDLVVSFGGAAGLFLGASFISLVEILYIMVARLFRHISGAEDHNSKAAAVTVKEVGVSHETLRINYLTAILEEHKDYDKKPSSYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG38</accession>
    <name>A0A835GG38_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000127">
        <property type="protein sequence ID" value="KAF9414716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG38"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13484" checksum="E56AA318813C45D5" modified="2021-09-29" version="1">MVGSSTKVRKTSIRMTAIKEYPFDLSDLQNQPSVAGDTRPTQTQPAQTQPAATQPNPPAIKPRVSVPSLEGKRKVSIMADESSKDRENLPSDRMSHSSLSCHYDSYLPSDSSLETDALNRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG97</accession>
    <name>A0A835GG97_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_016291</name>
        <name evidence="9" type="ORF">HW555_007297</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000687">
        <property type="protein sequence ID" value="KAH9632810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG97"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000004">
        <property type="entry name" value="39S ribosomal protein L14, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9632810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="150" mass="16771" checksum="F8EA9F5363A9A66E" modified="2021-09-29" version="1">MFKSLINKLHSAQISRTFHTTACMNEVRLLSRLRVVDNSEIGKRAMAEGKPPKVICVYNKKHVGYIGDRVLVAIKGQKKKGILVGMKQKQNVKVPKFDSNNVVLIDDNGTPLGNRIHVPIPTILRTILKEKTHSKGADYTKLLAIATRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGF1</accession>
    <name>A0A835GGF1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_016571</name>
        <name evidence="9" type="ORF">HW555_006310</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000737">
        <property type="protein sequence ID" value="KAH9632011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGF1"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9632011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="132" mass="15022" checksum="36B12A3FF9D2CCA0" modified="2021-09-29" version="1">MADEEYEADDAGADYDDIAEEDDNIEETEEQEEEGYNVQCLAPGQAGGGVEKSKRITTRYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLQIAMKELKHGKIPIIIRRYLPDHSYEDWSIDELIIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGL1</accession>
    <name>A0A835GGL1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HF086_016741</name>
        <name evidence="18" type="ORF">HW555_006444</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000096">
        <property type="protein sequence ID" value="KAF9416121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000126">
        <property type="protein sequence ID" value="KAH9643534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGL1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022604">
        <property type="term" value="P:regulation of cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21780">
        <property type="entry name" value="MobB_Trc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05599">
        <property type="entry name" value="STKc_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000393">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="105"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="412"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9416121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9643534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="499" mass="57182" checksum="A2EA38C50B64F58A" modified="2021-09-29" version="1">MTDARASSSSLTAGEGVLEMTGTDNIRFSGSTLDKATKAKVTLENFYTNLITQHLERKQRLEKLEESLKDESLTESQKKEKRQQHAQKETEFLRLKRSRLGVEDFEPLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVAHVRAERDILVEADHQWVVKMYYSFQDPMNLYLIMEFLPGGDMMTLLMKKDTLSEECAQFYVAETALAIDSIHKLGFIHRDIKPDNLLLDARGHIKLSDFGLCTGLKKSHRTDFYRDLSRATPSDFTLHFNFSYAVSTSSSAMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPQADWWSLGVIMYEMLIGYPPFCSESPQETYRKVMSWRESLTFPPEIPISEEARETILRFCSEPDRRLGSQRGIEDVKSVSFFRGVDWSHVRERPAAISVEVRSIDDTSNFDDFPDVKLEIPATIMNIVYVVAASAPIPQDGEVAYKDWVFINYTFKRFEGLTQRGTPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHG3</accession>
    <name>A0A835GHG3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_001357</name>
        <name evidence="12" type="ORF">HW555_007069</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9634155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHG3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000107">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="204"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9415193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9634155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="450" mass="48500" checksum="B6447CAF6BE8D36E" modified="2021-09-29" version="1">MAKGGNYNGDLFEYIKVSEDEDDSNAVEIPCEMDGTLLLSTLVAQFPGACGLKYRHPDSKSIRGIRLSDGKLHPPTEVGWGKLLYICVFPKENKRKMEDVSPENSAAKTKRLEKKLTCSDLICLGLPWKSTEESIKQYFEQFGEVVMVQLKRDKNGSFKGFGFIRFATYASQMRALAQRHNIDGRWVDVRIPNSKEGVVPQMPCKVFVGRCTEDMTADDLREYFSKFGEVTDVFVPRPFRAFGFVTFLDPEVAQSLCGEDHVIKGASVSVSSAAPKIKTKSQNWKEDSYGPNNWEGNRSGGSSGGPSNNGGNSNIDSLNMQNLGINPNGGPPANFNLPISLVAAALNQAGWGGFLGGPGNSGPNNWQGGPPQGNPGKNWNGNQNWGQNGPPPSWNQGGGNPGWNGGGKSGNNWNQGNWPNGQGNWNSNGNGGGSSSGSGSGGWNNNKPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIA5</accession>
    <name>A0A835GIA5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIA5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032427290" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="59856" checksum="E54DD39EB7EFD82B" modified="2021-09-29" version="1" fragment="single">DTLKIILFVLFVVQYCDSANILYVVPFTSKSHYIMLKPIGLELARRGHNVTVITGHRVEKPPPNYHQYMVDEKEIWDVIGGSRPNVFKMVEISAEKFHEDVLWKGGLAFTELTLNSTQIKRLLHEDTKFDLVISEQFFQEALYTLAHKYNAPLVLVTTFGNCMRHNIVARNPLQLATVISEFLDVRDPTSFRARMRNWYFTIYEYVYWRFWYLEEQEKLVRKYLPDLPKPVPSLYDLQKNASLILLNGHFSFDTPAAYLPNVVEIGGVHLTKSDTKLPEDLQKILDNAKHGAVYMNFGSNVRSSELPEEKKRAVLNVFRKLKQTVLWKWEDDKLENKPDNLIVRKWLPQKEILVFISHGGLIGTQEAIYNGVPIIGVPIYADQYNNLLQAQSYGFGKILEYHDINEETLSEVLHEVLTNDSYRINAKELSERFKDRPMDALETAMFWIEYVIRNKGAHYMKNPALELSWFAYTMIDVYAFVLSLVLVSVFVLLKIVKLILSLMELKPMKKQKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ79</accession>
    <name>A0A835GJ79_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ79"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="362"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9417095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="544" mass="62359" checksum="AAEED133CD765ABA" modified="2021-09-29" version="1">MEEVITEHETLNTVIEMSDPSGLMEKEMEDEEQYQPEKSQEECAIDEDRRPIKRNRSEDEEGWIEVRGSKGKKYKSETIEIYISSQDKMPKQFALAKLFKEEGIKDIEKIRDIDIDLTEDEMLKRIECTEPAQLISVQRLMRRNSDGEGWKPSESVRLCFKGSFRPATISVDGLRIRVEQYIFPVTQCSRCWKLGHTTQRCPSTKIICPKCSGNHNNCETTLFKCPNCSGQHMALVRSCPSYLKEKRLREIMAEYNCTYRRALTMYVPVKETNPVDSATTKTEQKNWSNSQAGKLSFSAVVQKPHVEVTTQPPEKDTQYNTAKKPQTKPHKPKQTEKPVEYETWIEVDAMDSQEIAEEDESDLNAHHTNWSYKTDTRGSQIHDALLESNFVILNDATSYTRVKLVNNVLQTSSPDITLATQDIAIRLNWATTNENLGSDHLIIRAERVSFRLKFDVDLREVGVCNRILACPMSEEAQAIYKLVNLAFKRRYSTPNGNVTVAKMADTKAGTFRFSRSSWAGRTIALPFANGAEFNQYRLVTVRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKI6</accession>
    <name>A0A835GKI6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10618" checksum="3DB084CC5E625E75" modified="2021-09-29" version="1">MDVDSGFPGSDSGGGSVLSRKRFQTPQLEARVYHQATNLQPIEPPTPPPMPSDPVQVAKPKGRFITAKILNPKKHSLQTENLRVSKSEDSNLDIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLF6</accession>
    <name>A0A835GLF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_008707</name>
        <name evidence="5" type="ORF">HW555_004282</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000047">
        <property type="protein sequence ID" value="KAF9419111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000098">
        <property type="protein sequence ID" value="KAH9644218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9419111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9644218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31694" checksum="CB4D9E6060790001" modified="2021-09-29" version="1">MQEDGYVVLEEFLTPSECDEMVAAGTEFTKNLPPKEQRIIFSTVNSEKQQLQDEYFLNSNDNISYFFEESAVGPDGELTVDPSISLNKVGHALHYQHPIFRCYTYCDRVKEVAKALGFKEPAVVQSMYIYKNPGIGGEVTAHQDITYLHTSPVPPIGFWIALEDATVQNGCLWMVPGSHKSGVHRRLTRNPDKDSKDKLIYDNPAPFYPQSSFTSVPVSKGTCIVIHGNVVHRSAHNHSGSGRPAYTFHIIEKQDNQYSADNWLQEGARAPFTNLYTTSQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLT1</accession>
    <name>A0A835GLT1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF424">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="196"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="290" mass="32212" checksum="63D7652FD3C6CB2B" modified="2021-09-29" version="1">MRTRDRLAELQHLASGAAGGVYCDTVQPGQPDAAAKHDAHIQDIFREVERMRGWIHELDNNTQLIRRLHSDPTFHTNKNLQEQLDAAVTASNATGLKVSGALRQFEGRLSARNDAAARIARLQYAACRRLYADALQRHHAALDAVRAHQLLLLQHQIQLTQLSVSEEECEALLESNNIALFVDNVRAETAEARRALRDVEARHEELARLEAALRDVRDLFTQLAHLVAQQQDQVDSVEYYALQATEHVGSGGTQLLKGTVSRTKARKKKFGLIVCLAAGFAVVLLVLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLV7</accession>
    <name>A0A835GLV7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032761001" evidence="1">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="37136" checksum="B0A36DE77DC75BFC" modified="2021-09-29" version="1">MFRRFFLVAVFIVIFKNVTTQTIDDITSQNPVTTTSSPSTISKWEQLIPALQLLKGNTKIKKDKLHNVIKLIKQVLSEEMENKEDSTIVYDEATDTEVIDNVEEREKDDPLSIPIIDFENIVDDRLKDIKEIIDDRNYMLVEPKYVCKKDVDEEKNKTADVSNVLNKISTALNRLKEQNHPEPVMETPNLIPIFRSKENSNNLNSLQHSNSRQSEMNSISNFPAFTIPCQKASDILAETATFPLPKDVLCDDPSVNLKAMAKKTKLNLDNLPFKNIVPDSISCVDSDDSLAVLFKPKSISLMQVYGNLLKKITITVLVPYYVSKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLY4</accession>
    <name>A0A835GLY4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_003455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLY4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF141">
        <property type="entry name" value="CARDINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9420234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="622" mass="68955" checksum="6FC3466E1FBD1BFC" modified="2021-09-29" version="1">MHGHFLRPGGSGQGPSLNGSFPVPAYCSTTPIPCALSRYRTTDGTCNNLDYPLRWGVSKTPFRRVLPADYGDGISSPRQGVDGAALPSARDVSVTVHRPSYAHDSAFTVMLAVWGQFVDHDITATALSKGQNGTALSCCDPNQIPHPECFPVRLDEEDPFYQDYNITCMEFVRSAPAPTCHFGPREQLNQATAFIDASTVYGFAEARSASLRSFVGGQLRMLKIGATQLLPPSTDPNDSCNTAEMNAKGRYCFESGDDRANENLHLTTMHLIWARQHNRVAAALRKYNPMWDDDTVYQEARKILGAQMQHITYTEFLPSILGWDVMWALNMTVEEEGYSNVYDPTVDPSIANHFASAVFRFAHTLLPGLIHNTDKSTGTIQYTHLHQMLFNPYTLYTKKGPINAVTSAMATLVHTVDPHVTTELSNHLFEKPVMANTSDAENKKPGPCGLDLVSLNIQRGRDHGLPPYPQWREHCGLSRPKNFTDLQAIFDESSLSRICKIYNSVDDIDLYTGALAEDPKGRLLGPTLTCLIADQFYRLKVGDRFWYESSDATIAFTLEQLTEIRKTTLAGVICANEDLLDQAQPRVMEAVSATNPLVDCKELPQPNLRAWAKPKPSKTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM53</accession>
    <name>A0A835GM53_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="96"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="431"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="780"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151482" checksum="8F55D1BCE4718E2F" modified="2021-09-29" version="1">MESKVVLTEKNPHEKANVISKLFLTWSFSLFRKGYKQGLSISDLWQARSGDASGRLGDRLEEAWKTEQEEARKNDAKPSFSKAIIRTFWFEYMLCGLCVGFLFMVVWPLIPFTLALFIEYFSKEKTPESYREAHIYNFLMNLFSTLSALMLNHTQLAQGRIGMRIRIACCSLMYRKILRLNRAGLNNTEAGQVINLMSNDVNRFDLVTLFLNYIWITPIVVPVVCYLVWQHVGIATLAALAVVGVQTILVQVYLSHLQGKLRGKIAKRTDQRVKVMSELVDGVQVIKMYAWEKPFEKLVHQLRKMEVGYILRTSFVKGFTTALAVFTERFILFSAIATFVLIGGEIRAQTTFSLVQYFNLMQLVCNIFLPMGLAYLAETRVSIKRLEEFLLLEENEPEKVTANMVLDSKSILADGTEKEKKVQEKQRVTGMTISNVTASWTKDSVVDTLRNVTINAAPGEFVGIAGGVGSGKSSLLQLILGELVPKSGTVNLGGAKVSYASQEPWLFVATVRENILFGLPYDRIRYKKVVRACALLRDFELLPHGDSTLVGERGISLSGGQRARIGLARACYRKADIYLLDDPLSAVDTHVGKHMVSECVMGLLEKSTRILVTHQLHHLKGADKVGEVEIQGSFDEVSRTPLFAELLQDEEEEATSGGEHIKMQRSISVRSQASSISPAEGIGGEDLIEQQVEIEEITGTGRVPGKVYSKYFGIGAGCCLLSSTVLAILFAQFITSVSDLWLTHWMNDVESQYISNMPLFRVENNTIIPSNDTLVNATESAVTEGAITTTLGAITTAFLSNDTMETSEAILNATGFDTTIVAPAKINDRFYIYIWAATIVGCIIATSVRAIMFLWVCMRSSIKLHNEMFKNILSATMRFFDTNPSGRILNRFSKDMGVVDEILPRMYLDTIQVFMVMMGILVMVAIVNPYMLLTTGVCAIFMYGLTVVYLSTAQAIKRVEGVSRSPVFSHVTATMSGLGTVRACEAEEMLKTQFDDKQDVHTAAWYLTLVTNTAFSIWLSLCCSAYVVVVAYTFLFLDDGNTKSGNVGLAISQGLILVNMVQYGVKQATEVISQMTSVERVMQFTSLPQEETEGPNPPANWPQKARVVFKDLTLRYDKDADPVLKKLNVIIESGWKVGVVGRTGAGKSSLISALFRLAPIEGNVYIDDVETGKIALKELRSKIAIIPQEPVLFSASLRYNMDPFDKYSDIQIWEALEQVELKSSISSLSSPVASGGSNFSAGQRQLLCLARAALARNKLLVLDEATANVDPTTDAMIQKSIRRHFADCTVITVAHRLHTVADSDRVVVMEAGQIIECGHPHELLQDDEGPFTKMVKQLGPASEQSLRDLASKAYSEHNIKNAMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM57</accession>
    <name>A0A835GM57_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM57"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="561"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="810" mass="93512" checksum="2E1DB42ACA00541F" modified="2021-09-29" version="1">MIKMETERQKFYKHKIKRILTKDDASSVIDENDKSTVTLLGSTSYHKQVNDFSIMNSSNTDQQSETLLDDKVEPNFHAITVNETKMIDENVSDLKDRDIIINEVIIEVEREYPEEIDKSEVIQIERTVSNDSLQPTITDIIPEKDMDLLRKSLEDDKADDNGQLIPTTDDHPIRQKNKRVVLKKSYVDFLSEDEDFAWDSTSWKETEESSSDEDNNEAPRKKNKKIIKDGKVGDAGVKKKRINRKKVQKESRNKGAQYVKADGSIVKARNMKPNPCVEKACPYKCQEITTEKRSAIFEHFWGLSAERKKQWIVSMSSKQSIKRKRSKDSIYRNNTYFYFINDGEGRRQVCLKFLMNTLDVTQRYIYYTLSTQEHGMSKEDGRGKCIPTNKTPNEIKESAKSFIKRLPAVPSHYCRKDTTKLYLPVEFKNIKNLYRCYKTELTSKGADVVSEKIFREIFNTNFNIGFHVPKKDKCIKCLHFEGQKPEDCAELKDHLDEKEASKKRLDCHRQLGKENPSFLCTSFDLQKVLNTPHGNNMLLFYSRKYAVFNLCFYESITRNGFCFIWGETEAKRGANEIATIVQKYIQNVDSRGTITSLILYSDSCPGQNKNKIVLAAIHNALLKSTNLLTIQMNYLLPGHTEMSVDSIHSTIEQSVRNITVWAPSQWATISELARKEPAPYIVENLTHEDFLDFDELSDKYFKGNLVGKISKIRIATFKKSHPNQMKVKLSMKDDAPEESVQIIARPRSINSRYNSSLPITKAKYMDLKKLCDTGVIPKIFHKEYLNLQHSNTTKECLIDTDIEDVDENDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GM58</accession>
    <name>A0A835GM58_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_003329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GM58"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF237">
        <property type="entry name" value="PICKPOCKET 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9420407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="465" mass="53255" checksum="8E8C328DAA23EB8A" modified="2021-09-29" version="1">MPKKKQKKIDSAYYVSLIERITTLHGTSHFTSRTGRSLLIWTLAVFGNVMLTIAFIIVIRQKFNENQIVTVINANCKVNQVPFPAVSICNYNMVSARESQNIAKLLRQYNKPEEEIIEFFNALPSLKNYGKSSRGLGNFSDIMTILKHHVFTVDIIMEEVHQKCENLILYCTFNRKPKDCQDMFSLVKTYEGHCCTFNYAALNDASEIPLLPSEPDPDLEYYDDQNPDGGISTNPTIIATSESGRGSGLSVVLNIEPNDYPSWSPVPYYGVKVLLSDPNDYPETTVLYRYVTFGESVDIKVEPMVFQSDSNVRRVEPQYRGCWFHDEVLLSHTNRYSYETCVTECKMKNYINACHCVPYKYPREKSTRICDFEDLKCLNNVTVHKSTKEMKCDPICYMECRDKKYTATSDLTPFLLDNFPVEVTAGRNVSEMAALQVYFSKSNCNCYKLTLLIDLSYFVGMYAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMB6</accession>
    <name>A0A835GMB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMB6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9419462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="306" mass="35089" checksum="C43EEFA5FD416D7F" modified="2021-09-29" version="1">MSDKIYSNFVKASLPEEDINIIPDKSVLSGEEARTLYLEEIKHAKAPNRLKTQGVEKKKKVITEEKTPLSNKDLFITIQNNDVDRVKCELDRYPDKLNIVDEFGWSLLMIACQANSVDVVKLLLKRGIDMSVRDKAGNSARSLVIKNKNYILADILLRYIQKDAPPKLNTKQTSVTVKLKEEFICELCNKTFPDKEEHLSSTIHNITASRGKKIPACYVLPETNRGYQLMLRGGWDKQSGLGRDGSGKLYPIKTVQKKDRKGLGHAKQKPIDNKTQDNVKHKNRMKLARDHRSDKSFEIKFRREFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMI6</accession>
    <name>A0A835GMI6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_013380</name>
        <name evidence="3" type="ORF">HW555_002327</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000432">
        <property type="protein sequence ID" value="KAH9637894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMI6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032443743" evidence="2">
        <location>
            <begin position="24"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9637894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="467" mass="47800" checksum="67155757ACC5ED1D" modified="2021-09-29" version="1">MLIIKRVLFCAFLLAVLFEPILAKRGFSGGHSYPKSGGLSGGGHRSGGLSGGGHGYPSSGSHGYPSSGVRPPSHGYPSGGGLSGSGSSGGSHGYPSSGGLSGSGSSGGSHGYPSGGGLSGSGGNHGYPSSGGSHSYPSSGGSHSYPSSGGSHGYPSSGGGLSGNNNNRYPQNKPTTVHHTTNVYNYHYSPPQRISYAPPHGGPPVNYPVYHGTPPTYVYQYKNSGSKYGTLLAGLALLNLGTLAGAAYAHSRTQQYKPQPGEVCKFAVKKDNGDYEETRIDCQIISSFILEDQAQRSTGTNSTVSVVTVTNTTVTNSTNMIAANPTTPAPVPVPGNVLYAMLPNGTLVPVNQTAPPTTAIPLNVPMNASVGGLAPNGTLITTSSVVTTTTNTTVVNALDVKGKPVQVTPGMQCFVIRTSPTHNMRKSVQCGLLQTYADKSIRKNSATRNGPMFTTILAAVVAFCVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMJ8</accession>
    <name>A0A835GMJ8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sensory neuron membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_003072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMJ8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF69">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9420724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59374" checksum="E6B69430CCFD981E" modified="2021-09-29" version="1">MLLPKELKYAAIAGGVALFGLIFGWVLFPTILKSQLKKEMALSKKTDVRQMWEKIPFPLDFKVYIFNYTNAEEVAKGAVPILKEIGPYHFDEWKEKVEVEDHEEDDTITYKKRDVFYFNPELSGPGLTGEETVVIPHVFMLVRHGINSTQRKASHVEYGWQSDERIFDDPPDIFLRVKAMDILFRGMMINCARTEFAPKATCTALKKEGVSGLVLEPNNQFRFSIFGTRNNSIDPHVITVKRGIKNVMDVGQVTAVDGQTVQTIWKDHCNEYQGTDGTIFPPFLTENDRLQSFSTDLCRSFKPWFQKKSSYKGIKTNRYVANIGNLAEDPELQCFCPQPDKCPPKGLMDLAPCIKAPMYASMPHFLDCDPALLSKVKGLNPDVNAHGIEIDFEPISGTPLVARQRLQFNIQLLKTDKLDLCKDLSGDIVPLFWIEEGLALNKSFVNMLKHQLFIPKRVVGVLRWWMVSFGSLGALIGVVFHFRDHIMRLAVSGDSKVSKVTPEEGEEQKDISVIGPAQEPAKINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMT7</accession>
    <name>A0A835GMT7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="24784" checksum="0ED34E63020C3C52" modified="2021-09-29" version="1">MKYKTSRTRNEQRKREKMSNQITNIVASILFILFSFAFYLTISFTPLTKEEQIERYNKMTENVEPFKKNLTECARQVKASMVDVENFLKRIPQASLQGKCFVACILKRNSIIKNNKISKENLLEANRAVYGEDSEVMARLKTAVGECAKAVEEIFEICEYASVFNDCMHIKMEHILDQVTMERRMEAIGKMTSNPDQWGEEEDELLKLVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN49</accession>
    <name>A0A835GN49_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN49"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="160"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9420492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="255" mass="28934" checksum="CE77968F1EA376FD" modified="2021-09-29" version="1">MTDHTESKMESDNINVEEFLPAKKTVKLKNIKRRAVSESGDGMEIEEFNGIQGKAKHSRSRPKKKKRNTEPNESKENLRKIPVPAHRYTPLKENWLKIFTPIVEHLLLQVRFNTKTRNVEIKVGPETKDIANLQKAADFVKAFIYGFEVDDALALLRLDDLFVESFEVKDVKTLNGDHLSRAIGRLAGKAGRTKFTIENVTKTRIVLADSKIHILGSYQNIALARRAICNLIMGSPPSKVYGNLRNVANRVAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN91</accession>
    <name>A0A835GN91_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_003302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN91"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9420552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="285" mass="32136" checksum="00370EEF5C720155" modified="2021-09-29" version="1">MADKIAVVTGASKGLGFAIVKGLCQKFNGVVYLTARNEKNGLDAVKKLNDLGLKPQFHQLDVSDEKSVQTFASYIKNKHGGLDVLVNNAAILEWDEVYPSYEAAKRNIDINYKSLLTLEKYVYPLLRDGARVVNISSSCGHLSNLKKQSWIRMLQDPDLTTEQINQFVDEYLESVKNGTFNKNDFADEGKHAEHRVSKIALTALTMVQQRKYEDRNISINAVHPGHMKTEMAQGGGETEPDHSAELVLYLILDASPKLRGTFMWHDRRLIDWCDAESDFACKDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNG6</accession>
    <name>A0A835GNG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_004362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9419035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032502384" description="Partial AB-hydrolase lipase domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="467"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9419035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="854" mass="95777" checksum="48CBC86323211D3A" modified="2021-09-29" version="1">MLRVELLVVIATCFYVAVARSSPQARKIQGLIKNIDTRYSDDIYEDANLDVPALITKYGYPVEEHSVTTEDGYILGMHRIPYGRDANNVANQNKPVVFVMHGLLCSSADFILMGPGSGLGYILAEEGFDVWLGNSRGNYYSRKHVTLNPDAILNTAFWQFSYDDIGNKDLPAMIDYILKTTGAEKLHYVGHSQGTTSYFVMGAMRPEYNDKIISMHALAPVAYMAHNENLLLKALAPFSSEIETIASLVGVGEFMPHSIIFTWAGEALCRDEVVFQPICSNILFLIGGWDEAQLNTTMMPVIFGHTPAGASVKQLAHYGQGIAAKGFRRYDYGTNLANYLHYGSFTPPSYDLSKVTSPVYLHYSTGDPLAEVADVETLYSELGNPMGMYLVPLEKFSHVDYMYGINAKELVYDGWIMLRGGLLVVTATCVALAAARSSGSSDDILQLLKNIDLRYSTDVFEDANLDVPELITKYRYPVETHTVTTEDGYILQMHRIPHGRDANNVPNQKKPVVFIMHGLLSSSADFVIMGPGSGLAYILAEEGFDVWMGNARGNYYSRRHVRLNPDALLSTAFWQFSWDEIGNIDLPTMIDYALEVSGQERLHYIGHSQGTTSFFVLGSMRPEYNAKIISMHAMAPVAYMANNRNLFLRVLASYGNDIESIARLIGIGEFMPNSVIFTWAGQSMCRDEVVFQPICSNIMFLIGGWNEDQHNSTMMPAIFGHTPAGASVRQLHHYGQGITDRGFRRYDHGSRFSNYRAYGSFRPPNYDLSKVTTPVFLHYSDSDPLAHVNDVDRLFRELGRPIGKFRIPQRKFSHIDFIYGINAKELLYNRIINLIKSMDANAFDEQNENTEYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNI2</accession>
    <name>A0A835GNI2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_001759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNI2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9422555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="71" mass="8110" checksum="098E0BA718F21454" modified="2021-09-29" version="1">MLRVMARGDECKTASKANHACKSFDVSAPLQKPVYQAPKYQAPKKPEQKKDYGAWGPIYKDKKTFTDMHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNY6</accession>
    <name>A0A835GNY6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="13">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_002802</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1). Mediates bisymmetric organization of the PR-DUB complex and is involved in association with nucleosomes to mediate deubiquitination. Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Polycomb group (PcG) protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of caly/calypso, Asx and sba (MBD5/6 homolog). The PR-DUB complex associates with nucleosomes to mediate deubiquitination of histone H2AK118ub1 substrates; the association requires the positively charged C-terminal tail of caly, probably due to direct binding of DNA. Interacts (via ULD domain) with Asx (via DEUBAD domain); the interaction produces a stable heterodimer with a composite binding site for ubiquitin. Homodimerizes (via coiled-coil hinge-region between the UCH and ULD domains) to mediate assembly of 2 copies of the caly-Asx heterodimer into a bisymmetric tetramer; dimerization enhances PR-DUB association with nucleosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C12 family. BAP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNY6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000002">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF28">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 12 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="15">
        <location>
            <begin position="14"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="12">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9421090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="509" mass="58215" checksum="E9121B6B0F843B66" modified="2021-09-29" version="1">MKNMPVEINSLVEGWLELESDPGLFTLLLEDFGVKGVQVEEIYDLHKPLESPVYGFIFLFRWIEERRSRRKFVEQIESFVRDEETINSIFFAQQMVPNSCATHALLSILLNYPNLHLGETLSRLKHHTLGMNPENKGWAIGNTPELACAHNSHAIPQARKKADKNAGVSTGRFTGEAYHFVCFVPINGHLFELDGLKPYPTDHGPWAAEEDWTDKFRRVMAERLGRDAGEQVHDIRFNLMAVVPDRRIALTQKLNALEMNQKRVKEAISKIGKHLRHLLSKRREIKEEGESLSEESNENSLNENIVQISEETILTALESSQLQLYDVDYTRPITIEIGANDRPQQDSSIILVDPVEQGAVVKFITINRDNQIVGDLYPTSITALVKSNDAPVLVCCETEPDQPIKLRKLLLTHSELNALMSSIVNEVQQCQQALNDENDKRDMYKVDDCRRTHNYDEFICTFLSMLAERGALGELVAAQLERGRSSRARRRRPRPRPRARPRPRPRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNZ4</accession>
    <name>A0A835GNZ4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000029">
        <property type="protein sequence ID" value="KAF9420725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF27">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033093579" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9420725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="495" mass="56430" checksum="3A74D9EF101AB140" modified="2021-09-29" version="1">MHRSRWPFLCLPILLAASACGSDILMVTMGGTKSHKMPFWELARGLIRRDHNITFISAFPADFHITGLEEIAPEGLVTYVRNYMSFDLVGARMRGEDQMPLKDVLRYGYEACDAFLSDPETRSFLRSGRTFDLVILDGTYPECALGIVYKLKVPFMYINTVGFYAMPLSNSGSPAPYSVTPFFGKAFTDNMGIFDRALNAIFHAAIIPFHAFSMQILQGVLRRNFGQQIPHVYDMAKNVSFILQNGHYSVSYPRPYLPNVAEVACIHCKEAKPLDPEIEEWISGAGETGFVYVSMGSSVRTTKMPLSAHRLLVEALGRLPQRVLWKQDVEQNMTDIPSNIRLYKWLPQQDLLGHPKIKAFVTHGGLLSMFETVYHGVPIVTIPIFCDHDSNAAKAEVDGYAKKLDLQYLTPEKLYKAILEVITEPRYKQEVKKRQVLLRDQKETPLERAIYWTEYVIRHKGAYHLQSPAKDMNFFQYYSLDVFLLIVTVLNILWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQR0</accession>
    <name>A0A835GQR0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_004068</name>
        <name evidence="3" type="ORF">HW555_000783</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000655">
        <property type="protein sequence ID" value="KAH9633354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQR0"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9633354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="172" mass="19904" checksum="D9C519E5E3F29848" modified="2021-09-29" version="1">MPRGKFTNHKGRNRKFTSPEELEEQRKQEEQKQKWRKEHGKESSSEEESEEEKSGSGSEDESDSDDDRPSKAKGVSGLIEVENPNRVVKKNKKLNNLDNLGEGEKPQLSRREREEIEKQRAAAAYQKLHAEGKTEQARADLARLAIIRQQREEAAKRREAEKKAKEETPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQR5</accession>
    <name>A0A835GQR5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQR5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="612"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="861"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1149" mass="132039" checksum="ADFE7CF90EB9A9D9" modified="2021-09-29" version="1" fragment="single">TDFFSNDPLYYRPFFQHVISGRRFEEVIRCLCVADDQAKGERKVLDFIKTLNNNFQLIYGPSKELSTDESLILFRGRIFFRQYIKSKKARYGIKFYVLTTASGYILDMIMYRGKYASAETGKKTQNIVLKLLEPYVFKGHHVFMDNFYNSVELSQKLFDLRRLYCGTLRKNRKGNPRVLTSLKLKKGDYYWYRKGQIYVSIWRDKRPELLIIEKGKKSGSGTHEIYKPSIKWFDSMDYIMKIINLKEKETLSNLEPNHASTSGNEDLDASDNRNKAVPTKVVRPPKTPKLKTKVSSERSEIQAAVNELKELNISLLNVSAPIPRELEDECDVIGRHVALQLKQLPPIDRIDATDEIQAILSRYRKSTRCARIMLIILYTPSDYSSECTPSKQPAANYQLVGPTISAHSTQLEQSSPSILHNGCTLLSQPVVFAAPYTGAVAVFCEASSLHSVTVRGDYWLLSYEYMGTVAVYCHISCSHCALIFYKMNDRDIEQYLASLEGGWLSEDDIEESDQEEEQVPEHYNREQVLNMLESDEEDTENPNDPEGDPPLVENEVIDIQNNDIRIPSGHTFTGLLDKRKLIWKKRSMEFDESKIKFQGSSDLGPELSELDTPYACFNYFFTEDFMKTIVEQTNLYATQQNPGKGTAFNLTDLRMFFGVLMYMSVQHFPILFIFLCQQPNRASKIIALVPNEHAPSDASENSESETEMHDDPRAYASSPLSSSAPSITSSLANLTISTSEDEEPNIDNNDVIPDSIVREIGESNYENVPSLSAIPSLPSTPMVPIAFSSPLSSRNTRSRKQASTVPAKKAKKGKKFQLSYKWKVAQFRHRATVEEDENGEYINLPEDVDSPLNKFILNVQQTAKSIQLSEEEFKDFLAIHIIMGIVVMPSYLDYWSDKFRYAKVGDIMSLKRYQQVRRYLHFVDNNMDDGDKYYKVRPVVEQIRQNCLKQQKKVTKFSIDEMMIASFVASEPVEKIRRYCKDAKCKIDVQCPQIVRQYNKHMGGVDLADMLISLYKTPFKSRRWYLAIFSQMLDICVNNAWLLYRRKHSSNAKGKIPLKAFRYEIYETLLKANRCAKRSKTETAKVSKPHVARPSSPVKYDNIGHFPSTMEEGRCRYCQKKSVVYCIKYNTRLCFRTTVRRSGCEDMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQZ4</accession>
    <name>A0A835GQZ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQZ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="477" mass="52603" checksum="1FA99DB12481FE2B" modified="2021-09-29" version="1" fragment="single">NYHPCLLVGCSVNNSKFPFINFVDNLKILKRPIEVIGELNNLTQNVSKRHCLNEVADIKNIARLTANGCSLKYAFFNASAAVTLCIRSYVKSSCSKDKPQSERSWWSIFFRNPASGYSSNVISLTRVVPRKRGFKVINSANIHPTLHMLIGNEYSFDSRSSPGARYQSVTTPGVYGQRENSNSNSRAIPRSATFRKPSRVKRMLFVSSCDIRHFSCCAEKILLLLRNVSMDIFHYQEYLLAFGAQRYRVSCDNVRVPQSNHFPRLLVGCSVNSECPSINSIDKFKIFKRPIKVIGKLSNRGMYPILISTSSSLSKAPTEELVWELKSSPESELEYSSSSSDSSDIKNISRSTTSGYSLKYACFNASAAVTFFIGSYAKSSCSKDKPQTESNSGSIILRNPPGGYSSNFISTSASLSKAPSEELVWELNSSPVSEPEYSSSSSDSSDVKNISRLTANGCSLKYACFNASAAVTLSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR27</accession>
    <name>A0A835GR27_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_002284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR27"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09501">
        <property type="entry name" value="SAM_SARM1-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09502">
        <property type="entry name" value="SAM_SARM1-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000056">
        <property type="entry name" value="Ectoderm-expressed 4, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000043">
        <property type="entry name" value="Sterile alpha and TIR motif-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000012">
        <property type="entry name" value="Sterile alpha and TIR motif-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="740"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="887"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9421844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120387" checksum="28C53F3E7390B5B6" modified="2021-09-29" version="1">MSKIPEFSLDGSNSIKQNGSAKDLVSVMENLKKGNLMSRQNQTLNTQATSSSTQQMVSSTTSSSATSSQRLQSSSQRLAHMANTERKASSMKSDLSELKSSISEMKTLSNTAAKNFSQRLRSSMENIVDQDDLADRNMPVIRDLSEMDDMGDISDMGELSSEGPLVTFPESDTPPPITEKPSLLSSSGAVVGSSTANELKYSAARMTSASSTRVVADGYSASRSASNSTKMRRLQHGDLQYAERSAASASHRLLQTEGLTAEQNAASLQEQRSLKAGEVTAQEANNMTTSSSRLQTEAFSAEKMAMASAQARQTVTSSGMFSHKEHSSVAHSNMTISSKNLSTKSTLHTSSQMSQLLNGAIKPGDEDLTNLTFDDLEKLNGSSNQKDVEMAIQKYSSRLNAFITSIKNNQMDMKNASMHFNKLNEMLRRAWAVPTYGHELGYSLCNTLRESGGLDILMGNCLEYNNPELQFSSAKLLEQCLTTENRAHVVQNGLEKVVNVACFCTKPTNSVDHARIGTGILEHLFKHSESTCGDVIKLGGLDAVLFECRKNDIETLRHCATALANLSLYGGAENQEAMIKRKVPMWLFPLAFHTDDNIKYYACLAIAVLVANKEIEAAVLKSGTLDLVEPFVTSHNPSEFARSNLAHAHGQSKNWLKRLVPVLSSKREEARNLAAFHFCMEAGIKKQQGNTEIFREIGAIESLKKVASCPNAVASKYAAQALRLIGEEVPHKLSQQVPLWSIEDVREWVKQIGFSEYATNFYESRVDGDLLLQISEENLKEDIGLQNGIKRKRFTRELQQLKKMADYTSRDTSSLNDFLQGIGPEYTIYTYSMLNAGVDKESIRGLSDEQLENECRIKNSIHRLRILNAIRAYECCLLSKGEENMEKNLDVFVSYRRSNGSQLASLLKVHLQLRGFTVFIDVERLEAGKFDNNLLQSIRQAKHFLLVLTPNALDRCKKDTDRKDWVHREIVAALQSQCNIVPIIDNFEWPKAEELPEDMRAVCHFNGVRWIHDYQDACVDKLESFLRGKSNLANRLDGQLRGRGDTQTPGTATIGRGPPNYQRMASCESRGNHEEIANLPWENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR34</accession>
    <name>A0A835GR34_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR34"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032690740" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="20821" checksum="907937ED85F57BE8" modified="2021-09-29" version="1" fragment="single">RSCTTILVVVVAVMALGLHQSVPKMGWLDRLVQYHKERFINKLRRTKPFTGTNSVPPNFNATLITKPEGFVDSNKWNFESVARLMFLLKSSEAAKPTHRALRRMLQPTRRIMMSIKESVQRFPGLQSGNNIYYDIEYSGEDEAEPKPQPLPEDQMVVVITNPVEARLPSSRITVQLLRLNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS10</accession>
    <name>A0A835GS10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="51"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9423433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="394" mass="44768" checksum="5781AD234A27875A" modified="2021-09-29" version="1">MNSVNIFEISEGVLDHPDSSLHTPREQDNSDWKHSAIAQLPDHLYRPLEDFELINKIDEGTYGAVYRATNKQTGEVVALKQIKSTKETEAFSVAAARRELELLMNLWHPNIVTGNAIALGSKSQEVFLIMEYIPYELKNYMETLRSNNKMFSAQQVKCLMSQLLTAVEYIHENFLFHRDLKTNNILLTRDGFLKVADFGMARELEFSLCPYTPGVVTLWYRAPELLLLSKEYSLPIDMWSVGCIFAELITLKPLFPGTTEMDQLKRIFMDLGTPSDVIWPGYSTLPLVRDITFDEYPPAGLRKKIDHELLSDCGLSLLQALLTYDPMERVTAADALKHAYFKEQPLAVKREMFFTSLESEDEEEYSGSDTGEEFSSHTSSSDGALDNDADVEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS40</accession>
    <name>A0A835GS40_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS40"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001291">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF45">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 12, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="156" mass="17039" checksum="EAF5E11B685FAE41" modified="2021-09-29" version="1">MVSTRTGIVSHYVRLQIVVPEAFILGSGEHHVDMGSVIHLICIVEKSPTPPQYVFWYHNDRMINYDATRGGITVETEPGARTQSRLTVRGATLKDSGNYTCSASNTEPASIHVFVSEGSNKMAAILRRNTSAIHGITTSGTCLLLLTSILLHFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSF3</accession>
    <name>A0A835GSF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_001770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF21">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="314"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9422566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="589" mass="66675" checksum="D7877336A0772FED" modified="2021-09-29" version="1">MNSLWHKLFLKKKLRTVDIGMPTDMKQHIHVTKNKETGRLEGLPEPWARVLSAQAKSIEENENPLAPVTVNLKETTHPVTYPAPGSKLSIKMSGRSSRGVFGKLFSKKTPREREERVTDIGMPTDVKQHIHVSKNSETGMLEGLPTSWLRLLNTQITPAEQNENPDAAIQAVKFHMYTIKKEKAPDEPFKPFLTDEAITEENKEIEKLLDHKNAHQSQESDLSIGQSSEEEVSTNDIYSQRQTMPAAPMKHNLKKKDAMMDLTAVVEDLTLIGNDPEESPILRKKELRYATLTDEEIYEELRKICNKDDPYVRFERIKQLGAGASGVVFVAIDSKDNSKVAIKDIDLTKQSKKELILNEINVLKGFNHKNLVNFLDAFLSYDHLWVAMELLDGGSLNYVVTEVVMKEGQIAAVCRETLQAIAFLHSKGTIHRDIKSDNVLLGMDGTVKVTDFGFCANIVGDEKRQTMVGTPYWMAPEVVTRKQYGKKVDVWSLGIMGIEMIEGEPPYMKESPLRALYLIAAVGRPKIPRWEKLTPHFQDFLDKCLQVDVDLRAAADELLRHPFLDCAMELRTLTPLIKAAHNVHRKNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSM2</accession>
    <name>A0A835GSM2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSM2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032276586" description="TM2 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20009" checksum="0B9211936ACE9873" modified="2021-09-29" version="1">MWVPRSTIVFLVMIPIILSEADPYSNEKYRPLGPLVKCNFLPLEFLDCDEPIDHKGNHTAREAVGHGCVKFGGVRYDQVEKTKVQCKALDGIECHGSRSFLRDGFPCVRYSGHYFTTTLIYSILLGFLGMDRFCLGQTGTAVGKLLTLGGLGIWWIVDVVLLITNSLHPEDGSNWNPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU57</accession>
    <name>A0A835GU57_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SERTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9423014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU57"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="2">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="170" mass="19474" checksum="B5D4DC57C0A376C1" modified="2021-09-29" version="1">MCPRFCYRMTPQEERESSRGAEIADAFEDDMFGPPRTEPAARPKLSMISARLRANEERKRVIEICSQKLENIEDPARDLRRSVCINNTYCRLSEEARREKEARRRRAREECDDSWVGKKARRAVEDECLALLDAIPELGDANLGCAQLARQMPRQDVPLLPPGLLTVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUN3</accession>
    <name>A0A835GUN3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein 1-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_000537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9424398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36844" checksum="DEF21B46090C514D" modified="2021-09-29" version="1">MGTVERAGDDHTSEVESGEEEEIVGGGELAQHLMKSGITRNEMLAAITNRIHVEAMASLPPNVRRRIRALRTLQKEFVDIEAKFYSEVHALECKYEKLYKPLFEKRALVVNGGYEPTDEECLNPWRDENEEEELARAVQSAAITDGSEEKKPEEKPAEPPMDPNVKGIPDFWYTIFKNVSMLCEMMQEHDEPILKCLEDIKVQMHEDPIGFTLEFHFAPNDYFTNTVLTKEYSMKCKPDEENPLEFEGPEIYSCKGCEINWKKGKNVTVKTIKKKQKHKSRGSVRTVTKSVQADSFFNFFSPPTMPDDPNSTLASDIQANTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXD8</accession>
    <name>A0A835KXD8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000913">
        <property type="protein sequence ID" value="KAF9404673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXD8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="139" mass="14223" checksum="75DD2D9945CC243B" modified="2021-09-29" version="1">MPPQTAPPGTHGPHPPQHGPQGHAPHASGNKDDGWHCLNGVYIGRQLNAKQLTVELSKSTLLVSSAGGSVGMGSHVASLSLDMLGANIAQRLNKQQQEPQGPHGPPGLGGQGPQGPPGDTGPPGTQVPVTWYGPQNQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXJ7</accession>
    <name>A0A835KXJ7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000523">
        <property type="protein sequence ID" value="KAF9406974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXJ7"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15583">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000005">
        <property type="entry name" value="Set1/Ash2 histone methyltransferase complex subunit ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="306"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="573" mass="64828" checksum="33F7CA2EE67A6F9E" modified="2021-09-29" version="1">MSSNNTDSYKKSTESENGSNNAHNNQSESQKPGENAERNKSNKTSNESQGNCYCGKDRNLNIAELLCASCNRWFHESCIGYQLGKLVPFMTNYLFICKNCSPTGLETFKKNQAPFPQMCLTAIANLRQETVKEGTNRLLFSKDREIIPYIDQYWEAMTTMPRRVTQSWYATVQRALIKDIQVLFTYEEDANQGPMFGLYNMELTAIKPNYEAMIKQGQLKVTDMGIATIPLAGNVKGRQGKRRPAVGGATDAGAPVGKKGRTADLGALKLPSHGYPTEHPFNKDGYRYILAEPDPHAPFRQEFDESNEWSGKPIPGWLYRSLCPGIVLLALHDRAPQLKISEDRLAVTGDKGYCMVRATHGVSRGSWYWEVCVEEMPEGAATRLGWGRRYANLQAPLGYDKFGYSWRSRKGTRFHESKGKHYSNGYGEGDTLGFLIVLPESATTKYTPNTYKDRPLVKFKSHLYYEDKDNIQESLNNLKPLPGSKIYYFKNGECQGEAFIDIYEGCYYPTVSLHKNVTVSVNFGPNFKHAPPSEYKYRPMSEKAEEAICEQTMADLLYLTENEGKLRLDNFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZA6</accession>
    <name>A0A835KZA6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000802">
        <property type="protein sequence ID" value="KAF9405148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZA6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032721643" description="Cuticle protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="18556" checksum="56649B55ADC4FFA4" modified="2021-09-29" version="1" fragment="single">IVALSAVLAVSAAGLLPAAHYSPAGAVSSQSIVRHDEVHPAAHVAHVAAPVHYAASPVHYAAAPVHYAAPVAKVIAPAQKVLVSAHAEEYAHPKYDFSYSVADGHTGDNKSQQESRDGDAVHGEYSVVEADGSVRRVQYTADDHNGFNAVVSNSAPAHHAPAPVAHAVHAAPVYLAHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZD2</accession>
    <name>A0A835KZD2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZD2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="130" mass="14701" checksum="7129263FC502F975" modified="2021-09-29" version="1">MNLKFDSEAFSILLWFKVVGWRDRENVEEYWNKILKMTDGTGEPMFPNLKEIIKVLLVLPFSNACVERVFSQLKLIKSDQRNRLNTDTIAALMATKAAVKNATTFEPSKALMHAKIKCSTDGDGDGEGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L031</accession>
    <name>A0A835L031_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_008204</name>
        <name evidence="1" type="ORF">HW555_011961</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000392">
        <property type="protein sequence ID" value="KAF9408292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000847">
        <property type="protein sequence ID" value="KAH9629913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L031"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032007">
        <property type="entry name" value="DUF4791"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16039">
        <property type="entry name" value="DUF4791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9629913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="21087" checksum="ED3E1B79CD373FF7" modified="2021-09-29" version="1">MGSDENNINASIAHIVLCCVAGRGVSKLHGKSFTHPGMHANFFIHGVLGFLHFQSKILDNDLNAAYQISLKATRYLALPCLNADLRRSDKTLSTLHLLSGVIPFALSLAGEDNIPLGNLMIACNIISLCHYSFETNREWGWYTAAASVVAYFLSPQIDKKIFYPLTLALMEYCAYRIFCIHYQPPPPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0A3</accession>
    <name>A0A835L0A3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000372">
        <property type="protein sequence ID" value="KAF9408624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0A3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="35035" checksum="46DA5FB2D1D27A0D" modified="2021-09-29" version="1">MRVAAGTRQMVTGYLILAIVTFIIYSVVWRGDCRLACYPEVFEDGGVGGRSGITGLRRRRSHPHDDCVCESCPCGIVAEIVKSCRPITQTYNSSVDAATQHYQNFANVLQTAGNHLATLMQCSTSSGRQVQVMMYLTTTSTIFDSSENFTLIAKPEFESKDELPTTSVSQASRFSEELVATFSGIATKISKSLDPDIAVVPISQNNLKAASASARVLFSVEKPSTSPKTFLKSIDEIPKIERKVQKQKSKKKITKEDEPACKSVATETIQRSVEPEQKPVPITDSLTSMMNCSKCVAEGKTCIGGCPNAKRKQQRMNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0M8</accession>
    <name>A0A835L0M8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000279">
        <property type="protein sequence ID" value="KAF9410084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0M8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9410084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34460" checksum="00C5997B4A0945AF" modified="2021-09-29" version="1" fragment="single">TPSVSQRSHRPKSVLGAHLMKIRTEPNERLASRLGMSRRSFERKLELARECLTNDFVPRHLGWDHISHATIMSTYIQNEINPMHYVLKSNDTFILDRGFRDSIPTIETWGYQAHMPPTKLRNESQLRTEEANKSRLVTIVRWVVEVINGWIKRDFKIFRQEYFNRAMTHMFVDIRIAAALLNSFREPLKDHPRANDIIQVLNERINMANSLGDYVTENNINRQRASFRTITSNDNELLQFPELTEDDLLLISLGSYQIKLARSYFSEHVRNGMYTIEICIGAIPDLARYNINISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0R8</accession>
    <name>A0A835L0R8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000271">
        <property type="protein sequence ID" value="KAF9410255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0R8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="373" mass="44263" checksum="E57573D0F0B72F6F" modified="2021-09-29" version="1">MLSAAKVRIHGMQDDNWVIKDKINQYRGLIKLYERDRKIHEGDLAKQKKRYSRDIRQLRKEITAKREELGVAVYGDRQFLRNAFQDHRRLQLTYMNSKADKVLESIHQENFNKRKQLDRIRYTKKKKMEKFRLAQLEAAEMRDRVLYEVGGKLPPEKKEQAVANYVQRANIKKNAALAIKVMYKKILDILKKDSSYFTVVLEALKLDCRAQSKCLMGATEMGQLAMEYLDDRKYEYNKLEREIKANMKERERTLKLARREVTYLTDSFPNLIRKEEATNLDDLYEDEDVSSYHSIHWELDEVMRICKRLQKATLVSSFDQILLRLKEQRYQSGRLMMALALNSEKRDMLLEDRKHAILMLDTLKNVGQERTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0U5</accession>
    <name>A0A835L0U5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000207">
        <property type="protein sequence ID" value="KAF9411979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0U5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF169">
        <property type="entry name" value="GH15759P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9411979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="401" mass="42490" checksum="544C5BF7A6CEC481" modified="2021-09-29" version="1" fragment="single">RERSAGRYGRAAAAALVHGAPAAPHATTASLPVHHKLPVPSVAMQSVVPLACFLSLIRPPAVQYENAILQLAPVDKAKCPYVHAGTDVSFQLYTRHNPTVPQRLALGDDELLFASSMDWAAPTVLYFHAFMEQPDDGSAVLVREAYMQRGDCNVIMVDAARLEAGPWYPAAALNTWFVGQYAARMLDYLAARGLRLNATHLVGHSLGAHAAGVAGAALRAGRVARITGLDPALPLFAGLPAAQRLDPGDADFVDVIHTDAGIFGYKHPLGHADFFPNGGASPQPGCELEVVLPQQLLLNKCAPPHRRRKRFLPALRRERAPAPAPPAWPALAVLGALLRGAPLVSVARVVSTRVTSRAGELAHVARETARYIGRDAPPPPAASLQVGGGWLGGGARLSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1I4</accession>
    <name>A0A835L1I4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000355">
        <property type="protein sequence ID" value="KAF9408887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1I4"/>
    <dbReference type="OrthoDB" id="6158299at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121305" checksum="233288F3ADF9A6D7" modified="2021-09-29" version="1">MHMDSSSEAMELRRELDAVRNALQQQSESVLKQRHQLVEAGHALAARDKKAAQERRLRQDQLALVLRSLVLLESRLTREQKQIHVALHQKEKIIKSQQEEIAKLKARKSYCSNCQQLLGFTSEQTNIETDPEFQSLESTDSRFQNTFVRSCSYRERNSPPVFQKNTRLSKSFQYQLPKSEIVYGNTSSSEEGNNASVSSKGTFIKNKQAFVRRDVFRRSRKYSGRKNNNKYGDNMQKGYNNNNQANSSSAEECIGMSYQVNHDDEITASQIANDIRKASMKIDQLIGEAAKKEIENTGSESEKTYSTKVERLHGIKRQGSDEIKANRQLFLNNVLSEEGNEKPWYCNVSDPEQEGDCMEQRPLMQNKSKSTEDLLGVGYNNGIHTEVISAKNEILCNNIMNNNERFSTRFDDKNNNMESKQLTTTDGNENWYASTSDADENPTNEIYKNNPVLECVNQILLQNSLDDSSNDNSKSSEAPSPKSSTKRVQFSTLNSISYDEKVRPNNTSNTLPRQDKRANKIVKFSLETASEHSYEVPNTAQGFQYEIQSLYSNEYEPIITKSADTKPTPIPRTVQAIEKPAVPKIRGSIVKNIAANIENRNVNNVVERKLDNELGSMKIFNKRKVPRTPPALPPKPKNLSAKWKAENTVKQMTEQLDSEAVAANQRVADVKTRKVGQVATVNNIEPDYCSISEINVPVVSNGKRELLLTQPTVEIHNEQYPVHAVSPRNSVAKVVSLPRIQNKISDKDIPKLPHVTEIIIPDEDDKSNDEQSRSFQQTADSYLTNFAMHPLQPKLDPRASIQMGNTVSSILSEINKGGKGGNKQINLTELDNQFNHGPEKNQCNNAEMHKAEYFDDIDKFDLSQNFEEFKIDDELGSIVAEEYRISSGSSDGSMSDVVTEHLTNVPDKDKQHNTNNKEDNETADNFLENNENALNKGLSKNAKLSNKPDLLSNIENLETESVRNSDIESSNSSGSNSGSYNTVKCEPRMVLNNNPELNAPKTKGTFDFFLETSGLSSKSIFTPSKQYVCVRPPCANHKNVLKPRDIKMRVKNTLTTNKINEKPMTTAIKYFEPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Q4</accession>
    <name>A0A835L1Q4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_010256</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000248">
        <property type="protein sequence ID" value="KAF9410739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Q4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin 13 N-terminal" evidence="13">
        <location>
            <begin position="145"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9410739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="369" mass="39646" checksum="27F577BCBE53064E" modified="2021-09-29" version="1">MSESQLNFNYGGNMAMGGNMPMPSNVGIPPPDQGMHYLPPGMHSASGVQANQPPPVPPRIDLNQALAQPSFANQMGNYGGMGSYGGMGSYGGMGSYGGMGSYGGMGMGMGMGAYGGYGGMGGYGMGGLGGMYGGYNRLMDNYETRFIQMAEERSRPAFESIQSLVNAVGSVAMMLEGTFFAMTSSFRAVLGVAENVGRLRSLFAQFWSTFAVVRTLNWIIRKLMVLIGIRTENEFQCGVHDCGINTARRTSPGPQGIRYSGWPVIMFFAVVAAAPYIVLKMMTRLNTTIQETLADPTTWQNPLKAIANYTFVATSPQELTIHENQIFHVAPKHLQQHLMPSGWLMATTDGKSAGPSASKLLQSDHPHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1Y4</accession>
    <name>A0A835L1Y4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_008206</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1Y4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9413628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="88" mass="9861" checksum="F196BAF558C52217" modified="2021-09-29" version="1">MASIKCPVCSKFVLPDDIECHLVMCLTRPRLSYNEDVLSDSKGECVICLEELSAGDTIARLPCLCIYHKGCIDQWFEVNRSCPEHPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2I7</accession>
    <name>A0A835L2I7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2I7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9414532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="242" mass="26820" checksum="D4AACD8B1B8DFEFB" modified="2021-09-29" version="1">MSQLAEVLSAQKSLEESFMKKMSALEAQIQTAGPTKDTVAKVAEEFRAFRELVISMLGLLRRQIGECSRQLDNIETRSRRKALIFQGIAETAGEDCTNVTLGVINNKLGLNFTKESIKVCHRLGQANSTHHRPILVRFASMDARMSVWRAKTGLRGSKVSVREFLTKLRQSVFGTARQHFGMRSCWTQEGAIFIKAPDGGRHKVTTLDELNPLLSKYPKAQGSSVGKRSPESTGEGLKVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2P9</accession>
    <name>A0A835L2P9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000195">
        <property type="protein sequence ID" value="KAF9412239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24890" checksum="FDEECB4C1C2828F3" modified="2021-09-29" version="1">MYSENISRFQNELSFITSWLPQHGTTFKITIVNKWFNLYLNSIRDVYGVHKVCESRDVSRPTSLRSALSQRVTQQNLVKMFRSVETAISFGGIDFAPKSLTSSCCYNGNRSAPYHLLFVTTVYSRPYSFECAKKNETSLRINKSFTRDRDDAYVWTTEQKIKVWTVGRNIFPIKKSIDRQKDNINQNIGMSPRREEARFALSNEGCRLCVPSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2S4</accession>
    <name>A0A835L2S4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2S4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032561717" evidence="2">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="376" mass="43349" checksum="424ACE343DD9C6FC" modified="2021-09-29" version="1">MFTTPQFALWILTLISIVSTLAESDTSNTNITTLYPVSNRNITRNDIHSRFSDTENKTNKEAIGNKTETPMNKTESNKTELKKNLPTQTWKIESSFVASNLTEVNNKTKEAKELLKDFKPSQHLGSFFDDENAEVIRTPAVGPVEKKPASGFLSPHKEVYYQHPSYNNIPKEIYYTHEEFPYKFEDTIYTKTKQGWQDSLDSKPTVEVPVKVPAGGLYKSPEAFKDKPQSVEEYGLEYHEDEKEHAMKKRVNPWQNLLRLVTAFIPVGLIISALTPSVITIHNVDDNLKPTSLPYRRSDIDAGVTNMAPISERCRRRLLCELHSEKNYVPPRTLPRRTMKQCYKIHCEDTEALWKMLRWLFTYNQETGDQRGRLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L300</accession>
    <name>A0A835L300_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposable element P transposase-like GTP-binding insertion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L300"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="3">
        <location>
            <begin position="335"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="827" mass="94467" checksum="D7360D4D0278B862" modified="2021-09-29" version="1">MLYLATGSSFAELQYGYKIGKSTISGIIKQDKTRQGGKLVKKGFTPQKLYKNEYKNICPGSTKFEKQQKTETYDRTLDREYEDTSQSTRTIPSCRLEPHYDAKVLDLNPSFANGSRIYNLDETSTTTVQRPHKVLAAKGRSVCKSSSFMFRLWGLIIIPPNENSRSTGAELGKQTTNSCNAIINKPSYVAISASVQNCEGTQDLQAQASSSTLLTLTPKRDKNLKRKYTEESVMSSSNASTPRKRKLQKIIVNKECLIKKQRLKIRRIQAQNRRLKKKFNKMQDVLNDLQKKFSLQDEDISVLKNLNVKIQELTNRMIAKSTGGGPSKQKYSPALHKDGNTIEWRFLEQLNNLQMKEGFHLANKLRYHHVHFQNNKMKVKLATQLFSLSVADAIDFCRDQLNLPSFKNSESTTFFLRIINNMFDIFNSRNTYEYNFKKALTESNAAMLLNYLDMATTYLSELRTEEGTLLTKSLRYIAHILIKKIDCDICIGALLSNSINEDHKFIVAKDKGESVIKIYTENLRNINKKMLMAKIMRHFVGSEIFKNIIYHQIGQYPTANHVTDLTKAIVEKYINLQAQVTTQASVAHQRNLELELRIWDIKSNTITGRNFLLSDVTAVWMHGQVTINKWKQRVALTTLTNNDEICVPCYLRAQRVLGSSQRSSTLVTPSTFRQSDTQPEQQTEVVPSTSRNLIDETSAEQISPATFTDDTAEDEEVTSAEQITLPTLRRAADTARRCMFLESNDSEKRQETQLDFQNPQSIDDHLFKYWFGRTKPEFNEVLVEEPQLNDGKMKNGFSALLCKMRTGGSDERITALFQIQEGLSRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L304</accession>
    <name>A0A835L304_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L304"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="34558" checksum="053E3CDDEAF0AFBE" modified="2021-09-29" version="1">MNSCLSTLFIYDNDTACWFGLVGITDCVCWSVGTWCGGLALDNETIDVASANFDDDDTSVDVTLPSSSTPNTKNISNDDSQIQEIRENSVHSPKIQFFNEAVKKRKQEMQLKQPALASCFERSSSFEVFYKVDKSIVKLHSVTCRPNQPTAFANSQAEANRQLVESLMASHAAGGFTATSSPTSSSTSKSGNMSKCTARFDGQNRDPEIVESFIDSIEMYKECALVNDDLALRGLPMLLHGEAACKYFLAVSALGANGDDDDANRAERACRPAGASRRCYVQQFGGKRYDNPIAQWCRSAAVDLAFAGAQINNIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3S1</accession>
    <name>A0A835L3S1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3S1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="125" mass="14240" checksum="4F8455C88E346A90" modified="2021-09-29" version="1">MYRLFFIDFDNKEAKIGPSRSGVSESSYVSMRQDFSVGSDPGRKGRALCWKSAGWFAIRHFRSDKVTLHGHKRMAPPSRPIGLSRDDFRYVRGKIQYPVGIFDQFTLVQNAPISPMVVVLKNTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L403</accession>
    <name>A0A835L403_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair endonuclease XPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_008921</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000183">
        <property type="protein sequence ID" value="KAF9412609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L403"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="12">
        <location>
            <begin position="635"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9412609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="884" mass="101839" checksum="13740D061E2CDFB9" modified="2021-09-29" version="1">MASSKNSVDTEEGQDIETKYPLLPFEKQIFVDSFEKDALVIMAKGINYNNIISNLLWIYKDPAHLVFVLNSSEHEEKYFNEKFNLSSLPNVGAEREKAYLEGGIHLVSTRILVVDLLKKRVPISHITGIIVLRAHTVLESCQEAFALRLYRQSNKTGFVKAFSNSPISFTFGYNQVEKVMRALFVTELFLWPRFHGSVIKNLKTRQADVVELHIPLTTNMSYIQTCLLDIINYTVKQLKSINRTLDMQEITTENCITKKFHKILQSQLDCVWHQLSTRTKEYIQDLKVLRSMTVNLLHDDAVSFHALVSKYSTPEYAKVNSGWILLESAEQLFRLARGRVFNHKQEFDPEPCPKWKCLSDLLLKEIPEEIKKNNANLNNTKILVLCQDNRTCSQLNNYLTMGPYKYLFYMAFRNDLTINSVSSKYTSLQKPVSKEEIPIPHEVEEGDNKEEFVNEIKSNYVLTLTQSAIQSDAKCEMHNESMFEPISQMDNLDFTQLETEKPIICIQTFKESGCNFSLERTLDTLRPEYVVLYHCDVAAVRQIELFECRKKIEEPKTKVYFMIHDKTVEEQAYLTSLKREKQAFELLIQTKSVMVVPSYQDGKTEEYFNLNVEHDDNTLDTRKAGGQNQAKEKPVVIVDMREFRSDLPALLHKKGINIEPVTIAIGDYILTPDICVERKSISDLIGSLNSGRLYTQCTQMCRNYSRPILLIEFDQNKPFNLQGHFVVSTDISGADIQQKLQLLTIHFPRLKLVWSPSPYATAELFYELKQGRKNPNVEEALALSGDNTAEDMHYERYNILVHDFVQKLPGVSSKNIARIMDRGISLDHLITLTQDELQAIIENKNEASTLYSILHVKPSPADANKDEKYGKKKFMGRKFPNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L435</accession>
    <name>A0A835L435_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_011951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L435"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9408314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="372" mass="42975" checksum="AF3A3FA1CA5F4941" modified="2021-09-29" version="1">MFRSPKDMVYQSKPKEIDEIITDDGFNCDLCNSGPYSTEFDVEIHRRSAHKWEIVKALKDDDVAICSICFYIQKDKESLVQHILTDHLCSSPDAKVINREIFVCDYCDHLFFNKDLLIAHIYHFHVAKEVKKVSNIRHNCPKCMKLISAKSTWFHLLSHGVINSRVCPICLKCFNRNAEVLNHVKTHKAHLRCNICGFVTMKELILSSHLKKHRKDRYFTGKADVSKYFVPCRLFPSTRKQSHVMKGIPMASEVRICVICRTVCLNNDEMLMHIYGDHAPDEKEKSKKYQCVCGEEFFNNVLLKHHIFKMRSGHNVFVGEPQESGEVKHMCTCGMEFPNTLMLKHHVMLIKSMHEPCDEPMASEDGQLGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L490</accession>
    <name>A0A835L490_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000131">
        <property type="protein sequence ID" value="KAF9414516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L490"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="44504" checksum="94C8DE9ED660AC71" modified="2021-09-29" version="1">MSIVSLTLFALDIPSSLYKFPNTQQNMQEQIPFLKKPNYSKKLIHSPVTNPSLINLQKPMPCKDPLQHERLRILNCKVYVCEHLSPDCKYLHAATRLKAKELKFKYVWVKYGRVYMRKDDRAGHILVKNVDFLNNITLNGIISRHTPLSTGNSCNYPTWFSPVLRQVLREKLKYHRLFKKYGNPRDYDTFSLLRSRCKKLIAEDYYVFVSSVESSLEHDIKNFWRFVNSKKDTNAIPQTMTYGNLVSSDQRGICELFSRYFGSVFDSSGVTADGLECRQAGMKNIHHTSLSVPERLVNSTSLCGNCVTMFESKSLGRGTQTLHPARDASCVYRSSQQQTDIIKQYEECLMDGHSVSSPIDTDLNAQLKTDKGPLTWSDNNQSEARLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4B0</accession>
    <name>A0A835L4B0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_008610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000171">
        <property type="protein sequence ID" value="KAF9413058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4B0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9413058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="36275" checksum="BA575FE503882D9A" modified="2021-09-29" version="1">MSPPTHSPNTSVTQAKTDSVNPASSSNTPSKGVNTQQRSKRPCPNYSPVNEFQDLKHVLLEMLSTWKEEQEELFIKFSTDQKNTLSKLTTELTELKQQNLAIKKTNEEIEKAVTFISKQYDDILKDVDLLKKENQAQKDYIQNLELKIQDCQHRSRPSSIEIRNVPAINNETVSDISSIITKVGSAVGMPLDAARIRDTYRLPGKEGTVRPIIAEFSSVQVKNELLSCVRKFNKANSNSGRLNTTLIGLAGDRRPVYVDEHLSGSSRKLFYLAREFAKQREYKYCWTSNGNIFIRKEEGAKLIHIKSEKTLQDLQLATNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4B1</accession>
    <name>A0A835L4B1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_016061</name>
        <name evidence="5" type="ORF">HW555_007529</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000129">
        <property type="protein sequence ID" value="KAF9414600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000816">
        <property type="protein sequence ID" value="KAH9630557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4B1"/>
    <dbReference type="SMR" id="A0A835L4B1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9630557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="134" mass="16101" checksum="C0B7168408D16465" modified="2021-09-29" version="1">MAIRPVYRPTIVKKRTKRFIRHQSDRYDKLKRNWRKPRGIDNRVRRRFKGQYLMPNIGYGSNKKTRHMLPNGFRKVLVHNVRELEILMMQNRKYCAEIAHGVSSKKRKTIVERAQQLSIRVTNSAARLRSQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Y4</accession>
    <name>A0A835L4Y4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ROP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Y4"/>
    <dbReference type="SMR" id="A0A835L4Y4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66538" checksum="2CDA5C2A5FAFF06B" modified="2021-09-29" version="1">MALKALVGQKIMNEVIRYRSKGKDKIEWRVLVVDQLSMRMVSACCKMHDISAEGITLVEDIHKKREPLCTMDGIYLITPSEKSVHALINDFSVGNRIMYRAAHVFFTEACPDARFDELSRSPVAKYIKTLKEINIAFIPYEQQVFSLDSPETFQCMYNPALAQTRNANMERIAEQIATLCATLGEYPSVRYRSDWERNVELAQLIQQKLDAYKADEPTMGEGPEKARSQLLVIDRGFDCVSPLLHELTLQAMAYDLLPIENDVYKYDSSGNMKEVLLDENDELWVELRHQHIAVVSTSVTKNLKKFTESKRMGGGDKQSMRDLSQMIKKMPQYQKELSKYATHLRLAEDCMKAYQGYVDKLCKVEQDLAMGTDAEGEKIKDHMRSIVPVLLDQAVINFNKMRIIALYIMSKNGISEENLNKLVTHAQLEPSDKQTLLNLANLGLNVVVDGNRKKQYQVPRKERITEQTYQMSRWTPVIKDIMEDAIEDKLDQRHFPFLAGRAQTSGYQAPTSVRYGHWHKDKAQQTIKNVPRLIVFVVGGVCFSEIRCAYEVTAALKNWEVIIGSSHILTPDNFLSDLSSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L567</accession>
    <name>A0A835L567_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000133">
        <property type="protein sequence ID" value="KAF9414463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L567"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="304"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="56828" checksum="5CCF42D151143ACF" modified="2021-09-29" version="1">MAIDNNRVLKGGWIPPGCHAYRQRSLIIHCEIDPKSIKISYNIDEESTRMGRVPESAPLPPELLDIPDNLLERSASDGTIEENFEEELARAPEVYTEISSLDLEESFAELNRTGLVEVVGDDEVGRRIIVVSACRLPPNKELLHDKLLRYLMFTLDKYVEQDYSVVYFHCGLTSKNKPPLSWLWRAYKAFDRKYKKNLKALYLVHPTNFIRIVWQMLKPAISVKFGRKMMYVNYLHELQQHLNLDKLCIPDAVLEYDKLLLSKNPRAAESARQNTVPAETSPIAKFNKKPKSSLSPPPTQQFGVSLAFIKENNVNMVGAIPPVVRQCVEFLSQPDALETEGIFRRSANMSVIKELQSACNRGEPLRFRNDPHNAAVLLKTFFRDLEEPLLTFDLYDEIMDFQNWSPRDKPRKVKILILERLPLDNYMLLKYVFQFLWKVQDRSCLNKMTTSNLAVVFGPNLAWPPNGQMSLLSIAPINNFTDFLLSHQESIFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5J6</accession>
    <name>A0A835L5J6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_005318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5J6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005983">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01293">
        <property type="entry name" value="Kv_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="313"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="654"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9417611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="692" mass="76860" checksum="95065606F47EBCA6" modified="2021-09-29" version="1">MQIAEAVERLRGMNTSWSHHRLCDLQRQAARLHHSRPSIPDTTKYQRNMLRKSCSTQLTKPESSHSIDDGIILNFSRFGPCRDASLDSDCGSPGGCVITVSAECNMTSENQWQNSTVDISSNADDDLCRPPSCQGSRMRRHEMQCKGAEVGGGKEGSQMSRSESTISRCTPHTPLGPPDSMSVDSNPMPTIYRCRAPIASLDCMDDFSANSQQMLDQEILSNNLLDVLSTCPLNEGIVVFSYDKCKAEPQSFAIQQTSLCAQSDRGNLYAAGEVNVSRHMSTYMGNHTTMPSVVTPGLRYKNLGKSGLRVPNIGLGIWAMLNEDCAEDVIMTALENGINLFDLSEAHCAKGEAELGRVLKKRNVRRTSVIITTKVYWSTKSDERGLSRKHIVESVKASLARLQVEYIDVVLLHKVDPVCPMEELVRAMNFVINQGWVMYWGTARWTPAEIMDAYSNCRQFNCITPIVEQTEYHMFCREKPELYMPELYHKIGVGMMAWSAITTGKGLGREEITGLFAKSRFNRKYSTFSWCEEDLAVPELPISSSKDQVTGEEPRTYGDKLRDLSNLANTLNCSMSQLAVAWCLKNESVNCLLLGATSVEQFKENIHALQIVPQLTPIMMIEIERLLANKPQRPPMVSTLAMRNQQNNNTVRVDMTGATTSGTGSPKPEGDVADAEASTPSKEPGRGFCEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6D8</accession>
    <name>A0A835L6D8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000030">
        <property type="protein sequence ID" value="KAF9420627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6D8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="124" mass="13944" checksum="BA9FB92DF8A70DEE" modified="2021-09-29" version="1">MNRMFERIKKINDASGSSMLKSNAKKSKKKMSKPNVRSEKKWKKLLRKTNPSSLETTNEAKARQNLTSPCTDNEVSGGDGPVTPNISRYFKKGPLRWIAVKQSNLSDSYLNIKINDSVASRPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6E6</accession>
    <name>A0A835L6E6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Regulating synaptic membrane exocytosis protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6E6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04031">
        <property type="entry name" value="C2A_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000188">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="434"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="578"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9419264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="134712" checksum="2C617BEDE2308E01" modified="2021-09-29" version="1">MRRKQDEVTVLEQTIRTRNEMHRAAGVELAATCHICLKTKFADGVGHSCHYCRVRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWIHKSAGQDSMLWRMENDLRGLPPQPDGSFDKRPKLERAHSAAEKENLPLQRSGSALRRQYSQQDQRCYGELEGLARTHPHLVHPRQKAAYGVVETGAPPTSQLLPLTPASHPLLPPRSSSSDDEVPECVSDENDEYRDRGQLEACAPVRHPHLRSANVAANNYYNLINHSPADYEAEARAQFDVPRTGPSGGRSFDSVTDCRWRARDDGEGAYLRPYAPEEGPRPDRAVYKSAYLWEDSSDNRRFTERRKKTVRFDGHEGAATFPRGGRDASGAPHDWAALRWEPERQTSQDSATKDSGIDTSSTFTSSEDSNRGDCPKFPLSWQVSADGTRMIGHMVLRKSVVEGSSHSSAAILGLKVVGGKLQPDGTRIAVVEKVKKGSIADLEGQLRIGDEVLQWNGVPLQGRSAEEVAAVVADSKHDLHVELVVSRPLTATRTPAVPWRTHKEVYTEVMGGCEKPSVLVTSPGSPDVHSRRRPTRYNHHNANVAGRIQLKIYFDVSATQLCVTVVSASGLTPRPDGSPRCPYAKIFLLPDKSEKSKRRTKTLANTLEPRWNQNFVYCGIRITDIKRRTLEVTVWDLNRYGPNDFLGEVLLDLDNIVMNHEPTWYTLKPHEEMGSFSRYREDEADGEHLSPPSTSTSRLSDSDTPSECDLRRHHSLSSLASSSSPPPPHDRMDMDGARSSRRDMSPAGRVRATGMNRERVMNEDRGDGSRLPTHAYAPRFQSRSATATPTTSPKKRQLPQIPHHQGGQRAVRAQVSADLEERKWIAPHHIGATLTYRSTPQGWERHYAGLSDSELAARSGGGAGAGNWAPRRRLSPDNAAQDSDLESVASVTSSAFSTQSERPRPTRMLRSLSNADVPPDEKADGSLSDTALGGAGELEPASDDVLLKAEPRDYFGPGMGKKSNSTSQLSATGRKRRLGFGKRGKNSFTVQRSEEVVPGEMRGGMSGVSRASSASSENDEDRWSPGMRGSGSDGGGLSDFIDGLGPGQLVGRQLLGAPTQGDVQLSMCYQKGFLEVEVIRARGLVSQPGRRTLPAPYIKVYLVSGKRCIAKAKTSTARRTLDPLYQQTLTFRENFKGCVLQVTVWGDYGRIEGKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L725</accession>
    <name>A0A835L725_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Wnt inhibitory factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_003395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000033">
        <property type="protein sequence ID" value="KAF9420334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L725"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000482">
        <property type="entry name" value="Shifted, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF32">
        <property type="entry name" value="WNT INHIBITORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WIF" evidence="11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9420334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35632" checksum="6D5B1C9AC8C0C598" modified="2021-09-29" version="1">MSISMQVFAIMNGHVVPYVLDPNFSNKLPVIPSEVGYVNFTWKSKKRYYYDFDILTSSDLTILKPPVLSIKTRGRVPKTSKEFSIILPCVGNNSGVATFEIGLVLKNGRGLPLKGTPLRLHLKKECAQRGVYLERTGPDPECDKKCANQGWCNNEKICQCPEGYMGQDCRTALCYPQCMNGGNCTAPGVCSCPPGYQGRNCEGGICAQKCLNGGKCIQKDTCECPKGYYGLRCEFSKCVIPCLNGGRCKGVNKCRCPVGLGGNHCEVGRRVGDCSCRGESCAGQHTCRHGRCVAGACVCEPGWRGRWCHRSTGWLCIWFISSLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L769</accession>
    <name>A0A835L769_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxiredoxin-5</fullName>
            <ecNumber evidence="9">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_004803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L769"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="189" mass="20213" checksum="9FF6BB4E03AA036F" modified="2021-09-29" version="1">MFPTGTTIFRLTTASSRRAIGRALHTSYIAMAPIKVGESLPVTDLFEDSPANKVNVCDLTAGKTVVLFAVPGAFTPGCSKTHLPGYVQNADKIKSEGVDEIVCVSVNDPYVMAAWGLQHNTKGKVRMLADPSGTFIKSLDLGINLPPLGGYRAKRFSMVIKDSKVDQLNVEPDGTGLSCSLADRLKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7H6</accession>
    <name>A0A835L7H6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7H6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF113">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13492" checksum="022B90FB8021FC1A" modified="2021-09-29" version="1">MKGGITSFSPMINNAVHVIMYSYYLLSAEGSPKMKAILIKYKKWLTIMQMIQFTFMLVYSAQVFLPSCPAPLGITILYFPNVIFVYYMFYNFFRQNYLKEQKMLNHSKNGVKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L881</accession>
    <name>A0A835L881_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">furin</fullName>
            <ecNumber evidence="15">3.4.21.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_003719</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.</text>
            <dbReference type="EC" id="3.4.21.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.75" evidence="15"/>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L881"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 17 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17 18" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="467"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9419886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="690" mass="76533" checksum="38C47735F49EED9E" modified="2021-09-29" version="1" fragment="single">QYGYQGVHNGLEHAREFVNEWTVEVEGGEEVAQLVALELGYVFGGKVRGFPDTYIFLKYEHEKQRRTPSHHTSALVKDRRVRWAEQLFSKSRVKRYAMPDPDEPLQRVKRLEESENLKKINEGHRGKTWFNDELWSHEWYLQDTRTLHNLPRLDLNVLPVYEMGYNGNGVRVSVLDDGIEHNHTDLRANYDPDISWDSNDDDADPSPRYEDIKLNSHGTRCAGEIAMTANNLKCGVGVAWGAKVGGVRMLDGRITDRIEGEAIGYALDKVDIYSASWGPNDDGRTVEGPGRLANEAFKRGVTEGRGGKGAIYVWANGNGGGHGDNCNCDGYSSSIYTISIGSASQHGLFPWYGEICSSTLAAAYSSGAYKDQKIATTDTGDSCTLGHTGTSAAAPLAAGIIALALSANQNLTWRDVQHLIVWTSEYAPLSANPGWQINGAGLYFDVRFGFGLLNAGALVKMALNWTTVPRDYVCRVNSAPIEEENTRLWSGHHVEVPISVENDCLVNFVEHVEVSINVKYSRRGALEIYLVSPQGTQVQLLSPRRKDTSTTGFVNWPLMSVATWGENPKGVWKVIVVDNTDEKNAGHVGPVGLTIHGTKTMPAHMKNGSRIYNDNYNYQEAFEYFDNVDKEVADVVSNTVTDDEVVAMLPGDHKSQAVVDIHDIDSTVLAEVEKELQRINHRRVYSDIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8I3</accession>
    <name>A0A835L8I3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8I3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="440" mass="48314" checksum="52BD35B56430948E" modified="2021-09-29" version="1">MCYVDSGGGGSAEVGGHTRLLVLNDSTVIKPLNIRELHFYQNIPEDIQNFVPRYKGVMQASNTGGPKLDKRYSPCFRDENGRKQSLGGKRKRDDVFKFKVHRNGNASEVLKSIAHMDNSNKQYFLMMENITSSYRRPCVLDLKMGTRQHGDDATAEKRSKQIAKCAASTSATLGVRLCGMQVYVPETGACVRRDKYWGRALSESGLREALRDFFAAGAGLRARVVRQVLRDLDALRRAIAKQTSYSSLLIVYEGDVETALAEEARGVTSEYDADASSSSAELAPSPGHFDMSTLHDEISTEPGAREPFRPHSEETMGGYEDGEVAGHSPRRQPPSPDSADSWMAYSSTSSESWRGEAEAEPEPGSGKRARTWAPRPARPPPDERVDIRMIDFAHTAYAGAAAESPLATSTPHHGPDCGFLTGIDSLKRLLTEILPPQPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9U3</accession>
    <name>A0A835L9U3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9U3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="408" mass="47167" checksum="7548D80A300D1B85" modified="2021-09-29" version="1">MQLFLRLFSKMALYQTFIIIYVLKIVFYPCCALAYPESEMNYYKNSTHRVTRSIDDVDHSRDRNKYILMPKYSIYLMGFTILFMFIAIIALSVALYWAIKKRSSFGVNDNIPQYVRQESNTVIPLYNNSTYDEQNKNNGSTLTVNSGIIEISEPRISEPESPTRVDDSKIVFTRKPIKPIVPVMPRGQMDAICQEVLRRVQKSDSASFRDLNELLNGNDKKDEKEGEKCETVDEAENEKKNEEKADPKFDLKQLKTPESNITPELLSKLNARSQQLQNQIEDEMNKAAKQENPIDKPHEYHDKLKSDINNDVHIEIDYINVNKMDDSSSSETEYDTVPTPIRFRHSGPEAENLNIEDIPVYDLPPRRSHDGNTGNIVQIDKDTEYMMPLSKDKTDSCYINAKRNSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA10</accession>
    <name>A0A835LA10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000016">
        <property type="protein sequence ID" value="KAF9422478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LA10"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032394011" description="Cuticular protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31903" checksum="4424A912A9A83045" modified="2021-09-29" version="1">MKLLLIFAAILAFSLAEEKKKEEVLNDSEAEASATIELMKEGVDLNAAASSYNSYVPPSQRPPHWNVKPIQPIQTSVPVQNDYYEHHNHQWSTPVYHPPTTTTPVSVIKNEQYYGENGHYKYEYQIADGTHVGEEGYFTDPKQTEESLVKKGWYSYLGADGKKYLVTYWADKTGFHAYGDHLPTPPPPYNPNKQPEVDSNRPLYDYPTQTQAPAVFYPTQPALVPVKPIYVPPQPTLPPVQQPTYAPQPSYPPQNYYPPQQTYYPPQQNYYPQQQQNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LAD8</accession>
    <name>A0A835LAD8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LAD8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="38878" checksum="B4191EF1346E7292" modified="2021-09-29" version="1">MTEMTKSLETALTSDLFWESINILLSKPHVINKRLWGSKIWFRNTCKPKSTPFKLPATLHLLSDLVATDNVEQYKIQILNELDVDNILPNTSDNEDQVEVLLMELLPKNYSDKQGYQVACLWKDKSSITFYDVTPLNQEQKLCPDFSYTIQLNTNHILLTAISDENSKSFKWLSNTLLPQLIKWGTESESSTKSNMCNESLSLVSQTKYYEKYNDLKVKYGKEMVKIWPECTDASKFVYEDVAIAAYLLLLWEREEPRSSKSFVDLGCGNGLLVYILSQEGHTGVGIDVRKRNIWDMYPPGVVLQTQIDLRFLALKEYALLVTIGYIYKKNIHNTAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1C2</accession>
    <name>A0A835G1C2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Choloylglycine hydrolase/NAAA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001078">
        <property type="protein sequence ID" value="KAF9404121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1C2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00542">
        <property type="entry name" value="Ntn_PVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052193">
        <property type="entry name" value="Peptidase_C59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527">
        <property type="entry name" value="CHOLOYLGLYCINE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527:SF2">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="394" mass="44278" checksum="721D64656D24D235" modified="2021-09-29" version="1">MCTSIFTTTKDNKHLLARTMDFSFPLNPNVLYLPREYEWTSEADKEKHQSKYGLLGAGRLLGTSYFVADGVNEHGLAIAELYLPNKAVYQKELNDEKINLAPHEFITWALGKFKSISDLKTELSKVNLFEVPAPLIDTVTPLHWILTDTTGACMVIEPTGKMLHLKENPIGVMTNTPLLEWHIENLSNYLNVRPKQYDPVEFGEYTSHAFSQGTGTLGLPGGYTPPERFVRATFFKENIDQAAVEAEAVTNAVRILATVQIPKGIVVTSEGKEDYSQYLGMMCNESKTYYYTDYNNTRISKVVLTDELLERKTPKVFVMKKTEDINILNQESVTPEEKISDIKQTGETGANILDILRQELVLGVKAAQDGSLSDDAHQTIDQTIEQLKMLKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1E3</accession>
    <name>A0A835G1E3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Uncharacterized sensor-like histidine kinase ycf26</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_014203</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000900">
        <property type="protein sequence ID" value="KAF9404721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1E3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000001">
        <property type="entry name" value="Two-component sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050398">
        <property type="entry name" value="HssS/ArlS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45528">
        <property type="entry name" value="SENSOR HISTIDINE KINASE CPXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45528:SF1">
        <property type="entry name" value="SENSOR HISTIDINE KINASE CPXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="18">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="206"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9404721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="429" mass="49023" checksum="53A997F28CB5F581" modified="2021-09-29" version="1">MTDQDVLNNSFRLFEGVLSEQDVQFVFYDQNMDVQYPVDGETLDDSIVKKNWAKLMQGQQVYATTEQDIYGNKHMSSYVMMPVTLTNTQSNENTIVGALIITQPAKNVSDSVNAITGNLFKGFIISSIVGLILSYFFASFQVKRINRMRKATKEITSGNFDVKLVTHDKDEFDDLAEDFNKMAESLKESREEIDRQEDRRRQFMADASHEMRTPLTTINGLLEGLEYNAIPEDQRKNAIKLMQNETSRLIRLVNENLDYEKIRTNQISIVVKKFDATQTLKNILTQLEAKAESANDQLILEADQPIDVYADYDRFVQIMVNIIQNAIQFTQDGEIRIRIQKGYLETIITISDTGIGMSEEQVQNIWDRYYKVDPSRKNTKYGESGLGLSIVEQLVRLHKGKISVNSEQSKGTSFTISFPDVEIQGSNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3K0</accession>
    <name>A0A835G3K0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative hemin import ATP-binding protein HrtA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_014418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (HrtA), two transmembrane proteins (HrtB) and a solute-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. HrtA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001024">
        <property type="protein sequence ID" value="KAF9404286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3K0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF666">
        <property type="entry name" value="HEMIN IMPORT ATP-BINDING PROTEIN HRTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="146"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9404286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="366" mass="40299" checksum="E78259A94E537D40" modified="2021-09-29" version="1" fragment="single">LSYGLAEDNRTAVDKWQADGIVLSDEANTNINMSMIPIKSKDQVEAKEKAVLGQTAGVIQLDKKGSEKINVSFFGINKNEFLMPNIVEGKAFTNENEAVVDKSLNKENGIQLGDTIKLASNDKKIKVVGFTDNAKFNVSPVLLKAIEFLTVDKQFLDGDTTIEALKPTNVSVEKGQFVAVIGPSGSGKSTFLTLAGGLQTPTNGEVKINDEAFSQENEKQRSKIRFAEIGFILQASNLVPFLTVEKQLYLVDKVQKAKADVDKVNELLTQLGIEHLKKKYPDEISGGERQRVAIARALYNDPSIILADEPTASLDSDRAFEVVKILAKETKEKNKATIMVTHDQRLIDYCDEVFIMKDGVLEKQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4F6</accession>
    <name>A0A835G4F6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Catenin alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4F6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64888" checksum="7C06FA31FDB02325" modified="2021-09-29" version="1">MATMTDQYGTTGTLTLKWDPRNLEIRTMSVERTLEPLVLQVTTLVNSKDRDAKKKRPGKSKRASALVATVERATEIFIERGQTIAYENPEITQQMLTAVEEVRKAGAAMSLAAREFSEEPCASQVRGGMVRAARALLCAVTRLLILADMVDVHLLLNKLNTVENDLDKLKSASSQSELLESARQFGRSASELAAQAAKRQRELKEPRMKDELAAARAVLKKHSTMLLTASKVYVRHPELAAAKANRDYVLRAVCSAVDSISAVAKGQPIPVVGGNRPVEGPGELAQALDDFDERMVMEPLAYSELRTRPSLEERLESIISGAALMADSSCTRDERRERIVAECNAVRQALQDLLHEYMANTGKPEQSAGLERAIENMCRKTRDLRRQLRKAVVDHTNVPLLVLMEAARNGNEKEVEEYALVFTEHANKLVEVANLVCSMSNNEDGVKMVRHAAEHIESLCPQVTARPRSRVAQENAAAFARAWELAVKLLTDAVDDITTIDDFLAVSENHILEDVNKCVVALQEGDPDSLERTAGAIRGRASRVCSVVTQEMDNYEPCIYTKRVLEAVTVLRDQEEIYKDKKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4L3</accession>
    <name>A0A835G4L3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000699">
        <property type="protein sequence ID" value="KAF9405683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1776"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1817"/>
            <end position="1827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9405683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1827" mass="206989" checksum="806A7BD23BD73EBD" modified="2021-09-29" version="1">MLVKWCRIIKNNEIKMLTRKILVMPFWQIKKYKENKPRNDLVFSSEYTVAQVFTREEEGMLREHLVKSSKMNYRLTYKQARSLAYEYATALKKCPIKWTEKKKHEYNGSKEVTNRPVPTTSSDAFSDVLQTTSAVADTDCEEVEQEINFEDSPPATALYIPVSPPVSPSIIYSTSAQLIVSDVGPSLSLPEAETISSITEFNTPPMTSAVSPPSTVNVPEADLTETWIAPSVAASTVVITPEAVKPFPRALPRKESNKGRKKGKSRILIDTPEKDEIQKAYLERQARLKKSQEKLLFQAEPQPGPSYCQVQVLKDVTNRYTEPKPTSKKSIQPLPGTSHVLLEENKVHSEINTLSRDITMRPEKNNIRHTTVNFDSIVKNGVSTASCSRAKDASSSDSSEDDNEINITDNTEYSSEPRSLDSSFERLNILENDEFLPEDIIPSTPAISEVLATYNPPQHLPALQSISSVLSMSPSPVAATIVKETRSKKKLTTNLPHSLTKKKKAFLRKPLEFKWEGGKFKHSATLEEITFTQFGSESKSPSDYFADFFSEDVINIIIENTNLYAVQRNLKSINLTRDELLDFIAINLLMGVVKMPSYRDYWKKDLRYNLIADVMSLKRYEQIRQFLHFVDNSQQNGDRYFKVRPILEASIKHKPAIVYFDNFFSSLELINLLRGEYGIFSLGTIRANRLRGCQEKLPSDKDLLKKGRGSSKQSVVIWHDNKSVILASSYVDSFPMETIRRYSKETKSKIDIPCPQIVKHYNSHMGGVDLCDMLISLYRTNYKTKRWYMALFSQVLDICVNNAWIMYRKDSARYNKVPNSLKIFRIMIYYELLSKHRTPAAMSTSLEKTQQAKFQKIQKPSEPRPTDAIRCDNIGHMPDYTTAPGRCKFCKKGMTNVICCKCNLRLCFVKNHFNFNMVRTYQRKFTNSRNGKNHSPYLSYCKEDLQNAIGEIQNGSLKLIEAANKYKIPKSTLSRKCQNINCTQEKAGHPTLFSKDEEMAFIKYIQILSNWGFPLDSTDLRVFAQKYLNKLGKTVYSLKDNMPGVDWARNFMIRHKAEISNRNASNITSVRAKISPAIIDEFFSHYDNTIEGVSPDCIINYYPASVLTSEAAVTAGLISKMDMLFDSVNSDSSDLRRGKIHATNLKETTPHLQLTLNAIELLWNYLRNKHTNIQSLGHPQTTAGPLGKFLWLHSGANYNPTAGQFIAALKTSILSNLAHLNTGNCESDYCESIIDNYKEVLTKSTNICTDDTISIYNISYSSDFSEKIENLCHAEPSIGKAQACAFVCGFLIKRLDYTCTSCLNILISKENSSVGHLFIQFKEYNSEKQSVNYPHINIINYVESCASVANKMFVDIGHEKHVHLYSNKEPSSLVNNSPYRSELNVAEFAVPVEDTPNEPHTVPPFDKKANTSTQYTHKTQPIQVFEKFFTDYIIEIIVHQTNTYARQKNSKNWSPVACAEIKVYLGVLILIGLNPLPDMEFCNLMNALYEKGIYAVGTVRSDRKDLPSILKISQPKALKLEKHQFASVSAGPITAIKWHDTRDVSVLITAHHPREVMYVKRTQKDGSRQDIHCPKAIASYTRTMGGVDHFDHFHIVKPRHTQSNFQDLDAGSDNNVTQNSDTVEIPEIDQVETPEMDLIEEVMENQEPVSESVNAGYLASELQLYNYEVTGNGEMILLNTSDRLENVLLEQSQVCTLHLTPNRAVKPSHNSENIVESIVEVIPDAESPTILNSYDFEIGNFHVVEETRTDTNSPTILNSYDFNLEPELSTSLVVATSSRTRDDDNYDPIQTSCSSEDDDSGMIEANSTGRKTKKRKGLADAEHWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G536</accession>
    <name>A0A835G536_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mutant cadherin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000446">
        <property type="protein sequence ID" value="KAF9407674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G536"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47031" checksum="80939436DD8C8DC0" modified="2021-09-29" version="1">MVMFMSMYRKLEATQPYTGEGARVPALLECNPRISNTDAMRCHFVLSDCPAIAMSAELNGTKRHTRYTLYILDELLAYIQNKISIADEASLVQICASTFTSEQIQNSKSLLIESLSSEVRSTVRKGKGKDNRVLYDIIAIFKTTEPDVLPVFVARELEKLPPITFDHLDVSKLLKDLLIVQAEINNIKSTYVTQGELQSWKEECEKKCLSSSAANISSMNTTGGTENGCSNTCGGEENANCSKFASITTNSQNRYPKRVINTVEGTLEKCYKETVTCLKDNGESDASSVPLSTTSNNLSDQLSKNMGQASQSYASIAAQMNDGFTLVKNKNRKCPVYNLLVDDREPNFVHVVVLAFSLELVGAILPLLLYQVSISSCEQHTIVKPPLAWPTCLQWRSSEIFPKCGDGFTKRMIERHPAETQINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5E9</accession>
    <name>A0A835G5E9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/potassium-transporting ATPase subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5E9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF46">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34139" checksum="FE774712962519B2" modified="2021-09-29" version="1">MASKTNGVEEWVRAPPPPGTCLSRFTNAIYNHEENSFLGRTPKRWGIVLTFYLVFYAVLGLMFALCMGGLYLTLEPNRPTYLLEESLIGANPGVASRPLYETAVLKYSVENSSEYQLYVDQLNEFFNYYSSERWYTTQKECRAEDQYGFPDNPCIFVKVNKIIDWKPEYYEASDLPADMPEDLVEHIQGLDPSKQKQVWISCEEEKANDTKLEYPWGRGMPKEYYPYVYGNKEYKSPLVAVRLSHPAHNQNVVIRCRAWAKNIIYNKSLKEPSGYTRFQLYIEGNESGNSTEVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5N6</accession>
    <name>A0A835G5N6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000448">
        <property type="protein sequence ID" value="KAF9407663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5N6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="72" mass="7923" checksum="892F323D1395162D" modified="2021-09-29" version="1">MHKGGFCAPIPRRPAKQKVTWGSPQRTLVARAVPRLGAPRRSSMPPGESSAKPSRPKKCRRWPDVHASDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G618</accession>
    <name>A0A835G618_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000396">
        <property type="protein sequence ID" value="KAF9408238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G618"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9408238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="11760" checksum="0BDE1C845C56D104" modified="2021-09-29" version="1">MDPINNTVAGLMDLFNKRMAQFEAQLQREPAEPSNTSNLAAEFFSFRVFITQAVTTLQQQVELLARNIDSMEMRGRRGILLLHGVPEKREEDAAQLVVDIVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6J1</accession>
    <name>A0A835G6J1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6J1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="596" mass="64182" checksum="762148D27635E7BA" modified="2021-09-29" version="1">MDNLLYGLFLSAIYSRAIYLCDNLGNKLGLHDDVWFFIVVVVQNILFKVHRRNYTKLFDLTHEEICVGRNMGTFYRKIIICSQVISTMNTVVQTAGLEDLEKDHLLIASAANNIVAPPSGTMRHDLWLCVACLASSLAAPAPSQGPQLYLDIIDMAAISRMTPQQLEALAEGLAAEEIMRTKRSSAQALTSVVSKASSGIQSKVGLLGQASAFIASASSKSGGHGEEGHGYNYEPHHEDEKYDYWGLKKSILYTLFQAVKAITGGVTILKGQLIKGGGALAATLGKVISSKGDAVSNLGKKIVSSAALSHKKPHCDDCSVRTPTNESLGIRPPTAYGTPTAPAHFTAPSVPTGYAAHKYPSQLDGRGKLNGVHAGLVILTPLGDPSYGAPSYAPAYPTSYAEDPIAPAAPVAYQPPPPPQPIPSFKPMSWGAVNSYGQPAAPDSYIDYDPRTPAHGYVDYATPKRSVAPTVKKGLTPEKIQKITTNLKKVTAYINNQQKRSSEEFKLTDLEAYREMLAKGEIPFLPTPVVSDNEIGVLPAEVLDPLPSVATTTSTTTSTTISTTSTTTAKPQTSTEQTRRQDFKYYLRGNKIVQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6L6</accession>
    <name>A0A835G6L6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCNA-associated factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PCNA-associated factor of 15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PCNA-clamp-associated factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_011957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000391">
        <property type="protein sequence ID" value="KAF9408320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6L6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040444">
        <property type="entry name" value="PCNA-AF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031444">
        <property type="entry name" value="PCNA-AF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15679">
        <property type="entry name" value="PCNA-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15679:SF8">
        <property type="entry name" value="PCNA-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15715">
        <property type="entry name" value="PAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA-associated factor histone-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="180" mass="19651" checksum="B04C57340F52EA47" modified="2021-09-29" version="1">MARTKASVGSKVSAGKSSKARCCVAPTPSSSGMSSVSSDKGSKGYSGGNPVCPRETPKWQKPITKFFITKEDSRDQEVNVDDEETAGTSNSKPKDKPNVIHSDSEEDVLVEKAKNNVLDESLDLEPLNGEDSHKIEEYYPKGSKGKGVGKKTKGKENKVDFKRLREEEDVENSSKRIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G791</accession>
    <name>A0A835G791_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal peptide peptidase-like 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000442">
        <property type="protein sequence ID" value="KAF9407731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G791"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43646" checksum="0BCB5801B504E529" modified="2021-09-29" version="1">MAQVGANMEYQEYKWAYSIMDSSKVSACLISMLLIVYGSFRSLNMEREARERAEREREATLLGGKPATTSSNSNSNVQTLNTMQALCFPLGSSVALLIMFFFFDSMQTLVAICTAIIACAALAFLLTPLCQYVAGGARGAVCGRYSAPELAAALLAAAIVAVWVLTGHWLLMDAMGMGLCVTFIALIRLPSLKVSTLLLTGLLLYDVFWVFFSSYIFTTNVMVKVATRPAENPMNVVARRLQLGGAMRDAPKLSLPAKLVVGYKVEKDLHVASKFIMYYFLIGLGDIVMPGLLLCFVLRYDAYKKATLVCQMGQVPGPRSMGSRLTYFHCSLLGYFLGLLTATVSAEVFKAAQPALLYLVPFTLLPLLTMAYVKGDLRRMWSEPFIAPPTGKSGADFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7N2</accession>
    <name>A0A835G7N2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HF086_006745</name>
        <name evidence="12" type="ORF">HW555_012141</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000411">
        <property type="protein sequence ID" value="KAF9408050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000774">
        <property type="protein sequence ID" value="KAH9631167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7N2"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01226">
        <property type="entry name" value="PH_RalBD_exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9408050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9631167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="683" mass="78156" checksum="706CF9248FF4F890" modified="2021-09-29" version="1">MSDINMEKFAVSDFAPERYVKELAKSCVGGEELQQQKDKIQSLADETANALKKNVYENYMQFIETATEISHLEAEMYKLSHLLSEQRTVLTTLSHASILGNENAISRESLDNHDVEAERAEEQRKNKLNLISEKVEGCMNLLDVPDRTVLHEGDLLEIDAEENTAIQRMHVYLFNDCLMLTSWISNRRGPNRYKFQASYPISTLAVVNVRDLGSVKQAFKVLAFPDTRVFQCNSFAIKKDWLDKFDIAKKLHIEKETSKQKKKDSQDKPKPELLESPSLSVEELPSPQLAPLPEWLADVTEELDVLIVERHFQKTYELMVSAQKALDTEEHKNHPSRSDILKRIEQKQKVLIEILLKELDVNHNWSPRGGLQSSRQPVLILNKFNMTSQSCELFLAICSHTVKVHVKGVQLEGSINSYVKQVGEVFFCSLSDALTEFITLFPKNKISAFVVWASTQLRMLMSQIIKQVFTPQCALDSVLDCVQSLRDQCLLFCEFGLDLRFQMNSCLRAPIVKALREYREKVMDSMKNKVSEDKWTPVNMHTKAGVGKFLTQMESLGLILAKYIINETWVDLSSSTIWFAQSVITIQKVGLQLVTKDMMDVLDECIYAVFNSRLKLSIGNDSSYAQKNFKFILDTVMPLMLRCYKEEVGYDNEKLVSLAKKFGVYIPPPKKSNITKYTSNEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7X2</accession>
    <name>A0A835G7X2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000326">
        <property type="protein sequence ID" value="KAF9409276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7X2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19383" checksum="B8CB7FD575D24BC7" modified="2021-09-29" version="1">MDIDMIDLMDLEDLDMLETSRRSNRRRYRRNPFESSEEDFRYKYRFTKRFGAKIVDILREDLCHDPRGCPLSPELQVVCALRNWARHEIQDDTADLHGVSQPVVSKSCKMVAHSLAMMSRRFIKMPSSLDAQQQTMRKFRSIANFPTVIGAIRLYSYKSEENQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W6</accession>
    <name>A0A835G9W6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF106">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9411346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="503" mass="57046" checksum="825FCF8615D16F8D" modified="2021-09-29" version="1">MMFDPPDYPYKELSESYDPDDLLFTNVTDSNEILSSGNKNSQDVTTIMNSVENHLTFHSNDSGRYFNIENSSFFQENNLNMVQNTELYIVQSDNMFNYEPTLLDENTVNQFLLPLPESSENNQTSESTGPDLLALHSCVICHEIFTTEADLLDHTISLHTSDNSVEQLENTLLPTTDHDRIETKNVQGPTQNNENFETEWLVCRMCERVLSTALEVEPTGKNNYAASPPMVRVTWHLASCILCMFAISVAVSSLMETLSTNIDSPASLKIRIITMRHQNDNCNLDTTAHGPIVCYACDICGKQYGSTEDLKAHSLECHKPRASRRSYTNSGNTKMWNCGSCNQLFATARELYRHKRGEDRPPGAPLMAYVCEECDKVLGSMCALHTHKKMHKVTKPGYPCRVCGRRFNQSGHLAIHMRMHTGERPYPCDLCPKAFKVKVERDDHRRTHTGEKPFACTACPKTFTAAARLREHARIHTDQRRSGDMWKHKRTLHGVQAVTDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA60</accession>
    <name>A0A835GA60_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000252">
        <property type="protein sequence ID" value="KAF9410679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA60"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="595" mass="65263" checksum="9B52E0A217AE9503" modified="2021-09-29" version="1">MDSVYDFIVVGGGSAGSVVAARLSEVPEWRVLLLEAGFDEPTGAQVPSMFLNFIGSSIDWGYQTEPEPAACLGETDRKCYWPRGKVLGGTSVMNGMMYMRGSRKDYDSWAAAGNEGWSYEEVLPYFLKSEDNKQVKEMDQGYHATGGPLTVAQFPYHPPLSYSLVKAGEELGYKQRDLNGIHHTGFSIAQTTNRNGSRLSVARAFLRPAKNRPNLHVMLNATVTRVLINQTTRQAYAVEVRNSFGGTEVIFANNEIILSAGAVASPQILQLSGVGDPKVLSRAGVKLVHNLPGVGRNLHNHVAHFLNFQVNDNNTTPLNWATAMEYLLFRDGLMSGTGISEVTAFINTKYSDPAEDNPDIQLFFGGFLADCAKTGMVGERLDNGSRSIQIIPTVLHPKSRGRLEIRSADPFEYPKIYANYLTHPDDVKTLVEGIKFSLKLAETKALKRYGVKLDKTPVKGCEKFKFGCDAYWECAVRMQTAPENHQAGSCKMGPRGDPSAVVDNLLQVQGIDRLRVADASVMPAVTSGNTNAPTIMIGERVSDFIKQRWLGITNVSMKGDDTENDRAPYPVSHGGLSNVLQASDSQPQLAWQQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB09</accession>
    <name>A0A835GB09_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_010551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000267">
        <property type="protein sequence ID" value="KAF9410334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB09"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9410334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="508" mass="56196" checksum="B9FA5F0777C339CF" modified="2021-09-29" version="1">MVKNDIKKHYDKEKPQEWHVSEKKKADDEPIYYFYHSGTVKQYAAGLAGALGALAAGSNLGWSAPIMVKLDANYGGYGFPVSKAQGYWMASVIALGAACSCYPIGFIMDAVGRKKTLLSLTIPFLVGWGFITFAKCANTLIAGRFITGLAGGALSVTAPAYASEVSQKKIRGSIGSLFQLMLSLGILLAVVAHGHVNTFVFNCMCACIPLIFCSIFIFMPESPKYLVMKGRYEDARAALVRLRGTKYDVDKELHEVIEKEYALRKKVANYPNYFSRFNNRPARITMLICFTLMLFQQLAGVGVIFLSAPRIFGLAGVPLPWAITTIILVCNQVVATLIGTLILDRVGRRILLLLSAMIMCICSTTIGTIFWLQENIYIQNSYVASIPIVCIFLFIYAYCLGFGAIPWIMAGDLCRMDIKAFVTSTAATISWFLVFVSVSSMHVLTVIVPIYLMFWIFACCTFTAFFFVFYIVPETKGLSMEDKQQLLHLPIGDKQIRNGPAWPVAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBY5</accession>
    <name>A0A835GBY5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBY5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF932">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="34"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9412501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="348" mass="37903" checksum="A29A052DF5CE340E" modified="2021-09-29" version="1">MSELAHTTEPTEPLLPPLALAAYVACVAGAAALANCSVIAALFKTSRSGLLTIILQLAVADLILGATLGPELWSYNARSWPFGQHSCVAYRGLTVFASTVSSYLVATIALHSLATIKVEEKAVAKRNKRNAQDEDEEIRSSRHSLVTSSDSSTPPRTMNLDYRLTDRRISVAPPSVFVWVLAISLSVPEYILASTVHQDHSVVLCTIVDNSQRLHMYSILAVLNLFLPLFIMSIAGALVIIKLKIKKILSQIECFESTAALKLSLWLIVIYIVLCTPRSFVTAYNIYSKSILGNETSLAPNNDMTVVNVATSSTFIISTLLRPLLSIALIPRVRKSFSFGSYTSTDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBY8</accession>
    <name>A0A835GBY8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000177">
        <property type="protein sequence ID" value="KAF9412828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000166">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="285"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="453" mass="52234" checksum="0B1606336CA26D70" modified="2021-09-29" version="1">MARIKPLCVMSQARQVYQPITILMIQKFVIAEKTSEQNKESDRQVHTSFEFLGDICTCLNLCLINKRSIAKTENEVAAQHEDQMIYSEDNNDLDYFDKHNKGSHLKGSSYSSWGRWSPCQDGHRIRRRHCLRRYICGDSLRIEIARVECSIINWQQVRQLKAEDVQRRFRGFSQWSSWSACSRKCTTVRRRHCLRRAICGRQVVRQSAYCYMEGSYCHLWIRSRMQRRKDPGYSTAEFMAATPAPAIHPQDSRAIPPTPPCGRVGRYRGSASARLRQRMRDMVRIIGGRPAPPGKWAWQVAVLNRYKEAFCGGTLVSLRWVVTAAHCVRKRLYVRLGEHDLLLRNRGEVEMKVTEAVIHPRYDPDTVVNDVAMLRLPEPARPDLGHGVACLPAPHQPLPPHTSCVILGWGKKRPTDVHGTRILHEAQVSTIQQSVCRRSYWQYAITDDMDNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCT7</accession>
    <name>A0A835GCT7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000125">
        <property type="protein sequence ID" value="KAF9414765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCT7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="22397" checksum="92A4FF317A24E73F" modified="2021-09-29" version="1" fragment="single">IRDAVAGNRNEDDVVLPPFDPEKNDNGAENWCNNIDTVAKDRGWSSITTVSKAGFSPTRLLIGCNGNIPPIQARLDEIQDNDYIQNNDSEADRDLARQNLRETAEKYKKRFDTTRRNNLVFKKGDIVYVNQNHRRHDKLSPKFKGPYEVIDILEHDRFSLKGLNTLRNIIVAKEKLKLWPGEWVEQNSSFEEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCX0</accession>
    <name>A0A835GCX0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000194">
        <property type="protein sequence ID" value="KAF9412290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006928">
        <property type="entry name" value="Herpes_teg_USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04843">
        <property type="entry name" value="Herpes_teg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="4">
        <location>
            <begin position="262"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C76" evidence="2">
        <location>
            <begin position="429"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="792"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1709" mass="193749" checksum="E2F0CAF42B48F390" modified="2021-09-29" version="1" fragment="single">MFWISSRFYSISLNFFVVPFNLYSLAKRRKLTQLDENTSDKNSFLSSQAARKAELRSQEDLFNRKRRLDSDAASKALRRSKENRVKRCFRNMKNASCTKISRSIETPDQRTFRHAKNAESTAASRLNETPEQSSLRRATNTQRTAESRLNETPEQSSLRRATNTQRTAESRLNETPEQHALRLTSDAVATALSRAKLRTDFQNSINKFADTICLICNKLCYSKQVQSVRLASLPENILPNELIAQHDVISACHRCVGILRKSRTPTQAYWNNMSLDEIPPEIASLSDVEVRLLSRIIPFVKMVKLGGRFGQHGFHGQAVLFGQDVEEIAEQLPLRISSAGLVIICEQLESVERLRQFSVNIQKLRAALDWLIANNPLYRNVTVNFNNENYDVHEICHVQNDDVTHQEKNTNETTCFQDIGNNRRILRGSFHQSHSKFQNFSRGKQCTSNAAVAITAAKIKETDTWSPNIIDSILISGDRLYSSSIQSRRVPNTAEADVEYLRVHELQVNFEALSHSCLLQIQDETSSICGHLTVSIDGFPNLKNGLIQFFTESDVDGGAIVTCNGVSVAIWKNDNLYYLFDSHSRGPKGRVAQDGTACLMSFTNITQLWSVLKSNLPKSQGNRPDDDQYSITKITPDVHRLHQNETELQNDIYTTANTQQLQSSELTNENIVITSSVLRVVDEPIPELSTVIENNNCDQLPVHQLRRKTDAPLQIAREKRAEELSWFKLFPYGRNGLQENRAHSITPLDYCQARIMGADNRFQRHDYLFYALSVMEFYRAKQNVGVVLRMRQGENRPENLVENIHLNMRNMRGSNAYWQSACSGLIAMVKNIGPPTWFLTLSCNDLNWNDILKAPASDDTVLLGPDETLRNNGRFCILTRKPEEQYVNNYNPQILKLWKGNMDIQPCGNVTAVSYYIAKYTSKHEPQDVGQAVKDAVSKVRSCHGDIGRQLFAVSMAILNHRRVSACECAYRLCHLKLRDSSRKVVFVNTCRPHERYRMLRYDSDDGQTYQNIFDRYIQRPTNLEHLSLAEFAVNYEHTSRFVNDEENGDTEAYEDLEEGTETTRNSIRLLNGSIMKRRRKPAILRTRYYTQTGDREGYFYSYLVAHVPFRNEDDLLADFETCEEAFMEQRNLLRPFHGDSVEQFQFIERELQQVIGQVLALAEPPLLNNFNGQQTENFDVGAIVEGYDPRMADADVDIEGEEVEESSHINITDAEFHHIVRSMNLEQKKIYDEVTKRIRDEVINEANTNVPLKLFVTGGAGSGKSFILKTLVHHIDAVTLPHQFIDILNNLRVGELSMEQYEILLERSRVPLAGDFADGNAVQIFPTIKLVNNYNDKMVELMADSVKIYTVNAHDESKEPATYGQKPNHVSIPQDPNCTGGLLSSIKIAIGARVMLRVNLKVSEGLVNGSMGVIKKIEWHGLRRDQLEEGELPKTIFIKFDDESIGKSSKDENGLIPIQPHSIIFQGGAGSGKSFILKTLVHHIRRCYAPTVDQLLNASFVEVTAPTGVAARLLQTNVRQQNDSQFIDILNNLRVGELSMEQYEILLERSRVPLAGDFADGNAVQIFPTIKLVNNYNDKMVELMADSVKIYTVNAHDESKEPATYGQKPNHVSIPQDPNCTGGLLSSIKIAIGARVMLRVNLKVSEGLVNGSMGVIKKIEWHGLRRDQLEEGELPKTIFIKFDDESIGKSSKDENGLIPIQPHSIIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDY8</accession>
    <name>A0A835GDY8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDY8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="74" mass="8256" checksum="043FCDD931D05378" modified="2021-09-29" version="1">MCGLCVFGRYACACVGAGTYRCANAAASTARGRERIPYRERDSLVSMPSARCWNTLWLDCNDKHFPGLCYKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE20</accession>
    <name>A0A835GE20_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000169">
        <property type="protein sequence ID" value="KAF9413102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE20"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032899433" evidence="2">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="151" mass="17386" checksum="40F646CD843C92F2" modified="2021-09-29" version="1">MKCSALVLVLMLCVIADAYKERRHFKHLNSRRANSKKQNTPPHCTQVTKDTDYQSRYRYDYPIAYIQPGQHEAYQQLYCVNPPTVNKAVTTVCDWAAPPQVQFTLGDEYMHVVRQDPTGRFLGNAVIRTYQLCNHNRTFVTDNSSVTVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE86</accession>
    <name>A0A835GE86_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000101">
        <property type="protein sequence ID" value="KAF9415836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1466" mass="153334" checksum="162941D1EE8E2F07" modified="2021-09-29" version="1">MNRGRGIAIHRELLAMIDHPSGPPVEAFVLVLFLNDDAEKLVGALDFNDFVLRIELNGCICSKKFGFDDVNDQISTLCKPADSTNKLSPSELLELQAKCQSLTFKDVERMWFKNIILSHHTETIMKERGMEKNYGTDSKNLKKIVDENMTKFKENKTNEKDHKLNEESSGMISNLYKTDGEGGGRIENKLEPIKNKQNLVPPSLLNKTKTIEPANDANEETKHMSIKNETDNENNNASGKLSISSLIAIKTIKPTNVVKEGNKTTQNENNKEKALGIEKMPPFLLNETKTIKPAYDGYEENKLLNAGSIFEDISHEGVTNTTPTEISSQLKELGYVNPDTLKEELSSIFYKTDNTIFIDVTVLEKTILLAEPICDCSSTPLFNDADSVNCTAATLFTNLGSEMMTDIDLLCEHIKKGDSYGHINRPERSRELENSAGENIQHQESHGSRIASATNNSLVTKSVHSTAPVPNQLRVTQLGSITAPGANNRSVTSQESQTPPEANKSAGTISTLGASHQSETHNNSITALGANNSIVTTQESQTPPEASKITGTISTLGVSHQSETQNNSITASGANNGSVTPQESQTPPEAKKSAGTISTLGIGHPNETQNKSMAASGASNGSVTMQESQTPPEANKSAGTISTLGASHQSEAQNNSITASGANNSIVTTQESQTPPEANKSAGTISTLGASHQSETHNNSTTASGANNGNVTPQESQTPPEANKSAGTISTLGASHQSETQNNSTTASGANNGSVTTQESQTPPKANKSTGTISIPGISHQSETQNNSTTASGANNGSVTPQESQTPPEANKSAGTISTPGANHQSETQNHSLTASGANNSQESQTPPEANKSAGIISTPGASHQSETHNNSITASGANNSIVTTQESQTPPEANKSAGTISTLGASHQSETHNNSTTASGANNGSVTPQESQTPPEANKSAGTISTLGASHQSETQNNSMTASGANNGSVTTQESQTPPEANKSTGTISIPGISHQSETQNNSMTASGANNGSVTPQESQTPPEANKSAGTISTPGANHQSETQNHSLTASGANNSQESQTPPEANKSAGTISTPGASHQSETQNHSLTASGANNRNVTSRESQTPPEANKSTGTISILGISHQSETQNNSMTASGANNGSVTLQESRSPLKANKSAGTISTPGASHQSETQNKSMAASGASNGSVTMQESQTPPEANKSTGTIRTPGIGHQNETQNNSMTASGASNGSVTMQESQTPPKANKSTGTISTLGIGHPNETQNKSMAASGASNGSVTMQESQTPPEANKSTGTIRTPGIGHQNETQNNSMTASGASNGSVTMQESQTPPEANKSTGTISAPGLGHQNETQNKSMAASVVNNGNAALPTSKTTQGLNNSNVTQNSTPRVWDTGHQNITTDKTTTGIATFSDTGTPFTQGPVKKEPEKYNIATILGLGILGFACGVVLAIAMTITYMRYRRRVYVTYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFB0</accession>
    <name>A0A835GFB0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFB0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="293" mass="32911" checksum="2E12969E030943C5" modified="2021-09-29" version="1">MDKPVTAKNFTIKSNISLILVRNQRESHSCQEHHQYANMDVKILPALKDNYMYLLVDRATNEAAVVDPVETKTVLQAVQDHQVKLTTVLTTHHHWDHAGGNEELAKQVPGIEIYGGDDRIGALTKKVEHNTIFNVGNLLVQCLFTPCHTMGHICYYVTTPEEGSDGVVFTGDTLFLAGCGRFFEGNAEQMYNAFSILGSLPDNTKVYCGHEYTLQNLKFAAYVEPSNEEVIKKTAWSEQRRVEGKPTVPSTIGEEKKYNPFMRVSELPVLKHAGAQNAIQAMRNIRLEKDSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFC8</accession>
    <name>A0A835GFC8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="7">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HF086_014105</name>
        <name evidence="8" type="ORF">HW555_006925</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000350">
        <property type="protein sequence ID" value="KAH9639241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFC8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000237">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9639241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="296" mass="33217" checksum="4989DE8D89F3E931" modified="2021-09-29" version="1">MSVKIEEQLKEKILNFAKKNPKGISHNDITAAIPEVSSAELVPVINELLQQEYFDLFKQNGVLVYKLKAQTSKQAVKGADNEEKVVYNLIEEAGNKGIWIRDIRVRSNLANTQLTKVLKNLESKKVIKAVKCVNASKKKVYMLYNLEPDRSISGGAWYQDQDFESEFVDILNVQCHRFLSQRAEKIKNNPRGPIVGRTQSYATANEVQKYITDLGISKVELDVEDVITILNTLVYDGKAESSVYPDGSKVYRAIDPLIPAPGLVQVPCGVCPLIYKCDSTGLVTPQACTYMKEWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFI0</accession>
    <name>A0A835GFI0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAZ-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deleted in azoospermia-associated protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline-rich transcript in brain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_007770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFI0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022730">
        <property type="entry name" value="DAZ_assoc-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11029">
        <property type="entry name" value="DAZAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9414292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="163" mass="16843" checksum="58C35A974F583FFE" modified="2021-09-29" version="1">MVTPPLGAYPQPQPPQGPFLPAPPHQAAPQYGVAGGSPYGVTFGGAGAGAGGVYAPPPYEQLQHHQAIPALSQQLPMYSPAAAMYAAAAGYPGYIGYPVQYYPYYPTAVQPSIQPLRPTIMIPNGFEAGGRFEGLAQTLLPPAPPGVPPSPAHLAAIQPHQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFV1</accession>
    <name>A0A835GFV1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000130">
        <property type="protein sequence ID" value="KAF9414563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFV1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF24">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="206"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="271" mass="31515" checksum="BA1F1C7C390FE576" modified="2021-09-29" version="1">MELESRIESLTQENKELMEALENERSLVKILREKVDKSNLLCDESKAEVNHLNSMVTEMQHDFLDMQRKFDKEKREKDEALLRNAHMSQTIEMSQCNVRYQETEIAELKSKIAELEGLIAQHKENQAACMLIKETEEARKQEIEQLKKKIDELIENETALKKTIQDLETEICDKNKKIKTLDNRISDMKKTLQRELQSSKSDLTSAEEQDISRRYLKHVVLRFLTARELEARQLTRALAALLRLSAHEEALLRAALPPRTGLAAWFPSLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGG5</accession>
    <name>A0A835GGG5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_007630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000132">
        <property type="protein sequence ID" value="KAF9414493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGG5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032999127" description="Coronin" evidence="9">
        <location>
            <begin position="21"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="72"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9414493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="678" mass="76328" checksum="BF3996A26B142303" modified="2021-09-29" version="1">MASVATVMNVIILELAPFSAMQLKDESIRETNCLEIINIVEKSPGKSTLVDVRACNKPAAKLTLDVFQVWFRGVRSSKFRHVYGVPFKRERCYDNIKITRNAHDSNFCAVNPKFVAIVTEVAGGGAFLVLPLDHTGRLDFNASRVTGHKGPVLDIKWNPFNDNIIASCSDDCTVKLWHIPDGGLSMHLTDWLVELHGHKRRVAYIEWHPTAENILLNRACFYSYLNLDLVPLLSPHGTIFVWDVGKGEAVKVIDCHTDVIYCMSFNRDGSLLATTSKDKKLRVIEPRRGIVLSEGLCHTGTKASKCTFLGSQGKVLTTGFSRYSDRQYAVWDQHDLDKPLVCETIDSSSGVVFPYYDYDTNMVYLAGKGDGNIRYYEVVDEAPYVHFLNQFLSGNPQRGLGFMPKRGVNTAACEVFRFYKLHTSRGLCEPISMIVPRKSDCFQEDLYPDTAAPQPALSAKDWLSGMNSPPLLISMKTGLCFRTLYSKEDLYPDTAAPQPALSAKDWLSGMNSPPLLISMKTGVTISTHKPRTSNKDAPAMQPQDANNRKKFAFLSRETTPDYRPLGTWQPNDHNNDSEHLDVQVNEKSQKTNANQNTKFHQLQRMFGKQTGDAEPVPLYKQINQGDVFSTEHELRLAFNRQGEELRIVKRQLQNSQQRVRELEQLVAALQARLQRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGV2</accession>
    <name>A0A835GGV2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abasic site processing protein HMCES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Peptidase HMCES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">SRAP domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_006289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGV2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9416335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="36259" checksum="672A8BA67FBB550A" modified="2021-09-29" version="1">MCGRTGLSLQKEKVQCACSYKPKNYSHYVKPEWLPEYNAGKDYVPSYNIAPTDVTPVLVSSSRFSNVVNCDRVLKPMMWGIIPPWHKGDFKTHNLSTNNCRLENIKSSKLYSPILNSGGRCIIVTEGFYEWQTTNKLSKVKQPYYIYAPQQDGVKIDETDTWNNNFDETTGWRGIKLLCMAGLYHIWQNEETVIYSYSVITMESNETLNWLHHRMPAILSSEEQIEAWLDIDNVKPDMALGYLKPIKLLSWHPVSTAVNNSRNKTTSCNKKILEEDKSKKKTQKTLQSWFVKAEKRKSTDNSDFEPTPKSKKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGZ2</accession>
    <name>A0A835GGZ2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGZ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="187" mass="21054" checksum="463A785AEAECEFBC" modified="2021-09-29" version="1">MADFVSTSVKLLSFANNPPKRTILIVIVFELTEPFSPVAPSDVRKNITAKLAINQQKYCYALAVTSSFQLLKDPPSCLVHCDVMIHFDSLTKEFVKACMAVWFVVLFFECAFIELSETKRAYEVFWVEFSEHGCDATAGDRFVAAGTERATFAVVVGLTVRLAFVLEERSSMERLATFLKTKEHSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGZ6</accession>
    <name>A0A835GGZ6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-like GTP-binding protein RhoL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_001324</name>
        <name evidence="10" type="ORF">HW555_007090</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000115">
        <property type="protein sequence ID" value="KAF9415214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9634122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGZ6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9415214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9634122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20884" checksum="5F4B55231860ED6F" modified="2021-09-29" version="1">MGTTKRLKITVVGDGMVGKTCLLYVFTKDEFPEEYVPTVFDNYVGHITVDGEEVEIALWDTAGQEDYERLRPLSYTHTNCFLVCYSVGTRSSFENVIHKWYPELKHFNEKVPIVLVATKTDLRASGNAVVTTQEGKKLKKKIRAVQLVECSALERVNIHEVFEEAVRAALRKTPVHKRTCQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH03</accession>
    <name>A0A835GH03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="169" mass="19340" checksum="336923010D3C7600" modified="2021-09-29" version="1">MIKIRTASKHGWLQELESNSQAVTQCSRKYLMLFPSTAAMYHGRGSTKLMLRCLQTIILVTIVAEYVHAYEIDKEHQGPQPCGGRLKGPVGTITTPNFPNPFPVPIKCKWIIEHDIVNGTISIYFTQQYTTSGLTFTEYMYYDESYKLGERRALTLTDENITRIKWLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH33</accession>
    <name>A0A835GH33_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH33"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="301" mass="34443" checksum="9F46626CCF20AA2C" modified="2021-09-29" version="1">MNRVPIFEEYRLIERSELEINGAWKGAHLLLFFLAFVFGSFCTFCFHMLMYLFDEKCVLFPKLLSLTTLKHNVIYEFMPATKDFADQHLFPTDVRSLVSGIFGLVWTTMFLMCSTGSRTLSGLQRPWRVLPPVFVFSLAMGSLCIYSSTITHYGLQELCVKLGEITGSPTCSYTINVATLTYERRIRGVYQATRLTILSAWLHTACWLLSAILALVRVLLAVDFQLVRVSVHLHGDIDALLEKHEVQIRTVSPDTWFNEKEECPSNINLSNPTKFPLKSILRALKREAEAHYKQKKANSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHP9</accession>
    <name>A0A835GHP9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Talin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000088">
        <property type="protein sequence ID" value="KAF9416555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10569">
        <property type="entry name" value="FERM_C_Talin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17089">
        <property type="entry name" value="FERM_F0_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17090">
        <property type="entry name" value="FERM_F1_TLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000001">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000007">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000028">
        <property type="entry name" value="Talin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057346">
        <property type="entry name" value="Talin1/2_VBS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015224">
        <property type="entry name" value="Talin_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036476">
        <property type="entry name" value="Talin_cent_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054082">
        <property type="entry name" value="Talin_IBS2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049108">
        <property type="entry name" value="Talin_R4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015009">
        <property type="entry name" value="Vinculin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21896">
        <property type="entry name" value="Talin_IBS2B"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09141">
        <property type="entry name" value="Talin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21692">
        <property type="entry name" value="Talin_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25177">
        <property type="entry name" value="Talin_VBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08913">
        <property type="entry name" value="VBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109880">
        <property type="entry name" value="A middle domain of Talin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="139"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="7">
        <location>
            <begin position="3164"/>
            <end position="3400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1733"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1808"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1894"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1978"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2058"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2629"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3243"/>
            <end position="3266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3403"/>
            <end position="3448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3467"/>
            <end position="3491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3833"/>
            <end position="3854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1740"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1826"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1912"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1981"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1992"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2061"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2072"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2637"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3249"/>
            <end position="3258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3428"/>
            <end position="3448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3834"/>
            <end position="3854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3854" mass="422389" checksum="35062C23380BBECE" modified="2021-09-29" version="1">MKNTVESRPRVRSFSQERPRRRRPSATSLDLQSETVYHTATIHRAHSLSKMAALSLKISIEGGKVVKTIQFDPSTTVYDACRIIREKILEASSGDPKEYGLFLASEEDNKKGIWLEASRSLDYYMLRNGDLLEYNKKTRNLRVRMLDGTVKTLLVDDSQVVANLMVVICTKIGITNYDEYGLVREEQKEEVDPCEKPNFGTLTLKRKHQEKERDAKMEQLRKKLRTDDEVNWVEPSKTLREQGIDVTETLLLRRKLFFSDRNVDSRDPVQLNLLYVQARDAILDGTHPVTMDKACEFAGIQCQIQFGDHREDKHTPGFLDLKEFLPASYVKVKGIEKKIFKEHKKHIGLSELDAKVLYTKSARDLKTYGVAFFLVKEKMKGKNKLVPRLLGVTKDSVLRLDEKTKEILQTWPLTTVRRWCASPNTFTLDFGDYSDQYYSVQTTEAEQILQVIAGYIDIIVRKQRAKDHLGIEGDEGSAMLEDSVSPSKANIIQHDTFKSGKVNTESVAKPAVHRPGAEGAKPFAVNHMTGAQQTTVSGQIITGHTPPAASQVQQTRVTSILSEPQRALLSTISSGVEIIKHTEEGLTRATLPALGQDAASVKWKQVTMDTNKQVVTSQIAAMNAATAQVVTLTSGTEEVDHTAVGAAITTITTNLPEMTKGVQMIAALMDDGDHGDKLLDATRKLCTAFTDLLKAAEPETKEPRQNLLNAASRVGEASTTVLYTIGEETEEDKETQDILLSLAKAVANTTAALVLKAKNVAAQCREDQPLQNSIIAAATHCALATSQLVACAKVVAPTLQNPQCRSQLSHAARQVASAVQRLLDACSGAPPPAAPAVESLTAAAHNVTQELERLLAHCELERRVTGTVSERSVESVMCASERVVAAAEAGDMVRHARLLGQATAHLITTIKTEAEKQPSEGQRKLLAAAKLLADATARMVEAARQCASEPQDREKQEALRKAAEELRYITVDYAQGQDIVGSQESARQAASSATQLITSAHNATQYNTNKYTQETLIEECKSLNEQIPRVVDAVKVSSLRPADPAAQLDLISASEAFLQPSGHVIAASRGALPTVGDGPTAKHLADTTHSFTTSAADLRSAVGRARISCKGLELDAAAEIIKSLQAELDELEEAARALELRPLPSQTALRDFSAAIRATAALQHDAQRTQQVITSGRQVLYSSQTLVEHVKRCLTTSETVDTTSIMSIAKDISQGLEATLEAVPSHTELDVAMENINETLNILNMGEFPPSDKSYGELQSELNAAAVGLSSAASDVAQSVDSPPALAASGAAFGGAFNRLLGVSMEMAGHTEDRDTQTLMVSSMKSVTVNSSKLLGTAKSVSQDLTRPNAKNQLAAAARAVTESINRLVDVCTEAAPGQKECSAAIRSIRSTAALLAAADQPLSELGYFACLDAVVDHSKSLSEGMSLMASSVKRSEAEQFSRAVGTVATAVQGLVECTAQAAYLVAVSDETSVAGRPGLVDQAQFARAAVAIEQACRALCDSSSNQQQAAKDVANSTAALVKDIKALDTDYSQENRARCAASTGPLQDAVRSLCQFADSPEFASIPAKISPQARNNQEAILECGRNIISGSCSMLESARLLGVSPGERSHWQQLAQHSKTVSDSIKGLVANIKEKAPGQRECLAALETLNRQLRELDQAAMQAVGQELLPRKNNTLQGYTEQMENSATEMLERLEPLRVAANGEAENLGIVRGAAGDGRGGGELEPVAVGDAGRAAGARADRARDARAAHARRARRRGEPTGTASSSCSSSSAYRSETQAALLEHARTVLETLALLMHDARAAAGNPRVLPHHHVGDAGRAAGARADRARDARAAHARRARRRGEPTGTASSSCSSSSAYRSETQAALLEHARTVLETLALLMHDARAAAGNPRVLPHHHVGDAGRAAGARADRARDARAAHARRARRRGEPTGTASSSCSSSSAYRSETQAALLEHARTVLETLALLMHDARAAAGNPRVGDAGRAAGARADRARDARAAHARRARRRGEPTGTASSSCSSSSAYRSETQAALLEHARTVLETLALLMHDARAAAGNPRVGDAGRAAGARADRARDARAAHARRARRRGEPTGTASSSCSSSSAYRSETQAALLEHARTVLETLALLMHDARAAAGNPRAVSAHSKVESQVSQCRAALGELQAQVRELSAARGAVGPLLDSMQRAIARLTDHRMSLIGSYDESDSFVDYQTRMVGAAKEIARLATDMTAKSATDASRLVQLGNEMCQKYEQLAQDSVGASATTPNSDIANRIRVAVVELGEGVSELIKAGGHCRLSAIPQNQRAVADSAKIVNEKVIAVLSALQAGSRGTQACIDAAATIAAIIGDLDTTILFASAGTLHSEKESDTFSDHRENILKTAKTLVEDTKTLVGGAAGTQEQLASAAQSARLSDATRRWSLPLKATTIPRQNRRSAILRNDYNSADSETDIFQSDQEDELVKLLDYSSQDDDVSPTIFHDNCEEIITYIENKMTIPPVRSLKNDDLNERYNLAAKNSLLDMDWRVLKYGENILLGEVKKLADMVHDLGDKEENKRKRDKIQRLKANNDLDTEMKRLSAVIENLDTEIQINVKTEVNIETVTNNKPKLDNGKLTSPVFKVKKVRPVSLDVQTPSPEATEAAKELLSPEEKQKDESMEIVVKPDVKTRDVTDISTMTKKVRMEFWKMFKDDTEWWKALAKRNLEKMEETRRELERFSGHELVLGEFQTQLDRFENEKHTLQNFIDEVDKSKAVNQDLEYNKKYEDMVLKLIDFAKKDFIYKGFDPLIEQLKALANVKIDRKKKVDIQEILNIYSQIDTSKYTYEELCLLERYYKEIIRKYKKDFRDKENIIPENRQVYTTNSLHRNINRTIIHNTDTIKSTRSNPEKHRNSIEIMDLTRTYPMQYYANNWWTIYEDVLRSREQQFGSIDNWWQVYERILNKTETSEDLERFQSLMRSQSKSRPSSRMEEQLRMLDEIRNDRFKETEAVTRLDDESVMVTNVTSLLKTVKAVEDEHTRGTRALESTIEAISQEIEVLMSSTPPKSTATPEELIRCTRQMTVATARAVSAGNANKQDQLTAAANLGRKTVVDLLVVCKGAAHAAETEELRTRTLEAGRAAAQAYRALLQGVLAACGGDAAARHHLPDLSRHVAHATADIIATAELLKGSDWVDPDDPTVIAENELLGAAASIDAAAKKLESLRPRKSVKVQEADESLNFDEMILEAAKSIITATSALVRAASAAQRELIDQAPRRGSSPAPGRSRPPPRSYWSHARYVHSLVEAANALVQGAGSEERLISSARQVASSTAQLLVACKVKADPSSESTRRLQAAGAEVIRSTDNLVRAARDAIHTEDERSLVLNRRMVGGIAQEIDARSEVLRIEKELEEARGRLTAIRQAKYKLRAGETSGEDTDTDLQLGYTSDTAPHRFKTPNSSFANTTYSPNSTYSPHTTQTLNTTNISSHITQLNHSIHGTPAKSPVSPGYYSTPKSPTVPARPDQYTQSFNQEKQYTVQSPSFSSFRPAEEPKQNYEGFTTRLSSKDRTMNEHYETRLYDTPRPLHETTTERQETLYDYKEHKYGYEPPKTPLSPKFNARELKFDDKEPIYSTLKKPFDGVGQTFSEHQKSSEAIPGGVKHSEFKVHSESYQSYPKTEYSKTEFREEVKSPFASTPKFDRSTELVKAATPDYDRIASPYKESTSYGGPNYMEETTTEVKEIPNGTQKITTTKIYSSSPVNLTTTNTKYEPIRLDGIDELSKSFDNDSKYSTLDSRFNTLESKMSSDTSRSFMRPSEFQSSDYQSTTNVTKVKKPSELVKEIDSLDKKFSKQTITSETIERKSVMTSSHKSESSSTITKKFGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI59</accession>
    <name>A0A835GI59_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_006499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI59"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12738">
        <property type="entry name" value="RRM1_Fusilli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12743">
        <property type="entry name" value="RRM3_Fusilli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000041">
        <property type="entry name" value="Epithelial splicing regulatory protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000070">
        <property type="entry name" value="Epithelial splicing regulatory protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="119"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9416087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="538" mass="58557" checksum="2F17A0EE5F153E36" modified="2021-09-29" version="1">MSFKARTRSKDDEIDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPQGRRNGEALVRFVSQEHRDMALKRHKHHIGSRYIEVYRASGEDFLSVAGGATCEAAAFLSRGAQVIVRMRGLPYDATPQQVLDFFSAGENPVMVLDGAEGVLFVRRADGRATGDAFVLFAKEDDAPKALSRHRKSIGARYIELFRSTTAEVQQVLNRSLETRTSQSSTPSTAPTPAEGLLPVALVPQHVITSGTAKDCVRLRGLPYEAQVEHILTFLDEFAKNIVVQGVHMVYNAQGHPSGEAFIQMDSEASAFLCAQQKHHRYMTFGKKQRYIEVFQCSGDDMNLVLTGGVTPATSPKVLSPGTLVSPPPPAPAPRLLAQHIAHQSLLARQHENLLLASLRPPIVPILPTYAAVRSQAPSAQAYQLPQMSQMLQQQTMLPTKRSYERAFQPTEAAPAKRPYAMPPQMTPALSLPVFSYGTSAPIFSYANTSPMLSTYNTLPTALPTALPAGYGSALSAALPGTMTSPFPTLSMFPTYPYYPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIA9</accession>
    <name>A0A835GIA9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIA9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="27559" checksum="54103EE9F3FDE442" modified="2021-09-29" version="1">MHRSQSSFLRACSVQGLEDYDTPRAPLLRQVSLDEERRDECQGHWRGPELQGEEEERGVRLFRALLLQHLRLEHLRPPPCFVAPAKPDQRGWWMYWRDWRSLERAARRFRETKARARLAAEAEHISLLCLDEVEFEDIMQELCQACVHTEQRALVVLAFLCEVCARAVRVGGWCRAVDWAAKHVAQCATPWAIKHGGWSTVVERAGGSRRDETTLLAGAALAALLAFLLFCRARLRTALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIE5</accession>
    <name>A0A835GIE5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_006777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in apoptosis. May act as a tumor suppressor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000106">
        <property type="protein sequence ID" value="KAF9415632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIE5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04152">
        <property type="entry name" value="Arl4_Arl7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000898">
        <property type="entry name" value="ADP-ribosylation factor-like protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9415632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="236" mass="26055" checksum="D24EAB8E37681902" modified="2021-09-29" version="1">MEHGVTQTSRDGALGRQCKITATRLRSMGANMGKNSSLLDALPTAQGTLHVVMLGLDSAGKTTALYRLKFDQYLNTVPTIGFNCEKVKGTLGKSKGVNFLVWDVGGQEKLRPLWKSYTRCTDGIIFVLDSVDLERMEEAKMELIRTAKSPDNTGVPILVLANKQDLPGAKEPRELEKLLGLHELVSSPHGSRDAHAWHVQPACAITGEGLHEGLEALYEMILKRRKLAKLQKKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIE9</accession>
    <name>A0A835GIE9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_005453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000071">
        <property type="protein sequence ID" value="KAF9417450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIE9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="3"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9417450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="473" mass="53225" checksum="A31E48BE2544CEEB" modified="2021-09-29" version="1">MTISSGGWTCYFIMGMSFGASTVFIPQIRKEANSDDAISESTASWIPAIMVYSGLPWTFILPIFMKYIGRKYTFMFVSISNLISFIVFYFSVTVNQIIISQVINGINTGSHFTVSVMIITEYTSPKHRGFFLTVKSATLFWGIFMSNAIGTFFHWRNIGLAGIICSAYGLLIAIVLPESPFWLATKQRYERAADTHRWMMGFGKQAETDLEKLINYQKNLNLEAQKKKFELKGYIIGYLRIVSKRQFYKPLVLCLIVHSLYIFSGKVVFSVYAIDIISKITAGHHISPYTAMLILDGVTVLCMYIGCLVAKVLPRKKLLIGSSLVGIGFLLSISLYAYLIKLSLVVENNYFAIFLLIGYSMGLCFGPVILTQTISGELVSIEARGLSSCCMDLSSKVLLGTLVKMSPFLFKSWGTHGAFLFFGLATSFFLFLIYVFLPETKDMTLQEIAEWMKGTKRAPVVQEEMNFLPQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIR6</accession>
    <name>A0A835GIR6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000085">
        <property type="protein sequence ID" value="KAF9416696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIR6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9416696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="146" mass="16188" checksum="71D3DDA528804275" modified="2021-09-29" version="1">MSDWDTVTILRKKPPKASALKTEQAVNAARRQGLPVETQQKYGAGTNKQHVTTKNTAKLDRETEELRHEKVPLDLGKLIMQGRQSKGMSQKDLATKICEKPQIVNDYEAGRGIPNNIVLGKIERAIGIKLRGKERGQPLQPPGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ11</accession>
    <name>A0A835GJ11_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ11"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20454" checksum="5676BABAAF11C737" modified="2021-09-29" version="1">MQTFSPEAALPDGDVYSALDESLLMWKGWLEICQLIPNKAAITRGGGTYEIFEFHTGYLWRFEIHAHKKAQPQQFLPVPVQFCLARRLKSLGFDCVGTLRTDRKFVPQALNSLTKRNMRQGQITGLTSGDVDVMVWRDTNRVAMIPTYHGNGQQTTRESTKPILILDYNIMMCRVDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ73</accession>
    <name>A0A835GJ73_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_005955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000083">
        <property type="protein sequence ID" value="KAF9416825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ73"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11798" checksum="F2F047AB12A04F93" modified="2021-09-29" version="1">MLMCNVTEQESVAIISNYEHHYCERNAANRKMIRRPLTEITLKLDDLQEYESFRREQGNNSSSTTEMQEDTPKPLDVVKTIEEIHNRIGYAPKKKLSGPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJV7</accession>
    <name>A0A835GJV7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJV7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="374" mass="43003" checksum="EF36ED0A2EDA56ED" modified="2021-09-29" version="1">MGKHRRKREEEMKELNDRLRELENRLNNKKKSRHRTSDAYARYSSRSDSSGSRSRRSRSKRSRSRRSSPTPSYHSRSRSRRREYSDHSCEPRAERSSTSRDNDTPCHHTTPSLDKEADQEGVTASLPDALPPGIEELLGDEGVQPIKTPVELHNSLATRWSTIIVHGLNEETRKNIINKQETPKNCSLLNPPKLNEEVAAALSDSGVKRDSRIREQQITLGAAITSLGKVLNTLIANQDTTDQILTLSNAARLLCHIYHENCITRRSLILPGLNKEMKELMEQTPISEYLFGDKLQDKFNAIKAVRKSGQELKNMPARPPTRPKRNLNYRGPHRQQFPRPGGQKILLKRNKPPATRQRHSPQRRQQRRRGQERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK22</accession>
    <name>A0A835GK22_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_010011</name>
        <name evidence="11" type="ORF">HW555_004011</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000322">
        <property type="protein sequence ID" value="KAH9639604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK22"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00751">
        <property type="entry name" value="menA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9639604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37160" checksum="FA9FB94E3AC36932" modified="2021-09-29" version="1">MDINKKSEDMDIPTVEGNLLQQPKEETTPTRNPLMKVRTYVLALRPWSLSASLLPTLLGAALAYRLPGDSGFSWCTLLLTLCTIIPVHGAGNVVNTYFDFVKGIDNRKSDDRTLVDHILSIDEVVSLGAILYLAGCASFVPLVILSPARMEHLALVYFGGLSSSFLYTGGIGLKYIALGDILVLVIFGPVSVVFAFLAQTGRVDWPIIYYAIPLALNTEAILHSNNTRDLETDSKAEIVTLAILIGRTASYLLYAFLLFTPYIMFVVASVRCSLWFLIPLLTLPRAFEIERRFRSPETMRYVPRQTARLNFYFGMLYMISCLFAHRLPFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK69</accession>
    <name>A0A835GK69_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK69"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032895728" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="200"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="546" mass="61269" checksum="6FF6CB06AF524724" modified="2021-09-29" version="1">MIQECASIVLLLVQISTLSINTFEIPIYNIRGKPHSLLANLEKTQKKFCLFANCNALNTLYDVIDSLNNKRNIGERLLNNFNGRPYNILRSLNNDVKPPLAEVQPAFRRLYAASPNPVYNNLRSLPDWFTPMAAALPTLVNNPSNVPHNQLPLKPHTMTAVTDVSQQVIAQSKMSPIEKFTQGLDHFERQFYKITVAKLTSISPAERQENGMSFVQSAFFLLLTLMVLSKEVDTATRAQIDQCIGFKISDLESIGLVRHLISTLPSSSDKLTLRHGSRLMLWPGRPEPRFQGGAAAALKLRVERFNGTEATDTIATILNKKVELDSGGAMHDTFDEGDVSSGVAAVFITTLYMRGRWRTSPTVLNGTLPFHDADAAPKRTVRMIRINDIMKYADLKDWDAQALEISYATPGLTLLMLVPRSTSLKKLAQHVSNTSVGHIMSKMKTMRVAATIPIYTLRMTLLLPNKLQAMGIPRLVDVSNVTDTRSLRLSHAVQRVMFWAEAGRHAYKDDGIEWDQKPQLEVIANRPYIFFVRWRNVTLLNGNFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKI7</accession>
    <name>A0A835GKI7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKI7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033108692" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="476" mass="53964" checksum="7DB3254FCD645D93" modified="2021-09-29" version="1">MKGSIAVLMLCLSSGFAYKILCILPVPSKSHDHLSLGIVKPLLKAGHQVTWATPYEKKNIHENLTVIELKEIREFVEAMDIMGKSDVGFQYMKEFSRNISISTTQHPGLQKVLVEQQFDAVVSVWFMNEFEAGYAAIQQVPWILVSSISYHPFLEKQVDQVRSISTVPLAFNDNGDRPMSTFRRFINGLIYMLMNVDEWFDKSTITSTYESIFSPLAAKRGVPLPPFEDAYHNDLQELLDGSPQGVIYFSMGSILRSSSLKPHTRDALLKLFASLPFTVLWKFEEPIKDLPPNVHVRPWMPQLSILVHKNVRLFITHGGLLSTLEAVYAGVPLLAIPVFGDQPSNAERAELAGYAVKVAFRDDMVPDVAAALQKMLSTDTYYNRVKQISKTFRMRPVPPSDLVKFYIELAIETKGAYHIRSPALEYKWYERWMLDFVLVVVAVLVTLVTLIKLAVTAILRRILGKKQKTQSLKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKK8</accession>
    <name>A0A835GKK8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_010297</name>
        <name evidence="2" type="ORF">HW555_005712</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000906">
        <property type="protein sequence ID" value="KAH9628563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKK8"/>
    <dbReference type="OrthoDB" id="7354947at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9628563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="182" mass="21031" checksum="31835441DE5FEA7D" modified="2021-09-29" version="1">MGCLDLPKMTHCCYCTRKFRLACILIACWSMISTSHSIRILFCPACTKVYTREGGMFYIAMIVVMWLLFLINVVLLSCSFFFLLSLFLMVYPISADLFMLFGFISSIFMIIHALINIAQIIDSDCNNPSDSIAHFLYSILWVYFIFIVNTYRDEMRCYPGELVDEDDPKIDKDKVDNSTYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKP6</accession>
    <name>A0A835GKP6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="13">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="13">A-SCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Succinyl-CoA synthetase beta-A chain</fullName>
            <shortName evidence="13">SCS-betaA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HF086_001263</name>
        <name evidence="17" type="ORF">HW555_004135</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="11">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000624">
        <property type="protein sequence ID" value="KAH9634061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKP6"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9419208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9634061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="452" mass="49465" checksum="3B7E4BCB1B8D1C40" modified="2021-09-29" version="1">MATLLPRPLGLAQTLLFKNGSKLLVASLNHPSQQQVRNLNVHEYISYTLLRDHGIPVPKFHVATTPEEVVKFAKELNTKDIVLKAQVLAGGRGKGHFKSGLQGGVKMVDSPETAGKLASQMLNQYLVTKQTGAAGRICNKVMVTERKFPRREFYIAIMMERSFNGPVIIASSQGGVNIEEVAATNPEAITYEPIDIKTGIQDDQITRVLKKIGLETAEAHDMVKKMYDLFQKKDALLIEVNPYAEDAITGQFFCLDAKFRFDDNADFRQKELFSLRDLTQEDPKEVKAAKHNLNYIALDGTIGCMVNGAGLAMATMDIIKLHGGDPANFLDVGGGATAQAVAEAFKIILLDPSVTAILVNIFGGIMRCDVLAEGIVTAAKNLNIQLPIIVRLQGTKVNEARKLIAESGLRLVPRDDLDEAAQLVVQLAEIVSLAKKAGVEVKFDIPKYMLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLI9</accession>
    <name>A0A835GLI9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLI9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="507" mass="57803" checksum="9CA64C6D5D6DA36A" modified="2021-09-29" version="1" fragment="single">VKTYGQRLRYYCGHTACDDCVVDVIDCSICLTPPPISTQKARLDDVLTQRAQECITFTRKRLSEQLRIEKELFPECIQAPLKYENKRKTSFNLSKNKENREYSVLPGEAISHLDKNNTMENSFKYVQQWLNNNDTDFVRKPFRDLNVNTQLDPNVKHSSNLKTLSKTNRKRAHYKTTVKTQSFVSPKKKSVIHNDFMNQKKVKKESPHTSLLKYETKTEHDNDESGIFLDDPIVIDDSQETAIDKDRNAWLAVLKANEHEQNESTSVINLVCSDTQTSIPINKDIVIGSDKKQTTTNQNVPFFKKSYIIETCKLCDVDKNIIAQTEDVKITIDNADFTTTIQIINSTGNGSKLKAKKSVSVQTDLLENINCDDSAVANLNETNYKFEGAPQNSDTLSEDLFGDDSKHNENDRPGNDYRRVVIAESDSDMELETSGPLPVKVDVHRSCDETEYGILSEIENIQDHSARSRRGPRGLTPTSTDSSEKENFNPNRMKTQTYKKKKYSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLP7</accession>
    <name>A0A835GLP7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_004474</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLP7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="276"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9418807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="423" mass="46110" checksum="584232C529BED9AA" modified="2021-09-29" version="1">MAVSVSTKLLSLCKNSANIRALSTTSAKTAKISFNWEDPLNLDGQLHDDEKAIRDSFRAYCNEKLLPRIIEANRNEVFDRTIYKELGELGALGCTIKGYGCAGVSSVTYGLMTRELDGIDSAYRSAMSVQSSLAMGAIYMYGSEEQKQKYLPRMATGELVGCFGLTEPNFGSDAGGLVTRAKYDAKSKTYVLSGSKTWITNSPIADILVVWAKNEEGKVRGFIVERSQVKKGLDTPKINGKFSLRASATGMILLDEVAVPEDNLLPNVVGLKGPFGCLNNARYGIAWGVLGAAETCLRIARQYTLDRKQFGRPLAANQIIQKKMADMMTEIALGFQGCLRVGRLKDEGKAVPEMISLLKRNNCGKALEIARTARDMLGGNGVSDEYHIIRHVMNLEAVNTYEGTHDIHALILGRGITGIPAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMG4</accession>
    <name>A0A835GMG4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAMTOR4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMG4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034601">
        <property type="entry name" value="LAMTOR4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33967">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33967:SF1">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="10782" checksum="7319B759E60A9253" modified="2021-09-29" version="1">MEKIPDQIGYLVLTEDGAVLESGGELENDERVATIITDLISLSNKVDPVAFGPNEQFKKISITYDDHWFVICLSNKKIYVVKRSIQPSISEGNAINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMU8</accession>
    <name>A0A835GMU8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="20">ETF-QO</shortName>
            <ecNumber evidence="20">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_002127</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 20">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="20">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="20"/>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMU8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000088">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 20" id="KW-0274">FAD</keyword>
    <keyword evidence="7 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 20" id="KW-0813">Transport</keyword>
    <keyword evidence="17 20" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9422106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="592" mass="64431" checksum="EC8EFC1190B259C2" modified="2021-09-29" version="1">MAAALVSSSRQVGRLTNAAKRLYSDAYPKITTHYTIHPRDKDPRWKDINMERVAEETDILIIGGGPAGMAAAIRARQIAEEKGAEVRVTLLEKAAEVGGHILSGACVDPIALNELIPDWQEKGAPMNTPVTSDKFGLLTKSGRIPIPVFPGLPNYNHGNYVVRLGHLIWPGCAGADLIYRDDGSLKGVATGDVGIAKDGSPKDMFERGMEFHSKITIFTEGCHGHLTKMISNKYNLRANSEPQSYGIGLKELWEVKPENHKPGLVEHTIGWPLDKNTYGGSFIYHLKVAEGEPPLVAAGFVVGLDYSNPYLSPFREFQKFKTHPYIRPMFEGGSRIAYGARALVEGGWQCLPVPAFPGGLLAGDSAGFLNVPRIKGTHNAMKSGMLAAEAAMDLIISGEATHEKGVVPTQYEEKLKESYVYKELKQVRNCRPSFHTSLGLYGGVAYSAFSTLMRGKEPWTLSHGGADHARLKPAKECQPIEYPKPDGVITFDLLSSVALTGTNHEADQPAHLTLKDDTVPVKQNLGIYDGPEARFCPAGVYEFVPMESGDGQRLQINAQNCIHCKTCDIKDPSQNINWVVPEGGGGPAYNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNX8</accession>
    <name>A0A835GNX8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNX8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9209" checksum="688716C45E63096C" modified="2021-09-29" version="1">MTVDYRLCQETPKEKHCLIEYSVRYRWPHQVRYVFNWHTKSCFVIRWSAHCPAVPSPFISNNFPTENECLDECGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA0</accession>
    <name>A0A835GPA0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPA0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004941">
        <property type="entry name" value="FP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03258">
        <property type="entry name" value="Baculo_FP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein N-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FP protein C-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="271" mass="31195" checksum="802A3FE57A48A923" modified="2021-09-29" version="1">MKIKTFSNTGLCDECQISQTDMSSPIAVDVLNTTPEKLLAEVNMKLSIVFTMQKTLEAMSEDISFYAEKYQELIEEKEKSDKKIKALEHKNVHLETSIKALEERVSYLEVREKGKNIEIYGLEEKQNENIENTVKVIASKLGIADGKICEAMRVGEEVKSDKKQRDSKPRPIIITMATRTARDKWLATRKTHKLTNSDILENGNKQRIYVNEDLTKHTRNLLWTAKSELKPTFKYIWVKNGKVLIKKDDPNDAKIKTIRTLSDINMYVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPF2</accession>
    <name>A0A835GPF2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPF2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9422194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="407" mass="46973" checksum="6B454945099D50E0" modified="2021-09-29" version="1">MEDDPQFSELVWQAEVAIDNGIFPERIYQGSSGSYFVKNPGGKIVGVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRSCLIPNQGYLSEAGASLVDSKIGLKIVPKTRVVKLVSETFNYLRIDRERSRLKRAITEQFPNLRFNRMGLPPKAGSFQLFVEGYKDADYWLRRFEQDPPPPHVMRKFQLQFERLVVLDYIIRNTDRGNDNWLIKYDSPSQQPPHADIDLRDPSEWRGAEVRIAAIDNGLAFPFKHPDSWRAYPYHWAWLPQAKQPFSHETKELVLPLLSDMNFVQELCDELHVLFKQDKGFDKGLFERQMSVMRGQVLNLTQALKDNKSPVQLVQMPAIQERVDVVPFLRLVPATLPAQVAFLLLVVRLHAARCISKNGDKFHLKLKISDINTTVCICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPK3</accession>
    <name>A0A835GPK3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_002871</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPK3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylguanine DNA methyltransferase ribonuclease-like" evidence="13">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9421159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="183" mass="20173" checksum="E7E00AB72DA75278" modified="2021-09-29" version="1">MTLTKVLAKYSKNSGHAVNVQSYDSPVGNAIAAADDDFLYIVTFENSKNFEKCFETLAKELSCSFVESENKILKRFEKELSDYFEGKLKKFTVPTKTIGSEFQKSVWDKLLELPYGSTQTYGDLAKDLGRPPSHSRAVGAACGANPLLIVVPCHRLVASGSKGGYNSGVDRKDKLIELEKTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPS4</accession>
    <name>A0A835GPS4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPS4"/>
    <dbReference type="OrthoDB" id="6874264at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16876" checksum="E5AF461D227EE8C4" modified="2021-09-29" version="1">MSIPALRQPKTIEEKIPTYNEPQNFLIVTLNDGKKLVVSSDAYHGILATGQLNRCVFCETEMVRDVICKERHKASENHRKILEGYPHIDEFKENLLRKLNAANYYCTICNDVVMMHYARRHIQESSHHQELCKAKARALSYKPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ15</accession>
    <name>A0A835GQ15_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_002763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ15"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="10">
        <location>
            <begin position="369"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9421291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="713" mass="79924" checksum="0A5CB65D14289340" modified="2021-09-29" version="1">MSDNDELAQLEELLCADLNELDNNDTKQVSVREVDIFDPSTSNLGDKEDEKVDESKPGKNSAIHNGDTDSSDDEEQRNYTERKYSNYGTEVKKILDQQQDEQRDKRLDFETRLRQTNMDIKVAQSTFKSKKPIEQVSKNTFCAPEIKKPKESADIYTDPVFGIRITKPLISSTALLDRMQGREAINMLRVKRHVENEDLSKDWVIGGVIVRKSAAKKSQKGNQFLIWTLSDLKDDLKTVSMFLFRKAYNDLWKTPEGTVVAVLNPNVLDRSQNSAEQASLSVENPDRVMILGKSKDLGVCKSRKKNGEPCTAFVNLSQCDVCTYHVKQEYQKYSRRQELQSSTMGKGLVNLQNKVLGKNTVIYGGKAYSALPTGNSSKVKERDNNRLMSLSDYHKSEGNKLMMNKAPLGAGSMKSSAILHSPSAQRTSDNERLNKLSASPNTSKSQNLTLAERVGSSPKLSSSGTFGLKGSGTIDLNMSYGQRAAERAKANAFRLIQQNGGLSKADPNNLKGTQAGKKRALEKLNGSSSDENDNQKSKSNEETSSQPKKMKTVMSERFKKILEATSAHQNLIQQHEDDEQEKYFSKLEKKEQMEEKMLNTFKLACKAVRCVKCKYTAFSAAQICKDERHPLKVLDSFKRFFKCADCNNRTVSLELIPQHSCSNCRSSRWVKAPMMREKNVQLAEGLSIRGEEETFIGGQVTSGKNINLLVPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ36</accession>
    <name>A0A835GQ36_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQ36"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="34527" checksum="3848C36A63E25EE5" modified="2021-09-29" version="1">MILQEAFAKGLLKPGLNEEIEVTQKNYVNNVADLKLKLKDIQLKLPWIETLDLVTAVAPMAPDVALQMQETAQRRKNLKENTKGHQVYDPTQDPVLNEFKRENLLHRQAQAAVVEGIKKLKDLGVPTRRPDDYFAEMAKSDEHMQKVRKNLMAKQAAQARTEKVRQLREQKKIAKRVQTDARLKQAADKKEMLEQLKRVRKGKSSDLGFLDDNKGSNKGNNKGKDGKGPQNKVNKRRAMKDKKFGFGGKKKGSKQNTRESSNNFDGFNGHAVQKKGNFKTKSFKVNSKKNQRPGKSKRKNNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQN7</accession>
    <name>A0A835GQN7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma</fullName>
            <ecNumber evidence="12">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HF086_004889</name>
        <name evidence="22" type="ORF">HW555_002219</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="12"/>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000190">
        <property type="protein sequence ID" value="KAH9642357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQN7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16201">
        <property type="entry name" value="EFh_PI-PLCgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13362">
        <property type="entry name" value="PH_PLC_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08592">
        <property type="entry name" value="PI-PLCc_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09932">
        <property type="entry name" value="SH2_C-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10341">
        <property type="entry name" value="SH2_N-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11825">
        <property type="entry name" value="SH3_PLCgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000051">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000004">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000009">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000011">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016279">
        <property type="entry name" value="PLC-gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035023">
        <property type="entry name" value="PLC-gamma_C-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035024">
        <property type="entry name" value="PLC-gamma_N-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000952">
        <property type="entry name" value="PLC-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 12 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="546"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="658"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="777"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="20">
        <location>
            <begin position="938"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="1057"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9421999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9642357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1201" mass="138623" checksum="A884C05EF593D643" modified="2021-09-29" version="1">MNPVCYNGGAHDRLIHEADQLISHIERGSMILKLYPRKRPERRSLSVRRETLQIIWARAGIPPKNMFEGALDIRDIKEVRLGKGSKHFERWAEEVKRLESSKCFTIYYGSEFKLRAASFAAQTDKECEAWVKGIRFLIEEAVNASYPLQIERWLRKEFYAIENAHENISLKEVKGFLPKINCKIATNKLRDIFQEVDTDKRGEIGFDDFSSLYQKLIFDENNVHDIFDKYSLYCKNGSTITLREFQSFLRVEQHDRLGDDEAVASQFIRDYLRDPQRDIYEPYFTLNEFVEMLFSKQNTIWDSKHDAVTQDMTRPLSHYWISSSHNTYLTGDQFSSESSLEAYVRCLRSGCRCIELDCWDGPDGTPFIYHGHTLTTKIRFMDVLRTIKEHAFVASDYPLILSIEDNCTLPQQRRMATAFQDVFGDMLVVQPFDKNETCLPSPENLRRKIILKHKKLPEGAEETSFSFRQEEVKDLDLRNSIKNGILLLEDPVDKEWNPHAFVLTESKLYYTEHYSNQQETDAESDGEPEAEAPVVPQEELHFGECWFHGKLAGNRQEAEELLRNHAHLGDGTFLVRESVTFVGDYCLSFWRQGKVNHCRIKLKQERGVTKYYLIDTVCFDSLYSLITHYRQHPLRSQEFLITLREPVPQPNKHEGKEWFHPFCTRARAEELLRKANTDGAFLVRPSEKDNSSFAISFRTQREIKHCRIKLEGRLYTIGTVRFESLVELVSYYEKNPLYKKVTLWLPISEELVRRIIAEPDDNTVYGTPGYMDPTAFTSKVTVKALYDYRARLDDELSFCKQAIITNVDKPDGGWWRGDYGGKKHHWFPANYVQEIEVPHIPDGPGLENETAALGSLQKGVVDVLGAVVELVVGEEGGAPRWLVRIQSPQMCGPFDMAAPTREIALEWLTAIKEAAISASARSLQHKKMERTWRIAKEMSDLIVYCRSVTFNQERIRNKGFIFNEMSSFPETKAERLMCQQETPFFLKYHTKQLSRIYPKGQRIDSSNYNPVPFWNAGSQMVALNYQTPDKPMQINMGKFKENGGCGYVLKPEFMFDEGYNPYVKKSIEKKVKPMIVMLRLIGARHLIKTGRGTTSPSVEVEIIGAEYDSGTKLVTKTVADNGLNPIWNDICEFEVSNPDLALIRFLVQDEDMFGDRNFIGQAVFPITCLRSGYRSVPLTNAYSEELELSSLMVHISFIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQW7</accession>
    <name>A0A835GQW7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">JNK-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_000199</name>
        <name evidence="9" type="ORF">HW555_002176</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000020">
        <property type="protein sequence ID" value="KAF9421956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000937">
        <property type="protein sequence ID" value="KAH9627814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQW7"/>
    <dbReference type="OrthoDB" id="5965083at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01212">
        <property type="entry name" value="PTB_JIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11801">
        <property type="entry name" value="SH3_JIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000032">
        <property type="entry name" value="Putative C-Jun-amino-terminal kinase-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000306">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="371"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9421956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9627814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49576" checksum="E70C857D35DA73CB" modified="2021-09-29" version="1">MADSEFEEFRRVFDRLPQHIKAPTPFYSLVPNVGLEDDSPSSKSECTPEDDTKEDMHPCMVDGNAATTTVKEEIASTPSQPDITETQRSPQHYAFTNGERKRRKLPEIPKNRKSKILACSQSTSLADELGQVTGVLVRPGCHTRPLLVLKCGYLLDEDSSPDSERLQSLGDVDSGHSTAHSPIDTGPKSISPTPLQQNVSPASSCSISGLNFAGNMTNIPHSQLEMLEATHRGLHKFNPRHHDEIEVEIGDPIYVQKEAEDLWCEGVNLRTGQQGIFPSAYAVDMDYNDFDPANAKDKKERYLLAYMGSVETSAHKGTGVVCQAVRKIVSECNAEPTMQPCILEVSDHGLRMVDRSKPARNRNGPCIDYFYSLKNVSFCAFHPRDHRYLGFITKHPTLQRFACHVFRGQESTRPVAEAVGRAFHRFYQTFIETAYPIEDIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GR60</accession>
    <name>A0A835GR60_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_000742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GR60"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000214">
        <property type="entry name" value="L-xylulose reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9424033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="473" mass="50852" checksum="0DA0EF704DE29EFD" modified="2021-09-29" version="1">MRKRILVTGAGQGIGRGIAVELWRAGANIVALSRTRSHLESLQIEYPSIDIVDVDIADWDKTREVVESLGHFDALVNNAAVAVCEPFLDCSPSDFDKMFNINVKAVLNISQIVARKMVENKTHGAIVNISSQASKAALKDHAIYCASKAALDALTRSMALELGPYGIRVNTVNPTVIMTEMAKVGWSDPDKAKDMLAKIPLGRFGEVSEVVNAVVFLLSERSSMINGVQLPIDGGKRILVTGGCQGIGRGIALELWRQGANIVVLSNQPDNLGNVKKEYPSIETVCVDLADWDKTREAIKSLGVFDGLVNNAGIAITEPFLECSPDSFDRTMAVNVKSILNVSQIVAKKMIDNKIKGSIVNISSQASQAALMDHTAYCASKSAVDSLTRVMALELGPHGIRVNSVNPTVIMTDMGRKVWLSDPLKSQGMLSKIPLGRFGEVHEVVNTVLFLLSDGASMITGVQLPVDGGFLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSC4</accession>
    <name>A0A835GSC4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_000563</name>
        <name evidence="8" type="ORF">HW555_005510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSC4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22042">
        <property type="entry name" value="HMG-box_EGL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000003">
        <property type="entry name" value="Putative transcription factor SOX-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="160"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="160"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9417413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9424424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="35678" checksum="2A981367D0BB6BAE" modified="2021-09-29" version="1" fragment="single">NIGNVTAELELQRLQQEQLRRQEMVRRGQHGMYPGPPLGLLPLLEQMRPQAQQPNAMQQQWPATAQLAQLTANTRSPPPQDPDTPLNLSKQRSPSPAQPMMLPRFVPYPPMEESQYSMPKEEEYNAACNTSSWSQSPSEDAEKAKLVRQPRRDETGKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNAEKQPYYEEQSRLSKLHMEKHPDYRYRPRPKRTCIVDGKKMRISEYKNLMRSRRQEMRQLWCRDGGSELGFLPPALASPGPSNSSPPPNGGNYMNPGFSPPLSPREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTG6</accession>
    <name>A0A835GTG6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_001786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTG6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="853" mass="95431" checksum="1F8A5ECBA2D9DB62" modified="2021-09-29" version="1">MTSADLTLIERLRKENLEQFFTLQFRWNFHKKTKNSSSNSSQNNTNITKNNVEVSSITEDGILRVNELIDFLSKPDNVTQEGIFRRTGSLSRQQELKNLLLTGTNLGLDEGKFSVHDCASVLKGFLAELPQPLLMDQYYQTYCTLAAQYPPNADSSEVKLLTALQLLLLLLTPSHRNFLQRLLRLLRLTADNEASNRMSPDTLATMFTPHLLCPRKLSPETFHADSIALSPVISFMIRQSSKLFDAPTQLVTDAAAYLTVREKRRAMSPLVDLDESITDKTAASTVYTFTDRSRTRAENATNPTDTALAQLYAHIQALPDSSHKRRLIKHFNRQNGYGTPIQIQRTGKVAGSRSFGDSIKRHIFNKGLLNKTPKKGSGSNINVIEEKSAKGKLRFTDDNKVDVSHKNIVLKNLAHKIASSESLDDDYDSDASNESTLSEGALNRSRKLSPKFVSEPNLSALDTNDETPKKKRGNRLFRSKIVTTQTLNKKYQKRNGVIRGTPTCVSCFDDQDTGSEHESYQETSEDKSPMDTPTKILQDDMKHYLTSTPGISDAVLFDEDFSTPYTINFRRASMSPITKSTQKLSKAMQESIMTPRSRKPLIITSEQRDMADTTVQKDETIKSDVIYQSMSPKNDSDFVSSDDDDVTRSTFSCERSRSSQSASTSLPRTNQLDARSINSIGDGSPVRPESTRFVLSRERPNLVDDLNTTLCGSDDGLPKFAISCETNEPTKCLSEPFREYLLSRSVLTATPIDLSILNKSNETDDKISDSLLYCLDGNVPSDLTLSISNLAVDKESSLRSPLKSICVNIDKSPNRKRLADDIGCIEESTSETKKLMVAKENIKEVFEIRETEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUJ0</accession>
    <name>A0A835GUJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_000191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="51"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9424890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="395" mass="45071" checksum="421289DDAD156A41" modified="2021-09-29" version="1">MACDYNKTNVRMVYTSSEELASVELYKCYPDTLLTITFACHLVFMLIGIPGNLTTIIALAFCRKVRNATAIFIINLHISDLIFGSMILPMTAVTFWTKQWTHGWIMCRVYAYCKLILIAVSIFTILAITINRYIIVCHPLSIYKRRNITIILIIIWILSSTLFLPSFFGVWGRFDLEPNLGFCTTLDDENGKSPKKFFASTAFVAPTLIIAICYARILWVVRKTKRILQGQGPKSMGPTHLPLTRTQSDTSTDGRTLISIDPASLTNSRTSDDLTPPSSATATPLGHKTFDNYFKATLRLTRKEKRPKSPTSRDKRLFAMIVAIIVSYTLTHLPLMVTRLIYKEYNSDPYANELAHLFGCLRTCMNPIIYVLISNEYRYAYRSLLENIMKKFRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUW9</accession>
    <name>A0A835GUW9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUW9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="227" mass="26244" checksum="58F4FE4C95F0B260" modified="2021-09-29" version="1">MRIEIQSETIFGPESIACIVKDIIELALDTFILESTYSYLKPHETAKIPVYFTKVERTGYHQCYYDLQFINTKTEDVALTKIVKVFAEVLPHPIKVHPLILDMSKSPVNHGYCEDIFVVSNTHKLYPATIKIKLTTKMKKIIYVEPMEATVAESSSVPFTVKFCSRDFLSVKPCEDLVHFTFKIVILGYKEVYENVPPYFYEVIAPCALEFKKVYKDKFSKEKDIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GV02</accession>
    <name>A0A835GV02_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tropomyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GV02"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000005">
        <property type="entry name" value="Tropomyosin alpha-1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="33"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36250" checksum="E03DBF025FC172BF" modified="2021-09-29" version="1">MKTNSMEEFWLASYRHEISSHSADWTTHKAATMDAIKKKMQAMKLEKDNAMDKADTCEQQARDANLRAEKVNEEVRELQKKLAQVEEDLILNKNKLEQANKDLEEKEKTLTATEAEVAALNRKVQQIEEDLEKSEERSGTAQQKLLEAQQSADENNRMCKVLENRAQQDEERMDQLTNQLKEARLLAEDADGKSDEVSRKLAFVEDELEVAEDRVKSGDAKISELEEELKVVGNSLKSLEVSEEKANQRVEEFKKQLKTLTSKLKEAEARAEFAEKTVKKLQKEVDRLEDALFNEKEKYKAICDDLDGTFAELTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KX30</accession>
    <name>A0A835KX30_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_013361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000630">
        <property type="protein sequence ID" value="KAF9406178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KX30"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="210"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="358"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9406178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="548" mass="61697" checksum="5DC6DB07C299F20E" modified="2021-09-29" version="1">MSTSSGTTSCDVVSVNYQPTRELNPVPEKDLEVNPVDYFPVDLSFPKRPPWDFNMTPAQLDAQEQRYFKNYVDGLQASQHWKNMSYFELNLETWRQLWRVLEMCDILLLIVDVRYAGMMFPPSLYTYIQEQKKDMILVLNKIDLVPSSVVAGWKQYLTTAYPALRVLYFTSCPSYNLRGVTSDKAGETILEKADTSFYSHERYKSGVLSIGCVGQPNVGKSSLLNALMGRCVVSVSKTPGHTKHFQTIYLTPQADTSFYSHERYKSGVLSIGCVGQPNVGKSSLLNALMGRCVVSVSKTPGHTKHFQTIYLTPQIGCVGQPNVGKSSLLNALMGRCVVSLSKTPGHTTHFQTIYLTPQPNVGKSSLLNALMGRCVVSVSKTPGHTKHFQTIYLTPQVRLCDCPGLVFPSTVPRPIQILMGSYPIAQLREPYTTIRLDMPKLLRIEHPEGDETWSPRDICDGWAKKKGYLTAKAARLDTFRAANSLLRMALDGRICLWLRPPGFAENREIYETCDEIKYIRWVQALTSDQEEQKSDVLTCFFLALDIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXH0</accession>
    <name>A0A835KXH0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000546">
        <property type="protein sequence ID" value="KAF9406816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXH0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8851" checksum="A759CDE0740B5F6A" modified="2021-09-29" version="1" fragment="single">ATLQERHEERRVWISITSELRDTYTDEDGNMQFKGYLLEESTSKTQQVSTNEMSTETLTKILESFAESKKESKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYZ3</accession>
    <name>A0A835KYZ3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_014330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000980">
        <property type="protein sequence ID" value="KAF9404446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="2">
        <location>
            <begin position="359"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="3">
        <location>
            <begin position="422"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="4">
        <location>
            <begin position="588"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="5">
        <location>
            <begin position="786"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9404446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="116436" checksum="35EFE8514F16E542" modified="2021-09-29" version="1" fragment="single">ILLYNLQHGRDNLRLGWNAAPLPTPRAAPRSRHAFPSAVRRLCFKKMGGKTLHSQARTLALKVLKYFEDEKSNKTYLIPVDKALKRACAATGISKATLLRIKNEAKKVPIISPDDDTVEPSPSTSEARPIPKLSTPGKKRKQRTNKIELDGNSERTKNPLEKEYWEKDRLGEMHQREFIISFGGEETSSSESESESENEDMMDGIEAISPLHHFPNPESHNMEDVARFSIWKSVLDVATQEKGNFYIYTNVRLCNNHFLECYQLPSQSERQSTRLILENEQLNSSVINPENSEQYELDVTTPIPDSEQPSTSSIAEHQLEGTTPIPDSEQPSSSSIAAAQKISMNKAFLKMIEKLPEEVQTFTKLQLKSTKKSKGRRYTTHEKIMALTILKQSPKAYALLKKMFVLPSKRCLQMMLNTCSLQPGINRDILIDLKNVAENLPEEKKLVNVLFDEVSLAPGLQYISSLGKIIGFVDLGYQRRKTLADHALVFMIKGIKNKSKQPICFTFCKGATKANDLKKILVNVIEEVNSTGLKVVATICDQAATNVRVVQELQKETQEKYLRRGEICYSNAVEIANCKIFPLYDTPHLLKGVRNNLISKNATFIHNGITKWAKWEHLKMLLDVDIGDDEIRLVNKLTEMHVVKEKIPKMKVKYAAQVFSQRVSSALRFLSKHNILPQECEGTADFILIFDKLFDSFNGHSYQGSPKKYKQCLKSNSPHFQLWNELLPILESIKFESIIKRNNCELIKHETIPSIKNWIHNIKTFKEMWQYLHVKYKLRNVLTRNFNQDPLENFFSSIRSNGIRNVNPNCDQFMNAYKTLLINNFNSVHSVRANCENDNSKPFQSIVNLLNKKPADLDLDNFACEIDTLLKTMLEIKNNDSLIHSESKKYVTGYIVKKIKSKIFKNCVICMNDFCRYDVDVQSFNYEVDYTKKSLFHPSEKFTSLMNDIYHAIVACLRDYPESCLLNKKIKYMINCACDYNVITCDQHKEVLIEFINDLSIKLIIHSWCTGVNRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZX5</accession>
    <name>A0A835KZX5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000346">
        <property type="protein sequence ID" value="KAF9409010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032899792" evidence="2">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9409010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="202" mass="21439" checksum="662FDDAA53021727" modified="2021-09-29" version="1">MMPRAIFLLAVLVLFEHTRAAPANEVSGSVKSASDSQGLNDDKDDLKTAASSGYAGDRYADWGRYPSGQGVTGYGSIDSRYHYGGFGGYDSPYGYNGYDSEYPRYGGSYSGYGSGYYGNSGYGSYGAAGYGGYKGGYGAGYGGYGGYSGNGGLNSYYGYNNPSYQGANHLGYGYYRRPGYGNIYNSGITPSLVTGYRGYSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1D9</accession>
    <name>A0A835L1D9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000232">
        <property type="protein sequence ID" value="KAF9411230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1D9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="78" mass="8287" checksum="4D96E279B1332B46" modified="2021-09-29" version="1" fragment="single">MMNEQADGRHQATKIQSSRPSPEIAAGADGSMTVARGDGSPERLGGALRRLHYKATRRAHSAAARHHNSNTTPPKVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1I0</accession>
    <name>A0A835L1I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_010495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000264">
        <property type="protein sequence ID" value="KAF9410414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1I0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090433">
        <property type="term" value="F:palmitoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9410414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="581" mass="64254" checksum="E6918304E690D3D4" modified="2021-09-29" version="1">MGEYVWRTYVDVEKEARHFGAGLRELGCQPRQNIVMFAETRAEWMIAAHGCFKQSIPVVTIYATLGDEAIAHGINETDVSTVITTYDLLPKFKKILAKTPKVDTIIYMEDPAQEHRKGGVYCKIKTKYTTLRSSEPVPPSPSDTAIIMYTSGSTGVPKGVILSHRNMLATLKAFADAMPIYDGDILMGFLPLAHVFELLAENLCMIGGVPIGYSTPLTMLDTSSKIMKGTKGDATILQPTCITTVPLIMDRISKGITDKVSRSGEFASAFFKWAYTYKQTWMRRGYDTPLLNKLMFARIRGLLGGRVRMMISGGAPLSPDTHAQVRICLCCSVVAGYGLTETTSCATVMDPHDRSTGRVGAPTSGTDVRLLDWDEGGYRVDNKPYPQGEIVIGGDCVAEGYYKNPEKTKEEFIDAEGRRWFKSGDIGELHHDGCIKIIDRKKDLVKLQAGEYVSLGKVEAELKTCPIVENICVYGDSSKCYTVALLVPHPLHLAELAARLGLPDMDFDALCQNPTVEKAVVKELADHARKCGLEKFEVPAAVKLVTEVWSPDMGLVTAAFKIKRKDIQERYKEDIKRMYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1I8</accession>
    <name>A0A835L1I8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_004270</name>
        <name evidence="2" type="ORF">HW555_009774</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000104">
        <property type="protein sequence ID" value="KAH9644009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1I8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044132896" evidence="1">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9644009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="12912" checksum="4F271572A783C6DD" modified="2021-09-29" version="1">MRFIIITAAILAMAQARPGLFFAQPYQPIGVQYVSAPSAIHPHPAVELNAASEAQLPRELLKSRDFYDNPHVAAGLAKESWFTNKEMQVVEREAEKIPRESIYHIVKSAGFLDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1J0</accession>
    <name>A0A835L1J0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1J0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="958" mass="105497" checksum="0877E5A5C6BCF4CB" modified="2021-09-29" version="1">MPITYNRGNVRKIAFRTRGRSAQSLDAGGPRVDPGGGGDGRLFLQIRPALPDPRAALAQRSHTTLSGNDFLQKEDSKDEIINLQAVGEGKVQLSRTPQEKDRLPDRISLDRRGLSSIPHIVGEPGLRLLSLQHNLINSLSGLSPLDLGKLVFLDVYDNQIDKITSLERLFGLRVLLMGKNRIKRIEGLNNLIKLEVLDLHGNRIGKVCGLSNLSELKVLNLAGNQIKCIGQTDLQGLVSLRELNLKRNRLRKLLGFQNTPKLQKLYLGNNDLQSVEDMSSLSEAVSLIDVSLDGNPVALGGDCVPFLVSYLPNLLTLSNMHVTEQVRRAAMAWRNNKEAAHAAYCALGGAAQQEARRDQIINNARTNWELLRSENKCFIPSTSPTKNVDIDKEFSIDATAVVTLPSGPEILAEGGALPDVVVSLQQADTEDSDCKNTSSDANVKTSTDIAPKASPMRKLQRSSTAKKPSERRVNFSDRSASQDTDASHSTSTSSDLRLPPILLPIISSLENVKLADSSEPILKRWESISSVEPVVDSSFSSLPTSSSDSEEDTKKRPIRRMATALRRRENFSTMRSKSVCDPESRRSKSKNSDISENASNISSSTNVGSVANSSTSGSDHNSKVLRREGSLNSRTSRNIRSATISRRNERASSANRASTARAKSVKNLNLANFKSSEPVPKSLPASKDREQGVDYLVEVCDGVVSAWGAGAVRRLARDWDWERARTVTRAAYHYVHYNAVAQSLPELKSKFPNVSHISVRATGLQWLGQLHALAELRGVTGLTVLPEGNPIYTKIWREYAIYRLAHWGLKEINDEPVTDEEIKTANRTYAGLSDIVLRAIPDAPLQPLLSRLGRSGNSAVSAKAWLRAADPALRDVIAKEALQYKKGNVSQEDMSWRVRGRGQLSHAIDLACGAAQRLRALEVQWPTILVEMIEDILRDFANMETHVKEQMKMLMDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2M9</accession>
    <name>A0A835L2M9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000624">
        <property type="protein sequence ID" value="KAF9406229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2M9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="572" mass="63706" checksum="134B2EC1C23E30E5" modified="2021-09-29" version="1">MSAQKALPLTKEEVMMLVKLVEAHPVLFSKATNATNNRLKEVTWAKLTTRFNLMISSSPRKPEQLRSKWENLKKAARKRSQIRMNNLKTGGGNPDFTPPYEALDKVASILRASCDSHRVPFRGTLKHSVAATESKASVIARNRAIAEYYVTKKKNESELAPLKKRKLELEILELEKRFCCDPSFFLLCFALALLFEVFLFVAVGAVHAIPPVTGSNVEPIWGEIALLLFGDLFGLLLLNDLSGLLLGDPVSHLVFLFLGGLMSLSLSRRLEALGLSESFFLGGEWFFLLGGLISLSLSRRLEALCLSESRFLEGEWFFLGGLKSLSLSRLLEALGLSESRFLDGDWFFLLEGLQSLSLSRRLEDLGLSESFFLDGDWFFLGGLMSLSLFLRLEGLGLSVSCFLGGDRAKLFSLFDFFWPVINDAHNLGRILTLVKHIQLITFHEDAEAWSSLRPHQCLDTALLLTVSKGTPPIQTQTPATTHLTSSPTDRGTLRRLRLTGVPYQPASLHPTHWESAGSAVDSKAIAAQFRHTEIKGNLHWLWHRSYQASTAVSAGSPSNLDLNQISYSLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L341</accession>
    <name>A0A835L341_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000531">
        <property type="protein sequence ID" value="KAF9406910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L341"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="314" mass="36214" checksum="AB828D99F9B947F1" modified="2021-09-29" version="1">METERQKFYKHKIKRILTKDDASSVIDENDKSTVTLLGSTSYHKKVNDFSIMNSSNTDQQSETLLDDKVEPNFHAITVNETKMTDENVSDLKDRDIIINEVIIEVEREYPEEIDKSEVIQIERTVSNDSLQPTITDIIPEKDMDLLRKSLEDDKADDNGQLIPTTDDHPIRQKNKRVVLKKSYVDFLSEDEDFAWDSTSWKETEESSSDEDNNEAPRKKNKKIIKDGKVGDAGVKKKRINRKKVQKESRNKGAQYVKADGSIVKARNMKPNPCVEKACPYKCQEITTEKRSAIFEHFWGLSAERKKTVDSIYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3F8</accession>
    <name>A0A835L3F8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000165">
        <property type="protein sequence ID" value="KAF9413288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3F8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF6">
        <property type="entry name" value="OSIRIS 19, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032934657" evidence="2">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9413288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="179" mass="20440" checksum="05C51B8ECE8C653B" modified="2021-09-29" version="1">MNALQPTRILCFFALFLIICAASAHSVPKHDHVEDERFEVYDGVFVNIPKDNTTGRMLSIDVDTEVSEGRLNLYPFYELCLITNFFSFSGRGKKKNIMQRILPMFILPFILQSSIMPLILGMLKFMLIKSFLVGKLALTLIMINAFKNHNSFKGRDAEVASHHYGYHENGMEPIATYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3K4</accession>
    <name>A0A835L3K4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000157">
        <property type="protein sequence ID" value="KAF9413496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22307">
        <property type="entry name" value="Adgb_C_mid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053033">
        <property type="entry name" value="Androglobin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054093">
        <property type="entry name" value="Androglobin_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054094">
        <property type="entry name" value="Androglobin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057249">
        <property type="entry name" value="Globin_CP_ADGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46298">
        <property type="entry name" value="ANDROGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46298:SF1">
        <property type="entry name" value="ANDROGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22068">
        <property type="entry name" value="Androglobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22069">
        <property type="entry name" value="Androglobin_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52042">
        <property type="entry name" value="GLOBIN_CP_ADGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="1">
        <location>
            <begin position="626"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9413496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1453" mass="165307" checksum="A3FB7E3C909C6A84" modified="2021-09-29" version="1">MEDTRQNPSMKQSYLGFTSFLIDYIMVTPKMSRKALENMKPVVAEVVPFECPFREFRDNELQIDTWGLGPAAFRAHYYVVKAAVKTSHEPPIWIDDQTQPLPRSAQHFLHGWIRAEDLAEARWNAEVLDNDGGKMAISDIQLSHTQVLFRSSFCREVLSACFILERVESLAIEHQWEMFSCSFGQEGWRPKYHIYSPGTKPGGGTQHKPTLSKNGCYLVRLFYLGAWRCVWVNDYVPVDSNGAPLLPFSPLMTHPPGKPGSKHVPPAVTASVIYLWPLLLTKDLWTRITSEVPLFSWDDDDETQPSTIKSRSTKKSTAKELANVVRRNSLTYIDLVDTKDCPPYQLPGITPGHEMNLLVTMARDLPLKKPLPEPEVALWKYYRWVDWAKRHGLYAMYACPRTRFLKVNGLMKLSYAPHLLDVQSTESITYGFIEEHGMEDTSDNKKKKDRKTKDQTKSAMNAAAALQAQQMKEELREWVQFMELQSLVKCLHVLFYPSMFNFASAGSNPPLRLPTAKGAVPKATDITAPKGAPLYFQLDGPEVNKIKISLSSLHPRVLANCGSRIPDHIEKSYVVLEKFEWFNDAELPVPSGFATTRRYQSLELDYPPGRHYFRVWVHARVNWSLMVISESTLLLGTKDVIQGAAVRDCPWASKFLSNLGLAFLNWTKVVRSTQNVMIQADREFFSSYAPDLPWDKKVVGYDPHLRHWMFRQALQSRLQKCLGQTEWKQVVSVLRKYFCDPNFGFTEKPRPVKSLRNIADLEVCDCVMPEVEETEIYEEQHLEETEMVAEDEKPLVDSTMMAQLLTYPEPPIISQVCELATDQIQCGLLKEEREKVISRHEAAIAIQAHWRGTWARKCLNSTATFTPEILKYVQDQAFGTVDSLSMLMNEFFTMFPGAKYAYSVSSALSGVYGFQQHTGTTPVFPKCVWVPYFQGVFYCHAPVKVHFDVHSNLGHSMLAVYDNDTSAQLPQAFNSHVTYDFNPNVFGYTVVGHGTLNRATGINQDAHWQLTVMSNIDGAFHVCDNEDPCKALHIPYTQKIHVDEIFFPNRRNILGGIHLSVTKHESVSFRAAASSPEVEMVAILRTTLPNGESVELGKCAGKGEIYWPFIRLEPHVVATNSSTYTSARDLNVTSARSIFKTGKQRKVSPPHKSSHRSLGKIKQLHDSKFYSIEVTCPSGWPLTLAQWKRVDEVINSIEFTKVEQLQIQKKLAKEKEKPTKIMSAKEKERVMPLNFGVHQPLPGDAFVELECAFAVGGGVVAKRDDERDQNFVNARKAWDAREHGRNARGAQIRKQFREEFLVIPPPEISESTKSGLDSSIRSSNMDTDVMDTLSKMSVEAEEEAVYLTMPELLRDNFKPLNFLPLCMKEKESYDSVIVTSDMAKAAAKERQARIEAAKERMKELQLYNEEHVLGRQKDRCFALEKLFVDANMCPELMDVMEQRETAIQEEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3Y1</accession>
    <name>A0A835L3Y1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pleckstrin homology domain-containing family J member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3Y1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13258">
        <property type="entry name" value="PH_PLEKHJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF9">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00041004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="346" mass="39383" checksum="FC01069A2DF0398D" modified="2021-09-29" version="1">MKCNIRELAQLSDQPCVIEGRLNYKKISNGSYRNQTVFKERWFRLINNYLFYFKISEMGKFDTKCPAGMFVLENSSIQMEHGQSIPFSFSISFIDEPEKRHVFAARAEDNVVQWVMKLRQSSYEYLRNRLHALQSKIYAITGKDPLLLVPRNEGACLWAPSVPFSTAPACTVNTSSFSCHLHTNGAFTLERSKSDVQAHKHFHAEYSQKSTFYTDDYKKVTEKREHSNEVYSLERSKTSALLPGSANPIDKTIFDNRPLYSRAAPSPPVRTKLSPSSRRVEINQDVKVFAEQSRNLGVTGILDEAPIPPRRKVSPKNLEIQNPTIEITTNSASTIVDDGSDDLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4L5</accession>
    <name>A0A835L4L5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticular protein RR-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_010774</name>
        <name evidence="5" type="ORF">HW555_007272</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9415005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000946">
        <property type="protein sequence ID" value="KAH9627622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4L5"/>
    <dbReference type="OrthoDB" id="6515429at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032523511" description="Cuticular protein RR-1" evidence="4">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9627622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14430" checksum="B4D4A4EBF62CD4EE" modified="2021-09-29" version="1">MMRMKMHQSPISHRTKLTKMKSIILVALALVAIAVAAPSDPVPQILRSDFKQEVDGNYQFGYEVDNGIVREEVGEVKEALDEENKPHKVVTVRGSYSFPGEDGKPISVSYYADESGFHAEGDSIPKPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L514</accession>
    <name>A0A835L514_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L514"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="78" mass="8849" checksum="01273193A596A5A4" modified="2021-09-29" version="1">MDVDCYIVDIASNWPKKFVPEKVSHSNRTFFNEDKHIIEEHISNGFSKTCSTFFSETSGLGMTYCTGLIETHFVAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5A0</accession>
    <name>A0A835L5A0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000098">
        <property type="protein sequence ID" value="KAF9416010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5A0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="11313" checksum="C2992784D59A47CC" modified="2021-09-29" version="1">MKDEDNNTVKLAGLKMVKVQSSDPDAIFFKESYADEVFKKAIVVRKKRYHNNPTINLDLQKAYLQKPGLAERKKADLMDLVNKNLIPRYHKPFYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L666</accession>
    <name>A0A835L666_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000101">
        <property type="protein sequence ID" value="KAF9415814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L666"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="213" mass="23769" checksum="89391066734D81CE" modified="2021-09-29" version="1">MAASINETCMFNEQCEDVYFKTECRNERCACKFEMVPEVTVDGSVICTILGHKTLISSCISKKVHFRRIDRSTVKPVEESTRTLDPAMIGVLVGMALMFVIICVVLRLFSRARWRENRTIFNTPNPRLMNVSLLRDSKLLHSQDRRGSRVSVRPPSRQASQQELRPHSPGPGSRRGSRASSGHSATSLRSATLRSPTTPGPTSVTVEIRAPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L696</accession>
    <name>A0A835L696_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED15</name>
        <name evidence="15" type="ORF">HW555_006637</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L696"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048385">
        <property type="entry name" value="Med15_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019087">
        <property type="entry name" value="Med15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21538">
        <property type="entry name" value="Med15_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09606">
        <property type="entry name" value="Med15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 15 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit central" evidence="13">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="14">
        <location>
            <begin position="563"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9415885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="696" mass="74045" checksum="6C7CFB5477955F65" modified="2021-09-29" version="1">MASDDNWRTSAFRQSVVSKIEEVIQRSGVQVARNSSEMENHVFLKAKTREEYMNMVAKLILHVRELSQSKQNQGQQQMQGPNQGQAGPNPQVQAPQGQPQQGPNNQGGLTPDPINALQNLASQGSRNQMMTMGPQGQMQQQGVMGPNPGMGGMQGQMGQQGPIVSQGPQAQTATSLLQTLNRPQMNMQLQNKLGGPMGMVSNQGQMGNNMVGGMGGMGNPMGSQLQNQLAGGMQGQMMPNMSMANSMQVPMSGSNTMGQMPCNQVGMGGQMAPNNMQGQMQGQMVGGMGNNQIVGLNMLHMGRVGVGNKQEVGGMMAGSYQGARAPPPTQFLRQSPSPSAPSPSMGGPSPMGVMGTTMTSPMSSLGGLGACGSVGSPSPSNPTHLQHHVQQPQRGVGMGMVASPSSSLNTPVGASVASPGGEEAAYREKVRQLSKYIEPLRRMVHRMVSEGENVEKLTKMKNLLDILSNPNKRMPLETLIKCEVVLEKLDFKRGEGVVVPSTGKEQIFNPLLEVVNNCLQSPLANHTLKRTFGSALDALNGPEMRNLPTPQKVPKLEEPPMEIPDVLQGEIARLDSRFKVSLEPMSWCGGSGGAGGGAITLVAALDEPRLPCVAGVHVAVPRDYPARPPVRLKPRSHHNYAPDSFLARLEKAMDARCARLPKSCSVGQLLDAWEMSVRQACAPTPVTYAPVPALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6H2</accession>
    <name>A0A835L6H2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran-specific GTPase-activating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ran-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_005479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1. Identified in a complex with nucleotide-free RAN and RCC1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RANBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000072">
        <property type="protein sequence ID" value="KAF9417382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6H2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000824">
        <property type="entry name" value="Ran-specific GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF94">
        <property type="entry name" value="RAN BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9417382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="226" mass="25864" checksum="404E12BD09625D38" modified="2021-09-29" version="1">MYGQTEESVRRNSESEGGEAETPEHDPHFDPIVSLPLVDVHTNEEEEEELVKIRARLYRYDTGDHEWKERGTGDIKLLRHKVNNTVRVVMRRDKTLKVCANHFITPDIRMNVHCGSDKAFNWSVFADFADETMKQELLAIKFGNAQNAELWKTKFAEAQEIVRTKCSIYTQDLSSDDESSITRSEDTDSPEPKPKALEKDAKNDKEEAEPEGVVLKLKELKVEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L799</accession>
    <name>A0A835L799_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L799"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="122"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="337" mass="37733" checksum="67B6804DB9979AD0" modified="2021-09-29" version="1" fragment="single">ICETLLGSLFVHNKYREAVADTYQNRNAKESSMEGDDVAYCMPEGPVFQRAYVRVHGYIALLICLLGSAANSVNIAVLSRKEMISSNEFHPDRTGSRRLARHDRLHSPGATHLYRYIQTFHTISIWLTITLAVWRFIAIKFPQKNRTLCNKKNTNIAIAVAYAVCPILCLPIYFAMKIRVIPSKHGHNNTTLHDTDVVSNVTESKEPEYAIVMTENDELLTAIFWIYSVFIKLIPCVVLSILSVLLILKMKSSDRRRQKLLKKSAIASNEGEKARLNEDGGKRGGGGGGRTDRTTRMLVALLGLFLATELPQAIFGLLTAIAPHLFKVCYYAFGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7H9</accession>
    <name>A0A835L7H9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_018017</name>
        <name evidence="2" type="ORF">HW555_005317</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000068">
        <property type="protein sequence ID" value="KAF9417610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000930">
        <property type="protein sequence ID" value="KAH9628042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9628042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="94" mass="11023" checksum="810B4A082C8A4D7F" modified="2021-09-29" version="1">MAHQFWISYHPPTGNKHASSGDETPPIPEEELEQQKLEHEKQLQKEKECQAREAEEIRQLDIKLLHQRAIEAEEDKKREVTVSIQCVQYNMLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7Z8</accession>
    <name>A0A835L7Z8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Signal sequence receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_003850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7Z8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008855">
        <property type="entry name" value="TRAP-delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12731">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05404">
        <property type="entry name" value="TRAP-delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032765375" description="Translocon-associated protein subunit delta" evidence="15">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9419572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="167" mass="18102" checksum="9DE357EFBE6A882E" modified="2021-09-29" version="1">MVTKYAICLFAIATVAFAQGCTNPQVEATSFTSLDATVVTQIAYITEFTLKCDNPLPENYALYAEVEGKPLTAARVGENRYQVSWTEEPAKARSGTHDVLILDEEGWANLRRARRADPAAAVAPLIAIQLHHPGSYSGPWVNSEVLATALSILVAYTAVRHKGKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L851</accession>
    <name>A0A835L851_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000039">
        <property type="protein sequence ID" value="KAF9419767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L851"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="162" mass="18071" checksum="FE42F3C0E2191F28" modified="2021-09-29" version="1">MIKRCAVHELEESCVRQGGLCVMKSDCPPENIVFLSGTLCPKQQHLGVTCELNMTAADSIRKQITVHEPQPDDRKTNNSSWVGCNRVVIFYVRFFYNRPYLPQNMSASSKIARGIKSRATNRCALISSAPNAAGERAAPRRPRAHPLRPTTRSTLCPAYNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8J6</accession>
    <name>A0A835L8J6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic receptor 75a N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8J6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF32">
        <property type="entry name" value="IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9420400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="658" mass="74778" checksum="38CA1CF2CC62FDF1" modified="2021-09-29" version="1">MTIHCTVRPTLGEMILLTLCCLFLTTFGFNLNVSNFIADYVLYKDLRYLCYFTCQNQYYNNILVHKLTKENVRVSVRRLDGDGDIDVVRVAHQTTMPVGVLIDGHCDQTQALRLQASRNKLFDAVHPWLILTDIEDDNCTEYVMQTFRLLNLSVNADVAVVTNRGDSFTLIDVYNFGRIQGNNLETALLGNWQPDRGLDIVLKGYKYYNRWDFHNLTLRAITVIVDQPKMFYPEMLSEMAYTAGVAAMTKITSQMLNTIKERHNFRFNYSIAGRWIGSPERNSTMAVTNTLFWEEQDLSSTCARIFPKWLNWVDIYHPPTTNLQTKFYYLIPEKGVGQYENRFLTPLSHGVWCCAFFAGIACTLVLAGAARMEDRPKPELYAFFSVFAAVCQQGYEDGVQLLEQTISSQGRRLTLLVIGLTSMLLYNYYTSSVVSWLLNAAAPSIANLDGLINSDFELVFEDIGYTRGWLDNPGFFYYSGFKNVKEDELRDKKVTKAKRTVSVLQNVNKGVELLRTGKYAFHTEPYTASQVISKTYEDKELCNLGALQMMLPAHVYIMAQKRSPYKEFFDWSLLRLLERGHVKAIRARFAGTMPACSGAQPRALALGQAAPAFLMLAAFAMLSCFILSPAEKPRPMRDTQKVTSPSDQPQIAAHHTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8P7</accession>
    <name>A0A835L8P7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8P7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032360076" evidence="1">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="200" mass="22094" checksum="364E565084105F40" modified="2021-09-29" version="1">MFSARICQRLVVVYLCIASVFSAPMQLPFLPMQYGMNAQLPFLRQMTPNLQSPALFPQQQPLVIVLPNATPNGETDDRYVNLNEQLEANLKSAGHVDENKDAVVIDANDPKAPEMHTKNAVVYLPNEGRYSIGQIISYIPFLPIEINVPDTISWITHLLTGGIFRPGPAQAPVGTKTLPNKPQVPLIVMPYPGLLPNLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9H9</accession>
    <name>A0A835L9H9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-beta-hydroxybutyrate dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9H9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33959" checksum="4F7AB3C7E3DE24BA" modified="2021-09-29" version="1">MSIMRVVAITGCDSGLGWAIAARTAREGIVTVAGMYNGVDTKAAESLKKLSAHTYSLDVTNPESIAKFRDYVKRLLNDNPNYKLHAIVNNAGVMIIGDYEWQTDSMVENTINVNLLGTMKVTSAFLPDLRQSAIQNKGASKPRIINIASHCGLQPLPCFAAYSASKAGVLALTKALRMEHRKHGLSAVAFVPGGFVSSSNIIANQGQQGKNMLEHLNEEQKSYYGQRIKTLSNYLQLATAHDPSYDSMKDENIIETYVKALTDDDPKQMYKVESWRYFFYYNLLKLPLPEAFIGWLVKKFLCFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9V1</accession>
    <name>A0A835L9V1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000100">
        <property type="protein sequence ID" value="KAF9415887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9V1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9415887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="36960" checksum="238CE0D7B97A008F" modified="2021-09-29" version="1" fragment="single">MFDRYQVHYFCLSFLITMADIPSTSSGLIHFDFVTSKRGGRVLLLEGHQYYQKKEYKNGSSYWRCVNWPKCHGTTTIMLTENKIMKSTVHKCQKSIAKNEVRKAISICKTKVSEDFKKTIPTVYREAVISLKDASDDTIKEFPSYKNVKSNLYKKRNMAVGVKKTRYAIATDVEVPDIFQNIPNWDPMKFTVDFEAAVMSTLEEKFPEASIKGCFYHFNRAIWKKAEQLNLSKNKITRKHVALLTVLAHLPPEAVTDGYLYIMEDSPTDEAVTKFNDYFVKQWFENNLMKDKWCCYGERHRTTNKLEGWHAMLNRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LA42</accession>
    <name>A0A835LA42_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_001810</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000448">
        <property type="entry name" value="Toll-like receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000355">
        <property type="entry name" value="Toll-like receptor Tollo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033036120" description="TIR domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="18">
        <location>
            <begin position="1024"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1185"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1185"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9422606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1294" mass="146635" checksum="EDC6F60A404E6FB0" modified="2021-09-29" version="1">MYAITAVLCALVHVGSTVLPYGSDKCVRVSDRGSDGGVLCRIRTLDGDGSSIVSVNSDTSRLAIECNHLLLFESSLRAHYFSPVSALTDLTISNCKLLQIPDNTFHELKKLKKLKIRSKNFEWSPTKNLELSLNAFNGLSELQSLDLAQNNIKFVPSGVFCSLENLSTLNLTHNRIRTVGQLGFGQGCGSNLHSLDLSHNEIKSLPEDSELLKLRSLQHLYLQHNNISDISSEAFNGLVSMRVLNISHNHLHTLPDGLFANARELREVYLNDNTLFELARGIFHRLEQLIVLDLSSNQLTSSHIDDGTFLGLIRLIVLNLSNNALTRVDGKTFKDLFFLQILNLKNNSIGYIEDNAFLPLYNLHTLNLAENRLHTIDENLFNGLFVLSKLTLNNNLLVNIDRKAFKNCSDLKELDLSSNQLLEVPDALWELSFLKTLDLGENQISDFKNGSFKNLNQLTGLRLIDNQIGNLSVGMFWDLPSLQVLNIAKNKIQSIERGTFSRNMQLEAIRLDGNFLSDINGVFSTLASLLWLNLSENHLVWFDYAFVPSNLKWLDIHGNFIEHLGNYYKLQDEIRIKTLDVSHNRIAEISPMAIPNSVELLFINNNFLNNIHVNTFFDKKNLTRVDMYANELVHLELNSMRLATVPANKSLPEFYIGGNPFQCDCTMEWLPIINNMTAMRQYPRVMDLENVLCKMTNTRSGTHVPLTNLKTTDFLCKYETHCFAICHCCDYDACDCEMTCPQNCTCYHDPLWNTNVVDCSGQSSMEIPHKIPMDATEVFLDGNNIKELQDHVFIGRQKMRSLYVNNSNVDSIQNRTFAGLNALQILHLGNNKLKELKGYEFLQLSSLKELFLQNNLISHIANISFLSLKSLEVLRLDGNRLVDFGVWTFNNHPNLKALSLGNNLWSCKCRYLQELTAYLAENAQKIIDITDVWCWNGDAKPPQKKELNLNGTACSDYYADNSVIGNMLVSNYVPMMVSTLTGFMLILLALVVLFLFRDSLRVWLYTNCGIRVFSFSGAFEESQKLYDAYVCYSPKDEESVVQSLANELENGNPSYRLCLHYRDIPHHGAQYMQCAPPVVETAEASKRIIIVLTRNFMQTEWSRYEFRQGLHDALKGCIYKLVLIEEYSVVADAMCDPDLRPYLKTGSRLRWGEKRFWKRLRYMMPESQPNHKARSHSYRKSLNTYTLDSSVPNGGNRTLPFPERSPVLGGGQGASAPPEYSSEVRQSPSAMRQTQAVAYGPDGRPISDHIYSSIDSDYSSLEHGMAPGRRRDMRQWPPPPPLVDTGNAVQAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LB16</accession>
    <name>A0A835LB16_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_001620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JACKWZ010000013">
        <property type="protein sequence ID" value="KAF9422836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LB16"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="192"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9422836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="325" mass="37815" checksum="C5F8D55835AD8FBF" modified="2021-09-29" version="1">MGFEKPSVIQQKSILPIMKGRDVIAQAHSGTGKTATTSISILQSLDMRLRETQVLVLSPTRELATQIQKVILALGDFECPMPCLYWWHKSWQRYQEAGLWPACGFWNTRTNMIRRRVLRTRSIKMLVLDEADEMLNNGFKKQIYDVYRYLPPSTQVVLVSATLPHDVLEMTSKFMTDPIRILVKRDELTLEGIKEFFINVEREEWKFDTLCNLYDTLTINQAVVFCNTRAKADWLAQKMIEVNFTVCSMHGDMPQRERDEIMKMFRSGQSRVLITTDVWARGIDVQQVSGHQLRPAQQPGAVHPQDRQIRSLWSQGSRRQLRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBA3</accession>
    <name>A0A835LBA3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBA3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9424312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="332" mass="37136" checksum="11A0A9E660E7B1E8" modified="2021-09-29" version="1">MSIVGTFISTRHYGLLSHSLSVPPKRFYICVKTAADGKSNIICITSIGTPDGQLFKINENINDPKSLTESSNKTLDKLLESLLEEKQKKSETQNLGKIAKDLVLEKFTGKNANHSPITNQSLTNELRTSTKNVNVSILMKTGKKLKFKKDVNWYSCMLIKFTVESEWIKWEKNFCETFGNKGWSPIRYALGFKYQSGSLLEYALKKEKLLLEVRKTIDTGTLIDLIAAGLPNYLSDKIDRETLQQTEDLYNEIGKLEHLFDTTTACSLFSAFDAVSVYSGGDAVISRLKQQTVTPAAAVCVTGEAQRLILYLCAPRAPFTCILNRTALYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBS8</accession>
    <name>A0A835LBS8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBS8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF53">
        <property type="entry name" value="CERAMIDE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032778295" description="START domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="130"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="338" mass="38531" checksum="30945E296BF2C877" modified="2021-09-29" version="1">MHRRQGDLFTLFLWGLGTREWFGDVIVTSPAKGAPPPFSGNPNHPAFHEGPHSTLPDDEFYDAVETGFDKMEEERCARVVPPSVHTRDQVELPPPAIDNRLTVHPLWPEIDRISTEQIQAAFEGVGGEIGWQLFAEEGDMRMYRRYVETDSQSGEMEVDGMVTDPLKAMHKVRGVTAREMCHYFFNPRYRYEWETTLETMTIVEEIASDSLVFHQTFKRIWPASQRDALFWSHVRQSSENTYAVTNHSTTNADYPANNGACIRLFVTVCLACHTTYPAGEQPTRDNITTSIAYCSTVNPGGWAPAGVLRAVYKREYPKFLKRFTNYVVEQCRDKPIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LBY0</accession>
    <name>A0A835LBY0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_004655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LBY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032972036" evidence="3">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="432" mass="48254" checksum="72D31002AC17525A" modified="2021-09-29" version="1">MAVCDKWVALKIVEFLMCVACLVTKRISQDDEARLALLLQKLSREWSLLTSVTWDSVGGAFADAIYGGYVIITFGLIMARIFQEIPKGRRILEGCFLGFGMLFFLILGGLELASLDSVPRSLVVNASVLGSFSLVVAALFLIDLMGPRIYTTTQNSQTDTGIVSSPKSEKKVSIISSPNLNGNLPKTDLANGKTNGQPNGHVNGHVPLERPKDLDLEKNLPDKDTKKEEMTLFAQSKTSYPNIVDTLEKDELQKSKFGSIRNGLEAGNYVRLNEPLSIPDKFHYEQELAKFNEKYLRDYLDNFAGKLSVREDYLPEPQTPVFAKVKTGRLKDLYDEMSPSYEQKRSKSPTRAKTVPSPTLQQLEDYLRGSTRSKRADTPALFPMEPIEEKETTDTEGRASGTPTDPGYVQYTAGRWPDKTRDLRTPRHSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LFB6</accession>
    <name>A0A835LFB6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Organic solute transporter alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LFB6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9422967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38171" checksum="DF312F74D5C27CDC" modified="2021-09-29" version="1">MLYLLKTKSDHILIFINNLNNIIFSSTALQTYAWVIFACGLAVLLVICALYVITLRSAVKHWRDQMHHVAVVLSIYPIVAASALVMIVVPRSRLPAEAVSQEAVMVALYHFFCLVIAECGGTEQLVRSAGGADLETRVMPCCCWPCCVIPRPKLHKASLMWLRCLVLQIPIVQGIIYFILIVIWSEDFMLYQSIFVYFQPFVAASILSGMWGVVMCVRAAISVGRAPRPRFLVVQLVLIIVKLQCGLAKSVPNMANLSCVMNLHPAVFASLINNSIMMLEMLLISIWAWRVYSSPPGKDMEKVQRDRVVVAVLEDNMRSIEVKSIKDGIDNKSFNNNVPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G057</accession>
    <name>A0A835G057_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_014165</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000880">
        <property type="protein sequence ID" value="KAF9404791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G057"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001979">
        <property type="entry name" value="PRK00768.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="NAD/GMP synthase" evidence="16">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Divergent 4Fe-4S mono-cluster" evidence="17">
        <location>
            <begin position="761"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9404791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="825" mass="90323" checksum="E9A532B444B9BCD2" modified="2021-09-29" version="1">MEEMRQETKNDAYQFIAVRLPYGEQADEADAKKALDFIQPDVSLRVNIKPAIDACTNSLAEATVSISDFNKGNMKARQRMIVQYAIAGEHAGAVIGTDHAAENITGFYTKYGDGGADILPLFRLNKRQGKALLKELGAPAELYLKIPTADLEDDKPLVADEVALGVTYDDIDDYVEVEKKPQTSDLRIPDNIKGLSDHEVQQRYAEGKEIHAKKTIDKLSLVNKTEVTVLRENRLVTVLQDEIVLGDVLVLALGNQVPSDGVVLHSESLEVDESLLTGESDKITKQNGDKIMSGSFITSGLGYVQITAVGEDNFVSKLSKEAKTEKKSTSELMNSLNLLIKGLTFAIVPIGLLLFWSQYQSTQSFPKTVLGVSGALISMIPEGLMLLTSVAFAVGAANLARKQTLIQRLSCIETLARVDTICLDKTGTITDGTLTFKELIPQAGFPASEIEHAVGEMMIGLSDQNATAKVLRSQFPLQQATWKVKDIVPFSSERKWSGVSFEEKGSFVMGAPEFIYSDVPEALKEILEPYNEQGDRVLILVHFNDELASSGLPQAKETVAIFIIADTIRENAVDTFSYFVKQDVTLKVISGDNPITVSQIAKQAGIAGAENFVDMSKIKDDDNFNDLVEKTTVFGRVTPYQKRELIQALKENGHTTCMTGDGVNDILSLREADVSVAMASGSDAARAVSDVVLLNSDFSSMIQVLNEGRRVINNIERVASMYMLKISMCGLNKGGKTMDGSKINGKDVTEEQLIEEGYRKYSGEKLAIYYSKDICEHIGNCVRGNPDVFEVGRRPWIIADNSNAEDDIQVINTCPSGALKYIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G179</accession>
    <name>A0A835G179_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="6">7.2.2.10</ecNumber>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HW555_014305</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BAW_Kor-Di-RS1</strain>
            <tissue evidence="23">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mg(2+)(out) + ATP + H2O = Mg(2+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="6"/>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000956">
        <property type="protein sequence ID" value="KAF9404516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G179"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF9404516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="49410" checksum="2F5AE0E1C7988C92" modified="2021-09-29" version="1">MTDLKKNTKDQELRKLAMLPERDLMMELRTSENGLSEEDAKNRLEEYGPNEVSAQKPTPAIIMFLEAFKDPFVYVLALLMVVSAATKDFEAAIVMSLMILASVVIAFIQEYRSQKASLSLKELIENTTAVTREGVTKEVPMDEVVPGDIVTLATGDMIPADAVLIWTKDLFINQSSLTGESMPVEKFVEAGVDRNQENVSALDMQDLVFMGTDVLSGQGKAIILKTGQHTFFGDIAKNATTQRGKTSFDIGLTKVSKFLLRMVMILFPIVFLINGLTKGEWGDAFFFAIAVAVGLTPEMLPMIVTSNLAKGALSLSKHKVIVKELPSIQNLGSMDVLCTDKTGTITEDRVVLVQHLDPMGNVNDNVLDMAFLNSHYQTGWKNLMDIAVINFHEENNVESPFKSVTKLDEIPFDFSRRRLTVVVNADGHQLMITKGAVEENGSRLYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1I9</accession>
    <name>A0A835G1I9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_014127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000864">
        <property type="protein sequence ID" value="KAF9404871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1I9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1700.10:FF:000002">
        <property type="entry name" value="Diadenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="entry name" value="DNA integrity scanning protein, DisA, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.40">
        <property type="entry name" value="YbbR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050338">
        <property type="entry name" value="DisA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00159">
        <property type="entry name" value="diadenylate cyclase CdaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34185">
        <property type="entry name" value="DIADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34185:SF1">
        <property type="entry name" value="DIADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DAC" evidence="10">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9404871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="549" mass="60352" checksum="2BB020B62635B973" modified="2021-09-29" version="1">MLLLKGVAVFIMLRILSDIIGLHTLSWLMNQVIMYGVIAAVVIFQPEVRRGLEHLGRSSFFRTTKSEQQEDEKMILAFDKAIQYMSKRKIGALITVERNTGLDEYIETGIDLDADISGELLINIFIPNTPLHDGAVIVKQGKIAVASAYLPLSESNLIPKEFGTRHRAAVGISEVSDAVTIIVSEETGDVSLTLNNDLIPRLTQEEYLKILRAELVPEEGSKDKKNLLQHFIEVDYDQDKYFVSGYEETVNVHLSSANRIQLNLESNEDTRNFKVVADLTKTSLGTSEVQLRVKGLSTAVTAEIEPKTITVTIENKVTKKFDVQAQLPDSIEAEGYKVEQTEISPKSVEITTGEETAKEITRVVAPLSDVKPTVDTIKQTVNVQALDSKGQILSIENPAPQVQVEVGLSLPSKEVGVSVTQTGSPPSNVAQYSFSLSDQKVEIRGSKSVLDAIDTIELPVDVSDIKTTKKVKVKVPTNTEYIVSPEEIEVTITPIFIGSDSSYSNTEGQDTATSKQKADAGIVDIGLKVEGEPLFKEAESRRRNSGYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1K1</accession>
    <name>A0A835G1K1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YegS/DAGK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001010">
        <property type="protein sequence ID" value="KAF9404341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1K1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00147">
        <property type="entry name" value="YegS/Rv2252/BmrU family lipid kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YegS/DAGK C-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="231" mass="25754" checksum="809F80ABC85C4998" modified="2021-09-29" version="1">MDIGKAKETYFINIAAGGHLTELTYEVPSELKSIFGYLAYLAKGAEMLPRVKPIRVRMEYDEGVYEGDASMFFLGLTNSVGGFEQIAPDAKLDDGKFSLIIVKTANVFEILHLAALMLNGGKHVEDNRLIYTKTSRLHAETLEPDSRMMINLDGEYGGDAPMEFVNLHQHIEMFANADAIPSNAIMGSILEDYDGESDDEYSETSKEFVREVERLTEEDIDGDGKIADHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2C3</accession>
    <name>A0A835G2C3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000571">
        <property type="protein sequence ID" value="KAF9406606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="141" mass="15024" checksum="B96697036CE04016" modified="2021-09-29" version="1">MHGPGCASHNIKLSAVPAVNCALYLGAACSEVRRSARCRWVCAQCLRERAFVRPAAAERLDPLGGGVRQFITYLGCTPPASDMGCAQKKGCAQKMGCAQKMGCAQKTSPCVPRLLVPCGYVRGEKQSLDRCTLGTDNNLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3L4</accession>
    <name>A0A835G3L4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000635">
        <property type="protein sequence ID" value="KAF9406146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3L4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="396" mass="45317" checksum="C8E8E44B9E65B31F" modified="2021-09-29" version="1">MVSRSESALNSPTEPDVSLAASLTDPLEAHTLEEARRSIRDLRMKYRAQAHQLLTWRRAHRTQEELVTRLQKEKAEQLKSLSSQLLLFESRLVRKQKEISSMLALRETIIMKQQKVIESLQAKLLDNGIESQNIPDFRDMLQDTHLTGDFDSLNDSDSAVIMEDVDFDSSNTPHVPRFRSANPDSVTIVRSISDAIDPNLKYNVVRRSNGFLRRPEILETVYSVEEEADGDSTKGLSAQNSTEKELNDANKTDEEKYKETSLLAQRRDNFRMRSVVLTAEVKSIDNDKELKPKNGKEVWSYSYVPKRMTPANESDDEGTSNAESDEEPEPKSNHVVTYNRVMSNHRNVTKPKDVKYKRINKAKSKSLEELRGRLKNWVDKGNKLTNLPLEHAQSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3U6</accession>
    <name>A0A835G3U6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/potassium-transporting ATPase subunit beta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3U6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9407898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32392" checksum="C82C0C3CF4CF0A6B" modified="2021-09-29" version="1">MGLEKRTIKIILIVAAVVLVIGAIIGLLLGLLLPQRYVELEVWPRSEEYNWEQPLIQVRGNDPGSWHIWYRRLNDFLRVYETSIPEDPPRAPCSVHNRRDQHLRSDACDMAMRLWHPCTADDFYGYAMGKPCIFLRLSHIHYWVPEPYNMTMPMSIPPDMPQHIREAMRHRPANQYGDFVWVSCGGEFSADKENIGPIQYIPAEYPPGFPLSRLHTADRIPYSARNMPDQVPGPLIAVHFENPRRGVVINVECRIWTRDIIYDPKSRYGRARFELFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G445</accession>
    <name>A0A835G445_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000577">
        <property type="protein sequence ID" value="KAF9406543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G445"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032722581" evidence="1">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="79" mass="7324" checksum="A7442E3D690E676C" modified="2021-09-29" version="1">MKSMIIFAVLAFLAVASAKPFFGEIGAELGQAGAGLGAGLGNIGTGLGIGIGAGLEGLGTGLGLGGRGALGGLGLGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4L1</accession>
    <name>A0A835G4L1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transmembrane protein 237</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_013846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000748">
        <property type="protein sequence ID" value="KAF9405400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4L1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9405400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59286" checksum="0584ED4A5BF5EB8C" modified="2021-09-29" version="1">MKPGKSVDVKEEIAEVHTSARSPSPIQKSKRSRSRSGSRKMSNGHAAPDETPVSEEPTGDKSKRDSWIKSEHESLDTELPIHDQIKQGILGFVEKELKNSDKNPSFVFYSHDPNHMDEKFMKTLSRPSSGHKEKRSPSYRKKKRHSSRHRDRDLHDFDIPGSSLSALERVDDYLKEYKRDEVVTLSGELEIEMNDVENNNGISKELRNKPRKTRRKVREERQDSSVNGRDVSPKVFKSTKNKTGTKPVRPTDLTTMLESLESSMPYHDQYIDNPFSSPSPLTSPNDERLDPFGSRRPEKIYLQGGGTFRAVSRDRILESQQSRDGDKYLRLGDLTPLDVALTLQKAWRSSAPACHGVLGGLSLMHLLLISYSDGLDAGHLSFHAVVTMPYVATYYFFCVLCLLSVLDRLDVTSLDLTRGLQPYFQPIVLVMLYTACLLVCTAARMYDELMVYQYAPLVNNITSNITTPTIPTFYHTWTHFSIWRAVLSILGLVYFIISNPQDLVFTNLSKLLQFKHSLQSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G556</accession>
    <name>A0A835G556_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000348">
        <property type="protein sequence ID" value="KAF9408990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G556"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033100553" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="76"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="577" mass="65196" checksum="D568B73603DEBE27" modified="2021-09-29" version="1">MQWITCVLLLCVTAALADDEWREVETAQGVVRGRKHPTEDIYTFYNIPYATAPVGVDKFKAAKMSDKALHFVSSFFQAPVDPPKFSQPYDAIDKQVVCPQAKLPISNLQLRTLVQQENCLIANVFVPNTNKKNLSVAVYVHGGGFVMGWGEMFKATQLMKTKDIIVVTFNYRLGVHGFLCLGTEDAPGNAGMKDQVALLRWVQKNIASFGGNPDNVTILGYSAGSASVDLLMLSKSAEGLFHRVVPESGGNLAAFSIQRDPVEIAKTFAKQLNFTNVDDINALGQFYKTAPLELLTSDPFFYRTDSTFMFSPCVERNMGEETFLTESPLTILKNGNYKKLPVLYGFAEMEGLFRIDFFSFWKERMNENFSDFLPADLKFKSEEERQKVASNVKRFYFGDKPISEDNILEYVNFFTDVIFAYPMLWATKLHVEAGNNQVYLYEYSFVDEDVPIVPHTNIRGANHCAQSFAVLDGKNLTHLSHTDESLATPEYQEMKKTMREIWYNFIKTGKPVPDGSSLPAWPAAGADRSPHMSLGQKIELRGVLLEERTRFWDDIYQRYYREPVPPPAPPSKSRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G559</accession>
    <name>A0A835G559_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_012448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000456">
        <property type="protein sequence ID" value="KAF9407579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G559"/>
    <dbReference type="SMR" id="A0A835G559"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF74">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032711869" description="Peptidoglycan-recognition protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="11">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="57"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9407579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="191" mass="21592" checksum="E6773CB33C921224" modified="2021-09-29" version="1">MELFFKVFVLFATLVAVKGDCDVVSKKQWDGLNPVHVEYLARPVDLVIIQHTVTRTCNTDAACAEIVRNIQENHMDNLNYWDIGSSFVIGGNGKVYEGAGWLHVGAHTYGYNRRSYGITFIGNYNNDTPTQASLDALKALLRCGVERGHLTANYHIVGHRQLIATQSPGRRLYNEIRRWPNWLEDVSSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6D2</accession>
    <name>A0A835G6D2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000562">
        <property type="protein sequence ID" value="KAF9406668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6D2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="898"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="347"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="6">
        <location>
            <begin position="421"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1262" mass="135528" checksum="1D0900944C6ADE34" modified="2021-09-29" version="1">MILTVAVLQVQSPVLVAELNLDRIEGTQLRALGLLAVYGFNVTYEVRAAAQAPGPTSCSAIECRLLGHCYASHDYQDFCCSCFDGYSGADCGVGPLCPTTSNMCKNGGTCRQMGPAAVSCICAPGYTGDLCEAQVAPPECGIEECAEVCKDGTACDCNPKDTDALSARFETRLQVVGLPNENISDEIAKQLTQFLKASNITLEDHVQVLNTSLTTTEGIRDAWVRVWSSKREAPALRAALARLASARTRLLPTSTHFDMHPALSLHKPNQMVTNVNQRPAPSMGGVRIHTNLDIWTRTVSEDALGRRMSVLGVTEAERLDSGKWSCAADDAGRRRCRALRLTVLRPPEIRLVPSTLTVNRGDNVTITCLAGAGRVHGALGFSWARERTLLPMAPGREVWEDLFPAGSVLKLYNVQKSSEFRCQVSSVAGTNAKAVTMWALGSGDAACESDASHGLRWPKTAPGAHATASCPPGHSGETTRFCEPKTGDHGVKWRLPDFSGCVADSLRDIYEQFTLISMGYSWGSVSHVSRQYGAVLRSLPTHPGEGEPPSHTQYTCSTTSCLLPPSRPIGTTKIFDLQNAVVDTAGLRSSFNKRYHEFTVMSKPVLEDNAAHFDLQPALAEREEWAVTSAGVELVTKTENASVVTALYHDLGARLPSLKRFVEYKSGRATQYTIASQQIQLSVSGAGVDNTLLHTVTLLFTHSKNYSAIGPQLACGSRSRSSPRVWSTHTCELRVQEQTYIACRCRGLATIALFTVDSLGLTDAESDSRAIVKITVSLGSAMCLVAALLQLLSLVVGSKTRLPVLLRAATAATHSAAMLTLLECDTKQTSACVGPLGWAVAACWCAGCAALCAQPLLLHTELAATATRAPSVGLLEGVSTLCWLTARLWGGAPLQLGAAANAVCGAGAALLAALTLCLALCAARTLRTVTQKLPPDRREYVRERARVVRHTLVLLFTTTATQIAGVAYAQPGERTILKVVALSVAALANGLAMLICYVICDEECLRAARRLLTLSSNNEWHDSPEGDTSLSLYIRQGREMECRGAVGSLECSSSHVSPANTYWRATPLQSPLHRRGSSGACVADIVRCVEYKQALLPPRNVHTRTLCDLIPIGGAEPRVSRVCVELGVLPEASQTTVTDASTFQPPSDTSDISKANCTLCAKSTPDVSATSTAPRPIKSCLKKRSPQLSWSTSLPSINHESDESNSHLQLVDTQSQTPSTHTTFTQTDKVLHKISHDLDFLLNRTPSRVADNCPQQIEEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6E3</accession>
    <name>A0A835G6E3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_010904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000295">
        <property type="protein sequence ID" value="KAF9409826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6E3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="363" mass="41884" checksum="7BFBD148BA3D15EE" modified="2021-09-29" version="1" fragment="single">SELAAMRELESTLTQKDVLTAKLEESKMKVIDLEIELNESSLILSEVLKMPDGPDMNNIKRSKSFFELQKSGKVVGRLDKGRLSRSDNELDMMHYRDRKREAPNISKLTRKVSDLTKEMAIKNSKLIEQQRCISILEEALRENNNIAEFEQLLAVVRSKDERINELEQIVNKKSVSNPSDCKDKRILELEDALKESFLIAAEREKIFYEEEQRRIETLRRMGKMEQRIRSLQNASAMNCETCSSVLKRLKQLEDSLQHCKTNRDQVLRQLSHVVQDVLEGLISEKDSLIAELEVKGVLDESETNRCDTLKTERDRLLNRLKSENERILELEQWTEPVAQAAPEGSLPVDLTLTDELLRACDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6Q1</accession>
    <name>A0A835G6Q1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA topoisomerase</fullName>
            <ecNumber evidence="3 8">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_012634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 8"/>
    <dbReference type="EMBL" id="JACKWZ010000488">
        <property type="protein sequence ID" value="KAF9407277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G6Q1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="11">
        <location>
            <begin position="170"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9407277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="829" mass="93430" checksum="F69965DC630F8343" modified="2021-09-29" version="1">MKTALMVAEKPSLAQNVANILSNGKCSTTKASNNACNIHEWHGTFKNEQVRFKMTSVCGHVMSLDFTGKYNNWDKVDPVELFSCPTEKKEAMPRLRIPALLAQESKSCDYLILWLDCDKEGENICFEVMSCVQAYMKGDVCSPLVTYRAKFSAITDKDIKAAMLNLGRPNENESRSVDARQELDLRIGCAFTRFQTKYFQGRYGDLDASLISYGPCQTPTLGFCVQRHDEIQTFKPETYWVLRVTASTSEGRELPLEWKRVRSFEKDIANMFLAGIKEIKEAVVVNIQAKEKVKPRPVALNTVELMRVASAGLGMGPHHAMQIAERLYTQGYISYPRTETTSYPENYDLMGTLRQQQNSNKWGAEVRAIIANGINRPKKGHDAGDHPPITPMRPAVESDLEGDAWRIYDYVTRHFIATLSRDCKYLSTVITFQIGSETFKYTGNTLVDAGYTEIMHWQAFGKDEFVPLLNVDDVLRAHDHRLVECQTLPPDYLTESEVITLMEKHGIGTDASIPVHINNICQRNYVTVGSGRKLIPTNLGIVLIDPELVLPTMRSALEEQLNLIAVGRADFHAVLNHTTEIFRRKFQYFVRSIEAMDQLFEVNFSSLKTSGKALSRCGKCRRYMRYIQAKPARLHCSHCDDTYGLPQNGTVRIYRELKCPLDDFELLSWSTGNKGKSFPLCPYCYNHPPFRDMKKGFGCNSCTHPTCPYGVNSTGVSGCVECESGVLVLDPSAPKWKLACNRMRAGLRQCGAQQVTVEYRAERTRLPAAITEMTACLYCEPTFSALVEKHRAVASRAPVSRGRGGRARGNKHRNKQPKDKMAQLAAYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7I0</accession>
    <name>A0A835G7I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute carrier family 12 member 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_012200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000421">
        <property type="protein sequence ID" value="KAF9407938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7I0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="2"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="499"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9407938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="893" mass="97257" checksum="906A54D7BDC58D36" modified="2021-09-29" version="1" fragment="single">NAGLLVTLGQFGLAYLIVIFTVTSICAISTNGAVEVMISRTLGPEFGGAVGTLFFFANVVSSALCISACTEALVENFGENGYLVGANTGIPDGWWYRFMYRSGLNAIGLGVSLAGASLFARTSLAIWMSMVICLGSAFLSFFITPMATIPKPDTNHLVNITGFNYTGLSSTTLYDNLYPAYGRDYTTTDGQMVDFASVFGVLFTGVTGVMAGANMSGELKNPSRSIPFGTLAALLFTFISYLALSLLTAATCTRDLLINNYVYLLPINIWPPFIAVETFDTQFLRYRITRYPDLNTANATGMLMATFSAGLSNLIGASRVLEALAKDNIYGFLLKPMVSRSGNPVIAVLASWLLVQIGIMADSLNAIAQVNSVLFMTSYFAINLACLGLDLASAPNFRPTFKQFSWMTSLLGLLGCAGLMFGLRALYSCGAALACGSLVVALHLFSPAAADPTWGSLSQALIFHQVRKYLLLLDPRREHVKFWRPQMLLLIASPRQAAPLIDFVNDQKKGGLFVVGHVRVGELDGSGDPLAAEHKYWLKLIDHLKVKAFVELSLSSSVRSGAAQLARLAGLGAMKPDTVLLGFRDTAPPIDFFRDPLSPYKTDIFDLESGETIFPTRKPTDPRLSASEYVRIVSDVLCVNKNVCLCRHFHKLDMAKVERKCRSLQYIDVWLVELRAASCEEAFTVRGLFALQLAAVVRSARGWQHLRLRLHAVGLPAPLPTTIHGTFPVRAAAGRRRALGARLAASAPAPACQAGRTVTVGERSALESLAAGRPLEERLDKLLKLLRINASIHIVSEWPKLDEYSRYYSEDEDSLYERVPLSYLQIVNNIIKQRSSEATAVTFVQLPAPPKLSNTAADDNICEQYLKVLDEFTKDLPPTILVRGLKSVTSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G883</accession>
    <name>A0A835G883_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_001011</name>
        <name evidence="4" type="ORF">HW555_001452</name>
        <name evidence="3" type="ORF">HW555_010547</name>
        <name evidence="2" type="ORF">HW555_011188</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000319">
        <property type="protein sequence ID" value="KAF9409445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000267">
        <property type="protein sequence ID" value="KAF9410330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G883"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9423148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9423685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="240" mass="26556" checksum="92A83BEF6C42C602" modified="2021-09-29" version="1">MSQLAEVLSAQKSLEECFMKKMNALEAQIQTAGPAKDTVAKVAEEFRAFRDLVIGMLGLLRRQIGECSRQLDDIETRSRRKALIIQGIAEAAGEDCTNVTLGVINTKLGLNYTKSSIKVCHRLGQANTNHHRPILVRFASIDARMSVWRAKTGFRGSKVAVREFLTKTRQSVFGTARQHFGMKSCWTQEGAIFIKAPDGSRHKVTSLDELNPLLAKYPKAQDPSVGRPESAGEKLKGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8A1</accession>
    <name>A0A835G8A1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome p450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_010835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000288">
        <property type="protein sequence ID" value="KAF9409944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8A1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000035">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="979"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9409944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="128550" checksum="E9BD173E568646AC" modified="2021-09-29" version="1">MHVLIPMQFRLPILNAAYTLWLVGKVEGFSHRSGLNWFASGPHEGRLYFVMRAQIVFDLRMFVITLVLILCVLFLFWIWPRQRKDRPPTFPGALPLIGHGHQLFGNRKHLWKYMRQLCFYSLEKGGVLEMWLGPHSVYILTDPDDILTVSNTCLNKSYFYEFTKDYVQNGLITSEASIWKNHRKLLNMAFSQRIIDTFIDEMNTQTRELVTDLYSQVDKGPFDMRRYLIKFTLKTVSRTSLGLDAEDQAVIDETYVHAFESLLQVYLERIQKVYLHLSWIYDRTQLKKKQDHLTNMLINIMDSVIAKRKSERKNKKREFIEYDAVKPGKFSCLLEHLLQLAEDHNMLSDEEIRQHLDSFVMAAYDTTTGTLMHVFLAIGSYPEVQKKILAEVQQIQPNNNENISKYDLAKLQYVEAVIKETLRVFAPLPGIARKIEKDVKLKNYTLRAGSTCVMKFYGVSYHSMWGPDRNEFKPERWLDPAKLPANPNAFCYFGVGKRNCIGKQFAMTLMKIVIAYVVRNYHLESDISKLESEYEVVLKPISGNLLMLVVLLGIVYVSCWWKRYPRSPPIYPGQLPIIGHGHLLLKYRNDLWSFFQNVGEHVLENGGICQLRAGPYLAYVVNDPEAVTIVANSCLDKPFFYEYMANIIGNGLITSDGHIWKKHHKLLYPAFSQQVLNTYLNEMNTQAQRLVSQLATVSPKGPVDIADYLIEYILRLVCRTSLGMEATDQDMIENDYAKAVEEMANIVVRRALNLGLHPSFIFNLTSMSKRQEKLSIYNKEAMDPIIQKRKSDLTATKYTNNDDVSVPGKFKPALDLMLHLSNEQYVFSDEEIRAHLNTFVAASYDTTSVAMQTVLLVLGSFPAIQDRVYNEIQDVFGNNQNLTKHDLTKLVYLEAVIKEVLRTYNVVPLIARNIDNDIVLPKYTLRAGSICIMSLYGLHRHSSWGPDAKEFNPERWLNPASLPSTSNVFAPFGIGKRICIGKQYAMMSLKTSLAHIVRKFQVSGDISTLKHNYEIVLKPEKPLINLRLRTHNYDSNYNKNQWSFGDFTITLYKTDKLQAIVGSTSQGYKSKILISNQYGDPLPVLQLRRIHILYCGYRQKCDIVGRCVLTPSSSSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G997</accession>
    <name>A0A835G997_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000198">
        <property type="protein sequence ID" value="KAF9412167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G997"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136486" checksum="D27D088572B3ADAC" modified="2021-09-29" version="1">MEGIPTEWVRREFGTTPTQQVVNRCRCELADLQATVILPVKPILEQERALPPEPIPPKPPELYRPDEIMFEKPVFPIPTKPIPHSPKISPSSIPNPNPSVMTPKQVDGYPNFGSYLYSIPGYSAFQPINSVQYPPIIPSTMPPPIQNEVSTSDYMPFPNMNKEPHTTPMVDVETTADMEPSKDVPKQQTDFEEQFTPEIITATSNTEVTNPQTTESKMSITSLAQGSGATVTIPSQIPNKEFKKKPERFSLKTSIPISKIDMKCVSNPPDAAFQNSLTKKPFTSSFAKESSRVEIQSNIVIKSATKEPEVKELKPSMPPNSNVSTFINPTEPVNKTDSQFRVPESKVDLPSEVKDTPSLQRPLFNPVNIETSKVNYSKPPEPSYNEQKNQIVFIQNKNNTNPKMLLTIQQQNPQVLLQRANFDSKNLQAPSRLSNQSKKCKEDVVNESSSSKVVALKRMHQENCDENDFENLITENQIYGNKIVVKEKSQGTSQEQDLKTKKVTEKVTTTITETKNVVLQPNFVYLSNVQFPNLMMIKNNSKVTQTSDSNKPKLAPKEIKIAPEISTPTTVAATAVAVPVAIAPAAVTPATICTENITEVKSSKPSAVVNQEVQVLKTSSNVLQTLPNITKPDIVIQANPTVIVSPQIVYQVPITTIVDAEKVNQPFKKRDYQKFIAPKKEAPKKSDQRKTNDKLFIACPYQMDSKLQPKIVITNLRPKITKVEEVSSLDDYEKRKRLRRLKYLSNRDNKEVKTDAKPEPAKKVIEKTEIRNNIITPDKVKSEIYKEFAKSKLAAHDGSSDSDSDDYGEDNLKVYEEIIEEYGIKDDREKRKVEFMSHLRLATLQDYKEKDLELQDKVLRNDSVAAAYAAVGRLDVLRNVPAEEEPKDEEMDEDNPVFDVQPENRTAMQRKKLFLSKLKLTQVTQKYKEGYDKVWQEILKERKRRHSNPDLDDNCKEPRLGFDPNCQLRLLTEIKKCVNDNNNLIKKRLDSTSNGDSNEESIKVLAEKNFSELNRLSKMADTSVKLFKIPNSRKRDLNPGFDSENIKNPNIRIHQPYENYPKIKIPSVAKIISLKTTQECPTTTSTQATSMDEPQNSAAGVTEVVEETAPPGVTRDIGCQVDEPTWAGLEALAKSYREYDAVRRKEIIELHKRNTTLKIEGAHITRSASRDSDTARALLAERQNLSVEENKLRVSLKKIQQAIDVIRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I7</accession>
    <name>A0A835G9I7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Signal recognition particle receptor subunit beta</fullName>
            <ecNumber evidence="5">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_011072</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000307">
        <property type="protein sequence ID" value="KAF9409599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9409599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="523" mass="60084" checksum="00535DC2E788CC83" modified="2021-09-29" version="1">MRAVISKTCLSGPSSQDFETFTAVTHAKMFACGDVEIGHIVVSEAKASIEESGLKNAVELAEKEHSDLIAGKYEGGLKIWECTYDLIQYLEENEEDIKFEEKSILDLGCGAGILGIYAFLKDSKVTFQDYNKEVLEYFTIPNVLLNIEDEENREKEIQKCKFYSGDWDSFNKKLLSSELFDIILTSETIYNECNYDKLISLFVDRLSKDGAAYVAAKTYYFGVGGGVRQFEQKIQQNGKLNCEILSHTRHPLIQWEYSENLRKQLFDWAQDGRYNQFHRLVLSELLTFINIQIALLPIMTEIKLFNDLALLTADNKTDKLFMDVFWWFFSRRRQVRKSVLLMGLSDSGKTLLFVRLAYSQYRQTFTSMKENIEEYLTSNDALKIVDLPGQERLRNKFFDQYKNSAKSIVYVVDSVTIQKEIRDVAENLVRVTKSSQLQSVDPSQGNNSTYLGKIGKDFEFSHLSNRVEIAESSANTGDDDTPADIKSLQDWISKLYIYDNVRKAQNEHSVCAVFIIIMWFIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9P8</accession>
    <name>A0A835G9P8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000252">
        <property type="protein sequence ID" value="KAF9410676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9P8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="3">
        <location>
            <begin position="115"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="927" mass="100280" checksum="FA66174B54B4A168" modified="2021-09-29" version="1" fragment="single">MDGLIHAALEAEVILNRAKHVNSNLSQYNSGVPDHKMTWTHDKMHLAESVDESRMKFQRNSSGSASKATEKFDLFKKLHELYNELSRDETLQVNYQGLKTTSYLLEKLLAIYNLNTLIINLYPGNKGYSLSLKVNGNSQQLHPPDGHSSSNQEETLIETPRWPYEEEELLSYIDNEELPVVLLDLLETEHSCLFYSGCIIAQIRDYRQAYPSFLCDTHHVLLRPTNQSIITDAMCIGGRCGWAGEERGALEAVEAALVHAAAPPLCLDPRPAVGLLAARLHAAPRLFNTPRIRRQAKRFSQVAVNRKRKLDQFTHYHGLEILDLIHRQRAKNSRQSVPLTRLTSKYPKKPPEVFKPIEPPKMDPLSLAVPSEPGGPLRLARAYERPRPTPDCYPQLVEEYILETEKTSPHASAGFFHIKLSILQRAADQEFLGELYVDRDHVEGETNGAACRFSLGSRLQANKYIQQFTEIFTEEGRKSVRIRHVVPGQMPRVSFTGGMRELNQQLLLQQRSAASGATTVQTNATTVPVVTSTIQSTTNTHTNVRQLPILQAQLQQVGNVAAVGNVVSNVGNVVGNVSNVGNVVGNVGTVVGNVVGNVTATNDTALKQQPSPTTPRLSPQVRICGGNVVGSVGNIVGNVGTVVGNVVGNVITTSDTAVKEQPTLATPLLSPQASTNQLLAQQLTNPPQPINPQKMQSAIIHIQHPLMSTAGTSQVQNIQYTNTTTTQQKATITKPRTTNPAISALVTSLMNSAQQFQQAAASQNAAKAAVSTASSNATILNLLNSAPAAMTHATASTADNNTMDAHKLLGRGVGVQVMSGYSRENEATNVSSSESALLERLMGPDTSAAPTTQQQPVCHLQGLSLASLQGLQGIQGLQNVQVQIPGLSAPISLSLNVSGAPSGLLVSVPPTTSVVLTNQPSVLSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA69</accession>
    <name>A0A835GA69_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000235">
        <property type="protein sequence ID" value="KAF9411089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA69"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11400">
        <property type="entry name" value="bHLHzip_Myc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050433">
        <property type="entry name" value="Myc_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002418">
        <property type="entry name" value="Tscrpt_reg_Myc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45851">
        <property type="entry name" value="MYC PROTO-ONCOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00044">
        <property type="entry name" value="LEUZIPPRMYC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032577329" description="BHLH domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9411089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="45785" checksum="2DB69765ECAD82FE" modified="2021-09-29" version="1">MAGTACVVLIARIFPVIRGSCDIDEFDLALKLVKLKMSPPFDSFVQFDIWEALDEDSVRLTQTSEFWNQVQYEADGLDILPPANFSDPLQESDEDWRVMETQEEEEPHKENIVHHDCMWAGSCADLVHPGNTFVPSDPTTTPTTPGQSLLRRDMSPSRPETPPSIDGDEPPQFRHSVDVAGTALRLLRDSAVVAADHSYTLARRHLDYLGVQTPSDSCESEEEIDVVSLGTQQPLPPSQTHVRTDTLPRVPSAQERQHIQRTVETAITPRSPRPAARKRLVPPPSIAAATSRRRARGPGRRGRRSNTDTDSEAESPEIERRSIHNDMERLRRIGLKNLFDELKKQIPATKDKERAPKVVILREAAALCKKLSHEDIEREKLKKKQLQLVTKLKKLRAALSSRYTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAI4</accession>
    <name>A0A835GAI4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000228">
        <property type="protein sequence ID" value="KAF9411355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAI4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="272" mass="31279" checksum="CEDC5853B9521D35" modified="2021-09-29" version="1">MPNSHRRRGRSVSRESRHHRRDVRSRSRESRSRGRISRSRGRESHNSRLDLQGNRIPRQPDIASNSLLTQQMQQILDRLTSLEEDRRVSRAASLRQPSNQQQQLVEETATTARDGAGFRDSAAPSSPGRSVSAAADRDATVTDRLIDAIRSINTTVRSNQAYFISNFDPSVNDIDTWCEEVDRAKVSNNWTDNECLSRIGNCLKGDSKTWLNEWVTSDRTWSNFIREFKPLCPRKPDVANILYEVMSTNSDRYPTYADYARRSLLRLRIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAN5</accession>
    <name>A0A835GAN5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_006330</name>
        <name evidence="4" type="ORF">HF086_017239</name>
        <name evidence="2" type="ORF">HW555_010637</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000273">
        <property type="protein sequence ID" value="KAF9410200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000258">
        <property type="protein sequence ID" value="KAH9641050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000169">
        <property type="protein sequence ID" value="KAH9642874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAN5"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003205">
        <property type="entry name" value="Cyt_c_oxidase_su8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02285">
        <property type="entry name" value="COX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9641050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9642874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="69" mass="7767" checksum="DD9A5AEAEF290F14" modified="2021-09-29" version="1">MFAVRNLFKANTQILKNVAQHRNMSVIATPARNKITKGEMGVLIVAMIAGWSAVPIWVLVNIKNYRTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAR3</accession>
    <name>A0A835GAR3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000252">
        <property type="protein sequence ID" value="KAF9410680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAR3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9410680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="303" mass="35368" checksum="75F3EFB255EC824F" modified="2021-09-29" version="1">MAGVVVPITIEEEYKKNPDISPEDIKKLRDWLKTQPHLPGQYLTDVDLLIVYHCCQKSMEVSKQVLDLHFTLRTHFVPFFKDRCFDKKAEFAFTTVLCAPLPTPTPEGYRVVYFRLADPDPRNFNLLEAVRTFMMVFDMWQYEEGTWPGFVILIDMEKATLGHVARLDLMVVKKVLYFLQECMFVKLQGVHFMNAPYFMDKLLSLIRPYLRKELMHLVNAHQTGAESIEKLIPQKALPKEAGGEYKDFDTLREELFKRLRANTVFLRDENRRRVNESLRPAGKPSPAEKEFGLQGSFKKLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBI5</accession>
    <name>A0A835GBI5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000220">
        <property type="protein sequence ID" value="KAF9411584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBI5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="145" mass="16602" checksum="542041EC3DC43094" modified="2021-09-29" version="1">MRNHNNEIIIPFQMKSLLLIALLAVTYVYATVDLPEAEFRRPKENASNLRLILGSKSVGDDRLLSKTYHYVERSHRIAHRQEILIRLVDYARITRVEGWPGNPDLGLTVLEGGFGQNFVKLGYVTEENMDFSYTIDVYGVLVCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBT5</accession>
    <name>A0A835GBT5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HW555_010100</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BAW_Kor-Di-RS1</strain>
            <tissue evidence="22">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000239">
        <property type="protein sequence ID" value="KAF9410968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBT5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000076">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000098">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0401">Integrin</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032958002" description="Integrin beta" evidence="18">
        <location>
            <begin position="24"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="19">
        <location>
            <begin position="40"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit tail" evidence="21">
        <location>
            <begin position="681"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="20">
        <location>
            <begin position="792"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="492"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="566"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="568"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="590"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="611"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="629"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="651"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="653"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="674"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="687"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF9410968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="838" mass="92014" checksum="BB779DBACC80A24B" modified="2021-09-29" version="1">MYIHRSTVLRLCVWVSLLALCGAQRAEQLLAQNPCSSKTTCSDCIRTASCAWCFAAEFNGPRCFNPAMERDGTAGCEESYIFNPDNKRSVDPMYNMELSRAKSRMGMSAGSSSYEESYSAQGSSFAASGSAAGAGAEAGGERLVQMKPQKVNLNLRMNQMQKLTFAYSRAQDYPVDLYYLMDLSRSMKNDKEKLSTLGSLLSATMRNMTSMFRIGFGSFVDKLVMPYVSTVPKNLISPCDGCAAPYGYQNQMSLSTDTDFFEKAVANADVSGNLDAPEGGFDAIMQAVVCKQQIGWRDQARRLLVFSTDAGFHYAGDGKLGGIVQPNDGECHMKDNTYTHSTLQDYPSISQINHKVKKHAINVIFAVTAEQISVYEQLSKHIEGSSTGVLSNDSDNIVDLVREQYNKITSTVEMKDSSSDAVQIVYYSSCLSGKELTQTNKCDGLKVGDVVEFTAEITLKECPKDRSKWKQTFEISPVGISDSLTVELEMVCDCPCEQPNHHAYNDSPLVCSGEGVSACGVCVCRPGRFGKNCECSAHGGVSAEQERGCRPTNASAGPLCSNRGTCICGVCECNKMDDPLKVISGPFCECDNFTCDMNKGLLCSGPDHGECVCGKCSCTPEYTGPACQCLKDQTPCRSPENNEICSGNGKCVCGQCVCNVDDDRHYSGKYCEKCPTCPGRCGEFKDCVLCEVHKRGPLYNADTDTCGDCALYPIIEEGKIEANESRNEHLCSFYDDEDCLYVYVYSYNENQQLVIRAQKERECPKKVPILGIVLGVIAAIVLVGLALLMLWKMATTIHDRREFARFEKERMMAKWDTGENPIYKQATSTFKNPTYAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC54</accession>
    <name>A0A835GC54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9411999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC54"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="231"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="420" mass="47853" checksum="841D7C6A16EF816C" modified="2021-09-29" version="1">MRRPLYQITRSSRANRKLKAYSSEDVENAIEKILSQALTIKAAAQKYKVPVTTLKFKLKALRPKRKTPLLKMAVTNEEDLTFKKHLLLIHEMGIPVTFHDIIAVVKAYLTEADKGMTCYRSNNPGIFWCKQFLQRYPEVKEIITSNQQITKGRIVPNTPRTINNFFNRFEGELYSNYVTPDNIYTMDECGFGVDPKKKSLLFRRSSRHPDLDKLCGTSNYSVVFCGNAIGELIDPFFIFKESVPTPSEHPYYSSSTSGWIDTTVFDDWLEKHFVPTIDEKHGNKIVICDNLSAHVSVKALQICAENNIALICPLGNSSHLHPFDFEFYETMQTAWRAVLYSWRGTPTGQLTRWQKKSLASAVNLGIPKDVFCKLVNRAIENNESSSENIVNGFAKCGIYPLSREVVMESLLQEKGVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCP1</accession>
    <name>A0A835GCP1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000200">
        <property type="protein sequence ID" value="KAF9412119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCP1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="362"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9412119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="526" mass="59972" checksum="8BBD7C1B688F6CF4" modified="2021-09-29" version="1">MSLTRLGQKTGGTAEKTAKDCPCYFCNELFELGQLQNHLKICGSILEQCPLRCGAWIQRKHKETHVKDCPKMEKTRTSSSHVSVPAPAPPPPVSNHTWSPRQVPIDDCVSYLEKEKLAVQLVLTEESGHRDVQATEIENIRSKLVLVEERSQHFLSTLVSLRAAVDDEAERSANWAAQFKHDLANVQLALQELQSQQLTTVMRLESAVSSLVHEQHERELLEQALTQHDNKIRAVNKLEEVINYIRQTVEEERERNAENRAALEAELMEARRSSEQLANLSALRMQLQATSDERPGIDRVAVLEVATADARAELSEHSTKVDAVLRDLRALTKSYHKMRNELADFQSKVTFDRNELGSEDGRFIWRIDKFLSRMKDAKENDTVLSSPLFRTSKYGYTLKAEINLNGIGKWKGRHITSTVRLVAGPYDALLEWPCDLNINIILRDQPNNRAQAMDIVKSLQLKRKSSSKRHDYDDGGGDEEKTKSSETLDKSVTQLKRQYIFIPHTSLDKFEYVKNDVMFIEFIVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD14</accession>
    <name>A0A835GD14_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dedicator of cytokinesis protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="4">
        <location>
            <begin position="596"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1684" mass="190670" checksum="63FBA8A8246CCE94" modified="2021-09-29" version="1">MPPVNSKVKKNGAEYENIIAKKCTALDFEQYIQDNKTLLMNDPLRDILLYPTDDVSSVVLPRRWRTVTTAVPDVRTAASCPLLTRQALLSYASSWNLIHYKFSNYSGSYLNLPRPIENKFPEEVYDIDAETESDNEGQAAKLDLGTKEGHLLKGPEIGSDRIFSNLASKSFKKRYCSMVREADGTYILEVYKDEKKTDTKLTIVMDFCSDVVRNPKKGRFCFELRMAGGKGYTFAAENEEDVNDWINAFKAALKKNQDNQETHQSDEALDKDADVSLTAEPPPPTYGTLKGLEHSMNPLLMRYSRETDMSIAAARNECRYNIFSMPYKRAPSPEPQLEPFKEHFGQRILLKCESLKFRLQAPIDGDKELLCQVEPYYTYLALYDARSGKKLSENFHFDLNHDAVKDLVKDNEDTKSLVENFSYDVKLDVNQIPEEWFRSKRQVMLSVNNPHSDLFLVVKIDKILQGHVSQVLEPYLKATKDPRLGLKVHKNVQAYANRVGTYRMPFAWAAKPLYKMYSNDLDLTPEFPAIYRQEPNKMSDDDLLKILSDYRKSEKMSKLTVIPGWLSINIHQSNEQVPNCMSTSYAALKPFPLPPTLPLTLELATLNVEPEQPYAAYIHHLARNIACSIELRDSDTGDNKPMQAVYGRFGMTTQYRCSVLHHNANPTWSDEAKIRLPATITAQHHLLFTFHHIFPVTLLRKMMLMSKHVLGTYAWIPLLKNDKLVDEIVNLPIATHLPSGYLAIQPLGLGKGNTGPEVVWVEGEKQLFRCQLVLDSTVATRDPHLHNLFSQAERLIKSSSPPTSPSPPPWNDVCNALKAAHAIKLSSLIAFLPTIMNQLFELMTVEKSYTQDMGYQIVKLIVHFVHMIHDYGRKDLLDSYLHVLTKITAFIFSSLQYVFNCVEFKLHTMLTAPLHMFYSGFFFDIITKSMAQYLINTGRIKMSRHERFHADLLENIEKLVTTVEPSYILQQPMQTHIFNKNLATFLKSCLSFMDRGFVFRQIKKYLDKFKVCDPKALFDFKFTFLQTICSHEHFVPFNLPLHANKLPKDGDEDPAKLRLTEDFIMRHFLAGTLLKQVEQSLREAPLKRRSALSVLRALLTKHEHDDRYRSRQCRARLAYLYSPWLTIVLDNAHRLITKNLASPVENGHDRVDGDATMNPVLNSTQKEAASANSTPRRNRLTLHFDHTPVRNSAHFKEPPTIPGNHMYGKDHANNMSQSSLESVSTMSGGDSLPRNIGRLDLSEIGDQVNRFGVMSAEEVRDVLLCFLYVLKYLDDERLVDWWRTQSQAQQQSFFNVLEICAEQFQYVGRKKILSEMKATTPDCNGKPKPVKARTLPARMSPPDFSKEPPIVVEKNNTVNRENLVNPSVTTELEAIAEHTVLSASCLATEVGLTIIDRACLFMKNLGAADGVAAKPYLKLLQYPQSETLYKHLFSALRAYINQFSETLFEGGSTVCSGVVAAVVRLCEARAAWLRREAAAALYLLMRANFQHGTGGDLTRVHLQVIMAVSKLLDNSTALNCKRFQESLSVINCFATGDKAMKGTGLSSEVAELMRRVRTVVGARARLAGVGGVGASGAGSVHLAELQHALAASCRATPRLRHAWLSNLAEHNARQGDYDEAMCCQLHIAALMAEYLKLRGTQQWGADEFAEISLNIPRDETGLKIDEVKSNFKYHSLSVDLSRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD62</accession>
    <name>A0A835GD62_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptopodin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000123">
        <property type="protein sequence ID" value="KAF9414827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD62"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF0">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="337" mass="37948" checksum="F60B7D09DCC814CC" modified="2021-09-29" version="1">MMTISESQFSSNKMSSIHKINDRIVHKDSFNDTNSSSSVNSTLITKRGFKPSDMYDPQKKEFLTNLSYKLFPVSWNDAEIPRDNALMEPMDCLTEDMENKPILIGEKEVDLNKIFTPAPDAEEHIIKKDRKSTTHHVVIRLTHITIKNYLISEKTFASSAFYVPGVHPTVKEQMDLARAISKSLSDSSNHMSRGQSMYVNRKKRSVKWVHEGRGRNTSNACSTPTPVANHDTPYRPPSSLRNQKTYPKSALKHSSNLPKMEPFPISPPTITVQNIDVPVPLAPTKLNDVYASPKSPRLPLVSGPNFNVAPRGWGEMKDYYRPVVLDGVGASIQYTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDK5</accession>
    <name>A0A835GDK5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDK5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="2">
        <location>
            <begin position="48"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="438" mass="48334" checksum="56E0A7209614C607" modified="2021-09-29" version="1">MNVHTLLLLLGILLGIWILYGIIKLVMSRVRRTGKLRYGDKELAIQQRLRALDTFRGMAIVFMIFVNDGAGGYWWLEHATWNGLVAGDLVFPAFLWIMGVCIPLSVKSAFAKGVPRWKIVMHIVRRSIIMFILGMSLNTIYGSNMLYELRIFGVLQRLAVSYLIAAGFYALTAPKYYTPPRGACGQALKDVLSCVWCWVLAGILVAAHSVITFVVHDPDCPMGYLGPGGLHDDWVAANCSGGAAGYIDRLLLGRSHVFQRSDAMRVYGGEPTDPEGLLGCLTSAVQALLGIQAGATVLLQRSHKARISRWLAWALVFALAGALLAGFSREHGVIPINKNLWSMSFVLVTSACCLILLCFCYTLTDAWRFWGGGPFRAPGLNAIALYVGHSLCAHLFPFHWKIPEMRTHAISLVEAVWGTALWVIIAHIMAKKKVFVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEF4</accession>
    <name>A0A835GEF4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_007709</name>
        <name evidence="3" type="ORF">HW555_013008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000558">
        <property type="protein sequence ID" value="KAF9406701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEF4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="420"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9414312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="526" mass="60383" checksum="C2DCF256C35EF2AB" modified="2021-09-29" version="1" fragment="single">RQSEIISSITTIKVNFNKDSDSRKNAEYIKKRLGALDALWEEFEQNHSRISDHASEADEYFRLNTYQVGKDLYQSVRILLSSYGKSSKSTQPDGEVDELLAMQRTNFRALSRLIKSIKVENISDKWELEDELNGVQSIWKIIDAQHLKIDHILAGGDISYDEEFTRHELAYKNIKLHRYNNEQALFTHQIEIFLNQPNIQKQSSSEIKRLYDTTTECIHAIHNLGVNTNAWDPLLVHLLCKKLDTDTQTDYREARVEPRKLPKLDELMTFLEGKFTALEQITKYDKEPATSIKRTPNPKVQNNYYKYNNYKGFNHRNYQAQAIHISKCAVCNLNHNRNLFSCKKFINMTPDLQMRIVTQSNICKNCLFSHDGNECTSTKRCKSCQGNHHTILHEALDDEELLLTTLSINVRCSDGTYITLRALLDQGSQISLISENAVQRLGLQRRRYNASVSGIGSGASQSKGLVSIDCQSIYGDYNFTTEALVLSRVASNLPSVQFKKQSWPHLQHLQLADPEYNVSKPIDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEN5</accession>
    <name>A0A835GEN5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein lethal(3)malignant blood neoplasm 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000120">
        <property type="protein sequence ID" value="KAF9414973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEN5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032849359" description="Protein lethal(3)malignant blood neoplasm 1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54880" checksum="A55181E03DA3137E" modified="2021-09-29" version="1">MHQTRRLRLTASIILCFVLQAQGADKYTDENRPYEFGFKIDGQQHRHESKDKDGIIMGEFGFVTADDVYHVTVYATDKEGRFKILSMKNIHLKSSPASGPASPTSARQGHALPLPPASVQTSAVSPVVQTPQPAKAFKPISIEPPGRSCSSCSLPTTTTPAPPPAYNQVSNNNNLNSPSHFGAIGSGPQNQQPFLSSSLGQSNVQSSPPYGSQGGKQNYPSGQPEHPQQGLVAPDAGPTFAAQPVSGGQNYQGSSQGGSGGANSGNKQVGGSPPAAQTYGGTTGQTYSGEQNSLFGAKRRFCKSSTKHGFSRPSTWSYWFKLPICWTKFLCTRRNCRASSAGRTSKQYNPEQQVSSGSNGPQGPASAGGQPGSAKPTLFSAQMQIVDKNTDIHALGPGEQKGLPPGLTQGDMTQLLYTFNYTVGFHAHFEEGYTNGVKKGYYYVTGRNGVRTRIDYVADDTGFHPTVSQEVLDLLSEEVPKPETEKDEKYGLKGYEFKWLYYPVDSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFJ0</accession>
    <name>A0A835GFJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="533"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="817" mass="91643" checksum="BF18728FDB30BBC2" modified="2021-09-29" version="1">MVAADDVLEKAVEAALEAGYRHFDTARAYENEAALGRALNRWIGGDPERRKQLFVVTKLPPGGNRPELVQEYFDASLRDLNLEYVDLYLMHTPFAFQHVPGDLHPKNPDGSMKVDHSTNLLELWKVYHSPITDRQCKVKQVEQTTISKQPYIQIDTDQLQGHENDTNIQACHIVPTENVSTSMTSFVKPRQTVAARINKWYKMTFPKLLCPCCTGGDDTLATYRARNAAGSYESIDLKHSNNALHSLDLDASLMSIIHMHRSFKPKRTPKKVQGHVPKPLNAPRVPNIQHRPNKPRIPNMPQKPDVPRVPNRPRVTKVPRENRPNVPRGNGPNVPRGNRPNVPRGNRPNAPRVYVSNVPRRNVPNLPRGNIPNVPRGNVPTVLPRNESNVSNVPKNIKRRMLETRPHNGTDVIQTNVCYYTKTALNISKFKMMNSNDVIRTGNFIKNQGKCEPSLQCIYVHEDHPLHVPSDHNKLFTPNSTRTFGQCYAAPLKPEPAHNMKQSRGIFASLFVCCLGDKGQGAKHIHRASTTPNGRKQENVHVISSYNCNLYDFGCQYSLKSTHSLEIISHILTRSNSNISSSESENSAKWRSRKNKKPRSLSVMMCTLARKLKEKNSKKKDNVVILRIPKQFSNASNTGKTLLKLKESGRVRHVGVSNLNAEQLARVCSVQRPACLQVEVHALCQQQALLAAANKLGVPLVAYSPLGSKALADALAAKTGREYPDLLQLPVVTRIAQAHGRTPAQILLRYTLQRGLAAIPKSTNPARIKQNITLWDFELSGSELSELAALDRGEEGRICDFTFFPGIEKHPEFPFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGT6</accession>
    <name>A0A835GGT6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000086">
        <property type="protein sequence ID" value="KAF9416651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGT6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000145">
        <property type="entry name" value="Chromaffin granule amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="268"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="447" mass="47974" checksum="193C1C07B328973F" modified="2021-09-29" version="1">MGVASDGFTSQWSAKIAALRESRKLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLSMSLEDITLPPPSPTPYCPCMQPNITSILQNDTQTLNLTAQREERHQELIHETVAVGVMFASKALVQLLANPFVGPLTHKITIFFLFSVFAFGRSYSVLFIARALQGIGSSCSSVSGMGMLAERYPDDKERGNAMGIALGGLALGVLIGPPFGGLMYEFVGKTAPFLMLSALALGDGLLQLMILQPGVVRQESEPPSLKALVSDPYILIAAGAITFANVGIAMLEPSLPIWMADTMEARRWQQGVAFLPASICYLIGTNLFGPLGHKMGRWLAACSGLIIIGLCLILIPMARKLEHLIIPNAGLGFAIGMVDSSMMPELGFLVDIRHAAVYGSVYAIGDTAFCLGYAVGPALSGALMNSIGFEWMLVIIAVLNFSYAPCLLFLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH74</accession>
    <name>A0A835GH74_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH74"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="147" mass="16747" checksum="8CDFCA1111F480FB" modified="2021-09-29" version="1">MGITNSKEYRKKKVDEATSNTNMPNYHRKACACGNEGTCKKKVTPAGVTIHYPQKKRKFSAFGGKRRYKPPKIKKSKFSNHRPINKLKGQPKKFTTWRLDNIAYKTPFNRSFTRPRPNVCSESDISVTVTFDVTSSSDVTVRSEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH85</accession>
    <name>A0A835GH85_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-aminoethanethiol dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH85"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9418042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29331" checksum="84C1C4269D3E6C7C" modified="2021-09-29" version="1">MDKRDEAKSAMELVNIPPIVSIYRHALHTFDDRYKNDLLINLEKLKSMMDFLKADDLGYDNNLKDEALWRQPDKAPCTYIEVFQNNQINMSIFVLKPGFKMPLHDHPHMHGLLKVISGAVKIRSFSEYPLKQDVDPIEFQSVARKEATRLASGYHKRRKLFAEVTCEKVCSETSSTCTLTPTVSNYHELEALDMPAAFFDILSPPYDTLIEGIGPRRCRYYSVTNEISTNVVELQETEVPKCFYCDQAPYLGPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHM6</accession>
    <name>A0A835GHM6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_004782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHM6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000830">
        <property type="entry name" value="Peripherin/rom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00218">
        <property type="entry name" value="PERIPHERNRDS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9418352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="363" mass="40281" checksum="AA90030BCAE68E50" modified="2021-09-29" version="1">MAWGVFTFSRDGRARLAGVLRALLIAQLVVSLCMVIFCYNTSLRVMLLLKHIHKVTVLLLYGLILFQAYGMKLHYTGGLRLIAVLLKCPHWKRATLVSSVWLVSGTLVAANGMLVYAACRGTLKALMKELSSSLRIGISQYLTEPTWKALLDTMQVELSCCGADKPTDWHEIPWINMDFLNEKSELVMKLAGADGKVLPPVSPYSCCTPRVLAPCYHDPLQQSEWREVWSESSPLLSASLHTRGCVEAVRAPLTRALLALQCFNMLVFLFQILIVVLTQLLRTSAREAVLRGDCSGTGRAVLLGSLPLQLQRTTSSREEELLACSSTSAGAAPGTSYCADYTTRRARRRHCRAKTRHSYPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ30</accession>
    <name>A0A835GJ30_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HF086_007887</name>
        <name evidence="11" type="ORF">HW555_004491</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000050">
        <property type="protein sequence ID" value="KAF9418824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000062">
        <property type="protein sequence ID" value="KAH9644799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ30"/>
    <dbReference type="SMR" id="A0A835GJ30"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9418824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9644799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="159" mass="18068" checksum="12B665C315F811C4" modified="2021-09-29" version="1">MSGIASARLAEERKAWRKDHPFGFVARPMKNPDGSLNLMTWECAIPGKKGTPWEGGLYKLRMIFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAITIKQILLGIQDLLNEPNVKDPAQAEAYTIYCQNRLEYDKRVRAQARAMAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJL2</accession>
    <name>A0A835GJL2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_006187</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Myofibril</location>
            <location evidence="11">Sarcomere</location>
            <location evidence="11">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000090">
        <property type="protein sequence ID" value="KAF9416426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJL2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09336">
        <property type="entry name" value="LIM1_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09337">
        <property type="entry name" value="LIM2_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000012">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047075">
        <property type="entry name" value="Paxillin_TGFB1I1_LIM_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="192"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="250"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="328"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9416426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="43883" checksum="59653ABE51B361F7" modified="2021-09-29" version="1">MHRASTSPVPPPSQGGTLPRPGTKQVTVTVQETVVEPAQSQQQPPPTAPAVRHHHHASNATKELDDLMASLSDFKVSGTGAESGTHVYREKRAWQEHYRSNPRQPESASLEHMLGSLRADMSRQGVQTPQKGCCNACDKPIVGQVITALGRTWHPEHFTCAHCNQELGTRNFFERDGRPYCEPDYHNLFSPRCAYCNGPILDKCVTALEKTWHTEHFFCAQCGQQFGEDGFHERDGKPYCRNDYFDMFAPKCGGCNKPIMENYISALNTQWHPDCFVCKDCEKAVKGKSFYAMEGKPECREPFHGGSFFEHEGQPYCETHYHGKRGSLCAGCHKPIAGRCITAMFRKFHPEHFVCAFCLRQLNKGTFKEQNDKPYCHTCFDKLFDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJU2</accession>
    <name>A0A835GJU2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000074">
        <property type="protein sequence ID" value="KAF9417271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="805"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1223"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9417271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1427" mass="161990" checksum="128AD3A9D0748A33" modified="2021-09-29" version="1" fragment="single">AKMSEVQPPLILCMENATGEEVALRIEPDDNFQMFLDKAKALLGFDVDLNSITRNQPVSLSENVYQFLINAEQNLQTDDLTQNFDPMLEPNDGANDLVYILDDGTQIRASQIHFDNDDPLIDLTAEKIPFVKYADDITDDIDLENLHIRETKKINIVDSPVSRWSSKNSSPKCSFANSLPFKLVCNNTSGFEAQFTKYLEANNSKTYATLNPVTIRNKSPKSLIKDNFKNYDESYQRNDNLSYTREDILNMFKDSPMTSLPYDQGYGERRHVRKTDPSRVHKNWTKPISYVDIDGVLIGESESQICFICGKHVDNNVDKLYLFDNEDQRLHRCSPQKKMSTQLKIICECCLNENFKPCRMKSANQFLNPDEYLVIRNNQQYIFQKVKNFSFAHLGKAKEIINKIESKIDKEEFVKVEIGSDGEIITKPIDNDPRSDDVIIVKDEKKDGSSSDVEIIEPEPEIDNIIDNLEEADEDVKEFLGKYQCDNNEITELKFCEQIFPELSGVTEHCETHKHDLEDGEVFPCPLCNYGYANLKWLKAHVIAAHERSDTKKTNETETGKPTSPIALRTRISNKNDGDEIDKENSQEKTDSNAETETTTNAQPPIIKTEVKQECLDSSEDEIWIVQTADADAQDLQKLLCPPKVNDDGQGTISDKSHKCFNCSQVFASADGLSNHRCRRRGRKRKSKDHVNTICIPTEEDFLKRAQGRPRQNDTGIDSDLIVMRPRKRRSRELTSNPQVVTCHNCNESFTSKVRLKFHMQFHDSSHPVRSDGRYLCSECEGATFATETELFDHVHFQHDKQKRWQCPVEGCGKTFFLRATLTKHSRTHTDTRRYVCVTCNKRFLDKQTLDEHGVTHLQEHATKSTECIEAFANELKEEAEEVTVQLSPTSGLVRHTVQIVESPKLSKPIKREVSQEVGAALLSQLPDEARALIRVVEIEKAFRCEYCEDGLNSHRAIHKGVKNPFTCHICKVSFATYSRCTTHKTTHGFYKRSLADAKKTDGIPGTEGASRSATGILGYGDFPVVKHFLCEDCGRSYLHWTYLQVHRRMKHANENFLYKCNQCELTFPNSWSLAYHRKKIHGKTGPDDAGATTKINRDDYRIPCRDCSEVLPNKTALYKHRKKEHSDGAIRPISKTGPYSNEESNPGSGACTHCHATFTHTADLHKHIKEVHSKEGESSTSCPTEPSACPRRPHACPVCGHGFRTLSMRNEHLRVHTGERPFPCDVCGVAFRRSTAMRNHRLIHSGVRAWACGRCPKRFRIRSDLRTHLRLKHPATILVVEMEGLNPTSEEIMKTLALQNVPHDKLIEITKMSFSKGTSSVIPSTARALSALSTVPRTHVACIKPTPARMLDEFQPARRGRGIAKNPRRPKILQRGENAQHDNTAYPIVGGEELGDLNVQLLLRDGVLVDGNQMVQLQLDDPMLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJW0</accession>
    <name>A0A835GJW0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_005517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000073">
        <property type="protein sequence ID" value="KAF9417301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJW0"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9417301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="166" mass="19358" checksum="08D5221019B4E4DB" modified="2021-09-29" version="1">MSLCMGWNNCLQYLKLLQSNPNVNRLVLILHKDCLPHNSKLQLHLNHLVNVTVTYDKTNAHKIWINLKKGNKIIRSEEILSYDSKTSVLSLSPVIKQEQKEEEPEKPLPANLSTFKIEVDQNEKIQKYNLKLPYMSKIHEGESKVYYEPDAVDDWDEEDPDEDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKP3</accession>
    <name>A0A835GKP3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKP3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="444" mass="49848" checksum="D87BD91E9029E98B" modified="2021-09-29" version="1">MAEAAGQCELIKILEETSLRARSHRVVTTDNRVVLSVVAYMFKWRCSHLERHNLLSSTTVFAVTTLCRDSRNGKHDSRKTIKNRGRQLCFPFPLAPARPSRLYSVCFVRVRTCQTPAHGGRITMANNITPEVLIPLVEQRAVLWDKTLDVYKDKGLKLAAWREICCVFEPNFDKLEEKERKDFDNCIDDDALKILDDEGLQQLIPIVGHRMKIKAALKKWKLLNESLMNDSALQEIFDSEDINKNCTIGSQIISYEVQNGALICNSLSQTKNADAGSSIQEEDIISESLKSIRKFTNCSNSSSSDGRAILAEGKRAEGLLKESDRKRLSQIIILHLLEKNPSRAISTCEFQNLAAQIQELFKQESSVVYYSPYEPATGNKGHKKNTSGKLYESYISCRRKLRSRGELPGTSRSSSTSRSTCTDTTETVSVTSSDIDLLGNPTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKR1</accession>
    <name>A0A835GKR1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_005088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKR1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9417943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23088" checksum="028E70F648213F37" modified="2021-09-29" version="1">MSPEEVVWFSAAYIIIRKTIAKRKKKRWWVREYLQQRESSSLLSSLRMRDGSFENFTRMSRTDFEILLNMVGPAIVKQDTKFRKSIDPHVRLAVTSRYLATGDSYGSLSYTFRVSKQVICHTIPKVCQELIKALNSFVKVNAAHNVVEGSWRRELRNNNMRNLNIHGRPPPQPAQVIRNHFAEYFSSAQGSVPWQTNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKT2</accession>
    <name>A0A835GKT2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000045">
        <property type="protein sequence ID" value="KAF9419268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKT2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="525" mass="59292" checksum="5E993CE3848FF83C" modified="2021-09-29" version="1" fragment="single">MLETEEVDDDFFTPVAGASLANIFGLAAKTSEEKSNDSLKYVPPKPQNIPQKQEQTKSTECIFACALIGHEWFNNIYTSRGKLGFAIVKIQKTAIHNIVLYDSNKTTLSCTTVSSNLEITIKNNTYISYYDNLKKYWSVYGTKDEVNKIAEHLSKLDVKIQYSSYTEQGPPEPTKLDIKTDAASEQNEKIDKGSDTDSSINRKTKASILNRMANMGHSVLPTRTLSIERTSDSSDTLETETQPKPVRHKPVKSVLKKSNVDNVTEAPLISETHQRTMVPKSDSMANIPFYPASESQLIPISSTNIITGSNTDLSMFMSEQRISNKYENKIKVYEGLLKSRNLNNTESVTASNLCQNDFQIEILTKKISELERINQDKTNEVSTLQDEIKLLKSHHAEEKVNHENDEAALHQKIHNLESSLQAKDNELTEIHEKIANKTSDTEDNTEEKVKNIMNVTFQTVSSKFDNDEVYSGVLVKQIVGAIIKKITMQTLKDYPEQQELARNPEQQIRRPPRHANETLTNKVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKU6</accession>
    <name>A0A835GKU6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000059">
        <property type="protein sequence ID" value="KAF9418212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKU6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34999:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="387" mass="38435" checksum="2A0C0E45D33348A9" modified="2021-09-29" version="1" fragment="single">EARKCYVCRNCREVKSNQQETCPSKKPSGSSPTPSASSATPTATPIGSTDTPTPTPTSTPTASSDTPTATPTASSNTPTATPTASSDTPTATPTASSDTPTETPTASSNTPTATPTASSDTPTATPTASSNTPTATPTASSDTPTATPTASSDTPTATPTASSDTPTATPTASSNTPTATPTASSNTPTATPTASSDTPTATPTASSNTPTATPTASSNTPTATPTASSGTPTATPTASSDTPTATPTASSDTPTATPTASSGTPTATSTASSDTPTATPTASRRRSLLSIMQARDMSDSETEVQCIVATYIENGVEIISRGCHYPSEDEKSETSLEECRDVAGSSTNITKCSVCKSDLCNASGKPVIGFTLISVCFLSTLYVYLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLM4</accession>
    <name>A0A835GLM4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000053">
        <property type="protein sequence ID" value="KAF9418592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLM4"/>
    <dbReference type="OrthoDB" id="4150at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057896">
        <property type="entry name" value="MTRES1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25818">
        <property type="entry name" value="MTRES1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="2">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="22512" checksum="44CC5F6B10313F22" modified="2021-09-29" version="1">MSYLRRIITPSLISRVLKQEIIQRPIHCCVYRHVNITSKLVDLYSNKTNYNAVRWKSKKRQYDSDDEEIELEDDSSLSKDSKVVKFSTTSMRTDVVLKSALSVSRNKVEQMFYESKIRVNGKKILKKSASVKVGDEVDVIKMVSPKNPDHIYVSRVEILDVTAKEESIQVTARRFKHLLIENYENDPIKTSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLQ4</accession>
    <name>A0A835GLQ4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_004109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLQ4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="502" mass="56323" checksum="AA30D3FC44EC7F71" modified="2021-09-29" version="1">MNKDKRKSNEMVATKNKNKVLSCSTPDRADSPSRDSDSICDSEAASPVPFLCTQDGAEGETDVVWNFYTPKSENAAKSRIKNSTPVSRRSKRSIKPKIIERQPPKRRALKQSLHKKTELFQELIELNQNLVELMSKKTQNKCTEKVNSASEDDCMSESPEFSPKSRVRSNSRCLRRNVLSSNFVKPDPEAALESDDSMNECLIKASQVVEENILNEAPPLKRPCYESKIKKNVVTDLNFKMDNDSMDAILNSIKLESPVVKKIQKCSSPQLNNDSFDSLVGNLNDSALERLTQMPTKLDISHNKSKPNSSKDGNSWMIKELIVHDASPSSKSIFSRHSSMPVSPTVTEMSKPSSSGMVFGRYNSMPFGKEKESSTDQGDSPIRCTPEEIKKKHQLAREKLLAKRLLPFTSSQKGSQSIFNSQQTQQPLPKINEESVTNLSKAGVPKKVQFQPKIASSAILQNKPIPNVQQKPISTSVDLKTIIERKRQEALMKLRRRQIQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLR2</accession>
    <name>A0A835GLR2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLR2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="534" mass="59450" checksum="3F80A1C323FA0A86" modified="2021-09-29" version="1">MATKTIASATVRAVKKRMLPSRAALVLTPSAVNKIKEIMAKDDAKGFIGLKVGVRQRGCNGLSYTLDYAKAKDKLDEEVKQDGVTIIIDRKAQLTLLEVRDRNLSSPCCDNRIEMNNGEIGGPRGRGRGWQQPDNQPRELRRPKIVAEESATEESKVEPSKSKLSADAKEWYPPNYTRHVPTYTPDPASYRPQRFSVQARLRQAQDQNPYNLEEMSYSLDEAENMDLRSAVPQENIANLITVMCEITFDPGKFDNLCGPLVDAFATTLHDVNYTRPLVEAIVNQSIAEPNFRYNGARLCSMYDSVSPPEESTFRACLLERCSTEENKIISGLETSEENMRGFAMFLAEIYTQLEDSQGGRIKTLGESLCKVLLHLLDTDKEVNIKAVCQLLKLSGIALDADCPSGMHAAFERLKRRSSLACVRGVVELRAARWGTAEPEPVPVPPPDVRRRYNYPAMNGKVEGGPSDGGYLADGHTLTAEERAFLQSNLPPGKNVALDEDILEELENDAWDTGMDAEMQAGFLEFLKISNQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMD8</accession>
    <name>A0A835GMD8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMD8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF234">
        <property type="entry name" value="SD01558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="105"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="311" mass="36664" checksum="7CFCFB831AB1AC05" modified="2021-09-29" version="1">MRDTCDMSFIEIAFQAEISRYEDTEFEEYAKRHCNEDPDTRGKVIEELRRLIRERGECNPRRIDDAYLLRFLRCRRSIPALAHKLMVRYEQFRRENAYLYDCDPFNLVLVKDVYAGVLPESPDHGRIILMRFGRWDVDAAAIEEVVRYALVMDEIAIMQPKLQILGVTIVVDLDGLNLRQVSQLTPTVAGQIVSLMGVSFPLPNHNLHIIRYNWILHSIFYLFKQFMPRAVWNRIHFHGNDLNSLHKHIDPMYLPPELGGRCRHVISTEKWLSKINEYKDDFLVQELKELGFNVKCKETKKSQHLNKYIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GML7</accession>
    <name>A0A835GML7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GML7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="320" mass="35870" checksum="E11A1E4CF0823CCB" modified="2021-09-29" version="1">MCYIFSCFAWGLDFLQRLISFFLSCLLAIAICCGLSVAVVSGIAYGYNYSMAEYITFTRSDITVFMRRGAFSNAASLAPIDMGLKEKKPRRSGGNEEDLFNGTASDYEDHKPPAESKPLADTWLKTQDTRKYAEILTRYNPNKRAEVQSGPAREVVPIQSVQQNQQPVIREPPIQEPSPQEQSYRDQIIPVQGQPGAIHYRPSPDTPVISIMPNPMIPTVSWRSGSSEIMMRNFQPVQDHTSGSKHTEMPENLFPIPDKSLDSVSIIGLKDQAKESSNANQRDDFHKSYVPMRVWGTTARAVIADEPEDVDEDNVVYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMV1</accession>
    <name>A0A835GMV1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-cysteine N-palmitoyltransferase Rasp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_002629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMV1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032673175" description="Protein-cysteine N-palmitoyltransferase Rasp" evidence="7">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9421414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="65368" checksum="013D1992961A0B60" modified="2021-09-29" version="1" fragment="single">MFLWILACFYSLYKLLRAQTEILESNPDLHYELRDLIPGWGFLSRFKDEADVEWSTWKYHVQNSWLYMLFQFVISETIRRFNVHLLKYWYILSSIIFITSFMGFKQLVVIFAQPVIFSAIVFSGGGKISIWLTSIFLLALYNSMKYKYFFWYFLDTDHLKDEEVFVILYGIAWVELRCISFCLDYVDRKEKLANQAQEKEKLKEASVFEELINMFSYILYLPLLFVGPLILYEEFEKSFCVTNEKLTMRLKCFILEMLRFQIYTIILELAFHFVYFYAMQSQIEAILKMPSLALCGGGLWMGLEFHMKYVISYGTAAAYSRLDNIDPPPTPRCIVRIHVYSQMWRYFDVGLYRFLLKYIYKPVFTTLSNYFTMPKITNKLISSFITFVFIFMWHGTMWNILVWSVLNYIEYAGKAASKTARYTLFKEKYLKTDAMEVRFTAFLCAPLLGMSAISNFYLFAGSEVGNLYLELLKWPSLYNAVLVYSSLYCCCHVAIALSDVSSRTDVKKTEMKTIDPKVEINVAASGGVGGGQHGGAGSEAADDASLGNAYTSLLHRFQQTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN63</accession>
    <name>A0A835GN63_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_000937</name>
        <name evidence="2" type="ORF">HW555_004037</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000386">
        <property type="protein sequence ID" value="KAH9638536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN63"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9638536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29466" checksum="EE1A473432BAD8D2" modified="2021-09-29" version="1">MADSGVDTSNESSDNPIFDHSQCILEFSPPAIPINQAGQPMPIDFLTEPHDHVGKIKCSTKARQYRLKYRYSGAKCSSKNHKLRFAASTNNTELVEKLLLSGADPNSSDEHKRSPLHLAACRGYVDVIKILLRHGANPNIKDTLGNTPLHLAACTNHIPVVIELLDAGTDVSSHDKNGHNPIQLAQSKLKLIQMRPSGAGHFEETRHLIGEICLVVEMMLKYMKMQKADAGDLESVCQRLERVSTREQVDSEVQNLLDSLDSLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNV1</accession>
    <name>A0A835GNV1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000027">
        <property type="protein sequence ID" value="KAF9420990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNV1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9420990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="102" mass="11614" checksum="1D2F46E350935677" modified="2021-09-29" version="1">MQSSACIDFTPARRLCGPRPPVHRRMGCAMGLHESSDCTLRLFFKLFNFLYGHSSNVRYFKIACKSVAIRLNCANVDDYSYASTGKINKIVQVEDDVFREMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP46</accession>
    <name>A0A835GP46_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000032">
        <property type="protein sequence ID" value="KAF9420426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP46"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="470" mass="51183" checksum="E2E789F1D22ED681" modified="2021-09-29" version="1">MSPGERAALGRREPARPQYATTAPGFPPPYYPPYGVPHPNAWLGAPLISMAGRAPPQSRNTPVSKLAMHAQGAPLIIQNRHDRRKYTTAPEQRSHRPLAQTEHISRDRCDAPEGNRPRNQQQQARSTRGGRNNNTDAVSVASDESSGSTNSETMLPRIIKPRKRRKKDRKPNNIVPHDLSSAGLDLGDVDHCAVSGLNSSHGIYEDTYCREMSLPYRLDVKVLEYPEPVPETYRVSALGEALEATRFGLAEAASPAESAVSSCQCRLCDPVGQIWDADSIADLLDENSCGDFAPTKLEESMKVVGPLGKRGADTTLRRSWSDPSSRVPERREINAGETYSAPNLYSLFPPTRRASSPEPRSPLALDISSEIVTSMNGHRDLEIKLFSTSPPATNSDRRSFFADKSESAVNGCLASKDHKVNSAVNNNNRVETSVKQDGKNSEDVSDTGCSSAFVAGEPSRNICDLALVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP54</accession>
    <name>A0A835GP54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">General vesicular transport factor p115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_002722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP54"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045056">
        <property type="term" value="P:transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000394">
        <property type="entry name" value="general vesicular transport factor p115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="11">
        <location>
            <begin position="353"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="12">
        <location>
            <begin position="670"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="732"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9421250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="91250" checksum="F2B2E467FA7F34D3" modified="2021-09-29" version="1">MDFLKSGLKTVLGAPEPGHQPSGAEIVERLVDRVNNSTLLEDRRDACRALKAMSRTYRVEVGAQGMDTLKQVLELDRADNETINYALDTLNNVMSPTQFEEEETNPRVPLNIGEQFTEMFIKDHHNIQLVLDLLDEYDFRVRLSAVQLLTSLLTNRPKDIQEIILVKPMGVSKMMDLLGDTREVIRNETLLLLIKLTKGNANIQKIVAFENAFDRLFEIVSTEGYSDGGIIVEDCLLLMLNLLKNNSSNINFFKEGSYIQKMLPMFNTPDESEEAGWSPQKVSNVHCMLLIVRTLVSPSNSAQIISSCQKIMKNVGLLDALCNILMSSGVPADILTETINTVGEAVRGDVTNQEFLGNVMAPSNPPRPAIVVLLMSMVNEKQPFSLRCAVLYCFQCYLYHNEMSQAGLVQTLLPSSSDMSSLTSGQLLCGGLFSSDVLSNWFSAVALMHGLIDNPAQKEQLLRVLLATNIGSSPVSLLHQCTLLLQQTTKLKSKVGLLMLLCTWLSYCPAAVAGFLRTNAVSWLVAQTCSAEHDDNEYLLQGLSAFLLAICIHFNDDTVDNYSKESLRQLLTKRIGVEVLTSKLCEVSRHELYNVAAKHPQLRAKLPADVLIDYEFCRLFKLLESVVVQSLSERRPENGAGSPATERASPEDGTLQQYKTLIRQQDACLQELRQEQQALVQENQNLKASLNDSLSAISHLKDENTLLRAQMSAATAIPSQAPPPPTLDDSRVQEYEAKLQGLSAEVTRLSGELKASQEGQKAMAEELEKIKKDQDDLLELLADQDIKLNDYKMRLLSLGHPVEDELAGPAPAPTPGAGPAHAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA7</accession>
    <name>A0A835GPA7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PurM-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_001915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPA7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000006">
        <property type="entry name" value="Selenide water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF0">
        <property type="entry name" value="INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="6">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9422325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="29630" checksum="7D1DA1F11BA880E6" modified="2021-09-29" version="1">MSYQSSVAQDSLAAAQLEMTGNPNALALRRPFDPVAHDLEASFRLTRFADLKGRSCKVPQDVLGKLVESLQQDYSQQEDQFMHVAIPRIGIGLDCSVTPLRHGGLCLVQTTDFFYPLVDDPYMMGKIACANVLSDLYAMGVTECDNMLMLLGVSTKMTEKERDVVIPLIMRGFKDSALEAGTSVTGGQTVINPWCAIGGVATTICQPNEYIVPDNAVMGDVLVLTKPLGTQVAVNAHQWLDQPERWNRIKLVVSEEDVRRRITEQWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPV6</accession>
    <name>A0A835GPV6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_003509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Fibrinolytic activity; shows preferential cleavage of Arg-Gly bonds in all three fibrinogen chains. Contact with the caterpillars causes severe bleeding, due the anticoagulant effect of the protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000035">
        <property type="protein sequence ID" value="KAF9420096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPV6"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1205">Fibrinolytic toxin</keyword>
    <keyword evidence="8" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032722587" description="Peptidase S1 domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="40"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00084094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9420096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="281" mass="30025" checksum="B2FD1F218B3A70E9" modified="2021-09-29" version="1">MDYKAGFLVFITFLIGSLAFPTPEDDMSIFFDHTDASARIVGGNEAAIGSHPHMVGLSTGTLIRSNFCGGSLISQRTVLTAAHCINHVFSFGSLSNSLRATVGTNRWNSGGTSYSIARNVTHPHYVHSIIKNDIGVLITTSNVVLSNLVQVVPITYNFIGPGVQARVAGWGNIRAGGPGSAALLELTTTTIEGNDCVARAAQARIELNMRHAPHVEPHIEVCTYHSPGRGTCNGDSGSALRRVDNGQQFGVVSWGFPCARGAPDMFVRLSAYQSWLRSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQ69</accession>
    <name>A0A835GQ69_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_001458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF2428" evidence="6">
        <location>
            <begin position="745"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9422915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1489" mass="171298" checksum="FB7ECBE8D5B47320" modified="2021-09-29" version="1" fragment="single">QQRKTCWDSRDRYWECLDKENVKDSSEKPKACLDLRKMFEKSCPTQWIKMDSNNIILQEISFPTHELKMKSIQDLLKLSKESSSQNKEFWNQVADILWSHLQTGFKIFDDQLLCATCFYTVLPCTDKQDIYLTKLLLLNEEELVNKNKEDRSSKTYNLVSMMYGIFQSTFLIQKSHSEVTKSVLKPVFDLLLLMGYEYSQYTFITFKTVKLFKKVVGTDFQDCIFSKANQVKLLNFINHNWENPVTGIRDLNRSIFQTLLTTLDDEMYQIVAKEINSFYWNKAKYLMLSEIIENKNGKALPLLKENRWVDGLIYSLHKPGLVSAGADMYYALLKQINFEKDWCTIFLNDVIKILNGSSSKAIENFHNFWCLITMKKFPTVHHILLDKLRNHDNCDQNLCSQLCIMKQANRKGLLEKNWKSKDCDYIEQTILIGLDHCNSYIRTLAFDIVCVSQGKAAPSQLEYDLLLNFIHNNINSDNTVLRLSMLNSLNIFLTQLHSTFLNVMIKDESNESLQNRKSLLEFCTKLQNCVVTSINLNGNYQRKITCVKLCSTIISCFSEIPNKKKGQIRNMNMTLIEYVKENGCWVLSTDDFVVKLISLLSDPTNDIRENVAKLLLNHYSVELENPNINQHLVNGALNSMRSKFFYEISCGQSMFKLITNLVIKHKHSIGQYKNVEDIFYFAYNQLVSEYKAKTNIMKSIESGKQLHSFMNILLVVLETCIANSYKIDIKGVMPEFAEVLENISNQFAWEEDSSTSSDFSKMSDMVENIIDKSGLIISDEIDQTKISGFHQIVLNSLWLNVKASCDLSSVLVQLNVDDATMAEKCLNIITHVLETSRHKGAIEAAGASLGKGIQFLTSLPEENKASEVPNILLRCKLNDLISETNKMASITRRGAGLSIMVHRIVSSDMKKGKPLFHYFINTLLDICNSTKDTPKRNDENQIDLPKAIYIHFLTRIVTDSGLATDMMFYFAKLAELAFGNLTSAHWQIRNAALQLYGALIPKQIGEKKASGSDEQTTATVACDELRTHSPKLWKYIMQQLKLSNQPDVVQSHSNLVPILNLLANSAKRYNFSFDIQLQKTADEDLLKCLFILLSSPIHTVRRLTAKCIFNIYDAIQIFHILLTHVFLSENDLHGSLILLSICQKYYLLNEAYPEYFEQLKEKFERIISSGNHSFLSRTLFEDVFINSYKLEDIETTIMQVNSSVHLSGVDLWAEARLKKYIKISEWNNIPNLLQKALKLSNHEKYCEFILLKIKEQKCALTENLLEIVDILLSFEKKYYSSITWKIIYEISLQTDVSNHLDVVELIKVLVESQSVYIIRYMIPLLARNILGLEKDGQMSLMEIIQKLSDFEISDVDMRYVAATANNELANVFDNLSDSVKVITIRCAIMLLQDEDEDVRNKSVIYYSKLSKQEGDVQPYICLNNILNRQFLYLKLNGSQHLINELVNDLSVLLQSNHNVDEYNPFANDSKNIYLEPDVLKQLIENLNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQB9</accession>
    <name>A0A835GQB9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQB9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="211" mass="25152" checksum="1D6CEF4AC937296A" modified="2021-09-29" version="1">MYRYPRYFWPSCAITMDMFTTLLNSIPKNRLDYVEDLEIPDFTLTPYVCPDPYDYLPSRSDSILDSVRAFDRRTLSTASSIPLSRAMTDSEIDYGFYKRYRDCHYADTWEHLRRAVDAFPPYYLSSLNSFISLDTDEDLLLNNELAYAAELAEARRLYNEEWRRRMRTQFDDYYPYLPGDPGLFELQEAIRRLDMKVLDLKVCVEFLKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQY2</accession>
    <name>A0A835GQY2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HF086_008374</name>
        <name evidence="4" type="ORF">HW555_002019</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000018">
        <property type="protein sequence ID" value="KAF9422210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000871">
        <property type="protein sequence ID" value="KAH9629292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQY2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9422210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9629292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="126" mass="14639" checksum="A4E3FE2F30FADE6D" modified="2021-09-29" version="1">MAQILELHGYNQFKDYVSNLDSKSRPVVFYFSGEKLPNGYSWCSDCVEAEPVVKAYLNDLKKEIVFVYVDVGDRETWKDKACPFRTDSRTKLMVIPTIIVWNGVRRLEGSQCGKRELLDMLFEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRU5</accession>
    <name>A0A835GRU5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanylate cyclase soluble subunit beta-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Guanylate cyclase soluble subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Soluble guanylate cyclase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_002153</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRU5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000005">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000001">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF2">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="443"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9422132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="631" mass="71591" checksum="0054DCB568A66A7C" modified="2021-09-29" version="1">MSYFFKVYVITRQSLGQWRAYVSCRQTVGAGSNYGFVNYALELLVTKTFNEETWETIKKKADVAMEGSFLVRQIYEDEITYHLITAAVEVLQIPADAILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDGLHDHLGTLYPGMRSPSFRCTERPEDGALVLHYYSDRPGLEHIVIGIVKTVASKLHDTEVKVEILKTKEECDHVQFLITETSTSGRVCAPEMAEIETLSLEPKVSPATFCRVFPFHLMFDRELNIVQAGRTVSRLMPRVTRPGCKITDVLDTVRPHLEMTFANVLAHINTVYVLKTKPEEMVSAPDEDIASLRLKGQMLYIPETDVVVFQCYPSVTNLDDLTRRGLCISDIPLHDATRDLVLMSEQFEADYKLTQNLEVLTDKLQQTFRELDSEKQKTDRLLYSVLPISVATELRHQRPVPARRYDTVTLLFSGIVGFANYCARHTDHKGAMKIVRMLNDLYTAFDVLTDPKRNPNVYKVETVGDKYMAVSGLPEYEVGHAKHISLLALEMMDLSQTVTVDGEPVGITIGIHTGEVVTGVIGHRMPRYCLFGNTVNLTSRCETTGVPGTINVSEDTYGYLMREDNYDERFELTYRGHVSMKGKAEPMQTWFLTRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRY3</accession>
    <name>A0A835GRY3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CIP2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000009">
        <property type="protein sequence ID" value="KAF9423388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRY3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042510">
        <property type="entry name" value="CIP2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23161:SF2">
        <property type="entry name" value="PROTEIN CIP2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9423388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="91394" checksum="BE3A01D358A5E265" modified="2021-09-29" version="1">MDMEVDGIETLSNPSEGGKFSNLKAFVTAAREFEATHSESAVNLMTRYLGLIASSCDLSIFSPGRSEVCAFFSSLWRVMCDGRGPHWAGVAVLSRAAIEPSARHALTHTYKFMPILARLLSDSISNDKKIKLLSVMQEISYGIKISWQESYLSSLMKQLTEWITQPMPEPQLRTIGHKSLTVLVNVCYGNLPAIYALMRTVDTKDFVVHLISLKDGGYGGVEVCRLLLCLSGATRGAASTRQPDVHSYLCCTMRTFNKAVSEGDATQLLHAYTFINDLCSDTNLRSYVLTYPHFVNALEEALKDVQNLCQAAPDDMGEPENTVNCLRNVMKFLTVLVSLDEGRLPQELISVINDGLPGLLVPPSLEPGKAGVQWLQVVGALCESVETQERVLQEVTPDAFEDTLYSVLQYTSQNGVVGAEASQQAVVVGCRTALCLAPLDPHWEAALARMLAHHQVRKLLCVGLTSTNGPRRRQILQLVKHHYFPSDQMNQVFGESLHGVSESTSDLATNGSGTGCSEGAWCGRLAPAQEHVVDELVAKLNDKLRDGKISDIATSSVMELYGYKMTCLEQRLHSHSVALQGASEHMASLQHSLAMLQATNSSQQDVLYTTQMQNERHKKTIEDLHKQLEDAETTLRGFRAKLAAEKLDKENQKENLHKEFRAQMATLEAEMKLREREFEDRLKTSEAEYRALQKKLEQQTNKNSELAGVLIKFEERVKQRDKKLEDAASNEAALRKEIEHRDMVYCKTTREDCVRKGEQTVPADDSAGGDEASPGDGRQADEQECVYQYGELTLVIQHVKDSHGVDRMPFFKVAVNRSKVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS47</accession>
    <name>A0A835GS47_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000011">
        <property type="protein sequence ID" value="KAF9423094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS47"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF105">
        <property type="entry name" value="FI02074P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="567" mass="63673" checksum="494777FBA847F4D2" modified="2021-09-29" version="1">MSDINFSFFPGERKILHNVSGEFRSGELTCILGPSGAGKSTLLNILAGYNSNGVKGRITVNGHTREMKLFKKLSTYIMQEDLLQPRLTVQESMVTAANLKLGKELGKAEKELIVEEILQTLGLWNHRNTMTEKLSGGQMKRLSVALELVNNPPIIFLDEPTTGLDIVSIRQLVVLLRLLSRQGRTIVCTVHQPSASLFALFDRIYVLARGMCCYQGAPQLIVPFLAEAGHICPKTHNPADFVLETLATDIETSAPLSELCQNGKLCRRLERMMPGSRKPVLHSEESIQRIFTEHVAKDQLSKVEFPTSFWTQFLILSKRMFIQNSRNSTSMWIQFIHHVLSAILLGSIFFDVVPFQVRLLRREYFNRWYSLKAYYAALTIASIPNMVILGIIFLVIAYLMSGQLLEWDRFILFSIAGLLIATCSEGLGLAVGSAFNVTNGSIVAPATAAPLLALSCYGMGFGPYIEATMKALMSISFLRYGVTGFSIALYQNRQKMECNQEFCLYSEPKLLIRDLGMEGDTYMIQVAGLIGFTVLHRSLAYLALRYRLTNEFSNKFMCYVSKFLKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GS62</accession>
    <name>A0A835GS62_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GS62"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9421694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="21502" checksum="0056C9DB8D334CCA" modified="2021-09-29" version="1">MTFQLSLYKMDEPPEELSRTPNKERIPILSLRLVSVILLVAVLTMHVRSVRVFRWEQSVTGGVLVTYCLAMTGLAMCAGQTSMMARHCRHQPAYICSTGSALLLVNASAIWHRWRHSGELTHAVAELLLALGLPLRRHIMIKVFLSAAAAICLMLDLALLPIMSFINKGSEKYVLSCFSGLPFPISQSKPVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT18</accession>
    <name>A0A835GT18_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_000913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT18"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9423855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="12068" checksum="8DD289797A3EBC69" modified="2021-09-29" version="1">MDYNSHKNTNDRILDLVLSNNYLDVAKCSEPLVSEDPHHTWFSPSVAIKVFYSVNSLLTFSANIESFRGLSIDLKHDPGPKYEEVFLAALEVVEIILESRLKAASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT67</accession>
    <name>A0A835GT67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="10">TDO</shortName>
            <ecNumber evidence="10">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophan oxygenase</fullName>
            <shortName evidence="10">TO</shortName>
            <shortName evidence="10">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_000495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Pigment biosynthesis; ommochrome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT67"/>
    <dbReference type="OrthoDB" id="447477at2759"/>
    <dbReference type="UniPathway" id="UPA00271"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:L-tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019442">
        <property type="term" value="P:L-tryptophan catabolic process to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006727">
        <property type="term" value="P:ommochrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3810:FF:000001">
        <property type="entry name" value="Tryptophan 2,3-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138:SF0">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 10" id="KW-0349">Heme</keyword>
    <keyword evidence="5 10" id="KW-0408">Iron</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9424356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="416" mass="47840" checksum="92B8C079BB0B2764" modified="2021-09-29" version="1">MACPMRSMMDESTAQEGNHLGNEAGMLYGEYLMLDKLLSAQRMLSSESSKPVHDEHLFIITHQAYELWFKQIIFEVDSVRALLDVEGLDESHTMEILKRLNRVVLILKLLVDQVMILETMTPLDFMDFRNYLRPASGFQSLQFRLLENKLGLKQALRVKYNQSYQTVFGDDPEAMDALQKSEQEPALLALIERWLERTPGLNTHGFNFWGKFQAAVSKLIKDDIDAASQETNENVRRHRLQDAENRREIYRSIFDPAVHDALRSRGERRLSHKALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLLPRSLIPPLDDGMKKSLTLTWGDNAKENGQNVQNGAHSQNTEKETNGDGGAETSFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTV0</accession>
    <name>A0A835GTV0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_000137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTV0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9424836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="394" mass="44687" checksum="3061150EE6211413" modified="2021-09-29" version="1">MSNYEARRSNNGYFTFTRLTHFTSSRLTIVEGFTIQSVFATLLFAGSFIYVGQLSQLIYLVQVFPDKVETFKTINCISASSVPLSKFFFMWCARSRLKTVFELSRYGLSSIPDGSASKKKMLSALKRARYVSWLVVANEAFTHVTYLLMPFLFTVFGNDRYLPTTPGETYGLSPKYETPFYEITFVLTCVATAFSAINQTGYIVLFVTLICHELGHFYAITEALDEIHTILIKNESSRNNVVEGTGRESVDDLLMFCVKHHQFLMHYHGKIRELYKVIFGAHFLSMTVVLVTTLQTMNAWDVRNTILTGVTGIMPLFLYCFGGEMLISAGVQMSTSVYGCGWELMEAKQARVILLMLCLSQRPLYLTAADIFVMNRETFGDVAQVVYKIYAVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GU15</accession>
    <name>A0A835GU15_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 126</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_000650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Flattop family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000004">
        <property type="protein sequence ID" value="KAF9424257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GU15"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23705">
        <property type="entry name" value="Flattop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032084">
        <property type="entry name" value="DUF4812"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038797">
        <property type="entry name" value="Fltp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34639">
        <property type="entry name" value="PROTEIN FLATTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34639:SF1">
        <property type="entry name" value="PROTEIN FLATTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22611">
        <property type="entry name" value="CFAP126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16071">
        <property type="entry name" value="DUF4812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4812" evidence="4">
        <location>
            <begin position="619"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9424257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="681" mass="77086" checksum="E9B73AB8C467109D" modified="2021-09-29" version="1" fragment="single">NSVFSLFYQQFNKESTPKRLGNWQVPRWAPTRARPLEMRPDPKPICDINGHFLPGAPRGTSRCFGHYTGTWELPRKITRKVAEELAKEPPNGRFPDWLNLRVQRPKVIAQTRLRGGKRGKPQKEPGATKLQDAEQTFEDNNTEQQTNEHDNNTIQKNDEKVNDPLELNIKKEPTDTEGRGPYVPGDLTDPDKRHESHDILVKDAVEQLHGPQEDDVDKFWKKVAENAKKNDQLDEQNNMRDNKTSGTPKLPQVNVAQNFQFARKMHVGNLEHQPLPDTLGYRNLTKIAEHRDSDIIVKPYAIGWKGYGASGPTCCTKMRVHRPKTCDPKKTDGDKGESQRPSTSAPDLGGQYTKPMSLMDLAICWDFRPDDPKREPRPPKHIDGSNGSKAPAVFTMVHTPKEEHEGISIGHTNPIFNQNRVVGDVGHHPVPYFEKDMAKERRRDSCDVQHCPQHASANEKASRSASSSRKSSGSLKKPECDGIHGCGTPSDMSHKSSRSDSRPEKLQPIKDAWNTKSKNNNSAYDVNRNRHSLESYEKTPLAQGKLHHSSPNESQQFSRRSTKDSDLLNPKHKNCVSCNGTKLVQDTKQKEDYKFAFKAGNPNSVQSVTGSTDSKGVKMPKMRHPYSKKSYTIPTLAPPFSIWRDANATGYPEHWRLASVYQHAYKPPEQRRKPLIDSVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GUE7</accession>
    <name>A0A835GUE7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_001311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000010">
        <property type="protein sequence ID" value="KAF9423242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GUE7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="44"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9423242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="327" mass="36782" checksum="8B0BE7E73C3C901B" modified="2021-09-29" version="1">MRLYSFYLFLCICLNGITCINGGFKGWLLNLFLKCPVSRNQSLDVSQISVYFYDFQRDRSKSFPINKAAKGILSFDKLDKHKKFYMFVSGFATYINHTNANLVRKTFENVPNSYLILIDHSAYTNDADGPKKSYERSVQYVYSIGLKLAQMLAELNQGGINAKRFHAIGHSLGSQMLGYVGTKFMNATGNKIARITALDPAGPCFTKSFREEQIRAGVADYVEVYHCDDGGLGTSNVLGDTDFYMNTGSAQPQCSFPSTNKCSHKACVSMWMASVDHRFLARQCDKFKSFKQWKCSNNITTTAGFWNPGTAKGIYYFSTQGYKLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GVF7</accession>
    <name>A0A835GVF7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_000098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GVF7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9424797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="44761" checksum="4592AA5B9FCBCD78" modified="2021-09-29" version="1">MNITRTMVASSLMIKSIGSVVTKTWIQSTIQRFCGTAAASPKKFDLKEEKAEFLNALPGVIDQFAKHVKFQEIPGTEKWVRNVLNGNLIGGKNMRGLTTVMTYKFIEKPENITEETLRLARSVGWCAEILQAYCLVLDDIADGSITRRGMPCWYRREDVGIAHAVNDATLIHFSLLQLLRVNFEKFPYYNDLYHNFNETLFYTCLGQYLDIMTGMKKKNYDLFTMDQYDAIVKHKSAYYTYKLPITAGLMLANQFNEETHKDADEISMQLGRLFQMQDDYIDCFGDENMTGKMGTDIQEGKCSWLAVKALQHCKPNQRAVFSVCYGSHEPAHVERVKQLYVQLKIPQLYKEEENQIYNNIIKRIESVSSNDHQKLFLKVLHDTYGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KXL3</accession>
    <name>A0A835KXL3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000811">
        <property type="protein sequence ID" value="KAF9405097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KXL3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="579" mass="66414" checksum="7640BE4CF1DAAF87" modified="2021-09-29" version="1" fragment="single">TDELPINEEPIYKSENRDPLSNVPQSAPTLNTYKVTTKHRKILQTVTQDVENEFNIINRVKDHSQTSFCLPQTSKEYDNVANFDTPASPVSRLRRITRSQRLSQGTERTNELTCIGSASSSICPDSPQSSISNISNTSQKSLDLFPKHKISSVAKKTSPWKALLRRMKYKANRELKLKDQKIQKLKINAKCRDTCLCVEHENMDLVTLSLKKYCIIKEKSSTEILTSLTCNLRSIDCLTRCCIICKEKHLEYKEFDNSKQIEYFKWTKIKKTYMKNGKEMKTTQTLKQKVEANPKDVINYFENICSSYMHHCANIIAQNSYIKKLKANLNYDECLIHCDFSENYNTKYATEIQSFHFGGSRQQVTLHTVVIYYKEDELLQSQCFCTIRIILEEVAESAILEKDMLIPQDIKEFQGTMKVHQVIWSANTKNVLAMRRLSCDLGNCSQEAVQCPHGNHIGFYQIDSDPNLNTSKKNMSRTSKKTSRPSLVKRSKNCDQEKQIQLPQMLNNRQTITANQSQESLHNSDLPDSFWDEVPSIDYENLITPSISEVVLSSLQNDKTLTKAAAAEDLSDSDDYSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY43</accession>
    <name>A0A835KY43_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_012237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000424">
        <property type="protein sequence ID" value="KAF9407905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY43"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9407905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="98" mass="10999" checksum="B03FB13E3472F940" modified="2021-09-29" version="1">MPTFVVIDRSYLRITSQEFTTLPLDIVVQAVVSLFAVMWGVLNVAGNLREIPAAAELNTVKWETQRNLPSFYIFNHRGKALADNYIPSGGKCELENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KYL0</accession>
    <name>A0A835KYL0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_012931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000545">
        <property type="protein sequence ID" value="KAF9406823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KYL0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF340">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="70"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="665" mass="75262" checksum="72F1BBB19D2F95D6" modified="2021-09-29" version="1">MLNQTMKEEEKKTDPDLESATGTDPVTVIPGDFGSQGRPARFKAKNNPIDAKDYDFSSKRTTLTPPNNFIDSMIHMLMYGLGGGLVVLHAAYMECGIFLAIGINLFLAVLVGYCVCMLIWSAQKLYGRLQMPVLSYPDIIEATILLSPWNKFRKIARGVRYILEGTLMMHLYGSCCVFIIMMARALKELVTGDHNISDAGYPPLKAYIISLVVPCVMISMLIDLKVLAPFALISNIYAFAVILVLIWYTFHSQVGSPLERPPYKSVMGGFQFASLCVFVLEPVSYSLAVENNMKDPKKFHYVILAMPVYTACMITVGFFGYWYYGENCVSPITIHYPYSAFGVLMKIFLCIILYVVYAMCFHVAFDVEWFYLKRNHLISNRWIWERLYRAFHVVVLIIISFLLPNVTRIMGVLGGLFTAPAVIVYPAVIELILDWEYPGLGRCKWRFWKCMAIVIIGLVTVFGGTYSNIVGMVHEVKVENKPNYTHGDKDDNWKYKVLRINTDFNPSLNLYDTNDFDDNPYDTKSKHINNAIPNINANSVLPYNRSYPEPEQMTESLKNVNTNNSNVYVILRSGDETNDIVIFDSNNNSTAVLSIEKSVHITPAIEKNSRTTSLDESTIPLITNNNFVTIKPDIKREFVAEDSSIDKDLSNVTITYAFVVKTDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZ22</accession>
    <name>A0A835KZ22_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_012435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000455">
        <property type="protein sequence ID" value="KAF9407587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZ22"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9407587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="161" mass="17883" checksum="6863D2F4D25A943E" modified="2021-09-29" version="1">MNLEEAFANLEKELKTDVDSLTQKKKWKKRSHYSPPWETVNKVKLDEFLNVVGQIALQLSKTLEDIAKRLMETPPASAKTAKVVDDTKEQEDKLRSLFNDVPDKKNVSLDQFKGILQKFCDEFKKNMEGLATQLATTAGASMVQSLAGTATAGLPGLLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZT8</accession>
    <name>A0A835KZT8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000261">
        <property type="protein sequence ID" value="KAF9410495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZT8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="822" mass="86346" checksum="EBB5E58BB2B0CA14" modified="2021-09-29" version="1">MKRILVDSARLTMFASKFTLFILLLQWVPSLLMPLLQEDASTLDNIPVSTTKNSSETVLNDIKQDTIQDIAVKEGENLIKISFKEMTIDPDVAKIDENVPTKVEKSRVGNAKVTPSDINDRILTEVNAAIEAITEVNNKEDDKNTKSKLKTPNAIIINLLNNADPVNYSATNTNCDTSFYNLEISEPKTVDNDTPVNINDDTEFPKAGLPVFRSLIPLTQLRQQLPISLILPKNYQMIPRENLATDNSPIDGLFGNAFNFIRRLKRDSEQIEKKNCSLINNDENCKPKTMKKIKIDLSSESARKAFEDIFNINKVGHSHEETSSTELSCPLTVFLKVMYEDISKQLTSDGSVIPKNVAAILNSISKGDNDSLRLVNKELSEVPFPTKVKVQLENGDEKNFLKELSDYVDTTLCSVTKIKLKSGAASERNSIASGAEVESVASLWVRYVAELAWRTDRSLCGSGVRYRAPGVVVVIPSVVVSAPGVVVLIPSVVVSVPGVVVVIPSVVVSAPGVVVLIPSVVVSAPGVVVVSANVVVSAPEVVVVIPSVVVSAPGGVVPRVKIDNKMPNISYEFRKKLNTHPCFRIKLKSLAATLGVVAVIPSVVVSPPGVVVVIPSVVVSAPGVVVVIPSVVVSASGVVVVIPSVVVSAPGVVVVIPSVVVSAPGVVVVIPSVVDSAPGVVVVIPSVVVSAPGVVVVIPSVVDSASGVVEVIFAVVVSAPGVVVVIPSVVVSPPRVVVVIPSVVVSAPGVVVVIPSVVVSAPGVVVVIPSVVVAAPGVVVVIPSVVVSAPGVVVVIPSVVDSASGVVVLLSVHPPSAIGTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZX6</accession>
    <name>A0A835KZX6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL35m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L35, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000614">
        <property type="protein sequence ID" value="KAF9406275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZX6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="355" mass="40210" checksum="039C9D743AB664D9" modified="2021-09-29" version="1">MKPVRNIRPFSVSYLNAANVISNSSRHYGIIQNLRTPIHSCIKQNSLLNNKQILDISTNLSVVPVRTVTKFSLQKGKRKTVKAAVRRFFRLHWGGWIRTKVGKHKKMWKKSSPQKRRLRQHVFCNSTQSTMLDKMVTKFWKRPKYYVDDPYAPYHTREEFAITRKKPLHSYFFHGGRYSQMDLPAAFQPPSIWKDAVATPSFKSSGNFLISAAEMSATDVVTKAAASDIIRYAGLTIELGAHLDLTSFVVEMRNLSLHPFKVVHKTPSGVSGNITPVYFNSIQYGVQIRYNTYRTFQPPSIWKEAVATPIFKSSGNFLISASGLSSVVAVTKVTAIAAGFGNRYPRPRYVQDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0A0</accession>
    <name>A0A835L0A0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_011116</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JACKWZ010000310">
        <property type="protein sequence ID" value="KAF9409551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1377"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1429"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1455"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1517"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="147"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1318"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9409551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1552" mass="177181" checksum="222098B12A6280BC" modified="2021-09-29" version="1">METTPLLTRPKKKSLWSRLQFWRFRKKKLSSRAIYLGQLPDEEFPPNYVCNQKYNILTFLPLVLFEQFRFFLNLYFLVMALSQFIPSIRIGYLYTYWGPLCFVLAVTLFREAVDDFRRYRRDREVNRQRYERIVLDNSASDYRPFITEQVASSELRVGDIVMLHKGQRVPADMILLRTNETMGTVFIRTDQLDGEIDWKLRIPLRSTQKLPTDAHLLDINAQIFVEKPEKDIHSFIGTCTRLDEGETDSLHIENTLWSGCVVASGQATGSETRSVMNNATPRSKVGRLDLQVNDLTKLLFVATIVISMLLIILKGFAGPWYGFLFRFVLLFSYIIPISLRVNLDMGKAFYSWTIQRDKKIEGTVMRSTTIPEELGRIQYVLADKTGTLTKNEMVFQKLHLGNALFDKNNFYEVEALLTQYVTNDTPSLPTSPTTSIIGDGLAASPKQVWETVLAIALCHNVTPVYDVPSDSQADEAQSDMGSSVMSESCGGAVPQQQLCDYQASSPDEVALVKWTDMMGVSLYRRDIHNISLKLRAANEIIQYTILQIFPFTSESKMMGIIVQEENTGVITYYVKGADVALSKLLDSQWLSPECKKLAADGLRTLVMAKRTLTKEEYLQFETEYKEARLNANRSEHTSAVLAKIQRGMTLLALTGVEDRLADDVPRTLAMLKAAGIKIWMLTGDKLETALCIARSLQLGGGVTWHSARPCRGRGDAHALLQALRAAGDTVDLIIEGETLEKARVARLLRARGHVVAAVGDGGNDVAMIQEADIEDDFITVEKRKPKKFNRSDSSEFLPNKRVDRNKNQNEQIEDINTYEVCITSMESLPKQMALAKLLRMENIKGISRIKYKSFNKVLLQFNKEEEANNLLSCQKFKDMGFRCQKVNELSLCYGIVKGVDMDMNENELQKLLESESKIISISRLKRLNADGKWVDSETVRICFEGNTLPTHVYAYDCRFKVDAYVFPVTQCSGCWQFGHVLKYCPTKKKLCPKCGGSHENCDTKELKCLNCKGPHIVLDKTCPLYLKEKQIRLIMSKEQIPYRRALQSLIENREKTTNLSQSSHSPTLFTSIVRGMRTYSDVVSKTPVQREARVFNTNLMEQSGEIALETRSSKETAKNKKPLKTKQRIETTQFEAEQVVETESGASQKEEVEKGNQQDEQLRYRFEFTKLILKMKGILMSEDKLEAKIISVLRMIWEEILKINILQWNAQSLRPKLISFRELLYQENIHIAILSETWLDDESHLSISDQGVSAQEMWRRMRWIKGHRETKSYPPPDKQKELLYSLTPDYVLNSMPTFTSVNESVGIEGAEGRAASLAGDVSVRQLSGLARLLLVHGRRAAMRSAALSLFIVHRGLIVSTMQAVFSVVFYFSSVSLYPGFLMVGYGTVFTMLPVFSLVLDKDIPSITALRYPQLYKQLSKGRQLSYKSFYIWTGISIYQGGVIMYGALVLFEDQLIHIVEISYTALILTELIMVALTVVTWHWLMVVAELVSLLMYIATLLIFTTYFDGDFIRHWEFWWKVIVITLVSCLPLYIVKHMHRKWSDRQYKNIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0H5</accession>
    <name>A0A835L0H5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000351">
        <property type="protein sequence ID" value="KAF9408953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0H5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="424" mass="46360" checksum="2E43A8AA83D6E709" modified="2021-09-29" version="1">MAEDEDGVSNKKSPENTNEGAPSQENEQNASKPDLGIEEAKYNSNENGDASHTEAKSSSKSTGATRKDENPFSFRHFLKRDLSLPGNSTYENTGARPKVYANTVQHSPTKIDVHADSRRDKPRSSDAQAKEKTNEGSSHRISDNTSSSSSVEIPFSVVDNSDSKPNFYTDNNDVPFYHRPNLASEPLGMPSLPDFVQDHILVEQAYLNFNGPISVDLDNLPDFTFNTSFNAGSSSSLGRRNNSSYGGRGYDYGSYMGAASTSNEAGQAGSGMPLDLPAGAEAAGPVPLDLPPHLSLDLTESVNPVDRRNVSPRSNFPLDLPPNAGAESMCLPDFLPVHPGRTSPEPEHQDEQMQQIMAELERTRYGRIFSRTTDADATIARLKNQIKKLKGAPVRTRSAKNTKFQSRPYMMQIFQPLPAYLASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1R5</accession>
    <name>A0A835L1R5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Luciferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_008419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000163">
        <property type="protein sequence ID" value="KAF9413338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1R5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF353">
        <property type="entry name" value="GH16244P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="450"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="61358" checksum="B41380FEF0AD3108" modified="2021-09-29" version="1">MTADAHAKTRITSRVARLKKSASERYKIDEKEVHIGHIALESMLQDPDMICQIDFTTAKEETNRSVAKRTSRLASAMVNAGLKPGDPAIVMGHNHLDLCIPYFACHFGGYPMCAIDPSVGKNDLVRLFPYIFPKIVFCQKSCEEKVREAFKANNLEGFIVIFDDKKSDLEAFIEKHNGTDVDYRPATFDHSKITAWLMLTSGTTGLPKVAIIPFDTLLHGIISWWEPFPDKVESILAMATLQWVSSLIYFISGPLKGSTRVQASEPLNPMTLVQIINKHRPVTTAFTPYLLGHFLNFGEKTCDLSCFKYIVIGGSAIEKPLLDRFKKVCGAFMYLVYGMTELLVPVFDYNDNTPFGSTGKPQSQYQFRLMGDDGKPLEGTYKTGELWLKGDAFFKGYLNNAEETKTMLTDDGWFKTGDMFYKDEQDYYYFVERKRLLIKHYGFLLSPLQMEEIIRRHPSVVDVCAVSLPQLDCTELPVFALQRRNGDKVDTQEIAELLRKNMEGKRLNGGFFFVDSLPVTPSGKVHRVKVKEMAQAAQKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2B2</accession>
    <name>A0A835L2B2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium homeostasis endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_007808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000139">
        <property type="protein sequence ID" value="KAF9414195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2B2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="190"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="746"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9414195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="89005" checksum="9B18396B51F5393A" modified="2021-09-29" version="1">MELPQPPQDQDLRNIIDKLAQFVARNGPEFEKMTKNKQKNNPKFSFLYGGDYFNYYQYKVTTEQAILKQSAGGQPAPAPAGAYMAQNRQYVMPQQAGATPAQLGLAASMAVAPALQQWLAANSAPPGTSQHSHHDLDNISAQINMLKEQITQSENNLNAQHTVLIQQQQAKINELVSKAQVETIQMMAEDNNISLSELDTILQPIIDTCTKDSISSGKGWILQHATSHDAGKVISQHLLRKVTQPGAAFTQKLHIIYLVNDVLHHCARKNAEDLKKNLENVVVPMFCNASIAVTEEQEAKLNKLLRLWESKSNYFETAVIEKMKSPTSSYQEYQNNLISQHSNAIAHLTQQTKSTFENYQTQHQAFVAHTMQQIQQLEMQKHAIELQNSHDQNKDNVQQNNMQNSFQNNSFNDQSFPPMGGYEPNFNANNQYGSESGDNYASNNSLSGNENSYDSQTFDQITNQKKKNEVTEEPDLSILPNINFSQPPPGFIPNENPALLAFQNGLPDLSKPPPGFPPFPEVNNEELMPSVPYFELPAGLMVPLIMLEDDRYRPLDPAKIRLPPPAPPNERLLAAVDAFYASPNHERPRDNEGWEKLGLYEYYKAKNAARKMKEEAVAQGFREKSKSPSPIPKDLQKQPTPPGRRYRSKSKTPEKTSPTKSKSRSPSPRRKSTTSTSWRRERDRENRDSRRRSRSRSRSRSRSRSRERDRHRESPRSRRVERSRSPTPPSFLGGAYPSTSMSGLDASNKGHQLLQKMGWSAGGLGASGQGIAEPISGGIVRDRQDQYKGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L2X4</accession>
    <name>A0A835L2X4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_009026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L2X4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF247">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="12">
        <location>
            <begin position="290"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9412502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="865" mass="94267" checksum="1B6A368F359A7E11" modified="2021-09-29" version="1" fragment="single">VRKVFASFGGSQCLFGSWRLISVRVLIARNDGPSLASHGASRLLQIFKAPACDFRAPAYKKCAECEGVPYSVVAGQQCEAVMALASDIVLVTLLCVVRDGAPARFPDLFPLHGWWTNTERMQDSSDIQVVYLPALLPREAQLASDKQADDIPLPYSFDAFGRNFELQLVPNRRLVSPEFRVWSDQGQEATLSAVDPSCHFQHAGSNAVAAFSACKDHALHGLIVVDNSTYEVRPLPLGSGRAENGSGRTAHVIRRAPPPAPPGDDARLLRPRVRRPRTYPPRLKPGPPNYTIEIALFLDEAAYKIFYPYLNYSESDLRDMLLAYINGVQALYQHSSLGTHIQLSLVRLTLLRSQPSSLPAHAERGRLLDSFCAYQRSLNVDDDDDPQHWDMALLLSGLDFYSEEGGRRNGVTMGLAPVGGVCLPAHACVVSEFGTSDLLGRPYPSAGFTSVYILAHEIGHNLGMHHDGTGNNCARDGYIMSPSRGTNGEASWSTCSARVVADLQWATCLFDGSDDLDAPSELQHERFGGAPGAIWSAKKQCEILLRDADAAPSPSGPAGEHCSQLACRTPHRAGYYYAGPALPGTPCGMHMWCQGGECVPSKALPTSSTTSKPDSDADSTVSGGWSPWREASCQSGCSDRSRGFRERRRVCLKPSSDACHGASYDVVLCDDTKVCGKKTRVGASELASRKCAEYSSLLPELDPRGGGLQAPHDPTRMWMGCAVFCRRASGGGFYAPRVELNDAGKDPYFPDGTWCHNDGSQDYYCLQHHCLPENFKMNAQWHIWELPSEDVSGPFNARALSTPDDEAAAAAIKAYLSLDNAGVPITRSALPPQFPEEPEENWEVIDYVDVPKQRKRSPRGHSPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L392</accession>
    <name>A0A835L392_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_009734</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000223">
        <property type="protein sequence ID" value="KAF9411493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L392"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="69"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="15">
        <location>
            <begin position="344"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9411493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="440" mass="50962" checksum="E0AFCCB3438603B6" modified="2021-09-29" version="1">MTKLFLKTNRIFSAVLSKYKFSTAAKSVASLQIKGKDFVADDYTNVTPKILSYLDRNLHLQKNNPLSIVRQRIVNYFYSSFTHRGHPAFSVYDNLSPIVTTKQNFEDLLIPSDHPSRAKSDCYYINRDTLLRAHMTAHQSELLRSGLDNFLMIGDVYRRDEIDSTHFPVFHQVDAVRSQRKEELFPDKPELQIFEPTFEKTNPHANHINDPMKQSCHTLEATKLMETQLKSHLIGLTQALFGEDIKYRWVDAYFPFTHPSWELEIFYENDWMEVLGCGIVRNEILVNAGPSNTIAYAFGLGLERLAMALYKIPDIRLMWSTDSGFLTQFENVNLNAPITYKPVSSYPQCTNDMSFWLPPNYTIDTFMSNDFYDLVRDIGGDIIEQVKLKDKFVHPKSKKHSLCYSIVYRHLERTLTQAEVNQVHKEIEKAVVDTYGVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3N1</accession>
    <name>A0A835L3N1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000093">
        <property type="protein sequence ID" value="KAF9416265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3N1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032281313" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9416265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="535" mass="59838" checksum="F87CB51DC6B65C9C" modified="2021-09-29" version="1">MLLLTLWSVLCVASVQARPNIVIFLADDLGWNDVGFHGSNQIPTPNIDALAYSGLVLQNYYVTPICTPSRAALMTGKYPIHTGMQHTVIRGEEPRGLPLSEKILPQYLKDLGYKTHLVGKWHLGHYKREYLPMSRGFDTHLGFWTGKIDLYDHTNMETGTWGFDFRRGYEVAYDLFGKYATDIYTNEAVKLVEAHNKSEPLFLMVAHSAMHSGNPSEFLRAPDEVIDKFSHIKDTQRRKYAGMLTKLDESVGKVVMSLRKEGLLENTIILFSTDNGGPAAGFNNNAASNYPLKGVKNTLWEGGVRGAALLWSPLIKQPSRVANQTLHIADWLPTLYSAAGGETSVFKNLDGFDLWEALSNDLPSHRTKIVHNIDDIFASASITVDNWKLHKGTNYNGTKDYWYGPAGRDGEYSFDLLYKSDAAVAINNITALPNKERITSIRDASTIKCNNGKPINECKPLKAPCLFDIDEDPCELKNLADEKPDILQALLSELERVNATAVPPNNQDLNLRGDPKYWGRVFTNFGDYIHLETPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L493</accession>
    <name>A0A835L493_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hyaluronidase</fullName>
            <ecNumber evidence="3">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L493"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9415700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="481" mass="53995" checksum="BE9762106BDD1067" modified="2021-09-29" version="1">MKVFAKRRFEAAGREFMQATLALSKKMRPRAIWGYYGFPYCFNMASNNMKEACADKVPQENDRISWLWQESTALYPSVYSSSSLTTRQLAALIRGRVKEAARKVRGGAPILPYFWYRYRDSGFLNKTDLYVALNTFYKSNASGFIIWGSSNDVNTVDKCKQLREYVTNILGPAIAKYTKQNMRQGDDPEETLGANFNRNNSTTFDPEFNWIPPENYTQTIEEIVDKELKEEKEIGHKNVTESILVDMILNNIATNCGDGCDSASKDMPTDAKEIKEVDSTTNESQVLVVTEDPFKKNSSVITTTVPTTTEEYIYDYDTNVPGDINVEDVDENVDYSDISTTSKDSTTAKTIEVFITTSANTETSTYSISKKETTQWKEESSTPITSTTDIEGFTLRNELNNAIDLNVEEENSIEYSTATPTTNASTTEFSITTYSTIRPNEEEATIENELNTTKDKTDDTVSDSSTTLAPVSTEQVVVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4V5</accession>
    <name>A0A835L4V5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_006959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000112">
        <property type="protein sequence ID" value="KAF9415369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4V5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9415369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="394" mass="44195" checksum="86A6F55E004418D0" modified="2021-09-29" version="1">MSKRDPSDRHGHDRKLDPSDYENLISQHNLFEASRSKHQELPSFPGFSNAETQTKNSDIKEQAVHSGLGPWHYNPWWVLAGAAGTSTARAIPSQDGYSEHSEQTKVKQEPPGPGTPDRDPLQSDLEQFQAETVTPPVGLDSFCDDCSDPFCDSSAAICRKLFHCPHCRKSYPTILEFNTHLTGVHPAQKPFRCQICLEPFYKKSQLRRHLDANHTRKDVNKCSVCSKYIKDKSNLRKHMQVHTGRVPQKQFKCDLCNNKRYMSLDRLNNHKVVCTGEKVLKYCDMCTKVFDNSRSLNSHKKVHARELKCDNCGEQLRSLEQFTNHKMICQGATSEASASHGQASSGHAGVPTMGRCCTQPGLCEHDKPAYLNIPGYAAGRVLDATLSSLKSELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Y6</accession>
    <name>A0A835L4Y6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000309">
        <property type="protein sequence ID" value="KAF9409572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Y6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="73" mass="8420" checksum="03D70F4623872CF1" modified="2021-09-29" version="1">MPPFSLAVRAQYLCTVPTRRHNLIYVTYATIVSLSLSHTGFLPFASHSLRQRLTSEWSRSVICCVFIYKKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L4Z2</accession>
    <name>A0A835L4Z2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000109">
        <property type="protein sequence ID" value="KAF9415533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L4Z2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="273" mass="31391" checksum="9D079F8CDE03EC72" modified="2021-09-29" version="1">MLCNVLLQGWATGYCTRRNGYKFSTKKKCTIHIWGCGDQAQFVMYDGSVAVAFNYTCYLIEEQIDVLRDNLKNTSLGLTFKYIRLKKEHCRKYLNMRGHIDPPPFQGLNFGSGMPPPFGFCRGPDFHGAHRRPGFGPFGHEECTEHQHPRQRHGPREGGRSGGCSCDSDEEERCCGPRNFRRRPGGRPDFMFGPFGPGRHCHRFGPWGGPWNGPWRGPWGPGHRHPWAGRFAPYPWCNHMNESVYDRPEHRRCKKDDTEKCCENKPCCSVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L546</accession>
    <name>A0A835L546_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000298">
        <property type="protein sequence ID" value="KAF9409790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L546"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120457" checksum="D62F978DD2050F6A" modified="2021-09-29" version="1">MTPDPFLDFLPTIRIWKKMTSVKNLVGVKIEYQQEFCIHRKQNVLSRCIIPRILITMNYITSELDEMEREETFRLKRFKQLKYVRVDKGKPDEAILEEEPQPKPKVLPVPQPPKSIPEPPKSIPEPPKVIPQPPKIPEPPKVIPQPPKIIPPPKVEIPPPKIEIPPAEAEYIKPKEKEIIPIKSVCSCHKIPEEKPSVICPPCELEEGETFQPVPSKTVCCKERLEHLKTHINHLIELIEQLNAKEEFPDLRKETIIKSCEAMKIKIEEVSYPPPPCDICQKEPPIPEPPCATVPASTVPSCIPSICSKLAPSAKSSRTAPPEIPPIRSLLLKSSQQKLTLSCFETEYKEIVRITTSLNPDGTLTEEKQIITVKTERRNPMTEDKKGDESYATPCCKNDNNDGGAGGFDGGVGPPTDDVRSCRVVGVCGSGMTERPCGGSQKGTSGDFKDGGGSKADISAGGGSARRLSSKLSFKEGGVCQSKRSALRLAGDNTTKSTCMDSGVCSAPTPPNTSIPPPATSATPAAAICDPCAPPITRKPCPCDEIYGDKKPSIDTIPSIHYSLEIYNPSRDAGMLNANAADENSKAAKSSADVRTCKNCGVCTITDSAPGSAYDIDSWGSMSQCTCDDYQSDAVCGSRCVITEYVTTIYQNGKDNVDACRKACRTVGCGSSYKHTKTFLTGFNPHPPISFHHPPRGVPAASKSTTTSLKHSDSQLASDCTCKASKGTEVEKMTSARISELSSVASSYSSPIAELKDVYCETDAPLCKECVSASTSAQSAWNYPLDKKMCDKSTFCIPNCSTRAGVGNIDNSLFGTGLRRERDLAKPTSFSCNASKISKVKSLTRTGYSDITLKPQTPSDYKNKDAYNEIIYKGCLFNDLRQMIMARSISTQCSEATMVSGMNSSSSYHSQSETTCQRCSTDLRNNPTCYTYLESRDYDLKDERCVYCGTLGQFSTPSASLLSKNSAVQSTASQKTSPFSKSYNSSNSRFSECKSICSVIAKQIRSGCGSPLQSEICCPKPGSVRKVKEVPKPIAKVDAMTSTKRCDRFDCRPLLAFSNNHTCARIRKNVCACHSDSHVCATTQICPILQRSKSCCHNFYRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5C2</accession>
    <name>A0A835L5C2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Potassium voltage-gated channel protein Shaker</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_006437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000096">
        <property type="protein sequence ID" value="KAF9416114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5C2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000012">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="16">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="128"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9416114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61792" checksum="A042582AEF00E9A2" modified="2021-09-29" version="1">MKSVSGLKFETQLRTLNQFPETLLGDPTRRIRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGEQATNKFREDEGFIKEEEKPLPSNERQRKIWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELIVRFLACPNKFNFFRDVMNIIDIIAIIPYFITLATVVAEEEDTLNLPRAPVSPQDKSTNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIARSRPDGAFTFYFAFAGVVVFSSAVFFADKDCNDTNFDSIPDAFWWAVITMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTMGEPYLSPIHKKSSISGESSSDVMDMEEGAMVADPHLEQNLRRLKDEEKVLLEQQATFETGGNDDIGALEHQDAIRLNHNPEIIPDVAGRRDDAAAAVWRGRMPARSPPPCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5I1</accession>
    <name>A0A835L5I1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ninjurin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000121">
        <property type="protein sequence ID" value="KAF9414928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5I1"/>
    <dbReference type="OrthoDB" id="6114058at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF20">
        <property type="entry name" value="NINJURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34755" checksum="4C66205639610882" modified="2021-09-29" version="1">MANDLVKLKIVNENAKSVDQSLNDEVEMIFGRGPARAPALNDKTPVLTNGHLIDKEREHTEFNGNNNNGSDTDLDHPRQPLLERRGGQLPPLAGPETDELDGDPPKDAAPFPGADVSLLNTRDKKPGDHDHDDTERHSELDPSDKHSMYGDDAATDGKWSSGHDETDHPYDVNDLAARFGESRPVSPFSAIALPDVNVNTYQQKKNLAQGMMDLALLSANANQLRYVLESASTHPYYYPSLTFISLSIIFQIMVGVGLIMNSRYDVNDQKERCKADKINNMTVIGIFLITIVNVFITSFSVATQTLPVTTTVQQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6E8</accession>
    <name>A0A835L6E8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006475</name>
        <name evidence="2" type="ORF">HW555_014031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000820">
        <property type="protein sequence ID" value="KAF9405066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000097">
        <property type="protein sequence ID" value="KAF9416063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6E8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9405066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9416063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="195" mass="22356" checksum="93ECE1D72422A307" modified="2021-09-29" version="1">MVTVLNFVEVLVMDFTSEEKLYSINKIEFFEEWLKHEKDKRCDRLFEFISTKFNFSDITEECEREIKMKLASISSKIATRWVSSGKSKERFLNKNKLWLEGQEIEFCVRSTLPQPSTSTAELSRPGRPRKDFEDASFKTKKRRVEDLVQSRSVGELMTAAEVAARSTGQKNVARVIKDIGENPASAKSDVSGIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6P9</accession>
    <name>A0A835L6P9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_002804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6P9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9421092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="170" mass="19379" checksum="E451ECCE820B50D6" modified="2021-09-29" version="1">MIRSCGLTATGCDEVSGTYGGVRRFPPHLYEARPQLSAGTNRHVISDAATRHPQVSPSYVTTLQNFLVSVYHVTDGQNFYDIEEFYKPIVFDNLNRGGYNITDCLSELLNCWEVIKPDVICTYDKYLTTVCDLLKETCDDYDGLVEEQLGLRLTLFENKCLWSWQEEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6X1</accession>
    <name>A0A835L6X1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HW555_002647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6X1"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000002">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000006">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000173">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="373"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="478"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9421432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="601" mass="67246" checksum="5EE1F2F6F030A039" modified="2021-09-29" version="1">MSSEELNIKRKMARQNGIVQPLLTDLYQITMAYAYWKSGKVNDVAVFDLFFRTNPFQGEFTIFAGLEECLKFLENFHYSDSDIQYLQQTLPENIEPEFFAYLKDLTCKDIRVSAIEEGSVVFPRVPLLRVEGPLIVAQLLETTLLTLVNFASLMATNAARYRMVAGKNVSLLEFGLRRAQGPDGGLSASKYAYIGGFDGTSNVLAGKMFNIPVRGTHAHSFVTSFSTLDDLHSVIIRHAETQNPCNLLELSIEWRKRVSAVIDISPEEASDGELAALISYALAFPSGFLALVDTYDVKRYNFQGLPSRHRQHNMNGHSGYNSNCGTNGTRVLKSPTIHSPYGYSTVERTLRSGLLNFCAVALALNDCGYRAGGIRIDSGDLAYLSVLARETFESIAEAFKLPWFSKLTIVASNDINEETILSLNEQGHKIDTFGIGTHLVTCQRQPALGCVYKLTEINGQPRIKLSQDVGKVTIPGHKEAYRLFGADGHALIDLLQRSSEPAPEVGQKVLCRHPFQESKRAYVIPSKVEHLYKVYWKDGIIHTMPKPLHEVRQRVQSSLKTLRQDIKRNLNPTPYKVAVSDDLYNFIHDLWLQNAPIGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6Y0</accession>
    <name>A0A835L6Y0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HF086_009370</name>
        <name evidence="3" type="ORF">HW555_002677</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000024">
        <property type="protein sequence ID" value="KAF9421462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000438">
        <property type="protein sequence ID" value="KAH9637702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6Y0"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9637702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="69" mass="8185" checksum="90D574C4EC338CFB" modified="2021-09-29" version="1">MTRGNQRDLARAKNQKKQQEMQKKKNASEKTGMSLQERKHRDAELMREKQRKKEEQLAASMNKQKQTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L721</accession>
    <name>A0A835L721_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L721"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="357"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="493" mass="57851" checksum="B6341B6175C14372" modified="2021-09-29" version="1">MFQFNQGMDSYHYHKCIIIPEKDVLDVDIVGTGQLSSFRRWWNDLFLLSYDCDRSKGFYTSSNALRIERYRQFRKHKKCIHPLSKFRKKSFLNFCEKKLFFHVSSALPLHWFLFLRYGEKVNCGPCKCNKFICALKIIGVFGLFRVMESSTCWCHRRYPKVMESICKFLRIATVTIVTLIQLTEMSDVFSLLLYFHNDYVDEDSMLSFRAGLKYGWNVDNFIFFMFDIGKMLKPLTRITQINATVERFVIDKLFSFLGFTITYILYAWAMVECFSFLTLVISAESQRMNSKKKTMNVLKSLQVSDELALKVSEYFKYKSSSLKLTEARNGLYAVLPQMLKNEINLSCYFNIILRIPLFTQWPIPVLEQLTIMLKRKEYLKSDMVTVAKVSGDGLMIVHDGVLAVYSHKNKELGHLIDGDYFGALSLVTDKEVYMTYVVAVTNTTILFLGKMEFRMFMKDHPQLFYGFEMDLKKRYKDRARNQDYETLDGSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7L5</accession>
    <name>A0A835L7L5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7L5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032769695" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24972" checksum="E08A1F077926D2DD" modified="2021-09-29" version="1">MKIESILFLFLTTMFNTSQYETTQSIRAKLPNMIIVNPRVKIEGRKVFLEKIADNLEEEEDHDIDFHFEIETAPTATQKELILPPQPVPKFPLHIAWWPTTLCFELDEDQVTHKLWISNRTKRPIFFHCCGLWNDTARYGASWCCFPRTRFWLPPGLSAPLYIRATPRELSPIPYAVTFLQIAAAHLRDNVTGYFSIPIKAKFLKYIAPSMLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L8M0</accession>
    <name>A0A835L8M0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_001701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000014">
        <property type="protein sequence ID" value="KAF9422707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L8M0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9422707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="603" mass="67046" checksum="F8AB2F698B5DE7A1" modified="2021-09-29" version="1">MEEQTNRAPSRMERGESRVDDLHLDRVVASQPEIGPTPPDGGYGWLIVVSAVIYHITVPALLSLYGLIILKGIREEGHEDNEVLKIWDVDIALVPVIALVIRLLLESWCRAVVKIFHMPRFMALSGLCLTVAGVLLSSYSTDAASNDHIVNTFSGIFAGIGCALTGQQTEVIITHYFREKLTMAQRIVRMAPSVGNCLVPILIGYLCSVYTGDVVVMIYGAIIMQNCIFLASYTRPIYIEKVIRHTYNMLREAVEDEDEVIFSNQARKSEAEAERKNIERNEPTSSQGEPSNSATVEEDGTDVVVFNSRQNAKEILDPAIQYRENRSASKQSRFSSDFSTMYDTGTNRFSSDFGALDITSYARVNGYQELENIDRQAPQPLYRETTVNAPTNSVVFAAEVSPGTARRTASLKKNFFTITNMLKDINFYLYALLHLCTTFSILVLGLIFPPLIWEQNPSMNIWSVSTLIAAAHGSALCFIMLCVVLPKSINEKARLCAAFCVAGAMGFYGIALSTNKSLLVVWCMLASFSTAASSILQQPLYNSTLNEFDTTATMTASNTIVAIFIISWSLIYNYDYKTCFLTASVLQTVTACMFFALSFRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LCS9</accession>
    <name>A0A835LCS9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_003899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LCS9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="357" mass="42031" checksum="470A651DF01BC841" modified="2021-09-29" version="1" fragment="single">TKRKRLETTKGDVKASNYINHRQNVGLILEHSTILPFKSNKGYFNCFYCKKQYASFDQLKAHVTELHENISFKSILKSIHRPRDRIRADVSDINCRVCKKKIETIDLLIQHLTDVHNVKFNFDSDSFFFFKTLTNHMNEHSTDHVCDVCGRCFLLADRLRAHALTHKESAAKCEYCGKICSSKMLLRSHIRYKHKKLSFMCSICNKTFLTSQKRVEHLEEVHKRKPLNLTCRICSKKFDYHKSLYSHMRSEHLHINPEPRYACAVCGSMFKTKYGLTYHMVVHSGEKNYECEICHKKYGRRKTLIQHLRIHMNDRRFACGACSQAFVQKCSLKNHIRVHHSDMDYKQLIIDKKLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LD05</accession>
    <name>A0A835LD05_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LD05"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14537">
        <property type="entry name" value="PTP-MTMR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF110">
        <property type="entry name" value="FI17948P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9419890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="708" mass="79672" checksum="2632ADD796F14E42" modified="2021-09-29" version="1">MNEKKLVQNFKSYINVSPLSKGEKNGSLQEVKPKLLNGELVTGAAHSVVMLTPLSEWDRGRFGSLFITNYKLSFVPLENSTNDEYCQRNYLLGAFDVPLTGVGAVWLTDGGPQRRRRLMPYGDMPGKVKGLQVICKNMKVLTFSFANSPIDNGRKIALALMHHAFPKRHDLLFAFEYREPYYPTLPSDMNMFQRPGDWKRELERCECPHWRITCINGTSDAFMLTAGETLIVPSSVLDYNLMESARHFRSGRVPIWVWGRPEGAALLRSGELLSTEQSATAESVLLEQVRRSHPKLTPPHVLYLCGNTFTNAGGPGILPPLATLQSSYKKLVELCTPTTLGQFWMQDSQYYSILDSSRWLRYVANCIAFADDAAQHLSNNVTVVLQEGDGVDYCSVVSCLTQLLVDPHFRTITGFQSLIQKEWIALGHPFCDRFGLPRPGNPKDSTAKDTTSAQTAPVFLLFLDCVWQLIQQFPADFQFTETYLTTLWDCAHNHIFDTFLFNCARDRELAVARNFVQRPVWDWGEQFSEQDKALFYNPLYGIKQNTVPSQRLSQPTFPSKGAAELPRLEACTSVAGMEVWSQCYERWLSPLDAPLAGAVQYHVHNYAALKHVRTSCTLLPPCYSTGLLLLIMLQIIHQIKEKLPSLSIMSERACNGETEPPARRSVPRFYPFSLSRGETLSPGLDAMQLSLIDASQLLDSQSLLNAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K1DCY6</accession>
    <name>A0A0K1DCY6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemosensory protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CSP4</name>
        <name evidence="3" type="ORF">HW555_000176</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2015-01" db="EMBL/GenBank/DDBJ databases">
            <title>Putative chemosensory protein genes from Spodoptera exigua.</title>
            <authorList>
                <person name="Liu N.-Y."/>
                <person name="Dong S.-L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KP729023">
        <property type="protein sequence ID" value="AKT26481.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K1DCY6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036294013" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AKT26481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="123" mass="13496" checksum="52BBC50946A292D5" modified="2015-11-11" version="1">MKCIYVLSVLLAFAAVQAEDKYSTENDDLDIEAVVADLDTLKGFVGCFMDAMTCHAVAADFKKDIPDAVATSCAKCTNAQKHIFHKFLLGLKEKLPSDYEAFKKKFDPQGQYFEALEAAVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0C3</accession>
    <name>A0A835G0C3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_014059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000840">
        <property type="protein sequence ID" value="KAF9404991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0C3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9404991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="116" mass="13336" checksum="8CD71B0B204F4638" modified="2021-09-29" version="1">MSKGWILGHNEEDAAQNRVTLTKGETSDDYILFYQQTCDVPAIPYDFGRCDVVYRGESNEKIYRIQISSSWPPPSYIYTEGLLTNVGQVRIVSQWGERLYAIVRMYGKIIEDNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0D2</accession>
    <name>A0A835G0D2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_014047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000834">
        <property type="protein sequence ID" value="KAF9405020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0D2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000221">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="464"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9405020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="690" mass="75543" checksum="6A898D9A9600BF82" modified="2021-09-29" version="1">MSFAEEAEQELIRLMIQNRNSAFSRLEKSNQGEAIVIKFLDRYGEPTSPKHLAESLNLSSARIAVVLGSLEKKGQIARTMDPNDRRRINVTLTECGKKVAKLEKKEMRDKIVQIFKQMGEEDTKKFIELTAKFVDYSQKLSRKEEDVGIQQGGLEYSTPEKIRKTTLQGIEMFMTDDEKKTIEENYTLTTQKVDGKEVDVYKLDLQDGMTEAKLADIFDLPMMMLASSQAKDSTDAGEAKKILDDYTAISKDAAKAQQLGEEAAALGEQAKAAGEAAASATDMATAAEKGAEAQGLAAQAQAKGAEAQTLANSIKTANDAMPTKVEAAREATEKSLGDLGSNSMRTVGIQLTLAEYKALDVNTQQIQTDYMIKTVGDMMAFITYTMMIVMAFMMLSMVSIILPRANVAAGRVEEVLETVPTIKDPEKPKDNHDFKGEVKFEGVQFRYGDADEDVLHHINFVAKPGQTTALIGSTGSGKSTIVNLIPRLFDVTGGRITIDGIDVREMTLHKLHEIIGFVPQKGILFSGDIASNIKFGDAAISDEQMKKAAVIAQAEEFIDSNEKGYSREISQGGTNVSGGQKQRLSIARALAKNPKILIFDDSFSALDNKTDVALRKALSENIKDATQIIVAQKISTIIHADNIVVLNEGRVVAQGTHEELMETSNVYQEIAQSQLSNSELGIEEADFFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3R1</accession>
    <name>A0A835G3R1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000563">
        <property type="protein sequence ID" value="KAF9406661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3R1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="137" mass="15651" checksum="FDFFAC9A35A30382" modified="2021-09-29" version="1">MIFPKDSEKRQKWWSVIPLKGKFYESAKICSLHFKPENYDPLRPKRLLNSAVPVDSVQLCSCGNNVMASTTPFKCSASSNETIPTHNTHSENIVVDENEPPAKRRRLKDFNVQCKIKSLGKSVWKKRKKITTKSCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3V7</accession>
    <name>A0A835G3V7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferritin</fullName>
            <ecNumber evidence="7">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_013162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000585">
        <property type="protein sequence ID" value="KAF9406483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3V7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000014">
        <property type="entry name" value="28S ribosomal protein S6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF43">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0409">Iron storage</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="177"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9406483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="354" mass="41336" checksum="1D205F5DF18BEEA6" modified="2021-09-29" version="1">MPTYEVALMLRSMPKPELKTTLKRISHAIFDRGGVIRNIENLGHRPMPYKTTAHGLVHKEANYFVFKIDTATKAVADLKEEYSRDVDVIRQRVFKSEESCSNHCTLEEELLPPAYRDEVKKMIEVGKTQVNRFTYKFKYNSGLDYYPFQKYYVLIKLGFKEQVHRIPAHSRRYCSQNYCNSRIEEALNRQIKAEQQASQNYLNMAVTFLHPSKSMIGAGGFFMKMYYDELEHMHKLINYQLLRGGVPLISGLEPPNKHKNLTMLDAFKLGIHMERDLTILIEKGIKLAEEVKDYHYADFITSAFLTEQIQSIYELDQHATNLTTLKCNDAFLLLYDMELQKKYPLPHDIKKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4F3</accession>
    <name>A0A835G4F3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HW555_013935</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000774">
        <property type="protein sequence ID" value="KAF9405254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4F3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007198">
        <property type="term" value="P:adenylate cyclase-inhibiting serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007208">
        <property type="term" value="P:phospholipase C-activating serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
        <property type="term" value="P:serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000299">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000310">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="64"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9405254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="451" mass="50222" checksum="2CE3C60AB4A9FBD1" modified="2021-09-29" version="1" fragment="single">DPPFPTSSEWYDGNCSWVDAVAWGCNGTINGTSTNSTSTDVTSFVLMAVTSVVLALIILATIVGNVFVIAAIIIERNLQNVANYLVASLAVADLMVACLVMPLGAVYEVSQGWILGPELCDMWTSSDVLCSSASILHLVAIATDRYWAVTDVDYIHIRNEKRIFTMIVLVWGAALVVSLAPQLGWKDPDYLARITQQQKCLVSQDLAYQIFATMSTFYVPLAVILILYWKIFQTARRRIRRRREPPPPRPTSADGAPPSGRPVQSARDRRFVKKRFLNLKKCNQRTRAETLAAALLLTEGQSTSTVDTLDEEPRTTAFTINEKAPASVSPEKSSSTVTNGSKPERAIVPAPTHREKKESLEAKRERKAAKTLAIITGAFVFCWLPFFIMALVMPICQTCVISDYLASFFLWLGYFNSTLNPVIYTIFSPDFRQAFARILFGTHRRGRNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Q2</accession>
    <name>A0A835G4Q2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000376">
        <property type="protein sequence ID" value="KAF9408555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Q2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="534" mass="59507" checksum="59CB7AF3D38F5629" modified="2021-09-29" version="1">MSVLKDVSEGQTQAPSPSQPKFSCYGCGAPGVYRSNCSTCKKSSSPVKKENVAFCAVDAPEETHSRPVVFVEVDGQKGTAFMDTCAKMSVASYSLYQSLLKSGCKFIEKTVDLTLADGIKKEQVVLVCKAVVNLNGRNIATRFIVLQEARDNRTLLGVDFLQKAGVVINMPQYTWSFIDEPDLHYELYPEEFTIFESTIIKEMMTLPSPLSAMTVTDSEDTASVCNAMPTPPSTPPPAIMTAGEPKTPTEDQQGITDYKLALIDLTSTPPSKKKPRLFDGYSPSFTDFMMRDAQINVHRENAELSPQSNSLFDANNWDVRIDSIDVVAHITPDQDKLVNQLLEKNNDVFNTKREPTKLIEHTIKTVDDKPISEHGEERRKKYVDKQRREDRGYNPGELVLATIHTLSNGRRRDGPYIIKKRHGPSSYEIADPQKADVVIGLLYSPCGREDDPESKFWSMAVRQGERKNAEDPGTRLHLLDHRRDAFRSRGGDCNITNPNNARAHDASYHRYVIPGVASPQRLPPPCAAPAGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4U1</accession>
    <name>A0A835G4U1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_011737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000370">
        <property type="protein sequence ID" value="KAF9408647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4U1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032306691" description="Cuticular protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23943" checksum="8FFF217B8AF3EF29" modified="2021-09-29" version="1">MCSVILYCLSALLASSFAAEMQWTPYNSLLQQYQQASSPFQEAASNHDQQFQASDYSGGYDFGSSGGSHDGGSYGGHDLGGHDFGGHELKSHVYPVHQHVEEENPEPIKHYKEIVVPLPKNVEFKINQPVIIPVPHPIPIQVPVPKAVVIPIIKEVSIPVEKSVPYPVEKVVHVPKVKEVPFEVVKHILVPVEKPVPFKVPVYETIIHTKKGQHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5J1</accession>
    <name>A0A835G5J1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000658">
        <property type="protein sequence ID" value="KAF9405952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5J1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9405952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="44" mass="5295" checksum="A5A6960733CAA462" modified="2021-09-29" version="1">MMFAFIMLPSEILLQKELEILKRTCDTIAIYWIACKRLRNIFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5K1</accession>
    <name>A0A835G5K1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000329">
        <property type="protein sequence ID" value="KAF9409220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5K1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032322033" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="216"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9409220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="532" mass="58277" checksum="D95322DF76ABF654" modified="2021-09-29" version="1">MRVAWARWYWIVIFTTCAARTASDWLDCAHISTCKCKWSSGKKTATCASGDLRRPPALSSDIQVLDLHDNPLRNLPQEDIFRGNERLRQVVLSSNPLTTLIADQFPPLPHLRILLLDGCRLRSIHTNALRNLKSLENIDLRRNQLTFLRLITFSLPALKTVSLSGNPWKCDCRLREFKDWFLESKLGTEDLLCVEPSTQAGNKWRHVSSESMSCPPEIKSSTLVVRAEIGLPTTFGCWVHGVPKPKVTWLFDGVDVHNSSVECDMEETETSVEDDTEDRVPGSVRWVNVTLLNVTSSAAGEWTCVAKSTAGEARAIISLVLPRSQTATARTAPGIPHLLGVVFGALGILATLGFIAAVACWHLRRRTVPPSRSFTDQEKRLIDASVVVSCDRSIGDMASPCDFEMTERMSDEPPRGCGFDPVHITIEGTPGAFPPPPAEFAVPVPYGNIFISVQVAGRGEPAKYPDLLSGGATLPRRNRTCCAVPAYDNMGPRVTATGSSTWSLPGASTENVEVSETPVLTLPPPPPEFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5U8</accession>
    <name>A0A835G5U8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_012084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000406">
        <property type="protein sequence ID" value="KAF9408110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5U8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9408110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="660" mass="76639" checksum="53609CB855259F7B" modified="2021-09-29" version="1" fragment="single">MTKKKISKLTHAECLERKRMAERKRKEKIRNDPVKLEELRRKERERYHKKKAEGKILPLSEMPPRARRVQQKRNREKRALLENTKQANQICETINDERISPSILPRSESPIPTTSQIQSFNQQMHQKSSRILRSQKRLQEETSEDIPIECISETNSVKDRSRREPLSLALWIEQSSTPAYPPCSPPIAPNVSSIHLPVSTFALNSPKSDVSTNSFVLRRELNYKLRQYQRRKSAEIMKLRETIIKIKREKEMYRKRLNRLQQITKISPKHKNKLTPGFIKKKISPEKRKIHNLVKSFYEDDENSKQCPGKQDYITRHKLKKQKRYLTDSLKNLHRKYLDSGLPPISYVTFTRLKPFWVLQPSLNSRDTCLCKPHANMDLLISSLKHNKIIHENSTSEVLRSLTCNQTKVECLQRKCDKCKHKIIKYSEFDNSNSISYYIWEKGTKITSLRHDASSVWAHLIPILREVKEILSEVCTIHFVSDSPSAQYRNKKVFYLISQLKNYLPNLTCVVWHYCECGHEKGAPDGVGGVLKRSVDRLVAFGKDVTDIDSLVQTLKTVVTGVKIEIVQEHEVIEKDELLPKNLKPFPGSMKVHQIVWTKTSTNGLAMRSLSCVEPGCLYDTIRCCHGKHMGFYELPTEANVQEEVEIKRDVVLLKSSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G6G2</accession>
    <name>A0A835G6G2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_010883</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="JACKWZ010000292">
        <property type="protein sequence ID" value="KAF9409866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001111">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001197">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001219">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001000">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001015">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001564">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="201"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="299"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="395"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="493"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="599"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="696"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="793"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="888"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1222"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1398"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1510"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1684"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9409866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1775" mass="200973" checksum="FBCDAE7F2719EC9F" modified="2021-09-29" version="1">MMRRVAPQFSIPPPPKSEVMLGGNLTLKCVAFGSPMPTVKWRKGLTKWLTPEDNPPLGLNTLKLEDIRESANYTCEAASVLGVIEAVAEVKVQSLPGPPTEVRPSEITATTVRLTWTYSGPEEPQYYVIQYKPKYANQAFSEISGVITQYYSVTNLSPYTEYEMYVIAVNNIGRGPPSAPAVITTGETVDSLYGGAKPGSAPRNVQVRPLSSSTMVIQWDEPETPNGQVTGYKIYYTTDPSQPMQSWHSQMMDNSHLTTISELTPHTVYTIRVQAFTSVGPGPMSAPVQVKTQQGVPSQPSNLVAVEAGETSVTLSWRRPAHAGDNIVSYELYWNDTYAKEHHRKRIPITETYTLNGLYPNTLYYIWLAARSQRGEGATTPPIAVRTKQYVPGAPPMNVTAVAVSPTAVRVSWQPPPAERANGRIAYYKLLCVESGRGDSEATVVKLNQTSFVLDELRRWTEYRIWVLAGTSVGDGPASYPVTVRTHEDVPGEPQDVKVVAINSTSIHVTWKPPQEKEKNGIIRGYHVHVQEVRDEGKGLLNDPMRFNVMDDTTLELNVSGLQPDTRYNVQVAALTRKGDGDRSTPVSVKTPGGVPNRPTVNLKVLEREPVVSIELEWSKPSQTYGDLLGYRLRYGVKDQPLEEVNFPGTKIHSYKINDLERGVQYEYRVAGKNHIGIGQETIKYWLTPEGAPKGPPTNVTYRFQTPDIISITWEPPIRADRSGQIKKYDVQFFKRGDQSSVAEKTTELTKAVFTGLEEDAHYVFKVRAYTDQGAGPYSKDMTAHTERDIGRAPMSVKAVATSESSVEVWWETFRSRKKIIGYVIFYTMTPVEDLDEWQQKSVHVTHSADLDNLEKFAEYAIAVAARTADGLGRLSEKVTVKVRPEEVPLHLRAQDVSTHSMTLSWSPPLRLNPVSYKISYNAIKEFVDSLGMTQTQEIPRREIIVKHDRTSYSINDLSPFTTYSVNVSAIPNDDSYRPPTKITVTTQMAAPKPMVKPDFYGVVENEILVILPQASEEYGPISHYYLVVVPDDKAHNHKHPDQFLTDDLIKNNVRTDDENAPYIAAKFLQRNILYTFHLGNDEMYEGFLNRKLNPSKKYRVFVRAVVDTPQKHLYTSSPFSEYLSLDMREAPPGEEPSRPDPKDIHVLFIFKRRRQPCKAPDQAAVTRPLMSADVGFGAPSDPVEMRRLNFQTPAMISHPPIPILELSEHIERLKTNDNLKFSQEYESIEPGQQFTWDHSNMEVNKPKNRYANVIAYDHSRVILQPIDGILGSDYINANYCDGYRKHNAYVATQGPLQETLADFWRMCWELRTSTIVMMTKLEERTRIKCDQYWPSRGTETYGMMTVTIAEVQELATYCIRTFQVERNGNSSERREIKQLQFTAWPDHGVPDHPAPFLQFLRRVRALNPPDAGPLVVHCSAGVGRTGCFIVIDSMLERARHERTVDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVICGDTEVPARNLHAHIQKLMRVDPIENITGMELEFKKLANMKADSSRFVSASLPCNKHKNRLVHILPYESTRVCLTPRDGSDYINASFVDGYRYRAAYIATQGPLPDTTDDFWRMLWEHNSTIIVMLTKLKEMGREKCHQYWPSDRSVRYQCFVVDPIAEYNMPQYILREFKVTDARDGSSRTVRQFQFTDWPEQGVPKSGEGFIDFLGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSTVLERMQYEGVVDVFQTVRTLRTQRPAMVQTEDQYEFCYRAALEYLGSFDHYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G720</accession>
    <name>A0A835G720_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000494">
        <property type="protein sequence ID" value="KAF9407223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G720"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032377881" evidence="1">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="243" mass="27345" checksum="6A7C8F2D6B21AA4E" modified="2021-09-29" version="1">MKLFAVFVLSCFGFTLCGAQVINRVRLVDHTSYVINFITKTVNTVEDKGWYSFKLPDYVQYVNESLLTSPVVGKLTYHNGFVVSVQHVDIQQSTVQQVWGYNSASGDTTVSVRGTLRMHEVAIGYDVIAELDDDNEPYHYTMTFVHPMITYAFSVSFILFVIHDAYRGNLSVTVLGTVSRVTNRLPSFIPQDSVTDIITYVFDPNAELPAGMAAWGPEVFQPITYELVTKEIPFPQFCYNCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G772</accession>
    <name>A0A835G772_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_011668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000363">
        <property type="protein sequence ID" value="KAF9408751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G772"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032715255" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9408751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="67" mass="7889" checksum="1FB0841BEF29D719" modified="2021-09-29" version="1">MANTKALIKIMIFLPMIIMSSLRLYKNCERCDIPAEIIKTQSKPYWPWMPGYKSDQPGYVWPLYFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G779</accession>
    <name>A0A835G779_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000265">
        <property type="protein sequence ID" value="KAF9410388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G779"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="560" mass="60215" checksum="21897B8C92DD12E1" modified="2021-09-29" version="1">MCYAVGGCAGAGPAASYVAAALQFFAASQCLLQESYPRHAHVTNGSQYDFIVVGGGTAGSALAARLAEEDRFSVLLLEAGPNPPVESIIPGLRQTLKETPYDWNFTSVDDGVTSQALASHVQRQPRGKMLGGSGSLNDMVYARGHPQDYYEWADIAGEVWNWTNVLDYFKKTEHMTDSKIVGNEELMQYHGTGGAIEVAGAHYPDSPNSKMMQAFQELGFAAVDDMTYPYKIGVGKFSHTVRAGRRDSSLTAMLNKVKSRKLHVLKNTFATKILFEGNKAVGILADSDGRELHVYAKHEVIVSAGTFNTPKLLLLSGVGPSHILNQFGIDVVPRSARGTRSAGSHSIGAYLPQKDKDANIPYFAIYPSCVPAGQLTSKLCMQGIGFTNEICGKLQKENELHELIVAAVVLLKPQSRGNVTLKSVHPDVDPAIYSGTFDDEADLEGFPEAIEKALSLVNTTHFKKLGARVVDLTPESCVGLQGAARTRCSVRALALAAWHAVGTARLGAVLDAELRVRGLQGLRVADASVMPTMVRGNTNAPVVMIAEMAADFIKNQYGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7J6</accession>
    <name>A0A835G7J6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_011536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000351">
        <property type="protein sequence ID" value="KAF9408960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7J6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9408960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="501" mass="56189" checksum="C8408BE186C7F573" modified="2021-09-29" version="1">MSVYLLLVSSPTQYFWYRTTLQISEDINYPETFNYKIALALVIAWILVYLCMIKGIASSGKVVYVTATFPYIVLVIFFFRGITLKGMSDGLIHLFTPKWHRILDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPVDNNCYRDAIMVSMTNCLTSMFAGIVVFSIIGFKATMVYEKCLDVRNETLLEVFGPAFRSMVLPEAGQTVRVDLNGNLTSLVMPHLPECDLQKELDNTASGTGLAFIIFTEAINQFPGAQFWSVLFFLMLFTLGIDSQFGTLEGVVTSIVDMKLFPNLRKEYLTGGLCLLCCLLSMGFAHGSGSYIFLLFDMYSGNFPLLIIAFFECIGIAYVYGVKRFADDIQLMTGTRPGIYWLICWKYLSPLAMLSILISSFVELATEGSGYDAWIKSIGDTERKTWPVWAVLLVLVLILASVLWIPVVAIARYFNVPIIDDEERAWFPAEELRDFHGIEPRPVSTTETLLFCTRPDGSEGCCWPGCCDTDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G7T7</accession>
    <name>A0A835G7T7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Decapping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000331">
        <property type="protein sequence ID" value="KAF9409193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G7T7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37696" checksum="BE90785AB96D3583" modified="2021-09-29" version="1">MADTGLRMNFAALKRADPYAREIIDSATHVALYTFEENEWEKTNIEGALFVYSRNGEPYHSLVIMNRLSTNNLIEPVSKGIELQLKEPFLLYRNAKCRIYGIWFYDKDECVRVATKLNSLIKESLKQVPGENMPQNPVYNAATPAAAPVDIFSMLSKAQDDFNSNKGLAANKCDSTPSRAPDMTSQSVMDFFAKAGSGAAAAQMPAVSSLPSPGIFGPRPTDAREVPQLLQRLMSNPAHSVEHIEKQQRSVTPQEAQSSNGNMSMDSTIRQNCGFPLKSTPIDKPNQQRLSGMKKGQLDSTDTNGIIPLESELNLMHISSPKPTSPLATYLNQSQDISHTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G817</accession>
    <name>A0A835G817_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FGFR1 oncogene partner 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_011618</name>
        <name evidence="5" type="ORF">HW555_011269</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIKE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000324">
        <property type="protein sequence ID" value="KAF9409325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000210">
        <property type="protein sequence ID" value="KAH9641868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G817"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
        <property type="entry name" value="SIKE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186:SF2">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186">
        <property type="entry name" value="SIKE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
        <property type="entry name" value="SIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9409325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9641868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24462" checksum="E8538F986008C7AD" modified="2021-09-29" version="1">MSLTIQQIILDAKRLAGRLKERETEADALLTETQTAYRQIHTMKQYKEEIDTLNEASRDRPRGALIGSIERESRLMRDVQRENGELRAALEDHRRALELIMSKYRQHTEKRVWESRIDFTNAINEKQQELIRQQAERINEMTSIMYKAVTLDENSDARKEEELYQRLITENKGLREMLDLSRRYGSDRPCVPLTEDKDVQTDGPPLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G871</accession>
    <name>A0A835G871_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_011201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G871"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07357">
        <property type="entry name" value="HN_L-whirlin_R2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06741">
        <property type="entry name" value="PDZ2_FL-whirlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000167">
        <property type="entry name" value="whirlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033028">
        <property type="entry name" value="Whirlin_HN-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="293"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="413"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9409426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="658" mass="71571" checksum="8503C4875FBF6116" modified="2021-09-29" version="1" fragment="single">CRRYATDQRLVTASSTQGVMSSATAMHIAVPTKSRLLCRRVQLKMGQSEQLEVGVVGNSYVEITEFLKVESIVTPGMRSGEAGEGSELAEFGARWPPPYNQGYGWTRSATPQHPPAHHLARHSRSHQDNRHTSYEAEDARGRARGGVYYSPPGTSYTIVERPASSHGHHSSYSHHYAGKLSRAPYLGSTTIANSAAGATSLRNSTNHLSAANGKKRPISPEQVLRLFGQGGAAALGKALPPSHPPAPLPARRHSPASSPSSTTHHAIYRGGERERPYSSGGAPPPPAEPATRTVTMSRDPADSHGFGICVKGGKEAGVGVYISRVEEGSVAERAGLRPGDSILQVNGTPFSGISHEDALKMLKSCRQLTMTVRTAGALVGRASCSWMDRYGRPASPPPLRPPRSSSKDRSVRRVDLCIEPGQSLGLMIRGGLEYNLGIYITGVDKDSVADRAGLMVGDQILEVNNQSFIDVTHDEAVAQLKYHKRMSLVVRDVGKVPHACTAYGERDAAPRISGWGKRRGAAATAVEQKARSLLPQCDLPAIAYYMEEYASRRLTPDSFLTVVRDLLDTPQKYTLLTEIREFMLPEDRARFDELVYRRGEEPVDHHIKRGPERHMLPSSTMHELHDPEGPAEAPLVADHRSPSEDSGLGLPPHDHAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8C4</accession>
    <name>A0A835G8C4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000275">
        <property type="protein sequence ID" value="KAF9410148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8C4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="27540" checksum="A35325AEB85C648C" modified="2021-09-29" version="1">MESEKVSKTSQKGQSQQPEPSTSTGSVTSRPRRGRPSGANRVPLTLEERRARNAQYERERREDFAAAQTELAEAAGCDPNASTINLMAFVVTKLKNASEDLSIEEYQRINANLEAQIASCFERLGPEFVLSGDEDDVEADDSNTRKRKLSQETSRDEKRMRPGTEQVPVSGSGPMVSTTDLAEAEPSFSGTHSLLPSSFFQLPTPSQFAHQTPSPLLQQETALEQEIALRFSQDDLLQIYGALEFEDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8F7</accession>
    <name>A0A835G8F7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase HW555_010644</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_010644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000273">
        <property type="protein sequence ID" value="KAF9410207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8F7"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9410207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="215" mass="24403" checksum="7551BE5CA20FC8D8" modified="2021-09-29" version="1">MDDSELDPSELGTQEYWQRSYIREIENFEESGDSGEVWFGEDSADRVIDWICNCGIEKDTAVIDLGCGNGYTLTELAREGFTNLTGVDYCQEAIILAEKVSQAEFPHIKYKVFDITQDCVKELGKFGVVHDKGTYDAIGLNPEDPKTCREKYIEQVHNMLSDDGLFIITSCNWTEEELIKHFSEKMKLKRVLPTPQFRFGGKVGSVVSSVVFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8I7</accession>
    <name>A0A835G8I7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_011712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000368">
        <property type="protein sequence ID" value="KAF9408679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8I7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9408679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="330" mass="37585" checksum="9443E8668E482559" modified="2021-09-29" version="1">MSKEVQKRWRSIRDSYTKTYRQGKCVLPEQCPPGSRRYQYHHQMSFLLKALQNKKPRYSQDKYESFSEISNSPQHPPPEDIPKIKNETMDKPLDLKTKPEERPETQDKCNQADCIDKPNSLEIKIDANSILPEDHFDDDRLFMNSLIPLFKKMNDDTRLLCRIEVLKIIRYALQGHKCFEALKVAEDSFVKDRLSNILSKDESNVSTSTQKSPESKLAMTTRSADGSFAITFAGANEKEGARASQKDKAAPSDSDEEQTAKKRLPKLKVCESPCEEDSYSHVTSVAQLSTPMFMKIYNLERSKIAPALPTTPPIQVSIKTEPVDPEPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W0</accession>
    <name>A0A835G9W0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_010472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097003">
        <property type="term" value="F:adipokinetic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15382">
        <property type="entry name" value="7tmA_AKHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF59">
        <property type="entry name" value="ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9410470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="46673" checksum="850CB4DA99B4ADBB" modified="2021-09-29" version="1">MDIDEKVSGPGGASQKNWSHPNASDELPLDMRFNHGHMVSMTVYSVLMLISATGNLTVLSQLMKRKRAGRASRLDVLLMHLAVADLMPKQRMKLLAVLLQVTFLMMPLEIAWAGTVQWLAGDLMCRVMMFTRTFGLYLSSFVLICIAVDRYYAILKPLNVTWEARVRRALIIAWVCAGLASLPQSFIFHVEEHPDVKGYYQCVSYGSLPTECHEFAYFLVNMILMYVIPLLSTLYCSSAALLEIIRRANTSNDKMRRSGVGILGRARARTLKMTVTIVLVFFTCWSPYYCYCLWYWIDKESLKSLDPAIQKAMWLFSCTNSCANPIVYGVFNRNRWSWRAGRNVRCRSGSMRRGSRLPYGESMEISAATLARARNSMGSERNGRRDSYNAQNGSQKHWNTINNNHVGNGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9W9</accession>
    <name>A0A835G9W9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000243">
        <property type="protein sequence ID" value="KAF9410862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9W9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06729">
        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11859">
        <property type="entry name" value="SH3_ZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000029">
        <property type="entry name" value="tight junction protein ZO-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865:SF28">
        <property type="entry name" value="POLYCHAETOID, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="64"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="353"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="3">
        <location>
            <begin position="625"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="797" mass="89556" checksum="0021479EBE620EB4" modified="2021-09-29" version="1">MTLELKNRWVNNDVVAYLPTVYCELELCEIQSVSWPYKMMMLTKKKVTEASVTAERSAGWETHRVRLNRVPGYGFGIAVSGGRDNPHFASGDPSIAVSDVLRGGPAEDKLQVNDRIVSVNGVPLENVEYARAVQVLRDSGATVSLVVRRRAPAPPPTAPTTIKLSLTRNGKKEDFGIVLGCKLYVKELTLRAREQLNQGGQGLCEGDMVTRINNTPVTDAMTLKEARKLIESCKDRLNLVVTRELIREETVTNGNYQNNYNSLEATPHNVYGAAEASPGYSSSGQNLYVAAPVRGGDARRGPMSHEQLDQPPRPPPPRNEDYYSSRRQLYEDEAMNNQRNKPTNEPRLISFQKEGSVGLRLCGGNRSGVFVSGVQPTSPAALQGLQPADKILKFCAVEQVNDMEMKGVTREEAVLFLLSLQERIDLIVQHSPDEYNAVASGQMPGDSFHIKTHFHYTEPTDGEMSFRCGDVFHVVDTLHNGTVGAWQVYRIGRNNQEVQKGTIPNKARAEELATAQFNATKKEMSGNDGKHNFFRRRRSTHRRSKSLGKEHWDEVVLSDSISKFPAYERVVLKQPGFVRPVIVLGPSRTSPGNDCSLRALINSLHQVQMDSTLEDTKTKSAGIIRLSSIRTIMERGKHALLDITPNAVDRLNYAQFYPIVIFLKADNKHIIKQLRAGLPKSAHKSSKKLLEQCQHMERVWGHVFTHTITLSEANQNTWFSKLIDLIQRTQQQQLWVSETKPYLKCLCNRYQQNIPMAFGQMEVVWILVPILRGCIYISKIRKHDILTNWFLFCLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GA56</accession>
    <name>A0A835GA56_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000295">
        <property type="protein sequence ID" value="KAF9409835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GA56"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032747886" evidence="1">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9409835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="15910" checksum="00E1BE83D4686AA9" modified="2021-09-29" version="1">MYSKVFITLFIFYLSAVECNDIHVGYLNSRSKKIYSELKEAVPALWKRTDEITIKAPSHEVIDSIHVTDLRDDKDGEAYITGGGVGMTYVTIDLKSPSILRGYKFQIEVYGSRSGFYDPIFGTGNTNYGEGQQQQYPRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAB2</accession>
    <name>A0A835GAB2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000227">
        <property type="protein sequence ID" value="KAF9411367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAB2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="32002" checksum="9C84DDEB0141162D" modified="2021-09-29" version="1">MAVEIQLLNEIEKHELLYNYSLPEYNRKDMAEEAWEEIAANTNMTISDCKEKWRNIRSSFLRSIKPNGFKIKKPYYLTEYLRFIVPYLKPTSSAIESADDTIYQSPQHHTNETETLVIKEEPNENDENQEESNDNETLSVLLRERPAIARKRRRIISARKPYEDLRPSELSKVRPVRTKPITGVDRNSDINPNYNAMKMFLLSLLPEIETMSEDQVRLFKIKTMMLIDDIKVNYEQLRQNTSSINSDRLQKRLINLLLKNLETSTKDNTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAQ2</accession>
    <name>A0A835GAQ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000235">
        <property type="protein sequence ID" value="KAF9411077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAQ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="8854" checksum="8E931368896BCE7C" modified="2021-09-29" version="1">MDGCLNILATDYPTIKFCRIAADITGLSRHFRVDGVPALLAYKGGQIIGNFVQLATELGNDFFAVDVERFLIEYGMLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAV1</accession>
    <name>A0A835GAV1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of G-protein signaling 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_010651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000273">
        <property type="protein sequence ID" value="KAF9410214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAV1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000162">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.60:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047017">
        <property type="entry name" value="RGS6/7/9/11_DHEX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040759">
        <property type="entry name" value="RGS_DHEX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF6">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="G protein gamma" evidence="3">
        <location>
            <begin position="800"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="884"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9410214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="118911" checksum="C06F50896981AAB5" modified="2021-09-29" version="1">MVTMNSSEKAASKACQQGPSRDNSKCIKEEKEKDREKKDNSALPPGVQALMSTIPSPEESPNYLVYKKMEAIIEKMQDENTGVPVKTVKSFMTKIPSVFTGTDLVAWLARHLNLEETWEALHVAHLLAAHGYLFPIDDHCLTVKNDNTYYRFQTPYFWPSNQWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQKMFSRKWEFIFMQAEAQSKVDKKRDKLERKVLDSQERAFWDVHRPMGLYTCNNMVISYHYMFLEKTLLICGLNVNQIISHLEEDDDVFAADIFITPPDNWQNSDEDSGDEEFASINNLSRHQLLAEAELRVTRSSQPESRIVNELVGDEETVHSIPSTSSVSQPPQPISSLTVTQPPPKRRRVEVTRKWRFVDIPEKSEKEYCEPDFLENLENPVQFFELFFDEEVFELLRSETEKNAIQKGKHAFRITTTDIKHFIAILLLSGYNSVSRYRMYWEQRVDCSFPTVAALMSRNRFEDLLRYFHVADNNNLDPSDKFAKVRPLWKLLNARWVKYYPGDKNLSIDESMIPYYGKHGTKQHIHGKPIRFGYKSWSICTRLGYLIYGELYQGASTGNTHPELGVGASVVLDLISKLPQGSYSFYFDNFFTSLPLLEELQKMGHDGTGTIRANRTEKAPLKDPKEMKKTMASTQCGSEPISKVKRYCDKQKKDVDQPRCFVNYNKFMGGVDRLDQNPGCVNTTEIDPKKLSRINALKAKRLRQCQELILQHNLKNNPIVTITNPQESEEEIQKKNDNNVIKENGETSQPEISVTCVPEVSVKPPTIEQQIEAARRQVSMLRTRLERRNVRVSKVADMFIAYCEQYAEYDAFLTPPEWPNPWVSDTTDMWDQEKQCKEPLPLRRVRRWSFSLRELLQDNAGKEHFAKFLSKEFSGENLKFWLAVQELKALPIRRVAARAKDIWKEYLAADAPSPINIDAASRELTRQKVESGTADRYCFDQAQAHVYHLMKSDSYSRYLRSEMYKDYLNGSKKKTSVKGIRSIVSFTARKETSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAY9</accession>
    <name>A0A835GAY9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HW555_010575</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BAW_Kor-Di-RS1</strain>
            <tissue evidence="25">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 27">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000269">
        <property type="protein sequence ID" value="KAF9410296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000020">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="263"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="638"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="880"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1170"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1184"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF9410296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1195" mass="137131" checksum="B2D6438B3DB80A07" modified="2021-09-29" version="1" fragment="single">MHDTNITQELNDNRSDQPRANTDTHTQNIQRNCEIDELFAQTLQFYSETHPTSRCYIPKQRTSKKLAKIVDYINQVILPDYVIRDIEFPELQTIIYSAAWTAAKVNGSRINLSSTQDRNNPRKDYKPKWQKRLERKIDAIRAKLGRLTHYIQGHRSRKLEIEVNKILRDYRIHTTHEAPNTHLAHYLDTLKQKLSVYKSRLNRYIKCTLRKTQNNKFRNNEKQFYRTLKKSTTNHTTSSNTANTLYPTGENLRSFWAGIWQNPVCHNAEAEWIRAEENQNFSHIEVAVNERLRLTCGLKPSVEKSSVLWYKDGVLIDTQRSRLVQTKQWYRCHTCAEGDRVRDEYQNMTGLKSTRLRIKSFRPKDVGVYSCKVDNDDAKELSLRISQKHNTQDFEGFQADMGESVPPESLSQIRTAALVDNNTLEENATDSKRYSKDDDPDEKGEKDHPNYGHIDEKQEYFPPRFKHPTKLYNMDMKPAGNSIRIRCAAEGNPTPNITWYKNKSTPISRMFFQPSYGKWSMGMEELTKADNGNYTCVVCNILGCIEHTLALHVQERYPSKPYIKERYPGNVTVLVNETATLSCPPVSDLEPYLYWIRPTNYTVHDAEVGPSDMPIPFGDVIEVFIQCFFHGERLYAKPVLTAGADNQTVLVGETARFSCQFLTDMHPSVYWMYFTRDENINNVTVDPSDVKLQQTMVYYDKNKVVTSENPEDKPEQLTIYNVTKEDEGWYVCIALNSLGNTTAKGYLTVLESPPVLEAPDHGKHTLLINILTVVLGAMFFVAAIIVVMICKKLKREKEQKQLAIETARAVIVTHWTKKVTVEKPQMNGSPTATGEALLMPVVKIEKQKLQQVQNTTNDSMMMSEYELPMDIDWEVPRDSLCIGKVLGEGEFGKVVKAECIGILKPGMQSVVAVKMLKEGHTDAEMMALVSEMEMMKMIGKHVNIINLLGCCTQDGPLYVIVEYAPNGNLREFLRNHRPGNRYESPTEDLKEKKTLTQKDLVSFSYQVARGMEYLASRRCIHRDLAARNVLVSDDCILKIADFGLAKDVHSNDYYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVPGQYMYQHLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVEDLDKILTVTANQEYLDLGLPQLDTPPSSYDGSGDESDSDFPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB86</accession>
    <name>A0A835GB86_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_010026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000235">
        <property type="protein sequence ID" value="KAF9411078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9411078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="719" mass="80289" checksum="E83FC2995F8939F1" modified="2021-09-29" version="1">MSQVLQKLRNVDSNDSDAVKEAITLFMQNLLKHVDDNNNVWLRALEDVLTRYPRYCSQHRPMIEKFIVHFLGSSNYYNVIVAAKCAHALQQIRPSQDKLASPKNCWREQMSILCNTAHTLIEAIFSNTINIYKNNRSVKKKDVELLGNSPLTIALSNILSVKKTHGSSSEEKKMVLCNKLRNVFVFIQAMLVLGPNLIPFSGLVFRFVMQTLKWSSENPSDQSRKVRITAYNSLSKWLSILHAHRVSGEGRARSWEDDLTKHIIQDITPPKKIVQLTMSNQYTKNLSKKAKRKLANTMLQQSTIASHMPGEKNKIDVSEESSDEVANAALDCAETFLTVSGIFLKPTTHKMFQERLVRECYNLDSYSVERSMSLLRALEGARKNTPTNVPPPTQYCLQLYSVLIRKFSSQALLDIRLHLHCSPPSINFAIDAPTESKAPKNKKEISKKNREALEALLGKERMPPTRSTEDSTEAPATKKPRLDDDRISISSESNASLVISDGTDDEIEEINEKQTGGDVTIEEEIEIVTEQGDTQDQAREHSKQTSDTPCMTVDDSPEPTNGDIIVPNETSIFDAKTQVPMNTSHDTIDGDKSPTSLEIVYDAPNTSSKVAMIEKMDDDNLPSTNETDDVQITCGQAIVGSQGSESAMNNVEVEVEVSTTSQNGTNEVVESEETVDTTQNDNETANKNIEVTITSKEVTIEDMLADFVDEVNDEPSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBH3</accession>
    <name>A0A835GBH3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HW555_008202</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">BAW_Kor-Di-RS1</strain>
            <tissue evidence="24">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Endosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <location evidence="18">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000153">
        <property type="protein sequence ID" value="KAF9413624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031904">
        <property type="term" value="C:endosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000135">
        <property type="entry name" value="LDL receptor protein 1, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000155">
        <property type="entry name" value="Low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000189">
        <property type="entry name" value="low-density lipoprotein receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF9413624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="4472" mass="496551" checksum="5BD9D4DBED4F9B96" modified="2021-09-29" version="1">[encoded data, 4472 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBQ5</accession>
    <name>A0A835GBQ5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Venom acid phosphatase Acph-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_009148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000193">
        <property type="protein sequence ID" value="KAF9412310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBQ5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF205">
        <property type="entry name" value="GH28721P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49432" checksum="9AD2FBDEA9B43BBD" modified="2021-09-29" version="1">MIAQKTRKEQLLAIVNVVKSVVHLHRKEGGREEEPTNAAEAAPAQGMRIEHTCCCLGVLVGISLIAALVAVILMKDSTIEVTELRQVHVLMSHGERTPSEGELAMLGAPPPDHVFSPYGAGAMTNEGKMLTFEMGALLRKRYDEFLGPYYESEKSIVISSDTELSKMTALLIAAGLWPPPAEQVWNDTLPWQPVPYTYPPRRQDFLLYEENCPRYKQEKERILKAFTEEGLLLPYRDFFHKIAQMTNTNFSTPQEAYYLNNLFLIQDDIKVANPKWAKHVKRKLMDVARLEYSMMFHNNLLRKLSGGALLQQIIKEASSITAGDSQVRLVVRTGTPVSVAALLGACVAPPPRLPDPGAALLFELHERRPSPQSNKEQKTLAEGQRFGFKIYYWDDDSAEPRLMEVPGCSAFCPLETFKELTKYIVTHNYNKDCRLVPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC20</accession>
    <name>A0A835GC20_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_009965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000233">
        <property type="protein sequence ID" value="KAF9411192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC20"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="586"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9411192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="777" mass="86128" checksum="EAFCD8D20B623C90" modified="2021-09-29" version="1">MTGNMKINVEQVYTSVACNRTPEITDWNGQGVICFGATNSVVIYDTNLRGKDPLKVLSHHRSQVNTVKWLRKADGSCTELISGSADKTAAIWTIEDGVWKVTNSLAGHTDGVTCIHGIYNGDELLVYTGSIDSTVRVWERKNGVTVHKQTINLSSGLCLTLHAHILPTSHKPILFCALDDHKIHVFVGDEYHRAHILTGHEDWVRGLDVQDVDKSTIMLASASQDTYIRLWRIEKHVKQQFIKGIKVEEKVFPAYGEDWSVKLEAVLAGHEGWVYGVQWQPPAIRESSKKPVYRLLSSSLDKTVIIWEPESSPSKGEGEGVWVERVRVGEVGGNGLGFYGSKFGPGGNSFLAHGYNGSFHIWRCCKESGQWQPSVVCGGHFSAVEDVKWERQGRYLMSVSADQTTRVHAPWRTELGTEWHEIARPQVHGYDLSSLALVNSTTFASAAEEKIIRVFKAPHNFVQNYRNITGEVIEGDSGGPEGAAVPSLGLSNKAVFMGDEEQGDGDDDNDGYFVPVDMTEPPTEETLMQHTLWPELQKLYGHGYEVYSLAASPDGTLLASACKATTAEHAAVLLWDTTSWEQKQRLVSHQLTVTQLAFSPNSQYLLSVSRDRRWTLYQRQQETDSFEIVANTDKTNSVHTRIIWCCAWTQDSKAFATGSREGKVCVWSEMGPTNTSLGAYGLLGKALEVNIAVTALDFAPHEGSGLILAVGFETGIIRIYNFTDDGWFLLQELDNSATHHLAVKRLTFKPTEGNKMLLASCGSDHLVRIYSVNIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GC45</accession>
    <name>A0A835GC45_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Caudal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_008656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GC45"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9412959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14154" checksum="DAC1375EF0EDF84B" modified="2021-09-29" version="1">MVNYVNPLAMYQGKGGQYGSGWYGWQHQNFEDQQWCAWNGAPAGGEWAPDPHHFPKREPGEREIADLPSPARGDLASPSEGSPGSRPAQPPAPPRSPYEWMKKPNYQTQPNPVMKTDGESVREKYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD80</accession>
    <name>A0A835GD80_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_009364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000206">
        <property type="protein sequence ID" value="KAF9412009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD80"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="85" mass="9896" checksum="10BD59C14695DCE6" modified="2021-09-29" version="1">MGIGVHIERICVGKQRKQLIMISNYTFARTTTDDRYWNCSKKYSTKCPAKLRFSDSGALLHYELEHNHEPPSYFKTKAGHYVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDP9</accession>
    <name>A0A835GDP9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000148">
        <property type="protein sequence ID" value="KAF9413876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDP9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9413876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="484" mass="54247" checksum="5290E35A276A0BF9" modified="2021-09-29" version="1">MVVYWTLDVLHPSALAIMPIGISCVMSGVGMSFISEIYIRNDLLDCIGVMMIIIAIENSMVHRRIAIKVLLVFGCSHYRLSFLLFFTSMFLSMWISNILACGLMMPVVKAILAELERMGIVEVYQTIGKATQKSNRHEQNLPRPTNFTVFYFLGIAYSSSIGDMATMMGSQTNQIFKVYCETIFPLGPKIEFPHFMLLNLPGVLVMETLLYMWMNFAFLGMFRTRSDVEVGLTEEESQYIDTLLATQYHQLGKPSFHEIAVSTIATLTALLQATISTAHIDQTTKGSPNFHKHLRVSSPCALCVVLLFVTPVNLEFLRYFKKQTAGSSNLFESLRDSEMLLEFEKFLLIFKGWPASALVFIVVLFCKILTEFASNFSVVYALLPSIAKVSVLCDVNPHYLMMASTLASCLPFHLVTGAPVNAMVSAYVNIPPWKMMYAGLGPSVISVIVVWFTVAVWSNAIWTDITISPQWAHTNIFGILNKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GE51</accession>
    <name>A0A835GE51_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_007909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000143">
        <property type="protein sequence ID" value="KAF9414080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GE51"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="130"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9414080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="344" mass="38839" checksum="474E11DD5E97EB0C" modified="2021-09-29" version="1">MNNLKLTRSHKILALVPEKNACSEGSSSSDEETNVYIPPSPDTSDPPSLASSLEGLNLLDSSTESNKEQIDISVDAPLTPIFNEVFPSPTTSNYNILPTLNSIQSLPTPTVEQSSPQPGTSRQQLPLTRSKHRYFKIRPVMERIRQNFLKVEEEGKYSIDEMMIPYKGRKAGKRKQYVKMKPKKWGFKNFVRAGVSGIIYDFLLYGGDDTFRGLTFRDKEASIGLGGKVVIALCQTIRQKPAIIYADNFFMSLELTHILREEYGILSLGTIRTNRLRGCQELLPTDQQMKKKKRGSSAQVVCNKNKLAVVKWNDNKVVTLISSYIDSHPIETIKRYDKDEKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEK7</accession>
    <name>A0A835GEK7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HW555_008649</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BAW_Kor-Di-RS1</strain>
            <tissue evidence="25">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 27">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEK7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000373">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000384">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="179"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="467"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="552"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="731"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="946"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="738"/>
            <end position="745"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="950"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="964"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="20">
        <location>
            <position position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF9412952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1277" mass="144926" checksum="76E775074D6D450B" modified="2021-09-29" version="1">MSLLPLSLSDYPRQNGPIISPCQTEITLEAGQNFTLICRGKTPLNFKQQEVPEEVIGPFRIEQKNTSNLDDESTFETVLELYNVDRFAIGYYACYDDTVNGSDILNNLIEEPNNTEHIAFIYIYVDGTDSLFAPLREVIVPRQQCKLVIECRPTTPDVEVSLTSDFADIIYEQYNVRVPPLPIIQRTSQLFLKGENFTLSCSVAYRPDTVVNLYWELPTNDSVQYDSNEFENLRDILFKNITIINATKDHAGRYVCVAKNNCGEKSKPITKEYLTEPRLKLIPVNTNPVITKLKTVRINTEVIDYPTANFYFLRNNLSLPLDDEGNPNKYDVTRNPTTGDVILSIFKTNVFDSANYTLVASNKYLKKNYTYEVLIKSKPTIDFGLNVDKKYLQNTMASLQCQPSTEVYEHTKYTETAVIVIPVHASGNVSCQASNTESTATETRRLLVYEIVNGFGIRNSERTWFSQNEDVTITCIASKYDFYNVTWIGPDAEDLRGINTVEYSKNEFSLMAKLKFPQISLNHSGVYTCQGSKMNMNIEFDYINITVAPLLPPIINQPVDDQTIEVVTYQEVELTCQAEGVPPPKLEWYKDDVLMGNDTNAKIFIHEIGHTMVNSSIRIDRLVEENKGTYECLASSDGLTASRVYTVALKASSYQLYLSIILVVIFVLIVVVLYLMWRVRKDTQFRKELKASGLLYFNEGATKSLNPDLGIDEQADLLPYDEKFEFPADKLILGKQLGAGAFGVVYKADARGIINAEETTEVAVKMVKKTADNMYIKALASELKIMVHLGKHINIVNLLGACTKNVVKRELIVIVEYCKFGNIHNYMQRHREVFIDQLTDNKEKNLGRINRGFSSSSGSTGAHSDYFASCTQDTDHTFVNSANTNRSTRKVSEGYVQPEWRTNYESDYSFDGRNPRPLTSRDLLVWAFQIARGMEYLASRKVLHGDLAARNVLLAEDNIVKICDFGLARSIYKNDEYQKKENCLLPVKWLAIECMTDRIFSTQSDVWSFGIVLWELFSLAKTPYPNISPAHLLQWLSEGKRLEKPPYADDRLYNVMMRCWEQKPTSRPSFTQLQEILGGFLEDNVRNHYVDLNTAYMDMNVKPGGEDYLAMVCAPDYNNLVTPSPHHYVNDRSFFPTTPTQIDEEGYLQMSPASRQNIFSPRAQDMKFDFDARKFNPRVSEASSCGSELTPMLTLNNLPARSGSESDHEGNASPYLNMCPRIDEEADDVFETNQNNAKNALNTAHTNPTYISLDVDIEKKPKDIINSYINVPNGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEM8</accession>
    <name>A0A835GEM8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_008679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEM8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="203"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="495"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="584"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9412982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="780" mass="89434" checksum="6C93BD4F7F87A520" modified="2021-09-29" version="1">MFQNWILPKDKMQGTIKELLDALGCSLEADTVLDYIQNDPNYGNSNLSSKQVNEYAQRLALKASNAKSFLKKYEELRNRNTDNLADIIALFYKLVCEEKKSKISKPKVAPKPVLGDNKHQITKDDLPQIKDKLLKAVDESKKLVMKSFEDKETKLRPNWYSSLDLPSWQKDHPAMSWDFPKEPTPIISSLSGVPIASQENIIIDDLLYIFSGVPGNYIVHQPVKDTYDPRTFLISDDVDDALKQIVQQMLPLASNYSIVRRFIEHCDMWSGQVLHALVAAIEILLKDYYTMIAQLETEHLSGNLTLQKLWYFVLPTMHTMQVLAAIVTNIGKSELRGGAVLTVLHDKTNTLMGDARAQEISLFLTERACRPYLCILDQWIHKGTIVDPFQEFMIEDNELINKEELPVDYSADYWEKRYSIQRDRVPKFLDKFTDIILRTGKYLNVISQCGKPITKTNTEEIKYSLREQNYGAIIQKAYAYASKSLLELLLKEYDLMGRLKSVKNYFLMSQGDFIVQFMDATEQELSKKIDDIIPSKLESLLGLCLRLSAASHDPYNEDMKIELLPYDLQFQMFKILSIETEDEKVVDKLWVWLYNKVVKRFSAARLYADAFALRQRMLSCIQHLQYYMCVEVIEPSWCQLIQSLDKVHNVDEVLERHNDFLESCLGDCMLTSPQLLKAVTTLCLVCVQFCTFIQDAGCGGTATSGSADSFSRSVSRYGLRFTAALLSVLAIIERMARDNNTNKLLNISARLNFNTYYVKQLEKFCSDDKLLEAEKKQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEZ3</accession>
    <name>A0A835GEZ3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEZ3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="379" mass="44635" checksum="F56767EBD62A177D" modified="2021-09-29" version="1">MEKLCFEFTVLPASDGKSSICCLTSIATIGGKVYALPEELQSVSHHKELIRTTVFNKVKNSLKKRYQTRRVWISMNGDLKKTYLDEDENLQFEDQYLEEVQVKTAVAQDTQTGVFEKLFEQLVQNTQESKQQNLKQITEKFLIEKFTSKNPNANRWIDTFEKECTRFSITEDDKKIEALRLFMDKCCTDWYNSMIIKYTIDSDWTTWKNIFCETFTNKGWTQISYALSFKYRDGLLLDYAIKKEKMLLEMRNSIDTGTIIDLIAVGLPEHVLNRIDRETLKDTVDLFNEVRKFEYLVNKRSYSFYRKHSGNSKGYNINDRNEEKNSCKICETLNKGIRYHPESACWYRTKEEEKPKVKNIRHVNNSVIEAQLNEAEQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GF54</accession>
    <name>A0A835GF54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Colmedin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_006360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GF54"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF85">
        <property type="entry name" value="GLIOMEDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="321"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="7">
        <location>
            <begin position="545"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="546"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9416201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="88771" checksum="85AA86F9A61F973A" modified="2021-09-29" version="1">MRNSPKRKVSTDFEPFCCRKLSVTACAFAVFSLLVQTYNFFDNGEVNFDLEAKKLMKNVLEESIEEKVEEYFVKISGSTSHRLKREAMLKQSVNQEDNTVTPHVEFFNPKMRSELEEKDAAEMRRTGAKGPAPGGDTWVWLTSYSRYKVVQGFCKATQDYCPPGVQGPKGPTGLPGPKGERGDAGAPGTPGHAGSRGPVGPPGPKGERGFPGNPGLDGRDGVPGEPGLDGMSGRNGADGAPGKDGRDGVPGRDGSPGKNGKDGKDGRAGAPGPPGMRGLKGDKGPMGAKGQRGNDGRDGAPGRPGLSIYNYTLEKELFIPPTFAQDQTRVIVREGDTMRISCNPMGRPEPTVEWRRYDGTAGSWRDASVSGHVLNIPNVSRWHTGKYVCLANNGMQPSANQTTDVEIQAWPEPVLAWEIDGITLEGLRYKTEVAPTGDPWRWIMRLEIPGVRDSDLRQYSCVAKNELNNQTVKGHIKLMSKSRTSSPADTSTTARRVRLPAPYLTSYEELCEVQRCPTCPRCDRAQLLITPMNGTAGLKPRRNTNCQLYAIGKPVYHRYKEEMFGAWLRDSNGSEAQRDKLWTTQETDVERLREYRSKASFKADHVDEYHKLQKPFFGNGHVVYSGSFFYQANESGHPGEIIRYDLTQSRIKSVKLPNADGRLYTTQHNQVDFSADDNGLWAIYSIESSNNTAVAKLSFDPNKDGLNIDYIWNISLNHKQVGEMFIVCGVLYALDSATERESKVSVAIDLYLNKQVEVALQFTNPFRKTTQLGYDHMHKELYSWDRGNQLTYPVRYNELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG19</accession>
    <name>A0A835GG19_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000111">
        <property type="protein sequence ID" value="KAF9415411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG19"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="496"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115507" checksum="8ABF6677C6DBC78D" modified="2021-09-29" version="1">MEYHYSDLCMPTDHLLTGPYAAEYAPQYLVPKQSAEYEVRSSVLVDGGDRFGVSAVVFDKFEELIWMGNQGGHVTSYYGPGMQKYTSFQVHESEEVRDIITVEQGIFALTKTTLRHQIRRGIPKRTFKSPNMTDMQCLFQVSATKLLMGGHQNKLIDLDLNRMTETAIPIQEEGCAVLRSGGGSLVACGSANGMVALRDIRTPTTAEHTFRAHSACLSDLDMQGDLLITCGFTQSVGMAVAEPYVLVWDVRCLRGNSKPGEGAWSLPTVSPPLLLHFLPAFSGRAVALSGDGHVALLHVNAPNAAEHSMFQVDTQSSQCSVMDVSSTSQALVFGDQSGHLHLFSPQHNHEPVFNNFSRATEFADQVLGIPYVGFNDTTFQFSTVPLPPLTSGNKWFNELPEEFFKRIYRKPKPIDPEVLKSMKMQGPIGYAPNPRSFKRNQMPYIEDNLDDLNSSRQNENKYVAQPIPKHYQKIDIRYNKHGPNDELEKLNRTGLPGLETTLPNSYCNSMLQVLYYTLPVKATLLAHTCAKEFCLSCELGFLFRMLDTSGGAPCQANNFLRAFRTVPEAAALGLILPDRGPDSRVDLVALIQSWNRFILHQIHYEILETRKKEKALIVNSPPKPVRMPALNVKRPVPQPNQVNGQFSEEYQYTELEFLGPATEFECTEELREEGWTAREDGAGDADSVPVDNHELPNNQQADREESEISQLFAIGRHQLNRCMKCNKEEGRESVVLACALQYPTAVREGPEPRGGFLELIRASLAARRSTPAWCEHCSRFTPTVQRGRIVRLPPILAINCGGATVREKAYWAKGAQKEMPETKRGGGGKPCRYGLHCARPGCHFKHPERPSPQAGSSKTPAQESNCVLPQQLLIRLQSDGDVLINDKLESPTEPHTPNNRADKHKKKNVTTQSEEEYTLSAAVVCVEDNPKNLIAYIQTAGKDVEPVWYLFNDLSERRRSGAVWCVVEDAVRPVLHGQHGARPRRVRAALIALATVWAAEQWCYRKPIRYERDVLPGTGRDATALQLRSINSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGF5</accession>
    <name>A0A835GGF5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000104">
        <property type="protein sequence ID" value="KAF9415696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGF5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="510" mass="58275" checksum="A40E1554CA3CEC7C" modified="2021-09-29" version="1">MCSQRLKRLLLPLRGKSLFTLKVEDAIKSQKNAVDQIISVTSDQIDSPSRQDTPVHFSKYFTNEDLQQMTEFIENSDEETSAAQNHIKPSECTRTHAPTVTHTASVILPSNSHDPILATITPQSPMMSMVSSGIRNDISIESPNFSSVIAQAIAQLDCDISPAPTPNVVMPVSSPMPIQTPITDNALSDIEPSPRRRLSTRKKDKGRLRMVHQDQWLDVMRKKNKNLGNAYKSRNGKMRKKKEMGPCCGEKCKFKCSQKITNVDRDLLFVAFWSMGDIVRHWDFINKYCDKIPKRRVTTETASRREFTLRYYLPTKIDHEVHETDSVSPKPQITKIQVCKTMFLNTFGIKQGLVYSALKKLSLQGTVVHDKRGIHRHTKKITEEMIASVCDHVNSFAPVESHYVRKRTNKVYLDGSLTFARMFLLDSQNQIKEPHKIRQQSTSSPSSKNIDPSLRGKLPIPEAKLQDLKYLCRNNIIPSVYHDFYMIQECPNSFMKRLIYIDLHTKSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGX5</accession>
    <name>A0A835GGX5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000124">
        <property type="protein sequence ID" value="KAF9414811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGX5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="661" mass="71415" checksum="60F5C950A766AC53" modified="2021-09-29" version="1">MMYVETLNAIMDKQNMQFCLQGLRNTFQIRLLFISSLLRPYLGLKTPLSYQYHYYSATDYTRSADKSTMPCCKVSVKKSMVCSISECICIPTDGKPYLCLSKNEEGKIVPCFDCKAVQVDGTEWKCVDTSCICLPTEGKACLCICTDEEDTIKSCDDCTCINAEECKKEFKKCNKPGCVCLPTDGKDTICVCKKNGKIVLCECNGAGTCGSATCVCVSTEGAKCVCLCCDAKGNIKVCKDCTCDSKKKDSLICNKEGCVCIITDGKPCICVCKNGEGMIVRCDDCKCDDSGKCDKPECGCIPTDGEKCVCVCCDEKGNFKVCKDCTCEVKEKEVLECNKDECICILTEGRSCICVCKNSEGKIVRCDDCKCDASGKCDKPECVCIPTEGAKCVCVCCDEKGNFKDCTCETKDAVAPKCSKTACVCILTEGKSCICVCKNSEGKIVRCDDCKCDASGKCDKPECACIPTEGAKCVCVCCDEKGNFKVCKDCSCETKDAVAKCSKTECVCILTEGNSCICVCKNSEGKIVRCDDCKCDDSGKCDKPECVYIPTEGAKCVCVCCDEKGNFKVCKDCSCDDKEKVAPKCSKADCVCIVSEGRSCICVCKNSEGKIIRCDDCKCDGSGKCDKPECACIPTEGAKCVCVCCDEKGNFKVCKDCSCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGY7</accession>
    <name>A0A835GGY7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin complexes subunit BAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HF086_013094</name>
        <name evidence="2" type="ORF">HW555_005140</name>
        <name evidence="1" type="ORF">HW555_006793</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000107">
        <property type="protein sequence ID" value="KAF9415585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACKWZ010000064">
        <property type="protein sequence ID" value="KAF9417843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000693">
        <property type="protein sequence ID" value="KAH9632722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGY7"/>
    <dbReference type="OrthoDB" id="10021571at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9632722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12186" checksum="FE02A618520ECDFC" modified="2021-09-29" version="1">MNNSVASSAAKVGEIFTEAGAAFNKLADLAMTLHPIGESNISQQPKTPVKKKLVEERTIASGSIPAHTQHNIHTAPLSQQVTLNMLNAQETEIDADGLGGDVKLEFESSTDEVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH13</accession>
    <name>A0A835GH13_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAB6A-GEF complex partner protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HF086_006260</name>
        <name evidence="1" type="ORF">HW555_006877</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000110">
        <property type="protein sequence ID" value="KAF9415455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000499">
        <property type="protein sequence ID" value="KAH9636445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH13"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9415455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9636445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43213" checksum="41527E88CBBC191C" modified="2021-09-29" version="1">MIELSAKLTTGTVYLAGEALECCISFCYTAQPEHRNSQSHYDALENLAWASAQIHCFYSTSKNTGDKTPTIGKTTSLEVTSCDIGDVIFHTKPKILFCDLTIPLGETKTFWYRESLPIEAPPSYRGTSVKYSYKITIATQKVGSHIKMVRIPFRVLPISPIMNMQDLAALCGNETTEELQPTNPFSEERKVETPLTMALQVLQNLTARRSPNSYMITNTRGKVGRFCLFKSAYKLGEDIVGTFDFSVGTVTCMQVSVSLQPEEVIKSKSPSKNMNKETSSRSMTVARYHEVTLGLTQSQLILPIPLHITPAFEVDDVSLSWRLHFEFVTTNEKLLPNPEEKDWTAPLNVPIETMVWNLPVKIYSTLPKQITQHSVGNDAYTMFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH54</accession>
    <name>A0A835GH54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000109">
        <property type="protein sequence ID" value="KAF9415528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH54"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="28898" checksum="1A4BD533F99802C1" modified="2021-09-29" version="1">MASSKSKLIKTYVFFDLETTGLIDIKEDVMPSITELSMVAVDRIHFLNTPPYDVPRVQNRLLLCFNPEKKMSVESVELSRLNNALLETLSPFDKNSCDLIKLFISRLPKPVCLIAHNGLTFHFPILQHFMKLNAVELDADVMCTDSLYAFYDIFGMGHVKQTKTFNELIRLKYYQFEYKVKSEYKPSQPFKLQHIYAREVQWPLYDSSKSQCQTLQVLKIALKKAEKVIEWIDANHCKFSEVIVGENNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH63</accession>
    <name>A0A835GH63_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_005370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000069">
        <property type="protein sequence ID" value="KAF9417540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH63"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9417540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="76" mass="8346" checksum="C30D3D69184FEB82" modified="2021-09-29" version="1">MVVNTADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGEYTTLPYSALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI86</accession>
    <name>A0A835GI86_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_006290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI86"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000032">
        <property type="entry name" value="Blast:SAP domain-containing ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9416336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="269" mass="29576" checksum="E49279FC580EAC42" modified="2021-09-29" version="1">MADSTVTDVTKMKVVDLRKELKSRGLPYTGDKAELVARLQAAMSQDEHGDINLDSDEIDSDGVLEDEDDKSQGDILDDNAVDTLNEELALSEQPSPVKPTVEPKPPRTLKRRITSTEVSKDKTEDNKTTEENKESAAKKIVLNRAISITSAPAKPAEDKDVAAAETNPASNKIKITADLDAKTRMEMRAKRFGLPVKISDDERKEARKQRFGQTVSAKSTAISNTGTSVNLEKFKKRAERFGQSVSKIMTDIENQEKLAKRKAKFGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIY1</accession>
    <name>A0A835GIY1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000044">
        <property type="protein sequence ID" value="KAF9419325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIY1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="322" mass="36268" checksum="3EE11BCA5B37FBAA" modified="2021-09-29" version="1">MKNSGVFIKWATIYRVGGDLSSHTSRVAAVATTATAMIRTVALLCLLAPAFIDVSDAFEVGFRRRFGLNPFDSVFINSPRTNTSAEDQDWVNVERPYSAEGYEALQMWCPADDYVFCILTDETGNTAGTQVSVRVDTFTAAYDMEELGFKNWSADVNGVTIEYYTKAQYFVPADAAARSAYTDPDKALIRNDYVTVEGFKDQMVKVAKYESDLDSVFTKQACILWMGRHYYYDMTEELECSSNSIFTWFPLYIDGELNGMGFMVLGTVTLPEGVKDNYEHPTKGDVQKIVTSGPECLYEDVEKNGVTTMHIYFTEHPRRIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ75</accession>
    <name>A0A835GJ75_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_005039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ75"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9418055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="317" mass="35197" checksum="2D35064F581DE089" modified="2021-09-29" version="1">MSINLDEPKFDQKTYWGRAKHFILLTNPLNAFASDKSLNEAKRVVDEFRKTKRMPQGYDEEKLWAAKYLYDSAFHPDTGEKMVRFGRMSAQAPMNTIVTGCMITFYKTKPAIIFWQWFNQTFNAVVNYTNRSGDAVITTKQLMASYCAACGGALSTALYLNSKVKGMNPLYARLVPFAAVCGANFINIPMMRSNEIMNGTPVFTPDGQRVGESKIAAITGILLVCISRVGMALPGMTLVPVLTQTAIKKKIFHPSSLAIVPFQLSLVCLCVTFATPLCCAFFEQKANISINTIEANLKDKALKLSPKTDTVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ81</accession>
    <name>A0A835GJ81_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_004664</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43457"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ81"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016937">
        <property type="term" value="F:short-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF26">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="256"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9418515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="406" mass="44550" checksum="EC57941AD5EDC73C" modified="2021-09-29" version="1">MATRSLLKTTKLGVYSRQCLKALGQQRAFTTKLTEQQQCVQEMARNFAEQHLKPNAAKHDKEGLFPFEPIRQLTEMGLMGACVSEEYGGMGMDYLSLAIAVEELSRGCASTGMILSIHNFLYLNLVNEKGTPEQKEMFLKDFTRNSIGCFALSEPGAGTDVAGIKTRATKDGDYWILNGKKNWVTSALEGKALVTFATIDPELRHKGIACFLVPVETEGIFRGQKERIMSVRAATACSVTLEDIRVPKSYMVGQPGEGFRIAMEQLDQARIGIAAHAVGIAQSALDTAISYAKQRVAFGKPLTRLPSVKDRLTEMCMLVETARLATYRAAVDVSTKNSAMAKYLAGRNAAAVADHCVQILGGRGLSVNYDAERHYRDARGTQIYGGVTDIQKRLVGHFLLKEHDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJF7</accession>
    <name>A0A835GJF7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HF086_017530</name>
        <name evidence="7" type="ORF">HW555_003844</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000040">
        <property type="protein sequence ID" value="KAF9419725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000593">
        <property type="protein sequence ID" value="KAH9634747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJF7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9419725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9634747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="138" mass="15832" checksum="FDBA1D8B85494EBA" modified="2021-09-29" version="1">MLQLPTIQTPPLFGDDTLLRSIDWLEGFPWKQENVVKRGVDKYEICIKVHDYAPEEISVKTADGFIVVEGKHEEKQDDYGYIARQFIRRFQVPEGCRIEEIKSRLTADGLLIISVPRVPIVKKDTVIPVKHEGSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJT1</accession>
    <name>A0A835GJT1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_015279</name>
        <name evidence="9" type="ORF">HW555_004658</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000054">
        <property type="protein sequence ID" value="KAF9418509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000730">
        <property type="protein sequence ID" value="KAH9632075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJT1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9418509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9632075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="251" mass="28759" checksum="30E39F887317F0DE" modified="2021-09-29" version="1">MAELLLDPKIRLWVFLPIVIITFLVGIVRHYVSIILSSQKKIELLQVQDSQVMIRARLLRENGKYIPRQSFAMRRHWFNNEETGYFKVQKRAAASQNPMTDPGMMTDMLKGNVTNVLPMIVIGGWINWMFSGFLTTKVPFPLTLRFKPMLQRGVELAYLDASWVSSASWYFLNVFGLRTIYALVLGENNAADQSKIMQEQMSGAAMAMPQDPKAAFKAEWEALEITEHRWAVANAELDVLSILDDHQHEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK59</accession>
    <name>A0A835GK59_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neurobeachin alpha-solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000070">
        <property type="protein sequence ID" value="KAF9417495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK59"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurobeachin alpha-solenoid region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="97" mass="11212" checksum="354AF2EB855C336B" modified="2021-09-29" version="1">MQLVGGEFDMELNFVIQDAQNIQHMLELLDHCPPSLQAEIWSVFIAILRKSVRNLQACTDVGLIHHVLQRLPRAETVVAELDSELLCKWLFRIIFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKA2</accession>
    <name>A0A835GKA2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000049">
        <property type="protein sequence ID" value="KAF9418873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKA2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="276" mass="31652" checksum="2991C6BDA6367C7B" modified="2021-09-29" version="1">MEAATLQKKKTTISKGKLKKTIKNVICRPDPLFWPEATEDEGNKLVNMLKKHKINQEPFKKPHWKDLKDLPKEQRPKPPKLKKPEGLLLGVRECTESVHNGECSAIIIEAKINPRLIVQPVVEMCTAKGVPYICLNNLRQVSMVNFGVPTSCLGIKCDCLLDIKKEIAEIAKNHPATKFIKQIKQDDIIEEKMDIDQTSNNNEVKVTEVTPFKFLYRTSKSTRVFVPTTTDNTSKTNKKFIGQNFIEFSDKQTDNETYKKMLLKRMTNNPNRVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKL5</accession>
    <name>A0A835GKL5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000062">
        <property type="protein sequence ID" value="KAF9418043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9418043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="141" mass="16138" checksum="D1001114EC159AA6" modified="2021-09-29" version="1">MEPYWNQEMHHDYKIDEYYSYNPYCHNLYHQGYDQYNEVVPPHVLMDTAVKVDGDERESLSASSTTAAKRGTSDKSLCTQFSPEQVEKSSSLCRKTIKTPTTERPERKDKSAKRKPRITLLTNSGPRLGSPLQEPAILDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKU3</accession>
    <name>A0A835GKU3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein grindelwald</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_005263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000067">
        <property type="protein sequence ID" value="KAF9417682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKU3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032309455" description="Protein grindelwald" evidence="3">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9417682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24021" checksum="E56E15FE2356F482" modified="2021-09-29" version="1">MSRLACLLAVAGAASAQLTLDGIRCGQLVCQLEEYCSPDTNRCAPCSVACNKTSHNYDAGLCIKECQGVQRQAQTALIISAVALAILVLVLIIVCRGKFSWRYIKQKFQPAKNRVKQYPNDLTHHNPHAEMPKPKHELKLEIRNPDPAKRPQQPLNVRDLETRTSITEKSQGATTPKTISTALSNRHPAEDTTLDFSYDNMGMNVTPPEQPATSHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL97</accession>
    <name>A0A835GL97_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_004310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000048">
        <property type="protein sequence ID" value="KAF9418983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL97"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032829039" description="Thioredoxin domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9418983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="347" mass="39884" checksum="815C86BF14F82FD3" modified="2021-09-29" version="1">MNFLSAHCFMILAVLSVVTSSRVLELSDKFIDISNEGMWFVKFYAPWCAHCRRIEPIWAHVAQSLYNSPIKVAKVDCTRFMAVATHFKVRAYPTIMFIKGPYRHEYIGERVKEDMVNYALRMSQPAVQRLSQADSLGYLKETHPVFFGYVGKQQGPLWVTRSNINELMDIEKYIVIAIVSENKLNEITQTERDFKDMVESIIKKRKRDLHHRFQFGWMGNPELANSIAMSELTIPHLIVLNSTTGHHHIPEDDPVLMTPEAVSMFLDQIHNQVAPTYGGNSWPVRFYRGFFEARTTLTNMWRGNPVLTALVFGLPLGFLSLICYSVCCADILDAEEEDTPETHEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLU2</accession>
    <name>A0A835GLU2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000043">
        <property type="protein sequence ID" value="KAF9419428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLU2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="362" mass="42342" checksum="F2DC6B7D4003E2EB" modified="2021-09-29" version="1">MDYDDVGRIDKERTLETMAQLIKCLDLVDFTERPYKPRRVPKKVGRIPVKYEEYKPVLVSVKPIRRYWLLSDSNQFTKGVPVQQRVYEDEKDSNIKQKIAMLVEQTMQDAHRKMKLVDELKEEHRDEAPYKAGFILSMVKKSKDVLDELFNVAVKHKDEWMALEQLKIFELIVHTNVDTTNLLRQLVDVHVKHINATRDSKRVAPLSRATDTPHLPHDEVGASALVDDVTVRLRRHSFRKAYEDEKDFNLKSKIRMLVGLAMQDVSKKMEDTEYIKEKFRNHKPYKAGFVLSLIKKSRDVLNELFNVAIKHRAEWKALEQLKIFELIVHTNVDTTNLVKQLVDIHSGHLYIIIVLIKAVMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMA5</accession>
    <name>A0A835GMA5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">snRNA-activating protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMA5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9420515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49504" checksum="BE4AEDE9E625D706" modified="2021-09-29" version="1">MYHQHMGSVYIADGFTDDCDELIHRCLEAGTVTFEIFSEVWKSMQMSCIFRNRSSGAEIAELTEEVIHIAKNYMLADTSNFEESVVGLFLVYSLLNLQPYANFAHLRIVQEDLPAIQRIEVVARRDRRQDVLYILGSVLIQGPVQYQAVLRERGMEYPIRKYLEGYGSMDKKGARPKGVFYRQNTELDLLKELKQLTIRYCNAKENITGVKPDDLNYVDPNFAIDLDTSLRNVISGIYDNDDREVDDVNDADSTTSTELVKSIKKKAMEAKVKPLRHRMDVAARSNQQATEVKKTSNPKTYRNPKNKAKKRVRKEGNNSDDSDYTVKNDSEEDVDNDILDLAAFNQPTTEAVDIQIDSLPEIIQNEDQMQTYEIEIIDHLNQPSPSSASGSPDNATNQEVFKDKRDLKKTILKSRFKRMGMLPVANFDTTREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNM7</accession>
    <name>A0A835GNM7_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_002499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000023">
        <property type="protein sequence ID" value="KAF9421566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNM7"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9421566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="388" mass="44089" checksum="66ED895B59DAEE68" modified="2021-09-29" version="1">MNCKKCYSPSTVILRKKDYYCDNCFMLITNHKFRACLGKNKVLIPYENVMIGLSGGVGSTVLLDLVHHATSLENTKKLRISPFCLHLYDDDSRELAESIIKQCQTYKIDVFVVHQAVYINSKYELPEANTLQKICESERRDFKDLMNSMPPSAANDFLLKIKRILLVEFAKKINCSVVFTAETTNTLAVNLLTNLAIGRGSQVQYDVGFCDNRDDKVKIIRPIKDISIEELNYYVSIKQLTPVNYNHIKSKSLQSVISSFVSELQDNFQATISTVCKTADKIGDQRESINSEKCLICESDLDMKNMKMSAFEATNVSRIVSLKDSQADPTYQETSDILHHMQNNTNTSVFPLINKYLCYGCSRNHSEMNLHKLPNQLQKALRTNNLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP03</accession>
    <name>A0A835GP03_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_001901</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP03"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000153">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF274">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="382"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="728"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="665"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9422311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="942" mass="104652" checksum="45784B0DB9FA585A" modified="2021-09-29" version="1">MLPPSEGELAAPASVVSRMHRLRNLRKGTRVIKEKRSDLSSSKATCAQPNLSNTLLKTRGRRHWQYDILVNVGLEWGLRKKGVLKAVRELDGNERESCEALLKDVSMYARVVILSVRGSLVREFLLAAHTLGMTRGDWAFLDVEIFQGGYWGETGWAADDERDTAARAAYEALLRVSLKLPTGDRFDEFADAVRARAKQHYNYSFSDGEEVNFFIGAFYDGVYLLGMALNETLTEGGDIRDGRNITKRMWGRDFHGITGHVRIDAVGDRDADYAILDLDPVTGKFEVVAFFHGLNSSYKPVAGKAIHWPGGRRGPPPDTPRCGFLWNDPMCQGGKQARIDAELNNTSWRVRPEEVLVEVGTGIGASPALHSINEVLKYPREYRCSIYLGTPSLTLSSFTVGLYKGNRVAVKKIHRKKLDLNKKLLWEIKQARNVSHENTARFIGACVDCPLVFVLTEYCPKGSLKDVLANDELQLDWNFRTSLVHDIVQGMCYLHGGLGAHGKLRSSNCLIDGRFVLKISDYGLNTLCTPTDLIKDDTYYYKLLWTAPELVASSIYPGAAASLKGDVYSFGIILEEIVLRAGPFHNYTNTMSSKEIVSHVCARESPPFRPVVSVGEVGAAAGGGGGAAVELLDLAERCWAEAADDRPSFDTINANYIKGYCDNLMDDLLRRMEQYANNLESLVEEKTEQLSLEKRRSEELLYQVLPRPVAQQLMAGEVVQPESFECVTVYFSDIVGFTELCAASTPMQVVDLLNDLYSTFDRIIGFYDVYKVETIGDAYMVVSGLPERNGDLHAREICLMALAIVEAVRGFVVRIGVHSGPVCAGVVGVKMPHYCLFGDTVNTASRMESTGQPLRIHLSENTRALLDQWGTFVVERRGEVELKGRGRMLTHWLLHCSEPEARPPTQGLQPPPQYPILFPTLPQPALSLQVPYLVVEPPTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPC9</accession>
    <name>A0A835GPC9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GPC9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="250" mass="28970" checksum="A16440B5DDD250EA" modified="2021-09-29" version="1">MEKSLTSITMLPVIEINVCLELKSKLCILCLVLTSHTLLACWSTGKYYDWQTTSVKGPIRDGTYFETKLNPSYRYLPYKQRYLHMGLHGFDLFPQVARNWTDWYTKESKRQKEVSYINERNKKKVLADRGADWPTLPGWADLGEGLDGSPVPPWAYTVKHMGLPQACMQPIQSFGFCLDTSLNNKEKIGYGYNPYYGICFRYITNECHFNLNFFATLEQCEAYCVESPPNSNCNKDTNIPIDYTYIYDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQN3</accession>
    <name>A0A835GQN3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_001977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000017">
        <property type="protein sequence ID" value="KAF9422387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQN3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="8508" checksum="8CFDAA0F3BD098E8" modified="2021-09-29" version="1" fragment="single">FVACAGAARTISLARESRDFGHRDVIPGRDEPFTTKNRRPSSSHTGATELSLSITYTWGRCASAGSHLGEIDDDDGVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GQZ2</accession>
    <name>A0A835GQZ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HW555_001824</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BAW_Kor-Di-RS1</strain>
            <tissue evidence="15">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="JACKWZ010000015">
        <property type="protein sequence ID" value="KAF9422620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GQZ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="302"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF9422620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="512" mass="55467" checksum="BDD277409B44557A" modified="2021-09-29" version="1">MFLLKGSRIITIKMRPTNKLFKAMAAYSSKVSLNDVVIASAVRTPMGSFRGSLASLSASELGAVAVKAAVERAGVPKEEIKEVYMGNVCSASMGQAPARQAVIFAGLPKSTICTTVNKVCASGMKSIMLATQGLQIGSQDVILAGGMESMSNVPFYMKRGDTPYGGIQLIDGIVFDGLTDVYNKFHMGNCAENTAKKLKISRQQQDEYAISSYKRSAAAYEAKAFAEELVSVPVPQKRGAPPVMFAEDEEYKKINFEKFTKLSTVFQKENGTVTAGNASTLNDGAAAMVLMTAEAAQRLNIKPIARVVGYADGECDPIDFPIAPAVAIPKLLEKTGVKKDDVAMWEINEAFSVVAVANQKLLELDPAKVNIHGGAVSLGHPIGMSGARIVVHLCHALKKGEKGVASICNGGGGASSIMIEKLAHTSDGPPVLTFYTKDPCGLCDIVMEELEPYKNRIIIQKVDITEKENVRWLRLYRHDIPVLFLNGQFLCMHKLNKHLLEKRLQMIEEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRB8</accession>
    <name>A0A835GRB8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_000832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000005">
        <property type="protein sequence ID" value="KAF9424123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRB8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033003923" description="Cathepsin propeptide inhibitor domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9424123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="107" mass="12569" checksum="A59F3483D4C18D78" modified="2021-09-29" version="1">MRSVSVVLILVVAAMSSAGPADYPPKKEHYDLTKADELFEKFIKDFEREYKDEDDKQLHFEAFVESLKKINKLNKENPTTTFGINQFADYTEQERQNMFGLRYVPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRJ0</accession>
    <name>A0A835GRJ0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-piRNA 3'-exonuclease trimmer-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000021">
        <property type="protein sequence ID" value="KAF9421898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRJ0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="60148" checksum="CB14CCDE75938A11" modified="2021-09-29" version="1">MEITSRNFDDEFENIKRDINNACFVAFDAEFNAILSGDNFKNRLFDTNEDRYNLIKKEAGQLIMTQVGLTIFEYQKDRDTYMAKSYTFYLCPQSFADIDQCFIFQASTLKFLRTHHFDFNKFIYGGVPYLSKVEEAVVRKNLKEDILFNQLTRTLQMEDEKQLQHYCSEVSKWLIRSNEETMYLDVNSHILRYITHMEIRMRFPNVLTTDSLGDGQKILIYRNKNVEGAISTPREELENNLLSGLLGFSKIITLLAESQKPIVGHNLFIDTLLLHNQFIGPLPNKYKDFKKNIHAMFPIIYDTKYLSHEMAKKLPYNECWKSNALQDLYEFFAERKFKKLQMWVNTIQLSRPFAANQTYHEAGWDSYCTGFCFVRLGHWVACENRGSFVNVGPREMLKVLTPYCNKNFAEDDPPRFRPQLLHLMLLNQGSINVTQVASELGTFGSIDIKPYGNKAALVATSSQNVALKILKEFRNSKEYKITPYSIYRHSPAKSVVLWSSALITGSIVLYLLHKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRP0</accession>
    <name>A0A835GRP0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aldose 1-epimerase</fullName>
            <ecNumber evidence="13">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_000494</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="13"/>
    <dbReference type="EMBL" id="JACKWZ010000003">
        <property type="protein sequence ID" value="KAF9424355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRP0"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000003">
        <property type="entry name" value="Aldose 1-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008277">
        <property type="entry name" value="PRK11055.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9424355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="367" mass="40389" checksum="394339122B1F5BC0" modified="2021-09-29" version="1">MYAMLTIETEDFGVHKGKTVKKITWRISGGAEVSVISYGAIVQSLKVPDKFGVKKDIVLGFDDLESYVKRNTPYLGATIGRCANRIGKASFEIDGKTYNVAQNIGKDHLHGGIVGFDKVVWETTLLGNKVVFSYYSKDLEEGYPGDLITSVTYEVTDDNKLKVEFKATTTKKTVVNLTNHSYFNLAGHDAGAQELYNHKVIINADKITETDSNSIPTGAFKMVKDTPFDFSLSKKLGDAMSAGQNLFDDNYCVISYGPSILTFVAAVSHPSTGRFLEVYSNQPGVQFYTANFLPSPSEPALVGKSGAGYRRHGAFCLETQTYPDAVHHSNFPTSILIPGDEYNHRVVYSFGFLNEDKDFEAPTVTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GRZ2</accession>
    <name>A0A835GRZ2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 33B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000002">
        <property type="protein sequence ID" value="KAF9424541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GRZ2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72374" checksum="A8D08EE18BB3FEEF" modified="2021-09-29" version="1">MDHQPLALKLASLSLISQRKLKEILLLCGDKKDLIIDPTLIKPLERICGVSWLRQHGIDKIYKMDPQLGSTANTNRVYFIPACILKYKCVLDQISSVLSQNPALANLNCFHIIIVPKVLTTYDSVLESKGLYGIVKLHTFSWELMALDEQLLSLELPFLFKQLFVEQNHSLLSSISMSLWSMFHVTGKPKTIFSVGKLSANVLDMLEIYNETYARDFLDTHSSKEIGALIVIDRNQDYASSLLTPATYSGLLSELFNINCGHLDLNVKETKLKKGKLNFGAEEEAATSKNTVMTLDSSIDTLYGEIKHRHFSEVLSVLSSKAKLLKNEDIKALGIQEIKQFVATKLQQVSLFKQNLVNHVLACETIISEMSNKFENLKLTETEMLNNRNKKSNFTFVDENFGTDIHIYNSLRLMCLLSLTQSLTYDEYNALISKYLLAFGYKYLYVFNNLINAGLLVQPSSPKLSLNISNLGNLSDRLPKWQNEFQSTANKLKQLPSQADKVGKACPSYVFHGGYVPLIAVLCNALLTSDTFADALAKLSAVSDLKVGGTILEKFKDGIETLNEKLSNLKLQRDLEFGCKDVRSLAKVLKSEPNKGGCFPLKPKTVLVYVVGGVNYAEVAACDVIQTNTGSKIIVASDCISSGADLMAANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-10-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GSF6</accession>
    <name>A0A835GSF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000001">
        <property type="protein sequence ID" value="KAF9424895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GSF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043517">
        <property type="term" value="P:positive regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042450">
        <property type="entry name" value="EEF1E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44490">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44490:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9424895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="172" mass="19247" checksum="EEECBAFE4EA934AD" modified="2021-09-29" version="1">MSACNVEVIKQVGRYYNVSVGTVCFNTDKVLTTVINKQSIEGFATIVLKLASLSGLQLSQEERLLSYQWLEHIAMYANQAAANPVFALGFLKDINKALEKTTYLTGQKLNVTDVAAYYVLYPLIERLSVSERESFMHVCRWIKHIQAQPKICTSQPVPLNTLNLTILAPAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT00</accession>
    <name>A0A835GT00_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HF086_002706</name>
        <name evidence="16" type="ORF">HW555_000883</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BAW_Kor-Di-RS1</strain>
            <tissue evidence="16">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000678">
        <property type="protein sequence ID" value="KAH9632884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT00"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="74"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF9423825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9632884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="153" mass="17257" checksum="1C0508BD43942820" modified="2021-09-29" version="1">MAAATIARSALKGLLRSSTTVRTPVVCRLSTVALQQKFRSINAALKTYNTQYHQNGVQRTQQYTTGGHHKPSPQEIEERVLKVCKAYDKLSCVKLSVDCHFINDLGLDSLDHVEVIMAMEDEFGFEIPDGDAERLVRPKDIIQYIADKEDIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GT79</accession>
    <name>A0A835GT79_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_001004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000007">
        <property type="protein sequence ID" value="KAF9423678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GT79"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="792"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9423678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133296" checksum="3E7211BEE526160E" modified="2021-09-29" version="1">MAIGVDTSKWKPRKIAGTPASKFRNILGVGILSFGIITGLIFHECIRSKYFVPKPDMDESLSDFQEAKQSCKGPKPVTKPSKPKTRKVTKRIKGQKDIRTALKGKKNELEAYTKEFDNVCKKSGLDVDSEQLQLAIALSKSLQTEANEPENTSTLTSQQRVANIRKTLQEYGFKVPEAKITAVKKARKLKKNYKLLTTPEEEKHQIITSKYTQVLFENLDKSIIEQNSEDLNARVFHIASNILYECMKDDSIFYVDNLVERSKSNGSLLRDWSEIPGRPVSPKPEAPTTMDFKDIDCSQNELDVILSGSIKSVKDILDTKYSKLKNNAPCIIINDEDKCNNKMDSSIISIDDNHEVETINKSPFEKAFCLQSPIKKVGPKTPVKRLFNDESCVSDVIEITSPKVENKDCKVLNIESKLKVTEPCRSVSPDIFDDELSSIIDVSKPINILSQEHKTKVFSQDNYMDLTQCANVVSQNSEKSALLSQDVTKRKSNDFMEITECVVGSSQPIREELKEIDLTQSPEANNTIRGGNNSINVDNNLDKVSVNISNDVEQETSDSVSQNITDEQNVTVVPNERINMDKEDNVDLTQSSNEQDGNMEVIDDNNEARGKNAGESINLTQSSNSDDLDGLPSVNFGDSHAQTYLDDTIIVDPVDYISNGKVKQSTLLGNRAQSPVCDLTQEQEAKSNSSPVLAKEACTSFYEDFVHEHSESDISKEIEQNVRKKDDSNNVLREEETDDIDLTQSSDTTEEISNHIESDKNIFNNSSLGKNGDISIDYDEIDTEDNSYNTESLKDNEKNDSMTQKSEDNNIHIIDENDEALNSSQNSEVFHISDKELDYSLHKSRFELPKDNFDFGGISVLDNITRLDGTRNLSEIGQRISVANENVVDSLPEIKFGNENEKGIDKSEVHVNMDITSEEFQDVLANTNGVINVKTPNKSEYVIKTGDVTPMADYASMSTPERNRELDKYGLKPFKRKRAIKILTHIYNQMHPTIQQLVDEDQPSCKKPRLTLTQDSSPKKFAKSPTKSSQIIPKKSPLKIHNGIAHCSHTNSDEIERDRCIQSAPTSKVDEKSSEVCAYEVSNEFAIVKTIECNPDDWVFQKREKAKVHSCRVPLHIAFHNYVLSRRSLREAILKYEPVNIDVIHKDLVGYGHRYDPKELLKFLDKRCITVKTTDNNARNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GTU7</accession>
    <name>A0A835GTU7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_000916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000006">
        <property type="protein sequence ID" value="KAF9423858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GTU7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032577505" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9423858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="104" mass="11878" checksum="013510D0E6DE0906" modified="2021-09-29" version="1">MAFKLFTLFTLCVILHMVFSLPIGVENKSPVSAQDEALDLSKSVAPSEHLYVKLSVVDHSKMDVLKRIKRNVIGDEKCPEGQRLFMNECVTQEKYDEMMGEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KW39</accession>
    <name>A0A835KW39_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_014362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010001000">
        <property type="protein sequence ID" value="KAF9404381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KW39"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="514"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9404381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="703" mass="80498" checksum="F08E57AF71A33E28" modified="2021-09-29" version="1" fragment="single">ISNLPSLKNLIIKDCFAELPKDLITECEALITLDLSQNRITGIPEGFFKDLKNLEHLDLSFNKISTLKSGVFSPVKKLKYLNLDRNHLEVLPEFLFAGLRKLTEVSINHNLLTTIDALAFQGATSLQTISLIGNRLTLKSKDQLDWDYMDMGMYSPFNTLSELKKLDLSHNNISKIFDDWRFVLVNLEILDLSWNRFEELYPNSCQFLSNKITVNLQHNDISSVNLYQPAAQSDTTAPVAEPNSSILLDNNPLNCDCRMYNLAMRLQGLKPTTTEPKFNVGNAQCKSPPHLQGDLFKNLSPYDLYCEEMTEEVRFNCTSVLIRPAYRDLYYDCDFAPPFFPNTEQYGVEQLSLKLQYPPNDLSNLTLSLLNLTNIGLQEIPFSPSESVKEIDLSKNNLTEIPIRFIESNTSLYLSSNPFDCSCFARDSVIALRGSSNIKDLDTVSCANGLSISELEISTLCHSNTLIIAEIGGIFLFLLILFTLAFIFSRQIVDHFGHRIFPCCFIDDPDNSPKEYDVFISYAHKDQKYVNKLLPKLENDFKLTVCVHYRDWEVGDFIPDQINRSVLNSRKTIILLSNSFLDSTFANLEFRTAHNLALKEGRERVILIILEDVSKHEKLSEELKYHMKMNTYLNWDDSRFDEKLRRRTIPQLYNKKKFVRPAILKPIFKQATENNLKKALDVHLNSAGQLVNLAQNKKDIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY22</accession>
    <name>A0A835KY22_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000433">
        <property type="protein sequence ID" value="KAF9407811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY22"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033551">
        <property type="entry name" value="DRC7/lobo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249:SF2">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9407811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="22359" checksum="9AC3FD827E983E4B" modified="2021-09-29" version="1" fragment="single">MCAAPTVKLAADHRSSEQNKTTEQESSSQQPLDTVEEVNENVPSEIFERPFEQEDFVEIPAKIFGLKEVSEPLTIPGLNNAIYELGVVNMCWPEITEPVFENRTCFPPSYYTNSPKERLLLAYAENFRRQYNFHYKMRKPILLQVPNECGLQKMVCTSIRPTKLNFDETNSWQGIASLVSDYFDYEPLTKPTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KY56</accession>
    <name>A0A835KY56_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_013430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACKWZ010000645">
        <property type="protein sequence ID" value="KAF9406062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KY56"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033095862" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9406062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="553" mass="62721" checksum="C36F39354C4DD0F9" modified="2021-09-29" version="1">MQWRTCVLLLCVTAALADDEWREVETAQGIVRGRKHPTEDIYTFYNIPYATAPVGVDKFKAPLPPPIWSEPYDAINQQVVCPQSILMPISHLQPVQQENCLIANVFVPNTDEKNLSVVVYVHGGAFVMGWGDIYEATQLMNKKDIIIVNFNYRLSVHGFLCLGTEDAPGNAGMKDQVALLRWVQKNIASFGGNPDDVTILGYSAGSASVDLLMLSKSAEGLFHRVVPESGGNLAAFSIQRDPVEIAKKFARQLNFTNVDDIYALEEFYKTAPLELLMSDPFFDKTDSTFMFGPCVERNIGEETFLIESPLTTLKNGNFKKLPVLYGFAEMEGLFRIDFFPFWKQMMNDKFSDFLPADLKFKSEGEREHVANKIKRFYFGNGPVSEDNILQYVNFFTDVIFAYPMLWATKLHVEAGNNQVYLYEYSFVDEDVPVVPHTNIRGANHCAQSFAVLDGKNLTHLSHTDESLATPEYQEMKKTIREIWYNFIKTGKPVPEGSSLPAWPAAGADRSPHMSLGQKIELRGVLLEERTRFWDDIYQRYYREPVPPPAPQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZD4</accession>
    <name>A0A835KZD4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000760">
        <property type="protein sequence ID" value="KAF9405324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZD4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="131"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9405324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="411" mass="46408" checksum="2F7773B38A25DF45" modified="2021-09-29" version="1" fragment="single">PCTYLPEQVLPPLFDEQPAVLPSVIAETTFDQPGMHESVSTLRLSHDSSHSQIHRSQLPSAWSFEMRPLQREVFSGYDNGKRQSQCFGENSDLWTIFRSLVNAEMIELMVTQTNIYAAQLQRLSNLKPKSRIKQNSRKIFTPGDTVVVDESMVGFRGRVQIRIYNPQKSSKYGIKIYKMCTDIHGAGYTWSYKVYSGEDRAVEGLDKPGSVVVALAADLLNEGRLLVTDNYYSSVPLTRYLKERRTDFCGTVHVVNANLRKGEIAAKQNNFLTVLKWRDQRDVLVMSTCHNPGDCDIQMLKPKIVLEYNRGKKGIDVAEQLASYNSPIRKTCFWYKKIAGDLMSICVINSILIYKDLNLNSKMDVLKGHEIIIKRLLNLQTPTPSADLPTPRSSRSSVSIEQPGTSGLSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZL5</accession>
    <name>A0A835KZL5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 251</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_011852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000379">
        <property type="protein sequence ID" value="KAF9408495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZL5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF13">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1045" mass="119401" checksum="B94A16439E9A6AC5" modified="2021-09-29" version="1">MSQPHFPRSSNSMPRLSSSVPRLPNSMAKMSFSDNDAGDMFKQYHSLSQHFFDKFQGQTGSTPIIQKPAPFKMRWINGFNHRVGVINLNDKGSTILFYSASNCGVIYNWSTHHMWLLQGHRHMITCIAADDNGRWLVTADSGSENVLIIWDVKDLFPQKTFFSPHGSAKIAKVALSGDAKYLLSLAYSAEKTSLYFWIWSHGQDFPHAIYETTTIPRDSIIVMGFNPSKSEQFLMMTRTNILIGVSKKVVVVERGISRETNRWEIIVKSMDAVNPEYGKLMCYTFVKGTSQILLGTTRGAVLVYGYTIEYKANLEPMNIDNLRYIKMLKLNKKLIHVIKNIDGVIVTGNSCGEIHFYDEQLKLLYWVHGFTVDRVKALSFNISPRSSIILDPKCNKICPCWEKVEVDKDPDTGEVKQKLIKMRLPSDATVDGKPFLVRDFIITTYNQGVGFVDFVTEKYTTILDHNRSLIMTISVHPEKSLICLGYKNGRVELFDFCRHKLIKRLNLRHTFTVVIPPNEDSINCNFAITVPELSVTCLKYSPSGLHLACGLNTGQLLFLDPSTIDIRTPTPFSDTKSDIMFICFSQDSITLATADAFRTVCVYKYNCETFKWVFIGKHRSHYRDITALVFVPSNTNGGEYKLLSFGLDRSMVEYDIANSKQEYLEIASLDRVEQSGVPLAAIPWPTPAELNPEEYRTDLPMILMANDEFKYKIVNYATTMTLSTVLGPRYDHPVSKMQLVSHKKGEETKKYLLFSCREVIGLQKLPLDGNPWKHVGLLGHPIKITEMCFREDLGILFTIGAKDTTFTQWLAHFKSVETTTKCGGSDLDPYYCLVEDGRPGWLFQEIRDLFYYIQILCQGTFSPARRQVKDYIPIDSLPDLMRALGFFPSEYEVENLLIEAKYKVYLHTPVTEIDFEEFVKLYLNHRPVFGEDFKRLRLAFRTFANIGKDGFSIKRNDFIEILTTNGEYFSRELCWYLLTILAGHSIEDRALISEDDFSFLPEKINFSDFLTEIIGIQEMENVSDSYSGMESMISIHTITSYESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835KZW6</accession>
    <name>A0A835KZW6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_013341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000625">
        <property type="protein sequence ID" value="KAF9406222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835KZW6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9406222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="268" mass="30927" checksum="36CC1601479FB8D4" modified="2021-09-29" version="1">MSISWSNEETFKFIDLYQSEPAIWDPNNALHKDKNKVNDAWNRIADSLQIPVSELKKKKETLMSAFRMHLKKNKIRSDLVWEKKKFISQFGDARSNTETKDMNIKIPVQRRRSVKPPELEKADKEMSKAFNTLNQAILNKDQQNKKEDDCDLYGRLLANKLRKYSDNERQDIMYDIDGLLLKRRRNTSPQYVSSPSQIIISKRPSSSATSYSCPSPSSPWINHPSSLTSSNHSYIITSPIQSPSPIPPAQTPSLFHLLNSLMPYTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L042</accession>
    <name>A0A835L042_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_013081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000572">
        <property type="protein sequence ID" value="KAF9406595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L042"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9406595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="288" mass="34097" checksum="68F6F43B824B4943" modified="2021-09-29" version="1" fragment="single">CNRLLRWCPSPDCSNAIKVAYVEAAPVTCRCGHTFCFACGENWHDPVRCCLLKKWIKKCDDDSETSNWIAANTKECPKCNVTIEKDGGCNHMVCKNQNCKADFCWVCLGPWEPHGSSWYNCNRYDEDEAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFESKLYASVKEKMEEMQQHNMSWIEVQFLKKAVDILCQCRQTLMYTYVFAYYLRKNNQSVIFEDNQRDLESATETLSEYLERDITSENLADIKQKVQDKYRYCDSRRKVLLEHVHEGYEKDCWDYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L0M1</accession>
    <name>A0A835L0M1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_009589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000217">
        <property type="protein sequence ID" value="KAF9411672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L0M1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="15734" checksum="70BC0737745F6FF8" modified="2021-09-29" version="1">MASIDKYINVKYKLKSSDQFEEYLKFIGVGMISRKAACAVSPVAVLTKDGDTYTFTMTTSFRTITFSFKLNEEFTEERADGVKTKSLMVAEGDTLIQTQSEDNGRKSTHVRTFTPELLTVVSTADGWDGKCVRIYEVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L108</accession>
    <name>A0A835L108_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab GTPase-activating protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_009171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000194">
        <property type="protein sequence ID" value="KAF9412280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L108"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01211">
        <property type="entry name" value="PTB_Rab6GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="414"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="657"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9412280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96583" checksum="BA94FD4E38FBC142" modified="2021-09-29" version="1">MATIIESCRLVGGSKFYEMMDSATSADVSTPSPTEKHDHMKPTESDDEDVDQECTRFSGVSYLGAQNISDPKSESDIQRIMKELSSMPESRDGIAVSISIPVCSQGLVVLYQADSNNVMTRYAVNRISFYARGAAGSPVASCFAFTWSHGETKESAVYRCHVFRCHIAEAVNQVSMDSTCIAGTFSHVPKERLGFKLRGGIDKQVTINVKQVTNNVQPESDDPQSTYTGGLYIERCFGILLAPGRSVKHSDMRLLEMVSGSSGGSGCSVCALWNAGESALAAFNVASGDGAPAYMSLALDLVIRGIPDPLRLVIETPVKIFPPTERFWYYSKRPLVQQFYINLKESVDALGQLQYEVASIETSDELDRSRLNLPLSLSSLLPSPLSSAPAPPSPSEPDSDGDEPLLSGTGEVSKDCGEDVLVNWAQDCPFEAVIQRDIARTFPAHDFFREAGGLGQDSLLRMARAYAVYDHEVGYCQGLSFLAATLLLHMPEEQAFCLLVRLMYGYGLRELYKDGFEALYMRLHQLDRLMEEQLTDLRAHFQELGVEPHMFASQWFLTVFTARFPLPLVYHILDVFLLQGIDTLFQVALALLSRSRKDLLQHDFEGVLKYFRVTLPKKCRAEESSRQIVKLACSIKVKRLPKYQQEYEKFIKESAEKEKINVELERLKVINTQLLQEKELLEAQLTEVQDQKGDDKEGSSETEARLRQRVRDLELELAQVKLAHVQAQCSNQELSHQLTVALNEVQAAVNQKQTVAPWLVRTLNSIMEAAQTRPSFQTYLPNSNSEQPATPLHRQGSFSSGQSHSHGNLDRRVSEPYSPDVVRRKKDLNASKRHSLLVESNLAKEAKEINRRSHDVTIVKNLSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L1W9</accession>
    <name>A0A835L1W9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_014029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000819">
        <property type="protein sequence ID" value="KAF9405072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L1W9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="907"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="255"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="369"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="7">
        <location>
            <begin position="443"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9405072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1272" mass="137292" checksum="EAF9A2F8AD23FDFA" modified="2021-09-29" version="1">MGYVQSPVLVVELNLDRIEGTQLRALGLLAVYGFNVTYEVRAAAQAPGPTSCSAIECRLLGHCYARQDYQVFYCSCFDGYSGADCGVGPLCPTTSNMCKNGGTCRQMGPAAVSCVCAPGYTGDLCEAQVAPPECGIEECAEVCKDGTACDCNPKDTDALSARFETRLQVVGLPSENISDEIAKQLTQFLKASNITLEDDVQVLNTSLTTTEGIRDAWVRVWSSRREAPALRAALARLASARTRLLPTSTHFEMHPALSLHIVILFNLQKLVVNQRPEVWEGSEFILTCMAYGSPNMAFTWYKDSVKINFNGTTRDIWTRTVSEDALGRRMSVLGVTEAERLDSGKWSCAADDAGRRRCRALRLTVLRPPEIRLVPSTLTVNRGDNVTITCLAGAGRVHGALGFSWARERTLLPMAPGREVWEDLFPAGSVLKLYNVQKSSEFRCQVSSVAGTNAKAVTMWALGSGDAACESDACHGLRWPKTAPGAHATASCPPGHSGETTRFCEPKTGDHGVKWRLPDFSGCVADSLKDIYEQFTLISMGYSWGSVSHVSRQYGAVLRSLPTHPGEGEPPLTHAVHMLNYLMSPAAQPHDRYNSLRSSFNKRYHEFTVMSKPVLEDNAAHFDLQPALAEREEWAVTSAGVELVTKTENASVVTALYHDLGARLPSLKRFVEYKSGRATQYTIASQQIQLSVSGAGVDNTLLHTVTLLFTHSKNYSAIGPQLACGSRSRSSPRVWSTHTCELRVQEQTYIACRCRGLATIALFTVDSLGLTDAESDSRAIVKITVSLGSAMCLVAALLQLLSLVVGSKTRLPVLLRAATAATHSAAMLTLLECDTKQTSACVGPLGWAVAACWCAGCAALCAQPLLLHTELAATATRAPSVGLLAGVSTLCWLTARLWGGAPLQLGAAANAVCGAGAALLAALTLCLALCAARTLRTVTQKLPPDRREYVRERARVVRHTLVLLFTTTATQIAGVAYAQPGERTILKVVALSVAALANGLAMLICYVICDEECLRAARRLLTLSSNNEWHDSPEGDTSLSLYIRQGREMECRGTVGSLECSSSHVSPANTYWRATPLQSPLHRRGSSGACVADIVRCVEYKQALLPPRNVHTRTLCDLIPIAGGAEPRVSRVCVELGVLPEASQTAVTDPSTFQPSSDTSDISKANCTLCAKSTPDVSATSTAPRPIKSCLKKRSPQLSWSTSLPSINHESDESNSHLQLVDTQSQTPSTHTTFTQTDKVLHKISHDLDFLLNRTPSRVADNCPQQIEEAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L354</accession>
    <name>A0A835L354_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HW555_007985</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BAW_Kor-Di-RS1</strain>
            <tissue evidence="18">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="JACKWZ010000146">
        <property type="protein sequence ID" value="KAF9413955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L354"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF9413955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="234" mass="26744" checksum="B06408D9DC83AD07" modified="2021-09-29" version="1">MHKAYNLSKGLIWFIVPVSMIICNDVMAYVFGFFFGKTPLIKLSPKKTWEGFIGGGVSTVIFGLVMSYMMSQYPYLVCPIEYSESLGRMTMDCEPSLLFRLQEYTPPQFLQPVMKVFGMEKLNIYPFMIHSLCLSTFSSVIGPFGGFFASGFKRAFKIKDFGDVIPGHGGIMDRFDCQFLMATFVNVYITSFIRTATPQKLLQQVYNLKPEQQLQLFYALKESLEHRNILNLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L3C7</accession>
    <name>A0A835L3C7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_007765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L3C7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9414287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="494" mass="57992" checksum="950DF3A054192E78" modified="2021-09-29" version="1">MDITKDEFCRLCADLKLSSELINISIDMEKRENINKMLKRFNITLNLDKNLPNTICLTCTNSLEQAYDFVRSVDLAQKAFDDYVSSDVEKDDGSVHLERQVSAEDTEKIETYTVEDSDISEETIEEDIDKKTTEDQPMKDTSETETVNSKRGRKKLLKMLISSKSIDSWNTYKWLCAYCDSYYFSLSHLRVHSMQYHNICNPFRCFDCRARGSQIDKFVTHVCKHHPNLALLCHICSSAFNTTEELEKHKLKVHNSSKFTHICGATFVTRKELENHINNFYQNVAIRMAPYNDNETFICVICKKILKSRVLLDRHLILHTDRKRTSMCKVCKKRFYTTRELNRHVVIHSDKRPFMCEICGFSFKIKQALQKHVMRHFQIKQFVCDKCGKSFRSKKQLIAHSKVHDDTRPFICVHCNKSFRFRHLILQHIRVHIGEKPYSCDLCPQKFINWSNYNTHSKDVHGVDRCKEKAASNNVTVDLDEKLIKWKNDILELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L466</accession>
    <name>A0A835L466_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HF086_015090</name>
        <name evidence="5" type="ORF">HW555_008725</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000175">
        <property type="protein sequence ID" value="KAF9412879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000259">
        <property type="protein sequence ID" value="KAH9640994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L466"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9412879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9640994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="124" mass="13366" checksum="9EA991BDC2C3F157" modified="2021-09-29" version="1">MEDQSGSSGPRVSDKRLAQTQAKVDEVVGIMRVNVEKVLERDQKLSELDNRADALQHGAAQFEQQAGKLKRKYWWQNLKMMLIIGAIGAVLLIIIIVWATSGSGGGSSPAPAPPAVTETPNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L491</accession>
    <name>A0A835L491_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_008675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000173">
        <property type="protein sequence ID" value="KAF9412978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L491"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9412978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="112" mass="13051" checksum="E358A701D631D36C" modified="2021-09-29" version="1">MRWTAKSPGDTYQADWKRTASAHAQTTTSRPVGRVNFIFYLDIVPTVTHVDKYSWYIILTRSVTAGCPVVTGRQKVCIYLNLFYKQEILRRADKQRKKRQKGVHQSSPFEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5E6</accession>
    <name>A0A835L5E6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000094">
        <property type="protein sequence ID" value="KAF9416219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5E6"/>
    <dbReference type="OrthoDB" id="7399486at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032571096" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="87" mass="9651" checksum="6FA6615F08A6F381" modified="2021-09-29" version="1">MNKLLIVLLAVCLVSVHAFVKRDAPAADNKNYIETIQKQMEEFAKTVNTQMAQAFDPDTIKKNFNELVDNASKTINQMKAAAQPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5T8</accession>
    <name>A0A835L5T8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_007004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5T8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032640391" evidence="1">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9415341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="288" mass="32467" checksum="CFFB6A7F3FC2378C" modified="2021-09-29" version="1">MEYTQVFCVVLLAIGCQGMSLTDTLDFGPKEMISNETAAAYNHGVDMGIIDPKKYSLESFAHDETHVFKDTYNEYMSMNGSYPLDYQEWLIMNNYGILPDTNESMFQRKISKRSTADNKRAFVNTVKKGDILISGRGTGGLLGHAAIMTSDYWVLEMPGGDGFMSGIRDNNRQIPKDKWFDEHASDWTTVYRCPDNSVARQAAGWADRNYYNPNGGATKTIHVTYKITADFTSKNPSYCSKLVVQAYYYGTGSKSVIYIRDKSNAIIIPTTIPSYFRSPYLLVNKGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5U1</accession>
    <name>A0A835L5U1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057945">
        <property type="entry name" value="TPR_ZSWIM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048370">
        <property type="entry name" value="ZSWIM4-8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25572">
        <property type="entry name" value="TPR_ZSWIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21055">
        <property type="entry name" value="ZSWIM4-8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1489"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1781" mass="196935" checksum="50EC626726A814A3" modified="2021-09-29" version="1">MVFSNLLTNVNASSAFLRSTPGTFVLQPKWALFGARNDPFTHAREPKTVSNGCMFELTGVSSVGVKDTGVGTSSSLVVPCPVCPYSPVPHVNTPPSNSSLLRGFHLNLTIVAGASSSNGKGGRQAAPVDVGSPLLDWEEADHFSFEDSERFEEDSLCSWSSEPESLCNNWRGWRRPNLQNSFGTRSTKKNIQEKTVSTLSELAAKCVASHIPFELVEHVYPPVPEQLQLQIAFWSFPDSEDDIRLYSCLANGSSDEFQKGEHLFRDRAVKDVLQIGFHLSATVVVLSMPRAQFNVAVTFDRQRISSCNCTCSSTAHWCSHIVAVCLYRIHLPTQVCLRAPVSESLQRLRRDQLQKFAQYLISELPRQVLPTAQRILDELLSAQPNTINTNMRCTRPYRRGFGLRVYILILVKFCVPTPIVFSDVNYLSTSAPPAAAEWSSLLRPLRGREPEGMWNLLSIVREMFKRNDRNAIPLLEIITEEVMACEQIIVWWYTTKAALVAWGNNGGGGKHGGGGGNSAAQHACSSLCDEVVVLWRLAALNPALAPHERDTLHEQFAQWHMKVLDKVAKSRNTHIPASSSSHSRHSSRSHSHSPYINGISENEVFPGFHPAMEACFLEWDDYQIPGVTYTKDLNPLYHSPFTIFRHADKQNESVHQVNSSKAVLNNEMSLSYRLTNPDPSLHGHRTTVLRNSHIAVDLAIPGPSSQPCGSEEGPSEPPRDSGPSDGNHSSVSSEGKYQNKQSGGDTDSQESSSPPISSDDAQRRVSNDESVSDDDCNLYFYDTAAARRAVADEGTSSGTVVKPRRRHTPSPRLCAASHRLSCLASATLAKCAFLCTTLARPVPLGGVQRGPYDPRRPRLRFTFSPRLATHRLLCFTSATLSKCAFLCTVLAEFSEHHELAFRVGLFALEMARPPASTKALEVKLNNQETELVSLLKKLPTGAEQLALAREKAEQLRDGTLRNRGPALLPIALASFLFDVLVLSATDKENKHPARSPNDETLGFEAAVAALGLKANVSEADHPLLCEGTRRQRGELSLTLLSFYKDDPVKLARIMNKLLDREIHQLTKSPMVSLYYMNNPRLAAYRADAAPHPAFAPLPPHAPSALQPQASVNTLRYPTSHRKHLRHFMFELAKSVLFKAGGSSSTSLFTQPSCAREHHGPHRGLHMAAFQLGLYALGLHNCVSANWLSRQAMDIGAPAILFLIDAWEGHLTPPEAASIADKASSGRDVPTVRAAAELALSVLPHAHALNYNEYSAPYCSGGVYPEVLYTVARYWHELYLRQANEETEPLLDEPQYRAQPPPLAVPVPYPIPYPFTYHPYPPTIYQLPYAGTAPPHPPPQYALPPYFVRGIVAPAGAAALAQHPQHQQHAPLQQHAQLSQHAQHPQHAQHAPLQQHAQHAPLQQHPQHQPLQQHQPLQAHQTLQPHQPLQQHQQLQQHPPLQTLPQPLQQHPQPLQQHPQPLQQHPQPMQQHPQPLQQHPQPIPHPQPMQHPQHQPMQHPALGQHPPMPQHVTHATPIPQTITVNATVHQVQHPAPIPPPLPGPQQMVPVAGVSGSGVSVASVSAVGSVAGVGGAAQAGAQPAAPNVNQTQLRRLLAAYRVGMLALETQARRVHDDRPQNKFGRNPPYGEHVKWLLRISKRLGAQYLHQFCVCAVNSVVSPFVLYELCVESAHWLARGGPHHLVMQHLRGTLAPLVQKCQQMYIQCIHQKLYHLTTVEYEEFVSIVLSARTAFQLTPEGNTQFKEWLASLRRSVQIVQERSMDAAERSSANKWQMTSAADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L5W5</accession>
    <name>A0A835L5W5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_010236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000245">
        <property type="protein sequence ID" value="KAF9410811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L5W5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032389102" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9410811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="436" mass="47807" checksum="CFF7556970012941" modified="2021-09-29" version="1">MKTKTLIALCFAMSVCVEVYADGELEVKRGIYPFMAFLYYPDESVTDGSGARFLRGAVLIRPEWLVSSAVGSSILTEEGFPKKTLLARLGAITIDTNFTLNEDEDEQEREVIQIVRPYNHSATQWWRTDISLMKVLLPFNMTSAVGIANPSLKREITEKTCTILVFAKKDGNLSEDRNLMQLTVELLPPSIQDCGSHFVSNTMTCASHSDDNKNALYDPNFCQGNSGGPLICEQEVVGIQTYIDNDCKQPHLYQLLSAWENFISCGTEDKCHTEQCTNICDVTDKDPPPQDAIVPETTTATPSVSLIETTIAPVPVVTSSVPETTIDSESEASSTIIPSAALSEEIITTGHSSSVQEPSPTHSVSETESTETKAWPKAHTDERKKLEEGTLENTDRKPSVEAQQHDGNVRVRSAGQSSAPNIVSLLFGFFNLACLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6B7</accession>
    <name>A0A835L6B7_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000046">
        <property type="protein sequence ID" value="KAF9419148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6B7"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="63" mass="6932" checksum="4B3D3240D1BE03AF" modified="2021-09-29" version="1">MAVVYWHSPGVGFNERLRGASSSTTADLTPRSRGESSPIFVLKFRPASVIKKSQRVVSPEQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6G3</accession>
    <name>A0A835L6G3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_009775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000225">
        <property type="protein sequence ID" value="KAF9411428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6G3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9411428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="22441" checksum="1E58992D0B4F699E" modified="2021-09-29" version="1">MIYLISSVDAHSESIKTEEECKIADLCVHDKVPMCAIDSCGEMRTFIDICDMHEFNCDSKKDFKQRPIHECWVTCKRGRSFKRAEMFLKIFVYCIVVLCIVDYVSGHVDSAKLEEECKIADICRHDQVPICGIDSCGEMRTFIDTCDMHEFNCDSKKDFIQKPAHECWVTCKRGRSFKRPQFNPDCIVAKKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L6N3</accession>
    <name>A0A835L6N3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000041">
        <property type="protein sequence ID" value="KAF9419650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L6N3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9419650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="372" mass="42814" checksum="A6F44096FB62B0E0" modified="2021-09-29" version="1">MFCLGCNQVIDMKNGFLQCKQCRNYYHYECLNIGHEQYSALSAQYRATWQCPSCNNITRRTRSNLNTPVRQAQVPTSDESMNMSFDSSPPPTHATVPSTKSNIVTMDNIRDLLDQRLNASMSTLMDKFRSILKEEVKKLVKTEIDSVVQQLKNEFTMTTDYICADVADLKSEMKNIRACVKTLEAENTRLLKEINSLNSRLSSSEKLTRSLNLEIQAVPERKNENILAMFKSLCKSVNTEIKDDQIISCRRVAKLDPKKDRPRNILITLSNSRLRYQVISACRRFNKSTNEQYLNSSHLGLTSSSCKVYVCEHLSPECKYLHAATRLKAKELKFKYVWVKYGRVYMRKDDRAGHILVKNVDFLNNISNLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7D9</accession>
    <name>A0A835L7D9_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_004510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7D9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9418682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="273" mass="31906" checksum="66EF94ADA4635EA2" modified="2021-09-29" version="1">MTMPFRRVVKALQASRRLYTVKFPKDDQLKQKWLRNMRRDDWTPSKFSRLCSLHFEPCCYREGLDKKILHSYAVPTIFTNQPTIKEKIPVKRRIIMKTASTASTSAVDEFKENIKPIKRKVVEEECYPITSSAVASTSTTPFISLCADTSEVARLQYTTERLPGTRDVNSLKKQLAHYKTLAERRGRKLKNLQRKQQRTAKKIVNLETIIKDLKSKLEGEQLIMLQSSMSFDNKILSRYIMKSQGYSLSKEYPIEIKKFALTYNFYRPKLMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L7R8</accession>
    <name>A0A835L7R8_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000063">
        <property type="protein sequence ID" value="KAF9417964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L7R8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9417964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="249" mass="28283" checksum="127FC5C1CB6022D3" modified="2021-09-29" version="1">MCQTKKVVCPKCGGPHENCDSLIFACVNCKGNHISLSKACPAYKKERRIREIMSEFGCTYRKALECYISPKSQATLDTVAPGQPQLDMSSQNLFPSLGRKSLQINPEPTACSTYAEVVQSKVNGHPSLQLFSSPGKSKNKLNPDKEQASKERKRDVNEDWMFWNSEPDYTSPLPGNNEEDDKNNQRPSFNELLSRIKEIIFLRQSNLSTKVKSIIQLCLEWLVLVIVNFISKWPMIKVLWNLVNIQRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L942</accession>
    <name>A0A835L942_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_002708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000025">
        <property type="protein sequence ID" value="KAF9421236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L942"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000375">
        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000229">
        <property type="entry name" value="Small nuclear ribonucleoprotein U5 subunit 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9421236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="349" mass="38742" checksum="C6DF2EC219EE82E1" modified="2021-09-29" version="1">MPELEAKRKADDLSVVPAKRTRHEISVVGTREKAVVTSSVPRTSNLYAPIMLLEGHQGEVFTSKFHPEGKHLASAGFDRQIFLWNVYGQCENVMVMKGHTGAVMELCFSPDGSHLYSCATDNTVAVWDVPTGTRIKKLKGHASFVNSVSGARRGPELLVSASDDNTIKLWDARKRNPIASFDSGYPVTSVLFNDTAEKIISGGIDNVVKVWDIRNNQISYKIKGHTDTITGMALSHDGSYLLSNSMDNTLRIWDVRPFAPSERCVKLMSGHQHNFEKNLLRCAWSQDGSKVAAGSSDRFLYIWDTTSRRVLYKLPGHNGSVNDVDFHRTEPIVLSASSDKQLYLGEIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835L9P6</accession>
    <name>A0A835L9P6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Armadillo segment polarity protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_003042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000028">
        <property type="protein sequence ID" value="KAF9420856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835L9P6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001500">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01869">
        <property type="entry name" value="BCATNINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9420856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="751" mass="81559" checksum="F48B87839F2D1738" modified="2021-09-29" version="1">MKGMAQGALLHPLNHELSDTIVPESHDNYAGSDVPMAPSKEQQTLMWQQNSYLVDSGINSGAATQVPSLTGKEDDEMEGDQLMFDLDQGFAQGFTQEQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQLDPAQPTAVQRLAEPSQMLKHAVVNLINYQDDADLATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQMVAALVRAISNSNDLETTKGAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVALLQRNNVKFLAIVLSVCSNNKPAIVEAGGMQALAMHLGNPSGRLVQNCLWTLRNLSDAATKVDGLEALLQSLVQVLASTDVNIVTCAAGILSNLTCNNQRNKVTVCQAGGVDALVRTVVSAGDREEITEPAVCALRHLTSRHVESEMAQNAVIVKLLQPPSRWPLVKAVVGLVRNLALCPANYAPLREHGAVHHLVRLLMRAFNDTQRQRSSSGGGAAGGAYADGVRMEEIVEGAVGALHILARESVNRQLIRQQNVIPIFVQLLFNEIENIQRVAAGVLCELAVEKEGAEMIEAEGATAPLTELLHSRNEGCYSSVATYAAAVLFRMSEDKPHDYKKRLSMELTNSLFRDDHQMWPNDLAMQPDLQDMLGPEQGYEGLYGTRPSFHQQGYDQIPIDSMQGLEIGSGFGMDMDIGESEGAGAASADLAFPEPPHDNNNVAAWYDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835LD96</accession>
    <name>A0A835LD96_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_003497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000034">
        <property type="protein sequence ID" value="KAF9420276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835LD96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032331076" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9420276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="126" mass="12999" checksum="CA7DB3EE4FA5EAFA" modified="2021-09-29" version="1">MARLSILCVLVIVLSLYLERADAASRSVRSPQFGRPYPPFGPPPPPVRCFGPGCGPFGPGRFERRHHFNPYENNYGYIPPGAGRGSLSISKTISISAGGNAQSSASSGAGGGRSSAGSQASSFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G0P5</accession>
    <name>A0A835G0P5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_013866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000752">
        <property type="protein sequence ID" value="KAF9405363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G0P5"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013288">
        <property type="entry name" value="Cyt_c_oxidase_su4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01873">
        <property type="entry name" value="CYTCOXIDASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9405363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="194" mass="22319" checksum="1DA184960972883E" modified="2021-09-29" version="1">MANYLLRRALIDAVRVPVCARASSSTVSELAKIGNREWVGYGFNGQPNYVDRPDFPMPAVRFRADTPDIKVLREKEKGDWRKLTLEEKKALYRASYCQTFAEFQAPTGEWKGILGWSLAVASLAIWIYMGMKIFVYSPLPESLSEENQKAQLRRMLDLKVNPVDGLASKWDYENNRWKWQKGAMPVERCYSGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G1P3</accession>
    <name>A0A835G1P3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_014266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000938">
        <property type="protein sequence ID" value="KAF9404593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G1P3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04583">
        <property type="entry name" value="CBS_pair_ABC_OpuCA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9404593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="140" mass="15687" checksum="D4DA61E432738C75" modified="2021-09-29" version="1">MLNNAITITPEKSLSEAIKLMREKRVDTLLVVDGSGVLKGFIDVETLDRRKNKATSVSDIMNPKVFFVKKSSLLRDSLQRILKRGLKYVPVVDDHQKVVGILTRASLVDIVYDVIWGEDETTDTANETESTDVKQPQAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G2B4</accession>
    <name>A0A835G2B4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_013962</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000786">
        <property type="protein sequence ID" value="KAF9405204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G2B4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF2">
        <property type="entry name" value="RE48874P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="125"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="379"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9405204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="546" mass="60830" checksum="8E14B818EFE341D8" modified="2021-09-29" version="1">MREFGTVAQIRDIMTRANFYIVLLTVFLATCNSMVAGFENETNFNTLHPISRNGKIVLMSEELIKKIQNEQSTWHWTPWLRTRVEVNEDGIAQQTCPGGDSIESFPDSLFDDEQLRQGAFLLYVMFGIYSFTLLAIVCNDYFIPCVELICEDLKIPQNVAAATFMAVATSCPEFFVNVISTFLTESSMGIGTIVGSAIFNALGVAAVGGLATVVPIKIEARPVTRDVIIYMINVSVLVAFVWDGQIDWYEAVVLAVLYVLYFIIMFNSVRMFALYDRLVAKWCNKNNTLDIVEMPTAENGKSIEEGVDNKGFNDTTLSNPEKVSVVDNVETEVVKPKKSVFRWPKENSNLYKFWWLYTWPLKLVLGMTIPSPITYRRWYPLAFFMCIVWIGANSYCVSWSMTVIGHTFYIPESVMGMTFLAFGGCLPEACSVFIMSRRGEGGIGVSNALGANSLAILFALGLPWLIKTLSLVAENADQQAVLINSAGIDFVVGSLLVAVACLWITLYIGKFTLRKSLGAILLVLYVIFITFAILVEMGIIIGVEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3I0</accession>
    <name>A0A835G3I0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_014442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010001036">
        <property type="protein sequence ID" value="KAF9404248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3I0"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04245">
        <property type="entry name" value="AAK_AKiii-YclM-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04911">
        <property type="entry name" value="ACT_AKiii-YclM-BS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000027">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="entry name" value="Aspartokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035804">
        <property type="entry name" value="AKIII_YclM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006540">
        <property type="entry name" value="PRK09034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF67">
        <property type="entry name" value="ASPARTOKINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="304"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="400"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9404248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="601" mass="66537" checksum="11E42430B409735A" modified="2021-09-29" version="1">MKKLLELGVKKVKVIKFGGSSLASAAQLKKVLHIVKADVSRKFVVVSAPGKRSSDDIKVTDLLIAYYHAYTNNENTENICKTIVARYEAILDELAINKDVLVEIQQAIRQLVTLPKENNPHLLDAFLASGEDNNAKLVAAFFQQNGLNARYKNPKDLGIIVSDEPGNARILTSSLHKINQFKTTEDILVIPGFFGYTETGEICTFSRGGSDITGSIVAAGVGAEIYENFTDVNGIFVAHPGIVSEPKTIKELTYREMRELAYAGFAVLHDEALMPAYRANIPVVIKNTNNPDHPGTLITTSRKVEHEPVVGIASDQGFASIYISKYLMNRELGFGRRLLQILEELGLSYEHMPSGIDDISIILREKQLSIDIEEQLMERLEKELEPDELRITHGLSLLMIVGEGMRQRIGVMADSAQALADNRINLEMINQGSSELTASEYWDLIAAAYELNLEQKQARLNELATLFDMLSHQEETLASFSHGMRQKTIIIGALLPDPEIWILDEPLQGLDPQAAFDLKEMMKAHAAKGNTVIFSTHALDTAQQLCDELAILKKGELIYNGSVETLLEHAPNESLETIYLKMAGRQSDIPATETIVGESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G3P5</accession>
    <name>A0A835G3P5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_014132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000866">
        <property type="protein sequence ID" value="KAF9404861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G3P5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9404861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="819" mass="91765" checksum="18032228EF6D967C" modified="2021-09-29" version="1">MLYNYCYCLHIINKLRSVENCVGSFKPCYNLAHNARPNQGINIENLRRLPHRELKMAMSNEQFQQLLSTITANKRGTFASCTFTYDGKKNSDAVEAFLAAATVFKSTEKISDSDALQSLPLLLRDEAAVWWQGVKTVVTQWEDFCTKLRHTFFPEKTDIHGEANVTTEAFIARKRSLFSRAPPPAFTESQQIDLIFPLIRLDIRNRMPRDTVPTFYQLLETARGIEETLHEYAASSETGETGNAPGKKVKIRCTFCKNLGHTADVRRKKKRAEGTLSATVKDVSEGQTQAPSPSQPKFSCYGCGAPGVYRSNCSTCKKSSSPVKKENVAFCAVDAPEETHSRPVVFVEVDGQKGTAFMDTCAKMSVASYSLYQSLLKSGCKFIEKTVDLTLADGIKKEQVVLVCKAVVNLNGRNIATRFIVLQEARDNRTLLGVDFLQKAGVVINMPQYTWSFIDEPDLHYELYPEEFTIFESTIIKEMMTLPSPLSAMTVTDSEDTASVCNAMPTPPSTPPPAIMTAGEPETPTEDQQGITDYKLALIDLTSTPPSKKKPRLFDGYSPSFTDFMMRDAQINVHRENAELSPQSNSLFDANNWDVRIDSIDVVAHITPDQDKLVNQLLEKNNDVFNTKREPTKLIEHTIKTVDDKPISEHGEERRKKYVDKQRREDRGYNPGELVLATTHTLSNASRGVSNKFTPRRDGPYIIKKRHGPSSYEIADPQKADVVIGLLYSPCGREDDPESKFWSMAVRQGERRNAEDPGTRLHLLDHRRDAFRSRGGDCNITNPNNARAHDASYHRYVIPGVASPQRLPPPCAAPAGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4E8</accession>
    <name>A0A835G4E8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_012984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000553">
        <property type="protein sequence ID" value="KAF9406743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4E8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="61586" checksum="5F08DB9139F2E16F" modified="2021-09-29" version="1" fragment="single">EASGEDLSDEEILQKCEQQLNEMRNTEVNRESGNEINEVIRRKPKRFIRSDSVDVNNGKEKDKEGTYMQIVNHEVCITSVETLPKPIAMAKLLRSENITDILKIKYKSMYKVLIQFQRKDDATKLTECKKFKDMGLRCQLVQDMSTSFGIVKGIDLELSEEELINIFNADVEVLTVKRLKRLQSEGNWIDCESVRVSFKGNALPQYIYAYGCRFNVEPYVFPVTQCSGCWQFGHIIKYCPTKKVLCPKCGGNHENCTIKDFKCLNCKGNHFVLDKTCPVFLKEKTIRIIMSQKQVTYRRALQLFLENKKEFTDDFSQRFDNTPSTAITTTDKESYRDVLTRVVVHQQPVSDMDEDEEEEDNREDKDSAEKEKERSRHRSQWLNNFEWKKIWIKIKGIYNSELKLEEKILSTLKIIWEELKIKSALLHLARCASGCRGASIAYDILKLIYNYNKDGIKIILQWVPAHIGLRGNEEADRLSKLASETGNVTSYLPDYWEYFSMFKKVWFEKWKKYFDDISKEKGIWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4I6</accession>
    <name>A0A835G4I6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_011875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000382">
        <property type="protein sequence ID" value="KAF9408440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4I6"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="32"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9408440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="180" mass="19884" checksum="89A811FFE4D10856" modified="2021-09-29" version="1">MAYPNQLPPPPPQTMGSTNTVFITELRFDPSYLKTLPGILKAVVVLFNLIGFICIQSSAFWSNGRGVYFNIVAHLGLWFSGILLGLYLFHVVEKYHNIKWLKIEMIAYIVMVFLYLIASTIVVAFGAAAYSAAGFFGYLAMVLYGGDAFLKYKALMAGELAQGHRVQAKQTHVTTPPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4L8</accession>
    <name>A0A835G4L8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_012609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000484">
        <property type="protein sequence ID" value="KAF9407329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4L8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033202410" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9407329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="190" mass="22643" checksum="50DFDA92AA44BCA2" modified="2021-09-29" version="1">MFKIIILSIFLSVYSAYGYFTLPGKCPENVQLQEEFRLADFFNKWYQAYHYSSDGQQQNNCSVIQLETRATGIYLNQSRVDRGLFHRFFNVTVMHRKYPFYVLATNYNYYATVYTCEYSPLIDKHFIYVWILSRNELLNDVSKELAVRSLSRIGVDANKLVKDDWSKCSPKYYEDRQAEPMTFRYPVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G4Q9</accession>
    <name>A0A835G4Q9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000650">
        <property type="protein sequence ID" value="KAF9406029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G4Q9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="186" mass="20265" checksum="3C5EED017EF49F06" modified="2021-09-29" version="1">MEHTNNNDDQTRMRRSELARGGGGRGMRLRGLRGSMATRNGRRVRTRGGQRGGRPLVSEPVFCGMLENLPEGQPLETALHPKRARVLPPAVAKNPRSETLWSSLDMIAPSTPSTSRGHETPPPMLSHVDMAPSPAQNVGCGASSGSSTPQTTQPVNRGRRYSNTRRPLRDDELSALINYGSEEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5D1</accession>
    <name>A0A835G5D1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_013308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000618">
        <property type="protein sequence ID" value="KAF9406258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5D1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9406258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="85113" checksum="F7F4B567556DEAD0" modified="2021-09-29" version="1">MRQSLLSISLAYLWSFEHLIKNRRQEFSWPLPTSSRRSTTSAVGGRRTQHPAVTTDNIKDMDKKLLSNTPEDDDAQLNTFKKRRAGHKGKVTIFKNYIESLNSKKKIALTELEILQLKNRLEVYKTLEHDFDVNQTLIEDIVGVSDEQLKEREQFDSEYQNQLALAMQLMRDSESTGITDGSESSAALRQLIDTVSKNLRALDSLDEKTQFWDTLIIYLVASKLDSVTLRHWEVYKNTLNAKPVLQNLKTYLKDRADLLQTLEEKHKQNHVDIKSNKPAQNQTSTSRSPSCPLCKAQHYLFSCPDFKQMTVEKRIEKVSKMNVCSNCLYPGHEKKTCRGGTCKYCSLKHNTLLHIEKPKSSSITCTSTQQTSVLLSTTLVDVLGSDGTFHTARCLLDNGSTSSYVTKNLCTRLNLTLESINGSVSGINGQKTNILYRTNIQIKSLHNSFTMNSSCLVLDEISNLIPNIHQLSRFWELDSLSDSQNTDPCDADACEVIFKQTTTRQSDGRFVVTIPFKMSPDCLGNSYYQAKKRFLCLENRTDDESTLLEIATGVNTELKKYQFPLRKWKTNCPAVLRKLGFDNDSKDNILKHSTPQSWYYIPSKQNPADIITKCTNAQQLINSDLWFSGPDFLRNDDNKCWPEQPRHLSVSDLPEIRSQSHLTHTDENSFIHNYSNFNKLTRIVAYMLRFLNNARYQLAKIIQQHSFPDEYLLLLNNKKLPVGHKLNSLNPFLDEFQLIRVGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5E4</accession>
    <name>A0A835G5E4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small VCP/p97-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_012719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000499">
        <property type="protein sequence ID" value="KAF9407180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5E4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904153">
        <property type="term" value="P:negative regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904240">
        <property type="term" value="P:negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055366">
        <property type="entry name" value="SVIP_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35269">
        <property type="entry name" value="SMALL VCP/P97-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35269:SF1">
        <property type="entry name" value="SMALL VCP_P97-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9407180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10774" checksum="CBB9ACEBDA0A30DE" modified="2021-09-29" version="1">MGIFTSCCKPSASEVLTPDSETRRRQQVEAAERRAAQEAARGVKDPSKVLRNQQRSEEMEKREQELNMQGGANLRVLDIRLRRGSKWELSERSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G5G9</accession>
    <name>A0A835G5G9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_013366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000631">
        <property type="protein sequence ID" value="KAF9406167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G5G9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9406167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13156" checksum="7DA51842FB69A1F7" modified="2021-09-29" version="1" fragment="single">QRFPLKEFYVLSSVEISQEVNPPVSFEGYFSRRGFSSSIDTILWRLPSEALIMITPSCDQQERIPKCCRALVKMDCLVFVRNSLTEILVPLKPVLAFQTLDLTSQQENLTRMGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G701</accession>
    <name>A0A835G701_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HF086_000831</name>
        <name evidence="10" type="ORF">HW555_011438</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000340">
        <property type="protein sequence ID" value="KAF9409091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000572">
        <property type="protein sequence ID" value="KAH9635110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G701"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9409091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9635110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="115" mass="13216" checksum="7833D123CB640776" modified="2021-09-29" version="1">MSNLFGKLIAQLKSKEFRQYLMSTHFWGPVANWGIPLAAIADIQKDPSIISGKMTLALSIYSLMFMRFAWRVQPRNLLLFACHITNEAAQLTQLARFVNYHYIAKVPEQKNKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G773</accession>
    <name>A0A835G773_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BK channel</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Maxi K channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HW555_011726</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BAW_Kor-Di-RS1</strain>
            <tissue evidence="20">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000369">
        <property type="protein sequence ID" value="KAF9408662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G773"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000035">
        <property type="entry name" value="Calcium-activated potassium channel slowpoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000008">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033058278" description="BK channel" evidence="18">
        <location>
            <begin position="22"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="19">
        <location>
            <begin position="822"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF9408662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1147" mass="129154" checksum="028E06945A7E72D2" modified="2021-09-29" version="1">MYVVLVFILSIASLIIYFIDASSEEVERCQKWSDNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTIPPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNILKTSSSIRLAQLVSIFISVWLTAAGIIHLLENSGDPLEFENAQKLSYWTCVYFLIVTMSTVGYGDVFCHTVLGRTFLVFFLLVGLAIFASCIPEIIDLIGTRPKYGGTLKNERGRRHIVVCGHITYESVSHFLKDFLHEDREDVDVEVVFLHRKEPDLELEGLLKRHYTTVEFFQGTMMNAVDLERVKETARPGARRPVQEALYHCGILSRHHYESNRPTEGENACLVLANKYCQDPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYLLNIPSWDWKQGDDVICLAELKLGFIAQSCLAPGFSTMMANLFAMRSFKTVSLLFYYSTYYKMPRVLSETDPYSGSNDTMRHFHSHKKWLYGLMTTCEVPAWRCTPRHLVPRLSGCRSNRPQIPRHTSLAERLPAGYGLRDVHGNTVDLLHGNELPASERLKLLLLAIEIKGEEGADSKISINPRSAKIHANTQGFFIAQSADEVKRAWYYCKACHEDIKDETLIKKCKCKNLTAHQRKVGADIDVGMMMMQTGMVKQSLNTYRACLDDDHHPPPTFTPPELPKKVHVRGEIARERGEDTSLINRNHRSVAPTTLLSPSANQLVNTTTTRQVNKVKPNVNRAPPDTNPQDQDTNYQAYHLAYEVKKLMPTSRSSGGNQNSNGVSLPAGLADDQSKDFDFEKTEMKYDSTGMFHWSPARNLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSAGRRGSVYGANVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTPESLANSSPQDLFLHLCILIVVRDRCRVGQISLYDGPLAQFGEAGKYGDLFVAALSTYGMLCIGLYRFRDTSSSCDASSKRYVITNPPDDFSLLPTDQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G789</accession>
    <name>A0A835G789_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HW555_012106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BAW_Kor-Di-RS1</strain>
            <tissue evidence="7">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000408">
        <property type="protein sequence ID" value="KAF9408084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G789"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000003">
        <property type="entry name" value="vacuolar protein sorting-associated protein 45 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF9408084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="571" mass="65100" checksum="F94CACE9B008CCB9" modified="2021-09-29" version="1">MNVIQAVKLYITRMTEESGPGMKVILMDKETTSIVSMVFSQSEILQKEVYLFERIDSHSKWDNMKHMKCIVFVRPTSENISLLSRELRYPKYGVYFIYFSNVISKADIKTLAECDEQETVREVQEVFADYLAVDRHLFSFNFVGCLQGRSWNPHHLQRCAQGLLALLLSVKRRAVVRYEAASEPCARLAERVRDLLRREAVLIDNNIPFNGEIPTPQLLIIDRRDDPVTPLLNQWTYQAMVHELLTINNNRVSLAHLPDVHKDFKEVVLSSEQDEFYAKNLYSNFGEIGQTMKSLMDEFQKKAKSHQKVESIADMKNFVETYPLFKKMSGTVTKHVTVVGELSSCVTRHNLLEVSELEQEISCQSDHSKHLQRLKNLISNEAVRHHDAAKLVALYALRYEKHASNALPSLIEALKTRGVPENLVKAVVNLLEYGGAHARQSDLFGLQDAVKITKRLFKGLSGVENIYTQHTPLLKDTLEDLIKGKLRENLYPTLGGDDGAYGRRPQDIFVFIVGGATYEEAQCVHQINQTYPGVRIVLGGTTIHNSTSFFEEVKAAMQGVHRTHTRHIRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G8L3</accession>
    <name>A0A835G8L3_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_011412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000335">
        <property type="protein sequence ID" value="KAF9409133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G8L3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9409133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="689" mass="80794" checksum="E2ACF6C1FECF1178" modified="2021-09-29" version="1">MNTDPLNIENQEIKPKISKREQKLIKKIKTMKIQHEKEKRNYILLLNRYRFRLNYLKRKISTLTGEISNEAEKTKNEDKKQLFDRLLSAEITQKFAKTANRKDKRVITKLIDKEKFKKFKVATDLRKVHLRERFKKNARNNINIQKLVEKFYEDDINSRITPGKKQYKKKHGIVKQVRYLLDSIKNLHKKFLAENTNIKISYTTFTRLRPFWVSLPTDDRDTCACLLHTNFNLLIAALNKNNILHVKDSHNLIKEICCDKYRLDCLNRKCASCKNKTVPYKEFRNDKEIQYMVWERDTKKVDTKEIKIIKKKTKRSDPRNLIIELENMLPKFLSHTSNIVNQYATVKCLKESLTTNEALVHMDFSENYSYKYSEEVQSMHFGGSRGQVSLHTAVVYLKNDSNATQSYSVCTASECTRHDAAAVWAHLNYLIKFVFNRSSQINRIHILTDSPTSQYRNKYIFYILTQLRNDFPDLNLVTWNYQEAGHGKGAPDGIGAVIKRTADYELKCHQDVGDFDAFVNIIRRNIKNVEMGIIQEHEIKLRELMLPKDIATFKGTMTVHQVIWAADSAYLEFRKQSCFECISVACKHGKHMRFFKIYNTPIGSTMENVKVIPENKRIKVLSDVTIRYANTDDPMLHDSTPSTSSLRSIRHSWANKCFINNYTKATDHEKEFLDFLKKCEDDDDDPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G976</accession>
    <name>A0A835G976_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000270">
        <property type="protein sequence ID" value="KAF9410278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G976"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="101" mass="11472" checksum="5E3795761B61761C" modified="2021-09-29" version="1">MANFVSACALELEYSRSVHLILDAAGELCCDPYTPSLSVEKSPSQWFTMTAATPAKPPPPEKKKTKTKRRKRSQKKKQKENGHTAQFNYIMERPPFTEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9I4</accession>
    <name>A0A835G9I4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_010390</name>
        <name evidence="9" type="ORF">HW555_011225</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000321">
        <property type="protein sequence ID" value="KAF9409401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000177">
        <property type="protein sequence ID" value="KAH9642737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9I4"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9642737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="83" mass="9490" checksum="0EE7CE9AC6EAF235" modified="2021-09-29" version="1">MAEQNTETTTTDVENTYTAPGNDPKNMQEVTQYVQSLLQNMQDKFQSMSDQIINRIDEMGTRVDELEKNITDLMTQAGVENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835G9J6</accession>
    <name>A0A835G9J6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HF086_015703</name>
        <name evidence="9" type="ORF">HW555_011197</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000320">
        <property type="protein sequence ID" value="KAF9409422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000301">
        <property type="protein sequence ID" value="KAH9639852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835G9J6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09352">
        <property type="entry name" value="LIM1_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000028">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000036">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047245">
        <property type="entry name" value="Ajuba-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="500"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="565"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="626"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9409422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9639852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="715" mass="77608" checksum="8F8C21B3766B1855" modified="2021-09-29" version="1">MDSSRRSNTDEQRCIMGLQDLKLSNKVEDVTEQAHGAVTSNTSSLAKTRPVGAIESFVLDNGQNNRQDYSFYERSNVIAASKFATPKRVETIASINKRDINTAALPSSPTRSIDSISQRSLSYQTDDLYEIPAIPNAQYPPPVYENIDYYGEQRSPQPPYYHQLYGQAPPPPVSDGYYDTRYSKAQPQVPVNSKTTKPNPLVYENMLCSDNDKKSEFKPQQNHDQRFIQQGSVPGPQVPNTGAIRSMAQILTSDKIKIDKAPPPPPYNTSQDNPGSDYTVMKSAPPKYTDVSALLKSDNTISFDDKVVTIPSTAIYASIAPSAQRPKANIATEVQTATASPKFFHPKPNIGNSIGKEKPLINGGYSAKPQVGSRMQIVEDTNGSDYVCMTGGSPAAVVAAANRDNVSLASESITSRNLVSGLTSLCSPAQSPAPSPTPSSVSQVSGGSRGSGGRGKSLLPYSITPPRPPGPSEAQRKIEELTRQLEEEMERQDEEGEYFGICHTCGAGVTGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGKVYCEEDYLYSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDNKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDRDFHVDCYMCCVCGMQLTDEPDKRCYPLAGKLMCRACHLATIGAASGPGLSPAPHLSPASYQYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GAT8</accession>
    <name>A0A835GAT8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000234">
        <property type="protein sequence ID" value="KAF9411138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GAT8"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="216"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9411138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="513" mass="58984" checksum="95CB719828AFE5E3" modified="2021-09-29" version="1" fragment="single">MSPGSTICSECFDLLQNRVNTMSEGSAMPLPALGHRRICFPCGNSILRAPRTYSVRHDRQVSRMERVCAACWRSATREVQRQQQHDIRAANNRFDFSNIRMMPPYLCHYWLGFNADQFYDLLNSIPNLAEQVPNASIALCIYLVKVGYPFYKARTTLERWMSKARNCLMGDFVPLHLGFNHLTVQDVASRNKIIPEGLFGNPDLPPDVKPAIVICDATYVFVQSSSNYLFQKQTYSLQKLDNLVKPFLIVCCDGHIVECLGPYKATLNDATITSLNLINEGSCIRSFFRRGDIFLLDRGFRDVINELQEHGFVTHMPESLLENEHQLTTQQANRSRLVTMCRWVVEIVNGGIKRDYRLFRHVFNNRAAMHLNDDFRICCALLNNRLFLVNHLAIYVEQENVNRRRASFQTIDGNHPHLDGFPQLTISDLKRFALGTYQLKQARSYFGEHVRQSGIYSVEVNNEIDEDIPLILGLNNYLLRGRIKSRHVNSRTYYTYLLISRDDAVANTLQAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB17</accession>
    <name>A0A835GB17_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable arginine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HF086_011101</name>
        <name evidence="14" type="ORF">HW555_008351</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BAW_Kor-Di-RS1</strain>
            <tissue evidence="14">Whole-body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="G3 (Bethesda)" volume="11" first="jkab311" last="jkab311">
            <title>Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control. .</title>
            <authorList>
                <person name="Simon S."/>
                <person name="Breeschoten T."/>
                <person name="Jansen H.J."/>
                <person name="Dirks R.P."/>
                <person name="Schranz M.E."/>
                <person name="Ros V.I.D."/>
            </authorList>
            <dbReference type="PubMed" id="34557910"/>
            <dbReference type="DOI" id="10.1093/g3journal/jkab311"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">TB_SE_WUR_2020</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000160">
        <property type="protein sequence ID" value="KAF9413414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACEFF010000534">
        <property type="protein sequence ID" value="KAH9635711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB17"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000814243">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="13">
        <location>
            <begin position="425"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF9413414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9635711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="540" mass="62238" checksum="F57EF4A11E76234D" modified="2021-09-29" version="1">MKPKIMLMDKILPHNVDKKYILRNLRNVTISYKHAEGNYAVNINKSGSNFDASTQNQSINDLSFHVEKNTFIKTILENIKTPRPRQLVKPKKIVIDFSSPNIAKPFHAGHLRSTIIGNFIANVNTYFDNNVTRLNYLGDWGTQFGLLQYGLKSKNINVKDLQNDPIRILYDVYVYANKLASNDNNIQEEARKYFSEIEQGRMSLENWKNIREVTVQELEKVYQRLGIQFDTYHWESDYNGGVIKPIMDLLEKKNIIKIDESGKKIAYVNNRNITVLKSDNSTLYISRDIAALLDRYKKYNFDKMLYVVDNAQTDHFAAVFDIVKQIDQKCTDGCEHIKFGRLKGMSTRTGNVVFLNDILDEAKRKMHDKQTLSKNTRTGAMNDETCDILGTSAVLINDLKQKRLKDYTFSWDKALQTEGDSAIKLQYLHCRLWSLEQNCGVSLPDTCEAECLSEEVIGDVIAELAKFDSILQKSLEEYEACIVVNYLFRLARHVNRMFNEVRVKDVNSDLAAQRLLVFYCSRLVLKTALTILGIRPLKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GB24</accession>
    <name>A0A835GB24_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_010453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000262">
        <property type="protein sequence ID" value="KAF9410451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GB24"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032645614" description="Carboxylesterase type B domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9410451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="555" mass="61206" checksum="12F3357A03717D28" modified="2021-09-29" version="1">MFVPVLFVFFLAYAHGLQVNTTEGIVEGSRAVDGDYFTFYGVPYAGPTSGPNRFKAPIPPKPIPGVLRATDSNIFCAQPSSRGLIGVEDCLTLSIFTRNVTSPKPVIVFLNSDEYTNTNNQPISYRRLVEQNIVFVTLNFRLSVFGFLCLGVQEAPGNAGLKDVLQGLKWIKSNIANFGGDPNNVILLGHASGGAMVDLLTLSPQIENLAHKAIVLSGSALAPWAVAYDPVGYANLLGTKLEYEHKTPEVLAKRLSNTDINVLHTALNDFKFFNNTPLFAPCVENPKLSPNHTVLPDAPINILRSGKYVHIPVIYGYTNREGTMRAEEADFGNWLTLMQSNFTSFLQVDLKLNNNKTAVAASIRDFYFGSSPISMGTIEDFLDYQGDTLVLVSTIRGAKERALTSKSEVRLMEFAYLGTLNSNWIHNQIPLSGAAHGAFLNYLFGYDLRPADEAVSRALVGRVSAFAYNWSNNTWAAITKDATNYLYYGGNGAPTANNTSIYVEEPRFNPHVQRMSFWGNLYEKFYVAPTQPSSSNMIVSSLLFIMLCQVTLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBF6</accession>
    <name>A0A835GBF6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_008148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000152">
        <property type="protein sequence ID" value="KAF9413702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBF6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9413702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="122" mass="13793" checksum="A18A8913D665F94A" modified="2021-09-29" version="1">MKPYDGTRERGSCERIFNYRLSRARRVVENAFGVLSSVYRVLRKPMLLESETATKVVLATVRLYNYLRSNPNFISPGTFDTVQENGDVIPGSWRNEPPSQSLQPMAVVPRRATENATTISPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GBN5</accession>
    <name>A0A835GBN5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_010163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000241">
        <property type="protein sequence ID" value="KAF9410921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GBN5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9410921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="250" mass="28773" checksum="09FFF5E7C47D8736" modified="2021-09-29" version="1">MDIHFSKCVMMSRGKPLPQAEILDQLLTKFLGHSYSDNTVGNIILGKSVGNKHVDPTSENLDINVLDVYSARKIISFAKQKHEERTIAELTRRQKNFRRFHKALVDTNPNNTYITDKAMHFLQQSIYATLARMNVTYPFQKKYHNYLSYQISVLYGSALATIAKMESLLAQMKTFTQKTHFIWFLFIYEKILTCNIDITNIVQRIFILHEEYIMNRGPKKGANDNAKAASPSPPSDFDEEAMHPPSHKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCB4</accession>
    <name>A0A835GCB4_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_009821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000227">
        <property type="protein sequence ID" value="KAF9411374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCB4"/>
    <dbReference type="OrthoDB" id="6610013at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032270528" evidence="1">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9411374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="373" mass="43429" checksum="900D244A3A865AD9" modified="2021-09-29" version="1">MVKFWWMFMLFAKIASASDNELPSPEVQKESRFLPLFEVKRYDNRPLGVGPGGLPPLTTVPIAGERCSSRLESALDQMKRRKRTQPKNLDTPLSQSIDLNGYSLYQQMRSAPVDMYVTRMRVRLPQNSNWVRVEKCYFDPRNVSLDTMLLFHDITISGNVDLYDANDLDRGLPPSRRLRRHFAESRSIDGPFVDNYARSRGNNGCNMILRLRKAGIGFHTRPLNQQPGKFNVKTDSEFVEPGFISVYAYGCEKYINRNSVRNKDNLPLKRRKRSDEFSFDPRLRQIYNEGVDSRAADNNWDIVYEPRSRVNYERSKLFRPDDELDEAEDISREMEDIFTKGIRTLLTTYMKKELQPAIKDTLMRNMGYVISYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCF3</accession>
    <name>A0A835GCF3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_007619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000132">
        <property type="protein sequence ID" value="KAF9414482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCF3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="893"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9414482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="126316" checksum="A21487BAE33958B9" modified="2021-09-29" version="1">MEISELSFVSFLNSTTTSSSKLGDMAAKVAIQNFDLSYTTLLYFNSTICFGVEVFLNIFNYSVLINRATLQQNNHTRQYVLFATDAADVEIMLDAMIDLEMDNTGKFIIVCESPVSNECDEQDIVDMCWNYRIVNIVFIRLEGTEPIGFTYYPVADGICNNLKPIKLDYHNNYTHTSYGEVFSNKFRNLNFCPLTVSTFIQPPFIMNITNGTPIGSDGDLLQLLIYGLNATLKMMTPSRGTGWGWREKNGTWMGSLADVKDELANFSMTSAALTLARFTDFQISYSYLVTKVVWVTHPAQIQNVALKLLHPFEEDARIALLVSFFLVVLCAFLIKTYLWSSTCNVNGEAELSKSMVFHAWMLCMGQSISKFPTKMSFLQMVFIWIWYCFLIRTVYQVYLISSLKGKFYVEQFQTIQDAIDAKYPFGGGPALKDYYIDNAVVHDNWVNIDTPQIMPTAMHLVEGMNFVLAMNLDAAYIAIKQSKVNLHILPQIVISSPAVLFFKKYSPLLEPIDLVMGRLTAAGFPEEPVSELGLLAAKIALYSFEWRYLTVIIFNTVEVIGLKTFLRIYQQPVVVKLGKFVSSSSRRSDVKQMVIFGEDSSEISSTLRWVVRSKYDSDGKFIIICAFRNQDCDERKIFITLHDLFITNVLLLKPSQLSNKTSVYSYHIATSERCNNHIPYQLNISLDCRNDECLKGLFDEKLSDFHQCSLYVSTIEQPPFMYFNNTTENAKGIDAEIMKLAADMLNANLTLVKPSDNSDPGHYTNHNWTGSLGDIYNKRIHVSACSAPLTSNKYGNFQISFTYYSMDIVWAARLPTQKPSWEKLLSPLTILLRVLLVLMFISIGFANTLCNTNIGRKLRTAFLIRSPKYSLLFYSWILFLGMPILRSPSRRSFLVLIYTWIWFCFVIRSVYQAALVNSLKKPAYLPNLKTFQDVVRDGYPFGGLAIFRDYYTDDRAIYDRWIVLELPQLSETLNNILDGTTDFVLASNKEVIKHYLMQYNGIKKLQIIPEKIVNSPTVVYYKKFSPVTNPLNVVLRAATEAGFIQRTFDRYLDRDRKLFRLHKNQPQESLNIENFTGCFVLLILGWVVAVTYFVVEYICGNLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GCY9</accession>
    <name>A0A835GCY9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_007350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000122">
        <property type="protein sequence ID" value="KAF9414881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GCY9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9414881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="148" mass="16551" checksum="1DE4ECBF0024266A" modified="2021-09-29" version="1">MASSGDAPDTILPKHMTYSKSRVPILGALIDYLDTSIQYLRNKTFAQAEKLHAKSSKATLSASFLAFVCLMLGFVCNVKFEVVTIDEEPLPDDLHFMLMSKEDKLYIDDIDVSRVMWCVEASDSLVILISSLLIWNSSNVVTSYYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GD99</accession>
    <name>A0A835GD99_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_009004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000187">
        <property type="protein sequence ID" value="KAF9412480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GD99"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9412480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="79373" checksum="FFF21C70402AC4F2" modified="2021-09-29" version="1">MKVGSHTIHKQIMEYHQINCFNINFRFFKFLGVWPGKNPWRYYNYYSKAFILFFVIIFSLLFSINFYFLPRQLDIFIEETIIYFTDLAVTSKVFTFVFMHDKIIEILDILECEVFQPDDDEGLIILEKAKKFNRTYCKIIMSVSYLSSTLHILSPLISHLILDVELMLPICRYAFISDEYRLMFIYPIYLYQSVAIHFHVLYNVNVDIFFFGLMVLAIAQLDIIDKKLRKVTDENKINETDGEVSSSLTHANKKDVMKLNQCIIHFIKICRFCKLIEDVFSATLFVQYSAASCIICVCLCRFTMSQLLTFSVYNCDWTSRSRQFKSNMRFFVDRTNKPLSVTGGKMFILSLDTFTSVKEMIFYFTDLAVTSKVLTFVIMHDKIIEILDILECEVFQPDDDEGIIILKKAKDFNKSYWKIIMSVSYLSSLVHIMSPLISHLILGVELLLPVCRYAFISDQYKLMFIYPIYLYQSASIHFHMLYNVNVDSFFLGLMVLAIAQLDILDVNLRKVTAENKIEDSDGEAARSPIHRGKEDVMKMNHCIVHFIQVCRFCELVKDVFSATLFVQFGAASCIICVCLLRFTMPAPMGYYIFLATYMTVMILQIMAPCWLGTRIMVKSQLLTFSVYNCDWTSRSRQFKSNMRFFVDRTNKPLSITGGKMFILSLDTFTSGELLPVLNLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDX6</accession>
    <name>A0A835GDX6_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000113">
        <property type="protein sequence ID" value="KAF9415321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDX6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="77" mass="8302" checksum="48416D13D1FEECFF" modified="2021-09-29" version="1">MSSKENTGPRDCLSCRVVGGVGLVGIGGYLANSACKHKTLPGKYGLSVLSFAFICLGVARYKQTFPFNKNVEFKNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GDY0</accession>
    <name>A0A835GDY0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Golgin-45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_008966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000185">
        <property type="protein sequence ID" value="KAF9412550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GDY0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9412550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47210" checksum="D180E0567584AEF1" modified="2021-09-29" version="1">MDKLYNTFNPKIMSKTRTAGDGMESDENTSERVQDVGTNVTRTPERKGSALPTRLVQVYATKVIKSDKKKSINMKTPKFVPYEPYPAAVKPMTPQIASKEMKKSRNNMDINTLITQMSQMNTNLNEFKPRPKLNSTGDKTGQDVDAPSPEKIEMQKKIDSLTHENESLKEQLKQQVQVNKELKTMLVASMGEDLETQVQSLNEDKKYLANALLSSAQHLSTHQEQTEWLAGQCEVWRSKFLASSLMVEELAQCKKLLNEKTDNLQQAIKKLLDERYRARDMMLCTYKNLYSLHEKWLENIAITEYTGNSKMYNRPIGNLNFNATIPHSTNILDMTSVNLKLAENISSSVEKQDISHLNSLPTATEGEKFAESVMATPLDVKKVSEAPVNALVHHAYSSSGNTVRPIASCVHCHGKVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GEE3</accession>
    <name>A0A835GEE3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000137">
        <property type="protein sequence ID" value="KAF9414283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GEE3"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11467">
        <property type="entry name" value="bHLH_E-protein_Da_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000001">
        <property type="entry name" value="Putative transcription factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="462"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9414283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="602" mass="66096" checksum="0813EC37BDEB4C06" modified="2021-09-29" version="1">MALRHDVTNMDTSFLPADPPPISEIIYEPRTDLATEYFNTFNQICENYRSDSDVNLRQTSDSLRLSSEILDGVRSEYVSSDFTGKDFETNAQKVFLSGKDEQIFQFGQPDASALLRHRARRRYNEEHGLQPPATTSQESGYGSDEFGHDSPSRYASPKGAGAGAPYQEYYAGGEWSAPYYQPPPAYQHDPYATSPGIAGAPMYGGAGATPAVGAVGTAEAGSLSSYGSSPSTPQSNWVSSGVSSPPSASTPHALAAPVLPNGHHAPMPVFQPTGMGAPAEQRQLDEAMVFLRDHTDCGARMEERLDDAINVLRNHAEAPDLYPQDLHHQPPAAVSRLGVGGALLQTEPPVKMERHVLPNTKKRKEPPDSGVESKPSSSGSADALANKPPNSKRSRRYGSSQSSTNPAMPSCSSADEDDMDPDTKAARERERRQANNVRESCSSADEGDDEADPQAKALREKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEKAEEAPKLLPAPLQHYQPMPGMEYVSVAISLEDRKIHRKILMQVFCKLQLISEISHAGHNEINIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFP5</accession>
    <name>A0A835GFP5_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_007721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000136">
        <property type="protein sequence ID" value="KAF9414324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFP5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000189">
        <property type="entry name" value="UDP-glucuronosyltransferase 2B14-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032665730" description="UDP-glycosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9414324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61479" checksum="9A8575F3C15CB226" modified="2021-09-29" version="1">MRPRLLWLVLAWAVSAEAARLLAVLPTNTKSHYAMYGRLLEALAKKDHHLTIVSHFPMKNPRSNVHQISLAGTIPEITNNLTKQNDSLKPDFIRNLEQIMKECVDACETAAKVPEVKALFNSTETFDLVIVEVFGSDCFLPLGKKYGAPVVGFLSSVPLPWLNEQLGNPEATAYVPSYMVGYGQRMSLWERFANTMAVIIAKILYRYKSQIPSQAISDRLFGPGPKLETLAQNYSLVLSNSHFSINEVRPLVPTLVEVGGLHLNDSPVLSRHMQKLLDASTEGVIYWSFGSMSRIETIPSDTLSRIFDVLSELPQTVFIKMDRRMLAQNLTVPDNAYTMDWIPQHATLCHPNVKLFISHGGLLGTQEAVACGVPMLMVPLYADQALNARAMADRGVAEIVNLKNTDKDTWRRKLRELLTDRRYKDRATELKNIFLDRPMKPLDMGVYWIEYVLRHRGASHMRSPALDLTYPQYMLLDVIALSTTIALLTVYILHKLFRYLCTRCIRWWPKEKLVFEKRLLRKNISFFLCILWKYKVKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GFP9</accession>
    <name>A0A835GFP9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_006946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000111">
        <property type="protein sequence ID" value="KAF9415419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GFP9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="524"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="744"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF9415419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="822" mass="92548" checksum="5E71F7446BE31314" modified="2021-09-29" version="1" fragment="single">PNRASKIIALVPNEHAPSDASENSESETEMHDDPRAYASSPLSSSAPSITSSLANLTISTSEDEEPNIDNNDVIPDSIVREIGESNYENVPSLSAIPSLPSTPMVPIAFSSPLSSRNTRSRKQPSTVPAKKAKKGKKFQLSYKWKVAQFRHRATVEEDENGEYINLPEDVDSPLSYFYLFFLKMSLTNLYSVQQTAKSIQLSEEEFKDFLAIHIIMGIVVMPSYLDYWSDKFRYAKVGDIMSLKRYQQVRRYLHFVDNNMDDGDKYYKVRPVVEQIRQNCLKQQKTETKFSIDEMMIAIDHKPAFVFCDNFFSSPELFFILREHYGIFALGTIRGNRLRGAETILLTDKAMKKKPRGHIVQAVCNQNRLAIVRWNDNKAVTLISSFVASEPANRCAKRSKTETAKVSKPHVARPSSPVKYDNIGHFPQRWKKVVADTAKRRPSFIALNCYYQASYKKTAKMSTILEKIAAIESEMARTQKNKATALHLGLLKARLAKLRRELITPKGGGGATGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGCIKYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCSLIFIVLDVLKPLQHKKLIEHELEGFGLRLNKQPPNIHFRKKDKGGINLNTTCPQSELDIETVKTILSEYKIHNADITLRYDANSDDLIDVIEGNRVYMPCIYLLNKIDQISIEELDVIYKIPHCVPISAHHKWNFDDFIGKDLIRIYTKPKGQLPDYNAPVVLHADRTSVEDFCNKLHRSIVKEFKYALVWGSSVKHQPQKVGIDHVLCDEDVVQIVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GG54</accession>
    <name>A0A835GG54_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_006406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000095">
        <property type="protein sequence ID" value="KAF9416154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GG54"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="1">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="309" mass="34693" checksum="B67B39DA3BE5EE25" modified="2021-09-29" version="1">MNCDSCGSRFTDGVQCGLCKKHYDFPCAQISESGWRKLGVERRAVWKCTTCRGRASPAPATPTPDPPSLENIMKEIQALKAHLTGLPTLVEDVKSIKSEISEMKLSCEFLSGKIDDFATKLSAIEARVSSLEDLSENVSTLQSDVGMLKLQLAVNDQRSRLNNVEIKGVPEKPNENLFTVIEAIGNAVNFSIPKSQINYLYRIQVSNTKEKSIVVNFVNRYVKEDFVASARAIKTLSTADVGFKSVSRRIFVNDHLTADMKLLLNKTKLRAKEFNFSYVWVKYSKIHVRKSDSSRVFIVNKEEDLNKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGC1</accession>
    <name>A0A835GGC1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HW555_006265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BAW_Kor-Di-RS1</strain>
            <tissue evidence="10">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000092">
        <property type="protein sequence ID" value="KAF9416311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGC1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF9416311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="509" mass="56753" checksum="C00692E374FC34BC" modified="2021-09-29" version="1">MVYSLTYTFKTNFVVIRLIASMAPNLLLLDLGMAISFATIVIPDLLNAQTGLSLTDTQASWFGSLSFLTQPLGAVISGPMVDYVGRKKATFLVNLPHVMAWIIMYFAWNVPVLFIGNALLGIGTGIMEAPINSYVSEISEPSVRGALCTVTQLFLSIGIFAMYFLGSVVTWRVAAIICISIPFTSMLLVLVGAVPDTPVWLLSQGREKDALKSLCYLRGWTTADNVKEEFNELVVYSKNIEGCVICWKKNQAQQECDHSKINRIKRFFVEFNIVMLCKETLRPLSLTMLYFTFYVMSGLTPIKPNMVNVCSAMGMADESKNIAVMVGVISLLASIIVIGMIKSLGKRKLGITAMLGTAISCTALSIYAHTQLDDKVFSYDPTTFPKEKSMIPLIFFYLLTVCTGFNVSWVILSEVFPFRSRASAQGWGAAWNYVVTFIGTKTLIDLETHFRLTGAFATYAAFAYLGTIYLYFFLPETEGISLQEIETYYNGELRIFADDWFINLFKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGF9</accession>
    <name>A0A835GGF9_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_006233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000091">
        <property type="protein sequence ID" value="KAF9416386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGF9"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9416386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="290" mass="34185" checksum="49B2BECFC7CAED99" modified="2021-09-29" version="1">MTSLASSTNIDESPLHPLYLPEEITDETYNALIRQRPDLESIFRVQRKAQIERQQKNKENMYINNEEQEVLLVENEDNDITRPLREFEDERTTIEVNPALVPEFTRAEKQRLPFISHKRQRFNDTKRVELFVNNGWDRAWDNAWWAANCYTCYAEDEILDDNKNPKQNLCHKAFQTNDGRYAATQSFFKSGCYYSWEYRKRGYWKYRRYYWQGEDEASPGTHGSTLHRLGAYTKGCVKRFSDVSEIFTMRACRGLSAFVARAVYCLYMSFFYSTVSCQPIPPVSENAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GGK2</accession>
    <name>A0A835GGK2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HW555_007208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BAW_Kor-Di-RS1</strain>
            <tissue evidence="8">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000119">
        <property type="protein sequence ID" value="KAF9415052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GGK2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF9415052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="360" mass="40473" checksum="85C242B2D0A16838" modified="2021-09-29" version="1">MTPTNGEGAEPPHIVILDGGFSTQLSCHVGHVIDGDPLWSARFLYTHPEEVVNTHLDFLRAGADLIITNTYQASVEGFVEHLGITAEESFELIMRAVELAKRARSAYLEEYQDYLQNGKYIHSCGNTLQYAGSECHRIPLIVGSVGPYGAHLHDGSEYDGSYADTTSVETMKNWHRPRIQALVQAGVDLLALETIPCQEEAEMLCDLLREFPHIKAWIAFSCKDNQSIAHGESFQKVAKKCWETNPDQLVAVGVNCCAPSFVSNLVKGFNDDRPHDPIPLIVYPNSGEKYNPQIGWIDRDKCEAVEVFVQEWLELGVRYVGGCCRTYAADVSRIRNQVHCWRDRWRFQAKYPNAQNNNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GH25</accession>
    <name>A0A835GH25_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Xanthine dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HW555_006152</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BAW_Kor-Di-RS1</strain>
            <tissue evidence="19">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="16">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="16">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000089">
        <property type="protein sequence ID" value="KAF9416485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GH25"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000008">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="17">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="209"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="1205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1031"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF9416485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141255" checksum="28F189E1F89A0C9D" modified="2021-09-29" version="1">MDTIWFKVNGVRYTVKSGEVNSDLTLLDYLRNHLELRGTKYMCREAGCGSCMVTVKQSKGQPYAVNSCMLTVVSCHGLNITTIEGLGNRHTGYHPLQTTLAKYNGSQCGYCSPGWIMSMHSLQESNPNLTQLEIEQSLGSNICRCTGYRPIFDAFKSLAVDSVDKNLQDIEDLKICEKTGNKCDEQHCDDSDWCIVKEDDLLNTRMIQMKLKDGKYWYKVTCIKNIFDILDDKGEDSYMLVAGNTARGAYPIEEFPRVMIDINAVPELKGYKIDQNLIIYGGVTLTELLDIFKRIAAQEYFAYLTKFYDHLRKVAHIPVRNIGTIAGNLMIKHKHNFFASDIYLLLQTVGAQLTLVRRHSRTKTVTMEEFLKIDMKGVIILNVMLPPLSCEYQVATFKVMPRSTSYHSIVNAGFLYQLHNQNKVICSRIAFGGLSPSFTRASKTERFLTGKQLFTNDTLQSAVKVLNEEIVVEENPPEPSVEYRRKLALGLFYKGLLSLCPDNLLNARYKTGAIKIHDTRPVSKGVQYFETDPSTYPLNQPIQKVEALIQCAGEAHYTDDLPSLPNEVHAAFVVTTIGVGEIVSIDASKALSQPGVVAFYTAKDIPGHNSFTPTNGRNFPVDEEIFCEKQVKYFNQPLGVIVAETHALAEKAAKMVKVQYKNIRKPVLDVKEAIKDPNRVSFYASDDATDVGKDVQKVIKGGVTIYAQNHFCIENIPCVIRPTEEGIKVYTSSQYVDSIHVGMSKALNVDQSSIDIYVRRVGGSYGLKLTRNVQAAIACALVVLKLNRTCRFIQSLTSTTRSLGKKLPSTTNYEIAVNNSGVIQYINYNLYMDNGHTVNFKFNFLIMSSYNNCYDKSRWNLRCYNATTDVPKNDWLRAIGALDGIAHAELIMERISYELALDPIQVRLNNLDRQTSGAIEDMYDTLKSQAKYDDRRLVVDNYNKQNRWKKRGLRFSFTRWPLPALGYNNVLLSIYHGDGSVAIAHGGIEMGQGINTKVIQVCAYYFKIPLSKIKVKGYDTMSTPNSAETAGSIGSQNIALGVSRCCETILERLKPIRNKMGDATWEQIVEAAHTAGIDLQAQSFVNTSDATKYSYNVFGVALAEVEIDVLTGESELIRVDVMENVGKSISPEIDVGQVEGGFMMGVGYWTSERLVYDKNTGELLTNRTWNYAVPMNTDIPQDFRVYFKKNSYSYAAIHGAKAVGEPPMCMSVVVALAIREAISEARKESGIPTTQWFNIDGPSTVEVIGLSTETKVSDFKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHK1</accession>
    <name>A0A835GHK1_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_005223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000065">
        <property type="protein sequence ID" value="KAF9417809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF9">
        <property type="entry name" value="ECHINUS SPLICE FORM 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="27"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1275"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1546"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1298"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9417809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1622" mass="180219" checksum="47BD2358121E2C2C" modified="2021-09-29" version="1">MIKFRYKRKESSDGGKSGTAIQKQKIEGLRDRELLPPKDMLLTGSLAGVRNNTLPRSRPSSAARREPPETPLSQTTIALFRELFTQLQWSAERAPAADGLRRALGGGGARFQLGCMADASECFEHLLLRVHAHVAAGSGDRRDDDACRAPHCVPHRKFAMMLVEQSVCSACQATSEPLPFTQMVHYVSATALTAQAALGEHGDSFGLLLRKAGGMGDIRDCPNACGAKIQICRTLMNRPEVVSIGMVWDSERPSAEHVAAVYSALGTELRPTDAFHACVDRAWAARATHRLVGLVTYYGKHYSTFFFHSKLRLWIYFDDADVKEIGPEWSHVVEKCQRGRFQPLLLLYAAVDGTPCDTRHAPKDVVPFPAPEPRRAVTPAPERPATGFARRAVTPGPDNESDYVSRKAVENMLEVQANRRAQLNRSLSTGSGSDSQERPRARRDSGNWSGDRNSASSASSSTAESPYMYPRGRGAGSVPGSPTRKGELSSGGSCDAGYDSYSLSSTDSLPLQQGLRHNLQLAQIPEITTRGECEALCLEADRLLEKSRNAEDSADYETALVLCEAAASKARAAMDAPYNNRHMVTFARMKHNTCVMRARSLQRRMAGMTRVTEIPQAAPIRNTKGGLEASPMTIEIYATLPKKKGSSKKSPKCIDDDIDTVTRERPPRHKSRDDDKVREKRSRSEDRSRARKEVPVVKAAEKKEETPEEKKANKKQHKIRRKLLMGGLIRRKNRSMPDLTEGADGNNEAANKEKRVSSVDDTEVGRTTEDKTNLSGYLSEGHLEYSVASGTNPNLERSKLMRKSFHGSAGKMLTAAKVPPPPPLRTTSQLTGSKYTYSEHGKGTYPTEIEEDGGFSEQYGDEPHSLPFLHPYDDKSNSHYDRLDTSPAQNFHTVVTKAMIHQEQSPVKRETMQPIMPSHNTIQNLTHTFDNGVDVVDCAMPMPSRRSPTMFELPPYPSPMNSVNHSRQPSEEFPPPPPPIDLTPLHDELEKIQTVNEMSNDLEVAKGTLLASLQEKRNQILRNEQCAPQIGQVEKLNVHPSLLKELQAKQASFKLKRSGSLEGQLSSSVDAHNLYETSNNVRNIASRFENNAQNSSQDSDRTHIGFGMSGNRDVINCSDQSNAGLNRRASASSIDPKQIEEEQCDPKSANNTYGDRSKPKKKSVSFCDQVILVSTAEDQEDDSYIPNPILERVLKSAMNKPELTTMPLQSEKPSLQRQDSFDSQSSRSTISSLSQNSFVPNENAHAEYVRLQNNYPAYQMLPNRLQQQYNAQKNNSVYGTNSPVQTTQNQNGGNSNQIYQTLPNNTQQSTTSPIPYTQPPSVYPNHSNASPPNFSQTPANRLTPTHNPAYMSKHPVNLQRPATNAAHPASQLHPMNQAINNAYYHRVPQTSCPSTIPNNNYTTNRQYGHNMPNTNHSPYQSVPTNSPAYQSYHNPPTSYASSEYSSRYPQANSTNHYTQSPYQRVPPPHGDIPVENYNAYPQKMANNYYVDNQSGQQRAQETRHYANTQHQRSMYSQNPNVDSNVNSEQVGQYQYAQNGYNPYQHMPPPKQIQKKSVSFEPGTKGGTDSPIPPQMNGNPPYPAGDSQTQKSVCNLCRKKAINPPAMYCPDCDFYMSRFKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHS1</accession>
    <name>A0A835GHS1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_005814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000080">
        <property type="protein sequence ID" value="KAF9416986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHS1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9416986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="181" mass="20274" checksum="7F3A7EC4A3F085ED" modified="2021-09-29" version="1">MCLKQTTNAVNWLEPDEVKRCCCCVPLRHGIILFGLINIIFSMLAVTSLVITTELKKSKLLDGSSLEVVTSTILFSIFGMSVILNIMLLFAGCQKDVLMLRLYLYYGVVTTLAALVPTFILASRMMTYDVCVALFAICMQWYVIILVRSEIVKLEQASLRAENSSLVHEVTIDVPDRETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GHY2</accession>
    <name>A0A835GHY2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CTP synthase</fullName>
            <ecNumber evidence="10">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_004988</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="10"/>
    <dbReference type="EMBL" id="JACKWZ010000061">
        <property type="protein sequence ID" value="KAF9418080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GHY2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="315"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9418080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="581" mass="65152" checksum="10138A12AE136432" modified="2021-09-29" version="1">MPDMKYILVTGGVISGVGKGVIASSFGTILKSCGIDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGGEVDLDLGNYERFLDITLHRDNNITTGKIYQQVIERERRGDYLGKTVQVIPHITDAIQEWVQRVAHIPVTPDNAPPRVCIVELGGTIGDIEGMSFVEAFRQFQFRVKRENFCCAHVSLIPMPKSTGEPKTKPTQSSVRELRGLGLSPDLILCRSEKPINQGVKEKISNFCHVGPEQVICIHDLSSVYHVPLLMEAQGVVQYLNERLQLNMSMPRPGKFMRKWHNLAKRVDNLRKEVNIALVGKYTKLEDSYASVTKALQHACIASGSKLNLTYIEAVNLERQTKIDDPVSYHKAWQNLCKSDGVIVPGGFGQRGMEGKIEACQWCRETQKPMLGICLGLQASVIEFARNVLGLKGANTTEVDPKCEDKLVIDMPEHHPGNLGGTMRLGKRKTYLEPSVITQLYKKDVIEERHRHRYEVNPEYIDRLEAAGLRFVGKDETKTRMEVAVVDNHPYYVTVQFHPEYLSRPLSPSPPFLGLILASLGKLKNYLSKGCRLSPRNQSDVSSDEMIYQCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI67</accession>
    <name>A0A835GI67_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-galactosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HW555_006673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BAW_Kor-Di-RS1</strain>
            <tissue evidence="9">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI67"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="8">
        <location>
            <begin position="519"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF9415772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="884" mass="99206" checksum="D25E0318D32B50BA" modified="2021-09-29" version="1">MADAVTDKNRSYRKMYEFRCAFCLLFLIFSFNKVDLLENGLARTPPMGWMSWGYYRCGVKCEEGEHKCLNEQLILSVADSFYNEGYQEAGFEYIIIDDCWSEKKRDRNGRLVANKKRFPHGMKYLADYIHARGLKFGMYTNVANTTCMRYPGSLSHMELDAKTFAEWGVDYLKVDGCYVSEEILNTAYIQLGRYLNKTGRPMVYSCSWPYYIQYIHQQMPDYEEVARYCNMWRNYHDVQTSWDSIADIVRHYRGEYALLAPYHGPGHWNDPDMLIFGTGVLTHSQSRIQLTVFVMMSAPLLLSCDMKKITPYEKSLLQNLDLMAIAQDPLGIMAEPYGVTGCTLWIKPHLPRKGDQFPSYSLAIMNLDADSSDVSFRLSTYNLNATDGYTILDVFSGEFIRNVTYNDKIEVTVPGLAMTVEKCEPLRIVDHINTYGKCLVDKGNKEVEMRLSLVLLAVCIARGVHSLGTLDDIIGAPGKLVDGARGILGGILGGNIGNRNVCNRNVYKDYSKAVTSFHHKLYTSVAARTDGHFVFSPYTVWLSLSALAEGADPSVQSQIFASLYLPEENCIRKKFYEIAVNAEQSGRDVLFNRRRILLLDEDLKVNPPWGKTVKALGLLKAGFASIKNNPRQTLQRVRKFIGTQANIPLRGNSVILDALEYQGLWTAAFSEADIKRQPFYNEQGLVIGEVDMMHIRKRVRLAQAPFLGAKVVELPVGVDGRYTMLIAVGTGNNILKNAISMFMGSILEIFSLLQMSLVPLDVAVPRFSISSEFDIRAALEDFGVKSFWRDPLATKYVSDPSALPGSFIQRVSVSVDSWGVEPAPQRRQGLVSGLLGVASNTATGVASFAGQEFTADRPFLFALFDTATRTCLYAGAYSKPNPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GI78</accession>
    <name>A0A835GI78_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_006688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000102">
        <property type="protein sequence ID" value="KAF9415787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GI78"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050078">
        <property type="entry name" value="Ribosomal_L11_MeTrfase_PrmA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9415787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="129" mass="15163" checksum="AECC7EFDEEF96668" modified="2021-09-29" version="1">MYDIHFGQRRSIQESFHFRCWLWMWSGKCRRCKSRSEKNNLIGDCCEEFDTILIGDMFYNEEFASLLFEWLNRISTEGGKTVLIGDPGRHGLTPTRRQQMSLAARYVLPAHVCMENHGFTHADVWSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GIX0</accession>
    <name>A0A835GIX0_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000051">
        <property type="protein sequence ID" value="KAF9418724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GIX0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="80" mass="8555" checksum="F15BCB0CB3517A03" modified="2021-09-29" version="1">MEVSHKIIGGYDCVKGAISGKKGRGVTINRHRKRIRAPGCIPGTDLCNLHPPARQSTPALMNVLCDLISFGSKHGLGFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ51</accession>
    <name>A0A835GJ51_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein msta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_003993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000042">
        <property type="protein sequence ID" value="KAF9419493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ51"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF2">
        <property type="entry name" value="AT24727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9419493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="135511" checksum="684D08AB32412E14" modified="2021-09-29" version="1">MALFIHISVCYAIKAMAHTSEELGRYLVASRDLTPGDLVLTERPLVFGPKGMLDPEEVMPCVGCYKPVLTEAGERCAKCGWPVCSGNCPGLKDPRHHAAECEILSLRSECALNDMADYYRHDALLPLRCVLLQKTDPEGWKKLLEMQSHMECRTPGTEAYDEANEFIFEYLMNNFVSKLDEKQKKTFEITAELLHRICGIIDTNALEIRLPQGSELNALYAETYKMEHSCVPNTKHTFNLSAKDRKDLYKITIKAVVPIVKDHHISTMYSHALWGTQARRQHLKDTKYFACKCPRCSDPTELGTYLSAMRCLGDGNNSCDGIHLPDDPLDDETDWSCNKCPAKVSNSQVNMVISQMGEDVENVLMMGGSVTVLENLLFRLSNFLHPNHYHLYTIKHSLVQLYGRQPGYQTKEILEKKIKMCRELIAVTKALDPGNARLSLYNSVLQHELHSALVMKFKNGLKDEEVKPLLIEAKLAVEDALYSLKDDIEEVSGKKLQCVIEDSKHQFEKLCKQKNLQHIQRFTLYSLKNMEDKNGSGVLAYHLVQSLDDDVGRHLVASRDLSPGDVVLTERPLVFGPKAMLDPEVAMPCVGCYKPVFTESGERCSKCGWPVCSGNCPGLKDSRHHGAECEILSLRPECVLKNMADYYRCALLQKTDPEGWKQLLDLQSHMECRTPGSDIYEEANEFIVEYLINNFINKMDEKLRKTYEITSELLHRICGIIDTNALEIRLPQGTELSALYAITCKMEHSCMPNTKHTSFAFNPKDKNDLYEITIKAVVPIMKDNHIATMYSHALWGTQARRQHLKDSKYFACKCPRCSDPTELGTYLSAMKCLGNENKPCDGIHLPEDPLDDETDWVGNKCPVRVSSSQVNMIMSQMGEDVEAVLMMDGSVTILENLLCRLAMFLHPNHYYMYSLKHSLVQLYGREQGYTSMDILDKKIKMCRELISITKALDPGNARLSLYNTVLQHELHSALLMKCKNIVVAKAEEIKTLLTEAKSAIEDALKSVKDDLEEVSGKRLQSVLDEIVSLIPRLENSSNALLDSLPLIPSLFSKSSSSEKAAEIRVPIQPTSSFISVDTLYYPVCVPRYSGVYSRHPRSSTSTASRNYSYHHHVTSVTIIPDHEGATAVSLMHVTCVIPQYTHPARITTPNFMSSTHLGGYDLDLAALRSVPAIALIIGNHCYFCLLLENNNDSSSASISTCLSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJ93</accession>
    <name>A0A835GJ93_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eclosion hormone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">EH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ecdysis activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HW555_006094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BAW_Kor-Di-RS1</strain>
            <tissue evidence="4">Whole-body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neuropeptide that triggers the performance of ecdysis behaviors at the end of a molt. It triggers adult behavior patterns: larval, pupal and adult ecdysis, and plasticization during the molt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the insect eclosion hormone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000087">
        <property type="protein sequence ID" value="KAF9416585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJ93"/>
    <dbReference type="OrthoDB" id="6432957at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008255">
        <property type="term" value="F:ecdysis-triggering hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018990">
        <property type="term" value="P:ecdysis, chitin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006825">
        <property type="entry name" value="Eclosion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04736">
        <property type="entry name" value="Eclosion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001859">
        <property type="entry name" value="Eclosion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0372">Hormone</keyword>
    <keyword evidence="1" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032860771" description="Eclosion hormone" evidence="3">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001859-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF9416585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="88" mass="9456" checksum="A9EC03A35E5F5885" modified="2021-09-29" version="1">MAGKITAAFFVFVTIAFLANIGFVVGNPAIATGYDPLEVCIENCAQCKKMLGAWFEGPLCAESCITFKGKLIPECENFASISPFLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJE8</accession>
    <name>A0A835GJE8_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HW555_003829</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BAW_Kor-Di-RS1</strain>
            <tissue evidence="17">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 19">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JACKWZ010000040">
        <property type="protein sequence ID" value="KAF9419710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF495">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032269159" description="protein-tyrosine-phosphatase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="215"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="322"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="421"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="843"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="1174"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="1363"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF9419710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="1438" mass="163102" checksum="730161CFFDAAC987" modified="2021-09-29" version="1">MTMGSTVGKYPAALVLYFLCMGLWYPILAQDEVKIIDLSPWKANLHNTSEVTCTVAPENAEISWMFQAKPLVPNNRTNATTSKKDSTEGERYILSILSIKDTNSEDAGNYTCVAKVGSAEDSKVANLDLSFPARLVNTTSTYNPGEVRWWTRTKDNVKLLSETNNTRRIGGDLIKSTYVLHIYGIEDNGTYACELDDLVSSTIVSGKIDVLLTAKPQIIIENVIPINTTHVYINWTVHAFNSPIKEYRLMYLNEKNMAAGFRHYTVPPKIDAANTSFLLGGLEKGTTYTFKMQVVTEYDESNRDSPESLYHNVTMLFEDPVFVPNISINGFSATSVTIGWAPPPDDIADLIHYYILEAQKKDNGTINLRACHERNGKNLPYMFDNLEPHSTYVFKVQACSDYSNSCGNWSEKMEAATLDGVPGVPSNVVAKCSVDFLNLTWSAPLKPNAEIKGYTMEITGNMTYKDRFGVERVATVNDLPPNTRFMIRLSAVTRTRRRGEENVTFCHTLPAPPDSPPRPRWRKILENGTYMFKMYLPRMSERNGPICCYRVYMVRLPTGNIDWKRLPSPRDIDVLEYKDSQTKLGAYVADVFSNDKFTRDNIELVLGDDKVIFDKQTDPTLNQDRCRRCLKRPKRVHHEPTPAPITTTTLDDFEADLMDFAEGTDDPIERDNSDRISRRSPDNIDFSNNPTMLNKQEDDSEIRVRDGPLDPTANYTLFVELISSSDPDEALFSEYTSLLMPTASPPVPVPSTALEIALQITCAVAAVILLLMIVFCIMQTRRTRKMPAHVQIDNPFSYALRYWDSIRGRQPLVSTVPPDIPPIPKDELAAAYAQRQVDSDYGFQKEFELLQMLPECFPDRTTHASEARENQPKNRYPDIKAYDQTRVKLSQIDGITGSDYINANYVMGYQERKQFICAQGPTDTTVNDFWRMIWEHGLELIVMLTNLEEYSKVKCSKYWPEERSSRAFGGITVHHIGEKRYSDYIVRELKITKQPLTADGQPIVENNGIAKRNGDIKEASESSAPTSPREVKESGECRIVRQYHFLMWKDFAAPEHPHSILKFIKRVNEAWTSMVGRPVVVHCSAGVGRTGTLVALDCLLEQLRATGQVSVFNTVAELRRQRNFLVQSLKQYVFVYRALVEYAHYGDTEIPASRLKPAVDRLRNTPDHADKCLMEVEFEKMLNSPVAEPLKSMGAGAGEELRARNRSPDCLPYDRNRVILTPIPGRDFSTYINASFIEAYDNSEGFIITQDPLPNTIMDFWRMVSEHNVTTIVMLSELGEGKCPRYWDDGTVQYEHISVQYEESESCPYYTRRQFRVTNDKSGEVVLVRHLQYQGWPTARGHVPEVTRGLADLADAAAPALAPTMLVHCQFGTERSPLFVALCTLIRALRVERRVDVSATARAVRTQRARTIDTFLQYEFLYRAILNYAELHNLLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GJN2</accession>
    <name>A0A835GJN2_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HW555_003728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BAW_Kor-Di-RS1</strain>
            <tissue evidence="11">Whole-body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GJN2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="373"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF9419895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="693" mass="74184" checksum="EF32B10B02013077" modified="2021-09-29" version="1">MPITKRQASSTCKMAADNLTALLKKPKDLQLVQTPIPEIADDEVLLRMDCVGICGSDVHYWQTGACGHFVLKEPMIMGHEASGVVAKLGAKVKNLKVGDRVAIEPGVPCRYCEFCKTGRYHLCPDMVFCATPPVHGNLVRYYKHAADFCYKLPDHVTMEEGALLEPLSVGIHACRRAGLTGGHNVLVLGAGPIGLVTMLSAKAMGASKVLMTDVLQSRLDFAKKLGADATILSTKDTSEEDMVKKIHELLGGQPDISFDASGAQATVRMAMLATKSGGVAVLVGMGAPEQTVPLAGALAREVDIRGIFRYVNEYPIALNMVASGKINVKPLVTHHFTMEETLQAYEVARQGAGIKSRDSNSTMADNIAAVLHGPYDIRIENIPVPKINDDEVLVKMDCVGICGSDVKLYTTGACGMETISEPVVIGHEGAGVVVEVGSKVSSLVVGDRVAIEPTQPCRACEYCKVGRYNLCVAPRYCSTTGAPGNLCRYYKHVADFCHKMPDNLSMEEGAAVQPLAIAMHACNRAEIRLGQRVLILGGGPIGILCAMTARAMGASTILITDVVQSRLDTARELGADYTLLVKRDYSDQEVVDGIVAQLGCQPDVTIDACGYASAQRVAMLVNYYAIDTKTLLGSPAARLSNNLVRLRVTNLMVTKTGGVLLVVGIADNKVEVPLSQALLREVDVRGSFRIVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GK10</accession>
    <name>A0A835GK10_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 18">Mevalonate kinase</fullName>
            <shortName evidence="18">MK</shortName>
            <ecNumber evidence="3 18">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HW555_005741</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BAW_Kor-Di-RS1</strain>
            <tissue evidence="21">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 18"/>
    <dbReference type="EMBL" id="JACKWZ010000077">
        <property type="protein sequence ID" value="KAF9417122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GK10"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="19">
        <location>
            <begin position="148"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="20">
        <location>
            <begin position="330"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF9417122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="412" mass="44718" checksum="E9E6B057CDB0969D" modified="2021-09-29" version="1">MLNGIDNLYTVSVSAPGKVILHGEHSVVYGKTAVAVSLGLRSSIVIKEVNYHVEPTIRIHLPCVGLEETLPLEPTVKSLFHPKLAPGITGKFSWRLPDKIDHDSHLRRVDEFLHLIKPNFDALQNNQKNSLRSFLYVFSGIFGSTNLPVKSMEISLGSELTIGAGTGSSASFAVCLAGALIQLLKLKSSTGFDAFYDQTSEDFSMNEREIISEWAYNCERIMHGSPSGIDNATCTFGSLVSFKKGSKPRHLDIKMDLRVLLVDSRVSRETRALVVKVAALRQRNTAAVDHILDACDHVAHTATQVLEKLSSGKCEIDYDAEYQHLAELWDMNHCLLSALGVSHPALEAIRGAARAKGLACKLTGAGGGGYAMVLIPPSTPRSVVDSLCGQLLENGFRVKETRLGGPGVSIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GKX6</accession>
    <name>A0A835GKX6_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GKX6"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21253">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21253:SF0">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032884157" evidence="1">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="328" mass="37798" checksum="CEE236E918D3E550" modified="2021-09-29" version="1">MNVQYIVIVFLVSELFSVNARKGCDNVRAPLNGLRKRRHLTFPEGTAMVLTMSVLKAIMVHAPSGWNVAVEIDVIYPLLSPAVTNALFRKKLHHRQKREFWEKMQNALDSYNLNGRSCIYRSICEARTHLAPPGKSLVHDILRAIFFAPVHEEGFKDEVNETYNELLEPNVCERIHDCPISLLEVTTSVVKTFMTHVPSGWYVVVEAELVYMLPDHTVISAHKRRKLHHRQKKEIWETLEGVLEQRNMNGRACILRTICEAKMRLAPKGKSLVHDILRAMFTAPLEEREFVEEMGLTYNELLEPDFCMKANDCPLSILSFILDLNRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GL84</accession>
    <name>A0A835GL84_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_004763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GL84"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032944951" evidence="2">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9418475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="493" mass="51362" checksum="A084018D98426836" modified="2021-09-29" version="1">MNRKCILTIFTIILIVCAEARKTSGRSRGSGSGRGTSRRTNYNPQPAPTSFSQTQAQKPTLFGWQERPGQSSWQTKSSSGQSHSYPSSGTGSHTYPSSGSGSQKYPSGSGGSGSHTYPSGTGLSGDNKPKQPSSPNQQAGHSYPASPGLSGSANGGYPQQTGSKYPQQGTGQSGYPQSAHSYPQQHGVAGSAGAPPPYTPHQNNYGNQYHPQGPPPPYSNYGGSNYGGVGGYGYNPGLGPQAPGYFGNYGKPSGGMSRGGSALAGVGIAGAGIGTVLTGLALWNLARSTGHHHHTVIYDNRGQPVAVAPVNDTSAPTDSILADLVNCSLTISNDDKTEVLAIPCSIATSFTPDANVKDSDVNKDPNDNTKCTIAVLTKAGKEYMTTIPCSILLNTAAENNVTEPPLVIDQPINNNNFTGEPDMIQNGTMIENISKGEPTALRLSGEDVNGDDKTLAQLNCTVQPEEIRDPINPCFSINHNLTVIPLPTTEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2022-12-14" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GLV5</accession>
    <name>A0A835GLV5_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HW555_004743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BAW_Kor-Di-RS1</strain>
            <tissue evidence="1">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000055">
        <property type="protein sequence ID" value="KAF9418455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GLV5"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF9418455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="120" mass="13166" checksum="1D839E34952660AC" modified="2021-09-29" version="1">MINYLIVATITEIIVSFQPDDRSNRVALGLVPLSPLTRGSLCRITLLHPRKEVGWSRRRRRSWTSKCALLRTPGRPQQPGNCADTVVNINVPSSSIGNSMGSSFSSSATGKYSKDIISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMG0</accession>
    <name>A0A835GMG0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Neutral ceramidase</fullName>
            <ecNumber evidence="2 7">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HW555_004779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BAW_Kor-Di-RS1</strain>
            <tissue evidence="12">Whole-body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2 7"/>
    <dbReference type="EMBL" id="JACKWZ010000056">
        <property type="protein sequence ID" value="KAF9418349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMG0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="10">
        <location>
            <begin position="61"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="11">
        <location>
            <begin position="578"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF9418349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="725" mass="80229" checksum="D3FD98490ECA7E50" modified="2021-09-29" version="1">MACTLVGKVVSAVVVLGVIAGMAAVIVLTVNENNDSNKSSNSNEAETSRPITTERESDLPYRVGVGIADMTGPCVEITFMGYAEVGQRGRGIHTRQFARSFIFAKGSSRVVLVTAEVQAVGIAVRREVVKNLQERYGDMYTLNNVILTGTHTHSTPGGHMVDFILDISILGFSRETFSAYVDGITRSIVRAHENMVPARLFFGQTTVTGAQMNRSPFSYDANPKEERARYEHVGNQTDITLTQVKIVREDGRLHGVMNWYAVHTTSMNMTNQLISSDNLGYAALRMEKELNPWRKPGKPEIVAGFFSSNLGDVSPNTQGARCEFSGKECDNQFLICEQMERCFAQGPGKDMMESTKIIGTTVFEGALDLLNTPDEELEELTGDISVRHQFMRMAEQTVPKYNTIEQTFDNENMVKGCYPALGYSFASGTIDGANTMNITQGTLEPMPILGFIASLIGAATEEDKNCHFPKPILLATGRANFPLPWHPHIVSASVVWLGGLAILGVPGEPTTMAGRRMRAAVGKLMESKGIEPKVVVSGLTNEYIHYVSTFEEYQVQRYEAASTLYGPHTLDVFINKFVELTDAIIEDTEVEEGPSPPDHRNRILSLITPVVLDSTPLNQRFGDCVIQPPARVRRGDVVSATFVGANPRNDLKQEESHAVVERLELAEFRWERMSLLRGTSQVTFEWRVPEDAILTRYRIVYHGAARAIRGSLTPFRGVSDEFELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMH4</accession>
    <name>A0A835GMH4_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Density-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000026">
        <property type="protein sequence ID" value="KAF9421133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMH4"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000004">
        <property type="entry name" value="density-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9421133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="176" mass="20065" checksum="4BA276AFB6F2D5D3" modified="2021-09-29" version="1">MGDRDLSMGPRERTYPIKVQYCGNCSMPIEYCEYYPEYDKCKQWLEKHLPTEFEKVKIDEEENAGGEEEKKRQKRGGKGMLKSKKKEDVPKLVQVSRAPRGKKKSVTVVSGLSTFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDIIPEKWPEIDEDSIEDLGDQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMU1</accession>
    <name>A0A835GMU1_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_003697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000038">
        <property type="protein sequence ID" value="KAF9419864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMU1"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF6">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032385425" evidence="1">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9419864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="175" mass="20666" checksum="519B54C8FEB8A6F0" modified="2021-09-29" version="1">MNKFIPVLLLCYICVVAFIVIDVSEANDTKVLHRNRRYLSFLNMTRFYLKFNFKANIVPWNQLFAQAIGFRMNWNGPPSNFRPFHRIYRRDIYDYVETLLDKNGLDGLHCVRRAICEMQTIAEPNMIYHKVLKMVFRKMSPTTERWHNVTTEDCTTSITACPLSLLQVSPYTDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GMW0</accession>
    <name>A0A835GMW0_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Intraflagellar transport protein 57-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HW555_002142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BAW_Kor-Di-RS1</strain>
            <tissue evidence="5">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT57 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GMW0"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019530">
        <property type="entry name" value="Intra-flagellar_transport_57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011">
        <property type="entry name" value="IFT57/HIPPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10498">
        <property type="entry name" value="IFT57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF9422121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40382" checksum="58AA243ADD3E8833" modified="2021-09-29" version="1">MKPMSRYYFITGTNPGEQFYVFASTAAWLIRKTGKEFEQPNEEDDPNSIIATILDILREKDIAVDFSSHKLKQGYGEQVCYILNVLADEALKSEEFEWQKPIVDIPEPEEAADDVDQVEDETEILLDKVEEEMAIYSGESEEEFNVEEKESSLVKKVHDWEAWKLELERVAPALRLKISADGRDWRARHSQMRTYRDELFERYKTTGSQLNKLHTNISSVMDKISARENILNEQFEPLVREYGALLDELNKVTNEYKDVSVGVTERQEMLNELTSKVENIKQRTESKGSSMNDNSPLVTAKKAVANLKKDIQDMDFQIIILIWLLTTKENPNSNNLFTNAESKMVGIESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GN96</accession>
    <name>A0A835GN96_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HW555_002412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BAW_Kor-Di-RS1</strain>
            <tissue evidence="3">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000022">
        <property type="protein sequence ID" value="KAF9421731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GN96"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF9421731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="717" mass="81159" checksum="D117BF1C97F12E97" modified="2021-09-29" version="1">MEMEVPNPENGSKQDLNDSGCVQDTSVIENGYVSSLHLLDLSDDALLCILKFCDPMALKAIGHTCPRLGALVCDRTLWQRVDARTTPMGKKRIRWMLNNCLSHSTTELKIAGYANKFSSSLHLLDLSDDALLCILKFCDPMALKAIGQCLGIQDLQWPVPAESTGIDVEHFLLRMWYPHLPRFVVPPRWPNKAEVERRAQRQAKKRKAEPSCSKEDPEEERPYDDGFPKDLDDGLSKECKGPQFSLSAAIMKELMETCENLTTLYLEYCNVDYRTTNIRLFPKKLKKLSMRGSRCYNLPLNVSYLAKVHEMLPDLEYLDVSECDWFEPASLMTISKLPKLTEVYMRDCKRLTECVFDSRGSPLADSEISSLGWLPELQELYCSPPDVLNTLSEHTHSWKDTKTEFPELEDWELDEPEYYRAKSPSAAEADEDDSCDATERPSDLLRENPMWSNERRVIVIQPNTARIINGQYANPRERQDEPQPGPGMVQIPIPAEPRQQPQPGPAQPGPSPQPGPSPQPEAGPSKRRAQPDEPNEGKRPRMQLDNEENHVNDNEEVSPPVRLRYVNLYGQSPPENRAAPPNAHDRPLSRDLIFNADSPFNISNHVGYHLVSDTAILRFGRAENENVNYVHIGRSRGNPDENQTFDHRPDRANLRILSATGYRHITNRSLEHLATAAPHLLHIDFTDTGVTASGVEIFKAIRPNCEVIFGPLESQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GNP2</accession>
    <name>A0A835GNP2_SPOEX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HW555_002086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BAW_Kor-Di-RS1</strain>
            <tissue evidence="2">Whole-body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000019">
        <property type="protein sequence ID" value="KAF9422065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GNP2"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF9422065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="651" mass="76152" checksum="988C9C3A40D03061" modified="2021-09-29" version="1">MRPKKKPKTKEEIKEQKRIAERLRYQRLKNDPVKREQLKEKERRNYQRKKEKGTRKLVKDMCRREHKAVTKEWRKHRAKNHEKKSFERNNKQFCTTKYSGIRGFSFSSIPMTTPRNDASNARKRHARKKRDKIIKYKDKKIEKRLERLEKAKTKENVDTPNTKLIKMCDSPVTRSEVVKKALFGELLNAQLKENYANLKTCQEKQIFGKVRYYDRWREQVPKLRTRKEKISSDCIKTVRTFYENDDNSRLGAGKRECLTRKGVKKQKRYLSDSIANLYKKFQAEHFKISYTTFCRLRPFWVITPNVSERDKCLSIKHANIDLKLHTALLEKTCCNRYDELCLSRTCQRCIDKNPNYSEFDDSKPIEFKKWISEKQTYKDPKTKNVRAVTKYLKKTFTRWARNSIQKQNDVLHPGINTSTRESGHGKGAPDRIGATCKKTADAVVATGGDIDSLESFVEAIQQRCSAITLLTIDDKAIQELTDDLQNETVNLKSLSCTCEDECQHFNLGVLEYKNKTKLNVDDIYTDSENENIDNLQDPTMETDDDAALAGPSSINQQNYTIGDYVLVKFLVRNTEYCYAAVINKIDMEEGELTVTFLKICDDKGHTFRVDENDVSDVSFDQVLKKLPNPDIALKGKRIFYYFNIPVPVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GP49</accession>
    <name>A0A835GP49_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HW555_001485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BAW_Kor-Di-RS1</strain>
            <tissue evidence="13">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000012">
        <property type="protein sequence ID" value="KAF9422942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A835GP49"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF9422942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000648187"/>
        </source>
    </evidence>
    <sequence length="415" mass="47131" checksum="08B0062FC2B337C6" modified="2021-09-29" version="1">MEEIGIILPEKDDQVTDAKGLPFAGHQTFDELESEDLYTKYKKLQRMLEFLEVQEEYIKDEQRNLKKEYLHAQEEVKRIQSVPLVIGQFLEAVDQNTGIVGSTTGSNYYVRILSTIDRELLKPSASVALHKHSNALVDVLPPEADSSISMLQADEKPDVQYSDIGGMDTQKQEIREAVELPLTHVELYRQIGIEPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITAKMNLSEEVDLEEFVARPDRVSGADINAICQEAGMHAVRENRYIVLPKDFEKGYKNNIKKDESEYEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A835GPA3</accession>
    <name>A0A835GPA3_SPOEX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lactase-phlorizin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HW555_003299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Spodoptera exigua</name>
        <name type="common">Beet armyworm</name>
        <name type="synonym">Noctua fulgens</name>
        <dbReference type="NCBI Taxonomy" id="7107"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Lepidoptera</taxon>
            <taxon>Glossata</taxon>
            <taxon>Ditrysia</taxon>
            <taxon>Noctuoidea</taxon>
            <taxon>Noctuidae</taxon>
            <taxon>Amphipyrinae</taxon>
            <taxon>Spodoptera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Spodoptera exigua strain:BAW_Kor-Di-RS1 Genome sequencing and assembly.</title>
            <authorList>
                <person name="Kim J."/>
                <person name="Nam H.Y."/>
                <person name="Kwon M."/>
                <person name="Choi J.H."/>
                <person name="Cho S.R."/>
                <person name="Kim G.-H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BAW_Kor-Di-RS1</strain>
            <tissue evidence="6">Whole-body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACKWZ010000031">
        <property type="protein sequence ID" value="KAF9420549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000648187">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="3"/>
    </dbRe
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